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1. Plasma heavy metal levels correlate with deregulated gene expression of detoxifying enzymes in osteoporotic patients

Author: Visconti, Vv, Gasperini, B, Greggi, C, Battistini, B, Messina, A, Renzi, M, Bakhtafrouz, K, Iundusi, R, Botta, A, Palombi, L, and Tarantino, U
Subjects: Settore MED/33
Published: 2023

2. Reporting Marine Microplastics Data: the Need for a Standardized Protocol

Author: Pauna, Vh, Buonocore, E, Renzi, M, Russo, Gf, Franzese, Pp, Pauna, Vh, Buonocore, E, Renzi, M, Russo, Gf, and Franzese, Pp
Subjects: Marine litter, Ecology, Strategy and Management, Ecological Modeling, Microplastics, Microplastic, General reporting protocol, Management, Monitoring, Policy and Law, Urban Studies, Accounting, Plastic pollution, Marine ecosystem, Marine ecosystems
Abstract: Marine microplastics have become an issue of great concern at the global level. The attention towards the issue of marine microplastics, highly recognized by international policy and scientific research, has increased considerably over the last decades. At the European level, several initiatives have been promoted addressing the reduction of plastic pollution as a high priority target, among which the Marine Strategy Framework Objective (D10) and the European Strategy for Plastics in a Circular Economy. In addition, researchers have explored many strategies to optimize the detection and monitoring of microplastics in sediments, seawater, and organisms and to effectively demonstrate their potential ecological harm. However, since pollution dynamics, the functioning of natural ecosystems, and their relationships are very complex, there still lacks a comprehensive understanding of the impacts of microplastics on marine ecosystems. This lack of knowledge may impact the effectiveness of decision-making processes in terms of plastic reduction and waste management. In this study, we present the results of a literature review which focuses on particularly impactful marine microplastic methodological and analytical articles from 2004 to 2017 to identify possible gaps or inconsistencies in the reported data. Based on this review, a framework for a general reporting protocol (GRP) is outlined to encourage increased collaborative research efforts to harmonize the reporting of microplastics data in scientific studies. The proposed GRP outline could be useful in addressing data needs for effective ecological risk assessment. (C) 2022 L&H Scientific Publishing, LLC. All rights reserved.
Published: 2022

3. Mediterranean rocky reefs in the Anthropocene: Present status and future concerns

Author: Bevilacqua, S., Airoldi, L., Ballesteros, E., Benedetti-Cecchi, L., Boero, F., Bulleri, F., Cebrian, E., Cerrano, C., Claudet, J., Colloca, F., Coppari, M., Di Franco, A., Fraschetti, S., Garrabou, J., Guarnieri, G., Guerranti, C., Guidetti, P., Halpern, B. S., Katsanevakis, S., Mangano, M. C., Micheli, F., Milazzo, M., Pusceddu, A., Renzi, M., Rilov, G., Sara, G., Terlizzi, A., Bevilacqua, S., Airoldi, L., Ballesteros, E., Benedetti-Cecchi, L., Boero, F., Bulleri, F., Cebrian, E., Cerrano, C., Claudet, J., Colloca, F., Coppari, M., Di Franco, A., Fraschetti, S., Garrabou, J., Guarnieri, G., Guerranti, C., Guidetti, P., Halpern, B. S., Katsanevakis, S., Mangano, M. C., Micheli, F., Milazzo, M., Pusceddu, A., Renzi, M., Rilov, G., Sara, G., Terlizzi, A., Bevilacqua S., Airoldi L., Ballesteros E., Benedetti-Cecchi L., Boero F., Bulleri F., Cebrian E., Cerrano C., Claudet J., Colloca F., Coppari M., Di Franco A., Fraschetti S., Garrabou J., Guarnieri G., Guerranti C., Guidetti P., Halpern B.S., Katsanevakis S., Mangano M.C., Micheli F., Milazzo M., Pusceddu A., Renzi M., Rilov G., Sara G., and Terlizzi A.
Subjects: Conservation of Natural Resources, Bioconstruction, Fish assemblage, Coral Reefs, Algal forests, Bioconstructions, Coastal ecosystems, Conservation, Fish assemblages, Global change, Marine biodiversity, Climate Change, Biodiversity, Algal forest, Mediterranean Sea, Humans, Coastal ecosystem, Ecosystem
Abstract: Global change is striking harder and faster in the Mediterranean Sea than elsewhere, where high levels of human pressure and proneness to climate change interact in modifying the structure and disrupting regulative mechanisms of marine ecosystems. Rocky reefs are particularly exposed to such environmental changes with ongoing trends of degradation being impressive. Due to the variety of habitat types and associated marine biodiversity, rocky reefs are critical for the functioning of marine ecosystems, and their decline could profoundly affect the provision of essential goods and services which human populations in coastal areas rely upon. Here, we provide an up-to-date overview of the status of rocky reefs, trends in human-driven changes undermining their integrity, and current and upcoming management and conservation strategies, attempting a projection on what could be the future of this essential component of Mediterranean marine ecosystems.
Published: 2021

4. Long-term exposure to air pollution and mortality in a Danish nationwide administrative cohort study: Beyond mortality from cardiopulmonary disease and lung cancer

Author: So, R. Andersen, Z.J. Chen, J. Stafoggia, M. de Hoogh, K. Katsouyanni, K. Vienneau, D. Rodopoulou, S. Samoli, E. Lim, Y.-H. Jørgensen, J.T. Amini, H. Cole-Hunter, T. Mahmood Taghavi Shahri, S. Maric, M. Bergmann, M. Liu, S. Azam, S. Loft, S. Westendorp, R.G.J. Mortensen, L.H. Bauwelinck, M. Klompmaker, J.O. Atkinson, R. Janssen, N.A.H. Oftedal, B. Renzi, M. Forastiere, F. Strak, M. Thygesen, L.C. Brunekreef, B. Hoek, G. Mehta, A.J.
Abstract: Background: The association between long-term exposure to air pollution and mortality from cardiorespiratory diseases is well established, yet the evidence for other diseases remains limited. Objectives: To examine the associations of long-term exposure to air pollution with mortality from diabetes, dementia, psychiatric disorders, chronic kidney disease (CKD), asthma, acute lower respiratory infection (ALRI), as well as mortality from all-natural and cardiorespiratory causes in the Danish nationwide administrative cohort. Methods: We followed all residents aged ≥ 30 years (3,083,227) in Denmark from 1 January 2000 until 31 December 2017. Annual mean concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), and ozone (warm season) were estimated using European-wide hybrid land-use regression models (100 m × 100 m) and assigned to baseline residential addresses. We used Cox proportional hazard models to evaluate the association between air pollution and mortality, accounting for demographic and socioeconomic factors. We additionally applied indirect adjustment for smoking and body mass index (BMI). Results: During 47,023,454 person-years of follow-up, 803,881 people died from natural causes. Long-term exposure to PM2.5 (mean: 12.4 µg/m3), NO2 (20.3 µg/m3), and/or BC (1.0 × 10-5/m) was statistically significantly associated with all studied mortality outcomes except CKD. A 5 µg/m3 increase in PM2.5 was associated with higher mortality from all-natural causes (hazard ratio 1.11; 95% confidence interval 1.09–1.13), cardiovascular disease (1.09; 1.07–1.12), respiratory disease (1.11; 1.07–1.15), lung cancer (1.19; 1.15–1.24), diabetes (1.10; 1.04–1.16), dementia (1.05; 1.00–1.10), psychiatric disorders (1.38; 1.27–1.50), asthma (1.13; 0.94–1.36), and ALRI (1.14; 1.09–1.20). Associations with long-term exposure to ozone (mean: 80.2 µg/m3) were generally negative but became significantly positive for several endpoints in two-pollutant models. Generally, associations were attenuated but remained significant after indirect adjustment for smoking and BMI. Conclusion: Long-term exposure to PM2.5, NO2, and/or BC in Denmark were associated with mortality beyond cardiorespiratory diseases, including diabetes, dementia, psychiatric disorders, asthma, and ALRI. © 2022 The Authors
Published: 2022

5. Variability in the association between long-term exposure to ambient air pollution and mortality by exposure assessment method and covariate adjustment: A census-based country-wide cohort study

Author: Bauwelinck, M. Chen, J. de Hoogh, K. Katsouyanni, K. Rodopoulou, S. Samoli, E. Andersen, Z.J. Atkinson, R. Casas, L. Deboosere, P. Demoury, C. Janssen, N. Klompmaker, J.O. Lefebvre, W. Mehta, A.J. Nawrot, T.S. Oftedal, B. Renzi, M. Stafoggia, M. Strak, M. Vandenheede, H. Vanpoucke, C. Van Nieuwenhuyse, A. Vienneau, D. Brunekreef, B. Hoek, G.
Abstract: Background: Ambient air pollution exposure has been associated with higher mortality risk in numerous studies. We assessed potential variability in the magnitude of this association for non-accidental, cardiovascular disease, respiratory disease, and lung cancer mortality in a country-wide administrative cohort by exposure assessment method and by adjustment for geographic subdivisions. Methods: We used the Belgian 2001 census linked to population and mortality register including nearly 5.5 million adults aged ≥30 (mean follow-up: 9.97 years). Annual mean concentrations for fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC) and ozone (O3) were assessed at baseline residential address using two exposure methods; Europe-wide hybrid land use regression (LUR) models [100x100m], and Belgium-wide interpolation-dispersion (RIO-IFDM) models [25x25m]. We used Cox proportional hazards models with age as the underlying time scale and adjusted for various individual and area-level covariates. We further adjusted main models for two different area-levels following the European Nomenclature of Territorial Units for Statistics (NUTS); NUTS-1 (n = 3), or NUTS-3 (n = 43). Results: We found no consistent differences between both exposure methods. We observed most robust associations with lung cancer mortality. Hazard Ratios (HRs) per 10 μg/m3 increase for NO2 were 1.060 (95%CI 1.042-1.078) [hybrid LUR] and 1.040 (95%CI 1.022-1.058) [RIO-IFDM]. Associations with non-accidental, respiratory disease and cardiovascular disease mortality were generally null in main models but were enhanced after further adjustment for NUTS-1 or NUTS-3. HRs for non-accidental mortality per 5 μg/m3 increase for PM2.5 for the main model using hybrid LUR exposure were 1.023 (95%CI 1.011-1.035). After including random effects HRs were 1.044 (95%CI 1.033-1.057) [NUTS-1] and 1.076 (95%CI 1.060-1.092) [NUTS-3]. Conclusion: Long-term air pollution exposure was associated with higher lung cancer mortality risk but not consistently with the other studied causes. Magnitude of associations varied by adjustment for geographic subdivisions, area-level socio-economic covariates and less by exposure assessment method. © 2021
Published: 2022

6. Long-term exposure to fine particle elemental components and mortality in Europe: Results from six European administrative cohorts within the ELAPSE project

Author: Rodopoulou, S. Stafoggia, M. Chen, J. de Hoogh, K. Bauwelinck, M. Mehta, A.J. Klompmaker, J.O. Oftedal, B. Vienneau, D. Janssen, N.A.H. Strak, M. Andersen, Z.J. Renzi, M. Cesaroni, G. Nordheim, C.F. Bekkevold, T. Atkinson, R. Forastiere, F. Katsouyanni, K. Brunekreef, B. Samoli, E. Hoek, G.
Abstract: Evidence for the association between long-term exposure to ambient particulate matter components and mortality from natural causes is sparse and inconsistent. We evaluated this association in six large administrative cohorts in the framework of the Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE) project. We analyzed data from country-wide administrative cohorts in Norway, Denmark, the Netherlands, Belgium, Switzerland and in Rome (Italy). Annual 2010 mean concentrations of copper (Cu), iron (Fe), potassium (K), nickel (Ni), sulfur (S), silicon (Si), vanadium (V) and zinc (Zn) in fine particulate matter (PM2.5) were estimated using 100 × 100 m Europe-wide hybrid land use regression models assigned to the participants' residential addresses. We applied cohort-specific Cox proportional hazard models controlling for area- and individual-level covariates to evaluate associations with natural mortality. Two pollutant models adjusting for PM2.5 total mass or nitrogen dioxide (NO2) were also applied. We pooled cohort-specific estimates using a random effects meta-analysis. We included almost 27 million participants contributing more than 240 million person-years. All components except Zn were significantly associated with natural mortality [pooled Hazard Ratios (HRs) (95% CI): 1.037 (1.014, 1.060) per 5 ng/m3 Cu; 1.069 (1.031, 1.108) per 100 ng/m3 Fe; 1.039 (1.018, 1.062) per 50 ng/m3 K; 1.024 (1.006, 1.043) per 1 ng/m3 Ni; 1.036 (1.016, 1.057) per 200 ng/m3 S; 1.152 (1.048, 1.266) per 100 ng/m3 Si; 1.020 (1.006, 1.034) per 2 ng/m3 V]. Only K and Si were robust to PM2.5 or NO2 adjustment [pooled HRs (95% CI) per 50 ng/m3 in K: 1.025 (1.008, 1.044), 1.020 (0.999, 1.042) and per 100 ng/m3 in Si: 1.121 (1.039, 1.209), 1.068 (1.022, 1.117) adjusted for PM2.5 and NO2 correspondingly]. Our findings indicate an association of natural mortality with most components, which was reduced after adjustment for PM2.5 and especially NO2. © 2021
Published: 2022

7. Experimental Investigation and RSM Modeling of the Effects of Injection Timing on the Performance and NOx Emissions of a Micro-Cogeneration Unit Fueled with Biodiesel Blends

