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Satellite DNA (satDNA) is an abundant class of tandemly repeated noncoding sequences, showing high rate of change in sequence, abundance, and physical location. However, the mechanisms promoting these changes are still controversial. The library model was put forward to explain the conservation of some satDNAs for long periods, predicting that related species share a common collection of satDNAs, which mostly experience quantitative changes. Here, we tested the library model by analyzing three satDNAs in ten species of Schistocerca grasshoppers. This group represents a valuable material because it diversified during the last 7.9 Myr across the American continent from the African desert locust (Schistocerca gregaria), and this thus illuminates the direction of evolutionary changes. By combining bioinformatic and cytogenetic, we tested whether these three satDNA families found in S. gregaria are also present in nine American species, and whether differential gains and/or losses have occurred in the lineages. We found that the three satDNAs are present in all species but display remarkable interspecies differences in their abundance and sequences while being highly consistent with genus phylogeny. The number of chromosomal loci where satDNA is present was also consistent with phylogeny for two satDNA families but not for the other. Our results suggest eminently chance events for satDNA evolution. Several evolutionary trends clearly imply either massive amplifications or contractions, thus closely fitting the library model prediction that changes are mostly quantitative. Finally, we found that satDNA amplifications or contractions may influence the evolution of monomer consensus sequences and by chance playing a major role in driftlike dynamics. Fil: Palacios-Gimenez, Octavio M.. Uppsala Universitet; Suecia Fil: Milani, Diogo. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil Fil: Song, Hojun. Texas A&M University; Estados Unidos Fil: Marti, Dardo Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas; Argentina Fil: López-León, Maria D.. Universidad de Granada; España Fil: Ruiz-Ruano, Francisco J.. Uppsala Universitet; Suecia Fil: Camacho, Juan Pedro M.. Universidad de Granada; España Fil: Cabral-de-Mello, Diogo C.. Universidade Estadual Paulista Julio de Mesquita Filho; Brasil

The germline-restricted chromosome (GRC) of songbirds represents an extraordinary and taxonomically widespread example of programmed DNA elimination. Despite its apparent indispensability in songbirds, we still know very little about the GRC’s genetic composition, function, and evolutionary significance. Here we assembled the GRC in two closely related species, the common and thrush nightingale. We identified 585 and 406 genes on the GRC of each species, respectively, many of them present in multiple copies. Interestingly, the GRC gene content differed dramatically between the two species, with only 192 genes being shared despite only 1.8 million years of species divergence. The chromosome appears to be under little selective pressure, with most GRC genes being present in pseudogenized fragments. Only one gene, cpeb1, had a complete coding region in all examined individuals of the two species and showed no copy number variation. The addition of this gene to the GRC corresponds with the earliest estimates of the GRC origin, making it a good candidate for the functional indispensability of the GRC in songbirds.

La familia y sus integrantes son susceptibles a múltiples eventos en el trascurrir del ciclo vital familiar, no todos los eventos son esperados, algunos generan alteraciones tanto individuales como grupales, como por ejemplo la gestación adolescente. En este sentido, esta investigación buscó conocer la experiencia del rol del padre y de la madre adolescentes gestantes en la familia. Los resultados ayudaron a describir el contexto de las familias de los y las adolescentes y a identificar el rol de los y las adolescentes gestantes. Se realizo un estudio de enfoque cualitativo, de recolección de datos no estandarizado, ni predeterminado, a partir de las entrevistas a profundidad a doce jóvenes, nueve mujeres y tres hombres, con un promedio de edad de 15.6 años. Se obtuvieron familiogramas y se estudiaron con base en lo propuesto por Mcgoldrik y Gerson. También se ejecutó análisis de contenido de la información a partir de algunos lineamientos propuestos por Krippendorff. Se halló que, el contexto de la familia del adolescente tiene una gran diversidad y se encuentra marcado por las dificultades económicas, sociales, de desempleo, de desplazamiento y los bajos salarios. Se evidenció que la pauta de repetición de la gestación a temprana edad es un factor predisponente para las familias, el cual se presenta de generación en generación. La experiencia del rol de los y las adolescentes gestantes se enmarco en seis categorías finales a saber. Se concluye: que los adolescentes experimentan sucesos de la vida de forma única e irrepetible en sus familias; la gestación trae consigo cambios en el proyecto de vida y en los hábitos de la persona; se enfrentan a un rol para el cual cognitivamente no se encuentran maduros para asumirlo. Por tanto, la transición al rol de padres es un proceso difícil y duro para ellos, con expresión de sentimientos de nervios, temor, pena, incertidumbre, miedo, tristeza, decepción, anhelo y felicidad. Comparten sus tareas con sus padres y en algunos casos con sus abuelos. Se recomienda crear estrategias basadas en la comunicación y la aceptación del rol materno desde la vivencia para lograr llegar al anhelo de la gestación. (Texto tomado de la fuente) The family and its members are susceptible to multiple events in the course of the family life cycle, not all events are expected, some generate both individual and group alterations, such as adolescent pregnancy. In this sense, this research sought to know the experiences of the father and mother of pregnant adolescents in the family. The results helped describe the context of the families of the adolescents and identify the role of the pregnant adolescents. A study with a qualitative approach was carried out, collecting data that was neither standardized nor predetermined, based on in-depth interviews with twelve young people, nine women and three men, with an average age of 15.6 years. Familiograms were obtained and studied based on what was proposed by McGoldrick and Gerson. Information content analysis was also carried out based on some guidelines proposed by Krippendorff. It was discovered that the adolescent's family context is diverse and marked by economic, social, and unemployment difficulties, as well as low wages. It was evidenced that the pattern of repeated gestation at an early age is a predisposing factor for families and occurs from generation to generation. The experience of the role of pregnant adolescents was framed in six final categories, viz. It is concluded that adolescents experience life events in their families in a unique and unrepeatable way; pregnancy changes the life project and the person's habits; and they face a role for which they are not cognitively mature. Therefore, the transition to the role of parents is a difficult and hard process for them, with expressions of feelings of nervousness, fear, grief, uncertainty, fear, sadness, disappointment, longing, and happiness. They share their tasks with their parents and, in some cases, with their grandparents. It is recommended to create strategies based on communication and the acceptance of the maternal role from experience to achieve the desire for pregnancy. Maestría Maestría en Enfermería con Énfasis en Salud Familiar Esta investigación se enmarcó en un estudio de enfoque cualitativo al buscar conocer, describir, explicar, comprobar y predecir la experiencia del rol del padre y de la madre adolescente gestante

