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1. Additional file 1 of Perceived cardiovascular disease risk and tailored communication strategies among rural and urban community dwellers in Rwanda: a qualitative study

Author

Niyibizi, Jean Berchmans, Okop, Kufre Joseph, Nganabashaka, Jean Pierre, Umwali, Ghislaine, Rulisa, Stephen, Ntawuyirushintege, Seleman, Tumusiime, David, Nyandwi, Alypio, Ntaganda, Evariste, Delobelle, Peter, Levitt, Naomi, and Bavuma, Charlotte M.

Subjects
Data_FILES
Abstract

Additional file 1.

Published
2022
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2. Additional file 1 of Community-driven citizen science approach to explore cardiovascular disease risk perception, and develop prevention advocacy strategies in sub-Saharan Africa: a programme protocol

Author

Okop, Kufre Joseph, Murphy, Kathy, Lambert, Estelle Victoria, Kiya Kedir, Hailemichael Getachew, Rawleigh Howe, Niyibizi, Jean Berchmans, Selemani Ntawuyirushintege, Bavuma, Charlotte, Rulisa, Stephen, Kasenda, Stephen, Chipeta, Effie, Bunn, Christopher, Crampin, Amelia C., Chapotera, Gertrude, King, Abby C., Banchoff, Ann, Winter, Sandra J., and Levitt, Naomi S.

Abstract

Additional file 1. Ethiopia Administrative and Public Health System overview (Example of country administrative structure and public health system)

Published
2021
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3. Implementing the liberalized abortion law in Kigali, Rwanda : Ambiguities of rights and responsibilities among health care providers

Author

Påfs, Jessica, Rulisa, Stephen, Klingberg Allvin, Marie, Binder, Pauline, Musafili, Aimable, and Essén, Birgitta

Subjects
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Post-abortion care, Stigma, education, Health Sciences, Public Health, Global Health, Social Medicine and Epidemiology, Hälsovetenskaper, Maternal near miss, humanities, reproductive and urinary physiology, Maternal morbidity
Abstract

Objective: Rwanda amended its abortions law in 2012 to allow for induced abortion under certain circumstances. We explore how Rwandan health care providers (HCP) understand the law and implement it in their clinical practice. Design: Fifty-two HCPs involved in post-abortion care in Kigali were interviewed by qualitative individual in-depth interviews (n =32) and in focus group discussions (n =5) in year 2013, 2014, and 2016. All data were analyzed using thematic analysis. Findings: HCPs express ambiguities on their rights and responsibilities when providing abortion care. A prominent finding was the uncertainties about the legal status of abortion, indicating that HCPs may rely on outdated regulations. A reluctance to be identified as an abortion provider was noticeable due to fear of occupational stigma. The dilemma of liability and litigation was present, and particularly care providers’ legal responsibility on whether to report a woman who discloses an illegal abortion. Conclusion: The lack of professional consensus is creating barriers to the realization of safe abortion care within the legal framework, and challenge patients right for confidentiality. This bring consequences on girl's and women's reproductive health in the setting. Implications for practice: To implement the amended abortion law and to provide equitable maternal care, the clinical and ethical guidelines for HCPs need to be revisited. © 2019

Published
2020

4. Road traffic crash experience among commercial motorcyclists in Kigali, Rwanda

Author

Joao Ricardo Nickenig Vissoci, Krebs, Elizabeth, Meier, Brian, Vieira, Igor Fiorese, Andrade, Luciano De, Fidele Byiringiro, Rulisa, Stephen, and Staton, Catherine A.

