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Мета. Дослідження кулінарних властивостей та збереженість різних сортів картоплі і зміна їх під час зберігання. Методи: лабораторний, метод математичної статистики. Результати. На формування смаку впливає вміст компонентів хімічного складу. Встановлено, вміст компонентів хімічного складу бульб картоплі залежать від сортових особливостей. Вміст сухих речовин у бульбах коливався від 19,4 % у сорту Бернадетте до 20,8 % у Курас, вміст крохмалю 14,2–17,1 % відповідно. Після очищення в бульбах втрачається сухих речовин на 20–22 % від їх вмісту. Визначена комплексна оцінка кулінарних властивостей сортів картоплі та їх зміни під час зберігання. На початку зберігання в середньому картопля мала 13,6 % очисток. Найбільше їх було у сорту Курас (16,3 %), сорт Бернадетте з мілкими вічками мав найменшу кількість очисток (12,4 %). За період зберігання картоплі кількість очисток в неї збільшувалося до 2,1 % (сорт Курода). Найбільш економічними в цьому виявився сорт Бернадетте (1 %). Восени по збільшенню кількості очисток є сорти Роко (1,7 %), Курас (1,9 %), Беллароза (2,0 %). Вища збереженість спостерігалась у сортів Беллароза та Роко. Вихід товарної продукції був відповідно 93,20 і 91,10 %. Природні втрати маси за період зберігання в середньому у бульб всіх сортів становили 4,22±0,67 %, із них 72,9 % за рахунок випаровування вологи, а 27,1 % – за рахунок дихання. Нижча втрата маси спостерігалась у сорту картоплі Беллароза і становила 3,55 %. У сортів картоплі, що вивчалися втрата маси коливалась з середньою силою, коефіцієнт варіації – 19,5 %. Сенсорні показники, стан м’якуша залежать від особливості сорту. Дослідженням встановлено, смак бульб має сильний кореляційний зв'язок з розвареністю та борошнистістю відповідно (r = 0,87, r = 0, 89). Висновки. Проведена в роботі систематизація досліджених сортів картоплі за призначенням, дозволила відзначити наступні рекомендації: для виробництва продовольчої картоплі можна рекомендувати сорти Беллароза, Роко; для виробництва хрусткої картоплі і сушених картоплепродуктів найбільш придатні сорти Беллароза і Курас; для переробки на крохмаль рекомендуються сорти: Курас; для приготування гарніру для дієтичного харчування сорт картоплі Роко та Бернадетте.

Purpose. Evaluation of the effect of changing the width of the impeller blades on the characteristics of a torque-flow pump. Searching for the optimal blade extension into the free chamber of the pump. A torque-flow pump of the “Turo” type SVN 500/32 was chosen as the subject of the research work. Methodology. A number of numerical experiments were conducted to determine the flow structure in the flowing part of a torque-flow pump. The width of the impeller blade was chosen as a variable. Numerical experiments were carried out using the ANSYS CFX software package. The integral parameters of the researched pump were determined in order to build the integral characteristics. Findings. The structure of the general flow and toroidal vortex was studied and analyzed in the torque-flow pump. A flow model was built in a torque-flow pumps with basic and modernized design. A relationship between the parameters of the pump and the change in the impeller blade width was found. The width of the impeller blade was changed in the range from min = -20 to max = +100 mm. Originality. The paper researched the effect of additional hydraulic losses caused by the mismatch between the center of the toroidal vortex and the edges of the impeller blades on the integral characteristics of the torque-flow pump. Practical value. A significant increase in the operating parameters of the “Turo” type torque-flow pump was achieved with the help of modernization of the impeller design. This allows expanding the range of the pump’s operation. At the same time, it is not required to replace such expensive elements as the pump casing.

The chronic consumption of mycotoxin-contaminated forage tends to the weight loss of young cattle, decreasing the reproductive success of adult animals, milk yield, and tolerance to high temperatures. The aim of this paper was to study the eff ects of the SNP C994G in the CYP3A28 gene on the productive and reproductive characteristics of dairy and beef breeds. Cows were measured by body weight dynamics, exterior, reproduction, milk production traits, bone mineral density, bulls were analyzed estimating their progeny traits. Dairy cows received dietary betaine supplement with the measurement of homocysteine levels. Molecular genetic was performed by PCR-RFLP method. The effects of SNP C994G were shown in relation to the udder size, the constitution and birth weight of Abredin-Angus cows, as well as the fat and protein content of Ukrainian Red-and-White Dairy cows milk. The higher sensitivity of the GG genotype to less homocysteine level after the addition of betaine was shown. Given the identifi ed correspondence, pleiotropic eff ects of CYP3A28 gene can be concluded. A microscopic analysis of forage supported the findings in relation to greater efficiency of the CC genotype under conditions of low mycotoxins contamination, to which CYP3A28 is selective.

Welded arrows are widely used as the main working element of earthmoving equipment. The wide use of such structures makes the task of ensuring their dimensional stability during manufacture urgent. After all, it is precisely the provision of dimensions within the limits of the designer's tolerance that contributes to the functionality of the product and the safety of its operation. It is shown that the optimization of the basing scheme in combination with the use of appropriate technological equipment provides acceptable indicators of dimensional stability

Introduction. Heavy metal pollution of soils in urban areas is a severe problem in many regions of Russia and other countries. The higher concentrations of heavy metals in playground soils represent a severe threat to children’s health. The lack of legislatively approved decisions on periodic monitoring of soil contamination in residential areas and on remediation measures does not ensure a favourable ecological situation in the urban environment. Materials and methods. The mass spectrometry method was used to analyse the gross content of heavy metals and arsenic in playground soils in residential areas of the Industrialny district of Perm in 2019. Results. The assessment of soil contamination with heavy metals and arsenic in the soils of playgrounds of residential areas of the Industrialny district of Perm indicated their unsatisfactory quality. The concentration of arsenic in the soil exceeded the MPC by up to 4.6 times, zinc-2.6 times; nickel-3.5 times; cadmium-1.7 times; copper-1.5 times. The total indicator of contamination of Zс and Zст of the soil corresponds to the permissible level. The level of soil contamination with heavy metals ranges from “low” to “moderate” based on the indicator of potential environmental risk. Limitations. The limitations of the study are related to the small number of soil samples on the territory of playgrounds and one-time sampling, which limits the interpretation of the data obtained to determine trends in soil pollution, as well as the absence of identified patterns of contaminants in soils from different sources of their inflow. Conclusion. The results suggest that it is necessary to monitor soil contamination in residential areas and implement timely remediation measures; it is necessary to make decisions at the legislative level on the soil quality management in residential areas to ensure a favourable ecological environment, taking into account domestic and foreign experience.

Paleotemperature curves for water masses and average annual temperatures were constructed from our own and published data for Central and Eastern Tethys for the Jurassic-Quaternaryfor the first time.