We thankMelanie Schneider and Christine Baumgartner for support with molecular work, Martin Irestedt for help with DNA extractions for the 10X samples, Shouwen Ma for discussion on microscopic image processing, Keren Sadanandan for discussion on tanglegram analysis, and Katrin Martin, Isabel Schmelcher, Claudia Scheicher, Sonja Bauer, Edith Bodendorfer, Jane Didsbury, Annemarie Gr_otsch, Andrea Kortner, Petra Neubauer, Frances Weigel, and Barbara W_orle for animal care and help with breeding zebra finches. We thank Frank R_o ss ler for providing the castanotis x guttata hybrid male, and Leo Joseph and the Australian National Wildlife Collection for providing testis and liver samples from a wild T. g. castanotis individual. We thank Leo Joseph, Julie Blommaert, Octavio Palacios, Simone Fouch~e, and three anonymous reviewers for comments on the manuscript. Some of the computations were performed on resources provided by the Swedish National Infrastructure for Computing through the Uppsala Multidisciplinary Center for Advanced Computational Science. We acknowledge support from the National Genomics Infrastructure in Stockholm funded by Science for Life Laboratory, the Knut and AliceWallenberg Foundation, and the Swedish Research Council. This research was supported by the Max Planck Society (to B.K.), the Swedish Research Council Formas (2017-01597 and 2020-04436 to A.S.), and the Swedish Research Council Vetenskapsr~adet (2016-05139 to A.S.). Y.P. was part of the International Max Planck Research School for Organismal Biology. F.J.R.-R. was supported by a postdoctoral fellowship from Sven och Lilly Lawskis fond and a Marie Curie Individual Fellowship (875732)., Songbirds have one special accessory chromosome, the so-called germline-restricted chromosome (GRC), which is only present in germline cells and absent from all somatic tissues. Earlier work on the zebra finch (Taeniopygia guttata castanotis) showed that the GRC is inherited only through the female line—like the mitochondria—and is eliminated from the sperm during spermatogenesis. Here, we show that the GRC has the potential to be paternally inherited. Confocal microscopy using GRC-specific fluorescent in situ hybridization probes indicated that a considerable fraction of sperm heads (1 to 19%) in zebra finch ejaculates still contained the GRC. In line with these cytogenetic data, sequencing of ejaculates revealed that individual males from two families differed strongly and consistently in the number of GRCs in their ejaculates. Examining a captive-bred male hybrid of the two zebra finch subspecies (T. g. guttata and T. g. castanotis) revealed that the mitochondria originated from a castanotis mother, whereas the GRC came from a guttata father. Moreover, analyzing GRC haplotypes across nine castanotis matrilines, estimated to have diverged for up to 250,000 y, showed surprisingly little variability among GRCs. This suggests that a single GRC haplotype has spread relatively recently across all examined matrilines. A few diagnostic GRC mutations that arose since this inferred spreading suggest that the GRC has continued to jump across matriline boundaries. Our findings raise the possibility that certain GRC haplotypes could selfishly spread through the population via occasional paternal transmission, thereby outcompeting other GRC haplotypes that were limited to strict maternal inheritance, even if this was partly detrimental to organismal fitness., National Genomics Infrastructure in Stockholm - Science for Life Laboratory, Knut & Alice Wallenberg Foundation, Swedish Research Council, European Commission, Max Planck Society, Foundation CELLEX, Swedish Research Council Swedish Research Council Formas 2017-01597 2020-04436, Swedish Research Council 2016-05139, Sven och Lilly Lawskis fond, European Commission 875732

Cette étude essaie de dévoiler la présence des éléments culturels évidents et des non-dits dans certains ouvrages appartenant au domaine de la bande dessinée française et francophone, tout en proposant un parcours d’adaptation et de réutilisation didactiques à travers l’imitation, la création et la mise en scène d’extraits de bande dessinée contemporaine. Partant d’une analyse diachronique qui considère les fondements de la bande dessinée en langue française, notre démarche devient synchronique pour ainsi nous pencher sur les piliers qui structurent cette manifestation artistique : texte et image. Ne considérant pas pour l’instant la disposition ou structure des vignettes à l’intérieur des ouvrages, notre travail s’intéresse plutôt aux rapports entre les gestes et le cadre d’action des personnages d’une part, et le message écrit d’autre part. Vecteurs d’une composante culturelle visible ou masquée, leur interaction chez le lecteur aide à soulever les marques culturelles ayant trait à la langue cible et à les mettre en évidence lors des activités de théâtralisation., Synergies Espagne n° 14 - 2021 p. 267-279 - GERFLINT - URL: https://gerflint.fr/Base/Espagne14/palomo.pdf

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Additional file 4: Dataset 3. Coverage levels of the 21 protein-coding genes found in the A. scabripinnis and A. paranae B chromosomes. gDNA coverage is shown as number of copies. Additionally, we add a track showing the position of the B-specific SNPs found in the A. scabripinnis libraries. The dotted lines delimit the CDS region and the shaded zones indicate the regions amplified in the qPCR experiments. The coverage pattern attributed to each gene can be found in the Table 1.

Departamento de Deporte e Informática

Departamento de Deporte e Informática

H2020 Marie Sklodowska-Curie Actions, Grant/Award Number: 658706; Ministerio de Ciencia, Innovacion y Universidades, Grant/Award Number: PID2019-104952GB-I00/AEI/10.13039/501100011033, The barcoding of the mitochondrial COX1 gene has been instrumental in cataloguing the tree of life, and in providing insights in the phylogeographic history of species. Yet, this strategy has encountered difficulties in major clades characterized by large genomes, which contain a high frequency of nuclear pseudogenes originating from the mitochondrial genome (numts). Here, we use the meadow grasshopper (Chorthippus parallelus), which possesses a giant genome of ~13 Gb, to identify mitochondrial genes that are underrepresented as numts, and test their use as informative phylogeographic markers. We recover the same full mitochondrial sequence using both whole genome and transcriptome sequencing, including functional protein‐coding genes and tRNAs. We show that a region of the mitogenome containing the COX1 gene, typically used in DNA barcoding, has disproportionally higher diversity and coverage than the rest of the mitogenome, consistent with multiple insertions of that region into the nuclear genome. By designing new markers in regions of less elevated diversity and coverage, we identify two mitochondrial genes that are less likely to be duplicated as numts. We show that, while these markers show high levels of incomplete lineage sorting between subspecies, as expected for mitochondrial genes, genetic variation reflects their phylogeographic history accurately. These findings allow us to identify useful mitochondrial markers for future studies in C. parallelus, an important biological system for evolutionary biology. More generally, this study exemplifies how non‐PCR‐based methods using next‐generation sequencing can be used to avoid numts in species characterized by large genomes, which have remained challenging to study in taxonomy and evolution., H2020 Marie Sklodowska-Curie Actions 658706, Ministerio de Ciencia, Innovacion y Universidades PID2019-104952GB-I00/AEI/10.13039/501100011033

The Working Group on Pathology and Diseases of Marine Organisms (WGPDMO) investigates diseases and pathology in wild and farmed finfish, shellfish and crustaceans. This report describes new disease trends in wild and farmed fish and shellfish in the ICES area, based on national reports from fourteen member countries. Notable reports for wild fish included a widening geographic scope of the enigmatic “red skin disease” in wild Atlantic salmon, with reports now from Norway, Scotland and Ireland as well as the Baltic Sea countries where it was originally observed; increased prevalences of Ichthyophonus sp. infection in herring from Iceland and mackerel from Norway, suggesting potentially increased affects of this pathogen on wild fish in the north; and the first detection of eel rhabdovirus (EVEX) in England and Wales since the 1980s. Detection of piscine orthoreovirus (PRV) in exotic pink salmon straying from cultivation in Russian rivers to Norway raised questions about potential disease interactions between pink salmon and farmed Atlantic salmon that deserve further attention. Reports of diseases in farmed fish included the first detections of infectious pancreatic necrosis virus (IPNV, pathogenic genogroup 5) and Parvicapsula pseudobranchicola in Atlantic salmon from Iceland, increased detection of Pasteurella skyensis in Atlantic salmon in Scotland, and increased detection of furunculosis caused by Aeromonas salmonicida in Atlantic salmon from Ireland. Sea lice parasitism and complex gill disease (CGD) remain highly significant concerns for Atlantic salmon aquaculture, with reports for 2019 noting increasing prevalences and impacts of both.Notable reports of diseases for shellfish included an outbreak of Haplosporidium costale in cultured Pacific oysters in France; mortality caused by Vibrio aestuarianus in cultured Pacific oysters in Scotland and Ireland, with additional and unusual detection of bacteria belonging to the Vibrio splendidus clade in association with Pacific oyster mortality in Ireland; mortality caused by a coccidian parasite in wild bay scallops in the USA; and documented expansions of the distributions of Bonamia ostreae in flat oysters in Scotland and Marteilia refringens in blue mussels in Norway.The group also summarized work on the role of Vibrio pathogens in contributing to mortalities in shellfish aquaculture as well as seafood-associated disease risks in humans, on the contemporary status of oyster pathogen Bonamia ostreae, on complex gill disease in salmon, on emerging health issues affecting wild salmonids of the Baltic region, and on disease considerations related to cleaner-fish use in salmon culture. The group additionally discussed the status and future directions of the ICES Identification Leaflets for Diseases and Parasites of Fish and Shellfish, and priorities for their work from 2021, potentially including health threats to endangered pen shells in the Mediterranean; eel diseases; and a consideration of which host-pathogen systems might be most promising for management through selective breeding. Group members published two new ICES Identification Leaflets for Diseases and Parasites in Fish and Shellfish in 2019 and five new leaflets are planned for completion in 2020.