Author: Caligiuri, C, Bietresato, M, Algieri, A, Baratieri, M, and Renzi, M
Subjects: injection timing, biodiesel, NOx emissions reduction, micro-cogeneration, response-surface methodology
Published: 2022

8. Sustainable business practices for transformative change: The case of Eataly

Author: Pietro L. D., Renzi M. F., Edvardsson B., Samuel Petros Sebhatu, Bo Enquist, Bo Edvardsson, Pietro, L. D., Renzi, M. F., and Edvardsson, B.
Abstract: Contributing to sustainable development in line with the UN Agenda 2030 (UN, 2015) has become a key goal of many governments, businesses, organizations, and individuals. The present chapter aims to analyze the role that sustainable practices can play in enabling and supporting such a transformation. Our focus is on the dynamics and mechanisms that trigger transformative change through the adoption of sustainable practices. The case of Eataly (an Italian food chain) is presented in the form of a narrative based on in-depth interviews, company documents, and observation data. An analysis of the narrative shows the power of values resonance, in which Eataly’s core values are in line with foundational values in society and the values of a majority of customers. This case study shows that business values, and the sustainable practices that emerge from them, contribute to value creation throughout the relationships that the company establishes and manages with all its stakeholders, which together form a dynamic and values-driven business that can be described as a sustainable service ecosystem. Accordingly, sustainable and innovative practices feed each one another, triggering a continuous cycle of transformative change that starts with values resonance with the stakeholders.
Published: 2021

9. Covid-19 Pandemic, Sustainability and Social Responsibility: Perspectives During the Lockdown

Author: Ungaro V., Di Pietro L., Renzi M. F., Guglielmetti R., Pasca M. G., Christos Sarmaniotis, Ungaro, V., Di Pietro, L., Renzi, M. F., Guglielmetti, R., and Pasca, M. G.
Published: 2021

10. Covid-19 Pandemic and Sustainable Consumers Behaviours: Consumer's Perspectives During the Lockdown

Author: Ungaro V., Di Pietro., Renzi M. F., Arcese G., Pasca M. G, Catrin Johansson and Volker Mauerhofer, Ungaro, V., Pietro., Di, Renzi, M. F., Arcese, G., and Pasca M., G
Published: 2021

11. Sustainable business practice for Transformative Change: The Case of Eataly

Author: Di Pietro Laura, Renzi M. F., Edvardsson B., Sebhatu, S.P., Enquist, B., Edvardsson, B., DI PIETRO, Laura, Renzi, M. F., and Edvardsson, B.
Published: 2021

12. Transformative Service Research: a systematic literature review

Author: Ungaro V., Di Pietro L., Renzi M. F., Guglielmetti R., Pasca M. G., Evert Gummesson, Cristina Mele, Francesco Polese, Ungaro, V., Di Pietro, L., Renzi, M. F., Guglielmetti, R., and Pasca, M. G.
Published: 2021

13. Education and Volunteering to foster the societal sustainable transformation

Author: Di Pietro Laura, Renzi M. F., Guglielmetti R., Ungaro V., Pasca M. G., Catrin Johansson and Volker Mauerhofer, DI PIETRO, Laura, Renzi, M. F., Guglielmetti, R., Ungaro, V., and Pasca, M. G.
Published: 2021

14. La gamification nell’industria del turismo: una revisione sistematica della letteratura

Author: Pasca M. G., Renzi M. F., Guglielmetti Mugion R., Toni M., Di Pietro L., Benedetta Esposito, Ornella Malandrino, Maria Rosaria Sessa, Daniela Sica, Pasca, M. G., Renzi, M. F., Guglielmetti Mugion, R., Toni, M., and Di Pietro, L.
Published: 2020

15. Pressures and impacts on structure, functioning and services in marine, terrestrial, and transitional ecosystems

Author: Manes, F., Vizzini, S., Buonocore, E., Renzi, M., Franzese, P. P., Manes, F., Vizzini, S., Buonocore, E., Renzi, M., and Franzese Pier, Paolo
Subjects: Editorial
Abstract: "-"
Published: 2020

16. Transformative Service Research and (service) well-being: a consumer’s perspective

Author: Ungaro V., Di Pietro L., Guglielmetti Mugion R., Pasca M. G., Renzi M. F., Christos Sarmaniotis, Ungaro, V., Di Pietro, L., Guglielmetti Mugion, R., Pasca, M. G., and Renzi, M. F.
Published: 2020

17. Torque Prediction Model of a CI Engine for Agricultural Purposes Based on Exhaust Gas Temperatures and CFD-FVM Methodologies Validated with Experimental Tests

Author: Bietresato, M, Selmo, F, Renzi, M, and Mazzetto, F
Subjects: Technology, QH301-705.5, Physics, QC1-999, indirect estimation, RSM, torque, exhaust gas temperature, compression-ignition engine, thermocouples, CFD, FVM, agricultural machines, Engineering (General). Civil engineering (General), Chemistry, TA1-2040, Biology (General), QD1-999
Abstract: A truly universal system to optimize consumptions, monitor operation and predict maintenance interventions for internal combustion engines must be independent of onboard systems, if present. One of the least invasive methods of detecting engine performance involves the measurement of the exhaust gas temperature (EGT), which can be related to the instant torque through thermodynamic relations. The practical implementation of such a system requires great care since its torque-predictive capabilities are strongly influenced by the position chosen for the temperature-detection point(s) along the exhaust line, specific for each engine, the type of installation for the thermocouples, and the thermal characteristics of the interposed materials. After performing some preliminary tests at the dynamometric brake on a compression-ignition engine for agricultural purposes equipped with three thermocouples at different points in the exhaust duct, a novel procedure was developed to: (1) tune a CFD-FVM-model of the exhaust pipe and determine many unknown thermodynamic parameters concerning the engine (including the real EGT at the exhaust valve outlet in some engine operative conditions), (2) use the CFD-FVM results to considerably increase the predictive capability of an indirect torque-detection strategy based on the EGT. The joint use of the CFD-FVM software, Response Surface Method, and specific optimization algorithms was fundamental to these aims and granted the experimenters a full mastery of systems’ non-linearity and a maximum relative error on the torque estimations of 2.9%.
Published: 2021

18. Modeling multi-level survival data in multi-center epidemiological cohort studies: Applications from the ELAPSE project

Author: Samoli, E. Rodopoulou, S. Hvidtfeldt, U.A. Wolf, K. Stafoggia, M. Brunekreef, B. Strak, M. Chen, J. Andersen, Z.J. Atkinson, R. Bauwelinck, M. Bellander, T. Brandt, J. Cesaroni, G. Forastiere, F. Fecht, D. Gulliver, J. Hertel, O. Hoffmann, B. de Hoogh, K. Janssen, N.A.H. Ketzel, M. Klompmaker, J.O. Liu, S. Ljungman, P. Nagel, G. Oftedal, B. Pershagen, G. Peters, A. Raaschou-Nielsen, O. Renzi, M. Kristoffersen, D.T. Severi, G. Sigsgaard, T. Vienneau, D. Weinmayr, G. Hoek, G. Katsouyanni, K.
Abstract: Background: We evaluated methods for the analysis of multi-level survival data using a pooled dataset of 14 cohorts participating in the ELAPSE project investigating associations between residential exposure to low levels of air pollution (PM2.5 and NO2) and health (natural-cause mortality and cerebrovascular, coronary and lung cancer incidence). Methods: We applied five approaches in a multivariable Cox model to account for the first level of clustering corresponding to cohort specification: (1) not accounting for the cohort or using (2) indicator variables, (3) strata, (4) a frailty term in frailty Cox models, (5) a random intercept under a mixed Cox, for cohort identification. We accounted for the second level of clustering due to common characteristics in the residential area by (1) a random intercept per small area or (2) applying variance correction. We assessed the stratified, frailty and mixed Cox approach through simulations under different scenarios for heterogeneity in the underlying hazards and the air pollution effects. Results: Effect estimates were stable under approaches used to adjust for cohort but substantially differed when no adjustment was applied. Further adjustment for the small area grouping increased the effect estimates’ standard errors. Simulations confirmed identical results between the stratified and frailty models. In ELAPSE we selected a stratified multivariable Cox model to account for between-cohort heterogeneity without adjustment for small area level, due to the small number of subjects and events in the latter. Conclusions: Our study supports the need to account for between-cohort heterogeneity in multi-center collaborations using pooled individual level data. © 2021 The Authors
Published: 2021

19. Long-term exposure to fine particle elemental components and natural and cause-specific mortality—a pooled analysis of eight european cohorts within the ELAPSE project

Author: Chen, J. Rodopoulou, S. de Hoogh, K. Strak, M. Andersen, Z.J. Atkinson, R. Bauwelinck, M. Bellander, T. Brandt, J. Cesaroni, G. Concin, H. Fecht, D. Forastiere, F. Gulliver, J. Hertel, O. Hoffmann, B. Hvidtfeldt, U.A. Janssen, N.A.H. Jöckel, K.-H. Jørgensen, J. Katsouyanni, K. Ketzel, M. Klompmaker, J.O. Lager, A. Leander, K. Liu, S. Ljungman, P. Macdonald, C.J. Magnusson, P.K.E. Mehta, A. Nagel, G. Oftedal, B. Pershagen, G. Peters, A. Raaschou-Nielsen, O. Renzi, M. Rizzuto, D. Samoli, E. van der Schouw, Y.T. Schramm, S. Schwarze, P. Sigsgaard, T. Sørensen, M. Stafoggia, M. Tjønneland, A. Vienneau, D. Weinmayr, G. Wolf, K. Brunekreef, B. Hoek, G.
Abstract: BACKGROUND: Inconsistent associations between long-term exposure to particles with an aerodynamic diameter ≤2:5 lm [fine particulate matter (PM2:5)] components and mortality have been reported, partly related to challenges in exposure assessment. OBJECTIVES: We investigated the associations between long-term exposure to PM2:5 elemental components and mortality in a large pooled European cohort; to compare health effects of PM2:5 components estimated with two exposure modeling approaches, namely, supervised linear regression (SLR) and random forest (RF) algorithms. METHODS: We pooled data from eight European cohorts with 323,782 participants, average age 49 y at baseline (1985–2005). Residential exposure to 2010 annual average concentration of eight PM2:5 components [copper (Cu), iron (Fe), potassium (K), nickel (Ni), sulfur (S), silicon (Si), vanadium (V), and zinc (Zn)] was estimated with Europe-wide SLR and RF models at a 100 × 100 m scale. We applied Cox proportional hazards models to investigate the associations between components and natural and cause-specific mortality. In addition, two-pollutant analyses were conducted by adjusting each component for PM2:5 mass and nitrogen dioxide (NO2) separately. RESULTS: We observed 46,640 natural-cause deaths with 6,317,235 person-years and an average follow-up of 19.5 y. All SLR-modeled components were statistically significantly associated with natural-cause mortality in single-pollutant models with hazard ratios (HRs) from 1.05 to 1.27. Similar HRs were observed for RF-modeled Cu, Fe, K, S, V, and Zn with wider confidence intervals (CIs). HRs for SLR-modeled Ni, S, Si, V, and Zn remained above unity and (almost) significant after adjustment for both PM2:5 and NO2. HRs only remained (almost) significant for RF-modeled K and V in two-pollutant models. The HRs for V were 1.03 (95% CI: 1.02, 1.05) and 1.06 (95% CI: 1.02, 1.10) for SLR-and RF-modeled exposures, respectively, per 2 ng=m3, adjusting for PM2:5 mass. Associations with cause-specific mortality were less consistent in two-pollutant models. CONCLUSION: Long-term exposure to V in PM2:5 was most consistently associated with increased mortality. Associations for the other components were weaker for exposure modeled with RF than SLR in two-pollutant models. https://doi.org/10.1289/EHP8368. © 2021, Public Health Services, US Dept of Health and Human Services. All rights reserved.
Published: 2021

20. Long-term exposure to low-level ambient air pollution and incidence of stroke and coronary heart disease: a pooled analysis of six European cohorts within the ELAPSE project