The results of a geochemical study and paleogeographic, paleoclimatic interpretation for a cyclically constructed section of upper Cretaceous deposits near Volsk city, Saratov region, are presented. Elementary formation cyclites and cyclic variations of a number of certain parameters were associated with the Milankovich astronomical-climatic cycles. The curves of changes of paleotemperature, humidity, paleobathymetry were compiled. The results obtained give an idea of the migration of the arid belt boundaries in the upper Cretaceous and the overall climatic zonation, which is important for regional and global paleoclimatic reconstructions, as well as the history of the development of shelf seas that covered the Russian plate (especially Ulyanovsk-Saratov trough). Paleotemperatures of the land surface in the denudation areas are obtained from the chemical index of alteration (CIA). In the Turonian-Campanian interval selected climatic cyclicity, including period of relative cooling (Turonian–Coniacian) with paleotemperature about 20 °С, the period of relative warming in the mid-late Campanian (20–24 °С), the cooling time at the end of the late Campanian (19–21 °С) and the period of warming at the turn of the Campanian and Maastrichtian and in the early Maastrichtian time. In Maastrichtian age, there are two climatic cycles, beginning with a time of relative cooling (about 19 °С) and ending with a time of relative warming (about 20 С, at the end of Maastrichtian to 25 °С). The cycles of climate humidity change are also determined: two cycles in Campanian time, three cycles in early Maastrichtian, and one cycle in late Maastrichtian. The boundary of the early and late Maastrichtian corresponds to the change of arid conditions to humid ones. The paleobatimetry curves show transgressive-regressive cycles: one in the late Turonian-Coniacian time, two in the late Campanian time, five in the early Maastrichtian time, and one in the late Maastrichtian time. Depth variations were estimated: in the Turonian-Coniacian time in the range of 70–80 m, in the Campanian-Maastrichtian time, the paleobatimetry consistently increased and changed from 100 to 200 m (on average about 150 m). The results obtaired give and idea of the migration of the boundaries of the arid belt in the Late Creataceous and main features of the climatic zonation, which is important for regional and global paleoclimatic reconstructions, as well as for the history of the development the Russian plate in the Ulyanovsk-Saratov region.

The results of geochemical research of the cyclic section of the Upper Cretaceous deposits near Staryi Oskol town at Belgorod province and paleogeographical and paleoclimatic interpretation of these data were given for the first time.

Experimental material on the change in the quality of cereal-legume silage with the introduction of the biological product “Fitop 27.83’ is presented. The effect of silos harvested on its basis on the productivity of a dairy herd of cattle is shown. A change in the content of nutrients was established when using this biocomplex.

The current study considered the distribution of trace elements in snow cover taking into account the functional zoning of the territory of Berezniki-Solikamsk industrial hub, Perm Region, Russia. The concentrations of 22 trace elements were determined in the dissolved phase of snowmelt using ICP-MS method. On the basis of on the background approach, it was found that Ni, Se, Cu, and Sn are actively accumulated in the snow cover. Snowmelt surface runoff during snow melting period significantly contributes to the total watershed discharge of rivers; therefore, the compliance with the Russian fishery quality standards was assessed. It was found that meltwater is the source of Cu, Mn, Se, Zn, V in surface waters. Significant concentrations of Pb, Cd, W, As, Se in snow are characteristic of conditionally background sites in comparison with average values of global concentrations of dissolved trace elements in river waters, and Se, W, Pb, Ni, As, Cd are characteristic of all functional zones. This study presented the possible sources of priority pollutants. The greatest technogenic impact was observed in the area of transport infrastructure development. Upon that, recreational and residential functional zones also experience significant anthropogenic impact. In order to create a comfortable and healthy urban environment it is necessary to implement the measures to restore these areas.

Adequate diagnosis and treatment of secondary hemochromatosis in patients with congenital anemias is important for reducing long-term mortality and morbidity as for improving patients' quality of life. Due to the strong migration movements during recent years, the number of patients in Germany suffering from hemoglobinopathies as some of the most relevant disorders in the context of iron overload (IOL) has increased enormously. Many of these patients had received inadequate medical care in their countries of origin prior to migration, including diagnosis and treatment of IOL. In parallel, various medical developments and achievements took place, including the expansion of stem cell transplant as curative therapeutic option and the introduction of gene therapy for patients with hemoglobinopathies. Diagnostic tools to assess both liver and heart IOL became available at more sites in Germany. Overall experience with iron elimination therapy either as monotherapy or as combination of different chelators increased. All these aspects were considered during revision of the consensus-based guideline on the diagnosis and treatment of secondary IOL in patients with congenital anemias (AWMF Reg. No. 025/029). Here, we briefly summarize the procedure for the revision of the guideline, provide a brief overview of innovations as compared to the previous version dated from 2015, and finally present the consensus recommendations adopted in the current version.Eine adäquate Diagnose und Behandlung der sekundären Hämochromatose bei Patienten mit angeborenen Anämien ist wichtig, um die langfristige Mortalität und Morbidität zu senken und die Lebensqualität der Patienten zu verbessern. Durch die starken Migrationsbewegungen der letzten Jahre ist die Zahl der Patienten in Deutschland, die an einer Hämoglobinopathie als einer der wichtigsten Erkrankungen im Zusammenhang mit Eisenüberladung leiden, enorm gestiegen. Viele dieser Patienten wurden in ihren Herkunftsländern vor der Migration nur unzureichend medizinisch versorgt, einschließlich der Diagnose und Behandlung der Eisenüberladung. Parallel dazu gab es verschiedene medizinische Entwicklungen und Errungenschaften, darunter die Ausweitung der Stammzelltransplantation als kurative Therapieoption und die Einführung der Gentherapie für Patienten mit Hämoglobinopathien. An einer zunehmenden Zahl von Standorten in Deutschland wurde die nicht invasive Diagnostik zur Beurteilung der Leber- und Herz-Eisenüberladung eingeführt. Die allgemeine Erfahrung mit der Eiseneliminationstherapie, ob als Monotherapie oder in Form einer Kombination verschiedener Chelatoren, nahm zu. All diese Aspekte wurden bei der Überarbeitung der konsensbasierten Leitlinie zur Diagnose und Behandlung der sekundären Eisenüberladung bei Patienten mit angeborenen Anämien (AWMF Reg. Nr. 025/029) berücksichtigt. Wir fassen hier kurz das Vorgehen bei der Überarbeitung der Leitlinie zusammen, geben einen kurzen Überblick über die Neuerungen im Vergleich zur Vorgängerversion aus dem Jahr 2015 und stellen schließlich die in der aktuellen Version übernommenen Konsensusempfehlungen vor.