The genomic abundance of different types of repetitive DNA elements contains a phylogenetic signal useful for inferring the evolutionary history of different groups of organisms. Here we test the reliability of this approach using the Hominidae family of primates, whose consensus phylogeny is well accepted. We used the software RepeatExplorer to identify the different repetitive DNA clusters and quantify their abundances. With these data, we performed phylogenetic analyses by maximum parsimony, including one, two or three individuals per species, technical replicates, and including or discarding two clusters of repetitive elements (i.e. a satellite DNA and an endogenous retrovirus) that generated random homoplasy, because they were abundant in Pan and Gorilla but almost absent in Homo and Pongo. The only phylogenetic tree congruent with the accepted topology for hominids, thus coinciding with that obtained from the mitogenomes of the same individuals, was the one built after filtering out the libraries for the two homoplasious clusters and using three individuals per species. Our results suggest some caution in the use of repeat abundance for phylogenetic studies, because some element abundances are homoplasious, which severely distorts the phylogenetic signal owing to their differential amplification among evolutionary lineages., M.M.P was supported by a FPU fellowship (FPU13/01553) from the Spanish Ministerio de Educación, Cultura y Deporte. F.J.R.R. and J.P.M.C. were supported by the Spanish Secretaría de Estado de Investigación, Desarrollo e Innovación (CGL2015- 70750-P), including FEDER funds, and F.J.R.R. was also supported by a Junta de Andalucía fellowship. S.D. was supported by a NERC studentship.

El saltamontes Locusta migratoria es el causante de una de las plagas más devastadoras sobre la agricultura: las plagas de langosta. Su genoma se caracteriza por tener uno de los sistemas de cromosomas B más ampliamente distribuidos de todos los estudiados en plantas y animales, puesto que se ha encontrado en poblaciones naturales de Asia, África, Australia y Europa. Con anterioridad al presente trabajo, se sabía que el cromosoma B de L. migratoria contiene genes para las histonas H3 y H4. La comparación de la secuencia de estos genes entre los cromosomas A y B ha sugerido que el cromosoma B probablemente derivó del autosoma 8, ya que éste es el único cromosoma A que muestra genes para las histonas H3 y H4. La divergencia en secuencia para estos genes entre cromosomas A y B proporcionó una primera estima de la edad mínima del cromosoma B (750.000 años). El objetivo general de esta tesis doctoral es profundizar en el conocimiento del origen y evolución de los cromosomas B de L. migratoria mediante el análisis de su contenido molecular, tanto de ADN repetitivo como de genes codificadores de proteínas, que puede ser indicativo de su posible origen y papel biológico., Tesis Univ. Granada. Departamento de Genética, Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía a través del Proyecto de Investigación de Excelencia P10-CVI-6649, Beca Predoctoral de Formación de Personal Docente e Investigador (FPDI) de la Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía

Poster presented at the 2nd International Congress of CiiEM: “Translational Research and Innovation in Human in health Sciences”. Egas Moniz, Caparica, 11-13 June 2017 Jellyfish has been proposed as a source in drug development to treat diseases such as arthritis and hypertension. Catostylus tagi, the sole European Catostylidae, is an edible Scyphozoa which occurs in summer at Tagus and Sado estuaries. Some aspects of its application in health sciences have already been studied. This assay aimed to investigate its sexual differentiation by morphological characteristics. Egas Moniz - Cooperativa de Ensino Superior CRL - Projects: EM-ZM 03: Preliminary studies on the capture and preservation conditions of a Portuguese medusa; EM-ZM-04: Studies on the utilization of Catostylus tagi in health sciences. N/A