Author: Wolf, K. Hoffmann, B. Andersen, Z.J. Atkinson, R.W. Bauwelinck, M. Bellander, T. Brandt, J. Brunekreef, B. Cesaroni, G. Chen, J. de Faire, U. de Hoogh, K. Fecht, D. Forastiere, F. Gulliver, J. Hertel, O. Hvidtfeldt, U.A. Janssen, N.A.H. Jørgensen, J.T. Katsouyanni, K. Ketzel, M. Klompmaker, J.O. Lager, A. Liu, S. MacDonald, C.J. Magnusson, P.K.E. Mehta, A.J. Nagel, G. Oftedal, B. Pedersen, N.L. Pershagen, G. Raaschou-Nielsen, O. Renzi, M. Rizzuto, D. Rodopoulou, S. Samoli, E. van der Schouw, Y.T. Schramm, S. Schwarze, P. Sigsgaard, T. Sørensen, M. Stafoggia, M. Strak, M. Tjønneland, A. Verschuren, W.M.M. Vienneau, D. Weinmayr, G. Hoek, G. Peters, A. Ljungman, P.L.S.
Abstract: BACKGROUND: Long-term exposure to outdoor air pollution increases the risk of cardiovascular disease, but evidence is unclear on the health effects of exposure to pollutant concentrations lower than current EU and US standards and WHO guideline limits. Within the multicentre study Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE), we investigated the associations of long-term exposures to fine particulate matter (PM2·5), nitrogen dioxide (NO2), black carbon, and warm-season ozone (O3) with the incidence of stroke and acute coronary heart disease. METHODS: We did a pooled analysis of individual data from six population-based cohort studies within ELAPSE, from Sweden, Denmark, the Netherlands, and Germany (recruited 1992-2004), and harmonised individual and area-level variables between cohorts. Participants (all adults) were followed up until migration from the study area, death, or incident stroke or coronary heart disease, or end of follow-up (2011-15). Mean 2010 air pollution concentrations from centrally developed European-wide land use regression models were assigned to participants' baseline residential addresses. We used Cox proportional hazards models with increasing levels of covariate adjustment to investigate the association of air pollution exposure with incidence of stroke and coronary heart disease. We assessed the shape of the concentration-response function and did subset analyses of participants living at pollutant concentrations lower than predefined values. FINDINGS: From the pooled ELAPSE cohorts, data on 137 148 participants were analysed in our fully adjusted model. During a median follow-up of 17·2 years (IQR 13·8-19·5), we observed 6950 incident events of stroke and 10 071 incident events of coronary heart disease. Incidence of stroke was associated with PM2·5 (hazard ratio 1·10 [95% CI 1·01-1·21] per 5 μg/m3 increase), NO2 (1·08 [1·04-1·12] per 10 μg/m3 increase), and black carbon (1·06 [1·02-1·10] per 0·5 10-5/m increase), whereas coronary heart disease incidence was only associated with NO2 (1·04 [1·01-1·07]). Warm-season O3 was not associated with an increase in either outcome. Concentration-response curves indicated no evidence of a threshold below which air pollutant concentrations are not harmful for cardiovascular health. Effect estimates for PM2·5 and NO2 remained elevated even when restricting analyses to participants exposed to pollutant concentrations lower than the EU limit values of 25 μg/m3 for PM2·5 and 40 μg/m3 for NO2. INTERPRETATION: Long-term air pollution exposure was associated with incidence of stroke and coronary heart disease, even at pollutant concentrations lower than current limit values. FUNDING: Health Effects Institute. Copyright © 2021 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.
Published: 2021

21. Long-term exposure to fine particle elemental components and lung cancer incidence in the ELAPSE pooled cohort

Author: Hvidtfeldt, U.A. Chen, J. Andersen, Z.J. Atkinson, R. Bauwelinck, M. Bellander, T. Brandt, J. Brunekreef, B. Cesaroni, G. Concin, H. Fecht, D. Forastiere, F. van Gils, C.H. Gulliver, J. Hertel, O. Hoek, G. Hoffmann, B. de Hoogh, K. Janssen, N. Jørgensen, J.T. Katsouyanni, K. Jöckel, K.-H. Ketzel, M. Klompmaker, J.O. Lang, A. Leander, K. Liu, S. Ljungman, P.L.S. Magnusson, P.K.E. Mehta, A.J. Nagel, G. Oftedal, B. Pershagen, G. Peter, R.S. Peters, A. Renzi, M. Rizzuto, D. Rodopoulou, S. Samoli, E. Schwarze, P.E. Severi, G. Sigsgaard, T. Stafoggia, M. Strak, M. Vienneau, D. Weinmayr, G. Wolf, K. Raaschou-Nielsen, O.
Subjects: complex mixtures
Abstract: Background: An association between long-term exposure to fine particulate matter (PM2.5) and lung cancer has been established in previous studies. PM2.5 is a complex mixture of chemical components from various sources and little is known about whether certain components contribute specifically to the associated lung cancer risk. The present study builds on recent findings from the “Effects of Low-level Air Pollution: A Study in Europe” (ELAPSE) collaboration and addresses the potential association between specific elemental components of PM2.5 and lung cancer incidence. Methods: We pooled seven cohorts from across Europe and assigned exposure estimates for eight components of PM2.5 representing non-tail pipe emissions (copper (Cu), iron (Fe), and zinc (Zn)), long-range transport (sulfur (S)), oil burning/industry emissions (nickel (Ni), vanadium (V)), crustal material (silicon (Si)), and biomass burning (potassium (K)) to cohort participants’ baseline residential address based on 100 m by 100 m grids from newly developed hybrid models combining air pollution monitoring, land use data, satellite observations, and dispersion model estimates. We applied stratified Cox proportional hazards models, adjusting for potential confounders (age, sex, calendar year, marital status, smoking, body mass index, employment status, and neighborhood-level socio-economic status). Results: The pooled study population comprised 306,550 individuals with 3916 incident lung cancer events during 5,541,672 person-years of follow-up. We observed a positive association between exposure to all eight components and lung cancer incidence, with adjusted HRs of 1.10 (95% CI 1.05, 1.16) per 50 ng/m3 PM2.5 K, 1.09 (95% CI 1.02, 1.15) per 1 ng/m3 PM2.5 Ni, 1.22 (95% CI 1.11, 1.35) per 200 ng/m3 PM2.5 S, and 1.07 (95% CI 1.02, 1.12) per 200 ng/m3 PM2.5 V. Effect estimates were largely unaffected by adjustment for nitrogen dioxide (NO2). After adjustment for PM2.5 mass, effect estimates of K, Ni, S, and V were slightly attenuated, whereas effect estimates of Cu, Si, Fe, and Zn became null or negative. Conclusions: Our results point towards an increased risk of lung cancer in connection with sources of combustion particles from oil and biomass burning and secondary inorganic aerosols rather than non-exhaust traffic emissions. Specific limit values or guidelines targeting these specific PM2.5 components may prove helpful in future lung cancer prevention strategies. © 2020 Elsevier Inc.
Published: 2021

22. Bioblitz 2018 Parco Regionale della Maremma

Author: Sforzi, A., Bastianini, M., Canovai, R., Cantini, D., Castagnini, P., Chelazzi, L., Dragonetti, M., Fackovcova, Z., Fanciulli, P. P., Fastelli, P., Ferretti, F., Forbicioni, F., Gabellini, A., Lenzini, L., Letardi, A., Montioni, F., Nappini, S., Paoli, L., Perini, C., Pezzi, G., Pezzo, F., Renzi, M., Rizzo Pinna, V., Spilinga, C., Vannini, A., Vitillo, C., Sforzi, A., Bastianini, M., Canovai, R., Cantini, D., Castagnini, P., Chelazzi, L., Dragonetti, M., Fackovcova, Z., Fanciulli, P. P., Fastelli, P., Ferretti, F., Forbicioni, F., Gabellini, A., Lenzini, L., Letardi, A., Montioni, F., Nappini, S., Paoli, L., Perini, C., Pezzi, G., Pezzo, F., Renzi, M., Rizzo Pinna, V., Spilinga, C., Vannini, A., and Vitillo, C.
Subjects: Citizen Science, Italy, Bioblitz, Citizen Science, Bioblitz, Italy
Abstract: In recent decades, many natural history museums in Europe have integrated their traditional functions with new ways of interacting with visitors and local communities. In particular, the need to adapt their mission according to the changes in modern society has led them to develop initiatives aiming at an active involvement of the public in scientific research. This is one of the inspiring principles of Citizen Science. BioBlitz are among the most popular activities dedicated to biodiversity in this field. In line with the inspiring principles of this cultural revolution, since 2012 the Maremma Natural History Museum organized public participation initiatives for the collection of biodiversity data. We hereby report the main results of the BioBlitz 2018 organized by the Maremma Natural History Museum in the Talamone area, located in the southern portion of the Uccellina Hills. Four hundred and ninety eight taxa were sampled and identified, 447 of which at the level of species and 10 at the level of subspecies; the remaining refer to higher taxonomic levels. 31 protected species and 10 endangered species were found in the area; moreover, 6 alien species and one endemic species were detected. The main feature that distinguished BioBlitz 2018 to others conducted in previous years was the large number of participants. The data collected increased the scientific knowledge of the southern portion of the Maremma Regional Park, less known than other areas of the same protected area.
Published: 2019

23. Road traffic noise, mortality and incidence of cardio-cerebrovascular diseases in Rome

Author: Renzi M, Lisa Bauleo, Massimo Stafoggia, Paola Michelozzi, Francesco Forastiere, and Carla Ancona
Subjects: Burden of disease, Noise, business.industry, Environmental health, Incidence (epidemiology), General Earth and Planetary Sciences, Medicine, business, Road traffic, General Environmental Science
Abstract: Background/Aim: Transportation noise is among the most important environmental exposures contributing to the burden of disease in Europe. The aim of the study is to assess whether long-term exposur...
Published: 2020
Full Text: View/download PDF

24. Meta-analysis on short-term exposure to ambient ultrafine particles and respiratory morbidity

Author: Samoli, E. Rodopoulou, S. Schneider, A. Morawska, L. Stafoggia, M. Renzi, M. Breitner, S. Lanki, T. Pickford, R. Schikowski, T. Enembe, O. Zhang, S. Zhao, Q. Peters, A.
Abstract: Aim: There is growing interest in the health effects following exposure to ambient particles with a diameter
Published: 2020

25. Understanding the impact of peer-to-peer platforms on micro-entrepreneurship engagement in sharing economy. Evidence from Italy, Greece and China

Author: Renzi, M. F., Pantouvakis, A., Sigala, M., Toni, M., and Zanda, S.
Published: 2019

26. Short-term association between daily PM2.5 and PM10 concentrations and cardiovascular admissions in Italy - a national approach

Author: Stafoggia M, Renzi M, Gariazzo C, Fasola S, Michelozzi P, Forastiere F, Davoli M, Viegi G, and BEEP Collaborative Group
Subjects: hospital admissions, PM2.5, PM2.10
Abstract: n.a.
Published: 2019

27. Association between particulate matter and cause-specific mortality in five Italian regions: results of the BEEP project

Author: Renzi M, Gariazzo C, Michelozzi P, Galassi C, Cernigliaro A, Bisceglia L, Ottone M, Forastiere F, Viegi G, Stafoggia M, and BEEP Collaborative Group
Subjects: PM10, PM2.5, mortality
Abstract: n.a.
Published: 2019

28. Gamification in Airbnb: benefits and risks

Author: Sigala, M., Toni, M., Renzi, M. F., Pietro, L. D., Roberta Guglielmetti Mugion, Sigala, Marianna, Toni, Martina, Renzi, Maria Francesca, DI PIETRO, Laura, and GUGLIELMETTI MUGION, Roberta
Subjects: mechanic, Funware, P2P platform, tourism, impacts SIDS, Gamification
Abstract: Gamification has been studied in various contexts, but not in P2P platforms. Research has also overemphasised the benefits of gamification ignoring its boundaries and counterproductive impacts. This study addresses these gaps by using Airbnb as a case study for investigating the application and (negative and positive) impacts of gamification on hosts’ motivation and behaviour. Secondary data were used for examining the funware design of Airbnb, while gamification theory is reviewed for designing a qualitative study with Airbnb hosts for investigating their perceptions and reactions to the Airbnb funware design.
Published: 2019

29. A nationwide study of particulate matter and daily hospitalizations for respiratory diseases in Italy

Author: Renzi M, Michelozzi P, Gariazzo C, Maio S, Davoli M, Forastiere F, Giovanni Viegi, Stafoggia M, and BEEP Collaborative Group
Subjects: PM10, respiratory diseases, PM2.5
Abstract: n.a.
Published: 2019