The aim of the research is to determine the best sample of chickpeas by a set of characteristics of productivity, content of some components of chemical composition and resistance to diseases and pests. The object of research was 30 samples of seven species of chickpeas - Cicer arietinum L., C. Reticulatum Labizinsky., C. Judaicum Boiss., C. bijugum K.N. Rech., C. Pinnatifidum Jaub., C. chorassinicum (Bge) M. Pop., C. Yamashitae Kitam. collections of the National Center for Plant Genetic Resources of Ukraine (NCGRRU). Based on the results of the values of the objective functions, a ranking series of collection samples of different species of chickpeas is established. Among the 30 collection specimens, the Pegasus (UD0501164) and the Cicerrotundum (UD0500422) have the first rank. The second rank among the samples of the collection have six samples. According to the values of the results of the objective functions, they are arranged in the following order: UDO 500196 , Triumph (UD0501163) , Welfare (UD0501194) UDO 50207 , Luhanets (UD0500102) . The third rank has samples NEC 1506 (UD0501485) , UDO 500001 , NEC 1847 (UD0501486) , Hybrid 25 (UD0500015) , Flip97 – 220с , INIA45 . Among the foreign samples of the collection the highest rank in the samples ICCW 42 (UD0502028) , ICCW 8 (UD0501165) , ICCW 71 (UD0502026) , ICCW 9 (UD0501669) . Samples ICCW 42 (UD0502028), UDO 500022, X2001th 173-18, which have the highest values of protein content in grain: 24.5, 26.8 and 25.7%, respectively. Samples CP 66-1 (UD0500980) and Sierra (UD0501751) have the best oil content in grain: 7.6 and 6.8%, respectively. On the basis of the calculations on the set of features, the sample Cicer rotundum (UD0500422) C. arietinum was evaluated - good level - among the presented collection samples of chickpeas. Samples Pegasus (UD0501164), Dobrobut (UD0501194), Krasnokutsky 123 (UD0500101), UD0502017, NEC 1847 (UD0501486) and UD0500001 of the species C. arietinum were assessed as satisfactory.

Development of a single method for inventory of pollutant emissions from installations based on the elaboration of existing methods for calculation of air pollution is an important scientific and practical task in the field of environmental safety. The main purpose of the study is to test and compare models of stationary emission sources and to assess air quality based on them. In the inventory of pollutant emissions, the following materials are used: direct measurements, which are based on direct instrumental measurements, and calculated measurements or combinations thereof. According to the direct measurements of NOx and CO emissions from the operation of gas turbines at the Valley compressor station with a nominal capacity of 1 to 50 MW, we found that: the actual emissions of NO and CO increase with the average load on the installation and the time of introduction into operation and date of issue and the actual values of the maximum allowable concentration of NOx (from 100.13 to 467 mg / m) and CO (from 16.08 to 444.88 mg / m) do not exceed the permissible levels of NO-500 mg / m and CO-250 mg / m according to the instructional documents. Comparison of these calculation methods showed the same results, which confirms the need for their systematization with the subsequent development of a single methodology. The distance of 106 m, where the maximum concentration of pollution in adverse weather conditions is expected, was obtained by the calculation method of determining the surface concentration of NOx and CO emissions from the installation. To assess the effectiveness of the methods for inventory of pollutant emissions into the atmosphere from gas turbines, we have developed a scheme of relationship between the object being assessed for efficiency and the object being serviced. Particularly noteworthy are the results and analysis of direct measurements of NOx and CO emissions, as well as the developed scheme for linking the inventory process for pollutant emissions into the atmosphere from installations. The actual concentration of pollutants can be estimated by measuring the background, although in this case it is impossible to exclude the influence of other neighboring and remote emission sources on the results of the air pollution assessment. Depending on the specific task, the results of computer simulation for given parameters of the external environment can also be used to assess the actual, retrospective or prospective conditions. Future conditions can be modeled only with the help of computer simulation. The method of air pollutant concentration calculation for emissions of enterprises does not consider all possible features of emission sources and, in terms of passive stationary sources and cold emissions, the algorithm needs to be clarified and the justifications in the paper indicate ways to make these improvements. Inventory is the first stage in the strategy of air quality regulation, as it provides information for the development, justification and decision-making in regulating the activities of gas turbines to reduce adverse effects on the environment and public health.

The research was aimed at studying the formation of the yield level, as well as the quality indicators of winter wheat grain, depending on the studied agricultural practices (the seeding rate, the dose of mineral fertilizers), as well as the suitability of grain for its further processing. The objects of research in the experiment were new varieties of winter wheat of domestic selection: Solnechnaya and Danaya. The highest yield was in the winter wheat varieties Danaya (5 million pieces/ha) and Solnechnaya (5.5 million pieces/ha) with fractional application of nitrogen fertilizers according to the scheme N30+60+30P90K90 kg/ha a.i. It was 6.17 and 5.68 t/ha, respectively. In terms of yield, the Danaya variety is higher than the Solnechnaya variety by 0.49 t / ha. Physico-chemical and technological indicators were the highest with fractional application of nitrogen fertilizers (N30+60+20+10P90K90). Thus, in the winter wheat variety, the solar mass of 1000 grains increased by 4.60 g; nature-by 42 g/l; protein content-by 1.10%; vitreous-by 10%; gluten content - by 8.6%. The grain of the Danaya winter wheat variety was distinguished by physical and chemical parameters. The difference between the varieties was: 5.57 g; 71 g / l; 14%; 1.6%; 8.5%, respectively. Nitrogen fertilizers with their fractional application at a dose of 120 kg / ha d. v. for both varieties increases not only the yield, but also the quality of grain suitable for food, baking and technological purposes.

We present the results of a geochemical study and their paleogeographic and paleoclimatic interpretation for a cyclically constructed section of the Upper Cretaceous deposits near Staryi Oskol in the Belgorod region.

The results of a geochemical, paleogeographic, and paleoclimatic study of a cyclically constructed section of upper Cretaceous deposits near Vol’sk city (Saratov oblast) are presented. Elementary layered cyclites and cyclic variations of several certain parameters were associated with the Milankovich astronomical-climatic cycles. Paleotemperature, humidity, and paleobathymetry curves were compiled. Paleotemperatures of the land surface in the denudation areas were obtained from the chemical index of alteration (CIA). Climatic cyclicity was established in the Turonian–Campanian interval, including a period of relative cooling (Turonian–Coniacian) with a paleotemperature of approximately 20°С, the period of relative warming in the mid–late Campanian (20–24°С), the cooling time at the end of the late Campanian (19–21°С) and the period of warming at the turn of the Campanian and Maastrichtian and in the early Maastrichtian time, there are two climatic cycles in Maastrichtian age, beginning with a time of relative cooling (approximately 19°С) and ending with a time of relative warming (approximately 20°С, at the end of Maastrichtian to 25°С). The cycles of climate humidity change are also determined: two cycles in Campanian time, three cycles in early Maastrichtian, and one cycle in late Maastrichtian. The boundary of the early and late Maastrichtian corresponds to the change of arid conditions to humid ones. The paleobatimetry curves show transgressive–regressive cycles: one in the late Turonian–Coniacian time, two in the late Campanian time, five in the early Maastrichtian time, and one in the late Maastrichtian time. Depth variations were estimated: in the Turonian–Coniacian time in the range of 70–80 m, in the Campanian–Maastrichtian time, the paleobatimetry consistently increased and changed from 100 to 200 m (on average approximately 150 m). These results provide an idea of the migration of the boundaries of the arid belt in the Late Creataceous and main features of the climatic zonation, which is important for regional and global paleoclimatic reconstructions, as well as for the history of the development the Russian Plate in the Ulyanovsk–Saratov region.

