1. An area-based study on intrapartum antibiotic prophylaxis for preventing group B streptococcus early-onset disease: advances and limitations
- Author
-
Luana Pini, Lucia Gambini, Alberto Berardi, Fabio Facchinetti, Irene Papa, Claudio Chiossi, Maria Grazia Capretti, Valentina Fiorini, Luigi Memo, Fabrizio Ferrari, Maria Letizia Bacchi Reggiani, Maria Vittoria Rizzo, Andrea Zucchini, Marcello Lanari, Cecilia Rossi, Annalisa Bastelli, Sara Gavioli, Berardi, Alberto, Rossi, Cecilia, Bacchi Reggiani, Maria Letizia, Bastelli, Annalisa, Capretti, Maria Grazia, Chiossi, Claudio, Fiorini, Valentina, Gambini, Lucia, Gavioli, Sara, Lanari, Marcello, Memo, Luigi, Papa, Irene, Pini, Luana, Rizzo, Maria Vittoria, Zucchini, Andrea, Facchinetti, Fabio, and Ferrari, Fabrizio
- Subjects
medicine.medical_specialty ,Group B streptococcus ,Prom ,Group B ,sepsis ,03 medical and health sciences ,0302 clinical medicine ,prevention ,newborn ,Pregnancy ,Risk Factors ,intrapartum antibiotic prophylaxis ,risk factors ,030225 pediatrics ,Positive predicative value ,Streptococcal Infections ,Medicine ,Humans ,030212 general & internal medicine ,Antibiotic prophylaxis ,Full Term ,Retrospective Studies ,Group B streptococcu ,Receiver operating characteristic ,business.industry ,Obstetrics ,Rectum ,Obstetrics and Gynecology ,Odds ratio ,Antibiotic Prophylaxis ,Infectious Disease Transmission, Vertical ,Anti-Bacterial Agents ,Perinatal Care ,intrapartum antibiotic prophylaxi ,risk factor ,Pediatrics, Perinatology and Child Health ,Vagina ,Gestation ,Premature Birth ,Ampicillin ,Female ,Guideline Adherence ,business - Abstract
INTRODUCTION: The prevalence of maternal group-B-streptococcus (GBS) colonization and risk factors (RFs) for neonatal early-onset disease (EOD) in Europe are poorly defined. Large-scale information concerning adherence to recommendations for preventing GBS-EOD are lacking. MATERIALS AND METHODS: This was a 3-month retrospective area-based study including all regional deliveries ≥35 weeks' gestation (in 2012). The sensitivity, specificity, positive and negative predictive values, odds ratio and receiver operating characteristic (ROC) curve for intrapartum antibiotic prophylaxis (IAP) among full-term and preterm deliveries and prolonged membrane rupture (PROM) were calculated. RESULTS: Among 7133 women, 259 (3.6%) were preterm (35-36 weeks' gestation). Full-term women were 6874, and 876 (12.7%) had at least 1 RF. Most women (6495) had prenatal screening and 21.4% (1390) were GBS positive. IAP was given to 2369 (33.2%) women (preterm, n = 166; full term, n = 2203). Compared to full-term, preterm women were less likely to receive IAP when indicated (73.2% versus 90.3%, p
- Published
- 2016