Abstract

Objective: Road traffic injuries (RTI) cause ∼1.2 million deaths and 50 million injuries annually, disproportionately occurring in low- and middle-income countries. Although policy changes and infrastructural developments have continued to contribute to the decrease in RTI-related deaths, limited studies have investigated the relationship between motorcycle taxi driver behaviors and RTIs in Rwanda. This study aims to describe the safety behaviors of commercial motorcyclists in Kigali, Rwanda. Methods: We surveyed 609 commercial motorcyclists in January 2014 then conducted a cross-sectional analysis of the results, including descriptive and bivariate logistic regression analyses. Results: We found that 38.7% of surveyed motorcycle drivers experienced a crash during their lifetime, of which, more than half (n = 134, 56.8%) suffered injuries. Of all injuries, 38.8% (n = 52) resulted in hospitalization, and 14.2% (n = 19) in disability. Among motorcyclists, 100% reported always wearing a helmet, 99% reported always wearing a chin strap, and 98.8% reported always having a passenger helmet. There was an association between sustaining a crash and believing that helmets (p = 0.08) and chin straps (p = 0.05) reduced crash risk. Conclusions: Rwandan commercial motorcyclists demonstrate generally proper safety behaviors, but remain a high-risk occupational group. Road safety policy initiatives have been effective in changing driver behavior regardless of driver safety beliefs.

Published
2020
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5. An international registry for emergent pathogens and pregnancy