The results of the study of the collection of cabbage at the Institute of vegetable and melon growing of the National Agrarian Academy of Sciences of Ukraine are presented. In Ukraine, the most widespread varieties are the varieties of the Central European group, which are valuable samples for breeding for yield and for resistance to head cracking. A collection of cabbage source material is needed to create high-yielding varieties and hybrids of different ripening periods, which are characterized by a high yield of marketable products. The collection contains varieties of white cabbage of early and late maturity, varieties of red cabbage, savoy, Brussels sprouts, cauliflower and kohlrabi. The predominant number of varieties is represented by white cabbage, most of which are varieties of late ripening. It is white cabbage of late ripening varieties that is in greatest demand among the population. It was found that the marketability of heads of early ripening varieties of cabbage was mainly within the range of 80–90 %, and that of the late ripening period ranged from 90 to 100 %. In terms of yield and weight of marketable head of cabbage, late-ripening cabbage varieties exceeded early-maturing ones by 14 %. Plants of early-ripening varieties are small in size: the diameter of the rosette of leaves is not more than 60 cm. Late-ripening varieties in terms of the diameter of the rosette are medium (60–80 cm) or large (over 80 cm). Among the collection specimens of late white cabbage, the greatest breeding value are specimens of the Amager and Biloruska varieties, as well as the red cabbage varieties of the Langeideiker variety. Among the collection specimens of early white cabbage, specimens of varieties Ditmarska rannya and Gollandska rannya are of the greatest breeding value. Among the presented species diversity of cabbage, any species can be a donor of the duration of the growing season.

The article presents the results of the research conducted during the 2015– 2017 years. On the experimental field of the Department of Horticulture and Storage of V.V. Dokuchaev KNAU was determined the influence of the plant growth regulators on the formation of a marketable yield and the content of some components of the cauliflower hybrids chemical composition. The early ripening hybrids of cauliflower Livingstone F1 and Kul F1 were studied. The Humisol-super, Vympel, and Megafol were taken for the study. The experience was a two-factor: factor A was the features of the hybrid, factor B was drug treatment. The repetition was four-fold. Field experiments were carried out according to generally accepted methods. The cauliflowers` soil preparation and the plant care were carried out according to the generally accepted recommendations. Treatment with growth regulators was carried out by spraying plants during the growing season according to the manufacturers' recommendations. The first spraying was carried out after planting seedlings in the open ground; the subsequent spraying had been carried every 14 days. An option without treatment was taken as a control. As a result of the studies, it was found that treatment of cauliflower plants with growth regulators during the growing season significantly affects the yield of hybrids. Over the years of research, the highest yield of the Livingston F1 hybrid was obtained with the Megafol treatment, – 12,9 t/ha (+1,6 t/ha to control). The highest yield of the Kul F1 hybrid was 13,4 t/ha (+1,0 t/ha to control) during Humisol-super treatment. It has been proved that the usage of the growth regulators influenced the physical indicators of the commercial yield of hybrids. During the 2015–2017 years, the average weight of cauliflower heads increased by 2,1–11,8 % compared to the control, depending on the treatment. The Megafol had a greater effect on the hybrids. Plants` treatment with growth regulators increased the average volume of the hybrid head by 1,3–11,3 % compared to the control. In terms of influence on this indicator, Megafol and Humisol-super were the best drugs. It has been established that plant growth regulators affect the components of the cauliflowers' heads' chemical composition. The Vympel and Megafol increased the dry matter content in the Kul F1 hybrid by 1,0 and 1,4 %, respectively, compared with the control. The treatment of plants with the Humisol-super increased the ascorbic acid content in the heads of the Livingston F1 hybrid by 4,3 % compared to the control. It is recommended to apply the treatment of plants during the growing season with Humisol-super (1,5l/ha) and Megafol (2,3 l/ha) every 14 days to increase the yield and improve the physical parameters of cauliflower heads. Key words: cauliflower, hybrids, plant growth regulators, crop yields, physical yield indicators, chemical components.

Introduction Hemangioblastomas are rare, histologically benign, highly vascularized tumors of the brain, the spinal cord, and the retina, occurring sporadically or associated with the autosomal dominant inherited von Hippel-Lindau (VHL) disease. Children or adults with VHL disease have one of > 300 known germline mutations of the VHL gene located on chromosome 3. They are prone to develop hemangioblastomas, extremely rarely starting at age 6, rarely at age 12–18, and, typically and almost all, as adults. There is a plethora of VHL-associated tumors and cysts, mainly in the kidney, pancreas, adrenals, reproductive organs, and central nervous system. Due to a lack of causal treatment, alleviation of symptoms and prevention of permanent neurological deficits as well as malignant transformation are the main task. Paucity of data and the nonlinear course of tumor progression make management of pediatric VHL patients with hemangioblastomas challenging. Methods The Freiburg surveillance protocol was developed by combining data from the literature and our experience of examinations of > 300 VHL patients per year at our university VHL center. Results Key recommendations are to start screening of patients at risk by funduscopy with dilated pupils for retinal tumors with admission to school and with MRI of the brain and spinal cord at age 14, then continue biannually until age 18, with emergency MRI in case of neurological symptoms. Indication for surgery remains personalized and should be approved by an experienced VHL board, but we regard neurological symptoms, rapid tumor growth, or critically large tumor/cyst sizes as the key indications to remove hemangioblastomas. Since repeated surgery on hemangioblastomas in VHL patients is not rare, modern neurosurgical techniques should encompass microsurgery, neuronavigation, intraoperative neuromonitoring, fluorescein dye-based intraoperative angiography, intraoperative ultrasound, and minimally invasive approaches, preceded in selected cases by endovascular embolization. Highly specialized neurosurgeons are able to achieve a very low risk of permanent morbidity for the removal of hemangioblastomas from the cerebellum and spinal cord. Small retinal tumors of the peripheral retina can be treated by laser coagulation, larger tumors by cryocoagulation or brachytherapy. Conclusion We consider management at experienced VHL centers mandatory and careful surveillance and monitoring of asymptomatic lesions are required to prevent unnecessary operations and minimize morbidity.

