Search

Your search keyword '"S Lv"' showing total 74 results
Start Over Author "S Lv" Database OpenAIRE
74 results on '"S Lv"'

2. Multiyear in-situ L-band microwave radiometry of land surface processes on the Tibetan Plateau

Author

Donghai Zheng, Hui Qian, R. van der Velde, S. Lv, Hong Zhao, Zhongbo Su, Xiaoyu Wang, Yijian Zeng, Yann Kerr, Jun Wen, Susanne Mecklenburg, Simon Yueh, Matthias Drusch, Mike Schwank, Andreas Colliander, Zuoliang Wang, Faculty of Geo-Information Science and Earth Observation, UT-I-ITC-WCC, and Department of Water Resources

Subjects
Cryospheric science, Statistics and Probability, Data Descriptor, L band, 010504 meteorology & atmospheric sciences, Soil texture, 0211 other engineering and technologies, 02 engineering and technology, Library and Information Sciences, Monsoon, Atmospheric sciences, 01 natural sciences, Education, Atmospheric radiative transfer codes, lcsh:Science, Water content, 021101 geological & geomatics engineering, 0105 earth and related environmental sciences, Microwave radiometer, Computer Science Applications, Brightness temperature, ITC-ISI-JOURNAL-ARTICLE, Environmental science, lcsh:Q, Hydrology, Statistics, Probability and Uncertainty, ITC-GOLD, Microwave, Information Systems
Abstract

We report a unique multiyear L-band microwave radiometry dataset collected at the Maqu site on the eastern Tibetan Plateau and demonstrate its utilities in advancing our understandings of microwave observations of land surface processes. The presented dataset contains measurements of L-band brightness temperature by an ELBARA-III microwave radiometer in horizontal and vertical polarization, profile soil moisture and soil temperature, turbulent heat fluxes, and meteorological data from the beginning of 2016 till August 2019, while the experiment is still continuing. Auxiliary vegetation and soil texture information collected in dedicated campaigns are also reported. This dataset can be used to validate the Soil Moisture and Ocean Salinity (SMOS) and Soil Moisture Active Passive (SMAP) satellite based observations and retrievals, verify radiative transfer model assumptions and validate land surface model and reanalysis outputs, retrieve soil properties, as well as to quantify land-atmosphere exchanges of energy, water and carbon and help to reduce discrepancies and uncertainties in current Earth System Models (ESM) parameterizations. Measurement cases in winter, pre-monsoon, monsoon and post-monsoon periods are presented., Measurement(s) microwave radiation • soil moisture • atmospheric wind • Solar Radiation • rain • soil • CO2/H2O flux • thermal radiation • temperature of soil Technology Type(s) Radiometry (Microwave) • Sensor Device • pyranometer • Gauge or Meter Device • particle size analyzer • pyrgeometer Sample Characteristic - Environment land Sample Characteristic - Location Tibetan Plateau Machine-accessible metadata file describing the reported data: 10.6084/m9.figshare.12818261

Published
2020
Full Text
View/download PDF

3. THE OVERSEAS GEOMETRIC ACCURACY VALIDATION OF ZY-3 SATELLITES IMAGES

Author

Q. Yue, V. Chanthabouathong, X. Tang, Wolfgang Kainz, S. Lv, Y. Xue, and X. Gao

Subjects
lcsh:Applied optics. Photonics, Earth observation, Geospatial analysis, 010504 meteorology & atmospheric sciences, Computer science, lcsh:T, 0211 other engineering and technologies, Elevation, Orthophoto, lcsh:TA1501-1820, 02 engineering and technology, Shuttle Radar Topography Mission, computer.software_genre, 01 natural sciences, lcsh:Technology, Global Earth Observation System of Systems, Stereo imaging, lcsh:TA1-2040, Satellite, lcsh:Engineering (General). Civil engineering (General), computer, 021101 geological & geomatics engineering, 0105 earth and related environmental sciences, Remote sensing
Abstract

With China’s first stereo imaging satellite ZY-3’s successful launch and two satellites networking operation, space remote sensing becomes an important means of data acquisition for survey and mapping, and geographic information updating in China.The updating period of 4D products in China is shortened by one third, the geographic information updating capability was improved more than 2 times.After more than eight years of stable and continued earth observation, ZY-3 statellites data coverage has gradually achieved more than half of the earth land which enables the overseas service for global geospatial application. Focusing on the Chinese domestic mapping applications and services, the data of ZY-3 and other domestic land observation satellites can be real-time pushed and distributed across China through the satellite cloud service platform, and worldwide for facilitating the "Belt and Road" initiative, which is promoted through the GEOSS as well for global application.This paper presents the overseas geometric accuracy evaluation and validation of ZY-3 satellites images, which was carried out systematically for the first time abroad and complements with China’s mapping evaluation practices to provide a comprehensive technical guidelines for global mapping application. The direct location accuracy of ZY-3 satellites sensor corrected image products were further evaluated and verified cooperating with the University of Vienna, Austria. The location deviations in mountain area and in flat area were analyzed and compared to check the deviation pattern and validate their consistency with the results in China.Utilizing China’s ZY-3 satellites images ranging from 2012–2018, the DSM was generated automatically based on a semiglobal optimization method (Yue et al. 2016) using self-developed software SDP without ground control points but using SRTM data as elevation reference to improve the geometric accuracy. The result shows the elevation accuracy of DSM is 3.19 m (RMSE), satisfying the local requirement for 10m interval contour mapping.The planar accuracy of DOM generated without ground control points utilizing ZY-3 satellites images within 2012–2015 is 2.46 m (RMSE). With 128 orthorectified aerial photo slots provided by NGD of Laos as reference, the planar accuracy of the DOM generated utilizing ZY-3 satellites images from 2016–2018 is 1.65 m (RMSE), which can satisfy the local 1:25000 planar accuracy requirement and overlay with the local 1:2000 transportation data exactly. The overseas geometric accuracy evaluation and validation of ZY-3 satellites images provides a systematic and practical guidance for future global applications by complementing with china’s experience, which would be beneficial to overseas users in acknowledging the usage of ZY-3 satellites data and help to promote it’s global applications.

Published
2020

4. IκB kinase α: an independent prognostic factor that promotes the migration and invasion of oral squamous cell carcinoma

Author

J. Xu, Y. Zeng, Y. Fan, K. Wang, S. Lv, J. Zheng, and F. Wang

Subjects
0301 basic medicine, IκB kinase, Matrix metalloproteinase, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Cell Movement, medicine, Humans, Neoplasm Invasiveness, Lymph node, Tissue microarray, business.industry, Cell migration, Prognosis, medicine.disease, I-kappa B Kinase, stomatognathic diseases, 030104 developmental biology, medicine.anatomical_structure, Otorhinolaryngology, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Cancer research, Immunohistochemistry, Mouth Neoplasms, Surgery, Oral Surgery, business, Immunostaining
Abstract

IκB kinase α (IKKα) is associated with tumourigenesis, metastasis, and poor prognosis. However, its expression and function in oral squamous cell carcinoma (SCC) remain unknown. The aim of this study was to elucidate the clinicopathological associations and functions of IKKα in oral squamous cell carcinoma (SCC). We made an immunohistochemical analysis of IKKα in 94 tissue microarrays of specimens of oral SCC. We also examined IKKα expression in the patients' samples by quantitative real-time polymerase chain reaction (qRT-PCR), as well as the migration, invasion, and matrix metalloproteinase (MMP) activity of the cells under IKKα knockdown treatment. In oral SCC, immunostaining for IKKα was found in 60 of the 94 patients, and it correlated with lymph node status and poor prognosis. Univariate and multivariate analysis using Cox's proportional hazards model identified that IKKα expression was an independent predictor of distant- disease-free survival (p

Published
2020
Full Text
View/download PDF

6. FERTILIZATION AND SOIL AERATION EFFECTS ON GRASSLAND PRIMARY PRODUCTIVITY AND SPECIES DIVERSITY IN A MEADOW STEPPE, NORTHERN CHINA

Author

Z. Wie, R. Zhang, M.P. Schellenberg, S. Lv, Y. Bai, and R. Yan

Subjects
geography, geography.geographical_feature_category, Human fertilization, Agronomy, Meadow steppe, Species diversity, Environmental science, Aeration, China, Agronomy and Crop Science, Ecology, Evolution, Behavior and Systematics, Grassland, Primary productivity
Published
2020
Full Text
View/download PDF

10. Sestamibi Single-Positron Emission Computed Tomography/Diagnostic-quality Computed Tomography for the localization of abnormal parathyroid glands in patients with primary hyperparathyroidism: What clinicopathologic factors affect its accuracy?

Author

J, Yang, H, Wang, J, Zhang, W, Xu, W, Weng, S, Lv, and M, Dong

Subjects
Male, Parathyroidectomy, Single Photon Emission Computed Tomography Computed Tomography, Phosphorus, Middle Aged, Hyperparathyroidism, Primary, Severity of Illness Index, Parathyroid Glands, Parathyroid Neoplasms, Dimensional Measurement Accuracy, Parathyroid Hormone, Preoperative Care, Humans, Calcium, Female, Correlation of Data, Retrospective Studies
Abstract

Sestamibi Single-Positron Emission Computed Tomography/Diagnostic-quality Computed Tomography (MIBI-SPECT/CT) is a common technology used for primary hyperparathyroidism (PHPT) localization in clinical practice. However, the clinicopathologic factors affecting the accuracy of MIBI-SPECT/CT and the potential limitations remain unclear.Retrospectively enrolled PHPT patients (n = 280) were analyzed from August 2017 to December 2019.Of 96 patients with PHPT (mean age, 54 years; 63 females), 17 had discordance between MIBI-SPECT/CT and intraoperative findings. Among the 17 patients with discordance, 58.8% had major discordance, which occurred in most patients with multigland disease (MGD). Compared with concordant patients, discordant patients exhibited increased frequencies of autoimmune thyroid disease (29.4% vs 10.1%, p = 0.035), MDG (41.2% vs 3.8%, p = 0.035), higher PTH (296 pg/mL vs 146 pg/mL; p = 0.012),and lower phosphorus levels (0.77 mmol/L vs 0.90 mmol/L; p = 0.024). MDG (odds ratio [OR], 16.95; 95% CI 2.10-142.86), parathyroid lesion size of 12 mm or less (OR, 6.93; 95% CI 1.41-34.10), and a PTH level higher than 192.5 pg/mL (OR, 12.66; 95% CI 2.17-71.43) were independently associated with discordant MIBI-SPECT/CT results.MGD was most strongly associated with discordance between MIBI-SPECT/CT and intraoperative findings followed by a PTH level higher than 192.5 pg/mL and parathyroid lesion size of 12 mm or less. Surgeons should recognize these potential limitations, which may improve the preoperative procedure by encouraging further localization imaging and promptly facilitate intraoperative troubleshooting.

Published
2020

11. Effects of circRNA_103993 on the proliferation and apoptosis of NSCLC cells through miR-1271/ERG signaling pathway

Author

Y-S, Lv, C, Wang, L-X, Li, S, Han, and Y, Li

Subjects
MicroRNAs, Lung Neoplasms, Transcriptional Regulator ERG, Carcinoma, Non-Small-Cell Lung, Humans, Apoptosis, RNA, Circular, Cells, Cultured, Cell Proliferation, Signal Transduction
Abstract

Non-small cell lung cancer (NSCLC) accounts for more than 80% of lung cancer. CircRNA is a new type of non-coding RNA. CircRNA was found to be deeply involved in the regulation of NSCLC cells. However, the principle of CircRNA regulating NSCLC cells needs to be further explored.The relative mRNA expression levels of CircRNA_103993, miR-1271 and ERG were detected by quantificational real-time polymerase chain reaction (qRT-PCR) in NSCLC cells and human bronchial epithelial cell line HBE. Cell proliferation was detected by the Cell Counting Kit (CCK8) when NSCLC cells were transfected with si-CircRNA_103993, si-NC, miR-1271 mimics, miR-NC, LV-ERG, respectively. The apoptotic rate of NSCLC cells was measured by apoptotic assay and flow Cytometry. The relative mRNA and protein expression levels of PCNA and caspase-3 were detected by Western blot and qRT-PCR.CircRNA_103993 and ERG were significantly up-regulated while miR-1271 was significantly down-regulated in NSCLC cells. Knockdown of CircRNA_103993 and high expression of miR-1271 significantly inhibited NSCLC cell proliferation and promoted apoptosis. The double luciferin report showed that CircRNA_103993 served as a sponge of miR-1271 and miR-1271 could directly target ERG in NSCLC cells. More importantly, low expression of CircRNA_103993 increased the expression level of miR-1271, and high expression of miR-1271 decreased the expression level of ERG. Further experiments showed that miR-1271 inhibitors reversed the effect of si-CircRNA_103993 on proliferation and apoptosis of NSCLC cells. However, miR-1271 mimics significantly promoted the effects of si-CircRNA_103993 on the proliferation and apoptosis. Moreover, LV-ERG reversed the effect of miR-1271 mimics on proliferation and apoptosis of NSCLC cells. However, si-ERG significantly promoted the effects of miR-1271 mimics on the proliferation and apoptosis.CircRNA_103993 was highly expressed in NSCLC cells. CircRNA_103993 regulated proliferation and apoptosis of NSCLC cells by acting as a sponge of miR-1271. The CircRNA_103993 /miR-1271/ ERG axis had an important effect on the proliferation and apoptosis of NSCLC cells. Therefore, CircRNA_103993 may be a target for treating lung cancer.

Published
2020

12. Apelin-13/APJ system delays intervertebral disc degeneration by activating the PI3K/AKT signaling pathway

Author

W, Liu, F, Niu, H, Sha, L-D, Liu, Z-S, Lv, W-Q, Gong, and M, Yan

Subjects
Apelin Receptors, Phosphatidylinositol 3-Kinases, Nucleus Pulposus, Apelin, Humans, Intervertebral Disc Degeneration, Proto-Oncogene Proteins c-akt, Cells, Cultured, Signal Transduction
Abstract

To study the effect of Apelin-13/APJ system on intervertebral disc degeneration and its mechanism.This study detected the expression of APJ in human intervertebral disc tissue with varying degrees of degeneration. IL-1β is used to stimulate the degeneration of nucleus pulposus cells. We used recombinant human Apelin-13 and Ala13 to activate and inhibit the APJ receptor, respectively. The inhibitor LY294002 was used to inhibit the PI3K/AKT signaling pathway. We studied the effects of Apelin-13/APJ system on nucleus pulposus cells and its mechanism by Western blot, RT-PCR, and so on.APJ is lowly expressed in the nucleus pulposus of patients with a high degree of degeneration. IL-1β stimulates the nucleus pulposus cells and reduces the expression of APJ in nucleus pulposus cells. Recombinant human Apelin-13 reduces the degradation of nucleus pulposus extracellular matrix, promotes proliferation, and reduces the levels of apoptosis and inflammation. In addition, the Apelin-13/APJ system increases the expression of PI3K and AKT and activates the PI3K/AKT signaling pathway.Apelin-13/APJ system activates PI3K/AKT signaling pathway activity, reduces the degradation of nucleus pulposus extracellular matrix, promotes proliferation, and reduces the level of apoptosis and inflammation, thus delaying the degeneration of the intervertebral disc.