30. The Changing Landscape for Stroke Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Author: Huisman, M. V., Rothman, K. J., Paquette, M., Teutsch, C., Diener, H. -C., Dubner, S. J., Halperin, J. L., C. S., Ma, Zint, K., Elsaesser, A., Bartels, D. B., Lip, G. Y. H., Abban, D., Abdul, N., Abelson, M., Ackermann, A., Adams, F., Adams, L., Adragao, P., Ageno, W., Aggarwal, R., Agosti, S., Marin, J. A., Aguilar, F., Aguilar Linares, J. A., Aguinaga, L., Ahmad, Z., Ainsworth, P., Al Ghalayini, K., Al Ismail, S., Alasfar, A., Alawwa, A., Al-Dallow, R., Alderson, L., Alexopoulos, D., Ali, A., Ali, M., Aliyar, P., Al-Joundi, T., Al Mahameed, S., Almassi, H., Almuti, K., Al-Obaidi, M., Alshehri, M., Altmann, U., Alves, A. R., Al-Zoebi, A., Amara, W., Amelot, M., Amjadi, N., Ammirati, F., Andrawis, N., Angoulvant, D., Annoni, G., Ansalone, G., Antonescu, S. A., Ariani, M., Arias, J. C., Armero, S., Arora, R., Arora, C., Ashcraft, W., Aslam, M. S., Astesiano, A., Audouin, P., Augenbraun, C., Aydin, S., Azar, R., Azim, A., Aziz, S., Backes, L. M., Baig, M., Bains, S., Bakbak, A., Baker, S., Bakhtiar, K., Bala, R., Banayan, J., Bandh, S., Bando, S., Banerjee, S., Bank, A., Barbarash, O., Baron, G., Barr, C., Barrera, C., Barton, J., Kes, V. B., Baula, G., Bayeh, H., Bazargani, N., Behrens, S., Bell, A., Benezet-Mazuecos, J., Benhalima, B., Berdague, P., Berg van den, B. J., Bergen van, P. F. M. M., Berngard, E., Bernstein, R., Berrospi, P., Berti, S., Bertomeu, V., Berz, A., Bettencourt, P., Betzu, R., Beyer-Westendorf, J., Bhagwat, R., Black, T., Blanco Ibaceta, J. H., Bloom, S., Blumberg, E., Bo, M., Bockisch, V., Bohmer, E., Bongiorni, M. G., Boriani, G., Bosch, R., Boswijk, D. J., Bott, J., Bottacchi, E., Kalan, M. B., Brandes, A., Bratland, B., Brautigam, D., Breton, N., Brouwers, P. J. A. M., Browne, K., Bruguera, J., Brunehaut, M., Brunschwig, C., Buathier, H., Buhl, A., Bullinga, J., Butcher, K., Cabrera Honorio, J. W., Caccavo, A., Cadinot, D., Cai, S., Calvi, V., Camm, J., Candeias, R., Capo, J., Capucci, A., Cardoso, J. N., Duarte Vera, Y. C., Carlson, B., Carvalho, P., Cary, S., Casanova, R., Casu, G., Cattan, S., Cavallini, C., Cayla, G., Cha, T. J., Cha, K. S., Chaaban, S., Chae, J. K., Challappa, K., Chand, S., Chandrashekar, H., Chang, M., Charbel, P., Chartier, L., Chatterjee, K., Cheema, A., Chen, S. -A., Chevallereau, P., Chiang, F. -T., Chiarella, F., Chih-Chan, L., Cho, Y. K., Choi, D. J., Chouinard, G., Danny, Chow, H. F., Chrysos, D., Chumakova, G., Jose Roberto Chuquiure Valenzuela, E. J., Cieza-Lara, T., Nica, V. C., Ciobotaru, V., Cislowski, D., Citerne, O., Claus, M., Clay, A., Clifford, P., Cohen, S., Cohen, A., Colivicchi, F., Collins, R., Compton, S., Connors, S., Conti, A., Buenostro, G. C., Coodley, G., Cooper, M., Corbett, L., Corey, O., Coronel, J., Corrigan, J., Cotrina Pereyra, R. Y., Cottin, Y., Coutu, B., Cracan, A., Crean, P., Crenshaw, J., Crijns, H. J. G. M., Crump, C., Cucher, F., Cudmore, D., Cui, L., Culp, J., Darius, H., Dary, P., Dascotte, O., Dauber, I., Davee, T., Davies, R., Davis, G., Davy, J. -M., Dayer, M., De La Briolle, A., de Mora, M., De Teresa, E., De Wolf, L., Decoulx, E., Deepak, S., Defaye, P., Del-Carpio Munoz, F., Brkljacic, D. D., Deluche, L., Destrac, S., Deumite, N. J., Di Legge, S., Dibon, O., Diemberger, I., Dillinger, J., Dionisio, P., Naydenov, S., Dotani, I., Dotcheva, E., D'Souza, A., Dubrey, S., Ducrocq, X., Dupljakov, D., Duthinh, V., Dutra, O. P., Dutta, D., Duvilla, N., Dy, J., Dziewas, R., Eaton, C., Eaves, W., Ebinger, M., Eck van, J. W. M., Edwards, T., Egocheaga, I., Ehrlich, C., Eisenberg, S., El Hallak, A., El Jabali, A., El Mahmoud, R., El Shahawy, M., Eldadah, Z., Elghelbazouri, F., Elhag, O., El-Hamdani, M., Elias, D., Ellery, A., El-Sayed, H., Elvan, A., Erickson, B., Espaliat, E., Essandoh, L., Everington, T., Evonich, R., Ezhov, A., Facila, L., Farsad, R., Fayard, M., Fedele, F., Gomes Ferreira, L. G., Ferreira, D., Santos, J. F., Ferrier, A., Finsen, A., First, B., Fisher, R., Floyd, J., Folk, T., Fonseca, C., Fonseca, L., Forman, S., Forsgren, M., Foster, M., Foster, N., Frais, M., Frandsen, B., Frappe, T., Freixa, R., French, W., Freydlin, M., Frickel, S., Fruntelata, A. G., Fujii, S., Fujino, Y., Fukunaga, H., Furukawa, Y., Gabelmann, M., Gabris, M., Gadsboll, N., Galin, P., Galinier, M., Ganim, R., Garcia, R., Quintana, A. G., Gartenlaub, O., Genz, C., Georger, F., Georges, J. -L., Georgeson, S., Ghanbasha, A., Giedrimas, E., Gierba, M., Gillespie, E., Giniger, A., Gkotsis, A., Gmehling, J., Gniot, J., Goethals, P., Goldberg, R., Goldmann, B., Goldscher, D., Golitsyn, S., Gomez Lopez, E. A., Gomez Mesa, J. E., Gonzalez, E., Cocina, E. G., Juanatey, C. G., Gorbunov, V., Gordon, B., Gorka, H., Gornick, C., Gorog, D., Goss, F., Gotte, A., Goube, P., Goudevenos, I., Goulden, D., Graham, B., Grande, A., Greco, C., Green, M., Greer, G., Gremmler, U., Grena, P., Grinshstein, Y., Grond, M., Gronda, E., Grondin, F., Gronefeld, G., Groot de, J. R., Guardigli, G., Guarnieri, T., Caiedo, C. G., Guignier, A., Gulizia, M., Gumbley, M., Gupta, D., Hack, T., Haerer, W., Hakas, J., Hall, C., Hampsey, J., Hananis, G., Hanbali, B., Handel, F., Hargrove, J., Hargroves, D., Harris, K., Hartley, D., Haruna, T., Hata, Y., Hayek, E., Healey, J., Hearne, S., Heggelund, G., Hemels, M. E. W., Hemery, Y., Henein, S., Henz, B., Her, S. -H., Hermany, P., Hernandes, M. E., Higashino, Y., Hill, M., Hisadome, T., Hishida, E., Hitchcock, J., Hoffer, E., Hoghton, M., Holmes, C., Hong, S. K., Houppe Nousse, M. -P., Howard, V., Hsu, L. F., Huang, C. -H., Huckins, D., Huehnergarth, K., Huizenga, A., Huntley, R., Hussein, G., Hwang, G. -S., Igbokidi, O., Iglesias, I., Ikpoh, M., Imberti, D., Ince, H., Indolfi, C., Ionova, T., Ip, J., Irles, D., Iseki, H., Ismail, Y., Israel, N., Isserman, S., Iteld, B., Ivanchura, G., Iyer, R., Iyer, V., Iza Villanueva, R. O., Jackson-Voyzey, E., Jaffrani, N., Jager, F., Jain, M., James, M., Jamon, Y., Jang, S. W., Pereira Jardim, C. A., Jarmukli, N., Jeanfreau, R., Jenkins, R., Jiang, X., Jiang, H., Jiang, T., Jiang, N., Jimenez, J., Jobe, R., Joffe, I., Johansson, B., Jones, N., Moura Jorge, J. C., Jouve, B., Jundi, M., Jung, W., Jung, B. C., Jung, K. T., Kabbani, S., Kabour, A., Kafkala, C., Kajiwara, K., Kalinina, L., Kampus, P., Kanda, J., Kapadia, S., Karim, A., Karolyi, L., Kashou, H., Kastrup, A., Katsivas, A., Kaufman, E., Kawai, K., Kawajiri, K., Kazmierski, J., Keeling, P., Kerfes, G. A., Kerr Saraiva, J. F., Ketova, G., Khaira, A., Khalid, M., Khludeeva, E., Khripun, A., Kim, D. I., Kim, D. K., Kim, N. H., Kim, K. S., Kim, Y. -H., Kim, J. B., Kim, J. S., Kinova, E., Klein, A., Kleinschnitz, C., Kmetzo, J., Kneller, G. L., Knezevic, A., Koch, S., Koenig, K., Angela Koh, S. M., Kohrmann, M., Koons, J., Korabathina, R., Korennova, O., Koschutnik, M., Kosinski, E., Kovacic, D., Kowalczyk, J., Koziolova, N., Kragten, J. A., Krause, L. U., Kreidieh, I., Krenning, B. J., Krishnaswamy, K., Krysiak, W., Kuck, K. -H., Kumar, S., Kumler, T., Kuniss, M., Kuo, J. -Y., Kuppers, A., Kurrelmeyer, K., Kwan, T., Kyo, E., Labovitz, A., Lacroix, A., Lam, A., Lanas Zanetti, F. T., Landau, C., Landini, G., Lang, W., Larsen, T. B., Laske, V., Lavandier, K., Law, N., Lee, M. H., Lee, D., Leitao, A., Lejay, D., Lelonek, M., Lenarczyk, R., Leprince, P., Lequeux, B., Leschke, M., Ley, N., Li, Z., Li, Y., Li, X., Li, W., Liang, J., Lieber, I., Lillestol, M., Limon Rodriguez, R. H., Lin, H., Lip, G., Litchfield, J., Liu, Z., Liu, X., Liu, Y., Liu, F., Liu, W., Llamas Esperon, G. A., Llisterri, J. L., Lo, T., Lo, E., Lobos, J. M., Lodde, B. -P., Loiselet, P., Lopez-Sendon, J., Lorga Filho, A. M., Lori, I., Luo, M., Lupovitch, S., Lyrer, P., Zuhairy, H. M., Ma, C., Ma, G., Ma, H., Madariaga, I., Maeno, K., Magnin, D., Mahmood, S., Mahood, K., Maid, G., Mainigi, S., Makaritsis, K., Maldonado Villalon, J. A., Malhotra, R., Malik, A., Mallecourt, C., Mallik, R., Manning, R., Manolis, A., Mantas, I., Manzur Jattin, F. G., Marcionni, N., Marin, F., Santana, A. M., Martinez, J., Martinez, L., Maskova, P., Hernandez, N. M., Matskeplishvili, S., Matsuda, K., Mavri, A., May, E., Mayer, N., Mazon, P., Mcclure, J., Mccormack, T., Mcgarity, W., Mcguire, M., Mcintyre, H., Mclaughlin, P., Mclaurin, B., Medina Palomino, F. A., Mehta, P., Mehzad, R., Meinel, A., Melandri, F., Mena, A., Meno, H., Menzies, D., Metcalf, K., Meyer, B., Miarka, J., Mibach, F., Michalski, D., Michel, P., Chreih, R. M., Mikdadi, G., Mikhail, M., Mikus, M., Milicic, D., Militaru, C., Miller, G., Milonas, C., Minescu, B., Mintale, I., Miralles, A., Mirault, T., Mistry, D., Mitchell, G., Miu, N. V., Miyamoto, N., Moccetti, T., Mohammed, A., Nor, A. M., Molina de Salazar, D. I., Molon, G., Molony, D., Mondillo, S., Mont, L., Moodley, R., Moore, R., Ribeiro Moreira, D. A., Mori, K., Moriarty, A., Morka, J., Moschos, N., Mota Gomes, M. A., Mousallem, N., Moya, A., Mugge, A., Mulhearn, T., Muller, J. -J., Muresan, C. M., Muse, D., Musial, W., Musumeci, F., Nadar, V., Nageh, T., Nair, P., Nakagawa, H., Nakamura, Y., Nakayama, T., Nam, K. -B., Napalkov, D., Natarajan, I., Nayak, H., Nechvatal, L., Neiman, J., Nerheim, P., Neuenschwander, F. C., Nishida, K., Nizov, A., Novikova, T., Novo, S., Nowalany-Kozielska, E., Nsah, E., Nunez Fragoso, J. C., Nyvad, O., de Los Rios Ibarra, M. O., O'Donnell, M., O'Donnell, P., D. J., Oh, Y. S., Oh, Daniel Oh, C. T., O'Hara, G., Oikonomou, K., Olalla, J. J., Olivari, Z., Oliver, R., Olympios, C., Osborne, J., Osca, J., Osman, R., Osunkoya, A., Padanilam, B., Panchenko, E., Pandey, A. S., Vicenzo de Paola, A. A., Paraschos, A., Pardell, H., Park, H. W., Park, J. S., Parkash, R., Parker, I., Parrens, E., Parris, R., Passamonti, E., Patel, J., Patel, R., Pentz, W. H., Persic, V., Perticone, F., Peters, P., Petkar, S., Pezo, L. F., Pham, D., Cao Phai, G. P., Phlaum, S., Pineau, J., Pineda-Velez, A., Pini, R., Pinter, A., Pinto, F., Pirelli, S., Pivac, N., Pizzini, A. M., Pocanic, D., Calin Podoleanu, C. G., Polanczyk, C. A., Polasek, P., Poljakovic, Z., Pollock, S., Polo, J., Poock, J., Poppert, H., Porro, Y., Pose, A., Poulain, F., Poulard, J. -E., Pouzar, J., Povolny, P., Pozzer, D., Pras, A., Prasad, N., Prevot, S., Protasov, K., Prunier, L., Puleo, J., Pye, M., Qaddoura, F., Quedillac, J. -M., Raev, D., Rahimi, S., Raisaro, A., Rama, B., Ranadive, N., Randall, K., Ranjith, N., Raposo, N., Rashid, H., Raters, C., Rauch-Kroehnert, U., Rebane, T., Regner, S., Renzi, M., Reyes Rocha, M. A., Reza, S., Ria, L., Richter, D., Rickli, H., Rickner, K., Rieker, W., Rigo, F., Ripoll, T., Fonteles Ritt, L. E., Roberts, D., Pascual, C. R., Briones, I. R., Reyes, H. R., Roelke, M., Roman, M., Romeo, F., Ronner, E., Ronziere, T., Rooyer, F. A., Rosenbaum, D., Roth, S., Rozkova, N., Rubacek, M., Rubalcava, F., Rubanenko, O., Rubin, A., Borret, M. R., Rybak, K., Sabbour, H., Morales, O. 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A., Spinar, J., Sprigings, D., Spyropoulos, A., Stakos, D., Steinberg, A., Steinwender, C., Stergiou, G., Stites, H. W., Stoikov, A., Strasser, R., Streb, W., Styliadis, I., Su, G., Su, X., Suarez, R. M., Sudnik, W., Sueyoshi, A., Sukles, K., Sun, L., Suneja, R., Svensson, P., Ziekenhuis, A., Szavits-Nossan, J., Taggeselle, J., Takagi, Y., Takhar, A., Tallet, J., Tamm, A., Tanaka, S., Tanaka, K., Tang, A., Tang, S., Tassinari, T., Tayama, S., Tayebjee, M., Tebbe, U., Teixeira, J., Tesloianu, D. N., Tessier, P., The, S. H. K., Thevenin, J., Thomas, H., Timsit, S., Topkis, R., Torosoff, M., Touze, E., Traissac, T., Trendafilova, E., Troyan, B., Tsai, W. K., Tse, H. F., Tsutsui, H., Tsutsui, T., Tuininga, Y. S., Turakhia, M., Turk, S., Turner, W., Tveit, A., Twiddy, S., Tytus, R., Ukrainski, G., Valdovinos Chavez, S. B., Van De Graaff, E., Vanacker, P., Vardas, P., Vargas, M., Vassilikos, V., Vazquez, J., Venkataraman, A., Verdecchia, P., Vester, E. 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J, Zimmermann, S, Zimmermann, R, Zukerman, L, and Zwaan van der, C
Subjects: Male, oral anticoagulation, Internationality, Middle Aged, registry, Antithrombins, Dabigatran, Stroke, Cross-Sectional Studies, Fibrinolytic Agents, Humans, Female, atrial fibrillation, Prospective Studies, Registries, Cardiology and Cardiovascular Medicine, Aged, Atrial Fibrillation
Abstract: Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non–vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients’ baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score ≥2; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701)
Published: 2017

31. Does temperature-confounding control influence the modifying effect of air temperature in ozone-mortality associations?

