275 results on '"Probst‐Hensch, Nicole"'
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2. Factors Associated With COVID-19 Non-Vaccination in Switzerland: A Nationwide Study
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Sabatini, Serena, Kaufmann, Marco, Fadda, Marta, Tancredi, Stefano, Noor, Nazihah, Van der Linden, Bernadette W. A., Cullati, Stéphanie, Frank, Irène, Michel, Gisela, Harju, Erika, Lüdi, Chantal, Frei, Anja, Ballouz, Tala, Menges, Dominik, Fehr, Jan, Kohler, Philipp, Kahlert, Christian R., Scheu, Victor, Ortega, Natalia, Chocano-Bedoya, Patricia, Rodondi, Nicolas, Stringhini, Silvia, Baysson, Hélène, Lorthe, Elsa, Zufferey, Maria Caiata, Suggs, L. Suzanne, Albanese, Emiliano, Vincentini, Julia, Bochud, Murielle, D'Acremont, Valérie, Nusslé, Samira Gonseth, Imboden, Medea, Keidel, Dirk, Witzig, Melissa, Probst-Hensch, Nicole, and Von Wyl, Viktor
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Health (social science) ,Attitudes and beliefs ,Adult ,Humans ,Switzerland/epidemiology ,COVID-19/epidemiology ,COVID-19/prevention & control ,COVID-19 Vaccines ,Cross-Sectional Studies ,SARS-CoV-2 ,COVID-19 ,attitudes and beliefs ,preventive measures ,vaccination acceptance ,Preventive measures ,360 Social problems & social services ,Public Health, Environmental and Occupational Health ,Vaccination acceptance ,610 Medicine & health ,614: Public Health und Gesundheitsförderung - Abstract
Objectives: We compared socio-demographic characteristics, health-related variables, vaccination-related beliefs and attitudes, vaccination acceptance, and personality traits of individuals who vaccinated against COVID-19 and who did not vaccinate by December 2021.Methods: This cross-sectional study used data of 10,642 adult participants from the Corona Immunitas eCohort, an age-stratified random sample of the population of several cantons in Switzerland. We used multivariable logistic regression models to explore associations of vaccination status with socio-demographic, health, and behavioral factors.Results: Non-vaccinated individuals represented 12.4% of the sample. Compared to vaccinated individuals, non-vaccinated individuals were more likely to be younger, healthier, employed, have lower income, not worried about their health, have previously tested positive for SARS-CoV-2 infection, express lower vaccination acceptance, and/or report higher conscientiousness. Among non-vaccinated individuals, 19.9% and 21.3% had low confidence in the safety and effectiveness of SARS-CoV-2 vaccine, respectively. However, 29.1% and 26.7% of individuals with concerns about vaccine effectiveness and side effects at baseline, respectively vaccinated during the study period.Conclusion: In addition to known socio-demographic and health-related factors, non-vaccination was associated with concerns regarding vaccine safety and effectiveness., + ID der Publikation: unilu_68453 + Sprache: Englisch + Letzte Aktualisierung: 2023-06-30 12:14:10
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- 2023
3. Association of hypertension, diabetes and cardiovascular disease with COVID-19 in Africa: scoping review protocol
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Ali, Faisal, Utzinger, Jürg, Paris, Daniel, Probst-Hensch, Nicole, and Chernet, Afona
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Infectious Diseases ,General Immunology and Microbiology ,Medicine and Health Sciences ,Public Health, Environmental and Occupational Health - Abstract
Background The unprecedented spread of COVID-19 posed devastating effects on the global health care systems. People with chronic comorbidities have been at a particularly high risk for severe COVID-19. However, evidence on association of COVID-19 severity with hypertension, diabetes and cardiovascular diseases in the African population is still scarce. Objective The aim of this scoping review is to estimate the severity of COVID-19 among African patients with hypertension, diabetes and cardiovascular diseases and its implications for case management in Africa. Methods and analysis The current scoping review will be conducted in compliance with the extension for Scoping Reviews of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA-ScR). Articles will be served on the following electronic databases: PubMed, Scopus, Web of Science, Embase, CINAHL and the JBI Database of Systematic Reviews. The search will be conducted after the publication of this protocol. Articles published after March 2020 will be considered without language restrictions. Two reviewers will extract data from relevant articles. Descriptive analysis of the important findings will be conducted and a narrative synthesis of the results will serve as the basis for interpretation. Expected results and conclusion This scoping review is expected to determine the likelihood of patients with chronic comorbidities to progress to severe stage of COVID-19. In doing so it will generate evidence and set foundations for recommendations towards the establishment of surveillance systems and referral guidelines for the management of non-communicable diseases in face of COVID-19 and future pandemics.
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- 2023
4. EU-wide exposure data of 11 chemical substance groups from the HBM4EU Aligned Studies (2014–2021)
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Govarts, Eva, Gilles, Liese, Rodriguez Martin, Laura, Santonen, Tiina, Apel, Petra, Alvito, Paula, Anastasi, Elena, Andersen, Helle Raun, Andersson, Anna Maria, Andryskova, Lenka, Antignac, Jean Philippe, Appenzeller, Brice, Barbone, Fabio, Barnett-Itzhaki, Zohar, Barouki, Robert, Berman, Tamar, Bil, Wieneke, Borges, Teresa, Buekers, Jurgen, Cañas-Portilla, Ana, Covaci, Adrian, Csako, Zsofia, Den Hond, Elly, Dvorakova, Darina, Fabelova, Lucia, Fletcher, Tony, Frederiksen, Hanne, Gabriel, Catherine, Ganzleben, Catherine, Göen, Thomas, Halldorsson, Thorhallur I., Haug, Line S., Horvat, Milena, Huuskonen, Pasi, Imboden, Medea, Jagodic Hudobivnik, Marta, Janasik, Beata, Janev Holcer, Natasa, Karakitsios, Spyros, Katsonouri, Andromachi, Klanova, Jana, Kokaraki, Venetia, Kold Jensen, Tina, Koponen, Jani, Laeremans, Michelle, Laguzzi, Federica, Lange, Rosa, Lemke, Nora, Lignell, Sanna, Lindroos, Anna Karin, Lobo Vicente, Joana, Luijten, Mirjam, Makris, Konstantinos C., Mazej, Darja, Melymuk, Lisa, Meslin, Matthieu, Mol, Hans, Montazeri, Parisa, Murawski, Aline, Namorado, Sónia, Niemann, Lars, Nübler, Stefanie, Nunes, Baltazar, Olafsdottir, Kristin, Palkovicova Murinova, Lubica, Papaioannou, Nafsika, Pedraza-Diaz, Susana, Piler, Pavel, Plichta, Veronika, Poteser, Michael, Probst-Hensch, Nicole, Rambaud, Loïc, Rauscher-Gabernig, Elke, Rausova, Katarina, Remy, Sylvie, Riou, Margaux, Rosolen, Valentina, Rousselle, Christophe, Rüther, Maria, Sarigiannis, Denis, Silva, Maria J., Šlejkovec, Zdenka, Snoj Tratnik, Janja, Stajnko, Anja, Szigeti, Tamas, Tarazona, José V., Thomsen, Cathrine, Tkalec, Žiga, Tolonen, Hanna, Trnovec, Tomas, Uhl, Maria, Van Nieuwenhuyse, An, Vasco, Elsa, Verheyen, Veerle J., Viegas, Susana, Vinggaard, Anne Marie, Vogel, Nina, Vorkamp, Katrin, Wasowicz, Wojciech, Weber, Till, Wimmerova, Sona, Woutersen, Marjolijn, Zimmermann, Philipp, Zvonar, Martin, Koch, Holger, Kolossa-Gehring, Marike, Esteban López, Marta, Castaño, Argelia, Stewart, Lorraine, Sepai, Ovnair, Schoeters, Greet, and NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
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HBM4EU ,SDG 3 - Good Health and Well-being ,Public Health, Environmental and Occupational Health ,Adults ,Exposure biomarkers ,Children ,Teenagers ,Human biomonitoring (HBM) - Abstract
Funding Information: The authors would like to thank everybody who contributed to the HBM4EU Aligned Studies: the participating children, teenagers, adults and their families, the fieldworkers that collected the samples and database managers that made the information available to HBM4EU, the HBM4EU project partners, especially those from WP7 for developing all materials supporting the fieldwork, WP9 for organizing the QA/QC scheme under HBM4EU and all laboratories who performed the analytical measurements. We would like to acknowledge Sun Kyoung Jung from the National Institute of Environmental Research of South-Korea for providing the KoNEHS Cycle III results (crt adjusted). HBM4EU is co-financed under Horizon 2020 (grant agreement No 733032). The authors thank all principal investigators of the contributing studies for their participation and contribution to the HBM4EU Aligned Studies and the national program owners for their financial support. Further details on funding for all the participating studies can be found in the Supplemental Material, Table S12. As one of the core elements of the European Human Biomonitoring Initiative (HBM4EU) a human biomonitoring (HBM) survey was conducted in 23 countries to generate EU-wide comparable HBM data. This survey has built on existing HBM capacity in Europe by aligning national or regional HBM studies, referred to as the HBM4EU Aligned Studies. The HBM4EU Aligned Studies included a total of 10,795 participants of three age groups: (i) 3,576 children aged 6–12 years, (ii) 3,117 teenagers aged 12–18 years and (iii) 4,102 young adults aged 20–39 years. The participants were recruited between 2014 and 2021 in 11–12 countries per age group, geographically distributed across Europe. Depending on the age group, internal exposure to phthalates and the substitute DINCH, halogenated and organophosphorus flame retardants, per- and polyfluoroalkyl substances (PFASs), cadmium, bisphenols, polycyclic aromatic hydrocarbons (PAHs), arsenic species, acrylamide, mycotoxins (deoxynivalenol (total DON)), benzophenones and selected pesticides was assessed by measuring substance specific biomarkers subjected to stringent quality control programs for chemical analysis. For substance groups analyzed in different age groups higher average exposure levels were observed in the youngest age group, i.e., phthalates/DINCH in children versus teenagers, acrylamide and pesticides in children versus adults, benzophenones in teenagers versus adults. Many biomarkers in teenagers and adults varied significantly according to educational attainment, with higher exposure levels of bisphenols, phthalates, benzophenones, PAHs and acrylamide in participants (from households) with lower educational attainment, while teenagers from households with higher educational attainment have higher exposure levels for PFASs and arsenic. In children, a social gradient was only observed for the non-specific pyrethroid metabolite 3-PBA and di-isodecyl phthalate (DiDP), with higher levels in children from households with higher educational attainment. Geographical variations were seen for all exposure biomarkers. For 15 biomarkers, the available health-based HBM guidance values were exceeded with highest exceedance rates for toxicologically relevant arsenic in teenagers (40%), 3-PBA in children (36%), and between 11 and 14% for total DON, Σ (PFOA + PFNA + PFHxS + PFOS), bisphenol S and cadmium. The infrastructure and harmonized approach succeeded in obtaining comparable European wide internal exposure data for a prioritized set of 11 chemical groups. These data serve as a reference for comparison at the global level, provide a baseline to compare the efficacy of the European Commission's chemical strategy for sustainability and will give leverage to national policy makers for the implementation of targeted measures. publishersversion published
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- 2023
5. Association between exposure to multiple air pollutants, transportation noise and cause-specific mortality in adults in Switzerland
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Vienneau, Danielle, Stafoggia, Massimo, Rodopoulou, Sophia, Chen, Jie, Atkinson, Richard W, Bauwelinck, Mariska, Klompmaker, Jochem O, Oftedal, Bente, Andersen, Zorana J, Janssen, Nicole A H, So, Rina, Lim, Youn-Hee, Flückiger, Benjamin, Ducret-Stich, Regina, Röösli, Martin, Probst-Hensch, Nicole, Künzli, Nino, Strak, Maciek, Samoli, Evangelia, de Hoogh, Kees, Brunekreef, Bert, and Hoek, Gerard
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Metals ,Air ,Health, Toxicology and Mutagenesis ,Respiratory ,Public Health, Environmental and Occupational Health ,Mortality ,Traffic-related pollution ,Cardiovascular ,Noise - Abstract
Background Long-term exposure to air pollution and noise is detrimental to health; but studies that evaluated both remain limited. This study explores associations with natural and cause-specific mortality for a range of air pollutants and transportation noise. Methods Over 4 million adults in Switzerland were followed from 2000 to 2014. Exposure to PM2.5, PM2.5 components (Cu, Fe, S and Zn), NO2, black carbon (BC) and ozone (O3) from European models, and transportation noise from source-specific Swiss models, were assigned at baseline home addresses. Cox proportional hazards models, adjusted for individual and area-level covariates, were used to evaluate associations with each exposure and death from natural, cardiovascular (CVD) or non-malignant respiratory disease. Analyses included single and two exposure models, and subset analysis to study lower exposure ranges. Results During follow-up, 661,534 individuals died of natural causes (36.6% CVD, 6.6% respiratory). All exposures including the PM2.5 components were associated with natural mortality, with hazard ratios (95% confidence intervals) of 1.026 (1.015, 1.038) per 5 µg/m3 PM2.5, 1.050 (1.041, 1.059) per 10 µg/m3 NO2, 1.057 (1.048, 1.067) per 0.5 × 10–5/m BC and 1.045 (1.040, 1.049) per 10 dB Lden total transportation noise. NO2, BC, Cu, Fe and noise were consistently associated with CVD and respiratory mortality, whereas PM2.5 was only associated with CVD mortality. Natural mortality associations persisted 3 for PM2.5 and NO2, –5/m BC and 3 association was inverse for all outcomes. Including noise attenuated all outcome associations, though many remained significant. Across outcomes, noise was robust to adjustment to air pollutants (e.g. natural mortality 1.037 (1.033, 1.042) per 10 dB Lden total transportation noise, after including BC). Conclusion Long-term exposure to air pollution and transportation noise in Switzerland contribute to premature mortality. Considering co-exposures revealed the importance of local traffic-related pollutants such as NO2, BC and transportation noise.
