1. Clones of cells switch from reduction to enhancement of size variability in Arabidopsis sepals
- Author
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Tsugawa, Satoru, Hervieux, Nathan, Kierzkowski, Daniel, Routier-Kierzkowska, Anne-Lise, Sapala, Aleksandra, Hamant, Olivier, Smith, Richard S., Roeder, Adrienne H. K., Boudaoud, Arezki, Li, Chun-Biu, Riken, RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), Reproduction et développement des plantes (RDP), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Recherche Agronomique (INRA)-École normale supérieure - Lyon (ENS Lyon), University of Cambridge [UK] (CAM), Max Planck Institute for Plant Breeding Research (MPIPZ), Université de Montréal (UdeM), Cornell University [New York], Stockholm University, Human Frontier Science Program RGP0008/2013, RIKEN K1731017, École normale supérieure de Lyon (ENS de Lyon)-Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)
- Subjects
homogénéisation ,clone ,taille ,cell size variability ,size uniformization ,cell growth heterogeneity ,Biologie du développement ,hétérogénéité ,cellule ,Development Biology ,croissance cellulaire ,[SDV.BDD]Life Sciences [q-bio]/Development Biology - Abstract
International audience; Organs form with remarkably consistent sizes and shapes during development, whereas a high variability in growth is observed at the cell level. Given this contrast, it is unclear how such consistency in organ scale can emerge from cellular behavior. Here, we examine an intermediate scale, the growth of clones of cells in Arabidopsis sepals. Each clone consists of the progeny of a single progenitor cell. At early stages, we find that clones derived from a small progenitor cell grow faster than those derived from a large progenitor cell. This results in a reduction in clone size variability, a phenomenon we refer to as size uniformization. By contrast, at later stages of clone growth, clones change their growth pattern to enhance size variability, when clones derived from larger progenitor cells grow faster than those derived from smaller progenitor cells. Finally, we find that, at early stages, fast growing clones exhibit greater cell growth heterogeneity. Thus, cellular variability in growth might contribute to a decrease in the variability of clones throughout the sepal.
- Published
- 2017
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