Table of contents Oral Abstracts O1 Functionally distinct HMGB1 isoforms correlate with physiological processes in drug-induced SJS/TEN Daniel F. Carr, Wen-Hung Chung, Rosalind E. Jenkiins, Mas Chaponda, Gospel Nwikue, Elena M. Cornejo Castro, Daniel J. Antoine, Munir Pirmohamed O2 Hypersensitivity reactions to beta-lactams, does the t cell recognition pattern influence the clinical picture? Natascha Wuillemin, Dolores Dina, Klara K. Eriksson, Daniel Yerly O3 Specific binding characteristics of HLA alleles associated with nevirapine hypersensitivity Rebecca Pavlos, Elizabeth Mckinnin, David Ostrov, Bjoern Peters, Soren Buus, David Koelle, Abha Chopra, Craig Rive, Alec Redwood, Susana Restrepo, Austin Bracey, Jing Yuan, Silvana Gaudieri, Mary Carrington, David Haas, Simon Mallal, Elizabeth Phillips O4 Do we need to measure total ige for the interpretation of analytical results of ImmunoCAP dnd 3gAllergy specific IgE? Douwe De Boer, Paul Menheere, Chris Nieuwhof, Judith Bons O5 Neutrophil activation in systemic anaphylaxis: results from the multicentric NASA study Friederike Jonsson, Luc De Chaisemartin, Vanessa Granger, Caitlin Gillis, Aurelie Gouel, Catherine Neukirch, Fadia Dib, Pascale Roland Nicaise, Dan Longrois, Florence Tubach, Sylvie Martin, Pierre Bruhns, NASA Study Group O6 Purpuric drug eruptions due to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) for non-small-cell lung cancer (NSCLC): a clinic-pathological study of 32 cases Kai-Lung Chen, Shu-Ling Liao, Yi-Shuan Sheen, Yung-Tsu Cho, Che-Wen Yang, Jau-Yu Liau, Chia-Yu Chu Poster presentations: Poster Walk 1—Anaphylaxis (P01–P09) P1 Anaphylactic reactions during anaesthesia and the perioperative period Rita Aguiar, Anabela Lopes, Natália Fernandes, Leonor Viegas, M. A. Pereira-Barbosa P2 Anaphylaxis to chlorhexidine: is there a cross-reactivity to alexidine? Antonia Bünter, Nisha Gupta, Tatjana Pecaric Petkovic, Nicole Wirth, Werner J. Pichler, Oliver Hausmann P3 Cefotaxime-induced severe anaphylaxis in a neonate Mehtap Yazicioglu, Pinar G. Ozdemir, Gokce Ciplak, Ozkan Kaya P4 Clinical features and diagnosis of anaphylaxis resulting from exposure to chlorhexidine Peter John Cooke P5 Drug-induced anaphylaxis: five-year single-center survey Inês Mota, Ângela Gaspar, Filipe Benito-Garcia, Marta Chambel, Mário Morais-Almeida P6 Intraoperative severe anaphylactic reaction due to patent blue v dye Luis Marques, Eva Alcoceba, Silvia Lara P7 Kounis syndrome in the setting of anaphylaxis to diclofenac Leonor Carneiro-Leão, Carmen Botelho, Eunice Dias-Castro, Josefina Cernadas P8 Perioperative anaphylaxis audit: Royal Melbourne Hospital Katherine Nicholls, William Lay, Olivia Smith, Christine Collins, Gary Unglik, Kymble Spriggs, Priscilla Auyeung, Jeremy McComish, Jo A. Douglass P9 Recurrent peri-operative anaphylaxis: a perfect storm Jonny G. Peter, Paul Potter Poster Walk 2: DH regions and patient groups (P10–P19) P10 A rare presentation of amoxicillin allergy in a young child Fabrícia Carolino, Eunice Dias De Castro, Josefina R. Cernadas P11 Adverse drug reactions in children: antibiotics or virus? Ana Sofia Moreira, Carmo Abreu, Eva Gomes P12 Allergic reactions in invasive medical procedures Bárbara Kong Cardoso, Elza Tomaz, Sara Correia, Filipe Inácio P13 Antibiotic allergy in children: room for improvement Annabelle Arnold, Natasha Bear, Kristina Rueter, Grace Gong, Michael O’Sullivan, Saravanan Muthusamy, Valerie Noble, Michaela Lucas P14 Drug hypersensitivity reactions in children and results of diagnostic evaluation Neringa Buterleviciute, Odilija Rudzeviciene P15 Nonimmediate cutaneous drug reactions in children: are skin tests required? Ana Sofia Moreira, Carmo Abreu, Eva Gomes P16 Pediatric patients with a history of penicillin allergy and a positive penicillin skin test may not be at an increased risk for multiple drug allergies Sara May, Thanai Pongdee, Miguel Park P17 Proved hypersensitivity to drugs according data of Vilnius University Hospital Santariskiu Klinikos Linas Griguola, Arturas Vinikovas, Simona Kašinskaite, Violeta Kvedariene P18 Self-reported prevalence of drug hypersensitivity reactions among students in Celal Bayar University, Turkey Ayse Aktas, Suheyla Rahman, Huseyin Elbi, Beyhan Cengiz Ozyurt P19 Severe drug hypersensitivity reactions in pediatric age Ozlem Cavkaytar, Betul Karaatmaca, Pinar Gur Cetinkaya, Saliha Esenboga, Umit M. Sahiner, Bulent E. Sekerel, Ozge Soyer Poster Walk 3: Desensitisation (P20–P28) P20 A protocol for desensitisation to valaciclovir Celia Zubrinich, Bianca Tong, Mittal Patel, Michelle Giles, Robyn O’Hehir, Robert Puy P21 A rare case of desensitization to modafinil Josefina Cernadas, Luís Amaral, Fabrícia Carolino P22 A sixteen-day desensitization protocol in delayed type hypersensitivity reactions to oral drugs Semra Demir, Asli Gelincik, Muge Olgac, Raif Caskun, Derya Unal, Bahauddin Colakoglu, Suna Buyukozturk P23 Desensitization to intravenous etoposide using a 12 and a 13-step protocol. Two cases report Olga Vega Matute, Amalia Bernad, Gabriel Gastaminza, Roselle Madamba, Carlos Lacasa, M. J. Goikoetxea, Carmen D’Amelio, Jose Rifón, Nicolas Martínez, Marta Ferrer P24 Drug desensitisation in oncology: the experience of an immunoallergology department for 5 years Carmelita Ribeiro, Emília Faria, Cristina Frutuoso, Anabela Barros, Rosário Lebre, Alice Pego, Ana Todo Bom P25 Filgrastim anaphylaxis: a successful desensitization protocol Luis Amaral, Josefina Cernadas P26 Galsulfase hypersensitivity and desensitization of a mucopolysaccharidosis VI patient Luis Felipe Ensina, Carolina Aranda, Ines Camelo Nunes, Ana Maria Martins, Dirceu Solé P27 Rapid drug desensitization with biologicals: one-center experience with four biologicals Sevim Bavbek, Resat Kendirlinan, Pamir Çerçi, Seda Tutluer, Sadan Soyyigit, Zeynep Çelebi Sözener, Ömür Aydin, Reyhan Gümüsburun P28 Successful desensitization to a high dose of methotrexate in a delayed type hypersensitivity reaction Josefina Cernadas, Leonor Carneiro-Leão, Fabrícia Carolino, Marta Almeida Poster Walk 4: SJS (P29–P38) P29 Assessment of impact of infection on drug-induced severe cutaneous adverse reactions and rhabdomyolysis using the Japanese adverse drug event report database Kimie Sai, Takuya Imatoh, Ryosuke Nakamura, Chisato Fukazawa, Yasushi Hinomura, Yoshiro Saito P30 Characterization of erythema multiforme and severe cutaneous adverse reactions hospitalizations Bernardo Sousa-Pinto, Cláudia Correia, Lídia Gomes, Sara Gil-Mata, Luís Araújo, Luís Delgado P31 Effects of infection on incidence/severity of SJS/TEN and myopathy in Japanese cases analyzed by voluntary case reports Ryosuke Nakamura, Kimie Sai, Takuya Imatoh, Yoshimi Okamoto-Uchida, Koji Kajinami, Kayoko Matsunaga, Michiko Aihara, Yoshiro Saito P32 Efficacy of tumor necrosis factor—a antagonists in Stevens–Johnson syndrome and toxic epidermal necrolysis: a randomized controlled trial and immunosuppressive effects evaluation Chuang-Wei Wang, Shih-Chi Su, Shuen-Iu Hung, Hsin-Chun Ho, Chih-Hsun Yang, Wen-Hung Chung P33 Evolution of drug causality in Stevens–Johnson syndrome and toxic epidermal necrolysis in Europe: analysis of 10 years RegiSCAR-Study Maren Paulmann, Ariane Dunant, Maja Mockenhaupt, Peggy Sekula, Martin Schumacher, Sylvia Kardaun, Luigi Naldi, Teresa Bellón, Daniel Creamer, Cynthia Haddad, Bruno Sassolas, Bénédicte Lebrun-Vignes, Laurence Valeyrie-Allanore, Jean-Claude Roujeau P34 Long-term sequelae in patients with Stevens–Johnson syndrome and toxic epidermal necrolysis: a 5-year analysis Maren Paulmann, Carmen Kremmler, Peggy Sekula, Laurence Valeyrie-Allanore, Luigi Naldi, Sylvia Kardaun, Maja Mockenhaupt P35 Major emotional complications and decreased health related quality of life among survivors of Stevens–Johnson syndrome and toxic epidermal necrolysis Roni P. Dodiuk-Gad, Cristina Olteanu, Anthony Feinstein, Rena Hashimoto, Raed Alhusayen, Sonia Whyte-Croasdaile, Yaron Finkelstein, Marjorie Burnett, Shachar Sade, Robert Cartotto, Marc Jeschke, Neil H. Shear P36 Retrospective analysis of Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese patients: treatment and outcome Naoko Takamura, Yumiko Yamane, Setsuko Matsukura, Kazuko Nakamura, Yuko Watanabe, Yukie Yamaguchi, Takeshi Kambara, Zenro Ikezawa, Michiko Aihara P37 Severe physical complications among survivors of Stevens–Johnson syndrome and toxic epidermal necrolysis Roni P. Dodiuk-Gad, Cristina Olteanu, Rena Hashimoto, Hall Chew, Raed Alhusayen, Sonia Whyte-Croasdaile, Yaron Finkelstein, Marjorie Burnett, Shachar Sade, Robert Cartotto, Marc Jeschke, Neil H. Shear P38 Stevens–Johnson syndrome/toxic epidermal necrolysis combined with haemophagocytic lymphohistiocytosis: a case report Brittany Knezevic, Una Nic Ionmhain, Allison Barraclough, Michaela Lucas, Matthew Anstey Poster Walk 5: Other organs/unexpected immune reactions (P39–P47) P39 A case report of patient with anti-tuberculosis drug-related severe liver failure Toru Usui, Xiaoli Meng, John Farrell, Paul Whitaker, John Watson, Neil French, Kevin Park, Dean Naisbitt P40 Acute interstitial nephritis induced by ibuprofen Ana Castro Neves, Susana Cadinha, Ana Moreira, J. P. Moreira Da Silva P41 Cetuximab induced acneiform rash—two case reports Daniela Ledic Drvar, Sandra Jerkovic Gulin, Suzana Ljubojevic Hadzavdic, Romana Ceovic P42 Enteropathy associated with losartan Ana Montoro De Francisco, Talía De Vicente Jiménez, Amelia García Luque, Natalia Rosado David, José Mª Mateos Galván P43 Granuloma annulare after therapy with canakinumab Razvigor Darlenski P44 Hypersensitivity eosinophilic myocarditis or acute coronary syndrome? Case report Dario