The purpose of the work is to investigate the effectiveness of the use of physical condition control of students of special medical groups for the development of physical therapy programs. Materials and methods. 40 students of 1st and 2nd year students of National University “Lviv Polytechnic” and Zaporizhzhya State Medical University participated in the experimental studies, which on the basis of the medical examinations were assigned to a special medical group for the presence of diseases of the musculoskeletal system (scoliosis I, II and III degrees). The following methods were used in the research process: analysis and generalization of scientific literature and Internet data; analysis of medical records of students; instrumental methods of morphometric and psychophysiological studies; pedagogical observations; pedagogical experiment of ascertaining orientation; methods of mathematical statistics. The results of the study show that the application of theoretical and methodological provisions and recommendations of corrective measures in the system of test control of physical conditions in students of a special medical group in the practical work, on the basis of integration of specially selected means of physical therapy, enables to activate compensatory mechanisms, mobilize reserve mechanisms ability of the body to increase the competence to perform motor actions, helps to accelerate the formation of knowledge, skills, and elimination of defects motive sphere, eliminating the difference in indicators of psychophysical development between students of the main, preparatory and special medical group. Conclusions. The control of morphofunctional and psychophysiological indicators is an effective mechanism of correction of the physical condition of students of a special medical group with functional disorders of the musculoskeletal system and a necessary prerequisite for the development of complex programs of rehabilitation based on the use of therapeutic exercises.

Цель работы – оценить степень динамического восстановления движений оперированной конечности в течение II периода реабилитации средствами физической терапии у пациентов, которым выполнено эндопротезирование тазобедренного сустава и укрепление капсульно-связочного аппарата полипропиленовой сеткой. Материалы и методы . Проведено ретроспективное исследование историй болезней, рентгенограмм и лабораторных данных 47 пациентов, нуждающихся в восстановлении или укреплении капсулы тазобедренного сустава. Первичное эндопротезирование выполнено у 26 (55,3 %) пациентов, ревизионное – у 21 (44,7 %). Среди пациентов 27 (57,4 %) мужчин и 20 (42,6 %) женщин. Средний возраст пациентов составил 57 лет (от 20 до 86 лет). Результаты. На основе анализа результатов исследования отмечено, что качество жизни пациентов обеих групп, общее субъективное состояние сустава, показатели объема движений оперированной конечности, а также оценка клинико-функциональных результатов лечения по шкале Harris Hip Score (HHS) прямо коррелируют с выполнением предоперационных упражнений терапевтического характера и соблюдением послеоперационной реабилитационной программы физической терапии. Такая корреляция более существенна в срок 12 месяцев после хирургического лечения, через 24 месяца наблюдения показатели состояния оперируемого тазобедренного сустава в обеих группах пациентов существенно не отличались: 65,3 % – группа наблюдения, 52,2 % – группа сравнения через 12 месяцев после операции и 91,3 % и 81,0 % через 24 месяца соответственно. Выводы. Использование полипропиленовой сетки для укрепления задних капсульно-связных структур тазобедренного сустава приводит к расширению функциональных возможностей оперируемой конечности и восстановления пациентов, ускоряет процессы физической реабилитации после выписки из стационара. Доказана целесообразность тщательной предоперационной подготовки пациентов и активного ведения послеоперационного периода (комплексы терапевтических упражнений, информирование пациентов), что позволяет улучшить результаты хирургического и восстановительного лечения, избежать возможных осложнений при условии выполнения рекомендаций и комплексного применения средств физической терапии.

Methotrexate (MTX) is the immunosuppressive anti-inflammatory drug and the antagonist of the enzyme dihydrofolate reductase. Pharmacogenomic studies and clinical evidences suggest that altered response to MTX in patients with different diseases is associated with polymorphisms of genes that regulate folate metabolism. The purpose of the article was to analyze the methotrexate effect on the biochemical indices of psoriasis patients depending on methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms. Effects of two single-nucleotide polymorphisms, C677T and A1298C, were studied. An increase of alanine aminotransferase and aspartate aminotransferase activity above the normal level in the patients with both MTHFR gene polymorphisms after methotrexate intake was observed. In patients with CC, TT, CT genotypes for C677T polymorphism and AA genotype for A1298C polymorphism of MTHFR gene, significant differen­ces in alpha-amylase activity before and after treatment with methotrexate were detected. Analysis of the biochemical indices of patients with arthropathic and vulgaris psoriasis showed that the positive effect of MTX treatment could be associated with wild-type alleles in both polymorphisms of MTHFR gene, while the ineffectiveness of methotrexate was associated with the dihеterozygous genotype. The largest number of smokers was found within the CTAA genotype group (37.5%), while no smokers were observed within TTAA patients and most of CCAA patients. The data obtained testify the utility of the individual approach to the psoriasis patients therapy taking into account genetic background.

Cancers 14(5), 1261 (2022). doi:10.3390/cancers14051261, Published by MDPI, Basel

The results of studies on the influence of weather conditions of the growing season on the formation of the content of some components of the chemical composition and physical properties of Brussels sprouts, as well as methods of packaging on the intensity of its losses during storage are presented. It was found that during storage of Brussels sprouts, weight loss occurs due to a decrease in the content of dry matter, partial evaporation of water, the development of microorganisms and due to drying of the integumentary leaves. Growing season conditions influenced the daily weight loss of Brussels sprouts heads during storage. Weight loss, intensity of water evaporation and development of microorganisms depend on the type of packaging, characteristics of the hybrid and some physical parameters of the cabbage heads. The daily weight loss of unpackaged cabbage heads averaged 0,86–1,02%. The use of inserts made of a film with a thickness of 40 mcm increased the storage time of the heads of Brussels sprouts up to 50 days with daily natural weight loss of 0,05–0,08%. In the structure of natural weight loss of Brussels sprouts, water evaporation accounts for 20,7 to 89,5%. The greatest losses are observed during storage of cabbage in open form – from 85,9 to 89,5%. Packing in polyethylene film reduced water evaporation, so the losses were 53,4–57,2%. Packing 0,5 kg in stretch film contributed to the lowest evaporation losses: 20,7–26,0%. Less intensively affected by diseases are products packed in 1 kg bags in polyethylene film bags with a thickness of 40 mcm. Regression analysis found that the best describes the experimental data of the dependence of GTK and daily weight loss during storage of cabbage in open form and in packing by a polynomial of the second order. When packing 1 kg in a polyethylene film and when using polyethylene liners, this relationship is straightforward.

Hereditary cancer in clinical practice 19(1), 44 (2021). doi:10.1186/s13053-021-00202-0, Published by Springer, Berlin ; Heidelberg

Suitable ex vivo models are required as predictive tools of oromucosal permeability between in vitro characterizations and in vivo studies in order to support the development of novel intraoral formulations. To counter a lack of clinical relevance and observed method heterogenicity, a standardized, controlled and physiologically relevant ex vivo permeation model was established. This model combined the Kerski diffusion cell, process automation, novel assays for tissue integrity and viability, and sensitive LC-MS/MS analysis. The study aimed to assess the effectiveness of the permeation model in the sublingual formulation development of cyclobenzaprine, a promising agent for the treatment of psychological disorders. A 4.68-fold enhancement was achieved through permeation model-led focused formulation development. Here, findings from the preformulation with regard to pH and microenvironment-modulating excipients proved supportive. Moreover, monitoring of drug metabolism during transmucosal permeation was incorporated into the model. In addition, it was feasible to assess the impact of dosage form alterations under stress conditions, with the detection of a 33.85% lower permeation due to salt disproportionation. Integrating the coherent processes of disintegration, dissolution, permeation, and metabolization within a physiological study design, the model enabled successful formulation development for cyclobenzaprine sublingual tablets and targeted development of patient-oriented drugs for the oral cavity.