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- 2023
6. Changes in socioeconomic resources and mental health after the second COVID-19 wave (2020–2021): a longitudinal study in Switzerland
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Tancredi, Stefano, Ulytė, Agnė, Wagner, Cornelia, Keidel, Dirk, Witzig, Melissa, Imboden, Medea, Probst-Hensch, Nicole, Amati, Rebecca, Albanese, Emiliano, Levati, Sara, Crivelli, Luca, Kohler Philipp, Cusini, Alexa, Kahlert, Christian, Harju, Erika, Michel, Gisela, Lüdi, Chantal, Ortega, Natalia, Baggio, Stèphanie, Chocano-Bedoya, Patricia, Nicolas Rodondi, Ballouz, Tala, Frei, Anja, Kaufmann, Marco, Von Wyl, Viktor, Lorthe, Elsa, Baysson, Hélène, Stringhini, Silvia, Schneider, Valentine, Kaufmann, Laurent, Wieber, Frank, Volken, Thomas, Zysset, Annina, Dratva, Julia, and Cullati, Stéphane
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Employment ,SARS-CoV-2 ,Depression ,socioeconomic condition ,Depressive symptoms ,COVID-19 ,610 Medicine & health ,anxiety ,financial resources ,stress ,360 Social problems & social services ,331: Arbeitsökonomie ,Mental health ,613: Persönliche Gesundheit ,Longitudinal study ,Pandemics ,Switzerland ,Human - Abstract
During the 2020/2021 winter, the labour market was under the impact of the COVID-19 pandemic. Changes in socioeconomic resources during this period could have influenced individual mental health. This association may have been mitigated or exacerbated by subjective risk perceptions, such as perceived risk of getting infected with SARS-CoV-2 or perception of the national economic situation. Therefore, we aimed to determine if changes in financial resources and employment situation during and after the second COVID-19 wave were prospectively associated with depression, anxiety and stress, and whether perceptions of the national economic situation and of the risk of getting infected modified this association. Methods: One thousand seven hundred fifty nine participants from a nation-wide population-based eCohort in Switzerland were followed between November 2020 and September 2021. Financial resources and employment status were assessed twice (Nov2020–Mar2021, May–Jul 2021). Mental health was assessed after the second measurement of financial resources and employment status, using the Depression, Anxiety and Stress Scale (DASS-21). We modelled DASS-21 scores with linear regression, adjusting for demographics, health status, social relationships and changes in workload, and tested interactions with subjective risk perceptions. Results: We observed scores above thresholds for normal levels for 16% (95%CI = 15–18) of participants for depression, 8% (95%CI = 7–10) for anxiety, and 10% (95%CI = 9–12) for stress. Compared to continuously comfortable or sufficient financial resources, continuously precarious or insufficient resources were associated with worse scores for all outcomes. Increased financial resources were associated with higher anxiety. In the working-age group, shifting from full to part-time employment was associated with higher stress and anxiety. Perceiving the Swiss economic situation as worrisome was associated with higher anxiety in participants who lost financial resources or had continuously precarious or insufficient resources. Conclusion: This study confirms the association of economic stressors and mental health during the COVID-19 pandemic and highlights the exacerbating role of subjective risk perception on this association., + ID der Publikation: unilu_68003 + Sprache: Englisch + Letzte Aktualisierung: 2023-03-24 09:56:56
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- 2023
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7. Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
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Shrine, Nick, Izquierdo, Abril G, Chen, Jing, Packer, Richard, Hall, Robert J, Guyatt, Anna L, Batini, Chiara, Thompson, Rebecca J, Pavuluri, Chandan, Malik, Vidhi, Hobbs, Brian D, Moll, Matthew, Kim, Wonji, Tal-Singer, Ruth, Bakke, Per, Fawcett, Katherine A, John, Catherine, Coley, Kayesha, Piga, Noemi Nicole, Pozarickij, Alfred, Lin, Kuang, Millwood, Iona Y, Chen, Zhengming, Li, Liming, China Kadoorie Biobank Collaborative Group, Wijnant, Sara RA, Lahousse, Lies, Brusselle, Guy, Uitterlinden, Andre G, Manichaikul, Ani, Oelsner, Elizabeth C, Rich, Stephen S, Barr, R Graham, Kerr, Shona M, Vitart, Veronique, Brown, Michael R, Wielscher, Matthias, Imboden, Medea, Jeong, Ayoung, Bartz, Traci M, Gharib, Sina A, Flexeder, Claudia, Karrasch, Stefan, Gieger, Christian, Peters, Annette, Stubbe, Beate, Hu, Xiaowei, Ortega, Victor E, Meyers, Deborah A, Bleecker, Eugene R, Gabriel, Stacey B, Gupta, Namrata, Smith, Albert Vernon, Luan, Jian'an, Zhao, Jing-Hua, Hansen, Ailin F, Langhammer, Arnulf, Willer, Cristen, Bhatta, Laxmi, Porteous, David, Smith, Blair H, Campbell, Archie, Sofer, Tamar, Lee, Jiwon, Daviglus, Martha L, Yu, Bing, Lim, Elise, Xu, Hanfei, O'Connor, George T, Thareja, Gaurav, Albagha, Omar ME, Qatar Genome Program Research (QGPR) Consortium, Suhre, Karsten, Granell, Raquel, Faquih, Tariq O, Hiemstra, Pieter S, Slats, Annelies M, Mullin, Benjamin H, Hui, Jennie, James, Alan, Beilby, John, Patasova, Karina, Hysi, Pirro, Koskela, Jukka T, Wyss, Annah B, Jin, Jianping, Sikdar, Sinjini, Lee, Mikyeong, May-Wilson, Sebastian, Pirastu, Nicola, Kentistou, Katherine A, Joshi, Peter K, Timmers, Paul RHJ, Williams, Alexander T, Free, Robert C, Wang, Xueyang, Morrison, John L, Gilliland, Frank D, Chen, Zhanghua, Wang, Carol A, Foong, Rachel E, Harris, Sarah E, Taylor, Adele, Redmond, Paul, Cook, James P, Mahajan, Anubha, Lind, Lars, Palviainen, Teemu, Lehtimäki, Terho, Raitakari, Olli T, Kaprio, Jaakko, Rantanen, Taina, Pietiläinen, Kirsi H, Cox, Simon R, Pennell, Craig E, Hall, Graham L, Gauderman, W James, Brightling, Chris, Wilson, James F, Vasankari, Tuula, Laitinen, Tarja, Salomaa, Veikko, Mook-Kanamori, Dennis O, Timpson, Nicholas J, Zeggini, Eleftheria, Dupuis, Josée, Hayward, Caroline, Brumpton, Ben, Langenberg, Claudia, Weiss, Stefan, Homuth, Georg, Schmidt, Carsten Oliver, Probst-Hensch, Nicole, Jarvelin, Marjo-Riitta, Morrison, Alanna C, Polasek, Ozren, Rudan, Igor, Lee, Joo-Hyeon, Sayers, Ian, Rawlins, Emma L, Dudbridge, Frank, Silverman, Edwin K, Strachan, David P, Walters, Robin G, Morris, Andrew P, London, Stephanie J, Cho, Michael H, Wain, Louise V, Hall, Ian P, Tobin, Martin D, Shrine, Nick [0000-0003-3641-4371], Chen, Jing [0000-0003-1287-1930], Guyatt, Anna L. [0000-0003-1860-6337], Hobbs, Brian D. [0000-0001-9564-0745], Kim, Wonji [0000-0002-1249-797X], Coley, Kayesha [0000-0003-4951-6799], Chen, Zhengming [0000-0001-6423-105X], Li, Liming [0000-0001-5873-7089], Lahousse, Lies [0000-0002-3494-4363], Uitterlinden, Andre G. [0000-0002-7276-3387], Oelsner, Elizabeth C. [0000-0002-7481-9671], Rich, Stephen S. [0000-0003-3872-7793], Kerr, Shona M. [0000-0002-4137-1495], Vitart, Veronique [0000-0002-4991-3797], Jeong, Ayoung [0000-0003-1542-0756], Gharib, Sina A. [0000-0002-2480-4367], Gieger, Christian [0000-0001-6986-9554], Peters, Annette [0000-0001-6645-0985], Hu, Xiaowei [0000-0001-7804-7392], Smith, Albert Vernon [0000-0003-1942-5845], Luan, Jian’an [0000-0003-3137-6337], Langhammer, Arnulf [0000-0001-5296-6673], Willer, Cristen [0000-0001-5645-4966], Porteous, David [0000-0003-1249-6106], Smith, Blair H. [0000-0002-5362-9430], Campbell, Archie [0000-0003-0198-5078], Sofer, Tamar [0000-0001-8520-8860], Lee, Jiwon [0000-0002-4079-7494], Lim, Elise [0000-0001-8967-8464], Thareja, Gaurav [0000-0003-2277-6400], Albagha, Omar M. E. [0000-0001-5916-5983], Suhre, Karsten [0000-0001-9638-3912], Granell, Raquel [0000-0002-4890-4012], Faquih, Tariq O. [0000-0001-8026-2251], Hiemstra, Pieter S. [0000-0002-0238-5982], Hysi, Pirro [0000-0001-5752-2510], Koskela, Jukka T. [0000-0002-0154-7222], Jin, Jianping [0000-0002-3774-1609], Sikdar, Sinjini [0000-0003-1230-5162], Lee, Mikyeong [0000-0002-3036-3684], May-Wilson, Sebastian [0000-0003-2668-5717], Joshi, Peter K. [0000-0002-6361-5059], Timmers, Paul R. H. J. [0000-0002-5197-1267], Gilliland, Frank D. [0000-0002-9033-7269], Wang, Carol A. [0000-0002-4301-3974], Harris, Sarah E. [0000-0002-4941-5106], Mahajan, Anubha [0000-0001-5585-3420], Palviainen, Teemu [0000-0002-7847-8384], Kaprio, Jaakko [0000-0002-3716-2455], Pietiläinen, Kirsi H. [0000-0002-8522-1288], Cox, Simon R. [0000-0003-4036-3642], Pennell, Craig E. [0000-0002-0937-6165], Wilson, James F. [0000-0001-5751-9178], Vasankari, Tuula [0000-0002-1413-8970], Salomaa, Veikko [0000-0001-7563-5324], Timpson, Nicholas J. [0000-0002-7141-9189], Dupuis, Josée [0000-0003-2871-3603], Brumpton, Ben [0000-0002-3058-1059], Langenberg, Claudia [0000-0002-5017-7344], Weiss, Stefan [0000-0002-3553-4315], Homuth, Georg [0000-0001-6839-0605], Jarvelin, Marjo-Riitta [0000-0002-2149-0630], Morrison, Alanna C. [0000-0001-6381-4296], Rudan, Igor [0000-0001-6993-6884], Lee, Joo-Hyeon [0000-0002-7364-6422], Sayers, Ian [0000-0001-5601-5410], Rawlins, Emma L. [0000-0001-7426-3792], Dudbridge, Frank [0000-0002-8817-8908], Strachan, David P. [0000-0001-7854-1366], Walters, Robin G. [0000-0002-9179-0321], Morris, Andrew P. [0000-0002-6805-6014], London, Stephanie J. [0000-0003-4911-5290], Cho, Michael H. [0000-0002-4907-1657], Wain, Louise V. [0000-0003-4951-1867], Hall, Ian P. [0000-0001-9933-3216], Tobin, Martin D. [0000-0002-3596-7874], Apollo - University of Cambridge Repository, Tampere University, Department of Clinical Chemistry, Clinical Medicine, Department of General Administration, Guyatt, Anna L [0000-0003-1860-6337], Hobbs, Brian D [0000-0001-9564-0745], Uitterlinden, Andre G [0000-0002-7276-3387], Oelsner, Elizabeth C [0000-0002-7481-9671], Rich, Stephen S [0000-0003-3872-7793], Kerr, Shona M [0000-0002-4137-1495], Gharib, Sina A [0000-0002-2480-4367], Luan, Jian'an [0000-0003-3137-6337], Smith, Blair H [0000-0002-5362-9430], Albagha, Omar ME [0000-0001-5916-5983], Faquih, Tariq O [0000-0001-8026-2251], Hiemstra, Pieter S [0000-0002-0238-5982], Koskela, Jukka T [0000-0002-0154-7222], Joshi, Peter K [0000-0002-6361-5059], Timmers, Paul RHJ [0000-0002-5197-1267], Gilliland, Frank D [0000-0002-9033-7269], Wang, Carol A [0000-0002-4301-3974], Harris, Sarah E [0000-0002-4941-5106], Pietiläinen, Kirsi H [0000-0002-8522-1288], Cox, Simon R [0000-0003-4036-3642], Pennell, Craig E [0000-0002-0937-6165], Wilson, James F [0000-0001-5751-9178], Timpson, Nicholas J [0000-0002-7141-9189], Morrison, Alanna C [0000-0001-6381-4296], Rawlins, Emma L [0000-0001-7426-3792], Strachan, David P [0000-0001-7854-1366], Walters, Robin G [0000-0002-9179-0321], Morris, Andrew P [0000-0002-6805-6014], London, Stephanie J [0000-0003-4911-5290], Cho, Michael H [0000-0002-4907-1657], Wain, Louise V [0000-0003-4951-1867], Hall, Ian P [0000-0001-9933-3216], Tobin, Martin D [0000-0002-3596-7874], Epidemiology, and Internal Medicine