Gulin, Jozica Sikic, Jasna Cerkez Habek, Sandra Jerkovic Gulin, Edvard Galic P45 Piperacillin-induced immune haemolytic anaemia: a severe and frequent complication of antibiotic treatment in patients with cystic fibrosis Philip Specht, Doris Staab, Beate Mayer, Jobst Roehmel P46 Progesterone triggered pemphigus foliaceus: case report Sandra Jerkovic Gulin, Caius Solovan, Anca Chiriac P47 Ramipril: triggered generalized pustular psoriasis Paola Djurinec, Kresimir Kostovic, Mirna Bradamante, Sandra Jerkovic Gulin, Romana Ceovic Poster Walk 6: NSAIDs (P48–P56) P48 Aspirin desensitization in cardiovascular disease—Portuguese experience Jose Pedro Almeida, Joana Caiado, Elisa Pedro, Pedro Canas Da Silva, Manuel Pereira Barbosa P49 Asthma and/or rhinitis to NSAIDs with good tolerance to ASA Gador Bogas, Natalia Blanca-López, Diana Pérez-Alzate, Inmaculada Doña, José Augusto Agúndez, Elena García-Martín, José Antonio Cornejo-García, Cristobalina Mayorga, María José Torres, Gabriela Canto, Miguel Blanca P50 Clinical characteristics of 196 patients with non-steroidal anti-inflammatory drug (NSAIDs) hypersensitivity Sengül Aksakal, Aytül Zerrin Sin, Zeynep Peker Koç, Fatma Düsünür Günsen, Ömür Ardeniz, Emine Nihal Mete Gökmen, Okan Gülbahar, Ali Kokuludag P51 Development of immediate hypersensitivity to several NSAIDs maintaining good tolerance to ASA Natalia Pérez-Sánchez, Natalia Blanca-López, Diana Pérez-Alzate, Gador Bogas, Inmaculada Doña, María Salas, María José Torres, Miguel Blanca, Gabriela Canto P52 Diagnosis of hypersensitivity reactions to paracetamol in a large series of cases Inmaculada Doña, Maria Salas, Francisca Gomez, Natalia Blanca-Lopez, Diana Perez-Alzate, Gador Bogas, Esther Barrionuevo, Maria Jose Torres, Inmaculada Andreu, Miguel Ángel Miranda, Gabriela Canto, Miguel Blanca P53 Hypersensitivity to paracetamol according to the new classification of hypersensitivity to NSAIDs Gabija Didžiokaite, Olesia Gaidej, Simona Kašinskaite, Violeta Kvedariene P54 Ibuprofen and other aryl propionic derivates can induce immediate selective hypersensitivity responses Diana Perez-Alzate, Natalia Blanca-López, Maria Isabel Garcimartin, Inmaculada Doña, Maria Luisa Somoza, Cristobalina Mayorga, Maria Jose Torres, Gador Bojas, Jose Antonio Cornejo-Garcia, Maria Gabriela Canto, Miguel Blanca P55 Subjects developing immediate responses to several NSAIDs can be selective with good tolerance to ASA Natalia Blanca-Lopez, Diana Pérez-Alzate, Francisco Javier Ruano Perez, Inmaculada Doña, Maria Luisa Somoza, Inmaculada Andreu, Miguel Angel Miranda, Cristobalina Mayorga, Maria Jose Torres, Jose Antonio Cornejo-Garcia, Miguel Blanca, Maria Gabriela Canto P56 Utility of low-dose oral aspirin challenges for diagnosis of aspirin exacerbated respiratory disease Elina Jerschow, Teresa Pelletier, Zhen Ren, Golda Hudes, Marek Sanak, Esperanza Morales, Victor Schuster, Simon D. Spivack, David Rosenstreich Poster Walk 7: NSAID 2 (P57–P65) P57 Alternate regulation of cyclooxygenase-2 (COX-2) MRNA expression may predispose patients to aspirin-induced exacerbations Renato Erzen, Mira Silar, Nissera Bajrovic, Matija Rijavec, Mihaela Zidarn, Peter Korosec P58 Anaphylaxis to diclofenac: what about the underlying mechanism? Leonor Carneiro-Leão, Fabrícia Carolino, Luís Amaral, Carmen Botelho, Eunice Dias-Castro, Josefina Cernadas P59 COX-2 inhibitors: are they always a safe alternative in hypersensitivity to nonsteroidal anti-inflammatory drugs? Luis Amaral, Fabricia Carolino, Eunice Castro, Josefina Cernadas P60 Management of patients with history of NSAIDs reactions prior to coronary angioplasty Mona Al-Ahmad, Tito Rodriguez P61 Oral drug challenge with non-steroidal anti-inflammatory drug under spirometric control: clinical series of 110 patients João Pedro Azevedo, Emília Faria, Beatriz Tavares, Frederico Regateiro, Ana Todo-Bom P62 Prevalence and incidence of analgesic hypersensitivity reactions in Colombia Pablo Andrés Miranda, Bautista De La Cruz Hoyos P63 Recent endoscopic sinus surgery lessens reactions during aspirin challenge in patients with aspirin exacerbated respiratory disease Teresa Pelletier, Waleed Abuzeid, Nadeem Akbar, Marc Gibber, Marvin Fried, Weiguo Han, Taha Keskin, Robert Tamayev, Golda Hudes, Simon D. Spivack, David Rosenstreich, Elina Jerschow P64 Safe use of imidazole salycilate in a case of multiple NSAIDs induced urticaria-angioedema Elisa Boni, Marina Russello, Marina Mauro P65 Selective hypersensitivity reactions to ibuprofen—seven years experience Marta Ferreira Neto Poster Walk 8: Epidemiological methods (P66–P72) P66 Allopurinol hypersensitivity: a 7-year review Lise Brosseron, Daniela Malheiro, Susana Cadinha, Patrícia Barreira, J. P. Moreira Da Silva P67 Antibiotic allergy labelling is associated with increased hospital readmission rates in Australia Brittany Knezevic, Dustin Sprigg, Michelle Trevenen, Jason Seet, Jason Trubiano, William Smith, Yogesh Jeelall, Sandra Vale, Richard Loh, Andrew Mclean-Tooke, Michaela Lucas P68 Experts’ opinions on severe cutaneous adverse drug reactions-report of a survey from the 9th international congress on cutaneous adverse drug reactions 2015 Roni P. Dodiuk-Gad, Cristina Olteanu, Wen-Hung Chung, Neil H. Shear P69 HLA-A*31-positive AGEP with carbamazepine use and other severe cutaneous adverse drug reactions (SCARs) detected by electronic medical records screening Sabine Müller, Ursula Amstutz, Lukas Jörg, Nikhil Yawalkar, Stephan Krähenbühl P70 Patients with suspected drug allergy: a specific psychological profile? Eunice Dias-Castro, Ana Leblanc, Laura Ribeiro, Josefina R. Cernadas P71 Use of an electronic device and a computerized mathematic algorithm to detect the allergic drug reactions through the analysis of heart rate variability Arantza Vega, Raquel Gutierrez Rivas, Ana Alonso, Juan Maria Beitia, Belén Mateo, Remedios Cárdenas, Juan Jesus Garcia-Dominguez P72 Variation in ERAP influences risk for HLA-B*57:01 positive abacavir hypersensitivity Rebecca Pavlos, Kaija Strautins, Ian James, Simon Mallal, Alec Redwood, Elizabeth Phillips Poster Walk 9: DRESS/AGEP (P73–P81) P73 A clinical case of DRESS syndrome in a child after administration of amoxicillin-clavulanic acid Rita Aguiar, Anabela Lopes, Ana Neves, Maria Do Céu Machado, M. A. Pereira-Barbosa P74 Acute generalized exanthematous pustulosis (AGEP) induced by mesalazine, reliable and oftenly used drug to treat inflammatory bowel disease Ceyda Tunakan Dalgiç, Emine Nihal Mete Gökmen, Fatma Düsünür Günsen, Gökten Bulut, Fatma Ömür Ardeniz, Okan Gülbahar, Ali Kokuludag, Aytül Zerrin Sin P75 Changes of blood plasmacytoid dendritic cells, myeloid dendritic cells, and basophils during the acute stage of drug reaction with eosinophilia and systemic symptoms (DRESS) and other drug eruptions Shao-Hsuan Hsu, Yung-Tsu Cho, Che-Wen Yang, Kai-Lung Chen, Chia-Yu Chu P76 Characterization of isoniazid/rifampicin-specific t-cell responses in patients with DRESS syndrome Young-Min Ye, Gyu-Young Hur, Hae-Sim Park, Seung-Hyun Kim P77 DRESS syndrome secondary to sulfasalazine with delayed TEN: a case presentation Syed Ali, Michaela Lucas, Peter N. Hollingsworth, Andrew P. C. Mclean-Tooke P78 Drug rash with eosinophilia and systemic symptoms (DRESS) features according to the culprit drug Zohra Chadly, Nadia Ben Fredj, Karim Aouam, Haifa Ben Romdhane, Naceur A. Boughattas, Amel Chaabane P79 Drug reaction with eosinophilia and systemic symptoms induced by allopurinol: not always easy to diagnose Marina Lluncor Salazar, Beatriz Pola, Ana Fiandor, Teresa Bellón, Elena Ramírez, Javier Domínguez Ortega, Santiago Quirce, Rosario Cabañas P80 Drug reaction with eosinophilia and systemic symptoms syndrome induced by two drugs simultaneously: a case report Krasimira Baynova, Marina Labella, Manuel Prados P81 The drug reaction with eosinophilia and systemic symptoms (DRESS) induced by the second-line antituberculosis drugs and Epstein–Barr virus infection Agne Ramonaite, Ieva Bajoriuniene, Brigita Sitkauskiene, Raimundas Sakalauskas Poster Walk 10: Miscellaneous drug hypersensitivity (P82–P91) P82 A case of cycloserine-induced lichenoid drug eruption confirmed with a lymphocatye transformation test Jae-Woo Kwon, Shinyoung Park P83 Allergic reaction to topical eye drops: 5 years’ retrospective study in a drug allergy unit Diana Silva, Leonor Carneiro Leão, Fabricia Carolino, Eunice Castro, Josefina Cernadas P84 Allergy to heparins Diana Perez-Alzate, Natalia Blanca-López, Maria Luisa Somoza Alvarez, Maria Garcimartin, Maria Vazquez De La Torre, Francisco Javier Ruano Pérez, Elisa Haroun, Gabriela Canto Diez P85 Allopurinol-induced adverse drug reactions Katinka Ónodi-Nagy, Ágnes Kinyó, Lajos Kemény, Zsuzsanna Bata-Csörgo P86 Analysis of a population with immediate hypersensitivity to corticosteroids: an 11 year review Joana Sofia Pita, Emília Faria, Rosa Anita Fernandes, Ana Moura, Nuno Sousa, Carmelita Ribeiro, Carlos Loureiro, Ana Todo Bom P87 Anaphylaxis against mivacurium in a 12-months old boy at first-time exposure Wolfgang Pfützner P88 Antihistamine-exacerbated chronic spontaneous urticaria: a paradox? Nadine Marrouche, Clive Grattan P89 Anti-osteoporotic agents-induced cutaneous adverse drug reactions in Asians Yu-En Chen, Chun-Bing Chen, Wen-Hung Chung, Yu-Ping Hsiao, Chia-Yu Chu P90 Diagnosis of allergic reactions to eye drops Maria Vazquez De La Torre, Natalia Blanca-Lopez, Diana Perez-Alzate, Maria Isabel Garcimartin, Francisco Javier Ruano, Maria Luisa Somoza, Elisa Haroun, Gabriela Canto P91 Diagnostic approach in suspected hypersensitivity reactions to corticosteroids Fabrícia Carolino, Eunice Dias De Castro, Josefina R. Cernadas