Author

Alice Panchaud, Guillaume Favre, Leo Pomar, Manon Vouga, Karoline Aebi-Popp, David Baud, Tallarek Ann-Christin, Strizek Brigitte, Hecher Kurt, Böckenhoff Paul, Schrey-Petersen Susanne, Mullins Edward, Bromley Rebecca, Whitehead Clare, Rolnik Daniel, Deprest Jan, Richter Jute, Gomes Luz Adriana, Bohrer Betania, Carvalho Ribeiro-do-Valle Carolina, Garanhani Surita Fernanda, Schuler-Faccini Lavinia, Osorio Wender Maria Celeste, Da Rocha Oppermann Maria Lucia, Moreira de sa Renato Augusto, Quintana Silvana, Sjaus Ana, Rahman Arifa, Hamel-Thibault Audrey, Nash Christopher, Kakkar Fatima, Berger Howard, Boucoiran Isabelle, Pasquier Jean-Charles, Snelgrove John, Zipursky Jonathan, Lacroix Meagan, Whittle Wendy, Fuenzalida Javiera, Carvajal Jorge, Guerra Canales Manuel, Hernandez Olivia, Yin Mingzhu, Chen Xiang, Qi Xiaolong, Sanín Blair José Enrique, Gonzalez Ricardo, Cano Aguilar Africa, Rodriguez Vicente Agueda, Tubau Navarra Albert, Puertas Prieto Alberto, Cano Garcia Alejandra Maria, Carrascal Cumplido Ana, Villalba Yarza Ana, Filloy Lavia Ana Cristina, Fernandez Alonso Ana Maria, Sanchez Vegazo Garcia Angeles, Goncé Anna, Ruano Garcia Antonio, Sanchez Munoz Antonio, Marcos Puig Beatriz, Munoz Abellana Begona, Garrido Luque Belen, Fernandez Fernandez Camino, Larranaga Azcarate Carlos, Baena Luque Carmen, Orizales Lago Carmen Maria, Alvarez Colomo Cristina, Lesmes Heredia Cristina, Ruiz Aguilar Cristina, Ferriols Perez Elena, Pascual Salvador Elena, Carmona Sanchez Encarnacion, Alvarez Silvares Esther, Canedo Carballeira Esther Maria, Moran Antolin Eva, Muelas Parraga Eva Maria, Oviedo Perez Eva Maria, Gonzalez Carvajal Francisco Jesus, Agudo Iène, Ocerin Bengoa Iratxe, Gastaca Abasolo Irene, Cabello de Alba Fernandez Isabel, Alvarez Javier, Duro Gomez Jorge, Atxotegi Jose, Navarrina Martinez José, Ruiz Aragon José, Sainz Bueno José Antonio, Adanez Garcia Jose Manuel, Broullon Molanes José Roman, Wizner de Alva Juan Carlos, Forcen Acebal Laura, Gonzalez Rodriguez Laura, Aceituno Velasco Longinos, Cerrillos Gonzalez Lucas, Trigo Lucas, Diaz Meca Lucia, Parada Millan M Carmen, Molina Oller Magdalena, Dominguez Gonzalez Manuel, Munoz Chapuli Gutierrez Mar, Caridad Ortiz Herrera Maria, Nieves Quesada Fernandez Maria, Suarez Arana Maria, Teulon Gonzalez Maria, Zafra Bailera Maria, Duenas Carazo Maria Begona, Gonzalez Macias Maria Carmen, Pilar Guadix Martin Maria del, Barbancho Lopez Maria del Carmen, Medina Mallen Maria del Carmen, Pardo Pumar Maria Isabel, Gimeno Gimeno Maria Joaquina, Nunez Valera Maria José, Pelegay Escartin Maria José, Camacho Caro Marta, Garcia Sanchez Marta, Meca Casbas Marta Ruth, Fraca Padilla Mercedes, Ramirez Gomez Mercedes, Catalina Coello Monica, Cruz Lemini Monica, Perez Perez Noelia, Nieto Velasco Olga, Alomar Mateu Onofre, Martinez Perez Oscar, Vaquerizo Ruiz Oscar, Barrio Fernández Pablo Guillermo del, Monteliu Gonzalez Pilar, Prats Rodriguez Pilar, Vivaracho Terrer Porfirio, Gonzales Seoane Raquel, Jimenez Velazquez Raquel, Alvarez Fernandez Rebeca, Lopez Perez Rocio, Ostos Serna Rosa Maria, Redondo Aguilar Rosario, Bernardo Vega Rut, Cano Sandra, Mateos Lopez Silvia, Fernandez Garcia Susana, Soldevilla Perez Susana, Manrique Gomez Tania, Munoz Carmona Vitor, Ko Albert I, Johnson Anthony, Nielsen Saines Karin, Cambou Mary, Grechukhina Olga, Neupane Sahara, Reddy Uma, Shah Zubin, Breton Bénédicte, Garabedian Charles, Bertholdt Charline, Poncelet Christophe, Subtil Damien, Musso Didier, Henry Estelle, Plantefeve Gaetan, Ducarme Guillaume, Pelerin Helene, Dimet Jerome, Cottin Judith, Stiremann Julien, Lambert Véronique, Hcini Najeh, Salomon Laurent, Sentilhes Loïc, Giral Marylene, Mottet Nicolas, Morel Olivier, Rozenberg Patrick, Lucie Sedille, Quibel Thibaud, Karagianni Vasiliki, Equy Véronique, Ville Yves, Carles Gabriel, Ruehl Ina, Cleary Brian, Malone Fergal, Higgins Mary, Geary Michael, Hadar Eran, Malinger Gustavo, Sela Hen, Krajden Haratz Karina, Maymon Ron, Yogev Yariv, De Luca Carmen, De Santis Marco, Rosso Telefono, Atallah David, Boguziene Emilija, Germes Pina Fernando, Van den Akker Thomas, Gil-Guevara Enrique, Marchena Jeannette, Ventura Walter, Pereira Alcides, Ayres de Campos Diogo, Charepe Nadia, Viana Pinto Pedro, Ntasumbumuyange Diomede, Rulisa Stephen, Panchaud Alice, Radan Anda-Petronela, Papadia Andrea, Bloch Andrea, Feki Anis, Muller Brochut Anne-Claude, Toussaint Arnaud, Eggel-Hort Béatrice, Martinez de Tejada