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Smoking ,631/208/205/2138 ,45/43 ,article ,692/699/1785 ,Polymorphism, Single Nucleotide ,3142 Public health care science, environmental and occupational health ,Pulmonary Disease, Chronic Obstructive ,Genetics ,Humans ,1182 Biochemistry, cell and molecular biology ,Genetic Predisposition to Disease ,Lung ,Genome-Wide Association Study - Abstract
Funder: British Lung Foundation, Funder: National Institute for Health Research (NIHR), Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups. We undertook phenome-wide association studies for selected associated variants as well as trait and pathway-specific genetic risk scores to infer possible consequences of intervening in pathways underlying lung function. We highlight new putative causal variants, genes, proteins and pathways, including those targeted by existing drugs. These findings bring us closer to understanding the mechanisms underlying lung function and COPD, and should inform functional genomics experiments and potentially future COPD therapies.
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- 2023
8. Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
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Shrine, Nick, Izquierdo, Abril G, Chen, Jing, Packer, Richard, Hall, Robert J, Guyatt, Anna L, Batini, Chiara, Thompson, Rebecca J, Pavuluri, Chandan, Malik, Vidhi, Hobbs, Brian D, Moll, Matthew, Kim, Wonji, Tal-Singer, Ruth, Bakke, Per, Fawcett, Katherine A, John, Catherine, Coley, Kayesha, Piga, Noemi Nicole, Pozarickij, Alfred, Lin, Kuang, Millwood, Iona Y, Chen, Zhengming, Li, Liming, Wijnant, Sara RA, Lahousse, Lies, Brusselle, Guy, Uitterlinden, Andre G, Manichaikul, Ani, Oelsner, Elizabeth C, Rich, Stephen S, Barr, R Graham, Kerr, Shona M, Vitart, Veronique, Brown, Michael R, Wielscher, Matthias, Imboden, Medea, Jeong, Ayoung, Bartz, Traci M, Gharib, Sina A, Flexeder, Claudia, Karrasch, Stefan, Gieger, Christian, Peters, Annette, Stubbe, Beate, Hu, Xiaowei, Ortega, Victor E, Meyers, Deborah A, Bleecker, Eugene R, Gabriel, Stacey B, Gupta, Namrata, Smith, Albert Vernon, Luan, Jian’an, Zhao, Jing-Hua, Hansen, Ailin F, Langhammer, Arnulf, Willer, Cristen, Bhatta, Laxmi, Porteous, David, Smith, Blair H, Campbell, Archie, Sofer, Tamar, Lee, Jiwon, Daviglus, Martha L, Yu, Bing, Lim, Elise, Xu, Hanfei, O’Connor, George T, Thareja, Gaurav, Albagha, Omar ME, Ismail, Said I, Al-Muftah, Wadha, Badji, Radja, Mbarek, Hamdi, Darwish, Dima, Fadl, Tasnim, Yasin, Heba, Ennaifar, Maryem, Abdellatif, Rania, Alkuwari, Fatima, Alvi, Muhammad, Al-Sarraj, Yasser, Saad, Chadi, Althani, Asmaa, Fethnou, Eleni, Qafoud, Fatima, Alkhayat, Eiman, Afifi, Nahla, Tomei, Sara, Liu, Wei, Lorenz, Stephan, Syed, Najeeb, Almabrazi, Hakeem, Vempalli, Fazulur Rehaman, Temanni, Ramzi, Saqri, Tariq Abu, Khatib, Mohammedhusen, Hamza, Mehshad, Zaid, Tariq Abu, El Khouly, Ahmed, Pathare, Tushar, Poolat, Shafeeq, Al-Ali, Rashid, Al-Khodor, Souhaila, Alshafai, Mashael, Badii, Ramin, Chouchane, Lotfi, Estivill, Xavier, Fakhro, Khalid, Mokrab, Younes, Puthen, Jithesh V, Tatari, Zohreh, Suhre, Karsten, Granell, Raquel, Faquih, Tariq O, Hiemstra, Pieter S, Slats, Annelies M, Mullin, Benjamin H, Hui, Jennie, James, Alan, Beilby, John, Patasova, Karina, Hysi, Pirro, Koskela, Jukka T, Wyss, Annah B, Jin, Jianping, Sikdar, Sinjini, Lee, Mikyeong, May-Wilson, Sebastian, Pirastu, Nicola, Kentistou, Katherine A, Joshi, Peter K, Timmers, Paul RHJ, Williams, Alexander T, Free, Robert C, Wang, Xueyang, Morrison, John L, Gilliland, Frank D, Chen, Zhanghua, Wang, Carol A, Foong, Rachel E, Harris, Sarah E, Taylor, Adele, Redmond, Paul, Cook, James P, Mahajan, Anubha, Lind, Lars, Palviainen, Teemu, Lehtimäki, Terho, Raitakari, Olli T, Kaprio, Jaakko, Rantanen, Taina, Pietiläinen, Kirsi H, Cox, Simon R, Pennell, Craig E, Hall, Graham L, Gauderman, W James, Brightling, Chris, Wilson, James F, Vasankari, Tuula, Laitinen, Tarja, Salomaa, Veikko, Mook-Kanamori, Dennis O, Timpson, Nicholas J, Zeggini, Eleftheria, Dupuis, Josée, Hayward, Caroline, Brumpton, Ben, Langenberg, Claudia, Weiss, Stefan, Homuth, Georg, Schmidt, Carsten Oliver, Probst-Hensch, Nicole, Jarvelin, Marjo-Riitta, Morrison, Alanna C, Polasek, Ozren, Rudan, Igor, Lee, Joo-Hyeon, Sayers, Ian, Rawlins, Emma L, Dudbridge, Frank, Silverman, Edwin K, Strachan, David P, Walters, Robin G, Morris, Andrew P, London, Stephanie J, Cho, Michael H, Wain, Louise V, Hall, Ian P, Tobin, Martin D, Shrine, Nick [0000-0003-3641-4371], Chen, Jing [0000-0003-1287-1930], Guyatt, Anna L [0000-0003-1860-6337], Hobbs, Brian D [0000-0001-9564-0745], Kim, Wonji [0000-0002-1249-797X], Coley, Kayesha [0000-0003-4951-6799], Chen, Zhengming [0000-0001-6423-105X], Li, Liming [0000-0001-5873-7089], Lahousse, Lies [0000-0002-3494-4363], Uitterlinden, Andre G [0000-0002-7276-3387], Oelsner, Elizabeth C [0000-0002-7481-9671], Rich, Stephen S [0000-0003-3872-7793], Kerr, Shona M [0000-0002-4137-1495], Vitart, Veronique [0000-0002-4991-3797], Jeong, Ayoung [0000-0003-1542-0756], Gharib, Sina A [0000-0002-2480-4367], Gieger, Christian [0000-0001-6986-9554], Peters, Annette [0000-0001-6645-0985], Hu, Xiaowei [0000-0001-7804-7392], Smith, Albert Vernon [0000-0003-1942-5845], Luan, Jian’an [0000-0003-3137-6337], Langhammer, Arnulf [0000-0001-5296-6673], Willer, Cristen [0000-0001-5645-4966], Porteous, David [0000-0003-1249-6106], Smith, Blair H [0000-0002-5362-9430], Campbell, Archie [0000-0003-0198-5078], Sofer, Tamar [0000-0001-8520-8860], Lee, Jiwon [0000-0002-4079-7494], Lim, Elise [0000-0001-8967-8464], Thareja, Gaurav [0000-0003-2277-6400], Albagha, Omar ME [0000-0001-5916-5983], Suhre, Karsten [0000-0001-9638-3912], Granell, Raquel [0000-0002-4890-4012], Faquih, Tariq O [0000-0001-8026-2251], Hiemstra, Pieter S [0000-0002-0238-5982], Hysi, Pirro [0000-0001-5752-2510], Koskela, Jukka T [0000-0002-0154-7222], Jin, Jianping [0000-0002-3774-1609], Sikdar, Sinjini [0000-0003-1230-5162], Lee, Mikyeong [0000-0002-3036-3684], May-Wilson, Sebastian [0000-0003-2668-5717], Joshi, Peter K [0000-0002-6361-5059], Timmers, Paul RHJ [0000-0002-5197-1267], Gilliland, Frank D [0000-0002-9033-7269], Wang, Carol A [0000-0002-4301-3974], Harris, Sarah E [0000-0002-4941-5106], Mahajan, Anubha [0000-0001-5585-3420], Palviainen, Teemu [0000-0002-7847-8384], Kaprio, Jaakko [0000-0002-3716-2455], Pietiläinen, Kirsi H [0000-0002-8522-1288], Cox, Simon R [0000-0003-4036-3642], Pennell, Craig E [0000-0002-0937-6165], Wilson, James F [0000-0001-5751-9178], Vasankari, Tuula [0000-0002-1413-8970], Salomaa, Veikko [0000-0001-7563-5324], Timpson, Nicholas J [0000-0002-7141-9189], Dupuis, Josée [0000-0003-2871-3603], Brumpton, Ben [0000-0002-3058-1059], Langenberg, Claudia [0000-0002-5017-7344], Weiss, Stefan [0000-0002-3553-4315], Homuth, Georg [0000-0001-6839-0605], Jarvelin, Marjo-Riitta [0000-0002-2149-0630], Morrison, Alanna C [0000-0001-6381-4296], Rudan, Igor [0000-0001-6993-6884], Lee, Joo-Hyeon [0000-0002-7364-6422], Sayers, Ian [0000-0001-5601-5410], Rawlins, Emma L [0000-0001-7426-3792], Dudbridge, Frank [0000-0002-8817-8908], Strachan, David P [0000-0001-7854-1366], Walters, Robin G [0000-0002-9179-0321], Morris, Andrew P [0000-0002-6805-6014], London, Stephanie J [0000-0003-4911-5290], Cho, Michael H [0000-0002-4907-1657], Wain, Louise V [0000-0003-4951-1867], Hall, Ian P [0000-0001-9933-3216], Tobin, Martin D [0000-0002-3596-7874], and Apollo - University of Cambridge Repository
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hengityselimet ,genome-wide association studies ,perimä ,631/208/205/2138 ,45/43 ,article ,keuhkosairaudet ,hengityselinten taudit ,riskitekijät ,692/699/1785 ,keuhkot ,perinnöllisyys ,respiratory tract diseases - Abstract
Funder: British Lung Foundation (BLF); doi: https://doi.org/10.13039/501100000351, Funder: DH | National Institute for Health Research (NIHR); doi: https://doi.org/10.13039/501100000272, Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups. We undertook phenome-wide association studies for selected associated variants as well as trait and pathway-specific genetic risk scores to infer possible consequences of intervening in pathways underlying lung function. We highlight new putative causal variants, genes, proteins and pathways, including those targeted by existing drugs. These findings bring us closer to understanding the mechanisms underlying lung function and COPD, and should inform functional genomics experiments and potentially future COPD therapies.