Este libro es una introducción al diseño metodológico de programas en la que se incide en el uso de los tipos de datos que dichos programas manipulan para representar el dominio de los problemas que resuelven.En concreto, la aproximación al diseño de programas seguida en este libro es la denominada Programación Orientada a Objetos,usa Java como lenguaje vehicular, incluye los tópicos habituales de un curso de programación a pequeña escala y hace de la eficiencia el criterio último de diseño de programas y tipos de datos.Aunque este libro va dirigido principalmente a estudiantes de primer curso del nuevo Grado en Informática,también puede resultar de utilidad en otros estudios universitarios o, incluso,en aquellos ámbitos académicos e industriales donde una buena fundamentación en la construcción y análisis de programas es necesaria

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El trabajo que se presenta constituye un ambicioso estudio teórico-práctico sobre las posibilidades que ofrece la práctica teatral para el aprendizaje de las lenguas extranjeras, más concretamente la lengua francesa, en el ámbito de la Educación Secundaria. En detalle, la estructura de la tesis contaría con unas páginas de introducción o preámbulo, con la Primera Parte, de fundamentación teórica, capítulo 1, en donde ofrecemos los fundamentos metodológicos de nuestra investigación, entre los que destaca el método de investigación-acción, que nos permite dar carta de naturaleza y legitimidad al proceso de experimentación emprendido y sienta las bases para la redacción de este trabajo. Los fundamentos lingüísticos (capítulo 2) incluyen tanto la delimitación de los conceptos de lengua y lenguaje, como la toma en consideración del aspecto paraverbal y no verbal de la comunicación humana, así como los elementos socioculturales asociados a cada lengua. En el capítulo 3, sobre los fundamentos didácticos de la enseñanza de lenguas extranjeras, se describen brevemente los métodos de enseñanza de lenguas y se propone su mejora y/o reintroducción en las aulas a través de la utilización de técnicas y elementos propios del teatro. valorando finalmente cómo la práctica teatral encuentra su hueco de pleno derecho en el enfoque accional o por tareas y puede evolucionar, en conclusión, hacia una metodología dramática. La segunda parte, en su capítulo 1, aborda la creación de un proyecto dramático, así como las etapas de desarrollo del mismo, en el marco de un proyecto colaborativo. Aquí se explican las tres vertientes del texto dramático y que fueron tenidas en cuenta durante la confección del mismo por los estudiantes: el propio texto escrito, su verbalización y no-verbalización a través del gesto y la creación de los elementos accesorios. En esta segunda parte, igualmente, se muestra un repertorio documentado con una completa selección de actividades dramáticas realizadas durante estos años de investigación, desde formas dramáticas sencillas hasta representaciones complejas. La culturalidad asociada a la práctica dramática también se trata en este capítulo, mientras que en el capítulo 2 se proponen varias fuentes de inspiración para la creación de la obra teatral en FLE: formas teatrales medievales francesas, drama francófono y dramaturgos franceses contemporáneos. En el capítulo 3 ofrecemos, así, una selección de textos pertenecientes a los ámbitos anteriormente expuestos y la forma en que han sido analizados y llevados a escena por parte de nuestro alumnado. La tercera parte es un extenso desarrollo de la valoración de los resultados de la experiencia, preguntándonos si es posible oficializar una metodología teatral, a la vista de los resultados obtenidos en distintos apartados y evaluados según diferentes parámetros. Junto a ello, sugerimos la experiencia de los intercambios lingüísticos con centros franceses como ventaja añadida o continuación del proceso. Tras las conclusiones, exponemos la Bibliografía utilizada y tenida en consideración que abarca todos y cada uno de los aspectos tratados en esta tesis. Lingüística, Didáctica, Literatura, Teatro, Pedagogía, Psicología, Antropología y cultura se entrelazan a lo largo de este estudio y las obras reflejadas en este apartado así lo manifiestan., Tesis Univ. Granada. Programa Oficial de Doctorado en: Lenguas, Textos y Contextos