Published
2020

13. Additivity of standardized ileal digestibility of amino acids in mixed diets containing multiple protein sources for growing pigs fed three crude protein levels

Author

L. Chen, S. Lv, Z. Liu, J. Liu, X. Tang, L. Liu, and H. Zhang

Subjects
0301 basic medicine, food.ingredient, Soya bean, Swine, 03 medical and health sciences, Animal science, food, Food Animals, Ileum, Latin square, Distal ileum, Animals, Amino Acids, Canola, chemistry.chemical_classification, Meal, 0402 animal and dairy science, 04 agricultural and veterinary sciences, Animal Feed, 040201 dairy & animal science, Diet, Amino acid, 030104 developmental biology, chemistry, Animal Nutritional Physiological Phenomena, Digestion, Animal Science and Zoology, Dietary Proteins, CHROMIC OXIDE
Abstract

This study was conducted to investigate the effect of dietary crude protein (CP) levels of semi-purified diets on the additivity of values for standardized ileal digestibility (SID) of amino acids (AA) in mixed diets from multiple protein sources for growing pigs. A total of 28 barrows (initial BW, 66.4 ± 1.3 kg) were surgically fitted with simple T-cannulas at the distal ileum and assigned to a replicated 14 × 4 incomplete Latin square design with 14 diets and 4 periods. The 14 experimental diets consisted of a nitrogen-free diet; a corn-based diet (80 g CP/kg); nine semi-purified diets containing soya bean meal (SBM), canola meal (CM) or corn distillers dried grains with solubles (cDDGS), each type (protein source) of semi-purified diets supplied 80, 120 or 160 g CP/kg, respectively; three mixed diets based on corn, SBM, CM and cDDGS formulated to contain 120, 160 and 200 g CP/kg respectively. Pigs were fed each of the 14 diets during a seven-day period, and ileal digesta were collected from 08:00 a.m to 6:00 p.m on day 6 and 7. Chromic oxide was added as an indigestible marker. Results indicated that the SID of CP and AA were not affected by CP levels (p > .05). Values for SID of AA were additive (p > .05) with the exception of His and Lys; Arg and Lys; Arg, Lys, Thr, Asp, Cys and Gly in the mixed diets containing 120, 160 and 200 g CP/kg respectively (p

Published
2018
Full Text
View/download PDF

14. Advances on the performance and fabrication of low-background PTFE based electronic substrates by surface modification

Author

S J Zhang, Y Y Liu, J P Cheng, and S S Lv

Subjects
History, Computer Science Applications, Education
Abstract

The weak signal from rare event is readily submerged in the background and thus results in substantial challenges in its detection, which spurs researchers to decrease the surroundings background of detectors as low as possible. To this end, a low-background non-adhesive polytetrafluoroethylene (PTFE) flexible copper-clad laminate (PTFE-FCCL) was prepared by surface treatment. Specifically, the PTFE substrate was processed by ion implantation and the transition layer deposition; the adhesion between PTFE and copper of PTFE-FCCL is found to remain stable after barely immersing in liquid nitrogen. Furthermore, the surface morphology and the dielectric properties of the substrate were characterized and tested. The results presented herein offer a novel method to fabricate electronic substrates that can facilitate rare event detection.

Published
2021
Full Text
View/download PDF

15. Xiangshao granules can relieve emotional symptoms in menopausal women: a randomized controlled trial

Author

R Wang, Y Luo, Shao-fen Zhang, H Liu, X Xie, S Lv, Ya-Ping Wang, H Shi, Ruiyi Tang, R Chen, M Xie, Y Ouyang, Q Yu, and Y Zhang

Subjects
Adult, medicine.medical_specialty, 030209 endocrinology & metabolism, Traditional Chinese medicine, Anxiety, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Double-Blind Method, law, Internal medicine, medicine, Humans, Affective Symptoms, Depressive symptoms, Psychiatric Status Rating Scales, 030219 obstetrics & reproductive medicine, Postmenopausal women, business.industry, Obstetrics and Gynecology, General Medicine, Middle Aged, medicine.disease, Menopause, Treatment Outcome, Female, business, Drugs, Chinese Herbal
Abstract

This study aimed to investigate the safety and efficacy of Xiangshao granules for treating emotional disorders in perimenopausal and postmenopausal women. The current investigation was a double-blind, randomized, placebo-controlled, multicenter trial that included 300 perimenopausal and postmenopausal Chinese women aged 40–60 years. Participants received either a placebo (n = 150) or Xiangshao granules (n = 150) for 8 weeks. Outcome measures included Hamilton Depression Rating Scale (HAMD) and Hamilton Anxiety Rating Scale (HAMA) scores, which were assessed at baseline, 4 weeks, and 8 weeks. The primary efficacy variables were changes in HAMD and HAMA scores after 8 weeks. After 8 weeks, the mean HAMD scores decreased from 15.0 to 7.9 in the Xiangshao group and from 16.3 to 10.0 in the placebo group, and the respective mean reductions in HAMA scores were from 16.0 to 8.5 and from 17.1 to 10.9. Clinical improvements in symptoms of both depression and anxiety after 8 weeks differed significantly in the two groups (p Xiangshao granules can relieve symptoms of depression and anxiety significantly and safely.

Published
2020
Full Text
View/download PDF

16. Properties of Surfactant Solution for Foam-Flooding

Author

G. Chen, P. H. Han, S. L. Guo, C. S. Lv, C. Y. Cui, H. S. Liu, and R. B. Cao

Subjects
Surface tension, Oil displacement, chemistry.chemical_classification, Materials science, Pulmonary surfactant, Petroleum engineering, chemistry, Compatibility (mechanics), chemistry.chemical_element, Polymer, Binary system, Nitrogen, Pressure gradient
Abstract

The chemical flooding in Daqing Oilfield has entered the following water flooding stage, and about more than 50% of the crude oil remains in the reservoir. In order to maintain the sustainable and effective development of oilfield, the formulation of chemical flooding system suitable for after chemical flooding is studied. The surfactants in field application at home and abroad were investigated. The foam and interfacial properties of the surfactants were measured through a foam scanner and an interfacial tension tester. The properties of the surfactant system were optimized by using compound method. The injection pressure and oil displacement effect of surfactant system were studied by physical simulation experiment. The results show that the compatibility of DWS or AOS with oilfield sewage and polymer is good, and the foaming property and foam stability of DWS or AOS with polymer binary system are good. The ultra-low interfacial tension is formation between DWS and crude oil under oilfield sewage conditions. The foaming property and foam stability of DWS/AOS or DWS/RFD system are good. When the binary system is aged for three months under the condition of nitrogen, the viscosity retention rate is more than fifty percent. The viscosity stability under the condition of nitrogen is better than that in the air. When the liquid–gas ratio is 1:1, the pressure gradient and displacement effect of foam-flooding are the best. This gives a method to improve oil recovery after chemical flooding and provides a basic guarantee for oilfield development.

Published
2019
Full Text
View/download PDF

17. MiR-15a-3p suppresses the growth and metastasis of ovarian cancer cell by targeting Twist1

Author

B, Fan, L-P, Chen, Y-H, Yuan, H-N, Xiao, X-S, Lv, and Z-Y, Xia

Subjects
Ovarian Neoplasms, Twist-Related Protein 1, Down-Regulation, Mice, Nude, Nuclear Proteins, Xenograft Model Antitumor Assays, Up-Regulation, MicroRNAs, Cell Line, Tumor, Gene Knockdown Techniques, Animals, Humans, Female, Neoplasm Metastasis, RNA, Small Interfering, Cell Proliferation
Abstract

To investigate the roles of miR-15a-3p in ovarian cancer cell growth and metastasis.A key role of miR-15a-3p was identified via gene profiling and bioinformatics analysis. The impact of miR-15a-3p on ovarian cancer cell growth, migration and invasion was measured by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT), wound-healing and transwell invasion assays. Bioinformatics and luciferase reporter assays were applied to identify that twist family BHLH transcription factor 1 (Twist1) was the target gene of miR-15a-3p. The miR-15a-3p level and the expression of Twist1 were detected using quantitative Real-time polymerase chain reaction (qRT-PCR) assay. The expressions of N-cadherin and E-cadherin were measured by immunofluorescence staining. Small interfering RNA targeting Twist1 and pCDNA3.1 containing Twist1 were applied to decrease and increase the expression of Twist1, respectively.miR-15a-3p was markedly down-regulated in ovarian cancer. Exogenous up-regulation of miR-15a-3p inhibited the growth, colony formation, migration and invasion of ovarian cancer cell in vitro. Furthermore, a xenograft model indicated that miR-15a-3p inhibited tumour growth and the metastatic potential of ovarian cancer cell in vivo. We found that Twist1 was the direct target of miR-15a-3p in ovarian cancer and that its expression was negatively correlated with the level of miR-15a-3p in ovarian cancer tissues. Up-regulation of miR-15a-3p rescued the inhibitory impact of miR-15a-3p on ovarian cancer cell growth, migration and invasion. Finally, down-regulation of Twist1 mimicked the suppressive effects of miR-15a-3p on ovarian cancer cell.We demonstrated that miR-15a-3p is down-regulated in ovarian cancer. Up-regulation of miR-15a-3p restrains the growth and metastasis of ovarian cancer cell by regulating Twist1.

Published
2019

18. Chronic perfluorooctanesulfonic acid exposure disrupts lipid metabolism in zebrafish

Author

Changjiang Huang, S Nie, Dongren Yang, Jiangfei Chen, Q Dong, Y Cui, S Lv, and J Liu

Subjects
Male, 0301 basic medicine, medicine.medical_specialty, Perfluorooctanesulfonic acid, Health, Toxicology and Mutagenesis, 010501 environmental sciences, Biology, Real-Time Polymerase Chain Reaction, Toxicology, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, Microscopy, Electron, Transmission, Internal medicine, Intestine, Small, medicine, Animals, Chronic toxicity, Zebrafish, 0105 earth and related environmental sciences, Diacylglycerol kinase, Fluorocarbons, Endoplasmic reticulum, Lipid metabolism, General Medicine, Metabolism, Lipid Metabolism, biology.organism_classification, Insulin receptor, 030104 developmental biology, Endocrinology, Alkanesulfonic Acids, Liver, chemistry, biology.protein, Female
Abstract

Perfluorooctanesulfonic acid (PFOS), a ubiquitous contaminant, has been used in various industrial applications. Currently few studies have documented the effects of chronic PFOS exposure on lipid metabolism, especially in aquatic organisms. The present study defined the effects of chronic exposure to low level of PFOS on lipid metabolism in F0 adult zebrafish and F1 offspring. Our findings revealed a severe fatty degeneration in the liver of F0 males treated with 0.5 μM PFOS and significant ultrastructure changes associated with substance transport or metabolism in liver and intestines (abnormal mitochondria and endoplasmic reticulum, disordered arrangement of inner microvilli within intracellular canaliculus). To address the potential trans-generational effects of PFOS exposure, the early gene expression related to lipid metabolism was measured by real-time quantitative polymerase chain reaction in F1 derived from chronically exposed parental fish. The results indicated that lepa (leptin α), kiss1 (kisspeptins), xdh (xanthine dehydrogenases), and insr (insulin receptor) were significantly upregulated in F1 while dgat1b (diacylglycerol O-acyltransferase), hb9 (motor neuron/pancreas homeobox), and Apoa1 (apolipoprotein A-I) were downregulated. These findings provided evidence that PFOS chronic exposure adversely impacts lipid metabolism in both F0 and F1 and demonstrated the validity of using zebrafish as an alternative model for PFOS chronic toxicity screening.

Published
2016
Full Text
View/download PDF

19. Numerical simulation analysis of coal rock crushed by disc cutter based on ABAQUS

Author

J. Wang, X. Zhang, S. Lv, and Z. G. Guo

Subjects
Computer simulation, business.industry, Disc cutter, Coal, Geotechnical engineering, business, Geology
Abstract

In view of the lack of research on the mechanism of disc cutter cutting coal rock during the tunnelling process of coal mine rescue tunnel equipment, the ABAQUS software was used to establish the finite element model of single disc cutter crushing coal rock, and the influence of penetration and cutting speed on the rock breaking force during the process of disc cutter crushing coal rock was analyzed. The results show that the average cutting force increases linearly with the penetration and cutting speed. The maximum vertical force of the disc cutter at a penetration of 5mm is 2.6 times that at a penetration of 2mm. The impact of the disc cutter cutting force at a penetration of 3mm is obvious. The average rolling force at a cutting speed of 0.8 rad/s is twice that of a cutting speed of 0.2 rad/s. The impact of the disc cutter cutting force at a cutting speed of 0.5rad/s is obvious. Comprehensively considering the influence of penetration and cutting speed on the average value and fluctuation range of disc cutter cutting force, choosing a moderately large penetration and a large cutting speed parameter combination will help to achieve rapid and safe coal mine emergency rescue tunnelling. The method in this paper provides a basis for the optimization of the cutterhead tunnelling parameters during coal rock cutting.

Published
2021
Full Text
View/download PDF

21. Comparison study on microstructure and mechanical properties of Ti-6Al-4V alloys fabricated by powder-based selective-laser-melting and sintering methods

Author

S. Lv, Q. Yan, Nan Kang, Shufeng Li, Bo Chen, Katsuyoshi Kondoh, Xin Lin, and J.S. Li

Subjects
Materials science, Mechanical Engineering, Alloy, Sintering, Modulus, engineering.material, Lath, Condensed Matter Physics, Microstructure, Mechanics of Materials, Phase (matter), engineering, General Materials Science, Lamellar structure, Selective laser melting, Composite material
Abstract

To better understand the structure-mechanical properties relation of additively manufactured Ti-6Al-4V (Ti64) alloys, a comparison study was performed on Ti64 alloys fabricated by powder-based selective laser melting (SLM) and sintering methods. It is found that the SLM Ti64 alloy has prior β grains filled with (lath α + needle α′) structure. While Ti64 alloys sintered over and below β → α transformation temperature have widmanstatten α + β and lamellar α + β structure, respectively. The SLM Ti64 alloy has higher strength and hardness than sintered alloys, but possesses similar Young's modulus to the spark plasma sintered alloy. The mechanisms leading to the different mechanical properties are discussed based on phase compositions and contents. The results suggest that SLM Ti64 alloys potentially have better mechanical performance compared with those fabricated by conventional sintering methods.