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- 2023
9. Residential greenspace and lung function decline over 20 years in a prospective cohort: The ECRHS study
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Markevych, Iana, Zhao, Tianyu, Fuertes, Elaine, Marcon, Alessandro, Dadvand, Payam, Vienneau, Danielle, Garcia Aymerich, Judith, Nowak, Dennis, de Hoogh, Kees, Jarvis, Deborah, Abramson, Michael J, Accordini, Simone, Amaral, Andre Fs, Bentouhami, Hayat, Jacobsen Bertelsen, Randi, Boudier, Anne, Bono, Roberto, Bowatte, Gayan, Casas, Lidia, Dharmage, Shyamali C, Forsberg, Bertil, Gislason, Thorarinn, Gnesi, Marco, Holm, Mathias, Jacquemin, Benedicte, Janson, Christer, Jogi, Rain, Johannessen, Ane, Keidel, Dirk, Leynaert, Benedicte, Maldonado Perez, José Antonio, Marchetti, Pierpaolo, Migliore, Enrica, Martínez-Moratalla, Jesús, Orru, Hans, Pin, Isabelle, Potts, James, Probst-Hensch, Nicole, Ranzi, Andrea, Sánchez-Ramos, José Luis, Siroux, Valerie, Soussan, David, Sunyer, Jordi, Urrutia Landa, Isabel, Villani, Simona, Heinrich, Joachim, Helmholtz Zentrum München (HMGU), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Ludwig-Maximilians-Universität München (LMU), German Center for Lung Research, Imperial College London, Università degli studi di Verona = University of Verona (UNIVR), Universitat Pompeu Fabra [Barcelona] (UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), University of Basel (Unibas), Swiss Tropical and Public Health Institute [Basel], Monash University [Melbourne], University of Antwerp (UA), University of Bergen (UiB), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), University of Melbourne, University of Peradeniya, Umeå University, University of Iceland [Reykjavik], University of Gothenburg (GU), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Uppsala University, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Complejo Hospitalario Universitario de Albacete, University of Tartu, CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-CHU Grenoble, Population Health and Occupational Disease [Londres, Royaume-Uni], National Heart and Lung Institute [Londres, Royaume-Uni] (NHLI), Imperial College London-Imperial College London, LabEx Inflamex, University-Hospital Munich-Großhadern [München], and This study was specifically funded by the German Research Foundation (GZ: KA 4737/2–1 | NO 262/13–1 | HE 3294/12–1) and the Comprehensive Pneumology Center Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany.The authors appreciate the support provided by the National Natural Science Foundation of China (M-0420).The present analyses are part of the Ageing Lungs in European Cohorts (ALEC) Study (https://www.alecstudy.org), which has also received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No. 633212. The local investigators and funding agencies for the European Community Respiratory Health are reported in the Supplementary Material. ISGlobal is a member of CERCA Programme/Generalitat de Catalunya. These sources of funding had no role in the study design, the collection, analysis and interpretation of data, the writing of the report, and in the decision to submit the article for publication.Iana Markevych is supported from the 'NeuroSmog: Determining the impact of air pollution on the developing brain' (Nr. POIR.04.04.00–1763/18–00) which is implemented as part of the TEAM-NET programme of the Foundation for Polish Science, co-financed from EU resources, obtained from the European Regional Development Fund under the Smart Growth Operational Programme.Elaine Fuertes is support by the Imperial College Research Fellowship.We acknowledge support from the Spanish Ministry of Science and Innovation through the 'Centro de Excelencia Severo Ochoa 2019–2023' Program (CEX2018-000806-S), and support from the Generalitat de Catalunya through the CERCA Program to ISGlobal.
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Green space ,spirometry ,nature ,ECRHS ,FEV(1) ,FVC ,Nature ,FEV1 ,Spirometry ,green space ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Human medicine ,Green space Nature Spirometry FEV 1 FVC ECRHS - Abstract
Background: The few studies that have examined associations between greenspace and lung function in adulthood have yielded conflicting results and none have examined whether the rate of lung function decline is affected. Objective: We explored the association between residential greenspace and change in lung function over 20 years in 5559 adults from 22 centers in 11 countries participating in the population-based, international European Community Respiratory Health Survey. Methods: Forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were measured by spirometry when participants were approximately 35 (1990-1994), 44 (1999-2003), and 55 (2010-2014) years old. Greenness was assessed as the mean Normalized Difference Vegetation Index (NDVI) in 500 m, 300 m, and 100 m circular buffers around the residential addresses at the time of lung function measurement. Green spaces were defined as the presence of agricultural, natural, or urban green spaces in a circular 300 m buffer. Associations of these greenspace parameters with the rate of lung function change were assessed using adjusted linear mixed effects regression models with random intercepts for subjects nested within centers. Sensitivity analyses considered air pollution exposures. Results: A 0.2-increase (average interquartile range) in NDVI in the 500 m buffer was consistently associated with a faster decline in FVC (-1.25 mL/year [95% confidence interval: -2.18 to -0.33]). These associations were especially pronounced in females and those living in areas with low PM10 levels. We found no consistent associations with FEV1 and the FEV1/FVC ratio. Residing near forests or urban green spaces was associated with a faster decline in FEV1, while agricultural land and forests were related to a greater decline in FVC. Conclusions: More residential greenspace was not associated with better lung function in middle-aged European adults. Instead, we observed slight but consistent declines in lung function parameters. The potentially detrimental association requires verification in future studies.
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- 2023
10. Barriers to evidence use for sustainability: Insights from pesticide policy and practice
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Hofmann, Benjamin, Ingold, Karin, Stamm, Christian, Ammann, Priska, Eggen, Rik I L, Finger, Robert, Fuhrimann, Samuel, Lienert, Judit, Mark, Jennifer, McCallum, Chloe, Probst-Hensch, Nicole, Reber, Ueli, Tamm, Lucius, Wiget, Milena, Winkler, Mirko S, Zachmann, Lucca, and Hoffmann, Sabine
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320 Politikwissenschaft ,Ecology ,330 Wirtschaft ,Geography, Planning and Development ,Crop health, quality, protection ,Agriculture ,General Medicine ,330 Economics ,Transformation ,Policy and practice ,Sustainability ,320 Political science ,Environmental Chemistry ,Pesticides ,Evidence - Abstract
Calls for supporting sustainability through more and better research rest on an incomplete understanding of scientific evidence use. We argue that a variety of barriers to a transformative impact of evidence arises from diverse actor motivations within different stages of evidence use. We abductively specify this variety in policy and practice arenas for three actor motivations (truth-seeking, sense-making, and utility-maximizing) and five stages (evidence production, uptake, influence on decisions, effects on sustainability outcomes, and feedback from outcome evaluations). Our interdisciplinary synthesis focuses on the sustainability challenge of reducing environmental and human health risks of agricultural pesticides. It identifies barriers resulting from (1) truth-seekers’ desire to reduce uncertainty that is complicated by evidence gaps, (2) sense-makers’ evidence needs that differ from the type of evidence available, and (3) utility-maximizers’ interests that guide strategic evidence use. We outline context-specific research–policy–practice measures to increase evidence use for sustainable transformation in pesticides and beyond., Ambio, 52 (2), ISSN:0044-7447, ISSN:1654-7209
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- 2023
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11. Global distributions of age- and sex-related arterial stiffness : systematic review and meta-analysis of 167 studies with 509,743 participants
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Lu, Yao, Kiechl, Sophia J., Wang, Jie, Xu, Qingbo, Kiechl, Stefan, Pechlaner, Raimund, Aguilar, David, Al-Hashmi, Khamis M., Alvim, Rafael O., Al-Zakwani, Ibrahim S., Antza, Christina, Cicero, Arrigo F.G., Avramovska, Maja, Avramovski, Petar, Baek, Hyun Jae, Bäck, Magnus, Bailey, Kent, Baldo, Marcelo P., Batista, Rosângela F.L., Benetos, Athanasios, Benjamin, Emelia J., Bia, Daniel, Borghi, Claudio, Roux, Shani Botha-Le, Breet, Yolandi, Burgner, David, Cardoso, Viviane C., Cecelja, Marina, Ceponiene, Indre, Chen, Chen-Huan, Cheung, Michael, Cheng, Hao-min, Cho, Jaegeol, Chowienczyk, Phil, Coelho, Eduardo B., Cseprekal, Orsolya, Silva, Amilcar BT Da, Dallaire, Frédéric, Cunha, Roberto De Sá, Diaz, Alejandro, Ferreira, Albano V.L., Ferrières, Jean, Furuta, Yoshihiko, Gómez-Marcos, Manuel A., Gómez-Sánchez, Leticia, Halcox, Julian, Hanis, Craig, Herzig, Karl-Heinz, Jaeggi, Edgar, Kavousi, Maryam, Kiechl-Kohlendorfer, Ursula, Kim, Hack-Lyoung, Kim, Mi-Kyung, Kim, Yu-Mi, Kis, Eva, Knoflach, Michael, Kotsis, Vasilios, Koyama, Teruhide, Kozakova, Michaela, Kruger, Ruan, Kullo, Iftikhar J., Kweon, Sun-Seog, Lambrinoudaki, Irene, Liu, Chang, Loeffler, Markus, Logan, Jeongok G., Maddock, Jane, Magalhães, Pedro, Maldonado, João, Mattace-Raso, Francesco U.S., Messner, Alex, Meyer, Michelle L., Mi, Jie, Mill, José Geraldo, Mitchell, Gary F., Mu, Jian-Jun, Muhammad, Iram F., Nairz, Johannes, Nakagomi, Atsushi, Nakamura, Mieko, Nilson, Peter M., Ninomiya, Toshiharu, Palombo, Carlo, Pereira, Alexandre C., Pereira, Telmo, Capingana, Daniel P., Poon, Anna K., Probst-Hensch, Nicole, Quyyumi, Arshed A., Reusz, George S., Rhee, Moo-Yong, Ribeiro, Cecilia C.C., Rietzschel, Ernst, Rocha, Paulo R.H., Rodilla, Enrique, Rojek, Marta, Ruidavets, Jean-Bernard, Rutten, Joost H.W., Saijo, Yasuaki, Salvi, Paolo, Schmidt-Trucksäss, Arno, Scholz, Markus, Shin, Min-Ho, Segers, Patrick, Stamatelopoulos, Kimon, Strazhesko, Irina D., Sugiura, Minoru, Tkacheva, Olga N., Tomiyama, Hirofumi, Urbina, Elaine M., van den Munckhof, Inge C.L., Vasan, Ramachandran S., Wake, Melissa A., Wannamethee, Goya, Wong, Andrew, Yamashina, Akira, Yan, Yinkun, Zaniqueli, Divanei, Zhu, Fang, Zócalo, Yanina, and Global Pulse Wave Velocity Study Group, on behalf of the
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Technology and Engineering ,Medicine and Health Sciences ,General Medicine ,General Biochemistry, Genetics and Molecular Biology - Abstract
Background: Arterial stiffening is central to the vascular ageing process and a powerful predictor and cause of diverse vascular pathologies and mortality. We investigated age and sex trajectories, regional differences, and global reference values of arterial stiffness as assessed by pulse wave velocity (PWV). Methods: Measurements of brachial-ankle or carotid-femoral PWV (baPWV or cfPWV) in generally healthy participants published in three electronic databases between database inception and August 24th, 2020 were included, either as individual participant-level or summary data received from collaborators (n = 248,196) or by extraction from published reports (n = 274,629). Quality was appraised using the Joanna Briggs Instrument. Variation in PWV was estimated using mixed-effects meta-regression and Generalized Additive Models for Location, Scale, and Shape. Findings: The search yielded 8920 studies, and 167 studies with 509,743 participants from 34 countries were included. PWV depended on age, sex, and country. Global age-standardised means were 12.5 m/s (95% confidence interval: 12.1–12.8 m/s) for baPWV and 7.45 m/s (95% CI: 7.11–7.79 m/s) for cfPWV. Males had higher global levels than females of 0.77 m/s for baPWV (95% CI: 0.75–0.78 m/s) and 0.35 m/s for cfPWV (95% CI: 0.33–0.37 m/s), but sex differences in baPWV diminished with advancing age. Compared to Europe, baPWV was substantially higher in the Asian region (+1.83 m/s, P = 0.0014), whereas cfPWV was higher in the African region (+0.41 m/s, P < 0.0001) and differed more by country (highest in Poland, Russia, Iceland, France, and China; lowest in Spain, Belgium, Canada, Finland, and Argentina). High vs. other country income was associated with lower baPWV (−0.55 m/s, P = 0.048) and cfPWV (−0.41 m/s, P < 0.0001).Interpretation: China and other Asian countries featured high PWV, which by known associations with central blood pressure and pulse pressure may partly explain higher Asian risk for intracerebral haemorrhage and small vessel stroke. Reference values provided may facilitate use of PWV as a marker of vascular ageing, for prediction of vascular risk and death, and for designing future therapeutic interventions. Funding: This study was supported by the excellence initiative VASCage funded by the Austrian Research Promotion Agency, by the National Science Foundation of China, and the Science and Technology Planning Project of Hunan Province. Detailed funding information is provided as part of the Acknowledgments after the main text.