Mestrado em Economia Monetária e Financeira The aim of this research is to assess how the unconventional monetary policy instruments used by the Federal Reserve impacted on the North American Stock Market from the period between January 2009 and September 2012. We present the economic theory concerning the transmission mechanism of the monetary policy to the Economy, the channels through which this transmission becomes effective and, in particular, the functioning of the stock price transmission channel. We also present the economic theory on how unconventional monetary policy instruments, the Quantitative Easing programs, impact on assets and particularly on the stock prices. In the spirit of the Arbitrage Pricing Theory (APT) we develop a GARCH model in order to assess which macroeconomic, financial and conventional and unconventional monetary variables impacted on the evolution of the North-American Stock market in the period referred above. We observe that almost all of the variables chosen in this study tend to impact on the equity prices in the long run, but they have no impact in a period of financial distress such as the one between January 2009 and September 2012. We also found no evidence that the Quantitative Easing programs launched by the Federal Reserve after January 2009 had a permanent and direct impact on the recovery of the North American Markets until September 2012. O presente trabalho tem como objectivo avaliar se a política monetária não convencional, levada a cabo pela Reserva Federal Norte-Americana (FED) entre Janeiro de 2009 e Setembro de 2012, teve impacto na recuperação do Mercado Accionista dos Estados Unidos da América no referido período. Em primeiro lugar, começamos por apresentar a teoria económica referente à transmissão da política monetária para os restantes agregados macroeconómicos, os canais através dos quais essa transmissão se processa e, em particular, através do canal do mercado accionista. Apresentamos, também, a teoria relativa ao modo como os programas de Quantitative Easing afectam os diversos activos financeiros e, em especial, a evolução do mercado accionista. Em seguida, e no espírito da Arbitrage Pricing Theory (APT), desenvolvemos um modelo GARCH que nos permite avaliar quais as variáveis macroeconómicas, financeiras e de política monetária convencional e não convencional, que influenciaram a evolução do mercado accionista norte-americano no período supra referido. Verificamos que a quase totalidade das variáveis consideradas têm um impacto estatisticamente significativo no mercado accionista quando consideramos períodos temporais longos, mas aparentam não ter impacto em períodos de instabilidade financeira, como os vividos entre Janeiro de 2009 e Setembro de 2012. De referir, também, que não encontramos evidência empírica de que os programas de Quantitative Easing, lançados pela FED após Janeiro de 2009, tivessem tido um impacto directo e permanente na recuperação do mercado accionista norte-americano.

Resumen tomado de la publicación Se analiza desde la perspectiva social-cognitiva de las metas de logro las principales variables predictoras del flow disposicional, incluyendo tanto a las orientaciones disposicionales como a la percepción del clima motivacional en el aula, así como la valoración de la Educación Física (E.F.), que realizan los estudiantes de la signatura. Además se analizan las correlaciones entre las diferentes variables. El estudio se llevo acabo con una muestra de 300 estudiantes de Educación Física, de 14 a 18 años de edad. Se utilizo un análisis de regresión y un análisis de correlaciones. Los resultados obtenidos muestran que los predictores significativos del flow son las orientaciones disposicionales y la valoración que den los alumnos a la asignatura de Educación Física. El clima motivacional solo es predictor del flow cuando se le considera como única posible variable predictora. Madrid Biblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín, 5 - 3 Planta; 28014 Madrid; Tel. +34917748000; biblioteca@mecd.es ESP

Dentro de la interpretación musical, el músico suele tener grandes preocupaciones, las cuales suelen estar relacionadas entre sí. Dentro de esta investigación he podido ver como músicos de gran nivel profesional se han realizado las siguientes preguntas: ¿cómo puedo mejorar el sonido?, ¿cómo afecta la posición de la boca o la sílaba que pronuncio en la articulación?, ¿qué sordina en concreto es más adecuada? En este trabajo, hemos realizado un estudio físico de diferentes trombones de varas, los cuales tres de ellos, son utilizados actualmente por muchos de nuestros estudiantes de música, vamos a realizar con ellos diferentes pruebas, con ataques cortos y diferentes arpegios en dos gamas sonoras forte y piano. Este proyecto trata de hacer un estudio objetivo de diferentes trombones pero, sin ánimo de afirmar, cuál de ellos es mejor. En este estudio vamos a utilizar las siguientes marcas de instrumentos: Stradivarius Bach, Conn, Yamaha, Consolat del mar. Se trata por tanto, de realizar una investigación sobre la frecuencia, los matices dinámicos y los armónicos resultantes de estos.