Published
2020
Full Text
View/download PDF

22. Loss of function mutation of mouse Snap29 on a mixed genetic background phenocopy abnormalities found in CEDNIK and 22q11.2 Deletion Syndrome patients

Author

Vafa Keser, Pierre Lachapelle, J.-F. Boisclair Lachance, Sabrina Shameen Alam, Loydie A. Jerome-Majewska, Jeffrey A. Golden, S. Lv, Amanpreet Kaur, Z. T. Fang, Eleonora Scarlata, Cristian O'Flaherty, and Youngshin Lim

Subjects
Phenocopy, Genetics, 0303 health sciences, Ichthyosis, Skin abnormality, Hemizygosity, Biology, medicine.disease, Phenotype, Loss of function mutation, 03 medical and health sciences, 0302 clinical medicine, medicine, Deletion syndrome, Keratoderma, 030217 neurology & neurosurgery, 030304 developmental biology
Abstract

Synaptosomal-associated protein 29 (SNAP29) is a member of the SNARE family of proteins involved in maintenance of various intracellular protein trafficking pathways. SNAP29 maps to the 22q11.2 region and is deleted in 90% of patients with 22q11.2 deletion syndrome (22q11.2DS). However, the contribution of hemizygosity of SNAP29 to developmental abnormalities in 22q11.2DS remains to be determined. Mutations in SNAP29 are responsible for the developmental syndrome called CEDNIK (cerebral dysgenesis, neuropathy, ichthyosis, and keratoderma). On an inbred C57Bl/6J genetic background, only the ichthyotic skin defect associated with CEDNIK was reported. In this study, we show that loss of function mutation of Snap29 on a mixed genetic background not only models skin abnormalities found in CEDNIK, but also phenocopy ophthalmological, neurological, and motor defects found in these patients and a subset of 22q11.2DS patients. Thus, our findings indicate that mouse models of human syndromes should be analyzed on a mixed genetic background. Our work also reveals an unanticipated requirement for Snap29 in male fertility, and support contribution of hemizygosity for SNAP29 to the phenotypic spectrum of abnormalities found in 22q11.2DS patients.

Published
2019
Full Text
View/download PDF

23. Elemental Mapping of Silicone Rubber Composites by Laser-induced Breakdown Spectroscopy (LIBS)

Author

X. Hong, W. Wei, Z. D. Jia, N.X. Wang, X. Li, X. L. Wang, J. W. Ai, and Q. S. Lv

Subjects
Materials science, Morphology (linguistics), medicine.medical_treatment, Silicone rubber, Laser, Ablation, Spectral line, law.invention, chemistry.chemical_compound, chemistry, law, Agglomerate, medicine, Laser-induced breakdown spectroscopy, Composite material, Intensity (heat transfer)
Abstract

Elemental mapping of 2D and 3D surface distributions of inorganic filler in silicone rubber composites were obtained to analyze the information on the types and locations of the agglomerates. The elemental mapping of surface distribution in the samples were plotted by selecting the characteristic line strength of the elements, such as C, O, Al, Na, K, etc. Compared with the distribution of O and the accumulation of Al, the location of ATH filler and Al 2 O 3 particles can be characterized by the spectral line intensity distribution of Al. The identification of the agglomerates was confirmed with SEM/EDS. In addition, the surface distribution of Na is similar to K, which reflect the locations of contamination on the surface of the sample. This indicates that the 2D element mapping by LIBS can characterize the distribution of insulator contamination. On the basis of the strong linear relationship between the number of laser pulse bombardment and the depth of ablation, The 3D spatial information was obtained by continuously accumulating the intensity distribution of a single bombardment. The content and locations of Al abruptly decay and eventually stabilize with the increase of the depth of ablation. Finally, before and after ablation of the morphology were compared by the SEM/EDS. The lower the content of ATH filler, the more ablated the bottom of the ablation pit. LIBS has a great advantage in scanning speed and scanning area comparing to EDS/SEM. The obtained elemental images provide a valuable basis for further interpretation.

Published
2018
Full Text
View/download PDF

24. Viperin is induced following toll-like receptor 3 (TLR3) ligation and has a virus-responsive function in human trophoblast cells

Author

He-Feng Huang, Yutaka Osuga, J. Wang, S. Lv, Y. Zhu, D. Chen, Kaori Koga, Y. Wu, Y. Fang, and B. Wang

Subjects
Oxidoreductases Acting on CH-CH Group Donors, Placenta, viruses, Biology, Pregnancy, RNA interference, Interferon, medicine, Humans, RNA, Double-Stranded, Toll-like receptor, Messenger RNA, Proteins, Obstetrics and Gynecology, Trophoblast, RNA, Interferon-beta, Virology, Toll-Like Receptor 3, Trophoblasts, Cell biology, Pregnancy Trimester, First, Poly I-C, medicine.anatomical_structure, Reproductive Medicine, Viperin, TLR3, Female, RNA Interference, Developmental Biology, medicine.drug
Abstract

Introduction Viperin, a virus-inducible antiviral protein, has been reported to inhibit the replication of a variety of viruses. However, its expression and function in trophoblast cells remains unclear. Toll-like receptor 3 (TLR3) is a key component of the innate immune system that recognizes viral double-stranded RNA and triggers immune reactions by producing type I interferon. We hypothesized that viperin inhibits the replication of human cytomegalovirus (HCMV) in trophoblast cells. Methods In situ examinations of viperin expression was conducted in the human first-trimester placenta by immunohistochemical staining. Using a human trophoblast cell culture system, we studied the effect of TLR-3 ligation on viperin expression by treating trophoblasts with polyinosinic-polycytidylic acid [Poly (I: C)] (a synthetic double-stranded RNA, which mimics viral RNA). Viperin mRNA and protein expression were evaluated by real-time PCR and Western blot analysis. In a HCMV infected Swan 71 cell model, HCMV immediate early 1 (IE1) protein mRNA expression was evaluated by real-time PCR after viperin RNA interference. Results Viperin was localized in trophoblast cells. Poly (I: C) induced viperin expression in a dosage and time-dependent manner. Blocking of TLR3 signaling by neutralizing antibody against IFN-β abolished the stimulation of viperin expression. After HCMV infection, expression of viperin mRNA and protein was unregulated. HCMV IE1 mRNA expression was significantly inhibited by viperin RNA interference. Discussion Viperin is a virus-responsive protein that is constitutively expressed in human trophoblast cells. However, contrary to our hypothesis, viperin facilitates HCMV replication post infection.

Published
2015
Full Text
View/download PDF

25. High Statistics Measurement of the Positron Fraction in Primary Cosmic Rays of 0.5–500 GeV with the Alpha Magnetic Spectrometer on the International Space Station