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12. Additional file 1 of Changes in socioeconomic resources and mental health after the second COVID-19 wave (2020–2021): a longitudinal study in Switzerland
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Tancredi, Stefano, Ulytė, Agnė, Wagner, Cornelia, Keidel, Dirk, Witzig, Melissa, Imboden, Medea, Probst-Hensch, Nicole, Amati, Rebecca, Albanese, Emiliano, Levati, Sara, Crivelli, Luca, Kohler, Philipp, Cusini, Alexia, Kahlert, Christian, Harju, Erika, Michel, Gisela, Lüdi, Chantal, Ortega, Natalia, Baggio, Stéphanie, Chocano-Bedoya, Patricia, Rodondi, Nicolas, Ballouz, Tala, Frei, Anja, Kaufmann, Marco, Von Wyl, Viktor, Lorthe, Elsa, Baysson, Hélène, Stringhini, Silvia, Schneider, Valentine, Kaufmann, Laurent, Wieber, Frank, Volken, Thomas, Zysset, Annina, Dratva, Julia, and Cullati, Stéphane
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Additional file 1. Supplementary figures and tables
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- 2023
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13. Additional file 1 of Prevalence of fever of unidentified aetiology in East African adolescents and adults: a systematic review and meta-analysis
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Nooh, Faisal, Chernet, Afona, Reither, Klaus, Okuma, James, Brattig, Norbert W., Utzinger, Jürg, Probst-Hensch, Nicole, Paris, Daniel H., and Dreyfus, Anou
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Additional file 1: Table S1. Summary of quality assessment of included studies by the Joanna Briggs Institute critical appraisal tool assessment.
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- 2023
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14. Additional file 1 of Association between exposure to multiple air pollutants, transportation noise and cause-specific mortality in adults in Switzerland
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Vienneau, Danielle, Stafoggia, Massimo, Rodopoulou, Sophia, Chen, Jie, Atkinson, Richard W., Bauwelinck, Mariska, Klompmaker, Jochem O., Oftedal, Bente, Andersen, Zorana J., Janssen, Nicole A. H., So, Rina, Lim, Youn-Hee, Flückiger, Benjamin, Ducret-Stich, Regina, Röösli, Martin, Probst-Hensch, Nicole, Künzli, Nino, Strak, Maciek, Samoli, Evangelia, de Hoogh, Kees, Brunekreef, Bert, and Hoek, Gerard
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Additional file 1: Table S1. Study population selection. Table S2. Exposure distributions. Table S3. Spearman correlations between exposures (top), and between exposures and neighbourhood socio-economic position (SEP) score (bottom). Table S4. Mean exposure by quintiles of neighbourhood socio-economic position. Table S5. Hazard ratios (95% confidence intervals) for single exposure associations between air pollution and noise exposures and mortality by cause, with increasing level of covariate adjustment in single exposure models. Table S6. Effect modification by sex, hazard ratios (95% confidence intervals) in two exposure models for associations with natural cause mortality (Model 3). Table S7. Non-mover analysis, hazard ratios (95% confidence intervals) in two exposure models for associations with natural cause mortality (Model 3).
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- 2023
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15. Swiss Cohort & Biobank - The White Paper [statement]
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Probst-Hensch, Nicole, Bochud, Murielle, Chiolero, Arnaud, Crivelli, Luca, Dratva, Julia, Flahault, Antoine, Frey, Daniel, Kuenzli, Nino, Puhan, Milo, Suggs, L Suzanne, and Wirth, Corina
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360 Social problems & social services ,610 Medicine & health - Published
- 2022
16. Genome-wide analyses identify SCN5A as a susceptibility locus for premature atrial contraction frequency
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Thériault, Sébastien, Imboden, Medea, Biggs, Mary L, Austin, Thomas R, Aeschbacher, Stefanie, Schaffner, Emmanuel, Brody, Jennifer A, Bartz, Traci M, Risch, Martin, Grossmann, Kirsten, Lin, Henry J, Soliman, Elsayed Z, Post, Wendy S, Risch, Lorenz, Krieger, Jose E, Pereira, Alexandre C, Heckbert, Susan R, Sotoodehnia, Nona, Probst-Hensch, Nicole M, and Conen, David
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Multidisciplinary ,610 Medicine & health ,610 Medizin und Gesundheit - Abstract
Premature atrial contractions (PACs) are frequently observed on electrocardiograms and are associated with increased risks of atrial fibrillation (AF), stroke, and mortality. In this study, we aimed to identify genetic susceptibility loci for PAC frequency. We performed a genome-wide association study meta-analysis with PAC frequency obtained from ambulatory cardiac monitoring in 4,831 individuals of European ancestry. We identified a genome-wide significant locus at the SCN5A gene. The lead variant, rs7373862, located in an intron of SCN5A, was associated with an increase of 0.12 [95% CI 0.08-0.16] standard deviations of the normalized PAC frequency per risk allele. Among genetic variants previously associated with AF, there was a significant enrichment in concordance of effect for PAC frequency (n = 73/106, p = 5.1 x 10(-5)). However, several AF risk loci, including PITX2, were not associated with PAC frequency. These findings suggest the existence of both shared and distinct genetic mechanisms for PAC frequency and AF.
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- 2022
17. Socioeconomic factors influencing intimate partner violence among adolescents and young women in sub-Saharan Africa: A scoping review
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IKUTEYIJO, Olutoyin, Zepro, Nejimu, Probst-Hensch, Nicole, and Merten, Sonja
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Background: The age of adolescence in sub-Saharan Africa (SSA) could be especially challenging for girls given the double vulnerability arising from their gender and master status as young people growing in a patriarchal environment. Violence has been recorded as the second leading cause of death among adolescents and young people in the world. The ripple effect of experiencing intimate partner violence (IPV) at this period of life will affect physical, psychological as well as the socioeconomic status of adolescents and young women (AYW) in the future to come. Methods: A scoping review methodology will be used to address the broad exploratory nature of the research question. Online databases will be used to identify studies published between 2015 and 2022. The reporting procedure will be Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) as a checklist extension for the scoping review. Primary studies will be assessed using the Mixed Method Appraisal Tool, Version 2018. The following electronic databases: MEDLINE, Embase, PsycINFO, CINAHL, Cochrane Central, Sociological Abstracts, Web of Science, and the African Index Medicus will be used. All the articles retrieved will be imported to the Covidence platform for analysis by screening selected relevant studies. Discussion: It remain imperative to look at the extent of socioeconomic factors influencing IPV among adolescent and young women. This will lead to more effective solution to IPV against adolescent and young women.
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- 2022
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18. D15.6 - Results of the joint survey on HBM mixtures
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Ottenbros, Ilse, Lebret, Erik, Huber, Carolin, Lommen, Arjen, Antignac, Jean-Philippe, Čupr, Pavel, Šulc, Libor, Szigeti, Tamás, Középesy, Szilvia, Martinsone, Inese, Martinsone, Zanna, Pardo, Olga, Fernández, Sandra, Coscollá, Clara, Pedraza Diaz, Susana, Ammann, Priska, Jacobs, Anne, Probst-Hensch, Nicole, Imboden, Medea, Keidel, Dirk, Krauss, Martin, Debrauwer, Laurent, Wagner, Kevin, Nijssen, Rosalie, Mol, Hans, Vitale, Chiara Maria, Klanova, Jana, Garlito, Borja, León, Nuria, Luijten, Mirjam, and Vlaanderen, Jelle
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This deliverable describes the results of the joint pesticide survey ’SPECIMEn’ in five partner countries: Czech Republic, Hungary, Latvia, Spain and the Netherlands. It also contains a report on the implementation of a study conducted in Switzerland, which has a different design, but data was harmonised as much as possible. In all participating partner countries, urine samples have been collected in two seasons, i.e., winter 2019/2020 and summer 2020. Per country at least 100 locations have been included, of which about half are located in so-called hotspot areas. On the collected urine samples, a harmonised suspect screening method was applied to detect multiple pesticide-related markers. The deliverable describes the results obtained with this analysis.
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- 2022
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19. Air pollution, metabolites and respiratory health across the life-course
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Gruzieva, Olena, Jeong, Ayoung, He, Shizhen, Yu, Zhebin, de Bont, Jeroen, Pinho, Maria G. M., Eze, Ikenna C., Kress, Sara, Wheelock, Craig E., Peters, Annette, Vlaanderen, Jelle, de Hoogh, Kees, Scalbert, Augustin, Chadeau-Hyam, Marc, Vermeulen, Roel C. H., Gehring, Ulrike, Probst-Hensch, Nicole, Melén, Erik, Epidemiology and Data Science, APH - Health Behaviors & Chronic Diseases, APH - Methodology, and IRAS OH Epidemiology Chemical Agents
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Adult ,Air Pollutants ,Cross-Sectional Studies ,Air Pollution ,Air Pollutants/adverse effects ,Humans ,Particulate Matter ,Environmental Exposure ,Air Pollution/adverse effects ,Child ,Environmental Exposure/adverse effects - Abstract
Previous studies have explored the relationships of air pollution and metabolic profiles with lung function. However, the metabolites linking air pollution and lung function and the associated mechanisms have not been reviewed from a life-course perspective. Here, we provide a narrative review summarising recent evidence on the associations of metabolic profiles with air pollution exposure and lung function in children and adults. Twenty-six studies identified through a systematic PubMed search were included with 10 studies analysing air pollution-related metabolic profiles and 16 studies analysing lung function-related metabolic profiles. A wide range of metabolites were associated with short- and long-term exposure, partly overlapping with those linked to lung function in the general population and with respiratory diseases such as asthma and COPD. The existing studies show that metabolomics offers the potential to identify biomarkers linked to both environmental exposures and respiratory outcomes, but many studies suffer from small sample sizes, cross-sectional designs, a preponderance on adult lung function, heterogeneity in exposure assessment, lack of confounding control and omics integration. The ongoing EXposome Powered tools for healthy living in urbAN Settings (EXPANSE) project aims to address some of these shortcomings by combining biospecimens from large European cohorts and harmonised air pollution exposure and exposome data.