Author: Chen, K. Wolf, K. Hampel, R. Stafoggia, M. Breitner, S. Cyrys, J. Samoli, E. Andersen, Z.J. Bero-Bedada, G. Bellander, T. Hennig, F. Jacquemin, B. Pekkanen, J. Peters, A. Schneider, A. Breitner, S. Cyrys, J. Hampel, R. Hennig, F. Hoffmann, B. Kuhlbusch, T. Lanzinger, S. Peters, A. Quass, U. Schneider, A. Wolf, K. Diapouli, E. Elefteriadis, K. Katsouyanni, K. Samoli, E. Vratolis, S. Ellermann, T. Ivanovic-Andersen, Z. Loft, S. Massling, A. Nordstrøm, C. Aalto, P.P. Kulmala, M. Lanki, T. Pekkanen, J. Tiittanen, P. Yli-Tuomi, T. Cattani, G. Faustini, A. Forastiere, F. Inglessis, M. Renzi, M. Agis, D. Basagaña, X. Jacquemin, B. Perez, N. Sunyer, J. Tobias, A. Bero-Bedada, G. Bellander, T. UF&HEALTH Study Group
Abstract: Background: Recent epidemiological studies investigating the modifying effect of air temperature in ozone-mortality associations lack consensus as how to adjust for nonlinear and lagged temperature effect in addition to including an interaction term. Methods: We evaluated the influence of temperature confounding control on temperature-stratified ozone-mortality risks in a time series setting in eight European cities and 86 US cities, respectively. To investigate potential residual confounding, we additionally incorporated next day's ozone in models with differing temperature control. Results: Using only a categorical variable for temperature or only controlling nonlinear effect of low temperatures yielded highly significant ozone effects at high temperatures but also significant residual confounding in both regions. Adjustment for nonlinear effect of temperature, especially high temperatures, substantially reduced ozone effects at high temperatures and residual confounding. Conclusions: Inadequate control for confounding by air temperature leads to residual confounding and an overestimation of the temperature-modifying effect in studies of ozone-related mortality. © 2018 The Authors. Published by Wolters Kluwer Health
Published: 2018

32. Relationship between destination affect and intention to visit: the case of destination dislike

Author: Renzi, M. F., Loureiro, S. M. C., Toni, M., Panchapakesan, P., and Kathy Hamilton, Matthew Alexander, Spiros Gounaris, Maria Karampela and Ewelina Lacka
Subjects: Loyalty, Ciências Sociais::Economia e gestão [Domínio/Área Científica], Destination affect, Tourism
Abstract: This paper builds on consumer-brand relationships with an application in the destination context. By analysing the main theoretical contributions, we propose a model in order to shed light on the antecedents of Destination Loyalty in two countries: Portugal and Italy. A proposed model has been tested through a quantitative survey, by administering a questionnaire to an Italian and a Portuguese sample. The two samples were selected consistently with the proportions (in terms of gender and age) of in each city population. The PLS approach was employed to test the model with a twofold objective: assessing the adequacy of the measurements by evaluating the reliability of the individual measures and the discriminant validity of the constructs; appraising the structural model. Although the majority of the hypotheses have been confirmed for both the samples, our findings underline differences among the two nationalities and proposes further field of investigations. info:eu-repo/semantics/acceptedVersion
Published: 2018

33. Low-level air pollution and natural cause mortality in Rome

Author: Danielle Vienneau, Giulia Cesaroni, Bert Brunekreef, Renzi M, de K, Stafoggia M, Klompmaker J, Andersen Z, Forastiere F, and Rodopolou S
Subjects: Global and Planetary Change, Epidemiology, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, Air pollution, medicine, Environmental science, medicine.disease_cause, Water resource management, Land use regression, Pollution, Natural (archaeology)
Published: 2019
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34. Association between particulate matter and cause-specific mortality in five Italian Regions

Author: Viegi G, Cernigliaro A, Stafoggia M, Gariazzo C, Bisceglia L, Ottone M, Claudia Galassi, Renzi M, Forastiere F, and Michelozzi P
Subjects: Global and Planetary Change, Epidemiology, business.industry, Health, Toxicology and Mutagenesis, Association (object-oriented programming), Environmental health, Public Health, Environmental and Occupational Health, Cause specific mortality, Medicine, Particulates, business, Pollution
Published: 2019
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35. Edoxaban versus warfarin in patients with atrial fibrillation

Author: Robert P. Giugliano, Christian T. Ruff, Eugene Braunwald, Sabina A. Murphy, Stephen D. Wiviott, Jonathan L. Halperin, Albert L. Waldo, Michael D. Ezekowitz, Jeffrey I. Weitz, Jind?ich ?pinar, Witold Ruzyllo, Mikhail Ruda, Yukihiro Koretsune, Joshua Betcher, Minggao Shi, Laura T. Grip, Shirali P. Patel, Indravadan Patel, James J. Hanyok, Michele Mercuri, Elliott M. Antman, Braunwald E, Antman EM, Giugliano RP, Ruff CT, Morin SE, Hoffman EB, Murphy SA, Deenadayalu N, Grip L, Mercuri M, Lanz H, Patel I, Curt V, Duggal A, Hanyok J, Davé J, Morgan D, Choi Y, Shi M, Jin J, Xie J, Crerand W, Kappelhof J, Maxwell W, Skinner M, Patel S, Betcher J, Selicato G, Otto C. Jr, Reissner C, Smith K, Ostroske J, Ron A, Giugliano R, Connolly S, Camm J, Ezekowitz M, Halperin J, Waldo A, Paolasso E, Aylward P, Heidbuchel H, Nicolau JC, Goudev A, Roy D, Weitz J, Corbalán R, Yang Y, Botero R, Bergovec M, Ŝpinar J, Grande P, Hassager C, Voitk J, Huikuri H, Nieminen M, Blanc JJ, LeHeuzey JY, Mitrovic V, Alexopoulos D, Sotomora G, Kiss R, SomaRaju B, Lewis B, Merlini P, Metra M, Koretsune Y, Yamashita T, García Castillo A, Ophuis T, White H, Atar D, Horna M, Babilonia N, Ruzyllo W, Morais J, Dorobantu M, Ruda M, Ostojic M, Duris T, Dalby A, Chung N, Zamorano JL, Juul Möller S, Moccetti T, Chen SA, Sritara P, Oto A, Parkhomenko A, Senior R, Verheugt F, Skene A, Anderson J, Bauer K, Easton JD, Goto S, Wiviott S, Lowe C, Awtry E, Berger CJ, Croce K, Desai A, Gelfand E, Goessling W, Greenberger NJ, Ho C, Leeman DE, Link MS, Norden AD, Pande A, Rost N, Ruberg F, Silverman S, Singhal A, Vita JA, Vogelmann O, Gonzalez C, Ahuad Guerrero R, Rodriguez M, Albisu J, Rosales E, 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McLaurin B, Lack A, Mega J, Marti J, Meholick A, Skinner J, Mehrle A, Wall J, Mendelson R, Cervellione K, Mercado A, Cajulis C, Michlin B, Romero Colon J, Milas J, Sanders D, Miller R, Sanchez S, Miller S, Gryczan J, Mody F, Strugatsky S, Moran J, Garner S, Morledge J, Bowman B, Mouhaffel A, Parrott N, Mounsey P, Schuler C, Mowdy M, Todd S, Mullen P, Raziano S, Murphy A, Oehmann V, Nadar V, Parker A, Naidu J, West M, Nallasivan M, Goza J, Nguyen T, Nomanee S, Nielsen R, Wilmot M, Oberoi M, Thakkar N, Oppenheimer K, McCormick J, Orchard R, Garcia L, Osborne J, Gonzalez M, Oza S, Joseph L, Patnam S, Dennison K, Pavon H, Gorry N, Pearlstein R, Montayne S, Pentz W, Duncan D, Peters P, Chacon L, Petruzziello F, Morlando F, Pettis K, Brown F, Pezzella S, Kirk D, Poulathas A, Cush S, Pratt R, Neeper L, Pribble A, Lowe K, Pudi K, Sham L, Pugeda J, Ebert J, Quadrel M, Rafla E, Quinlan E, Reed C, Quinn J, Hemmen C, Rama P, Domingo D, Redondo V, Wroblewski J, Renzi M, Stanley E, Richwine R, Pazier P, Riofrio K, Braun D, Robinson J, Cherrico M, Roehll W, Hollihan P, Rosado, Barnhorst M, Rosado J, Bamhorst M, Rosen R, Martin C, Ross S, Freeman R, Ruoff G, Nelson T, Sacco J, Ball E, Samal A, Schomburg J, Sandberg J, Lafave J, Savin V, Clifton R, Schaefer S, Fekete A, Schneider R, Schneider W, Schulman D, Mercer S, Seals A, Ullig T, Holt A, Seide H, Mather N, Shah G, Witt P, Shalaby A, Seese M, Shanes J, Fleets J, Shaoulian E, Hren A, Sheikh K, Hengerer T, Shih H, Browning J, Shoukfeh M, Stephenson L, Siler T, Champagne M, Simpson P, Meyer R, Singh N, Turner K, Singh V, Nelson M, Skierka R, Hughes B, Keene R, Smith R, Hodnett P, Spangenthal S, Thomason L, Sperling M, Vasquez E, Spivack E, McCartney P, Staniloae C, Liu M, Steljes A, Cox C, Struble R, Vittitow T, Suresh D, Frost J, Swerchowsky V, Freemyer D, Szulawski I, Herwehe S, Tahirkheli N, Springer K, Takata T, Bruton T, Talano J, Leo L, Tami L, Corchado D, Tatarko M, Swauger M, Tawney K, Dastoli K, Teague S, Young K, Tee H, Mitchell T, Teixeira J, Southam D, Torres M, Tucker P, Salas L, Updegrove J, Hanna K, Val Mejias J, Harrelson KG, Vemireddy D, Cardoza T, Verma S, Parsons T, Vicari R, Warren K, Vijay N, Washam M, Vossler M, Kilcup S, Walsh R, Renaud K, Ward S, Locklear T, Waxman F, Sanchez G, Weiss R, St Laurent B, Westcott J, Williams D, Gibson C, Williams R, Dowling C, Willis J, VonGerichten S, Wood K, Capasso Gulve E, Worley S, Pointer S, Yarows S, Sheehan T, Yasin M, Yi J, Dongas B, Yousuf K, Zakhary B, Curtis S, Zeig S, Mason T, Zellner C, Harden M, Roper E, Waseem M, Grammer M., PERRONE FILARDI, PASQUALE, Cardiovascular Division (SZG), Brigham and Women's Hospital [Boston], Mount Sinai Medical Center, Icahn School of Medicine at Mount Sinai [New York] (MSSM), University Hospitals Case Medical Center (CLEVELAND - UHCMC), University Hospitals Case Medical Center, Jefferson Medical College (JMC), Thomas Jefferson University Hospitals, Thrombosis and Atherosclerosis Research Institute (TARI), McMaster University [Hamilton, Ontario], University Hospital Brno, Institute of Cardiology (WARSAW - Cardiology), Institute of Cardiology, Cardiology Research Center (MOSCOU - CRC), Cardiology Research Center, National Hopital Organization (OSAKA - NHO), Osaka National Hospital, Université de Brest (UBO), Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Graduate School, Endocrinology, ACS - Amsterdam Cardiovascular Sciences, Cardiology, Nursing, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, General Internal Medicine, Giugliano, Rp, Ruff, Ct, Braunwald, E, Murphy, Sa, Wiviott, Sd, Halperin, Jl, Waldo, Al, Ezekowitz, Md, Weitz, Ji, Špinar, J, Ruzyllo, W, Ruda, M, Koretsune, Y, Betcher, J, Shi, M, Grip, Lt, Patel, Sp, Patel, I, Hanyok, Jj, Mercuri, M, Antman, Em, Comi, Giancarlo, ENGAGE AF TIMI 48, Investigators, Robert P., Giugliano, Christian T., Ruff, Eugene, Braunwald, Sabina A., 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Grammer, M.
Subjects: Male, Pyridines, [SDV]Life Sciences [q-bio], Embolism, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, chemistry.chemical_compound, 0302 clinical medicine, Edoxaban, Atrial Fibrillation, MESH: Double-Blind Method, 030212 general & internal medicine, MESH: Warfarin, Stroke, MESH: Aged, MESH: Middle Aged, Cardiovascular diseases [NCEBP 14], Hazard ratio, General Medicine, MESH: Follow-Up Studies, Middle Aged, 3. Good health, MESH: Atrial Fibrillation, Cardiovascular Diseases, Anesthesia, Cardiology, Female, Adult, Aged, Anticoagulants, Double-Blind Method, Follow-Up Studies, Hemorrhage, Humans, Thiazoles, Warfarin, MESH: Hemorrhage, Andexanet alfa, medicine.drug, medicine.medical_specialty, MESH: Enoxaparin, MESH: Anticoagulants, MESH: Stroke, Dabigatran, 03 medical and health sciences, Internal medicine, medicine, MESH: Kaplan-Meier Estimate, Rivaroxaban, MESH: Humans, business.industry, MESH: Cardiovascular Diseases, MESH: Adult, medicine.disease, Confidence interval, MESH: Male, chemistry, business, MESH: Female, MESH: Embolism
Abstract: Contains fulltext : 125374.pdf (Publisher’s version ) (Open Access) BACKGROUND: Edoxaban is a direct oral factor Xa inhibitor with proven antithrombotic effects. The long-term efficacy and safety of edoxaban as compared with warfarin in patients with atrial fibrillation is not known. METHODS: We conducted a randomized, double-blind, double-dummy trial comparing two once-daily regimens of edoxaban with warfarin in 21,105 patients with moderate-to-high-risk atrial fibrillation (median follow-up, 2.8 years). The primary efficacy end point was stroke or systemic embolism. Each edoxaban regimen was tested for noninferiority to warfarin during the treatment period. The principal safety end point was major bleeding. RESULTS: The annualized rate of the primary end point during treatment was 1.50% with warfarin (median time in the therapeutic range, 68.4%), as compared with 1.18% with high-dose edoxaban (hazard ratio, 0.79; 97.5% confidence interval [CI], 0.63 to 0.99; P
Published: 2013
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36. The role of Social Media in Tourist Experience