Author

K. H. Guo, A. Lebedev, Dong-Chul Son, Y. Y. Fan, Massimo Gervasi, L. Tao, M. Capell, L. Accardo, C. Sbarra, Yun Shi, Antje Putze, B. Coste, I. Guerri, H. Jinchi, D. Haas, V. Vagelli, G. La Vacca, A. Malinin, A. Piluso, R. Pilastrini, I. Cernuda, I. Lazzizzera, Carlos Díaz, W. De Boer, David Maurin, E. Valente, M. Bourquin, Laurent Derome, D. Grandi, M. Xie, I. Gebauer, X. M. Qi, G. Schwering, J. Bazo, P. G. Rancoita, M. S. Krafczyk, Wei Li, C. Mañá, E. Fiandrini, J. C. Marin, W. Gillard, T. Urban, V. Choutko, B. Bertucci, W. H. Sun, Q. Meng, R. Q. Xiong, Franck Cadoux, P. Nunes, Teimuraz Lomtadze, Fabrizio Giulio Luca Pilo, C. Türkoʇlu, G. Castellini, M. Bizzarri, Won Kyu Calvin Sun, P. Goglov, Mayda Velasco, Federico Cindolo, W. Y. Jang, S. S. Vaurynovich, H. S. Chen, F. Spinella, V. Cascioli, Benjamin Monreal, N. Nikonov, Liqiu Wang, Veronica Bindi, Kwangsoo Kim, Chia-Hui Lin, M. J. Chae, C. Guandalini, M. Duranti, E. Pedreschi, G. Boella, Sadakazu Haino, E. Laudi, Y. J. Yu, Lucio Rossi, S. Xie, G. Coignet, M. Paniccia, Xiaoping Wang, G. Laurenti, S. Zeissler, D. Schuckardt, V. Poireau, Q. H. Ye, J. Gong, F. Giovacchini, Roald Z. Sagdeev, Luca Morescalchi, D. Aisa, C. Goy, R. J. García-López, F. Palmonari, S. Della Torre, X. W. Tang, M. Pauluzzi, Samuel C.C. Ting, Y. H. Chang, Zhixiang Tang, Fei Zhou, F. Massera, Arturo Alejandro Menchaca-Rocha, S. M. Schmidt, G. Ambrosi, V. Vitale, M. Orcinha, J. Q. Li, Valery Zhukov, J. P. Vialle, K. Bollweg, Gongming Xin, H. L. Li, Markus Battarbee, Paolo Zuccon, L. Di Masso, G. Gallucci, L. Basara, G. Volpini, R. Clavero, T. Siedenburg, A. Rozhkov, E. Finch, J. H. Zhang, Davide Rozza, S. Lim, I. Rodríguez, L. Farnesini, S. Borsini, Claudio Corti, A. Fiasson, Z. M. Zheng, A. Obermeier, K. Andeen, A. Contin, D. D'Urso, Mingming Yang, J. Feng, M. Pohl, Z. L. Weng, D. Rapin, V. Plyaskin, E. Postaci, Zheng Wang, X. Y. Shi, Philipp Azzarello, Matthias Heil, Mauro Tacconi, B. S. Shan, J. Casaus, M. Graziani, T. Kirn, G. M. Cheng, Matteo Boschini, J. Wienkenhöver, N. Masi, F. Luo, A. I. Chen, Zhiqi Huang, L. Barrin, M. B. Demirköz, A. Papi, Z. H. He, F. Nozzoli, C. Zurbach, A. Alvino, Hengchang Liu, P. Lipari, S. Bizzaglia, T. X. Li, Varlen Grabski, C. Pizzolotto, T. Eronen, X. Xia, C. Consolandi, A. Schulz von Dratzig, K. Kanishev, Yu. Galaktionov, Lin Cheng, Nicola Tomassetti, Z. Q. Yu, D. C. Mo, Y. Li, W. Xu, Roberto Battiston, J. Berdugo, K. C. Han, S. C. Lee, H. T. Lee, Dong Liu, Behcet Alpat, R. Pereira, Q. L. Wang, S. Di Falco, H. Yi, B. Borgia, F. Spada, J. J. Torsti, S. Pensotti, Antonino Zichichi, S. M. Ting, C. Delgado, S. Schael, A. Ghelfi, S. S. Lv, J. Hoffman, N. Attig, F. Cervelli, Zhijun Zhang, P. Mott, J. Sandweiss, Henning Gast, Tim Martin, Y. H. Shan, G. Scolieri, J. Q. Ni, C. H. Chung, A. Oliva, M. T. Zhang, U. Becker, Fernando Barão, J. S. Ricol, M. Behlmann, D. Cerreta, Ningsheng Xu, Thomas Lippert, C. Leluc, F. J. Eppling, B. Beischer, V. Bonnivard, H. Y. Chou, R. Henning, R. D. Majka, M. Dai, Z. Cui, O. Kounina, G. Rybka, M. Müller, H. Wu, P. Saouter, Peter H. Fisher, K. Luebelsmeyer, D. Tescaro, M. Aguilar, Ruiguang Wang, F. Dimiccoli, K. Whitman, E. Choumilov, R. Kossakowski, G. N. Kim, H. L. Zhuang, A. Barrau, M. J. Lu, A. Bartoloni, Bruce Rafael Mellado Garcia, Luísa Arruda, M. Lolli, C. P. Tang, S. Kunz, A. Eline, Timothy H. Hsieh, J. Y. Shi, J. Yang, A. Chikanian, Gianpaolo Carosi, Changgi Huh, J. Z. Luo, Z. Y. Li, Lucio Quadrani, M. Habiby, A. Bachlechner, X. B. Zhang, Eun-Suk Seo, Ying Lu, S. Rosier-Lees, V. Koutsenko, Eino Valtonen, Z. H. Li, Qiang Li, J. D. Burger, W. J. Du, K. Y. Wu, Manuela Vecchi, C. Vannini, P. von Doetinchem, X. D. Cai, Giuseppe Levi, G. Martinez, C. Palomares, C. Clark, Andrei Kounine, Q. Yan, G. Bigongiari, S. Caroff, N. Zimmermann, M. Incagli, Maria Ionica, Azzarello, Philipp, Bourquin, Maurice, Cadoux, Franck, Haas, Daniel, Habiby Alaoui, Marion, Leluc, Catherine, Li, Yang, Paniccia, Mercedes, Pohl, Martin, Rapin, Divic Jean, Saouter, Pierre, Accardo, L, Aguilar, M, Aisa, D, Alpat, B, Alvino, A, Ambrosi, G, Andeen, K, Arruda, L, Attig, N, Azzarello, P, Bachlechner, A, Barao, F, Barrau, A, Barrin, L, Bartoloni, A, Basara, L, Battarbee, M, Battiston, R, Bazo, J, Becker, U, Behlmann, M, Beischer, B, Berdugo, J, Bertucci, B, Bigongiari, G, Bindi, V, Bizzaglia, S, Bizzarri, M, Boella, G, de Boer, W, Bollweg, K, Bonnivard, V, Borgia, B, Borsini, S, Boschini, M, Bourquin, M, Burger, J, Cadoux, F, Cai, X, Capell, M, Caroff, S, Carosi, G, Casaus, J, Cascioli, V, Castellini, G, Cernuda, I, Cerreta, D, Cervelli, F, Chae, M, Chang, Y, Chen, A, Chen, H, Cheng, G, Cheng, L, Chikanian, A, Chou, H, Choumilov, E, Choutko, V, Chung, C, Cindolo, F, Clark, C, Clavero, R, Coignet, G, Consolandi, C, Contin, A, Corti, C, Coste, B, Cui, Z, Dai, M, Delgado, C, Della Torre, S, Demirköz, M, Derome, L, Di Falco, S, Di Masso, L, Dimiccoli, F, Díaz, C, von Doetinchem, P, Du, W, Duranti, M, D’Urso, D, Eline, A, Eppling, F, Eronen, T, Fan, Y, Farnesini, L, Feng, J, Fiandrini, E, Fiasson, A, Finch, E, Fisher, P, Galaktionov, Y, Gallucci, G, García, B, García López, R, Gast, H, Gebauer, I, Gervasi, M, Ghelfi, A, Gillard, W, Giovacchini, F, Goglov, P, Gong, J, Goy, C, Grabski, V, Grandi, D, Graziani, M, Guandalini, C, Guerri, I, Guo, K, Haas, D, Habiby, M, Haino, S, Han, K, He, Z, Heil, M, Henning, R, Hoffman, J, Hsieh, T, Huang, Z, Huh, C, Incagli, M, Ionica, M, Jang, W, Jinchi, H, Kanishev, K, Kim, G, Kim, K, Kirn, T, Kossakowski, R, Kounina, O, Kounine, A, Koutsenko, V, Krafczyk, M, Kunz, S, LA VACCA, G, Laudi, E, Laurenti, G, Lazzizzera, I, Lebedev, A, Lee, H, Lee, S, Leluc, C, Levi, G, Li, H, Li, J, Li, Q, Li, T, Li, W, Li, Y, Li, Z, Lim, S, Lin, C, Lipari, P, Lippert, T, Liu, D, Liu, H, Lolli, M, Lomtadze, T, Lu, M, Lu, Y, Luebelsmeyer, K, Luo, F, Luo, J, Lv, S, Majka, R, Malinin, A, Mañá, C, Marín, J, Martin, T, Martínez, G, Masi, N, Massera, F, Maurin, D, Menchaca Rocha, A, Meng, Q, Mo, D, Monreal, B, Morescalchi, L, Mott, P, Müller, M, Ni, J, Nikonov, N, Nozzoli, F, Nunes, P, Obermeier, A, Oliva, A, Orcinha, M, Palmonari, F, Palomares, C, Paniccia, M, Papi, A, Pauluzzi, M, Pedreschi, E, Pensotti, S, Pereira, R, Pilastrini, R, Pilo, F, Piluso, A, Pizzolotto, C, Plyaskin, V, Pohl, M, Poireau, V, Postaci, E, Putze, A, Quadrani, L, Qi, X, Rancoita, P, Rapin, D, Ricol, J, Rodríguez, I, Rosier Lees, S, Rossi, L, Rozhkov, A, Rozza, D, Rybka, G, Sagdeev, R, Sandweiss, J, Saouter, P, Sbarra, C, Schael, S, Schmidt, S, Schuckardt, D, Schulz von Dratzig, A, Schwering, G, Scolieri, G, Seo, E, Shan, B, Shan, Y, Shi, J, Shi, X, Shi, Y, Siedenburg, T, Son, D, Spada, F, Spinella, F, Sun, W, Tacconi, M, Tang, C, Tang, X, Tang, Z, Tao, L, Tescaro, D, Ting, S, Tomassetti, N, Torsti, J, Türkoğlu, C, Urban, T, Vagelli, V, Valente, E, Vannini, C, Valtonen, E, Vaurynovich, S, Vecchi, M, Velasco, M, Vialle, J, Vitale, V, Volpini, G, Wang, L, Wang, Q, Wang, R, Wang, X, Wang, Z, Weng, Z, Whitman, K, Wienkenhöver, J, Wu, H, Wu, K, Xia, X, Xie, M, Xie, S, Xiong, R, Xin, G, Xu, N, Xu, W, Yan, Q, Yang, J, Yang, M, Ye, Q, Yi, H, Yu, Y, Yu, Z, Zeissler, S, Zhang, J, Zhang, M, Zhang, X, Zhang, Z, Zheng, Z, Zhou, F, Zhuang, H, Zhukov, V, Zichichi, A, Zimmermann, N, Zuccon, P, Zurbach, C, L. Accardo, M. Aguilar, D. Aisa, B. Alpat, A. Alvino, G. Ambrosi, K. Andeen, L. Arruda, N. Attig, P. Azzarello, A. Bachlechner, F. Barao, A. Barrau, L. Barrin, A. Bartoloni, L. Basara, M. Battarbee, R. Battiston, J. Bazo, U. Becker, M. Behlmann, B. Beischer, J. Berdugo, B. Bertucci, G. Bigongiari, V. Bindi, S. Bizzaglia, M. Bizzarri, G. Boella, W. d. Boer, K. Bollweg, V. Bonnivard, B. Borgia, S. Borsini, M. J. Boschini, M. Bourquin, J. Burger, F. Cadoux, X. D. Cai, M. Capell, S. Caroff, G. Carosi, J. Casau, V. Cascioli, G. Castellini, I. Cernuda, D. Cerreta, F. Cervelli, M. J. Chae, Y. H. Chang, A. I. Chen, H. Chen, G. M. Cheng, H. S. Chen, L. Cheng, A. Chikanian, H. Y. Chou, E. Choumilov, V. Choutko, C. H. Chung, F. Cindolo, C. Clark, R. Clavero, G. Coignet, C. Consolandi, A. Contin, C. Corti, B. Coste, Z. Cui, M. Dai, C. Delgado, S. D. Torre, M. B. Demirkoz, L. Derome, S. D. Falco, L. D. Masso, F. Dimiccoli, C. Diaz, P. v. Doetinchem, W. J. Du, M. Duranti, D. D'Urso, A. Eline, F. J. Eppling, T. Eronen, Y. Y. Fan, L. Farnesini, J. Feng, E. Fiandrini, A. Fiasson, E. Finch, P. Fisher, Y. Galaktionov, G. Gallucci, B. Garcia, R. Garcia-Lopez, H. Gast, I. Gebauer, M. Gervasi, A. Ghelfi, W. Gillard, F. Giovacchini, P. Goglov, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, C. Guandalini, I. Guerri, K. H. Guo, D. Haa, M. Habiby, S. Haino, K. C. Han, Z. H. He, M. Heil, R. Henning, J. Hoffman, T. H. Hsieh, Z. C. Huang, C. Huh, M. Incagli, M. Ionica, W. Y. Jang, H. Jinchi, K. Kanishev, G. N. Kim, K. S. Kim, T. Kirn, R. Kossakowski, O. Kounina, A. Kounine, V. Koutsenko, M. S. Krafczyk, S. Kunz, G. L. Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, C. Leluc, G. Levi, H. L. Li, J. Q. Li, Q. Li, T. X. Li, W. Li, Y. Li, Z. H. Li, Z. Y. Li, S. Lim, C. H. Lin, P. Lipari, T. Lippert, D. Liu, H. Liu, M. Lolli, T. Lomtadze, M. J. Lu, Y. S. Lu, K. Luebelsmeyer, F. Luo, J. Z. Luo, S. S. Lv, R. Majka, A. Malinin, C. Mana, J. Marin, T. Martin, G. Martinez, N. Masi, F. Massera, D. Maurin, A. Menchaca-Rocha, Q. Meng, D. C. Mo, B. Monreal, L. Morescalchi, P. Mott, M. Muller, J. Q. Ni, N. Nikonov, F. Nozzoli, P. Nune, A. Obermeier, A. Oliva, M. Orcinha, F. Palmonari, C. Palomare, M. Paniccia, A. Papi, M. Pauluzzi, E. Pedreschi, S. Pensotti, R. Pereira, R. Pilastrini, F. Pilo, A. Piluso, C. Pizzolotto, V. Plyaskin, M. Pohl, V. Poireau, E. Postaci, A. Putze, L. Quadrani, X. M. Qi, P. G. Rancoita, D. Rapin, J. S. Ricol, I. Rodriguez, S. Rosier-Lee, L. Rossi, A. Rozhkov, D. Rozza, G. Rybka, R. Sagdeev, J. Sandwei, P. Saouter, C. Sbarra, S. Schael, S. M. Schmidt, D. Schuckardt, A. S. von, G. Schwering, G. Scolieri, E. S. Seo, B. S. Shan, Y. H. Shan, J. Y. Shi, X. Y. Shi, Y. M. Shi, T. Siedenburg, D. Son, F. Spada, F. Spinella, W. Sun, W. H. Sun, M. Tacconi, C. P. Tang, X. W. Tang, Z. C. Tang, L. Tao, D. Tescaro, S. C. C., S. M. Ting, N. Tomassetti, J. Torsti, C. Turkoglu, T. Urban, V. Vagelli, E. Valente, C. Vannini, E. Valtonen, S. Vaurynovich, M. Vecchi, M. Velasco, J. P. Vialle, V. Vitale, G. Volpini, L. Q. Wang, Q. L. Wang, R. S. Wang, X. Wang, Z. X. Wang, Z. L. Weng, K. Whitman, J. Wienkenhover, H. Wu, K. Y. Wu, X. Xia, M. Xie, S. Xie, R. Q. Xiong, G. M. Xin, N. S. Xu, W. Xu, Q. Yan, J. Yang, M. Yang, Q. H. Ye, H. Yi, Y. J. Yu, Z. Q. Yu, S. Zeissler, J. H. Zhang, M. T. Zhang, X. B. Zhang, Z. Zhang, Z. M. Zheng, F. Zhou, H. L. Zhuang, V. Zhukov, A. Zichichi, N. Zimmermann, P. Zuccon, C. Zurbach, Istituto Nazionale di Fisica Nucleare, Sezione di Perugia (INFN, Sezione di Perugia), Istituto Nazionale di Fisica Nucleare (INFN), Centro de Investigaciones Energéticas Medioambientales y Tecnológicas [Madrid] (CIEMAT), Institut für Experimentelle Kernphysik [Karlsruhe] (EKP), Karlsruher Institut für Technologie (KIT), Jülich Aachen Research Alliance (JARA), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), CERN [Genève], Istituto Nazionale di Fisica Nucleare, Sezione di Roma 3 (INFN, Sezione di Roma 3), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), University of Turku, Massachusetts Institute of Technology (MIT), INFN Sezione di Pisa (INFN Sezione di Pisa), University of Hawai'i [Honolulu] (UH), Istituto Nazionale di Fisica Nucleare, Sezione di Milano (INFN), Karlsruhe Institute of Technology (KIT), NASA Johnson Space Center (JSC), NASA, Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Département de Physique Nucléaire et Corpusculaire [Genève] (DPNC), Université de Genève (UNIGE), Istituto Nazionale di Ottica [Firenze] (INO-CNR), Consiglio Nazionale delle Ricerche (CNR), Istituto Nazionale di Fisica Nucleare [Pisa] (INFN), EWHA Womans University (EWHA), National Central University [Taiwan] (NCU), Academia Sinica, Istituto Nazionale di Fisica Nucleare, Sezione di Bologna (INFN, Sezione di Bologna), Laboratoire Univers et Particules de Montpellier (LUPM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Montpellier 2 - Sciences et Techniques (UM2), and AMS

Subjects
Astrophysics and Astronomy, [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astrophysics::High Energy Astrophysical Phenomena, General Physics and Astronomy, cosmic rays studies, Cosmic ray, Electron, ddc:500.2, 7. Clean energy, Space mission, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Nuclear physics, Physics and Astronomy (all), FIS/05 - ASTRONOMIA E ASTROFISICA, Positron, International Space Station, Alpha Magnetic Spectrometer, ddc:550, Dark matter, ASTROPARTICLE PHYSICS, AMS, Cosmic rays, Positron fraction, antimatter and dark matter, positrons, Physics, Range (particle radiation), ta115, Magnetic spectrometer, ELECTRONS, Cosmic rays, Positron fraction, International Space Station, FIS/01 - FISICA SPERIMENTALE, Physics::Accelerator Physics, Satellite, High Energy Physics::Experiment, Particle Physics - Experiment, Energy (signal processing)
Abstract

A precision measurement by AMS of the positron fraction in primary cosmic rays in the energy range from 0.5 to 500 GeV based on 10.9 million positron and electron events is presented. This measurement extends the energy range of our previous observation and increases its precision. The new results show, for the first time, that above ∼200 GeV the positron fraction no longer exhibits an increase with energy.

Published
2016
Full Text
View/download PDF

28. System Analysis on the Organization and Management of the Industry of Biomass Solid Densified Fuel for Heating in China

Author

S. Song, J. Xu, S. Lv, M. He, P. Liu, L. Ma, W. Ni, and C. Chong

Subjects
lcsh:Computer engineering. Computer hardware, lcsh:TP155-156, lcsh:TK7885-7895, lcsh:Chemical engineering
Abstract

The problem of industrial organization and management is one of the main challenges for China to realize a rapid development of biomass solid densified fuel (BSDF) for heating following the targets of the 13th Five-Year- Plan. This manuscript developed a framework of system analysis, including the analysis on decision-making, execution, operation, market and information interactions, to identify key barriers existed in the organization and management of this industry and put forwards policy suggestions. The results present that China has already built an integrated organization and management system of this industry, and the key barriers include the contradiction between industry development and air pollution control, the weak economic competitiveness and the huge delay of information and feedback between the top decision-making and executive levels and the bottom engineering system level in the market. The main policy implications are that Chinese governments need to clearly define BSDF as a clean fuel or not, to enhance the financial support of BSDF for heating and to enhance market investigation by decision-making and executive levels.

Published
2017

30. Ambient temperature influence on temperature of MCCB bimetal

Author

M. Zong and S. Lv

Subjects
Materials science, 020209 energy, Hardware_PERFORMANCEANDRELIABILITY, 02 engineering and technology, Temperature measurement, Supply and distribution, Automotive engineering, Bimetal, Hardware_GENERAL, Electrical equipment, Hardware_INTEGRATEDCIRCUITS, 0202 electrical engineering, electronic engineering, information engineering, Fuse (electrical), Low voltage, Circuit breaker
Abstract

Low voltage circuit breaker is the main switch electrical equipment of low voltage power supply and distribution system.

Published
2017
Full Text
View/download PDF

31. Numerical simulation of force characteristics and contact loss of high-speed railway subgrade

Author

S. Lv, Y. X. Lv, H. Xiao, and Y. H. Wang

Subjects
Computer simulation, Geotechnical engineering, Subgrade, Geology
Abstract

In order to explore the dynamic stress distribution, attenuation characteristics of subgrade under high-speed train load, a three-dimensional solid model was established by the ABAQUS finite element software, and the dynamic stress characteristics of subgrade of high-speed railway were calculated and analyzed. The research results show that: The distribution of additional dynamic stress on the surface of subgrade is close to elliptical, and the distribution on the cross section is similar to saddle-shaped; the peak value of stress appears below the rail. The additional dynamic stress of the subgrade has no superposition effect between the front rear bogie and the rear front bogie of the two trains. The additional dynamic stress distribution of the subgrade surface can be regarded as four stress waves that do not overlap each other. When the contact degradation shape of the subgrade gravel and the track structure concrete base is assumed to be rectangular, the aspect ratio is between 2 and 3.3. With the deterioration of the contact state, the maximum additional dynamic stress of the surface layer of the subgrade is 120 kPa.

