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Objective: Owing to recent advances in understanding of the active functional states exhibited within glioblastoma (GBM), intra-tumoral cellular signaling has moved into focus of neuro-oncological research. In our study, we aim to explore the role of transcellular electrical signaling and investigate [for full text, please go to the a.m. URL]

Objective: An understanding of the diversity of T cell response and clonality in the inherently heterogeneous glioblastoma (GBM) is of paramount importance to explore underlying mechanisms of anti-tumor immunity. Here, we present SPatial T-Cell Receptor sequencing (SPTCR-seq), a novel method to integrate [for full text, please go to the a.m. URL]

Objective: In malignant brain tumours, crosstalk and adaptation of brain resident and infiltrating myeloid cells form an immunosuppressive environment that causes dysfunctional activation of the T cells and leads to an inadequate immune response. Most recently, checkpoint inhibition (PD-1) failed to[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Invariably, malignant glioma develops resistance against temozolomide (TMZ) chemotherapy during the course of the disease through clonal selection of resistant cells. Autocrine glutamate signalling via metabotropic glutamate receptors (mGluR) was reported to sustain malignant hallmarks, however[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie