1. Standardized MRD quantification in European ALL trials: proceedings of the second international symposium on MRD assessment in Kiel, Germany, 18-20 September 2008
- Author
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Brüggemann, M, Schrauder, A, Raff, T, Pfeifer, H, Dworzak, M, Ottmann, Og, Asnafi, V, Baruchel, A, Bassan, R, Benoit, Y, Biondi, A, Cavé, H, Dombret, H, Fielding, Ak, Foa, Roberto, Gökbuget, N, Goldstone, Ah, Goulden, N, Henze, G, Hoelzer, D, JANKA SCHAUB GE, Macintyre, Ea, Pieters, R, Rambaldi, A, Ribera, Jm, Schmiegelow, K, Spinelli, O, Stary, J, VON STACKELBERG, A, Kneba, M, Schrappe, M, VAN DONGEN JJ, EUROPEAN WORKING GROUP FOR ADULT ACUTE LYMPHOBLASTIC LEUKEMIA EWALL, BFM SG, INTERNATIONAL BERLIN FRANKFURT MÜNSTER STUDY GROUP I., Pediatrics, Immunology, Brüggemann, M, Schrauder, A, Raff, T, Pfeifer, H, Dworzak, M, Ottmann, O, Asnafi, V, Baruchel, A, Bassan, R, Benoit, Y, Biondi, A, Cavé, H, Dombret, H, Fielding, A, Foà, R, Gökbuget, N, Goldstone, A, Goulden, N, Henze, G, Hoelzer, D, Janka Schaub, G, Macintyre, E, Pieters, R, Rambaldi, A, Ribera, J, Schmiegelow, K, Spinelli, O, Stary, J, von Stackelberg, A, Kneba, M, Schrappe, M, and van Dongen, J
- Subjects
Cancer Research ,medicine.medical_specialty ,Pediatrics ,Neoplasm, Residual ,Fusion Proteins, bcr-abl ,Context (language use) ,Acute lymphoblastic leukemia ,Polymerase Chain Reaction ,hemic and lymphatic diseases ,Medicine ,Humans ,Medical physics ,Flow cytometry ,Gene Rearrangement ,MRD Response ,Adult all ,Genes, Immunoglobulin ,business.industry ,Minimal residual disease ,Hematology ,Gene rearrangement ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,body regions ,Clinical trial ,MRD ,PCR ,Oncology ,Complete MRD Response ,MRD Reappearance ,business ,ALL - Abstract
Assessment of minimal residual disease (MRD) has acquired a prominent position in European treatment protocols for patients with acute lymphoblastic leukemia (ALL), on the basis of its high prognostic value for predicting outcome and the possibilities for implementation of MRD diagnostics in treatment stratification. Therefore, there is an increasing need for standardization of methodologies and harmonization of terminology. For this purpose, a panel of representatives of all major European study groups on childhood and adult ALL and of international experts on PCR- and flow cytometry-based MRD assessment was built in the context of the Second International Symposium on MRD assessment in Kiel, Germany, 18-20 September 2008. The panel summarized the current state of MRD diagnostics in ALL and developed recommendations on the minimal technical requirements that should be fulfilled before implementation of MRD diagnostics into clinical trials. Finally, a common terminology for a standard description of MRD response and monitoring was established defining the terms 'complete MRD response', 'MRD persistence' and 'MRD reappearance'. The proposed MRD terminology may allow a refined and standardized assessment of response to treatment in adult and childhood ALL, and provides a sound basis for the comparison of MRD results between different treatment protocols.
- Published
- 2010