Begoña, Frey Tirri Brigitte, Weber Brigitte, Blume Carolin, Monod Cécile, Kahlert Christian, Voekt Cora, Surbek Daniel, Baud David, Bassler Dirk, Mueller Doris, Prentl Elke Barbara, Gerber Eva, Rothe Friederike, Eric Giannoni, Favre Guillaume, Hoesli Irene, Mathis Jérôme, Lepigeon Karine, Aebi-Popp Karoline, Pomar Leo, Schäffer Leonhard, Raio Luigi, Vouga Manon, Huesler Charles Margaret, Rossier Marie-Claude, Hodel Markus, Kaufmann Martin, Gavillet Mathilde, Boulvain Michel, Todesco Bernasconi Monya, Bickle Myriam, Ochsenbein Kölble Nicole, Jarrah Omar, Kanellos Panagiotis, Brasier Lutz Pascale, Capoccia Brugger Romina, Heldstab Sandra, Heldstab Sandra Andrea, Rouiller Cornu Sylvie, Fischer Tina, Winterfeld Ursula, Lambelet Valentine, Rieder Wawrzyniec, Greub Gilbert, Gengler Carole, Patel Rena C, Huespe Miguel Angel, Nieto-Calvache Albaro José, COVI-Preg group, Ann-Christin, T., Brigitte, S., Kurt, H., Paul, B., Susanne, S.P., Edward, M., Rebecca, B., Clare, W., Daniel, R., Jan, D., Jute, R., Adriana, G.L., Betania, B., Carolina, C.R., Fernanda, G.S., Lavinia, S.F., Maria Celeste, O.W., Maria Lucia, DRO, Renato Augusto, M.S., Silvana, Q., Ana, S., Arifa, R., Audrey, H.T., Christopher, N., Fatima, K., Howard, B., Isabelle, B., Jean-Charles, P., John, S., Jonathan, Z., Meagan, L., Wendy, W., Javiera, F., Jorge, C., Manuel, G.C., Olivia, H., Mingzhu, Y., Xiang, C., Xiaolong, Q., José Enrique, S.B., Ricardo, G., Africa, C.A., Agueda, R.V., Albert, T.N., Alberto, P.P., Alejandra Maria, C.G., Ana, C.C., Ana, V.Y., Ana Cristina, F.L., Ana Maria, F.A., Angeles, SVG, Anna, G., Antonio, R.G., Antonio, S.M., Beatriz, M.P., Begona, M.A., Belen, G.L., Camino, F.F., Carlos, L.A., Carmen, B.L., Carmen Maria, O.L., Cristina, A.C., Cristina, L.H., Cristina, R.A., Elena, F.P., Elena, P.S., Encarnacion, C.S., Esther, A.S., Esther Maria, C.C., Eva, M.A., Eva Maria, M.P., Eva Maria, O.P., Francisco Jesus, G.C., Iène, A., Iratxe, O.B., Irene, G.A., Isabel, CAF, Javier, A., Jorge, D.G., Jose, A., José, N.M., José, R.A., José Antonio, S.B., Jose Manuel, A.G., José Roman, B.M., Juan Carlos, W.A., Laura, F.A., Laura, G.R., Longinos, A.V., Lucas, C.G., Lucas, T., Lucia, D.M., M Carmen, P.M., Magdalena, M.O., Manuel, D.G., Mar, MCG, Maria, COH, Maria, NQF, Maria, S.A., Maria, T.G., Maria, Z.B., Maria Begona, D.C., Maria Carmen, G.M., Maria Del, PGM, Maria Del Carmen, B.L., Maria Del Carmen, M.M., Maria Isabel, P.P., Maria Joaquina, G.G., Maria José, N.V., Maria José, P.E., Marta, C.C., Marta, G.S., Marta Ruth, M.C., Mercedes, F.P., Mercedes, R.G., Monica, C.C., Monica, C.L., Noelia, P.P., Olga, N.V., Onofre, A.M., Oscar, M.P., Oscar, V.R., Pablo Guillermo Del, B.F., Pilar, M.G., Pilar, P.R., Porfirio, V.T., Raquel, G.S., Raquel, J.V., Rebeca, A.F., Rocio, L.P., Rosa Maria, O.S., Rosario, R.A., Rut, B.V., Sandra, C., Silvia, M.L., Susana, F.G., Susana, S.P., Tania, M.G., Vitor, M.C., Albert I, K., Anthony, J., Karin, N.S., Mary, C., Olga, G., Sahara, N., Uma, R., Zubin, S., Bénédicte, B., Charles, G., Charline, B., Christophe, P., Damien, S., Didier, M., Estelle, H., Gaetan, P., Guillaume, D., Helene, P., Jerome, D., Judith, C., Julien, S., Véronique, L., Najeh, H., Laurent, S., Loïc, S., Marylene, G., Nicolas, M., Olivier, M., Patrick, R., Sedille, L., Thibaud, Q., Vasiliki, K., Véronique, E., Yves, V., Gabriel, C., Ina, R., Brian, C., Fergal, M., Mary, H., Michael, G., Eran, H., Gustavo, M., Hen, S., Karina, K.H., Ron, M., Yariv, Y., Carmen, L., Marco, S., Telefono, R., David, A., Emilija, B., Fernando, G.P., Thomas, VDA, Enrique, G.G., Jeannette, M., Walter, V., Alcides, P., Diogo, A.C., Nadia, C., Pedro, V.P., Diomede, N., Stephen, R., Alice, P., Anda-Petronela, R., Andrea, P., Andrea, B., Anis, F., Anne-Claude, M.B., Arnaud, T., Béatrice, E.H., Begoña, M.T., Brigitte, F.T., Brigitte, W., Carolin, B., Cécile, M., Christian, K., Cora, V., Daniel, S., David, B., Dirk, B., Doris, M., Elke Barbara, P., Eva, G., Friederike, R., Giannoni, E., Guillaume, F., Irene, H., Jérôme, M., Karine, L., Karoline, A.P., Leo, P., Leonhard, S., Luigi, R., Manon, V., Margaret, H.C., Marie-Claude, R., Markus, H., Martin, K., Mathilde, G., Michel, B., Monya, T.B., Myriam, B., Nicole, O.K., Omar, J., Panagiotis, K., Pascale, B.L., Romina, C.B., Sandra, H., Sandra Andrea, H., Sylvie, R.C., Tina, F., Ursula, W., Valentine, L., Wawrzyniec, R., Gilbert, G., Carole, G., Rena C, P., Miguel Angel, H., and Albaro José, N.C.

Subjects
Diagnostic Screening Programs, medicine.medical_specialty, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, Severe Acute Respiratory Syndrome, Communicable Diseases, Emerging, Risk Assessment, Betacoronavirus, Fetus, Pregnancy, Risk Factors, Pandemic, medicine, Humans, Registries, 610 Medicine & health, Intensive care medicine, Pandemics, Zika Virus Infection, Viral Epidemiology, business.industry, Pregnancy Outcome, Betacoronavirus/growth & development, Betacoronavirus/immunology, Communicable Diseases, Emerging/epidemiology, Communicable Diseases, Emerging/prevention & control, Coronavirus Infections/epidemiology, Diagnostic Screening Programs/standards, Female, Interdisciplinary Placement/methods, Pneumonia, Viral/epidemiology, Pregnancy Outcome/epidemiology, Severe Acute Respiratory Syndrome/epidemiology, Zika Virus/immunology, Zika Virus Infection/epidemiology, COVID-19, Zika Virus, General Medicine, medicine.disease, Interdisciplinary Placement, sars-cov-2, Settore MED/40 - GINECOLOGIA E OSTETRICIA, Coronavirus Infections, business
Published
2020

7. Additional file 1: of The assessment of gestational age: a comparison of different methods from a malaria pregnancy cohort in sub-Saharan Africa

Author

Unger, Holger, Thriemer, Kamala, Ley, Benedikt, Halidou Tinto, Maminata Traoré, Valea, Innocent, Tagbor, Harry, Gifty Antwi, Gbekor, Prosper, Nambozi, Michael, Jean-Bertin Kabuya, Modest Mulenga, Mwapasa, Victor, Chapotera, Gertrude, Mwayiwawo Madanitsa, Rulisa, Stephen, Crop, Maaike, Claeys, Yves, Ravinetto, Raffaella, and D’Alessandro, Umberto

Subjects
body regions, nervous system, fungi, embryonic structures, reproductive and urinary physiology
Abstract

Standard operating procedures (PREGACT study) for obstetric ultrasound for the assessment of embryos and foetuses during pregnancy. (PDF 165 kb)

Published
2019
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8. Additional file 1: of The assessment of gestational age: a comparison of different methods from a malaria pregnancy cohort in sub-Saharan Africa

Author

Unger, Holger, Thriemer, Kamala, Ley, Benedikt, Halidou Tinto, Maminata Traoré, Valea, Innocent, Tagbor, Harry, Gifty Antwi, Gbekor, Prosper, Nambozi, Michael, Jean-Bertin Kabuya, Modest Mulenga, Mwapasa, Victor, Chapotera, Gertrude, Mwayiwawo Madanitsa, Rulisa, Stephen, Crop, Maaike, Claeys, Yves, Ravinetto, Raffaella, and D’Alessandro, Umberto