Published
2020
Full Text
View/download PDF

32. Active CO2 two-phase loops for the AMS-02 tracker

Author

C. C. Yeh, J. F. Cao, X.-H. Sun, G. M. Shue, J. Y. Miao, Serena Borsini, N. S. Xu, A. Pauw, D. C. Mo, E. Laudi, G. Alberti, Z. H. He, M. Menichelli, Chengpei Tang, Z. Zhang, K. H. Guo, W. J. Xiao, Z. L. Weng, J. van Es, Roberto Battiston, A. Lebedev, Jiangqun Ni, T. Zwartbol, Ting-xuen Li, S.C. Lee, D. J. Sun, S. S. Lv, C. Gargiulo, A. Alvino, X. M. Qi, G. Ambrosi, Z. C. Huang, Y. Chen, F. K. Yang, B. Verlaat, L. Guo, V. Koutsenko, Y. L. Lin, Zheng Wang, and M. Bardet

Subjects
Physics, Nuclear physics, Space and Planetary Science, Antimatter, Magnet, International Space Station, Dark matter, Alpha Magnetic Spectrometer, Aerospace Engineering, Particle, Charge (physics), Electrical and Electronic Engineering, Tracking (particle physics)
Abstract

The Alpha Magnetic Spectrometer AMS-02 [1]?[4] is an astro particle physics experiment running on the International Space Station (ISS; see Figure 1) since May 19, 2011. Its missions include the search for antimatter and the identifcation of the nature of dark matter. The AMS silicon tracker is the only subdetector inside the AMS permanent magnet that can detect the charge of a moving particle to distinguish an anti-particle from particle (see Table 1 for nomenclature).

Published
2014
Full Text
View/download PDF

33. OP11.02: Smart‐planes fetal heart automatically generate fetal ventricular outflow tract views and to quantitate fetal aortic and pulmonary artery dimensions

Author

Mei Pan, S. Lv, Bei Wang, B.W. Zhao, Xiaohui Peng, and R. Chen

Subjects
medicine.medical_specialty, Fetus, Radiological and Ultrasound Technology, business.industry, Obstetrics and Gynecology, Fetal heart, General Medicine, Reproductive Medicine, Internal medicine, medicine.artery, Pulmonary artery, medicine, Cardiology, Ventricular outflow tract, Radiology, Nuclear Medicine and imaging, business
Published
2019
Full Text
View/download PDF

34. An experimental and theoretical method for determination of standard electrode potential for the redox couple diphenyl sulfone/diphenyl sulfide

Author

J. S. Lv, K. X. Wei, and Y. Z. Song

Subjects
chemistry.chemical_compound, Chemistry, Diphenyl sulfone, Standard electrode potential, Inorganic chemistry, Electrode, Physical and Theoretical Chemistry, Electrochemistry, Redox, Mulliken population analysis, Equilibrium constant, Flue-gas desulfurization
Abstract

DFT calculations were performed for diphenyl sulfide and diphenyl sulfone. The electrochemistry of diphenyl sulfide on the gold electrode was investigated by cyclic voltammety and the results show that standard electrode potential for redox couple diphenyl sulfone/diphenyl sulfide is 1.058 V, which is consistent with that of 1.057 calculated at B3LYP/6-31++G(d,p)-IEFPCM level. The front orbit theory and Mulliken charges of molecular explain well on the oxidation of diphenyl sulfide in oxidative desulfurization. According to equilibrium theory the experimental equilibrium constant in the oxidative desulfurization of H2O2, is 1.17 × 1048, which is consistent with the theoretical equilibrium constant is 2.18 × 1048 at B3LYP/6-31++G(d,p)-IEFPCM level.

Published
2013
Full Text
View/download PDF

35. The Establishment and Function of Schistosomiasis Surveillance System Towards Elimination in The People's Republic of China

Author

L-J, Zhang, S-Z, Li, L-Y, Wen, D-D, Lin, E M, Abe, R, Zhu, Y, Du, S, Lv, J, Xu, B L, Webster, D, Rollinson, and X-N, Zhou

Subjects
China, Geography, Schistosomiasis japonica, Epidemiological Monitoring, Animals, Humans, Public Health, Disease Eradication, Schistosoma japonicum
Abstract

Schistosoma japonicum is the main schistosome species in The People's Republic of China, causing intestinal schistosomiasis, a debilitating disease of public health importance. The People's Republic of China used to be heavily endemic with schistosomiasis, but great progress has been made through the vigorous efforts of the national control programmes in the last six decades. Presently, efforts are geared towards eliminating schistosomiasis from The People's Republic of China by the end of 2025 through effective schistosomiasis surveillance, an important component in the drive towards schistosomiasis elimination. Therefore, this article explicitly outlines the development and progress made in schistosomiasis surveillance since 1990 with a special focus on the new surveillance system in use. Although the surveillance system has steadily improved over the years, it is faced with many challenges. Hence, more efforts are needed to establish an effective and sensitive evaluation system for the national schistosomiasis elimination programme in The People's Republic of China.

Published
2016

36. Evolution of the National Schistosomiasis Control Programmes in The People's Republic of China

Author

J, Xu, P, Steinman, D, Maybe, X-N, Zhou, S, Lv, S-Z, Li, and R, Peeling

Subjects
Government Programs, China, Zoonoses, Communicable Disease Control, Animals, Humans, Schistosomiasis, History, 20th Century, History, 21st Century
Abstract

Schistosomiasis japonica is caused by the parasitic trematode Schistosoma japonicum. It is endemic in The People's Republic of China and has significant impact on human health and socioeconomic development in certain regions. Over the last six decades, the national control programmes evolved in remarkable ways and brought schistosomiasis japonica largely under control. We describe the history and evolution of schistosomiasis control in The People's Republic of China, with an emphasis on shifts in control strategies that evolved with new insights into the biology of the parasite and its intermediate hosts, and the epidemiology of the disease in the country. We also highlight the achievements in controlling the disease in different socioecological settings, and identify persisting challenges to fully eliminate schistosomiasis japonica from the country. To reach the goal of schistosomiasis elimination, further integration of interventions, multisector collaboration, sensitive and effective surveillance are needed to strengthen.

Published
2016

37. Biology and Control of Snail Intermediate Host of Schistosoma japonicum in The People's Republic of China

Author

Z-J, Li, J, Ge, J-R, Dai, L-Y, Wen, D-D, Lin, H, Madsen, X-N, Zhou, and S, Lv

Subjects
China, Geography, Schistosomiasis japonica, Snails, Animals, Humans, Ecosystem, Schistosoma japonicum, Disease Reservoirs
Abstract

Schistosomiasis caused by Schistosoma japonicum is a severe parasitic disease in The People's Republic of China and imposed considerable burden on human and domestic animal health and socioeconomic development. The significant achievement in schistosomiasis control has been made in last 60years. Oncomelania hupensis as the only intermediate host of S. japonicum plays a key role in disease transmission. The habitat complexity of the snails challenges to effective control. In this review we share the experiences in control and research of O. hupensis.

Published
2016

38. Precision Measurement of the (e^{+}+e^{-}) Flux in Primary Cosmic Rays from 0.5 GeV to 1 TeV with the Alpha Magnetic Spectrometer on the International Space Station