Aim. The aim of our study was to evaluate the relationship between exogamy degree and lactose assimialation among the population of Eastern Ukraine in the Kharkiv region. Methods. The analysis included information on consumption and assimilation of milk and dairy products by 733 people aged from 14 to 79 years were. Statistical analysis included Shapiro-Wilk test, Pearson fitting (χ2) criterion and Spearman’s correlation analysis. Results. The lactose tolerance (LT) phenotype was found in 69.5%, whereas lactose intolerance (LI) – in 8.8% (from 3.5% to 24.1% in different age groups). In the age group 30-39 years: LI frequency was 24.1% being 2.5-6 times higher than in other groups. The exogamy degree of parents (EDP) showed in the group aged from 30 to 39 years the first EDP was 15.4%, being 1.4-2.5 times less (p = 0,05) than in other groups. Among people with bone marrow disorders the proportion of people with the first and second EDP was 60.9%, being 2.1 to 6.0 times higher than in other groups. Reduced EDP or increased inbreeding level causes the similarity of the chromosomes and affects the density of contact points between them during meiosis, level of recombination can be increased and associated with multifactorial traits. Conclusions. The results can be explained by the effect of the inbreeding level reduction in the presence of a high level of exogamy of parents, which causes high genetic diversity. Keywords: lactose intolerance, lactose tolerance, exogamy degree of parents, single nucleotide polymorphisms 13910C-T and 22018G-A, gene МСМ6.

We present the results of a detailed study of the transversal geochemical zonation in the northern flank of the layered chromitites of the Main Saranovskoe deposit. The precision methods of chemical and mineralogical analysis of the core samples, as well as microprobe studies of chromite grains were used. The primary magmatic two level transverse zonation was established in the ore body. Zonation of the first level is characterized by decrease of Cr2O3 content along with ferrochromite and picrochromite minals, and increase of Al2O3 along with spinel and hercynite minals in the direction from the primary bottom of the ore body to the roof. Zonation of the second level appears as a hidden stratification within the ore body. It is characterized by a sinusoidal change of the component contents in chrome spinel. Magmatic zoning is complicated by the superposition of two processes: 1) metasomatic metamorphism with the release of the secondary chromemagnetite from chromite and origin of chrome chlorite from primary silicates, 2) hydrothermal processes with the formation of uvarovite-calcite veins. The obtained data allowed to detail the process of chromitite generation and to propose a model of ore formation. It supposes two types of stratification in the deposit: rhythmic with formation of ore layers and hidden within ore bodies.

Der Pyruvatkinase(PK)-Mangel der Erythrozyten wird autosomal-rezessiv vererbt und durch Mutationen im PKLR-Gen verursacht. Das Gen kodiert fur das letzte Enzym der anaeroben Glykolyse der Erythrozyten, die Pyruvatkinase (PK-R [Pyruvatkinase-R-Isoform]). Die Folge ist eine nichtautoimmunvermittelte, nichtspharozytare hamolytische Anamie. Dieser Beitrag beleuchtet die klinischen, laborchemischen und molekulargenetischen Charakteristika von Patienten mit PK-Mangel in Deutschland. Mithilfe von standardisierten Fragebogen wurden von den 28 deutschen Patienten mit PK-Mangel, die alle an der PKD Natural History Study teilnahmen, retrospektiv Daten erhoben. Die Patienten wurden auserdem prospektiv uber einen Zeitraum von 2 Jahren beobachtet. Besondere Schwerpunkte wurden auf die Genotyp-Phanotyp-Korrelation sowie die Analyse der Lebensqualitat der Patienten mit PK-Mangel gelegt. Ziel dieses Beitrags ist es, die vielfaltigen klinischen und molekulargenetischen Eigenschaften dieser seltenen Erkrankung darzustellen, um durch eine erhohte Wachsamkeit die Erkrankung fruher zu diagnostizieren und adaquat zu behandeln.

Prussian blue nanozymes possessing peroxidase-like activity gather significant attention as alternatives to natural enzymes in therapy, biosensing, and environmental remediation. Recently, Prussian blue nanoparticles with enhanced catalytic activity prepared by reduction of FeCl3/K3[Fe(CN)6] mixture have been reported. These nanoparticles were denoted as ‘artificial peroxidase’ nanozymes. Our study provides insights into the process of their synthesis. We studied how the size of nanozymes and synthesis yield can be controlled via adjustment of the synthesis conditions. Based on these results, we developed a reproducible and scalable method for the preparation of ‘artificial peroxidase’ with tunable sizes and enhanced catalytic activity. Nanozymes modified with gelatin shell and functionalized with affine molecules were applied as labels in colorimetric immunoassays of prostate-specific antigen and tetanus antibodies, enabling detection of these analytes in the range of clinically relevant concentrations. Protein coating provides excellent colloidal stability of nanozymes in physiological conditions and stability upon long-term storage. © 2022 by the author. Licensee MDPI, Basel, Switzerland. Russian Science Foundation, RSF: 20-75-00029 Funding: This study was supported by the Russian Science Foundation, grant 20-75-00029.

About 75 % of the world’s population loses ability to lactose tolerance in adulthood. The study of tolerance to lactose (LT) or lactase persistence (LP) in Ukrainians is necessary to identify the association of this trait with multifactorial pathologies, the formation of risk groups and food culture development. Theaimof study was to evaluate the genetic aspects of lactose deficiency in population and its relation with human pathologies on the example of a hip fracture. Material and methods:lactose intolerance phenotype was found in 9.7 % of Ukrainians and lactose persistence amounted to 69.4 %. In group of patients with fractures of the proximal femur frequencies were: 13910T – 0.34,13910C – 0.66, 22018A- 0.35, 22018G – 0.65. Distribution of genotypes was 0 % :67.6 % : 32.4 % for TT:CT:CC and 2.9 % : 64.7 % : 32.4 %, for AA:GA:GG. Deviation from the Hardy-Weinberg equilibrium was not observed. Results:when analyzed genotypes for both SNPs, we found the ratio - CTAA:CTGA:CCGA:CCGG being 2.9 % : 61.7 % : 2.9 % : 32.5 %. The linkage disequilibrium was estimated, D’ (r2) for SNPs analyzed was 0.209 (0.554). A half of patients had osteoporosis or osteopenia (n=50.0 %), but these pathologies were not observed in patients with the TTAA genotype. The values BMD of CTGA patients were 4049.8±38.7 and 4109.6±30.0 for CCGG patients. Conclusion:all patients with osteoporosis had a genotype CTGA, average value of BMD was 3795.6±43.8. CTGA-patients had following gastrointestinal tract disorders: gastritis (33.3 %), peptic ulcer (9.5 %), duodenal ulcer (9.5 %), stomach cancer (9.5 %). Heterozygous genotypes significantly increase five times the risk of gastrointestinal pathology in patients with fractures of the proximal femur