Author: Toni, M, Di Pietro, L, Guglielmetti Mugion, R, Renzi, M. F., D.E.Im. Università degli Studi della Tuscia, Toni, M, Di Pietro, L, Guglielmetti Mugion, R, and Renzi, M. F.
Published: 2016

37. Impact of Spontaneous Extracranial Bleeding Events on Health State Utility in Patients with Atrial Fibrillation: Results from the ENGAGE AF‐TIMI 48 Trial

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Corredor, M., Rivera Rodriguez, E., Manzur, F., Builes, A., Jaramillo Munoz, C., Delgado, P., Hernandez, H., Aldana Diaz, I., Fernandez Ruiz, R., Arroyave, C., Delgado Restrepo, J., Leon Pineda, L., Cano, N., Accini, M., Accini, J., Zhang, Y. L., Zhou, S. X., Li, B. G., Zheng, Z. Q., Wang, J. Q., Zhao, X. L., Han, R. J., Zhao, R. P., Kang, H., Zhang, Z., Lin, Y. N., Zhang, H. Q., Qiang, H., Yuan, Z. Y., Li, L. L., Yu, B., Xu, Y. P., Yin, Y. H., Gao, M., Zheng, Y., Zheng, X., Yang, Y. J., Li, A. Y., Yang, K., Liang, Y. Z., Xu, Y. M., Gu, J. Y., Xu, J. H., Li, Y. E., Wu, S. L., Huang, D., Wei, M., Shi, X. J., Wang, G. P., Qi, S. Y., Wang, D. M., Yang, Z. Y., Ma, S. M., Lu, Z. H., Liu, L., Gu, X. J., Liao, D. N., Liu, Y., Li, Z. Q., Liu, B., Li, W. M., Kong, Y. Q., Li, T. F., Liu, H., Li, L., Qu, Z., Jiang, X. J., Qiu, Y., Hong, L., You, Z. G., Hong, K., Zhang, P., Fu, G. S., Feng, C., Dong, Y. G., Zhang, X., Chen, X. P., Xie, X. D., Chen, J. Z., Xu, G. L., Bai, F., Grandon Azua, M., Yovaniniz, P., Lara Lara, C., Stockins, B., Campisto, Y., Zapata Staub, J., Potthoff, S., Torres Carrasco, G., Pincetti, C., Carmona Perez, M., Opazo, M., Romero Llamas, R., Martinez, D., Manriquez Silva, L., Manriquez, L., Rebolledo, C., Lopetegui, M., Arratia Diaz, P., Florenzano, F., Parada, A., Corbalan, R., Obreque, C., Cobos, J., Mondaca Mondaca, P., Bugueno, C., Retamal Matus, L., Balboa, W., Mabee, J., Woodford, T., Caterini, T., Wharton, S., Morley, A., Wahby, R., Giesbrecht, L., Velthuysen, G., Teitelbaum, J., Teitelbaum, I., Tremblay, M., Talbot, P., David, D., Talajic, M., Bobbie, C., Syan, G., Kailey, P., Sussman, J., St-Hilaire, R., Silverio, G., Shu, D., Marchand, C., Rupka, D., Bozek, B., Ricci, J., Nethercott, C., Qureshi, A., Mercado, A., Cervellione, K., Mendelson, R., Turri, L., Polasek, P., Sardin, V., Pesant, Y., Carroll, L., Parkash, R., Bolton, R., O'Mahony, W., Banville, P., O'Hara, G., Nicholson, R., Lamoureux, U., Najarali, A., Krider, J., Mucha, M., Roth, M., Morrison, D., Morely, A., Mawji, A., Studenikow, E., Maranda, C., Vaillancourt, T., Malette, P., Matthews, J., MacCallum, C., Seib, M., Ma, P., Douglas, S., Luton, R., Roberts, P., Lichtenstein, T., Lam, H., Lam, S., St-Germain, L., Lainesse, A., Dewar, C., Labonte, R., Roy, M., Kouz, S., Perkins, L., Huynh, T., Standring, R., Hoag, G., Ho, V., Ho, K., Scott, L., Heath, J., Hatheway, R., Houbraken, D., Viau, C., Fortin, C., Zondag, M., Eikelboom, J., Dufresne, M., Kubanska, A., du Preez, M., Denis, I., Coutu, B., Masson, C., Costi, P., Gauthier, M., Constance, C., Valley, S., Cleveland, D., Vansickle, L., Chilvers, M., Lepage, C., Chehayeb, R., Otis, J., Cha, J., Hundseth, M., Bose, S., Stafford, C., Bhargava, R., Antle, S., Archibald, J., Manoylov, E., Kitova, M., Tzekova, M., Tumbeva, D., Tumbev, H., Nyagina, M., Todorov, G., Momchilova-Lozeva, D., Staneva, A., Vasilev, I., Popov, A., Milusheva, T., Petranov, S., Kostov, K., Pencheva, G., Vasilev, D., Nikolov, F., Stoyanovski, V., Mincheva, V., Miteva, B., Mihov, A., Manolova, A., Kamenova, P., Hergeldjieva, V., Kinova, E., Goudev, A., Kostova, E., Georgiev, B., Wall, J., Gergova, V., Donova, T., Milcheva, N., Denchev, S., Parishev, G., Chompalova, B., Zimmermann, E. Burger, Zimmermann, S., Almeida, M., Boas, F. Villas, Lustosa, E., Sobral Filho, D., Carraro, A., Simoes, M., Vicente, C., Saraiva, J., do Val, R., Sampaio, R., Pagnan, L. Goncalves, dos Santos, F. Rossi, Rodrigues, D., Rodrigues, A., Rocha, M. Rubia, Rodrigues, L., Barros, R., Rocha, J., Leipelt, J., Katz Weiand, L. Reis, Avellar, K., Reis, G., Gozalo, A., Almeida, J. Pimenta, Luiz, R. Osorio, Leaes, P., Morales, K., Sebba Barroso de Souza, W. Kunz, Radaelli, G., Kalil, C., Almeida, A., Kaiser, S., Cury, C., Jorge, J., Pereira, L., Jaeger, C., Ninho, L., Guimaraes, A., Gomes, A., Gomes, M., Pereira, G., Gagliardi, R., Daitz, C., Finimundi, H., Araujo, E., Ferreira, L., Seroqui, M., Saporito, W. Faustino, Morgado, S., Dutra, O., Laimer, R., Duda, N., Pereira, V., De Patta, M., Barroso, D., Costantini, C., Silva, J., Chaves Junior, H., Fleck, N., Brondani, R., Cunha, S., Botelho, R., Sehnem, E., Precoma, D. Bertolim, Ferraz, R. Franchin, Alves da Costa, F. Augusto, Motta, C., Atie, J., de Melo, R. Ferreira, Lotufo, P. Andrade, Coutinho, E., Vincenzo de Paola, A. Amato, Denie, D., Wollaert, B., Beerts, C., Vrolix, M., Mestdagh, I., Vervoort, G., van Welden, J., Vanwelden, J., Derycker, K., Vandekerckhove, Y., Jacobs, C., Mehrle, A., Skinner, J., Meholick, A., Marti, J., Mega, J., Lack, A., Stockman, D., Huyberechts, D., Scavee, C., Clinckemaille, N., Parque, J., Raepers, M., Mairesse, G., Malmendier, D., Herzet, J., Meeusen, K., Heidbuchel, H., Tincani, G., Desfontaines, P., De Bruyne, L., De Tollenaere, M., de Koning, K., De Bleecker, J., Banaeian, F., Capiau, L., O'Shea, V., Szto, G., Perrett, L., Purnell, P., Batta, C., Paul, V., Li, J., McKeirnan, M., Morrison, H., Wright, J., Wright, A., Chung, A., Watkin, R., Gilchrist, M., Venkataraman, A., Lehman, R., Jones, S., Gates, P., Flecknoe-Brown, S., Silver, G., Davis, S., Kay, S., Dart, A., Slattery, A., Crimmins, D., Price-Smith, S., Colquhoun, D., Hoffmann, B., Arstall, M., Paraskevaidis, T., Anderson, C., Morell, Y., Vico, M., Teves, M., Sosa Liprandi, M., Morara, P., Severino, P., Buzzetti, C., Schygiel, P., Walker, M., Turner, W., Bridge, C., Storey, R., Goloboulicz, A., Schmidberg, J., Kennard, S., Sopher, M., McLaurin, B., Young, G., Kwong, Winghan J., Antman, Elliott M., Ruff, Christian T., Wang, J. H., Iriarte, M., Morissette, A., Wang, Kaijun, Li, Haiyan, and Yalcin, R.
Subjects: Male, medicine.medical_specialty, Complications, Time Factors, Pyridines, Health Status, Embolism, Hemorrhage, Arrhythmias, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Risk Factors, Surveys and Questionnaires, Internal medicine, Atrial Fibrillation, Humans, Medicine, In patient, Prospective Studies, 030212 general & internal medicine, anticoagulation, Blood Coagulation, Original Research, Aged, Aged, 80 and over, Quality and Outcomes, business.industry, Anticoagulants, Atrial fibrillation, Middle Aged, bleeding, medicine.disease, Stroke, Thiazoles, Treatment Outcome, quality of life, utility, Physical therapy, Cardiology, Female, Warfarin, Gastrointestinal Hemorrhage, Cardiology and Cardiovascular Medicine, business, TIMI, Health Services and Outcomes Research, Factor Xa Inhibitors
Abstract: Background The impact of different types of extracranial bleeding events on health‐related quality of life and health‐state utility among patients with atrial fibrillation is not well understood. Methods and Results The ENGAGE AF ‐ TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation–Thrombolysis in Myocardial Infarction 48) Trial compared edoxaban with warfarin with respect to the prevention of stroke or systemic embolism in atrial fibrillation. Data from the EuroQol‐5D ( EQ ‐5D‐3L) questionnaire, prospectively collected at 3‐month intervals for up to 48 months, were used to estimate the impact of different categories of bleeding events on health‐state utility over 12 months following the event. Longitudinal mixed‐effect models revealed that major gastrointestinal bleeds and major nongastrointestinal bleeds were associated with significant immediate decreases in utility scores (−0.029 [−0.044 to −0.014; P P =0.001], respectively). These effects decreased in magnitude over time, and were no longer significant for major nongastrointestinal bleeds at 9 months, but remained borderline significant for major gastrointestinal bleeds at 12 months. Clinically relevant nonmajor and minor bleeds were associated with smaller but measurable immediate impacts on utility (−0.010 [−0.016 to −0.005] and −0.016 [−0.024 to −0.008]; P Conclusions All categories of bleeding events were associated with negative impacts on health‐state utility in patients with atrial fibrillation. Major bleeds were associated with relatively large immediate decreases in utility scores that gradually diminished over 12 months; clinically relevant nonmajor and minor bleeds were associated with smaller immediate decreases in utility that persisted over 12 months. Clinical Trial Registration URL: https://www.clinicaltrials.gov/ . Unique identifier: NCT00781391.
Published: 2017
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38. A different approach to limit the pollutants’ emissions of agricultural engines

Author: Bietresato, M, Renzi, M, and Mazzetto, F
Published: 2017

39. SORVEGLIANZA INTEGRATA DELLA LEISHMANIOSI CANINA IN EMILIA-ROMAGNA

Author: Santi, Annalisa, Galletti, Giorgio, A, Procopio, Rugna, Gianluca, Renzi M, Romanelli C, Nardo, Di, Albieri, Alessandro, Bellini, Romeo, Lombardini A, Natalini S, M, Sabatino, Cagarelli R, Carra E, Calzolari, Mattia, Varani, Stefania, and Tamba, Marco
Published: 2017
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40. Anthropogenic impacts on the Orbetello lagoon ecosystem

