Search

Your search keyword '"Ristau J"' showing total 6 results
Start Over Author "Ristau J" Database OpenAIRE
6 results on '"Ristau J"'

2. Additional file 1 of MR-guided adaptive versus ITV-based stereotactic body radiotherapy for hepatic metastases (MAESTRO): a randomized controlled phase II trial

Author

Hoegen, P., Zhang, K. S., Tonndorf-Martini, E., Weykamp, F., Regnery, S., Naumann, P., Lang, K., Ristau, J., Körber, S. A., Dreher, C., Buchele, C., Rippke, C., Renkamp, C. K., Paul, K. M., König, L., Büsch, C., Krisam, J., Sedlaczek, O., Schlemmer, H.-P., Niyazi, M., Corradini, S., Debus, J., Klüter, S., and Hörner-Rieber, J.

Subjects
ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Data_FILES
Abstract

Additional file 1. Study protocol.

Published
2022
Full Text
View/download PDF

6. MNK2 governs the macrophage antiinflammatory phenotype

Author

Anne Laure Joly, Christina Seitz, Samuel E.J. Preston, Majken Wallerius, Talin Ebrahimian, Stephanie Lehoux, Sonia V. del Rincón, Jonas Bergh, Ola Larsson, Johannes Ristau, Kristian Pietras, Laia Masvidal, Yangxun Pan, John Andersson, Mario Leonardo Squadrito, Christophe Goncalves, Luigi Naldini, Tatjana Wallmann, Hui Liu, Thomas Kerzel, Margarita Bartish, Sabrina de Souza Ferreira, Dongmei Tong, Charlotte Rolny, Vincent van Hoef, Bartish, M., Tong, D., Pan, Y., Wallerius, M., Liu, H., Ristau, J., de Souza Ferreira, S., Wallmann, T., van Hoef, V., Masvidal, L., Kerzel, T., Joly, A. -L., Goncalves, C., Preston, S. E. J., Ebrahimian, T., Seitz, C., Bergh, J., Pietras, K., Lehoux, S., Naldini, L., Andersson, J., Squadrito, M. L., del Rincon, S. V., Larsson, O., and Rolny, C.

Subjects
Primary Cell Culture, MNK2, Mice, Transgenic, Protein Serine-Threonine Kinases, Proinflammatory cytokine, Mice, Cell Plasticity, Neoplasms, Gene expression, EIF4E, Macrophage, Animals, Humans, Naphthyridines, Phosphorylation, PI3K/AKT/mTOR pathway, Multidisciplinary, Chemistry, Kinase, T cell activation, Macrophages, TOR Serine-Threonine Kinases, Tumor-associated macrophages, MRNA translation, Biological Sciences, Coculture Techniques, Cell biology, Gene Expression Regulation, Neoplastic, Disease Models, Animal, Eukaryotic Initiation Factor-4E, Gene Knockdown Techniques, MCF-7 Cells, Female, Tumor Escape, Signal Transduction
Abstract

Tumor-associated macrophages (TAMs) continuously fine tune their immune modulatory properties, but how gene expression programs coordinate this immune cell plasticity is largely unknown. Selective mRNA translation, controlled by MNK1/MNK2 and mTOR pathways impinging on eIF4E, facilitates reshaping of proteomes without changes in abundance of corresponding mRNAs. Using polysome profiling developed for small samples we show that, during tumor growth, gene expression in TAMs is predominately modulated via mRNA-selective changes in translational efficiencies. These alterations in gene expression paralleled accumulation of antiinflammatory macrophages with augmented phosphorylation of eIF4E, a target of the MNK1 and MNK2 kinases, known to selectively modulate mRNA translation. Furthermore, suppression of the MNK2, but not the mTOR signaling pathway, reprogrammed antiinflammatory macrophages toward a proinflammatory phenotype with the ability to activate CD8(+) T cells. Thus, selective changes of mRNA translation depending on MNK2 signaling represents a key node regulating macrophage antiinflammatory functions.

Published
2020

Catalog

Books, media, physical & digital resources
See catalog results