Author

Aguilar, M., Aisa, D., Alpat, B., Alvino, A., Ambrosi, G., Andeen, K., Arruda, L., Attig, N., Azzarello, P., Bachlechner, A., Barao, F., Barrau, A., Barrin, L., Bartoloni, A., Basara, L., Battarbee, M., Battiston, R., Bazo, J., Becker, U., Behlmann, M., Beischer, B., Berdugo, J., Bertucci, B., Bigongiari, Gabriele, Bindi, V., Bizzaglia, S., Bizzarri, M., Boella, G., De Boer, W., Bollweg, K., Bonnivard, V., Borgia, B., Borsini, S., Boschini, M. J., Bourquin, M., Burger, J., Cadoux, F., Cai, X. D., Capell, M., Caroff, S., Casaus, J., Cascioli, V., Castellini, G., Cernuda, I., Cervelli, F., Chae, M. J., Chang, Y. H., Chen, A. I., Chen, H., Cheng, G. M., Chen, H. S., Cheng, L., Chikanian, A., Chou, H. Y., Choumilov, E., Choutko, V., Chung, C. H., Clark, C., Clavero, R., Coignet, G., Consolandi, C., Contin, A., Corti, C., Coste, B., Crispoltoni, M., Cui, Z., Dai, M., Delgado, C., Della Torre, S., Demirköz, M. B., Derome, L., Di Falco, S., Di Masso, L., Dimiccoli, F., Díaz, C., Von Doetinchem, P., Donnini, F., W. J., Du, Duranti, M., D'Urso, D., Eline, A., Eppling, F. J., Eronen, T., Fan, Y. Y., Farnesini, L., Feng, J., Fiandrini, E., Fiasson, A., Finch, E., Fisher, P., Galaktionov, Y., Gallucci, G., García, B., García López, R., Gargiulo, C., Gast, H., Gebauer, I., Gervasi, M., Ghelfi, A., Gillard, W., Giovacchini, F., Goglov, P., Gong, J., Goy, C., Grabski, V., Grandi, D., Graziani, M., Guandalini, C., Guerri, I., Guo, K. H., Habiby, M., Haino, S., Han, K. C., Z. H., He, Heil, M., Hoffman, J., Hsieh, T. H., Huang, Z. C., Huh, C., Incagli, M., Ionica, M., Jang, W. Y., Jinchi, H., Kanishev, K., Kim, G. N., Kim, K. S., Kirn, T. h., Kossakowski, R., Kounina, O., Kounine, A., Koutsenko, V., Krafczyk, M. S., Kunz, S., La Vacca, G., Laudi, E., Laurenti, G., Lazzizzera, I., Lebedev, A., Lee, H. T., Lee, S. C., Leluc, C., H. L., Li, J. Q., Li, Li, Q., T. X., Li, Li, W., Li, Y., Z. H., Li, Z. Y., Li, Lim, S., Lin, C. H., Lipari, P., Lippert, T., Liu, D., Liu, H., Lomtadze, T., M. J., Lu, Y. S., Lu, Luebelsmeyer, K., Luo, F., Luo, J. Z., S. S., Lv, Majka, R., Malinin, A., Mañá, C., Marín, J., Martin, T., Martínez, G., Masi, N., Maurin, D., Menchaca Rocha, A., Meng, Q., D. C., Mo, Morescalchi, L., Mott, P., Müller, M., J. Q., Ni, Nikonov, N., Nozzoli, F., Nunes, P., Obermeier, A., Oliva, A., Orcinha, M., Palmonari, F., Palomares, C., Paniccia, M., Papi, A., Pauluzzi, M., Pedreschi, E., Pensotti, S., Pereira, R., Pilo, F., Piluso, A., Pizzolotto, C., Plyaskin, V., Pohl, M., Poireau, V., Postaci, E., Putze, A., Quadrani, L., X. M., Qi, Räihä, T., Rancoita, P. G., Rapin, D., Ricol, J. S., Rodríguez, I., Rosier Lees, S., Rozhkov, A., Rozza, D., Sagdeev, R., Sandweiss, J., Saouter, P., Sbarra, C., Schael, S., Schmidt, S. M., Schuckardt, D., Schulz Von Dratzig, A., Schwering, G., Scolieri, G., Seo, E. S., Shan, B. S., Shan, Y. H., Shi, J. Y., Shi, X. Y., Shi, Y. M., Siedenburg, T., Son, D., Spada, F., Spinella, F., Sun, W., Sun, W. H., Tacconi, M., Tang, C. P., Tang, X. W., Tang, Z. C., Tao, L., Tescaro, D., Ting, Samuel C. C., Ting, S. M., Tomassetti, N., Torsti, J., Türkoʇlu, C., Urban, T., Vagelli, V., Valente, E., Vannini, C., Valtonen, E., Vaurynovich, S., Vecchi, M., Velasco, M., Vialle, J. P., Wang, L. Q., Wang, Q. L., Wang, R. S., Wang, X., Wang, Z. X., Weng, Z. L., Whitman, K., Wienkenhöver, J., Wu, H., Xia, X., Xie, M., Xie, S., Xiong, R. Q., Xin, G. M., N. S., Xu, Xu, W., Yan, Q., Yang, J., Yang, M., Q. H., Ye, Yi, H., Y. J., Yu, Z. Q., Yu, Zeissler, S., Zhang, J. H., Zhang, M. T., Zhang, X. B., Zhang, Z., Zheng, Z. M., Zhuang, H. L., Zhukov, V., Zichichi, A., Zimmermann, N., Zuccon, P., Zurbach, C., M. Aguilar, D. Aisa, B. Alpat, A. Alvino, G. Ambrosi, K. Andeen, L. Arruda, N. Attig, P. Azzarello, A. Bachlechner, F. Barao, A. Barrau, L. Barrin, A. Bartoloni, L. Basara, M. Battarbee, R. Battiston, J. Bazo, U. Becker, M. Behlmann, B. Beischer, J. Berdugo, B. Bertucci, G. Bigongiari, V. Bindi, S. Bizzaglia, M. Bizzarri, G. Boella, W. de Boer, K. Bollweg, V. Bonnivard, B. Borgia, S. Borsini, M. J. Boschini, M. Bourquin, J. Burger, F. Cadoux, X. D. Cai, M. Capell, S. Caroff, J. Casau, V. Cascioli, G. Castellini, I. Cernuda, F. Cervelli, M. J. Chae, Y. H. Chang, A. I. Chen, H. Chen, G. M. Cheng, H. S. Chen, L. Cheng, A. Chikanian, H. Y. Chou, E. Choumilov, V. Choutko, C. H. Chung, C. Clark, R. Clavero, G. Coignet, C. Consolandi, A. Contin, C. Corti, B. Coste, M. Crispoltoni, Z. Cui, M. Dai, C. Delgado, S. Della Torre, M. B. Demirköz, L. Derome, S. Di Falco, L. Di Masso, F. Dimiccoli, C. Díaz, P. von Doetinchem, F. Donnini, W. J. Du, M. Duranti, D. D’Urso, A. Eline, F. J. Eppling, T. Eronen, Y. Y. Fan, L. Farnesini, J. Feng, E. Fiandrini, A. Fiasson, E. Finch, P. Fisher, Y. Galaktionov, G. Gallucci, B. García, R. García-López, C. Gargiulo, H. Gast, I. Gebauer, M. Gervasi, A. Ghelfi, W. Gillard, F. Giovacchini, P. Goglov, J. Gong, C. Goy, V. Grabski, D. Grandi, M. Graziani, C. Guandalini, I. Guerri, K. H. Guo, M. Habiby, S. Haino, K. C. Han, Z. H. He, M. Heil, J. Hoffman, T. H. Hsieh, Z. C. Huang, C. Huh, M. Incagli, M. Ionica, W. Y. Jang, H. Jinchi, K. Kanishev, G. N. Kim, K. S. Kim, Th. Kirn, R. Kossakowski, O. Kounina, A. Kounine, V. Koutsenko, M. S. Krafczyk, S. Kunz, G. La Vacca, E. Laudi, G. Laurenti, I. Lazzizzera, A. Lebedev, H. T. Lee, S. C. Lee, C. Leluc, H. L. Li, J. Q. Li, Q. Li, T. X. Li, W. Li, Y. Li, Z. H. Li, Z. Y. Li, S. Lim, C. H. Lin, P. Lipari, T. Lippert, D. Liu, H. Liu, T. Lomtadze, M. J. Lu, Y. S. Lu, K. Luebelsmeyer, F. Luo, J. Z. Luo, S. S. Lv, R. Majka, A. Malinin, C. Mañá, J. Marín, T. Martin, G. Martínez, N. Masi, D. Maurin, A. Menchaca-Rocha, Q. Meng, D. C. Mo, L. Morescalchi, P. Mott, M. Müller, J. Q. Ni, N. Nikonov, F. Nozzoli, P. Nune, A. Obermeier, A. Oliva, M. Orcinha, F. Palmonari, C. Palomare, M. Paniccia, A. Papi, M. Pauluzzi, E. Pedreschi, S. Pensotti, R. Pereira, F. Pilo, A. Piluso, C. Pizzolotto, V. Plyaskin, M. Pohl, V. Poireau, E. Postaci, A. Putze, L. Quadrani, X. M. Qi, T. Räihä, P. G. Rancoita, D. Rapin, J. S. Ricol, I. Rodríguez, S. Rosier-Lee, A. Rozhkov, D. Rozza, R. Sagdeev, J. Sandwei, P. Saouter, C. Sbarra, S. Schael, S. M. Schmidt, D. Schuckardt, A. Schulz von Dratzig, G. Schwering, G. Scolieri, E. S. Seo, B. S. Shan, Y. H. Shan, J. Y. Shi, X. Y. Shi, Y. M. Shi, T. Siedenburg, D. Son, F. Spada, F. Spinella, W. Sun, W. H. Sun, M. Tacconi, C. P. Tang, X. W. Tang, Z. C. Tang, L. Tao, D. Tescaro, Samuel C. C. Ting, S. M. Ting, N. Tomassetti, J. Torsti, C. Türkoğlu, T. Urban, V. Vagelli, E. Valente, C. Vannini, E. Valtonen, S. Vaurynovich, M. Vecchi, M. Velasco, J. P. Vialle, L. Q. Wang, Q. L. Wang, R. S. Wang, X. Wang, Z. X. Wang, Z. L. Weng, K. Whitman, J. Wienkenhöver, H. Wu, X. Xia, M. Xie, S. Xie, R. Q. Xiong, G. M. Xin, N. S. Xu, W. Xu, Q. Yan, J. Yang, M. Yang, Q. H. Ye, H. Yi, Y. J. Yu, Z. Q. Yu, S. Zeissler, J. H. Zhang, M. T. Zhang, X. B. Zhang, Z. Zhang, Z. M. Zheng, H. L. Zhuang, V. Zhukov, A. Zichichi, N. Zimmermann, P. Zuccon, C. Zurbach, Aguilar, M, Aisa, D, Alpat, B, Alvino, A, Ambrosi, G, Andeen, K, Arruda, L, Attig, N, Azzarello, P, Bachlechner, A, Barao, F, Barrau, A, Barrin, L, Bartoloni, A, Basara, L, Battarbee, M, Battiston, R, Bazo, J, Becker, U, Behlmann, M, Beischer, B, Berdugo, J, Bertucci, B, Bigongiari, G, Bindi, V, Bizzaglia, S, Bizzarri, M, Boella, G, de Boer, W, Bollweg, K, Bonnivard, V, Borgia, B, Borsini, S, Boschini, M, Bourquin, M, Burger, J, Cadoux, F, Cai, X, Capell, M, Caroff, S, Casaus, J, Cascioli, V, Castellini, G, Cernuda, I, Cervelli, F, Chae, M, Chang, Y, Chen, A, Chen, H, Cheng, G, Cheng, L, Chikanian, A, Chou, H, Choumilov, E, Choutko, V, Chung, C, Clark, C, Clavero, R, Coignet, G, Consolandi, C, Contin, A, Corti, C, Coste, B, Crispoltoni, M, Cui, Z, Dai, M, Delgado, C, Della Torre, S, Demirköz, M, Derome, L, Di Falco, S, Di Masso, L, Dimiccoli, F, Díaz, C, von Doetinchem, P, Donnini, F, Du, W, Duranti, M, D’Urso, D, Eline, A, Eppling, F, Eronen, T, Fan, Y, Farnesini, L, Feng, J, Fiandrini, E, Fiasson, A, Finch, E, Fisher, P, Galaktionov, Y, Gallucci, G, García, B, García López, R, Gargiulo, C, Gast, H, Gebauer, I, Gervasi, M, Ghelfi, A, Gillard, W, Giovacchini, F, Goglov, P, Gong, J, Goy, C, Grabski, V, Grandi, D, Graziani, M, Guandalini, C, Guerri, I, Guo, K, Habiby, M, Haino, S, Han, K, He, Z, Heil, M, Hoffman, J, Hsieh, T, Huang, Z, Huh, C, Incagli, M, Ionica, M, Jang, W, Jinchi, H, Kanishev, K, Kim, G, Kim, K, Kirn, T, Kossakowski, R, Kounina, O, Kounine, A, Koutsenko, V, Krafczyk, M, Kunz, S, LA VACCA, G, Laudi, E, Laurenti, G, Lazzizzera, I, Lebedev, A, Lee, H, Lee, S, Leluc, C, Li, H, Li, J, Li, Q, Li, T, Li, W, Li, Y, Li, Z, Lim, S, Lin, C, Lipari, P, Lippert, T, Liu, D, Liu, H, Lomtadze, T, Lu, M, Lu, Y, Luebelsmeyer, K, Luo, F, Luo, J, Lv, S, Majka, R, Malinin, A, Mañá, C, Marín, J, Martin, T, Martínez, G, Masi, N, Maurin, D, Menchaca Rocha, A, Meng, Q, Mo, D, Morescalchi, L, Mott, P, Müller, M, Ni, J, Nikonov, N, Nozzoli, F, Nunes, P, Obermeier, A, Oliva, A, Orcinha, M, Palmonari, F, Palomares, C, Paniccia, M, Papi, A, Pauluzzi, M, Pedreschi, E, Pensotti, S, Pereira, R, Pilo, F, Piluso, A, Pizzolotto, C, Plyaskin, V, Pohl, M, Poireau, V, Postaci, E, Putze, A, Quadrani, L, Qi, X, Räihä, T, Rancoita, P, Rapin, D, Ricol, J, Rodríguez, I, Rosier Lees, S, Rozhkov, A, Rozza, D, Sagdeev, R, Sandweiss, J, Saouter, P, Sbarra, C, Schael, S, Schmidt, S, Schuckardt, D, Schulz von Dratzig, A, Schwering, G, Scolieri, G, Seo, E, Shan, B, Shan, Y, Shi, J, Shi, X, Shi, Y, Siedenburg, T, Son, D, Spada, F, Spinella, F, Sun, W, Tacconi, M, Tang, C, Tang, X, Tang, Z, Tao, L, Tescaro, D, Ting, S, Tomassetti, N, Torsti, J, Türkoğlu, C, Urban, T, Vagelli, V, Valente, E, Vannini, C, Valtonen, E, Vaurynovich, S, Vecchi, M, Velasco, M, Vialle, J, Wang, L, Wang, Q, Wang, R, Wang, X, Wang, Z, Weng, Z, Whitman, K, Wienkenhöver, J, Wu, H, Xia, X, Xie, M, Xie, S, Xiong, R, Xin, G, Xu, N, Xu, W, Yan, Q, Yang, J, Yang, M, Ye, Q, Yi, H, Yu, Y, Yu, Z, Zeissler, S, Zhang, J, Zhang, M, Zhang, X, Zhang, Z, Zheng, Z, Zhuang, H, Zhukov, V, Zichichi, A, Zimmermann, N, Zuccon, P, Zurbach, C, Azzarello, Philipp, Bourquin, Maurice, Cadoux, Franck, Habiby Alaoui, Marion, Leluc, Catherine, Li, Yang, Paniccia, Mercedes, Pohl, Martin, Rapin, Divic Jean, and Saouter, Pierre

Subjects
electron, Astrophysics and Astronomy, Astrophysics::High Energy Astrophysical Phenomena, Electrons, ddc:500.2, COSMIC RAYS, AMS, Cosmic Rays, electrons, Space mission, Physics and Astronomy (all), FIS/05 - ASTRONOMIA E ASTROFISICA, Positrons, FIS/01 - FISICA SPERIMENTALE, positron, High Energy Physics::Experiment, AMS, Nuclear Experiment, Particle Physics - Experiment
Abstract

We present a measurement of the cosmic ray (e^+ + e^-) flux in the range 0.5 GeV to 1 TeV based on the analysis of 10.6 million (e^+ + e^-) events collected by AMS. The statistics and the resolution of AMS provide a precision measurement of the flux. The flux is smooth and reveals new and distinct information. Above 30.2 GeV, the flux can be described by a single power law with a spectral index γ = −3.170 +/- 0.008 (stat + syst) +/- 0.008 (energy scale)

Published
2014
Full Text
View/download PDF

39. Electrochemical reduction of tartrazine at multi-walled carbon nanotube-modified pyrolytic graphite electrode

Author

J. S. Lv, Yong Ye, J. M. Xie, J. M. Xu, H. Zhong, and Y. Z. Song

Subjects
Detection limit, Reproducibility, Inorganic chemistry, chemistry.chemical_element, Carbon nanotube, Electrochemistry, law.invention, chemistry.chemical_compound, chemistry, law, Electrode, Pyrolytic carbon, Physical and Theoretical Chemistry, Carbon, Tartrazine
Abstract

Electrochemical reduction of tartrazine on multi-walled carbon nanotube-modied pyrolytic graphite electrode is investigated. A simple, sensitive and inexpensive method for determination of tartrazine in drinks is proposed. The accuracy and reproducibility of the determination method for various known amounts of tartrazine were evaluated. This method was satisfactorily applied for the determination of tartrazine in drinks. The reduction peak currents were proportional to tartrazine concentrations over two intervals in the range from 2.0 to 70.0 mg l−1 and from 70.0 to 230.0 mg l−1, and the detection limit for tartrazine is 0.5 mg l−1.

Published
2012
Full Text
View/download PDF

40. Optimization of Plastic Injection Molding Process Parameters for Thin-Wall Plastics Injection Molding

Author

Hou-Yong Yu, S. Lv, and Jie Jin

Subjects
chemistry.chemical_classification, Thermoplastic, Materials science, General Engineering, Process (computing), Molding (process), Factorial experiment, medicine.disease_cause, Taguchi methods, chemistry, Mold, medicine, Orthogonal array, Composite material, Shrinkage
Abstract

The effects of the process parameters on the warpge and shrinkage of parts in different thickness are analyzed by Taguchi optimization method. Taguchi optimization method was used for exploiting mold analysis based on three level factorial designs. Orthogonal arrays of Taguchi, the signal-to-noise (S/N) ratio, the analysis of variance (ANOVA) are utilized to find the optimal levels and the effect of process parameters on warpage. It can be concluded that Taguchi method is suitable to solve the quality problem of the injection-molded thermoplastic parts.

Published
2009
Full Text
View/download PDF

43. A recombined fusion protein SP5.2/tTF induce thrombosis in tumor blood vessel

Author

S Lv, X Luo, M Ye, X Li, F Zeng, L Luo, J Yan, Y Dai, X Chen, C Wang, X Wang, K Li, Z Li, and X Dou

Subjects
endocrine system, Cancer Research, Expression vector, respiratory system, Fusion protein, Molecular biology, Umbilical vein, law.invention, Fusion gene, chemistry.chemical_compound, Tissue factor, Oncology, chemistry, law, Recombinant DNA, Growth inhibition, Chromatography column
Abstract

Tumor vascular targeting is one of the most promising strategies in tumor therapy. Here we used E.coli to express a recombinant SP5.2/tTF fusion protein, which, as a tumor vascular targeting agent, consists of SP5.2 (a peptide selectively binding and targeting VEGFR-1 on tumor endothelial cells) and truncated tissue factor (tTF)and aimed to explore its anti-tumor activities.The SP5.2/tTF expression construct was synthesized by polymerase chain reaction (PCR) and recombined into plasmid pET22b(+). The fusion gene was verified by restriction mapping and sequencing. SP5.2/tTF was expressed in E. coli and then purified on a nickel-affinity chromatography column. The purified product was detected by SDS-PAGE. The pro-coagulant activity and binding of SP5.2/tTF to human umbilical vein endothelial cells (HUVECs) were monitored by FX activation analysis and fluorescent scanning confocal microscopy, respectively. The effect of SP5.2/tTF on tumor growth was analyzed in BALB/c mice bearing sarcoma 180 (S180) tumor. The tissue localization of SP5.2/tTF and its effect on tumor vessel thrombosis were observed by in vivo fluorescence imaging and histological studies, respectively. The fusion gene was successfully cloned into pET22b(+). SP5.2/tTF was abundantly expressed in bacterial cells and efficiently purified by nickel-affinity chromatography. Functional studies showed that the protein retained both the coagulation activity of tTF and the binding capacity of SP5.2 to HUVECs. In tumor xenograft studies, SP5.2/tTF selectively targeted the tumor, induced thrombosis, and led to retardation and even regression of tumor growth (growth inhibition ratio = 70%, P< 0.05). The recombinant fusion protein SP5.2/tTF inhibited tumor growth by selectively inducing thrombosis in tumor blood vessels.