Subjects
body regions, nervous system, fungi, embryonic structures, reproductive and urinary physiology
Abstract

Standard operating procedures (PREGACT study) for obstetric ultrasound for the assessment of embryos and foetuses during pregnancy. (PDF 165 kb)

Published
2019
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10. First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: A meta-analysis of observational studies

Author

Dellicour, Stephanie, Sevene, Esperança, McGready, Rose, Tinto, Halidou, Mosha, Dominic, Manyando, Christine, Rulisa, Stephen, Desai, Meghna, Ouma, Peter, Oneko, Martina, Vala, Anifa, Rupérez, Maria, Macete, Eusébio, Menéndez, Clara, Nakanabo-Diallo, Seydou, Kazienga, Adama, Valéa, Innocent, Calip, Gregory, Augusto, Orvalho, Genton, Blaise, Njunju, Eric M., Moore, Kerryn A., d’Alessandro, Umberto, Nosten, Francois, terKuile, Feiko, and Krishna, Sanjeev

Subjects
qv_256, wa_108, wa_240, wq_256, wa_310, wq_240, wc_750
Abstract

Background \ud Animal embryotoxicity data, and the scarcity of safety data in human pregnancies, have prevented artemisinin derivatives from being recommended for malaria treatment in the first trimester except in lifesaving circumstances. We conducted a meta-analysis of prospective observational studies comparing the risk of miscarriage, stillbirth, and major congenital anomaly (primary outcomes) among first-trimester pregnancies treated with artemisinin derivatives versus quinine or no antimalarial treatment. \ud \ud Methods and findings\ud Electronic databases including Medline, Embase, and Malaria in Pregnancy Library were searched, and investigators contacted. Five studies involving 30,618 pregnancies were included; four from sub-Saharan Africa (n = 6,666 pregnancies, six sites) and one from Thailand (n = 23,952). Antimalarial exposures were ascertained by self-report or active detection and confirmed by prescriptions, clinic cards, and outpatient registers. Cox proportional hazards models, accounting for time under observation and gestational age at enrollment, were used to calculate hazard ratios. Individual participant data (IPD) meta-analysis was used to combine the African studies, and the results were then combined with those from Thailand using aggregated data meta-analysis with a random effects model. There was no difference in the risk of miscarriage associated with the use of artemisinins anytime during the first trimester (n = 37/671) compared with quinine (n = 96/945; adjusted hazard ratio [aHR] = 0.73 [95% CI 0.44, 1.21], I2 = 0%, p = 0.228), in the risk of stillbirth (artemisinins, n = 10/654; quinine, n = 11/615; aHR = 0.29 [95% CI 0.08–1.02], p = 0.053), or in the risk of miscarriage and stillbirth combined (pregnancy loss) (aHR = 0.58 [95% CI 0.36–1.02], p = 0.099). The corresponding risks of miscarriage, stillbirth, and pregnancy loss in a sensitivity analysis restricted to artemisinin exposures during the embryo sensitive period (6–12 wk gestation) were as follows: aHR = 1.04 (95% CI 0.54–2.01), I2 = 0%, p = 0.910; aHR = 0.73 (95% CI 0.26–2.06), p = 0.551; and aHR = 0.98 (95% CI 0.52–2.04), p = 0.603. The prevalence of major congenital anomalies was similar for first-trimester artemisinin (1.5% [95% CI 0.6%–3.5%]) and quinine exposures (1.2% [95% CI 0.6%–2.4%]). Key limitations of the study include the inability to control for confounding by indication in the African studies, the paucity of data on potential confounders, the limited statistical power to detect differences in congenital anomalies, and the lack of assessment of cardiovascular defects in newborns. \ud \ud Conclusions \ud Compared to quinine, artemisinin treatment in the first trimester was not associated with an increased risk of miscarriage or stillbirth. While the data are limited, they indicate no difference in the prevalence of major congenital anomalies between treatment groups. The benefits of 3-d artemisinin combination therapy regimens to treat malaria in early pregnancy are likely to outweigh the adverse outcomes of partially treated malaria, which can occur with oral quinine because of the known poor adherence to 7-d regimens. \ud \ud Review registration PROSPERO CRD42015032371