About 75 % of the world’s population loses ability to lactose tolerance in adulthood. The study of tolerance to lactose (LT) or lactase persistence (LP) in Ukrainians is necessary to identify the association of this trait with multifactorial pathologies, the formation of risk groups and food culture development.The aim of study was to evaluate the genetic aspects of lactose deficiency in population and its relation with human pathologies on the example of a hip fracture.Material and methods: lactose intolerance phenotype was found in 9.7 % of Ukrainians and lactose persistence amounted to 69.4 %. In group of patients with fractures of the proximal femur frequencies were: 13910T – 0.34,13910C – 0.66, 22018A- 0.35, 22018G – 0.65. Distribution of genotypes was 0 % :67.6 % : 32.4 % for TT:CT:CC and 2.9 % : 64.7 % : 32.4 %, for AA:GA:GG. Deviation from the Hardy-Weinberg equilibrium was not observed.Results: when analyzed genotypes for both SNPs, we found the ratio - CTAA:CTGA:CCGA:CCGG being 2.9 % : 61.7 % : 2.9 % : 32.5 %. The linkage disequilibrium was estimated, D’ (r2) for SNPs analyzed was 0.209 (0.554). A half of patients had osteoporosis or osteopenia (n=50.0 %), but these pathologies were not observed in patients with the TTAA genotype. The values BMD of CTGA patients were 4049.8±38.7 and 4109.6±30.0 for CCGG patients.Conclusion: all patients with osteoporosis had a genotype CTGA, average value of BMD was 3795.6±43.8. CTGA-patients had following gastrointestinal tract disorders: gastritis (33.3 %), peptic ulcer (9.5 %), duodenal ulcer (9.5 %), stomach cancer (9.5 %). Heterozygous genotypes significantly increase five times the risk of gastrointestinal pathology in patients with fractures of the proximal femur, Около 75 % населения мира теряет способность к толерантности к лактозе в зрелом возрасте. Изучение толерантности к лактозе (LT) или лактазной персистенции (LP) у украинцев необходимо для выявления связи этого признака с мультифакториальной патологией, формирования групп риска и развития культуры питания.Целью исследования была оценка генетических аспектов дефицита лактозы среди населения и его связи с патологиями человека на примере перелома бедра.Материал и методы: Фенотип непереносимости лактозы обнаружен у 9,7 % украинцев, а стойкость лактозы – 69,4 %. В группе пациентов с переломами проксимального отдела бедра и коксартрозом все частоты составили: 13910Т – 0,34, 13910С – 0,66, 22018А – 0,35, 22018G – 0,65. Распределение генотипов составило 0 %: 67,6 %: 32,4 % для TT:CT:CC и 2,9 %: 64,7 %: 32,4 % для AA:GA:GG. Отклонения от равновесия по Харди-Вайнбергу не наблюдалось.Результаты: При анализе генотипов обоих SNP было установлено соотношение CTAA: CTGA: CCGA: CCGG – 2,9 %: 61,7 %: 2,9 %: 32,5 %. Было оценено неравновесие по сцеплению, D’(r2) для проанализированных SNP составил 0,209 (0,554). У половины пациентов был остеопороз или остеопения (n = 50,0 %), однако среди пациентов с генотипом TTAA эти заболевания не наблюдались. Показатели МПК у пациентов с CTGA составили 4049,8±38,7 и у пациентов с CCGG – 4109,6±30,0.Выводы: Все пациенты с остеопорозом имели генотип CTGA, среднее значение МПК составило 3795,6±43,8. У пациентов с генотипом CTGA наблюдались следующие патологии желудочно-кишечного тракта: гастрит (33,3 %), язвенная болезнь желудка (9,5 %), язва двенадцатиперстной кишки (9,5 %), рак желудка (9,5 %). Гетерозиготные генотипы значительно увеличивают риск желудочно-кишечной патологии у пациентов с переломами проксимального отдела бедренной кости в пять раз, Близько 75 % світового населення втрачає здатність до толерантності до лактози в зрілому віці. Вивчення толерантності до лактози (ЛТ) або персистентності лактази (ЛП) в українців є необхідним для виявлення зв’язку цієї ознаки з мультифакторіальними патологіями, формування груп ризику та розвитку харчової культури.Метою дослідження була оцінка генетичних аспектів дефіциту лактози серед населення та його зв’язок з патологіями людини на прикладі перелому стегна.Матеріал та методи: Фенотип непереносимості лактози був виявлений у 9,7 % українців, а стійкість до лактози – 69,4 %. У групі хворих з переломами проксимальної стегнової кістки лезними частотами були: 13910Т – 0,34, 13910С – 0,66, 22018G – 0,35, 22018Г – 0,65. Розподіл генотипів становив 0 %: 67,6 %: 32,4 % для TT:CT:CC та 2,9 %: 64,7 %: 32,4 %, для AA:GA:GG. Відхилення від рівноваги Харді-Вайнберга не спостерігалось.Результати: В результаті аналізу генотипів для обох SNP було встановлено співвідношення CTAA: CTGA: CCGA: CCGG – 2,9 %: 61,7 %: 2,9 %: 32,5 %. Було оцінено нерівновагу за зчепленням, D’(r2) для аналізованих SNP склав 0,209 (0,554). У половини пацієнтів був остеопороз або остеопенія (n = 50,0 %), але у пацієнтів з генотипом TTAA цих патологій не виявлено. Параметри МЩК хворих з генотипом CTGA склали 4049,8±38,7 і 4109,6±30,0 для пацієнтів з CCGG.Висновки: Усі пацієнти з остеопорозом мали генотип CTGA, середнє значення МПК становило 3795,6±43,8. У пацієнтів з генотипом CTGA спостерігались такі патології шлунково-кишкового тракту: гастрит (33,3 %), виразкова хвороба (9,5 %), виразка дванадцятипалої кишки (9,5 %), рак шлунка (9,5 %). Гетерозиготні генотипи значно збільшують ризик розвитку шлунково-кишкової патології у пацієнтів з переломами проксимальної стегнової кістки в п’ять разів