Published
2015

44. Application of manganese dioxide to electromagnetic wave absorber: effective permittivity and absorbing property

Author

S. Lv, Y. Zhao, Hongtao Guan, and S. Liu

Subjects
Permittivity, Materials science, Mixing (process engineering), Mineralogy, chemistry.chemical_element, Manganese, Dielectric, Condensed Matter Physics, Electromagnetic radiation, Electronic, Optical and Magnetic Materials, Condensed Matter::Materials Science, symbols.namesake, Volume (thermodynamics), chemistry, symbols, Condensed Matter::Strongly Correlated Electrons, Composite material, Rayleigh scattering, Instrumentation, High-κ dielectric
Abstract

This paper presents the application of manganese dioxide to electromagnetic wave absorber. The effective permittivity was calculated by modified Rayleigh mixing formula, and the electromagnetic wave absorbing properties of composites with different volume fractions of manganese dioxide were investigated by the comparison of calculated and experimental values in 2–12 GHz frequencies. It is found that the pure manganese dioxide holds a high dielectric constant, which is a function of frequency. The manganese dioxide composites show high absorbing performance in low frequencies, and the calculated electromagnetic properties fit the experimental values for large volume fractions used in this study.

Published
2006
Full Text
View/download PDF

47. Precision Measurement of the Helium Flux in Primary Cosmic Rays of Rigidities 1.9 GV to 3 TV with the Alpha Magnetic Spectrometer on the International Space Station

Author

N. Nikonov, Corrado Gargiulo, A. Egorov, I. Cernuda, Carlos Díaz, W. De Boer, Corinne Goy, Wei Sun, Haifeng Li, P. Vialle, E. Fiandrini, H. S. Chen, Zhiqi Huang, Xiaoqun Wang, I. Gebauer, C. Türkoğlu, Arturo Alejandro Menchaca-Rocha, S. Krafczyk, L. Tao, S. Xie, J. Q. Ni, Fabrizio Giulio Luca Pilo, F. Spinella, S. S. Lv, Maria Ionica, S. Chen, Markus Battarbee, J. Gong, J. Sandweiss, H. Y. Chou, R. D. Majka, S. Wang, Z. Q. Yu, O. Kounina, Paolo Zuccon, Samuel C.C. Ting, H. Yi, H. Wu, Z. Cui, W. Tang, H. Shan, M. Qi, Matthias Heil, E. Finch, J. H. Zhang, S. Zhang, W. Creus, G. Laurenti, T. J. N. Nelson, E. Valente, M. Paniccia, A. Von Dratzig, Davide Rozza, K. Andeen, L. Farnesini, I. Rodríguez, Chuanguo Zhang, Z. L. Weng, D. Rapin, V. Plyaskin, A. Lebedev, A. Papi, Dong-Chul Son, P. Tang, J. W. Song, J. Wienkenhöver, Andrea Contin, Hengchang Liu, S. Lim, H. Sun, Philipp Azzarello, N. Masi, F. Luo, L. Barrin, Z. Qu, M. Willenbrock, J. J. Torsti, S. Pensotti, G. La Vacca, Mauro Tacconi, Roald Z. Sagdeev, Yang Yang, G. Schwering, Antonino Zichichi, G. Coignet, David Maurin, Xin Wu, J. Eppling, S. Della Torre, M. Crispoltoni, S. Rosier-Lees, J. Casaus, L. Qu, Chung-Cherng Lin, Teimuraz Lomtadze, M. B. Demirköz, C. Han, Henning Gast, M. Aguilar, Matteo Boschini, Chau-Hwang Lee, J. Berdugo, A. Fiasson, F. Dimiccoli, Wei Li, Laurent Derome, A. Bartoloni, X. Xia, C. Pizzolotto, R. J. García-López, Y. Fan, E. Choumilov, J. C. Marin, V. Poireau, Xubo Qin, P. Mott, Yun Shi, R. Kossakowski, Franck Cadoux, P. Nunes, A. Rozhkov, F. Spada, Lin Cheng, N. Picot-Clemente, F. Palmonari, M. Bourquin, C. Ting, L. Di Masso, M. Bizzarri, M. Duranti, E. Pedreschi, L. Basara, U. Becker, C. H. Chung, Xinxin Li, Y. J. Yu, S. Zeissler, Yu. Galaktionov, D. Aisa, I. Guerri, G. Boella, Varlen Grabski, M. Vecchi, Massimo Gervasi, Dong Liu, Z. Luo, Thomas Lippert, S. Q. Lu, Mayda Velasco, Valery Zhukov, M. T. Zhang, S. Vitillo, Z. M. Zheng, Fernando Barão, M. Pauluzzi, Bruce Rafael Mellado Garcia, Z. H. He, A. I. Chen, V. Vitale, F. Nozzoli, H. Jinchi, M. Behlmann, T. Siedenburg, A. Piluso, D. Cerreta, A. Ghelfi, M. Capell, Claudio Corti, Ningsheng Xu, G. Ambrosi, S. Caroff, J. Hoffman, T. Eronen, R. Clavero, D. Grandi, W. Xu, Naihua Wang, F. Cervelli, A. Obermeier, E. Gil, P. Lipari, T. Räihä, P. Goglov, I. Lazzizzera, M. Pohl, B. Bertucci, M. Xie, H. Ye, C. Mañá, Veronica Bindi, G. Scolieri, Nicola Tomassetti, Shihao Zhang, Hsiang Szu Chang, Behcet Alpat, Luísa Arruda, Antje Putze, T. Kirn, D. Haas, V. Vagelli, Shinhong Kim, C. Mo, Pier-Giorgio Rancoita, Q. Meng, Sadakazu Haino, H. L. Zhuang, A. Barrau, S. J. Schmidt, Q. L. Wang, C. Delgado, T. Urban, V. Choutko, A. Korkmaz, S. Seo, M. J. Chae, C. Guandalini, R. Pereira, M. Chen, K. Bollweg, Miaoran Lu, Zheng Wang, M. Habiby, B. Coste, M. Graziani, V. Formato, Horngming Hsieh, M. Incagli, K. Whitman, Ju Li, Roberto Battiston, B. Borgia, J. Yang, H. Guo, M. Müller, Changgi Huh, Zhijun Zhang, P. Saouter, S. Di Falco, Peter H. Fisher, Tim Martin, F. Giovacchini, Luca Morescalchi, Q. Xiong, K. Luebelsmeyer, Zhixiang Tang, M. Orcinha, A. Alvino, C. Vannini, S. Shan, P. von Doetinchem, N. Kim, X. D. Cai, F. Donnini, N. Attig, Hyun Lee, Andrei Kounine, Q. Yan, N. Zimmermann, S. Borsini, G. Castellini, J. Feng, G. Martinez, C. Palomares, C. Clark, S. Schael, C. Consolandi, Elisa Laudi, J. D. Burger, S. S. Vaurynovich, D. Tescaro, Yongyao Li, Mingming Yang, A. Oliva, D. D'Urso, C. Leluc, G. Gallucci, Yaomin Dai, B. Beischer, V. Bonnivard, K. Kanishev, S. Bizzaglia, Y. Jang, A. Bachlechner, X. B. Zhang, J. Bazo, V. Koutsenko, Eino Valtonen, Z. H. Li, Qiang Li, S. Ricol, M. Lolli, A. Eline, Massachusetts Institute of Technology. Department of Physics, Massachusetts Institute of Technology. Laboratory for Nuclear Science, Becker, Ulrich J., Behlmann, Matthew Daniel, Burger, Joseph D., Cai, Xudong, Capell, Michael H., Chen, Andrew I., Chen, H., Choumilov, Evgueni, Choutko, Vitali, Egorov, Alexander, Eline, Alexandre, Eppling, Frederic J., Fisher, Peter H., Galaktionov, Y., Goglov, Pavel, Heil, Melanie, Hsieh, Tsai-hsiu, Kounina, Olga, Kounine, Andrei, Koutsenko, Vladimir, Krafczyk, Matthew Scott, Lebedev, Alexei, Li, J. Q., Li, Q., Plyaskin, Vasily, Rozhkov, Andrey B., Shi, X. Y., Sun, Wei, Sun, W. H., Ting, Samuel, Ting, Susan Marks, Vaurynovich, Siarhei S., Wang, Xiaozhen, Weng, Zhili, Willenbrock, Manfred, Xie, M., Xu, Weiwei, Yan, Q., Zhang, S. D., Zuccon, Paolo, Azzarello, Philipp, Bourquin, Maurice, Cadoux, Franck, Cortina Gil, Eduardo, Haas, Daniel, Habiby Alaoui, Marion, Leluc, Catherine, Li, Yang, Paniccia, Mercedes, Pohl, Martin, Rapin, Divic Jean, Saouter, Pierre, Vitillo, Stefania, Wu, Xin, Aguilar, M, Aisa, D, Alpat, B, Alvino, A, Ambrosi, G, Andeen, K, Arruda, L, Attig, N, Azzarello, P, Bachlechner, A, Barao, F, Barrau, A, Barrin, L, Bartoloni, A, Basara, L, Battarbee, M, Battiston, R, Bazo, J, Becker, U, Behlmann, M, Beischer, B, Berdugo, J, Bertucci, B, Bindi, V, Bizzaglia, S, Bizzarri, M, Boella, G, de Boer, W, Bollweg, K, Bonnivard, V, Borgia, B, Borsini, S, Boschini, M, Bourquin, M, Burger, J, Cadoux, F, Cai, X, Capell, M, Caroff, S, Casaus, J, Castellini, G, Cernuda, I, Cerreta, D, Cervelli, F, Chae, M, Chang, Y, Chen, A, Chen, G, Chen, H, Cheng, L, Chou, H, Choumilov, E, Choutko, V, Chung, C, Clark, C, Clavero, R, Coignet, G, Consolandi, C, Contin, A, Corti, C, Gil, E, Coste, B, Creus, W, Crispoltoni, M, Cui, Z, Dai, Y, Delgado, C, Della Torre, S, Demirköz, M, Derome, L, Di Falco, S, Di Masso, L, Dimiccoli, F, Díaz, C, von Doetinchem, P, Donnini, F, Duranti, M, D’Urso, D, Egorov, A, Eline, A, Eppling, F, Eronen, T, Fan, Y, Farnesini, L, Feng, J, Fiandrini, E, Fiasson, A, Finch, E, Fisher, P, Formato, V, Galaktionov, Y, Gallucci, G, García, B, García López, R, Gargiulo, C, Gast, H, Gebauer, I, Gervasi, M, Ghelfi, A, Giovacchini, F, Goglov, P, Gong, J, Goy, C, Grabski, V, Grandi, D, Graziani, M, Guandalini, C, Guerri, I, Guo, K, Haas, D, Habiby, M, Haino, S, Han, K, He, Z, Heil, M, Hoffman, J, Hsieh, T, Huang, Z, Huh, C, Incagli, M, Ionica, M, Jang, W, Jinchi, H, Kanishev, K, Kim, G, Kim, K, Kirn, T, Korkmaz, M, Kossakowski, R, Kounina, O, Kounine, A, Koutsenko, V, Krafczyk, M, LA VACCA, G, Laudi, E, Laurenti, G, Lazzizzera, I, Lebedev, A, Lee, H, Lee, S, Leluc, C, Li, H, Li, J, Li, Q, Li, T, Li, W, Li, Y, Li, Z, Lim, S, Lin, C, Lipari, P, Lippert, T, Liu, D, Liu, H, Lolli, M, Lomtadze, T, Lu, M, Lu, S, Lu, Y, Luebelsmeyer, K, Luo, F, Luo, J, Lv, S, Majka, R, Mañá, C, Marín, J, Martin, T, Martínez, G, Masi, N, Maurin, D, Menchaca Rocha, A, Meng, Q, Mo, D, Morescalchi, L, Mott, P, Müller, M, Nelson, T, Ni, J, Nikonov, N, Nozzoli, F, Nunes, P, Obermeier, A, Oliva, A, Orcinha, M, Palmonari, F, Palomares, C, Paniccia, M, Papi, A, Pauluzzi, M, Pedreschi, E, Pensotti, S, Pereira, R, Picot Clemente, N, Pilo, F, Piluso, A, Pizzolotto, C, Plyaskin, V, Pohl, M, Poireau, V, Putze, A, Quadrani, L, Qi, X, Qin, X, Qu, Z, Räihä, T, Rancoita, P, Rapin, D, Ricol, J, Rodríguez, I, Rosier Lees, S, Rozhkov, A, Rozza, D, Sagdeev, R, Sandweiss, J, Saouter, P, Schael, S, Schmidt, S, von Dratzig, A, Schwering, G, Scolieri, G, Seo, E, Shan, B, Shan, Y, Shi, J, Shi, X, Shi, Y, Siedenburg, T, Son, D, Song, J, Spada, F, Spinella, F, Sun, W, Tacconi, M, Tang, C, Tang, X, Tang, Z, Tao, L, Tescaro, D, Ting, S, Tomassetti, N, Torsti, J, Türkoğlu, C, Urban, T, Vagelli, V, Valente, E, Vannini, C, Valtonen, E, Vaurynovich, S, Vecchi, M, Velasco, M, Vialle, J, Vitale, V, Vitillo, S, Wang, L, Wang, N, Wang, Q, Wang, R, Wang, X, Wang, Z, Weng, Z, Whitman, K, Wienkenhöver, J, Willenbrock, M, Wu, H, Wu, X, Xia, X, Xie, M, Xie, S, Xiong, R, Xu, N, Xu, W, Yan, Q, Yang, J, Yang, M, Yang, Y, Ye, Q, Yi, H, Yu, Y, Yu, Z, Zeissler, S, Zhang, C, Zhang, J, Zhang, M, Zhang, S, Zhang, X, Zhang, Z, Zheng, Z, Zhuang, H, Zhukov, V, Zichichi, A, Zimmermann, N, Zuccon, P, Aguilar, M., Aisa, D., Alpat, B., Alvino, A., Ambrosi, G., Andeen, K., Arruda, L., Attig, N., Azzarello, P., Bachlechner, A., Barao, F., Barrau, A., Barrin, L., Bartoloni, A., Basara, L., Battarbee, M., Battiston, R., Bazo, J., Becker, U., Behlmann, M., Beischer, B., Berdugo, J., Bertucci, B., Bindi, V., Bizzaglia, S., Bizzarri, M., Boella, G., de Boer, W., Bollweg, K., Bonnivard, V., Borgia, B., Borsini, S., Boschini, M. j., Bourquin, M., Burger, J., Cadoux, F., Cai, X. d., Capell, M., Caroff, S., Casaus, J., Castellini, G., Cernuda, I., Cerreta, D., Cervelli, F., Chae, M. j., Chang, Y. h., Chen, A. i., Chen, G. m., Chen, H. s., Cheng, L., Chou, H. y., Choumilov, E., Choutko, V., Chung, C. h., Clark, C., Clavero, R., Coignet, G., Consolandi, C., Contin, A., Corti, C., Gil, E. Cortina, Coste, B., Creus, W., Crispoltoni, M., Cui, Z., Dai, Y. m., Delgado, C., Della Torre, S., Demirköz, M. b., Derome, L., Di Falco, S., Di Masso, L., Dimiccoli, F., Díaz, C., von Doetinchem, P., Donnini, F., Duranti, M., D’Urso, D., Egorov, A., Eline, A., Eppling, F. j., Eronen, T., Fan, Y. y., Farnesini, L., Feng, J., Fiandrini, E., Fiasson, A., Finch, E., Fisher, P., Formato, V., Gallucci, G., García, B., García-López, R., Gargiulo, C., Gast, H., Gebauer, I., Gervasi, M., Ghelfi, A., Giovacchini, F., Goglov, P., Gong, J., Goy, C., Grabski, V., Grandi, D., Graziani, M., Guandalini, C., Guerri, I., Guo, K. h., Haas, D., Habiby, M., Haino, S., Han, K. c., He, Z. h., Heil, M., Hoffman, J., Hsieh, T. h., Huang, Z. c., Huh, C., Incagli, M., Ionica, M., Jang, W. y., Jinchi, H., Kanishev, K., Kim, G. n., Kim, K. s., Kirn, Th., Korkmaz, M. a., Kossakowski, R., Kounina, O., Kounine, A., Koutsenko, V., Krafczyk, M. s., La Vacca, G., Laudi, E., Laurenti, G., Lazzizzera, I., Lebedev, A., Lee, H. t., Lee, S. c., Leluc, C., Li, H. l., Li, J. q., Li, T. x., Li, W., Li, Y., Li, Z. h., Li, Z. y., Lim, S., Lin, C. h., Lipari, P., Lippert, T., Liu, D., Liu, H., Liu, Hu, Lolli, M., Lomtadze, T., Lu, M. j., Lu, S. q., Lu, Y. s., Luebelsmeyer, K., Luo, F., Luo, J. z., Lv, S. s., Majka, R., Mañá, C., Marín, J., Martin, T., Martínez, G., Masi, N., Maurin, D., Menchaca-Rocha, A., Meng, Q., Mo, D. c., Morescalchi, L., Mott, P., Müller, M., Nelson, T., Ni, J. q., Nikonov, N., Nozzoli, F., Nunes, P., Obermeier, A., Oliva, A., Orcinha, M., Palmonari, F., Palomares, C., Paniccia, M., Papi, A., Pauluzzi, M., Pedreschi, E., Pensotti, S., Pereira, R., Picot-Clemente, N., Pilo, F., Piluso, A., Pizzolotto, C., Plyaskin, V., Pohl, M., Poireau, V., Putze, A., Quadrani, L., Qi, X. m., Qin, X., Qu, Z. y., Räihä, T., Rancoita, P. g., Rapin, D., Ricol, J. s., Rodríguez, I., Rosier-Lees, S., Rozhkov, A., Rozza, D., Sagdeev, R., Sandweiss, J., Saouter, P., Schael, S., Schmidt, S. m., von Dratzig, A. Schulz, Schwering, G., Scolieri, G., Seo, E. s., Shan, B. s., Shan, Y. h., Shi, J. y., Shi, X. y., Shi, Y. m., Siedenburg, T., Son, D., Song, J. w., Spada, F., Spinella, F., Sun, W., Sun, W. h., Tacconi, M., Tang, C. p., Tang, X. w., Tang, Z. c., Tao, L., Tescaro, D., Ting, Samuel C. C., Ting, S. m., Tomassetti, N., Torsti, J., Türkoğlu, C., Urban, T., Vagelli, V., Valente, E., Vannini, C., Valtonen, E., Vaurynovich, S., Vecchi, M., Velasco, M., Vialle, J. p., Vitale, V., Vitillo, S., Wang, L. q., Wang, N. h., Wang, Q. l., Wang, R. s., Wang, X., Wang, Z. x., Weng, Z. l., Whitman, K., Wienkenhöver, J., Willenbrock, M., Wu, H., Wu, X., Xia, X., Xie, S., Xiong, R. q., Xu, N. s., Xu, W., Yang, J., Yang, M., Yang, Y., Ye, Q. h., Yi, H., Yu, Y. j., Yu, Z. q., Zeissler, S., Zhang, C., Zhang, J. h., Zhang, M. t., Zhang, S. d., Zhang, S. w., Zhang, X. b., Zhang, Z., Zheng, Z. m., Zhuang, H. l., Zhukov, V., Zichichi, A., Zimmermann, N., Zuccon, P., UCL - SST/IRMP - Institut de recherche en mathématique et physique, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), and AMS Collaboration