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- 2022
20. Moderating role of activity on body composition in hypertensive South African children in disadvantaged areas
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Joubert, Nandi, Walter, Cheryl, Du Randt, Rosa, Aerts, Ann, Adams, Larissa, Degen, Jan, Gall, Stefanie, M��ller, Ivan, Nienaber, Madeleine, Nqweniso, Siphesihle, Des Rosiers, Sarah, Seelig, Harald, Smith, Danielle, Steinmann, Peter, Probst-Hensch, Nicole, Utzinger, J��rg, P��hse, Uwe, and Gerber, Markus
- Abstract
Background: Childhood hypertension drives hypertension in later life; hence, assessing blood pressure in children is an important measure to determine current and future cardiovascular health. There is, however, a paucity of childhood blood pressure data, particularly for sub-Saharan Africa. Purpose: This study explores blood pressure and associations with age, sex, socioeconomic status, physical activity, fitness, and cardiovascular risk markers. Methods: In the ���Disease, Activity and Schoolchildren���s Health��� (DASH) study, a cross-sectional analysis was conducted in disadvantaged neighbourhoods in the Eastern Cape province of South Africa. Assessments included blood pressure, accelerometer-measured physical activity, physical fitness, and cardiovascular risk markers. Results: The study consisted of 785 children (383 boys, 402 girls, M = 12.4��0.9 years). Overall, 18% of the children were classified as hypertensive, while 20% were either overweight/obese, and almost four out of ten children did not meet global daily physical activity recommendations. Hypertensive children were more likely to be overweight/obese, ��2 (2,785) = 14.42, p < 0.01, but only if they did not meet physical activity recommendations, ��2 (2,295) = 11.93, p < 0.01 (Figure 1). Conclusion: Considering the moderating effect which sufficient activity has on the relationship between hypertension and body weight, more emphasis should be placed on holistic early primary health intervention and education strategies. Funding: This work was conducted within the scope of the Swiss-South African Joint Research Programme, jointly funded by the Swiss National Science Foundation and the National Research Foundation of South Africa. The cross-sectional study was further supported by the Novartis Foundation (Basel, Switzerland)., The Health & Fitness Journal of Canada, Vol. 14 No. 3 (2021): Proceedings from the 8th International Society for Physical Activity and Health Congress
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- 2022
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21. Additional file 1 of Perceived barriers to physical activity behaviour among patients with diabetes and hypertension in Kosovo: a qualitative study
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Bytyci Katanolli, Ariana, Probst-Hensch, Nicole, Ann Obas, Katrina, Gerold, Jana, Zahorka, Manfred, Jerliu, Naim, Ramadani, Qamile, Fota, Nicu, and Merten, Sonja
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Additional file 1.
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- 2022
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22. Results of the joint survey on HBM mixtures Deliverable Report D15.6 WP15 Mixtures, HBM and human health risks
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Mirjiam Luijten, Lebret, Erik, Huber, Carolin, Jean-Philippe Antignac, Cupr, Pavel, Sulc, Libor, Szigeti, Tamas, Kozepesy, Szilvia, Martinsone, Inese, Martinsone, Zanna, Pardo, Olga, Fernández, Sandra F., Coscollà, Clara, Pedraza, Susana, Ammann, Priska, Jacobs, Anne, Probst-Hensch, Nicole, Imboden, Medea, Keidel, Dirk, Krauss, Martin, Debrauwer, Laurent, Wagner, Kevin, Nijssen, Rosalie, H. G.J. Mol, Vitale, Chiara Maria, Klanova, Jana, Molina, Borja Garlito, and León, Nuria
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- 2022
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23. Additional file 2 of Impact of a school-based health intervention program on body composition among South African primary schoolchildren: results from the KaziAfya cluster-randomized controlled trial
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Long, Kurt Z., Beckmann, Johanna, Lang, Christin, Seelig, Harald, Nqweniso, Siphesihle, Probst-Hensch, Nicole, M��ller, Ivan, P��hse, Uwe, Steinmann, Peter, du Randt, Rosa, Walter, Cheryl, Utzinger, J��rg, and Gerber, Markus
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Data_FILES ,InformationSystems_DATABASEMANAGEMENT - Abstract
Additional file 2. Package insert of multi-vitamin mineral supplement tablets.
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- 2022
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24. Additional file 2 of Non-communicable disease prevention in Kosovo: quantitative and qualitative assessment of uptake and barriers of an intervention for healthier lifestyles in primary healthcare
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Bytyci-Katanolli, Ariana, Merten, Sonja, Kwiatkowski, Marek, Obas, Katrina, Gerold, Jana, Zahorka, Manfred, Jerliu, Naim, Ramadani, Qamile, Fota, Nicu, and Probst-Hensch, Nicole
- Abstract
Additional file 2: Table S1. Stages of change for physical inactivity and unhealthy eaters comparing intervention and non-intervention municipalities among obese participants, overall and by presence/absence of at least one self-reported doctor’s diagnosis (diabetes, hypertension, CVD).
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- 2022
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25. Additional file 1 of Association between mother’s work status and child stunting in urban slums: a cross-sectional assessment of 346 child-mother dyads in Dhaka, Bangladesh (2020)
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Win, Hayman, Shafique, Sohana, Mizan, Sharmin, Wallenborn, Jordyn, Probst-Hensch, Nicole, and Fink, Günther
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Additional file 1: Appendix 1. Descriptive statistics comparing selected imputations and observed data. Appendix 2. Background characteristics (full sample). Appendix 3. Nature of work and caregiving among currently working mothers. Appendix 4. Age-specific stunting by maternal work status. Appendix 5. Comparison on proportion of currently working mothers in study’s sample with population-representative data.
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- 2022
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26. Additional file 1 of Impact of a school-based health intervention program on body composition among South African primary schoolchildren: results from the KaziAfya cluster-randomized controlled trial
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Long, Kurt Z., Beckmann, Johanna, Lang, Christin, Seelig, Harald, Nqweniso, Siphesihle, Probst-Hensch, Nicole, M��ller, Ivan, P��hse, Uwe, Steinmann, Peter, du Randt, Rosa, Walter, Cheryl, Utzinger, J��rg, and Gerber, Markus
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humanities - Abstract
Additional file 1. CONSORT 2010 checklist of information to include when reporting a cluster randomised trial*.
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- 2022
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27. Additional file 1 of Non-communicable disease prevention in Kosovo: quantitative and qualitative assessment of uptake and barriers of an intervention for healthier lifestyles in primary healthcare
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Bytyci-Katanolli, Ariana, Merten, Sonja, Kwiatkowski, Marek, Obas, Katrina, Gerold, Jana, Zahorka, Manfred, Jerliu, Naim, Ramadani, Qamile, Fota, Nicu, and Probst-Hensch, Nicole
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Data_FILES - Abstract
Additional file 1: Figure 1. Coding Tree.
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- 2022
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28. Sleep spindle characteristics and arousability from nighttime transportation noise exposure in healthy young and older individuals
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Rudzik, Franziska, Thiesse, Laurie, Pieren, Reto, Wunderli, Jean Marc, Brink, Mark, Foraster, Maria, Héritier, Harris, Eze, Ikenna C., Garbazza, Corrado, Vienneau, Danielle, Probst-Hensch, Nicole, Röösli, Martin, and Cajochen, Christian
- Abstract
Study Objectives Nighttime transportation noise elicits awakenings, sleep-stage changes, and electroencephalographic (EEG) arousals. Here, we investigated the potential sleep-protective role of sleep spindles on noise-induced sleep alterations. Methods Twenty-six young (19-33 years, 12 women) and 18 older (52-70 years, 9 women) healthy volunteers underwent a repeated measures polysomnographic 6-day laboratory study. Participants spent one noise-free baseline night, followed by four transportation noise-exposure nights (road traffic or railway noise; continuous or intermittent: average sound levels of 45 dB, maximum sound levels of 50-62 dB), and one noise-free recovery night. Sleep stages were scored manually and fast sleep spindle characteristics were quantified automatically using an individual band-pass filtering approach. Results Nighttime exposure to transportation noise significantly increased sleep EEG arousal indices. Sleep structure and continuity were not differentially affected by noise exposure in individuals with a low versus a high spindle rate. Spindle rates showed an age-related decline along with more noise-induced sleep alterations. All-night spindle rates did not predict EEG arousal or awakening probability from single railway noise events. Spindle characteristics were affected in noise-exposure nights compared to noise-free nights: we observed a reduction of the spindle amplitude in both age groups and of the spindle rate in the older group. Conclusions We have evidence that spindle rate is more likely to represent a trait phenomenon, which does not seem to play a sleep-protective role in nighttime transportation noise-induced sleep disruptions. However, the marked reduction in spindle amplitude is most likely a sensitive index for noise-induced sleep alterations.
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- 2021
29. Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
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McCartney, Daniel L, Min, Josine L, Richmond, Rebecca C, Lu, Ake T, Sobczyk, Maria K, Davies, Gail, Broer, Linda, Guo, Xiuqing, Jeong, Ayoung, Jung, Jeesun, Kasela, Silva, Katrinli, Seyma, Kuo, Pei-Lun, Matias-Garcia, Pamela R, Mishra, Pashupati P, Nygaard, Marianne, Palviainen, Teemu, Patki, Amit, Raffield, Laura M, Ratliff, Scott M, Richardson, Tom G, Robinson, Oliver, Soerensen, Mette, Sun, Dianjianyi, Tsai, Pei-Chien, van der Zee, Matthijs D, Walker, Rosie M, Wang, Xiaochuan, Wang, Yunzhang, Xia, Rui, Xu, Zongli, Yao, Jie, Zhao, Wei, Correa, Adolfo, Boerwinkle, Eric, Dugué, Pierre-Antoine, Durda, Peter, Elliott, Hannah R, Gieger, Christian, Genetics of DNA Methylation Consortium, de Geus, Eco JC, Harris, Sarah E, Hemani, Gibran, Imboden, Medea, Kähönen, Mika, Kardia, Sharon LR, Kresovich, Jacob K, Li, Shengxu, Lunetta, Kathryn L, Mangino, Massimo, Mason, Dan, McIntosh, Andrew M, Mengel-From, Jonas, Moore, Ann Zenobia, Murabito, Joanne M, NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Ollikainen, Miina, Pankow, James S, Pedersen, Nancy L, Peters, Annette, Polidoro, Silvia, Porteous, David J, Raitakari, Olli, Rich, Stephen S, Sandler, Dale P, Sillanpää, Elina, Smith, Alicia K, Southey, Melissa C, Strauch, Konstantin, Tiwari, Hemant, Tanaka, Toshiko, Tillin, Therese, Uitterlinden, Andre G, Van Den Berg, David J, van Dongen, Jenny, Wilson, James G, Wright, John, Yet, Idil, Arnett, Donna, Bandinelli, Stefania, Bell, Jordana T, Binder, Alexandra M, Boomsma, Dorret I, Chen, Wei, Christensen, Kaare, Conneely, Karen N, Elliott, Paul, Ferrucci, Luigi, Fornage, Myriam, Hägg, Sara, Hayward, Caroline, Irvin, Marguerite, Kaprio, Jaakko, Lawlor, Deborah A, Lehtimäki, Terho, Lohoff, Falk W, Milani, Lili, Milne, Roger L, Probst-Hensch, Nicole, and Reiner, Alex P
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Genetic Markers ,Aging ,Multifactorial Inheritance ,Epigenetic clock ,Bioinformatics ,NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium ,Genetic ,Information and Computing Sciences ,Plasminogen Activator Inhibitor 1 ,Genetics ,Humans ,Innate ,GWAS ,Adiposity ,Nutrition ,Genome ,DNA methylation ,Prevention ,Inflammatory and immune system ,Human Genome ,Immunity ,Genetics of DNA Methylation Consortium ,Biological Sciences ,Lipid Metabolism ,C-Reactive Protein ,Good Health and Well Being ,Genetic Loci ,Educational Status ,CpG Islands ,Generic health relevance ,Biomarkers ,Environmental Sciences ,Granulocytes ,Epigenesis ,Human ,Genome-Wide Association Study - Abstract
BackgroundBiological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation in these measures in populations has become a major goal in the field.ResultsLeveraging DNA methylation and SNP data from more than 40,000 individuals, we identify 137 genome-wide significant loci, of which 113 are novel, from genome-wide association study (GWAS) meta-analyses of four epigenetic clocks and epigenetic surrogate markers for granulocyte proportions and plasminogen activator inhibitor 1 levels, respectively. We find evidence for shared genetic loci associated with the Horvath clock and expression of transcripts encoding genes linked to lipid metabolism and immune function. Notably, these loci are independent of those reported to regulate DNA methylation levels at constituent clock CpGs. A polygenic score for GrimAge acceleration showed strong associations with adiposity-related traits, educational attainment, parental longevity, and C-reactive protein levels.ConclusionThis study illuminates the genetic architecture underlying epigenetic aging and its shared genetic contributions with lifestyle factors and longevity.
