1. Comparative study of fluoride bioavailability following the administration of sodium fluoride alone and in combination with different calcium salts
- Author
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P. D'Aranda, B. Duplan, Marie-Claire Chapuy, Monique E. Arlot, Quillet P, P. J. Meunier, and D. Briancon
- Subjects
inorganic chemicals ,Adult ,Male ,Endocrinology, Diabetes and Metabolism ,chemistry.chemical_element ,Dentistry ,Biological Availability ,Absorption (skin) ,Calcium ,Pharmacology ,chemistry.chemical_compound ,Pharmacokinetics ,Sodium fluoride ,Humans ,Orthopedics and Sports Medicine ,Drug Interactions ,Volunteer ,Calcium salts ,business.industry ,technology, industry, and agriculture ,Middle Aged ,Bioavailability ,body regions ,chemistry ,Sodium Fluoride ,Drug Therapy, Combination ,Female ,business ,Fluoride - Abstract
To assess whether an interval of a few hours would be advisable between an intake of sodium fluoride (NaF) and that of calcium salts when treating osteoporotic patients with vertebral collapse, we carried out three pharmacokinetic studies in 12 healthy fasting volunteer subjects to compare the fluoride bioavailability provided by NaF alone and NaF combined with two calcium salts. The results were as follows: (1) When NaF is accompanied by calcium, the fluoride peak level is lower and delayed. (2) Fluoride absorption varied greatly among individuals in both experiments, but none of the 6 subjects proved to be nonabsorbers. (3) The areas under the curves obtained with each of the three preparations were not significantly different, but 24-h urinary fluoride was significantly lower in volunteers receiving simultaneously NaF and calcium salts than in volunteers receiving only NaF.
- Published
- 1990