The aim of the work was to evaluate the effectiveness of a physical therapy program for athletes specializing in team sports games with diaphysis fractures of the shin after intramedullary osteosynthesis. Materials and methods. Experimental studies were conducted with athletes in game sports (n = 58) with diaphyseal fractures of the tibia, who were treated in the Department of Traumatology and Orthopedics of the Clinical Hospital № 7, Kyiv, SI “Institute of Traumatology and Orthopedics NAMS of Ukraine”, sports clinic injuries of NUFVSU during 2014–2019. Methods of analysis and generalization of literature sources were used; method of anthropometric measurements to determine the comprehensiveness of a healthy and injured limb; goniometry method for measuring the available range of motion in the knee joint of a healthy and injured limb; myotonometry method to determine the tone of the quadriceps femoris; testing to calculate the symmetry index of the lower extremities (LSI ‒ Lower Extremity Symmetry Index); methods of mathematical statistics. Results. The developed complex program of physical therapy is a cycle of restorative measures that meet the achievement of previous functionality, meets the requirements for the level of motor skills, general and special physical performance of athletes, and meets their personal ideas about the quality of life. Evaluation of the effectiveness of the physical therapy program allows us to state that in BG the normative values were reached by 25 out of 29 athletes (86.21 %), in CG ‒ 19 athletes out of 29 (65.52 %), which indicates the high efficiency of the proposed physical therapy program. Conclusions. In the process of forming physical therapy programs for patients ‒ athletes with diaphysis fractures of the tibia after intramedullary osteosynthesis, therapeutic exercises should be grouped depending on the specific objectives of rehabilitation measures and their predominant focus: to restore motor function; to restore general physical fitness; to restore special physical fitness; to restore basic motor skills and abilities; to restore special motor skills and abilities in accordance with the specifics of training and competitive activities in sports games.

The purpose of the work is to evaluate the degree of dynamic recovery of the movements of the operated limb during the second period of rehabilitation by means of physical therapy in patients who underwent hip replacement and strengthening of the capsule-ligament apparatus with a polypropylene mesh.Materials and methods. A retrospective study of case histories, radiographs, and laboratory data of 47 patients requiring restoration or strengthening of the hip capsule was performed, of which primary endoprosthesis was performed in 26 (55.3 %) patients, and revision in 21 (44.7 %). Among the studied patients, 27 patients (57.4 %) were male, 20 patients (42.6 %) – female. The average age of the patients was 57 years (from 20 to 86 years).Results. Based on the analysis of the results of the study, we note that the quality of life of patients in both groups, the overall subjective condition of the joint, the volume of movements of the operated limb, as well as the evaluation of clinical and functional outcomes of treatment on the Harris Hip Score (HHS) directly correlate with performance preoperative exercises of a therapeutic nature and adherence to the postoperative rehabilitation program of physical therapy. Such correlation is more significant at 12 months after surgery, at 24 months of observation the indexes of the operated hip joint in the two groups of patients were not significantly different: 65.3 % of the observation group and 52.2 % of the comparison group at 12 months after surgery and 91.3 % and 81.0 % after 24 months, respectively.Conclusions. The use of polypropylene mesh to strengthen the posterior capsule ligaments of the hip joint enhances the functionality of the operated limb and restores patients overall, accelerates the physical rehabilitation process after discharge from the hospital. The expediency of careful preoperative preparation of patients and active management of the postoperative period (complexes of therapeutic exercises, informing of patients) is proved., Цель работы – оценить степень динамического восстановления движений оперированной конечности в течение II периода реабилитации средствами физической терапии у пациентов, которым выполнено эндопротезирование тазобедренного сустава и укрепление капсульно-связочного аппарата полипропиленовой сеткой.Материалы и методы. Проведено ретроспективное исследование историй болезней, рентгенограмм и лабораторных данных 47 пациентов, нуждающихся в восстановлении или укреплении капсулы тазобедренного сустава. Первичное эндопротезирование выполнено у 26 (55,3 %) пациентов, ревизионное – у 21 (44,7 %). Среди пациентов 27 (57,4 %) мужчин и 20 (42,6 %) женщин. Средний возраст пациентов составил 57 лет (от 20 до 86 лет).Результаты. На основе анализа результатов исследования отмечено, что качество жизни пациентов обеих групп, общее субъективное состояние сустава, показатели объема движений оперированной конечности, а также оценка клинико-функциональных результатов лечения по шкале Harris Hip Score (HHS) прямо коррелируют с выполнением предоперационных упражнений терапевтического характера и соблюдением послеоперационной реабилитационной программы физической терапии. Такая корреляция более существенна в срок 12 месяцев после хирургического лечения, через 24 месяца наблюдения показатели состояния оперируемого тазобедренного сустава в обеих группах пациентов существенно не отличались: 65,3 % – группа наблюдения, 52,2 % – группа сравнения через 12 месяцев после операции и 91,3 % и 81,0 % через 24 месяца соответственно.Выводы. Использование полипропиленовой сетки для укрепления задних капсульно-связных структур тазобедренного сустава приводит к расширению функциональных возможностей оперируемой конечности и восстановления пациентов, ускоряет процессы физической реабилитации после выписки из стационара. Доказана целесообразность тщательной предоперационной подготовки пациентов и активного ведения послеоперационного периода (комплексы терапевтических упражнений, информирование пациентов), что позволяет улучшить результаты хирургического и восстановительного лечения, избежать возможных осложнений при условии выполнения рекомендаций и комплексного применения средств физической терапии., Мета роботи – оцінити ступінь динамічного відновлення рухів оперованої кінцівки протягом ІІ періоду реабілітації засобами фізичної терапії в пацієнтів, яким виконане ендопротезування кульшового суглоба та зміцнення капсульно-зв’язкового апарату поліпропіленовою сіткою.Матеріали та методи. Здійснили ретроспективне дослідження історій хвороб, рентгенограм і лабораторних даних 47 пацієнтів, які потребували відновлення чи зміцнення капсули кульшового суглоба. Первинне ендопротезування виконали у 26 (55,3 %) пацієнтів, ревізійне ‒ у 21 (44,7 %). Серед пацієнтів було 27 (57,4 %) чоловіків і 20 (42,6 %) жінок. Середній вік пацієнтів становив 57 років (від 20 до 86 років).Результати. На підставі аналізу результатів дослідження визначили, що якість життя пацієнтів обох груп, загальний суб’єктивний стан суглоба, показники обсягу рухів оперованої кінцівки, а також оцінка клініко-функціональних результатів лікування за шкалою Harris Hip Score (HHS) прямо корелюють із виконанням передопераційних вправ терапевтичного характеру та дотриманням післяопераційної реабілітаційної програми фізичної терапії. Така кореляція є істотнішою в термін 12 місяців після хірургічного лікування, через 24 місяці спостереження показники стану оперованого кульшового суглоба в обох групах пацієнтів суттєво не відрізнялися: 65,3 % – група спостереження, 52,2 % – група порівняння через 12 місяців після операції та 91,3 % і 81,0 % через 24 місяці відповідно.Висновки. Використання поліпропіленової сітки для зміцнення задніх капсульно-зв’язкових структур кульшового суглоба призводить до розширення функціональних можливостей оперованої кінцівки та відновлення пацієнтів, прискорює процеси фізичної реабілітації після виписування зі стаціонара. Доведено доцільність ретельної передопераційної підготовки пацієнтів та активного ведення післяопераційного періоду (комплекси терапевтичних вправ, інформування пацієнтів), що дає можливість поліпшити результати хірургічного та відновного лікування, уникнути можливих ускладнень за умови виконання рекомендацій і комплексного застосування засобів фізичної терапії.