Subjects
Astrophysics and Astronomy, Astrophysics::High Energy Astrophysical Phenomena, General Physics and Astronomy, chemistry.chemical_element, Cosmic ray, Astrophysics, ddc:500.2, Power law, Helium, Space missions, [PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], FIS/05 - ASTRONOMIA E ASTROFISICA, Physics and Astronomy (all), Rigidity (electromagnetism), International Space Station, Alpha Magnetic Spectrometer, ddc:550, AMS, Helium Flux, Primary Cosmic Rays, Cosmic rays, Physics, Spectral index, ta114, Cosmic Rays, Cosmic Helium, Spectral density, ASTROFÍSICA, Computational physics, FIS/01 - FISICA SPERIMENTALE, chemistry, Cosmic ray measurement, Cosmology, Rigidity, Space stations, Spectrometers
Abstract

Physical review letters 115(21), 211101 (2015). doi:10.1103/PhysRevLett.115.211101, Published by APS, College Park, Md.

Published
2015
Full Text
View/download PDF

48. Precision Measurement of the(e++e−)Flux in Primary Cosmic Rays from 0.5 GeV to 1 TeV with the Alpha Magnetic Spectrometer on the International Space Station

Author

Y. Y. Fan, Massimo Gervasi, A. Fiasson, Roberto Battiston, N. Masi, F. Luo, L. Tao, L. Barrin, M. Capell, M. Paniccia, A. Schulz von Dratzig, M. Pohl, B. Borgia, C. Leluc, G. Gallucci, S. S. Vaurynovich, Julio C. Marín, Miaoran Lu, Yongyao Li, G. Boella, K. C. Han, J. Z. Luo, F. Giovacchini, Yun Shi, Q. L. Wang, Luca Morescalchi, Lucio Quadrani, Samuel C.C. Ting, Tim Martin, B. Beischer, V. Bonnivard, C. Delgado, G. Scolieri, Mingming Yang, M. Habiby, A. Malinin, Zhixiang Tang, C. P. Tang, D. C. Mo, A. Eline, J. Y. Shi, M. Müller, Maria Ionica, G. Schwering, J. S. Ricol, Lin Cheng, W. De Boer, K. H. Guo, Dong-Chul Son, S. Schael, X. W. Tang, P. Saouter, Teimuraz Lomtadze, M. Duranti, Yu. Galaktionov, R. J. García-López, N. Nikonov, Liqiu Wang, D. D'Urso, Elisa Laudi, J. Hoffman, I. Guerri, S. M. Schmidt, M. J. Chae, C. Guandalini, K. Luebelsmeyer, Y. J. Yu, H. T. Lee, J. Q. Ni, G. Martinez, C. Palomares, C. Clark, V. Poireau, H. Jinchi, D. Aisa, N. Attig, A. Alvino, J. P. Vialle, L. Basara, Z. M. Zheng, S. Kunz, J. Casaus, Z. Q. Yu, K. Bollweg, A.I. Oliva, A. Ghelfi, Valerio Vagelli, E. Choumilov, X. M. Qi, A. Piluso, D. Rozza, S. Borsini, I. Cernuda, G. Castellini, Jinglai Li, V. Choutko, G. Ambrosi, F. Cervelli, S. Lim, Bruna Bertucci, D. Grandi, T. Urban, R. Kossakowski, Carlos Díaz, S. Bizzaglia, M. J. Boschini, L. Di Masso, I. Gebauer, B. Coste, V. Cascioli, Fabrizio Giulio Luca Pilo, M. Orcinha, D. Tescaro, Timothy H. Hsieh, Manuela Vecchi, W. H. Sun, W. Y. Jang, P. Lipari, T. Räihä, M. Aguilar, Ruiguang Wang, C. Pizzolotto, M. Bizzarri, E. Fiandrini, Y. H. Shan, A. Bartoloni, G. N. Kim, Zhihua Zhang, C. Vannini, Haifeng Li, K. Kanishev, Nicola Tomassetti, H. L. Zhuang, L. Farnesini, M. Graziani, F. Spinella, X. Y. Shi, Z. L. Weng, Chia-Hui Lin, D. Rapin, H. S. Chen, V. Plyaskin, J. Yang, J. Gong, S. Xie, C. Goy, Behcet Alpat, E. Postaci, C. Sbarra, A. Barrau, G. M. Cheng, P. von Doetinchem, Roald Z. Sagdeev, X. D. Cai, Mauro Tacconi, G. Coignet, Antje Putze, Jianfeng Feng, B. S. Shan, Won Kyu Calvin Sun, Q. H. Ye, M. B. Demirköz, H. Yi, Wei Li, K. Whitman, H. Y. Chou, S. Della Torre, Q. Meng, R. D. Majka, F. Donnini, Changgi Huh, X. Xia, J. Wienkenhöver, Z. Cui, Hengchang Liu, E. Pedreschi, W. J. Du, Kwangsoo Kim, Andrei Kounine, Sadakazu Haino, Q. Yan, F. Spada, A. Papi, G. Bigongiari, S. Caroff, Bruce Rafael Mellado Garcia, Paolo Zuccon, Y. H. Chang, R. Clavero, N. Zimmermann, J. J. Torsti, S. Pensotti, Zhao Wang, Antonino Zichichi, Henning Gast, I. Rodríguez, J. Berdugo, Luísa Arruda, A. Rozhkov, S. Zeissler, A. Obermeier, S. Di Falco, Valery Zhukov, C. Consolandi, T. X. Li, Varlen Grabski, P. Mott, M. Incagli, M. Pauluzzi, J. D. Burger, T. Siedenburg, Claudio Corti, M. Bourquin, J. Bazo, R. Q. Xiong, Mayda Velasco, Corrado Gargiulo, P. Azzarello, Zhiqi Huang, S. C. Lee, S. S. Lv, J. Sandweiss, A. Chikanian, Z. Y. Li, A. Bachlechner, X. B. Zhang, Eun-Suk Seo, X. Q. Wang, Ying Lu, S. Rosier-Lees, V. Koutsenko, Eino Valtonen, Z. H. Li, Qiang Li, W. Gillard, C. H. Chung, G. La Vacca, David Maurin, Rui Miguel Faisca Rodrigues Pereira, M. T. Zhang, M. Crispoltoni, M. Behlmann, Laurent Derome, Ningsheng Xu, Franck Cadoux, P. Nunes, D. Liu, D. Schuckardt, Matthias Heil, G. Laurenti, A. I. Chen, P. Goglov, Alexandre Lebedev, P. G. Rancoita, M. S. Krafczyk, I. Lazzizzera, M. Xie, C. Mañá, Veronica Bindi, Z. H. He, F. Nozzoli, C. Zurbach, T. Eronen, W. Xu, T. Kirn, C. Türkoğlu, Arturo Alejandro Menchaca-Rocha, Gongming Xin, Markus Battarbee, E. Finch, J. H. Zhang, K. Andeen, F. Barao, U. Becker, Thomas Lippert, F. J. Eppling, P. H. Fisher, S. M. Ting, F. Palmonari, M. Dai, O. Kounina, H. Wu, Andrea Contin, F. Dimiccoli, and E. Valente

Subjects
Nuclear physics, Physics, Primary (astronomy), International Space Station, Hardware_INTEGRATEDCIRCUITS, Alpha Magnetic Spectrometer, General Physics and Astronomy, Flux, Cosmic ray, Hardware_PERFORMANCEANDRELIABILITY, Hardware_REGISTER-TRANSFER-LEVELIMPLEMENTATION, Hardware_LOGICDESIGN
Published
2014
Full Text
View/download PDF

50. miR-146a inhibits cell growth, cell migration and induces apoptosis in non-small cell lung cancer cells

Author

S. Lv, Peter Kronenberger, Erik Teugels, Jan Sadones, Karel Fostier, Gang Chen, Caroline Geers, Ijeoma Adaku Umelo, Jacques De Greve, Alex Dewaele, Laboratory for Medical and Molecular Oncology, Internal Medicine Specializations, Laboratory of Molecullar and Cellular Therapy, Immunology and Microbiology, Supporting clinical sciences, and Pathology

Subjects
Male, Lung Neoplasms, cervical cancer, Afatinib, Cancer Treatment, Cetuximab, Apoptosis, Pharmacology, Lung and Intrathoracic Tumors, Cell Movement, Carcinoma, Non-Small-Cell Lung, Molecular Cell Biology, Basic Cancer Research, Pathology, Lung, Aged, 80 and over, Multidisciplinary, Cell Death, Cancer Risk Factors, NF-kappa B, Gene Therapy, Middle Aged, Signaling in Selected Disciplines, ErbB Receptors, Gene Expression Regulation, Neoplastic, Cell Motility, Oncology, Monoclonal, Medicine, Female, Erlotinib, medicine.drug, Signal Transduction, Research Article, Adult, Science, Biophysics, Antineoplastic Agents, Biology, Antibodies, Monoclonal, Humanized, Cell Growth, Predisposing Conditions and Syndromes, Gefitinib, Diagnostic Medicine, Cell Line, Tumor, microRNA, medicine, Humans, Lung cancer, neoplasms, Aged, Cell Proliferation, Oncogenic Signaling, Cell growth, Cancers and Neoplasms, medicine.disease, Non-Small Cell Lung Cancer, respiratory tract diseases, MicroRNAs, Cancer research, Biomarkers, General Pathology
Abstract

Aberrant expression of microRNA-146a (miR-146a) has been reported to be involved in the development and progression of various types of cancers. However, its role in non-small cell lung cancer (NSCLC) has not been elucidated. The aim of this study was to investigate the contribution of miR-146a to various aspects of the malignant phenotype of human NSCLCs. In functional experiments, miR-146a suppressed cell growth, induced cellular apoptosis and inhibited EGFR downstream signaling in five NSCLC cell lines (H358, H1650, H1975, HCC827 and H292). miR-146a also inhibited the migratory capacity of these NSCLC cells. On the other hand, miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR, including both TKIs (gefitinib, erlotinib, and afatinib) and a monoclonal antibody (cetuximab). These effects were independent of the EGFR mutation status (wild type, sensitizing mutation or resistance mutation), but were less potent compared to the effects of siRNA targeting of EGFR. Our results suggest that these effects of miR-146a are due to its targeting of EGFR and NF-κB signaling. We also found, in clinical formalin fixed paraffin embedded (FFPE) lung cancer samples, that low expression of miR-146a was correlated with advanced clinical TNM stages and distant metastasis in NSCLC (P

Published
2013

Catalog

Books, media, physical & digital resources
See catalog results