Author: Focardi, S., Mariottini, M., Renzi, M., Perra, G., Focardi, S. E., Focardi, Silvia, M., Mariottini, Renzi, M, G., Perra, and Silvano, Focardi
Subjects: Pollution, Health, Toxicology and Mutagenesis, media_common.quotation_subject, Toxicology, Gas Chromatography-Mass Spectrometry, remote sensing, Biomonitoring, Hydrocarbons, Chlorinated, Animals, Humans, Seawater, Water Pollutants, Ecosystem, POPs, Environmental quality, media_common, Pollutant, Eels, Water Pollution, Pesticide Residues, Public Health, Environmental and Occupational Health, Organochlorine pesticide, Pesticide, POP, Polychlorinated Biphenyls, biomonitoring, European eel, Italy, Thematic Mapper, Environmental chemistry, Environmental science
Abstract: The aim of the present study was to assess the environmental quality of Orbetello lagoon (Tyrrhenian coast, Italy), using a biomonitoring method based on measuring organochlorinated pollutants in the Anguilla anguilla, chosen as sentinel organism, and remote sensing data obtained by elaboration of Landsat 7 Enhanced Thematic Mapper (ETM) data of 2002. Polychlorinated biphenyls and organochlorine pesticides were determined by gas chromatography/mass spectrometry in muscle of European eels captured in seven sites having different levels of pollution in Orbetello lagoon. Remote sensing data and chemical analysis showed the Albegna river as a probable vehicle of pesticides (hexachlorocyclohexanes).
Published: 2009
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41. Association between air pollution and venous thromboembolism

Author: Davoli M, Michelozzi P, Stafoggia M, Solimini A, Forastiere F, and Renzi M
Subjects: Global and Planetary Change, medicine.medical_specialty, Epidemiology, business.industry, Health, Toxicology and Mutagenesis, Public Health, Environmental and Occupational Health, Air pollution, medicine.disease_cause, Pollution, Emergency medicine, medicine, Time series study, business, Venous thromboembolism
Published: 2019
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42. A nationwide study of particulate matter and daily hospitalizations for respiratory diseases in Italy

Author: Michelozzi P, Davoli M, Forastiere F, Viegi G, Maio S, Gariazzo C, Renzi M, and Stafoggia M
Subjects: Global and Planetary Change, Epidemiology, business.industry, Health, Toxicology and Mutagenesis, Environmental health, Public Health, Environmental and Occupational Health, Medicine, Respiratory system, Particulates, business, Pollution
Published: 2019
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43. Short-term association between daily PM2.5 and PM10 concentrations and cardiovascular admissions in Italy – a national approach

Author: Gariazzo C, Salvatore Fasola, Viegi G, Michelozzi P, Stafoggia M, M. Davoli, Renzi M, and Forastiere F
Subjects: Global and Planetary Change, Epidemiology, business.industry, Health, Toxicology and Mutagenesis, Environmental health, Public Health, Environmental and Occupational Health, Medicine, business, Association (psychology), Pollution, Term (time)
Published: 2019
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44. Application of macroinvertebrates ecological indicators and functional descriptors to monitor the impact of fish farming in a Mediterranean coastal lagoon

Author: Marini, G., D'Aversa, E., Mazzotta, L., Franco, A., Oroscopi, F., Renzi, M., VILELLA, Sebastiano, PINNA, Maurizio, Gideon Hulata, Marini, G., D'Aversa, E., Mazzotta, L., Franco, A., Oroscopi, F., Renzi, M., Vilella, Sebastiano, and Pinna, Maurizio
Subjects: Aquiculture impacts, coastal lagoons, benthic macroinvertebrates, ecological indicators
Abstract: Coastal and transitional water ecosystems are amongst the most productive and valuable ecosystems on Earth. For their ecological characteristics they have been largely used for fish farming. The lagoons, in particular, are also important as nursery habitats for fishes and for their role in supporting the economically valuable fishes stocks. Fish farming affects the environmental quality with risks of eutrophication, which can lead to the destruction of the same stock bred and to severe anoxic conditions. Such changes in the physical and chemical characteristics in the sediment can have a strong impact on the structure of the benthic macroinvertebrate communities. Therefore, this work deals with the evaluation of the impact of cage rearing of Sparus aurata, farmed at low and high density, in a Mediterranean coastal lagoon located in Apulia (South Italian coastline). Here the changes in macroinvertebrates community structure and in most common ecological indicators were analyzed. Sediment samples were collected with a box-corer between November 2014 and February 2015 at five stations of the lagoon: two located nearly the cage rearing (high density and low density of S. aurata) while three control sites were located at increasing distance from the rearing cages in areas not impacted by fish farming. In parallel, 75 leaf-bags were submerged in the same five stations (15 leaf-bags per site) and retrieved after 5, 15, 30, 60 and 90 days of exposure. At each sampling occasion, some physical-chemical parameters (temperature, conductivity, pH, dissolved O2, salinity, TDS) were also recorded. Macroinvertebrates collected from box-corer and leaf-bags were identified at lowest possible level and following ecological indicators AMBI, M-AMBI, BENTIX and BITS were calculated. The most evident changes of cage rearing were a significant effect on benthic macroinvertebrate community and an accumulation of nutrients in the sediments of the stations directly interested by fish farming.
Published: 2015

45. Chlamydiae in corvid birds

Author: DI FRANCESCO, ANTONIETTA, DONATI, MANUELA, BALBONI, ANDREA, GALUPPI, ROBERTA, SALVATORE, DANIELA, Laroucau, K, Merialdi, G, Renzi, M., Di Francesco, A, Donati, M, Laroucau, K, Balboni, A, Galuppi, R, Merialdi, G, Salvatore, D, and Renzi, M
Subjects: birds, Chlamydiae
Published: 2015

46. Outcomes With Edoxaban Versus Warfarin in Patients With Previous Cerebrovascular Events Findings From ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48)

Author: Pan, Y. F., Lim, G., Desire, A., Tseng, W. K., Rost, Natalia S., Grammer, M., Khetarpal, S., Waseem, M., Zellner, C., Roper, E., Amin, M., Harden, M., Sababathi, R., Valpas, S., Bourlios, P., Kawaguchi, A., Mavronasiou, E., Pandurangi, U., Shams, S., Dichristin, U., Purayil, M. Padinhare, Munemasa, M., Angel, J., Gurusamy, P., Berni, A., Platner, N., Zeltser, D., El Jarroudi, M., Kisos, D., Haruna, T., Bernhardt, P., Coisne, D., Nakahara, Y., Li, W. M., Karamitsos, C., Tziortziotis, A., Essop, M., Nunkoo, T., Gani, M., Wilson, L., Kelfkens, Y., Mitha, I., Taljaard, J., Naidoo, D., Duki, Y., Snyders, F., Munnik, M., Soma, P., Johnston, H., Patki, N., Jasani, B., Van Der Merwe, N., Goosen, Y., Van Zyl, L., Le Roux, M., Venter, T., Wessels, L., Bae, H. J., Han, M. G., Cha, J. K., Kim, D. H., Cho, B. R., Ryu, D. R., Choi, H. H., Hong, K. S., Chung, W. S., Oh, Y. S., Han, S. H., Lee, K. H., Hong, T. J., Lee, H. W., Hyon, M. S., Jung, J. W., Jeon, H. K., Lee, J. M., Kang, D. H., Choi, K. J., Kim, C. J., Jin, E. S., Kim, D. S., Seo, J. S., Kim, H. S., Cha, M. J., Kim, J. T., Park, M. S., Kim, J. H., Park, J. H., Kim, J. S., Parekh, P., Vicente, C., Simoes, M., Carraro, A., Sobral Filho, D., Lustosa, E., Boas, F. Villas, Almeida, M., Zimmermann, S., Zimmermann, E. Burger, Kunkelova, V., Berka, L., Brodova, P., Bar, M., Bergovec, M., Vrazic, H., Matsushita, C., Premchand, R., Boyer, M., Bakliza, Z., Sutalo, K., Kirner, D., Steiner, R., Cvitkusic Lukenda, K., Samardzic, P., Buksa, B., Kartsagkoulis, E., Kaplan, P., Sopher, M., Young, G., Senior, R., Roberts, J., Mackin, A., Moriarty, A., Olympios, C., Green, M., Shandra, T., Zhurba, S., Logvinov, Y., Zharinov, O., Mudruk, I., Yena, L., Nahrebetskyy, V., Kraiz, I., Chompalova, B., Parishev, G., Kharalkar, H., Knezevic, A., Denchev, S., Usan, N., Kraydashenko, O., Milcheva, N., Stets, R., Donova, T., Gergova, V., Georgiev, B., Kostova, E., Goudev, A., Jaksic Jurinjak, S., Kinova, E., Hergeldjieva, V., Yagensky, A., Kamenova, P., Manolova, A., Vasilev, I., Mihov, A., Miteva, B., Kupnovytska, I., Mincheva, V., Jelic, V., Stoyanovski, V., Makar Ausperger, K., Nikolov, F., Vasilev, D., Pencheva, G., Kostov, K., Petranov, S., Boriani, G., Milusheva, T., Popov, A., Staneva, A., Momchilova-Lozeva, D., Francetic, I., Todorov, G., Nyagina, M., Tumbev, H., Tumbeva, D., Tzekova, M., Kitova, M., Manoylov, E., Dicker, D., Giovannelli, F., Archibald, J., Antle, S., Bhargava, R., Stafford, C., Bose, S., Hundseth, M., Cha, J., Otis, J., Romic, I., Ferri Certic, J., Chehayeb, R., Lepage, C., Tusek, S., Ciglenecki, N., Jeric, M., Chilvers, M., Car, S., Carevic, V., Vansickle, L., Kyyak, Y., Serik, S., Cleveland, D., Valley, S., Constance, C., Gauthier, M., Lasri, E., Costi, P., Masson, C., Coutu, B., Denis, I., du Preez, M., Kubanska, A., Dufresne, M., Krider, J., Eikelboom, J., Zondag, M., Fortin, C., Viau, C., Houbraken, D., Hatheway, R., Mabee, J., Bagatin, J., Lizogub, V., Atar, S., Heath, J., Scott, L., Ho, K., Perdomo Mejia, I., Ho, V., Hoag, G., Standring, R., Huynh, T., Perkins, L., Kouz, S., Roy, M., Labonte, R., Fuki, Y., Dewar, C., Lainesse, A., St-Germain, L., Lam, S., Lam, H., Lichtenstein, T., Roberts, P., Luton, R., Douglas, S., Sanchez Vallejo, G., Ma, P., Seib, M., MacCallum, C., Matthews, J., Malette, P., Vaillancourt, T., Maranda, C., Studenikow, E., Mawji, A., Morely, A., Morrison, D., Roth, M., Mucha, M., Volkov, V., Goncharov, O., Vizir, V., Sklyanna, O., Vatutin, M., Drapchak, I., Vakaliuk, I., Dharmarao, A., Zanwar, I., Thakur, B., Vinod, M. 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Subjects: Male, medicine.medical_specialty, Pyridines, medicine.medical_treatment, 030204 cardiovascular system & hematology, Brain Ischemia, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Double-Blind Method, Recurrence, Edoxaban, Internal medicine, Atrial Fibrillation, parasitic diseases, Secondary Prevention, medicine, Humans, Myocardial infarction, cardiovascular diseases, Stroke, Aged, Advanced and Specialized Nursing, business.industry, Hazard ratio, Warfarin, Anticoagulants, Atrial fibrillation, Thrombolysis, Middle Aged, medicine.disease, nervous system diseases, Thiazoles, Treatment Outcome, chemistry, Anesthesia, Cardiology, Female, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery, TIMI, medicine.drug
Abstract: Background and Purpose— Patients with atrial fibrillation and previous ischemic stroke (IS)/transient ischemic attack (TIA) are at high risk of recurrent cerebrovascular events despite anticoagulation. In this prespecified subgroup analysis, we compared warfarin with edoxaban in patients with versus without previous IS/TIA. Methods— ENGAGE AF-TIMI 48 (Effective Anticoagulation With Factor Xa Next Generation in Atrial Fibrillation-Thrombolysis in Myocardial Infarction 48) was a double-blind trial of 21 105 patients with atrial fibrillation randomized to warfarin (international normalized ratio, 2.0–3.0; median time-in-therapeutic range, 68.4%) versus once-daily edoxaban (higher-dose edoxaban regimen [HDER], 60/30 mg; lower-dose edoxaban regimen, 30/15 mg) with 2.8-year median follow-up. Primary end points included all stroke/systemic embolic events (efficacy) and major bleeding (safety). Because only HDER is approved, we focused on the comparison of HDER versus warfarin. Results— Of 5973 (28.3%) patients with previous IS/TIA, 67% had CHADS 2 (congestive heart failure, hypertension, age, diabetes, prior stroke/transient ischemic attack) >3 and 36% were ≥75 years. Compared with 15 132 without previous IS/TIA, patients with previous IS/TIA were at higher risk of both thromboembolism and bleeding (stroke/systemic embolic events 2.83% versus 1.42% per year; P P P P =0.02). No treatment subgroup interactions were found for primary efficacy ( P =0.86) or for intracranial hemorrhage ( P =0.28). Conclusions— Patients with atrial fibrillation with previous IS/TIA are at high risk of recurrent thromboembolism and bleeding. HDER is at least as effective and is safer than warfarin, regardless of the presence or the absence of previous IS or TIA. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00781391.
Published: 2016

