1. Inflammatory bactericidal lectin RegIIIβ: Friend or foe for the host?
- Author
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Tsuyoshi Miki, Wolf-Dietrich Hardt, and Nobuhiko Okada
- Subjects
Diarrhea ,Salmonella typhimurium ,0301 basic medicine ,Microbiology (medical) ,Salmonella ,infectious diarrhea ,Biology ,RegIIIβ ,medicine.disease_cause ,vitamin B6 ,Microbiology ,Lipid A ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Intestinal mucosa ,microbiota ,medicine ,Bacteroides ,Animals ,Homeostasis ,Intestinal Mucosa ,Salmonella Infections, Animal ,Gastroenterology ,Proteins ,Lectin ,biology.organism_classification ,Vitamin B 6 ,Addendum ,Anti-Bacterial Agents ,Gastrointestinal Microbiome ,030104 developmental biology ,Infectious Diseases ,chemistry ,Bacterial Translocation ,Mutation ,biology.protein ,Peptidoglycan ,Infectious diarrhea ,Microbiota ,Vitamin B6 ,medicine.symptom ,030217 neurology & neurosurgery ,Bacteria - Abstract
In the inflamed gut, the bactericidal lectin RegIIIβ is massively produced by intestinal mucosa. RegIIIβ binds peptidoglycan and lipid A respectively, and thus can kill certain Gram-positive and Gram-negative bacteria, including the gut commensal microbiota and enteropathogenic bacteria. Considering the expression pattern and bactericidal activity, RegIIIβ is believed to be a host defense factor for protecting against the infection with enteropathogenic bacteria. However, it was poorly understood how RegIIIβ recognizes the target bacteria and kill them, and how RegIIIβ plays role(s) in infectious diarrhea. Therefore, our recent study has focused on RegIIIβ-target recognition, killing of Gram-negative bacteria, and host protective functions of RegIIIβ for infectious diarrhea inflicted by Salmonella Typhimurium. Here, we discuss novel insights into the protective role of RegIIIβ in infectious diarrhea, and propose avenues towards novel therapeutic interventions for Salmonella diarrhea., Gut Microbes, 9 (2), ISSN:1949-0976, ISSN:1949-0984
- Published
- 2017
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