Published
2017

11. Additional file 1: of High road utilizers surveys compared to police data for road traffic crash hotspot localization in Rwanda and Sri Lanka

Author

Staton, Catherine, Vijitha De Silva, Krebs, Elizabeth, Andrade, Luciano, Rulisa, Stephen, Badra Mallawaarachchi, Kezhi Jin, Joao RicardoVissoci, and ØStbye, Truls

Abstract

High Road Utilizers Surveys Compared to Police Data for Road Traffic Crash Hotspot Localization in Rwanda and Sri Lanka. (DOCX 28 kb)

Published
2016
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12. A multi-platform metabolomics approach identifies novel biomarkers associated with bacterial diversity in the human vagina

Author

McMillan, Amy, Rulisa, Stephen, Sumarah, Mark, Macklaim, Jean M., Renaud, Justin, Bisanz, Jordan, Gloor, Gregory B., and Reid, Gregor

Subjects
Quantitative Biology - Biomolecules, FOS: Biological sciences, Biomolecules (q-bio.BM)
Abstract

Bacterial vaginosis (BV) increases transmission of HIV, enhances the risk of preterm labour, and its associated malodour impacts the quality of life for many women. Clinical diagnosis primarily relies on microscopy to presumptively detect a loss of lactobacilli and acquisition of anaerobes. This diagnostic does not reflect the microbiota composition accurately as lactobacilli can assume different morphotypes, and assigning BV associated morphotypes to specific organisms is challenging. Using an untargeted metabolomics approach we identify novel biomarkers for BV in a cohort of 131 Rwandan women, and demonstrate that metabolic products in the vagina are strongly associated with bacterial diversity. Metabolites associated with high diversity and clinical BV include 2-hydroxyisovalerate and gamma-hydroxybutyrate (GHB), but not the anaerobic end-product succinate. Low diversity, and high relative abundance of lactobacilli, is characterized by lactate and amino acids. Biomarkers associated with diversity and BV are independent of pregnancy status, and were validated in a blinded replication cohort from Tanzania (n=45), in which we predicted clinical BV with 91% accuracy. Correlations between the metabolome and microbiota identified Gardnerella vaginalis as a putative producer of GHB, and we demonstrate production by this species in vitro. This work provides a deeper understanding of the relationship between the vaginal microbiota and biomarkers of vaginal health and dysbiosis.

Published
2015

13. A randomized, double-blinded, placebo-controlled pilot study of probiotics in active rheumatoid arthritis

Author

Reid, Gregor, Nduti, Nicholas, Sybesma, Wilbert, Kort, Remco, Kollmann, Tobias R., Adam, Rod, Boga, Hamadi, Brown, Eric M., Einerhand, Alexandra, El-Nezami, Hani, Gloor, Gregory B., Kavere, Irene I., Lindahl, Johanna, Manges, Amee, Mamo, Wondu, Martin, Rocio, McMillan, Amy, Obiero, Jael, Ochieng', Pamela A., Onyango, Arnold, Rulisa, Stephen, Salminen, Eeva, Salminen, Seppo, Sije, Antony, Swann, Jonathan R., van Treuren, William, Waweru, Daniel, and Kemp, Steve J.

Abstract

To augment capacity-building for microbiome and probiotic research in Africa, a workshop was held in Nairobi, Kenya, at which researchers discussed human, animal, insect, and agricultural microbiome and probiotics/prebiotics topics. Five recommendations were made to promote future basic and translational research that benefits Africans.