47. Cardioversion of Atrial Fibrillation in ENGAGE AF-TIMI 48

Author: Seibert, H., Bolton, R., Florian, J., Nyman, K., Viitaniemi, J., Maenpaa, A., Laheaar, M., Lucijanic, T., Lappalainen, T., Jakala, P., Valpas, S., Hussi, E., Kaarleenkaski, S., Huikuri, H., Ratnik, E., Vahula, V., Rosenthal, A., Voitk, J., Paumets, M., Rivis, L., Laane, E., David, D., Kolk, R., Stern, A., Kaik, J., Serup-Hansen, K., Wiggers, H., Jakobsen, U., Torp-Pedersen, C., Svenningsen, A., Sand, N., Raae, D., Raymond, I., Petrovic, V., Overgaard, K., Olsen, R., Nielsen, H., Veng-Olsen, T., Iversen, H., Madsen, H., Ibsen, H., Loof, A., Hassager, C., Christensen, L., Christensen, H., Dodt, K., Zidkova, E., Samkova, D., Vodnansky, P., Labrova, R., Spinar, J., Spacek, R., Slaby, J., Reichert, P., Jirsova, E., Podrazil, P., Pisova, J., Havlova, I., Petrova, I., Peterka, K., Olsr, J., Nechanicky, R., Melichar, M., Krocova, E., Machova, V., Ludka, O., Kvasnicka, J., Kuchar, R., Kovar, P., Kosek, Z., Kostkova, G., Kochrt, M., Kobza, R., Jirmar, R., Jerabek, O., Jelinek, Z., Jarkovsky, P., Jandik, J., Hubac, J., Honkova, M., Gregor, P., Eikelboom, J., Krider, J., Dufresne, M., Kubanska, A., du Preez, M., Talbot, P., Denis, I., Coutu, B., Masson, C., Costi, P., Gauthier, M., Constance, C., Valley, S., Cleveland, D., Vansickle, L., Chilvers, M., Lepage, C., Chehayeb, R., Otis, J., Cha, J., Hundseth, M., Bose, S., Stafford, C., Bhargava, R., Antle, S., Archibald, J., Manoylov, E., Kitova, M., Tzekova, M., Tumbeva, D., Tumbev, H., Nyagina, M., Todorov, G., Momchilova-Lozeva, D., Staneva, A., Vasilev, I., Popov, A., Milusheva, T., Petranov, S., Kostov, K., Pencheva, G., Vasilev, D., Nikolov, F., Stoyanovski, V., Mincheva, V., Miteva, B., Mihov, A., Manolova, A., Kamenova, P., Hergeldjieva, V., Kinova, E., Goudev, A., Kostova, E., Georgiev, B., Gergova, V., Donova, T., Milcheva, N., Denchev, S., Parishev, G., Chompalova, B., Zimmermann, E. 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Rostasne, Palinkas, A., Nagy, A., Kolumban, E., Merkely, B., Kiss, K., Medvegy, M., Kiss, T., Matoltsy, A., Karakai, H. Horvathne, Lupkovics, G., Kovacs, Z., Baranyai, M., Kovacs, I., Koczka, M., Jakal, A., Kiss, R., Feil, J. Felfoldine, Kis, E., Kosztyu, M., Kanakaridisz, N., Varga, A., Fiok, J., Szatmari, J., Edes, I., Muskoczki, E., Dioszeghy, P., Almaraz, S. Padilla, Camas, L. Velasquez, Guerra, L., Samayoa, C. Sanchez, Pozuelos, J. Mayen, Sanchez, M., Estrada, M. Rodas, Guevara, S., Lavagnino, A. Ovando, Jimenez, T., Melgar, I. Guzman, Ramirez, V. de Leon, Milla, O. 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G., Bouzo, M., Sehr, B., Beyer-Westendorf, J., Vierbeck, S., Berrouschot, J., Dichristin, U., Bernhardt, P., Wurow, A., Al-Zoebi, A., Duprat, C., Roudaut, R., Leparree, S., Poulard, J., Corbut, S., Kacet, S., Deruche, E., Hermida, J., Arfaoui, M., Dinanian, S., El Jarroudi, M., Decoulx, E., Berger, N., Coisne, D., Dias, P., Blanc, J., Talajic, M., Berbari, H., Belhassane, A., Boyer, M., Babuty, D., Boursin, P., Amarenco, P., El Jarroudi, F., Agraou, B., Le Heuzey, J., Nappila, H., Virtanen, V., Salminen, O., Rasi, H., Sankari, T., Fortin, C., Gilchrist, M., Zondag, M., Dewar, C., Lainesse, A., Roth, M., Viau, C., St-Germain, L., Mucha, M., Lam, S., Lam, H., Lichtenstein, T., Roberts, P., Luton, R., Douglas, S., Ma, P., Seib, M., MacCallum, C., Matthews, J., Malette, P., Vaillancourt, T., Maranda, C., Studenikow, E., Mawji, A., Morely, A., Morrison, D., Nicholson, R., Venkataraman, A., Walker, M., Lamoureux, U., Wright, L., Ebano, P., Storey, R., Price, R., Pye, M., Flint, L., Newby, D., Andrews, A., Murdoch, D., Helliwell, L., Blagden, M., MacCallum, P., Kennard, S., Sopher, M., Young, G., Senior, R., Brown, R., Lip, G., Najarali, A., Dunn, S., More, R., Isted, C., Maxwell, T., Jones, D., Standring, R., Hoag, G., Marazzi, P., McGhee, C., Ho, V., Ho, K., Scott, L., MacLeod, M., O'Hara, G., Heath, J., Finlayson, M., Hatheway, R., Beeton, I., Linker, N., Wright, J., Wright, A., Chung, A., Watkin, R., Atkinson, C., Houbraken, D., Lindsay, S., Turner, W., Ramasamy, V., Lie, F., Avery, D., Bridge, C., Douglas, H., D'Costa, D., Wilmott, R., Duff, J., Huynh, T., Camm, J., Perkins, L., Kouz, S., Roy, M., Labonte, R., Choy, A., Davies, D., Chapman, O., Dougal, K., and Yalcin, R.
Published: 2016

48. Spatial and temporal extent of monitoring water column and seabed habitats indicators, based on their scales of natural variation

Author: Renzi, M., Cozzoli, F., Alemany, F., Arvanitidis, C., Balbín, R., Beken, C., Bojanic, N., Boicenco, L., Cardigos, F., Deudero, S., Giannoudi, L., Yebra, L., Lazar, L., López Jurado, J. L., Mercado, J., Moncheva, S., Pagou, K., Pérez Ruzafa, A., Quetglas, A., Reizopoulou, S., Ruiz, J., Shtereva, G., Simboura, N., Slabakova, V., Streftaris, N., Stefanova, K., PINNA, Maurizio, BASSET, Alberto, Tübitak, MAM, Renzi, M., Cozzoli, F., Alemany, F., Arvanitidis, C., Balbín, R., Beken, C., Bojanic, N., Boicenco, L., Cardigos, F., Deudero, S., Giannoudi, L., Yebra, L., Lazar, L., López Jurado, J. L., Mercado, J., Moncheva, S., Pagou, K., Pérez Ruzafa, A., Pinna, Maurizio, Quetglas, A., Reizopoulou, S., Ruiz, J., Shtereva, G., Simboura, N., Slabakova, V., Streftaris, N., Stefanova, K., and Basset, Alberto
Subjects: Marine Framework Strategy Directive, seabed habitat integrity, biodiversity, eutrophication
Abstract: The Marine Framework Strategy Directive (MFSD, 2008/56/EC) aims for clean, healthy and productive marine ecosystems within all the EU Members states. The MFSD promotes an holistic, ecosystem based approach to marine conservation and monitoring (Art. 13) Monitoring strategies should: 1) focus on the potential of scale dependence in the observed dynamics and 2) be able to integrate the effect of mediating factors operating at different scale levels. However, present knowledge on spatial and temporal fluctuations in marine ecosystems is scarce. The boundaries of natural variation of several important marine ecosystem processes are still undefined. A major source of complexity is the fact that ecosystem processes are occurred across different spatial as well as temporal scales. The present knowledge gap results in uncertainty on the selection of measured parameters and the definition of sampling frequency and sites. Hereby, we discuss theoretical and applied issues related to definition of optimal cross-scale monitoring strategies. Literature data and existing databases were analyzed, to define the connectivity across nested scales of principal D1 (Biodiversity), D5 (Eutrophication), D6 (Seabed habitat integrity) MFSD descriptors. We conclude that present monitoring strategy does not completely fulfil the scaling issues due to lack of theoretical knowledge on cross-scale processes and poor coordination across monitoring operators. A stronger cooperation among member states and regional environmental agencies is needed to implement efficient cross-scale environmental monitoring. This research was developed by partners of the Integrated Regional monitoring Implementation Strategy in the South European Seas (IRIS-SES, http://iris-ses.eu) Project, a pilot project on new knowledge for an integrated management of human activities in the sea (PP/ENV D2/SEA 2012), funded by the European Union.
Published: 2014

49. Existing monitoring of Mediterranean sea: a gap analysis

Author: Cozzoli, F., Renzi, M., Alemany, F., Arvanitidis, C., Balbín, R., Beken, C., Bojanic, N., Boicenco, L., Cardigos, F., Deudero, S., Giannoudi, L., Yebra, L., Lazar, L., López Jurado, J. L., Mercado, J., Moncheva, S., Pagou, K., Pérez Ruzafa, A., Quetglas, A., Reizopoulou, S., Ruiz, J., Shtereva, G., Simboura, N., Slabakova, V., Streftaris, N., Stefanova, K., PINNA, Maurizio, BASSET, Alberto, Cozzoli, F., Renzi, M., Alemany, F., Arvanitidis, C., Balbín, R., Beken, C., Bojanic, N., Boicenco, L., Cardigos, F., Deudero, S., Giannoudi, L., Yebra, L., Lazar, L., López Jurado, J. L., Mercado, J., Moncheva, S., Pagou, K., Pérez Ruzafa, A., Pinna, Maurizio, Quetglas, A., Reizopoulou, S., Ruiz, J., Shtereva, G., Simboura, N., Slabakova, V., Streftaris, N., Stefanova, K., and Basset, Alberto
Subjects: Marine Strategy Framework Directive, marine monitoring programs, biological features, physicochemical features, pressures, impacts, indicators, threshold
Abstract: The Marine Strategy Framework Directive (2008/56/EC) of the European Parliament and of the Council (17th June 2008) establishes a framework for community action in the field of marine environmental policy. A crucial issue will be to improve the existing marine monitoring programs to cover the MSFD requirements. The comparison and identification of gaps in the existent national monitoring is a first step to include new parameters and frequencies of observation according to all relevant Directives and specially to MSFD. Our report is a first, integrated, cross-state assessment of the present state of Mediterranean monitoring networks. Data on monitoring stations have been provided from all member states of IRIS-SES + Croatia and joint in a unique georeferenced dataset. We used the cross-classification to build contingency tables of the counts at each combination of factor levels. Distances from coastline, densities of sampling stations, spatial overlap across descriptors, were also reported. As main results, we observed a large heterogeneity across MS on the parameters measured for each descriptors, on the density of sampling stations and on the frequency of sampling. Larger gaps have been identified for the descriptors Mammals, Birds, Reptiles (D1, D4, D6), Litter (D10), Energy & Noise (D11). The outputs from this work will be included into a GIS planning tool (Activity 3) including many scales and levels on which the MSFD Directive has been built on, such as the characteristics level (e.g. biological features, physicochemical features), pressure and impact, indicator/threshold, spatial (location of monitoring stations) and temporal (frequency-periodicity) across regions-subregions-countries.
Published: 2014

50. Recent changes in macroalgae distribution patterns in the Orbetello lagoon (Italy)

Author: Giovani A., Mari E., Specchiulli A., Focardi S. E., Renzi M., Giovani, A., Mari, E., Specchiulli, A., Focardi, S. E., and Renzi, M.
Subjects: Macroalgae, Chlorophyta, Rhodophyta, Transitional water, Trophic level
Abstract: 1 - This study related recent distribution changes in seven macroalgae taxa (Acetabularia acetabulum, Chaetomorpha linum, Cladophora sp., Gracilariopsis longissima, Spyridia sp., Ulva laetevirens, Valonia aegagrophyla) to spatial (basin) and temporal (time) trophic differences in a meso-eutrophic Mediterranean coastal lagoon (Orbetello, Italy). 2 - In July 2003 and July 2009, the coverage percentage (CP) of each considered taxon was measured in 38 stations equally distributed in the Western and Eastern lagoon basins. All data were analysed using SURFER v8.0 software along with ANOVA, ANOSIM and multivariate analyses to produce geostatistical spatial distribution maps and to estimate statistical probabilities for "basin" and "time" factors. 3 - Data from this study were integrated with data on phanerogams reported by Giovani et al. (2010) to evaluate changes occurring at a functional group level from 2003-2009 using the Ecological Evaluation Index (EEI). 4 - Observed macroalgae changes may have been due to lagoon management activities performed during the study period. The removal of direct nitrate inputs seems to have forced specie-specific shifts that were highly significant only in the Western basin. 5 - Statistically significant differences at the taxon level have been indicated for Spyridia sp. (basin and time) and Cladophora sp. (time) taxa. Other non-significant changes included a rarefaction of Chaetomorpha linumin the Western basin and Spyridia sp. in the Eastern basin, and an increase of Gracilariopsis longissima, C. linum and Valonia aegagrophyla in the Eastern basin. 6 - EEI application indicated a general improvement in water quality due to management measures applied in Western basin, whereas the Eastern basin evidences stability/slight degradation from 2003-2009.
Published: 2014

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