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- 2021
30. Concept for a Study Protocol focusing on Recruitment, Fieldwork and Sampling
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Fiddicke, Ulrike, Pack, L. Kim, Åkesson, Agneta, Berglund, Marika, Bergström, Anna, Esteban Lopez, Marta, Filippini, Tommaso, Govarts, Eva, Hansen, Sofie, Koppen, Gudrun, Leander, Karin, Moshammer, Hanns, Probst-Hensch, Nicole, Ramboud, Loïc, Remy, Sylvie, Schernhammer, Eva, Vinceti, Marco, Castaño, Argelia, González-Alzaga, Beatriz, Lacasaña, Marina, and Schoeters, Greet
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HBM4EU ,HBM study ,Human Biomonitoring ,study material ,template ,study protocol - Abstract
This concept for a Study Protocol introduces a phases-concept to facilitate the evolution of environmental studies. It provides a template or model for the conduct of human biomonitoring (HBM) studies while focussing on recruitment, fieldwork, and sampling. It can be used for both the setup of new studies as well as to check protocols of already ongoing studies. This concept aims to address all steps that are worth considering when preparing a HBM study and provides a model to help identifying and filling such a study's different phases. This document is also included as an annex in HBM4EU Deliverable D7.3.
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- 2021
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31. Residential exposure to greenspace and life satisfaction in times of COVID-19: a cross-sectional analysis of 9444 participants from a population-based study in Basel-Stadt and Basel-Landschaft
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Jeong, Ayoung, Galliker, Fiona, Imboden, Medea, Keidel, Dirk, de Hoogh, Kees, Vienneau, Danielle, Siegrist, Michael, Crivelli, Luca, Lovison, Gianfranco, and Probst-Hensch, Nicole
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Adult ,Young Adult ,Cross-Sectional Studies ,Adolescent ,Parks, Recreational ,COVID-19 ,Humans ,Personal Satisfaction ,General Medicine ,Pandemics - Abstract
BACKGROUND: Subjective well-being is an important target in the COVID-19 pandemic. Residential greenness may help cope with stress and hence influence subjective well-being during this mentally and physically challenging time. METHODS: We analysed the association between residential greenness and life satisfaction in 9,444 adults in the COVCO-Basel cohort. We assessed if the association is modified by age, sex, household income, financial worries, canton of residence, or month of study entry. In addition, we assessed if the association is attributed to specific types of greenspace or accessibility to greenspace. RESULTS: The association between residential greenness and life satisfaction varied by age groups, household income, and financial worries. Residential greenness was positively associated with life satisfaction in those with high household income and the least financially worried, and negatively associated with life satisfaction in the youngest age group (18–29 years) and the most financially worried. Living closer to a forest, but not to a park or an agricultural area, was associated with lower life satisfaction in the youngest age group. CONCLUSIONS: Residential greenness effects on life satisfaction vary according to sociodemographic characteristics. Living in a greener area does not benefit all dwellers in Basel and its region equally, with the most apparent benefit for those with high household income and without financial concerns., Swiss Medical Weekly, 152, ISSN:1424-7860, ISSN:1424-3997
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- 2022
32. Additional file 1 of Understanding urban inequalities in children���s linear growth outcomes: a trend and decomposition analysis of 39,049 children in Bangladesh (2000-2018)
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Win, Hayman, Wallenborn, Jordyn, Probst-Hensch, Nicole, and Fink, G��nther
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Additional file 1. Supplementary material
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- 2021
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33. Additional file 1 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
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McCartney, Daniel L., Min, Josine L., Richmond, Rebecca C., Lu, Ake T., Sobczyk, Maria K., Davies, Gail, Broer, Linda, Guo, Xiuqing, Jeong, Ayoung, Jung, Jeesun, Kasela, Silva, Katrinli, Seyma, Kuo, Pei-Lun, Matias-Garcia, Pamela R., Mishra, Pashupati P., Nygaard, Marianne, Palviainen, Teemu, Patki, Amit, Raffield, Laura M., Ratliff, Scott M., Richardson, Tom G., Robinson, Oliver, Soerensen, Mette, Sun, Dianjianyi, Tsai, Pei-Chien, van der Zee, Matthijs D., Walker, Rosie M., Wang, Xiaochuan, Wang, Yunzhang, Xia, Rui, Xu, Zongli, Yao, Jie, Zhao, Wei, Correa, Adolfo, Boerwinkle, Eric, Dugué, Pierre-Antoine, Durda, Peter, Elliott, Hannah R., Gieger, Christian, de Geus, Eco J. C., Harris, Sarah E., Hemani, Gibran, Imboden, Medea, Kähönen, Mika, Kardia, Sharon L. R., Kresovich, Jacob K., Li, Shengxu, Lunetta, Kathryn L., Mangino, Massimo, Mason, Dan, McIntosh, Andrew M., Mengel-From, Jonas, Moore, Ann Zenobia, Murabito, Joanne M., Ollikainen, Miina, Pankow, James S., Pedersen, Nancy L., Peters, Annette, Polidoro, Silvia, Porteous, David J., Raitakari, Olli, Rich, Stephen S., Sandler, Dale P., Sillanpää, Elina, Smith, Alicia K., Southey, Melissa C., Strauch, Konstantin, Tiwari, Hemant, Tanaka, Toshiko, Tillin, Therese, Uitterlinden, Andre G., Van Den Berg, David J., van Dongen, Jenny, Wilson, James G., Wright, John, Yet, Idil, Arnett, Donna, Bandinelli, Stefania, Bell, Jordana T., Binder, Alexandra M., Boomsma, Dorret I., Chen, Wei, Christensen, Kaare, Conneely, Karen N., Elliott, Paul, Ferrucci, Luigi, Fornage, Myriam, Hägg, Sara, Hayward, Caroline, Irvin, Marguerite, Kaprio, Jaakko, Lawlor, Deborah A., Lehtimäki, Terho, Lohoff, Falk W., Milani, Lili, Milne, Roger L., Probst-Hensch, Nicole, Reiner, Alex P., Ritz, Beate, Rotter, Jerome I., Smith, Jennifer A., Taylor, Jack A., van Meurs, Joyce B. J., Vineis, Paolo, Waldenberger, Melanie, Deary, Ian J., Relton, Caroline L., Horvath, Steve, and Marioni, Riccardo E.
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Additional file 1. Individual cohort descriptions and acknowledgements.
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34. Additional file 5 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
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McCartney, Daniel L., Min, Josine L., Richmond, Rebecca C., Lu, Ake T., Sobczyk, Maria K., Davies, Gail, Broer, Linda, Guo, Xiuqing, Jeong, Ayoung, Jung, Jeesun, Kasela, Silva, Katrinli, Seyma, Kuo, Pei-Lun, Matias-Garcia, Pamela R., Mishra, Pashupati P., Nygaard, Marianne, Palviainen, Teemu, Patki, Amit, Raffield, Laura M., Ratliff, Scott M., Richardson, Tom G., Robinson, Oliver, Soerensen, Mette, Sun, Dianjianyi, Tsai, Pei-Chien, van der Zee, Matthijs D., Walker, Rosie M., Wang, Xiaochuan, Wang, Yunzhang, Xia, Rui, Xu, Zongli, Yao, Jie, Zhao, Wei, Correa, Adolfo, Boerwinkle, Eric, Dugué, Pierre-Antoine, Durda, Peter, Elliott, Hannah R., Gieger, Christian, de Geus, Eco J. C., Harris, Sarah E., Hemani, Gibran, Imboden, Medea, Kähönen, Mika, Kardia, Sharon L. R., Kresovich, Jacob K., Li, Shengxu, Lunetta, Kathryn L., Mangino, Massimo, Mason, Dan, McIntosh, Andrew M., Mengel-From, Jonas, Moore, Ann Zenobia, Murabito, Joanne M., Ollikainen, Miina, Pankow, James S., Pedersen, Nancy L., Peters, Annette, Polidoro, Silvia, Porteous, David J., Raitakari, Olli, Rich, Stephen S., Sandler, Dale P., Sillanpää, Elina, Smith, Alicia K., Southey, Melissa C., Strauch, Konstantin, Tiwari, Hemant, Tanaka, Toshiko, Tillin, Therese, Uitterlinden, Andre G., Van Den Berg, David J., van Dongen, Jenny, Wilson, James G., Wright, John, Yet, Idil, Arnett, Donna, Bandinelli, Stefania, Bell, Jordana T., Binder, Alexandra M., Boomsma, Dorret I., Chen, Wei, Christensen, Kaare, Conneely, Karen N., Elliott, Paul, Ferrucci, Luigi, Fornage, Myriam, Hägg, Sara, Hayward, Caroline, Irvin, Marguerite, Kaprio, Jaakko, Lawlor, Deborah A., Lehtimäki, Terho, Lohoff, Falk W., Milani, Lili, Milne, Roger L., Probst-Hensch, Nicole, Reiner, Alex P., Ritz, Beate, Rotter, Jerome I., Smith, Jennifer A., Taylor, Jack A., van Meurs, Joyce B. J., Vineis, Paolo, Waldenberger, Melanie, Deary, Ian J., Relton, Caroline L., Horvath, Steve, and Marioni, Riccardo E.
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Additional file 5. Colocalization plots.
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- 2021
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35. Loneliness in older persons throughout the COVID-19 pandemic in Switzerland
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Meier, Flurina, Heiniger, Sarah, Probst-Hensch, Nicole, and Höglinger, Marc
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150: Psychologie ,614: Public Health und Gesundheitsförderung - Abstract
Background: Loneliness is associated with adverse health outcomes in older people such as mortality, cardiovascular diseases, depression and dementia (Holt-Lunstad et al., 2015; Lambert Van As, et al., 2021; Lara et al., 2019; Valtorta et al., 2016). Before the COVID-19 pandemic about 4.7% of persons aged 65 years and older felt often or very often lonely and another 26.7% felt sometimes lonely in Switzerland (Hämmig, 2019). During the COVID-19 pandemic older persons’ mobility and social contacts have been restricted to a large extent. Several studies showed that the COVID-19 pandemic and restriction measures taken to contain it led to more feelings of loneliness in older persons during the first weeks and month of the pandemic compared to before the outbreak (e.g. Kotwal et al., 2021; Macdonald & Hülür, 2021; Seifert & Hassler, 2020). However, none of these studies had follow-ups of more than 15 weeks. Therefore, we investigated older persons’ feelings of loneliness over 15 month (between March 2020 and June 2021) to describe its development throughout the COVID-19 pandemic and in changing situations, e.g. with regards to restrictions. Methods: The COVID-19 Social Monitor is a longitudinal online panel survey of the Swiss population. Participants were randomly selected and actively recruited from an existing panel pool (LINK Institute, Zurich, Switzerland). Participants were surveyed every 2-5 weeks since March 30th 2020 and data collection is still ongoing. For the present analyses data from March 30th 2020 to June 17th 2021 was used. We used two different measures of loneliness: the 3-item UCLA loneliness scale (Hughes, 2004) and a direct question on feelings of loneliness (i.e. How often do you currently feel lonely?) as used in the Swiss Health Survey. Results: 304 persons between 65 and 79 years participated between March and November 2020 and 506 between December 2020 and June 2021. Response rates were between 73% and 91% in the former and between 78% and 92% in the latter time period. Preliminary descriptive analyses show that the percentage of older persons that felt lonely during the lockdown periods in spring (between March 16th and May 4th) and fall/winter (between October 29th and May 31st) was higher than the percentage of older persons having such feeling between or after lockdown periods. This can be seen in both measures used: the 3-item UCLA loneliness scale as well as the direct measure of loneliness. The examined population mostly felt a lack of companionship throughout lockdowns (data not shown). Further analyses are planned to tackle time trends, significance of these differences in time and differences in subgroups. Conclusion: Our descriptive analyses show that in the spring and fall/winter lockdown more older people in Switzerland seem to have felt lonely than in time periods between and after these lockdowns. Compared to data from the Swiss Health Survey 2012 that found 4.7% of persons aged 65 years and older feeling often or very often lonely (Hämmig, 2019), the prevalence seems to have been higher during lockdown periods but not throughout summer 2020. This suggests, that feelings of loneliness increased during the pandemic, but the increase was limited to phases with severe restrictions regarding mobility and social contacts.
