1. A case of thrombotic microangiopathy and acute demyelinating central nervous system lesions as the first manifestation of systemic lupus erythematosus
- Author
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R. A. Higgoda, B. G. Premaratne, W. Dissanayake, D. R. Chamara, K. D. Ellepola, and I. K. Jayasinghe
- Subjects
Altered consciousness ,medicine.medical_specialty ,Thrombotic microangiopathy ,business.industry ,Encephalomyelitis ,Central nervous system ,Thrombotic thrombocytopenic purpura ,medicine.disease ,Dermatology ,medicine.anatomical_structure ,immune system diseases ,hemic and lymphatic diseases ,medicine ,Organ involvement ,Microangiopathic haemolytic anaemia ,skin and connective tissue diseases ,Demyelinating Disorder ,business - Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder with a relapsing and remitting course and multi- organ involvement which can present with a wide range of neuropsychiatric manifestations. Acute disseminating encephalomyelitis (ADEM) is an autoimmune demyelinating disorder of the central nervous system (CNS). Thrombotic thrombocytopenic purpura (TTP) is a medical emergency which manifests with microangiopathic haemolytic anaemia (MAHA), thrombocytopenia and neurological abnormalities and is known to be a rare association of SLE. We report a case of a 14 year old female who presented with fever and altered consciousness, subsequently diagnosed to have SLE with thrombotic microangiopathy and acute demyelinating CNS lesions in an ADEM-distribution
- Published
- 2021
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