The purple dye murex, Bolinus brandaris (Linnaeus, 1758), is a muricid gastropod common throughout the Mediterranean and along the Moroccan and Portuguese Atlantic coasts. In the present study, we confirmed the diploid chromosome number of 2n = 70 for this species, and established for the first time the karyotype, which comprised 12 metacentric, 15 submetacentric and eight subtelocentric chromosome pairs. To facilitate cytotaxonomic comparisons, we carried out a comparative karyological analysis through multidimensional scaling between B. brandaris and three other 2n = 70 muricid species (Hexaplex trunculus, Ocenebra erinaceus, and Stramonita haemastoma) for which chromosomal measurements have been previously published. The interpretation of the ideograms and the statistical analysis highlighted the closest similarity of B. brandaris and H. trunculus compared to S. haemastoma and O. erinaceus. Indeed, B. brandaris and H. trunculus showed the smallest dissimilarities both for relative length and arm ratio, with O. erinaceus presenting intermediate values, whereas the highest dissimilarities were found between H. trunculus and S. haemastoma for both data. The karyotypes of B. brandaris and H. trunculus (subfamily Muricinae) presented the highest proportions of metacentric chromosomes compared to the other two muricids analysed, suggesting that those karyotypes could be considered primitive within the 2n = 70 Muricidae studied so far. (C) 2009 The Linnean Society of London, Biological Journal of the Linnean Society, 2009, 96, 185-193. Fundacao para a Ciencia e Tecnologia (FCT) [SFRH/BPD/18961/2004, SFRH/BPD/26348/2006]; PROMAR; Tecnologias de Producao Aquicola [22-05-01-FDR-0009] info:eu-repo/semantics/publishedVersion

En el siguiente trabajo se realiza un análisis de los procesos motivacionales que se desarrollan en las clases de Educación Física. Tomando como fundamento la Teoría de las Metas de Logro (Nicholls, 1989; Ames, 1992), se explican cada uno de los diferentes constructos que forman dicha teoría (Orientaciones, Climas e Implicaciones Motivacionales) y la relación entre ellos. Asimismo, se exponen diversas investigaciones que han demostrado estas relaciones, y como, el desarrollo de un clima implicante a la tarea, puede mejorar y hacer más adaptativos los patrones conductuales de los alumnos. Por último, se hace una propuesta metodológica para desarrollar un clima implicante a la tarea por parte del profesorado de Educación Física, con los beneficios que ello reporta.

Resumen tomado de la publicación Se presenta un trabajo en el que se realiza un análisis de los procesos motivacionales que se desarrollan en las clases de Educación Física. Tomando como fundamento la Teoría de las Metas de Logro, se explican cada uno de los diferentes constructos que forman dicha teoría (Orientaciones, Climas e Implicaciones Motivacionales) y la relación entre ellos. Asimismo, se exponen diversas investigaciones que han demostrado estas relaciones, y como, el desarrollo de un clima implicante a la tarea, puede mejorar y hacer más adaptativos los patrones conductuales de los alumnos. Por último, se hace una propuesta metodológica para desarrollar un clima implicante a la tarea por parte del profesorado de Educación Física, con los beneficios que ello reporta. Cataluña Universidad Pública de Navarra. Biblioteca; Campus de Arrosadía; 31006 Pamplona; Tel. +34948169060; Fax +34948169069; bupna@unavarra.es ESP

Al treball següent es fa una anàlisi dels processos motivacionals que es desenvolupen a les classes d’Educació Física. Prenent com a fonament la Teoria de les Fites d’Assoliment (Nicholls, 1989; Ames, 1992), s’expliquen cada un dels diferents constructes que formen la teoria esmentada (Orientacions, Climes i Implicacions Motivacionals) i la relació entre ells. També s’hi exposen diverses investigacions que han demostrat aquestes relacions, i de quina manera el desenvolupament d’un clima que implica vers la tasca pot millorar i fer més adaptatius els patrons conductuals dels alumnes. Finalment, es fa una proposta metodològica per desenvolupar un clima que impliqui vers la tasca per part del professorat d’Educació Física, amb els beneficis que això reporta.

Se ha secuenciado un fragmento de un gen de la a-tubulina, amplificado por PCR, del cil iado hipotrico Histriculus cavicola. Este fragmento, de 1182 pb, contiene un codón de terminación (UAA) en la fase de lectura, que en otros ciliados hipotricos codifica la glutamina. La comparación de los genes de la cx-tubulina de varias clases de ciliados ha mostrado que algunas posiciones de aminoácidos pueden servir para distingu i r estos grupos taxonóm icos. An α-tubulin gene fragment amplified by PCR from the hypotrichous ciliate Histriculus cavicola has been sequenced. This fragment, 1182 bp long, contains an in-frame "stop" codon (UAA), which i n other hypotrichous species codes for a glutamine residue. The comparison of the a-tubu li n genes from severa!ciliates classes have revealed amino acid positions which could serve to distinguish these taxonomic groups.

An infection caused by a Perkinsus -like parasite has been observed in Ruditapes decussatus from Portugal (Comps and Chagot, 1987). Following a pathological study carried out on clams affected by mortalities in the Algarve area, this parasite was found again, inducing a reaction process in the host. Histological examination reveals the parasite in the connective tissue of different organs. The adjoining tissues, particularly the epithelia, are not affected.

LXVIII, [4] p., [11] h. pleg. ; 4o., Sign.: A-H4, I2, [calderón]2

Mestrado em Engenharia Agronómica - Produção Animal - Instituto Superior de Agronomia / Faculdade de Medicina Veterinária A cultura de moluscos bivalves (moluscicultura) é uma atividade com elevada expressão na aquacultura portuguesa, representando 55% da produção total e a produção de amêijoas representa cerca de 24% do total produzido. A amêijoa-boa, Ruditapes decussatus, é a espécie de maior importância económica, mas, nos últimos anos, a sua produção diminuiu associada a diversos fatores, como a sobre-exploração e doenças como a Perkinsiose. Para enfrentar a diminuição de R. decussatus, esta foi substituída pela amêijoa-japonesa, Ruditapes philippinarum, que aparentava ter maior resistência a doenças e maiores taxas de crescimento. Apesar da rápida expansão desta espécie em águas portuguesas, a amêijoa nativa continua a ser comercialmente mais importante e apreciada do que a amêijoa-japonesa pela sua qualidade. O objetivo deste estudo foi avaliar os métodos de diagnóstico da Perkinsiose em duas espécies de amêijoas de locais distintos. Utilizaram-se como métodos o teste RFTM (teste referência) e a histopatologia (método complementar). As amostras foram coletadas em Outubro de 2017 e Abril de 2018 em 6 locais diferentes, com n=50 para cada local (exceto no Estuário do Tejo (2017) com n=47) correspondendo a um total de 297 espécimes examinados. Os resultados mostraram que a amêijoa-boa tinha maior prevalência da doença, principalmente a produzida em Olhão. A amêijoa-japonesa também teve casos positivos, embora com menor nível de infeção. Este estudo sugeriu que para diagnosticar a Perkinsiose, o teste RFTM é eficaz, menos dispendioso e mais rápido. Mas deve ser complementado por análises histopatológicas especialmente em animais com baixa infeção. Tendo em conta as condições ambientais nos diferentes locais, é notório que o stress ambiental causado por altas salinidades e temperaturas da água, a baixa concentração de oxigénio nos sedimentos, altas densidades e stress fisiológico devido à época de desova contribuem para aumentar a prevalência e propagação da doença N/A