Published
2014

14. MOESM2 of False-negative malaria rapid diagnostic tests in Rwanda: impact of Plasmodium falciparum isolates lacking hrp2 and declining malaria transmission

Author

Kozycki, Christina, Noella Umulisa, Rulisa, Stephen, Mwikarago, Emil, Musabyimana, Jean, Habimana, Jean, Karema, Corine, and Krogstad, Donald

Subjects
parasitic diseases, 3. Good health
Abstract

Additional file 2. PCR products visualized on an agarose gel. DNA is from two thick-smear positive subjects with negative HRP2-based RDTs. Lane 1: 100 bp marker. Lane 2: PCR targeting hrp2 with DNA from subject #1 (shows amplicon of expected size of ~900 bp). Lanes 3–5: PCR with DNA from subject #2. Lane 3 shows the absence of hrp2 amplicons. Lane 4 shows results of multiplex PCR for 18S rRNA with an amplicon of 276 bp (expected size for P. falciparum). Lane 5 shows results of nested PCR with species-specific primers for P. falciparum 18S rRNA with an amplicon of the expected size of 205 bp.

15. MOESM1 of False-negative malaria rapid diagnostic tests in Rwanda: impact of Plasmodium falciparum isolates lacking hrp2 and declining malaria transmission

Author

Kozycki, Christina, Noella Umulisa, Rulisa, Stephen, Mwikarago, Emil, Musabyimana, Jean, Habimana, Jean, Karema, Corine, and Krogstad, Donald

Subjects
parasitic diseases, 3. Good health
Abstract

Additional file 1. Primer sequences used to amplify hrp2 and P. falciparum, P. vivax, P. malariae and P. ovale 18S rRNA, expected product sizes and PCR conditions.

16. MOESM2 of False-negative malaria rapid diagnostic tests in Rwanda: impact of Plasmodium falciparum isolates lacking hrp2 and declining malaria transmission

Author

Kozycki, Christina, Noella Umulisa, Rulisa, Stephen, Mwikarago, Emil, Musabyimana, Jean, Habimana, Jean, Karema, Corine, and Krogstad, Donald

Subjects
parasitic diseases, 3. Good health
Abstract

Additional file 2. PCR products visualized on an agarose gel. DNA is from two thick-smear positive subjects with negative HRP2-based RDTs. Lane 1: 100 bp marker. Lane 2: PCR targeting hrp2 with DNA from subject #1 (shows amplicon of expected size of ~900 bp). Lanes 3–5: PCR with DNA from subject #2. Lane 3 shows the absence of hrp2 amplicons. Lane 4 shows results of multiplex PCR for 18S rRNA with an amplicon of 276 bp (expected size for P. falciparum). Lane 5 shows results of nested PCR with species-specific primers for P. falciparum 18S rRNA with an amplicon of the expected size of 205 bp.

17. MOESM1 of False-negative malaria rapid diagnostic tests in Rwanda: impact of Plasmodium falciparum isolates lacking hrp2 and declining malaria transmission

Author

Kozycki, Christina, Noella Umulisa, Rulisa, Stephen, Mwikarago, Emil, Musabyimana, Jean, Habimana, Jean, Karema, Corine, and Krogstad, Donald

Subjects
parasitic diseases, 3. Good health
Abstract

Additional file 1. Primer sequences used to amplify hrp2 and P. falciparum, P. vivax, P. malariae and P. ovale 18S rRNA, expected product sizes and PCR conditions.

18. Harnessing microbiome and probiotic research in sub-Saharan Africa: recommendations from an African workshop

Author

Reid, Gregor, Nduti, Nicholas, Sybesma, Wilbert, Kort, Remco, Kollmann, Tobias R, Adam, Rod, Boga, Hamadi, Brown, Eric M, Einerhand, Alexandra, El-Nezami, Hani, Gloor, Gregory B, Kavere, Irene I, Lindahl, Johanna, Manges, Amee, Mamo, Wondu, Martin, Rocio, McMillan, Amy, Obiero, Jael, Ochieng’, Pamela A, Onyango, Arnold, Rulisa, Stephen, Salminen, Eeva, Salminen, Seppo, Sije, Antony, Swann, Jonathan R, Van Treuren, William, Waweru, Daniel, and Kemp, Steve J

Subjects
2. Zero hunger, 3. Good health
Abstract

To augment capacity-building for microbiome and probiotic research in Africa, a workshop was held in Nairobi, Kenya, at which researchers discussed human, animal, insect, and agricultural microbiome and probiotics/prebiotics topics. Five recommendations were made to promote future basic and translational research that benefits Africans.

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