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- 2021
36. Additional file 5 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
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McCartney, Daniel L., Min, Josine L., Richmond, Rebecca C., Lu, Ake T., Sobczyk, Maria K., Davies, Gail, Broer, Linda, Guo, Xiuqing, Jeong, Ayoung, Jung, Jeesun, Kasela, Silva, Katrinli, Seyma, Kuo, Pei-Lun, Matias-Garcia, Pamela R., Mishra, Pashupati P., Nygaard, Marianne, Palviainen, Teemu, Patki, Amit, Raffield, Laura M., Ratliff, Scott M., Richardson, Tom G., Robinson, Oliver, Soerensen, Mette, Sun, Dianjianyi, Tsai, Pei-Chien, van der Zee, Matthijs D., Walker, Rosie M., Wang, Xiaochuan, Wang, Yunzhang, Xia, Rui, Xu, Zongli, Yao, Jie, Zhao, Wei, Correa, Adolfo, Boerwinkle, Eric, Dugué, Pierre-Antoine, Durda, Peter, Elliott, Hannah R., Gieger, Christian, de Geus, Eco J. C., Harris, Sarah E., Hemani, Gibran, Imboden, Medea, Kähönen, Mika, Kardia, Sharon L. R., Kresovich, Jacob K., Li, Shengxu, Lunetta, Kathryn L., Mangino, Massimo, Mason, Dan, McIntosh, Andrew M., Mengel-From, Jonas, Moore, Ann Zenobia, Murabito, Joanne M., Ollikainen, Miina, Pankow, James S., Pedersen, Nancy L., Peters, Annette, Polidoro, Silvia, Porteous, David J., Raitakari, Olli, Rich, Stephen S., Sandler, Dale P., Sillanpää, Elina, Smith, Alicia K., Southey, Melissa C., Strauch, Konstantin, Tiwari, Hemant, Tanaka, Toshiko, Tillin, Therese, Uitterlinden, Andre G., Van Den Berg, David J., van Dongen, Jenny, Wilson, James G., Wright, John, Yet, Idil, Arnett, Donna, Bandinelli, Stefania, Bell, Jordana T., Binder, Alexandra M., Boomsma, Dorret I., Chen, Wei, Christensen, Kaare, Conneely, Karen N., Elliott, Paul, Ferrucci, Luigi, Fornage, Myriam, Hägg, Sara, Hayward, Caroline, Irvin, Marguerite, Kaprio, Jaakko, Lawlor, Deborah A., Lehtimäki, Terho, Lohoff, Falk W., Milani, Lili, Milne, Roger L., Probst-Hensch, Nicole, Reiner, Alex P., Ritz, Beate, Rotter, Jerome I., Smith, Jennifer A., Taylor, Jack A., van Meurs, Joyce B. J., Vineis, Paolo, Waldenberger, Melanie, Deary, Ian J., Relton, Caroline L., Horvath, Steve, and Marioni, Riccardo E.
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Additional file 5. Colocalization plots.
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37. Additional file 6 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
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McCartney, Daniel L., Min, Josine L., Richmond, Rebecca C., Lu, Ake T., Sobczyk, Maria K., Davies, Gail, Broer, Linda, Guo, Xiuqing, Jeong, Ayoung, Jung, Jeesun, Kasela, Silva, Katrinli, Seyma, Kuo, Pei-Lun, Matias-Garcia, Pamela R., Mishra, Pashupati P., Nygaard, Marianne, Palviainen, Teemu, Patki, Amit, Raffield, Laura M., Ratliff, Scott M., Richardson, Tom G., Robinson, Oliver, Soerensen, Mette, Sun, Dianjianyi, Tsai, Pei-Chien, van der Zee, Matthijs D., Walker, Rosie M., Wang, Xiaochuan, Wang, Yunzhang, Xia, Rui, Xu, Zongli, Yao, Jie, Zhao, Wei, Correa, Adolfo, Boerwinkle, Eric, Dugué, Pierre-Antoine, Durda, Peter, Elliott, Hannah R., Gieger, Christian, de Geus, Eco J. C., Harris, Sarah E., Hemani, Gibran, Imboden, Medea, Kähönen, Mika, Kardia, Sharon L. R., Kresovich, Jacob K., Li, Shengxu, Lunetta, Kathryn L., Mangino, Massimo, Mason, Dan, McIntosh, Andrew M., Mengel-From, Jonas, Moore, Ann Zenobia, Murabito, Joanne M., Ollikainen, Miina, Pankow, James S., Pedersen, Nancy L., Peters, Annette, Polidoro, Silvia, Porteous, David J., Raitakari, Olli, Rich, Stephen S., Sandler, Dale P., Sillanpää, Elina, Smith, Alicia K., Southey, Melissa C., Strauch, Konstantin, Tiwari, Hemant, Tanaka, Toshiko, Tillin, Therese, Uitterlinden, Andre G., Van Den Berg, David J., van Dongen, Jenny, Wilson, James G., Wright, John, Yet, Idil, Arnett, Donna, Bandinelli, Stefania, Bell, Jordana T., Binder, Alexandra M., Boomsma, Dorret I., Chen, Wei, Christensen, Kaare, Conneely, Karen N., Elliott, Paul, Ferrucci, Luigi, Fornage, Myriam, Hägg, Sara, Hayward, Caroline, Irvin, Marguerite, Kaprio, Jaakko, Lawlor, Deborah A., Lehtimäki, Terho, Lohoff, Falk W., Milani, Lili, Milne, Roger L., Probst-Hensch, Nicole, Reiner, Alex P., Ritz, Beate, Rotter, Jerome I., Smith, Jennifer A., Taylor, Jack A., van Meurs, Joyce B. J., Vineis, Paolo, Waldenberger, Melanie, Deary, Ian J., Relton, Caroline L., Horvath, Steve, and Marioni, Riccardo E.
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Additional file 6. Review history.
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38. Additional file 1 of Mental health and resilience among Eritrean refugees at arrival and one-year post-registration in Switzerland: a cohort study
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Chernet, Afona, Probst-Hensch, Nicole, Sydow, Véronique, Paris, Daniel H., and Labhardt, Niklaus D.
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Additional file 1: Table S1. Mental health screening at baseline and one-year follow-up (N = 48).
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39. Additional file 6 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
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McCartney, Daniel L., Min, Josine L., Richmond, Rebecca C., Lu, Ake T., Sobczyk, Maria K., Davies, Gail, Broer, Linda, Guo, Xiuqing, Jeong, Ayoung, Jung, Jeesun, Kasela, Silva, Katrinli, Seyma, Kuo, Pei-Lun, Matias-Garcia, Pamela R., Mishra, Pashupati P., Nygaard, Marianne, Palviainen, Teemu, Patki, Amit, Raffield, Laura M., Ratliff, Scott M., Richardson, Tom G., Robinson, Oliver, Soerensen, Mette, Sun, Dianjianyi, Tsai, Pei-Chien, van der Zee, Matthijs D., Walker, Rosie M., Wang, Xiaochuan, Wang, Yunzhang, Xia, Rui, Xu, Zongli, Yao, Jie, Zhao, Wei, Correa, Adolfo, Boerwinkle, Eric, Dugué, Pierre-Antoine, Durda, Peter, Elliott, Hannah R., Gieger, Christian, de Geus, Eco J. C., Harris, Sarah E., Hemani, Gibran, Imboden, Medea, Kähönen, Mika, Kardia, Sharon L. R., Kresovich, Jacob K., Li, Shengxu, Lunetta, Kathryn L., Mangino, Massimo, Mason, Dan, McIntosh, Andrew M., Mengel-From, Jonas, Moore, Ann Zenobia, Murabito, Joanne M., Ollikainen, Miina, Pankow, James S., Pedersen, Nancy L., Peters, Annette, Polidoro, Silvia, Porteous, David J., Raitakari, Olli, Rich, Stephen S., Sandler, Dale P., Sillanpää, Elina, Smith, Alicia K., Southey, Melissa C., Strauch, Konstantin, Tiwari, Hemant, Tanaka, Toshiko, Tillin, Therese, Uitterlinden, Andre G., Van Den Berg, David J., van Dongen, Jenny, Wilson, James G., Wright, John, Yet, Idil, Arnett, Donna, Bandinelli, Stefania, Bell, Jordana T., Binder, Alexandra M., Boomsma, Dorret I., Chen, Wei, Christensen, Kaare, Conneely, Karen N., Elliott, Paul, Ferrucci, Luigi, Fornage, Myriam, Hägg, Sara, Hayward, Caroline, Irvin, Marguerite, Kaprio, Jaakko, Lawlor, Deborah A., Lehtimäki, Terho, Lohoff, Falk W., Milani, Lili, Milne, Roger L., Probst-Hensch, Nicole, Reiner, Alex P., Ritz, Beate, Rotter, Jerome I., Smith, Jennifer A., Taylor, Jack A., van Meurs, Joyce B. J., Vineis, Paolo, Waldenberger, Melanie, Deary, Ian J., Relton, Caroline L., Horvath, Steve, and Marioni, Riccardo E.
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Additional file 6. Review history.
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- 2021
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40. Additional file 4 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
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McCartney, Daniel L., Min, Josine L., Richmond, Rebecca C., Lu, Ake T., Sobczyk, Maria K., Davies, Gail, Broer, Linda, Guo, Xiuqing, Jeong, Ayoung, Jung, Jeesun, Kasela, Silva, Katrinli, Seyma, Kuo, Pei-Lun, Matias-Garcia, Pamela R., Mishra, Pashupati P., Nygaard, Marianne, Palviainen, Teemu, Patki, Amit, Raffield, Laura M., Ratliff, Scott M., Richardson, Tom G., Robinson, Oliver, Soerensen, Mette, Sun, Dianjianyi, Tsai, Pei-Chien, van der Zee, Matthijs D., Walker, Rosie M., Wang, Xiaochuan, Wang, Yunzhang, Xia, Rui, Xu, Zongli, Yao, Jie, Zhao, Wei, Correa, Adolfo, Boerwinkle, Eric, Dugué, Pierre-Antoine, Durda, Peter, Elliott, Hannah R., Gieger, Christian, de Geus, Eco J. C., Harris, Sarah E., Hemani, Gibran, Imboden, Medea, Kähönen, Mika, Kardia, Sharon L. R., Kresovich, Jacob K., Li, Shengxu, Lunetta, Kathryn L., Mangino, Massimo, Mason, Dan, McIntosh, Andrew M., Mengel-From, Jonas, Moore, Ann Zenobia, Murabito, Joanne M., Ollikainen, Miina, Pankow, James S., Pedersen, Nancy L., Peters, Annette, Polidoro, Silvia, Porteous, David J., Raitakari, Olli, Rich, Stephen S., Sandler, Dale P., Sillanpää, Elina, Smith, Alicia K., Southey, Melissa C., Strauch, Konstantin, Tiwari, Hemant, Tanaka, Toshiko, Tillin, Therese, Uitterlinden, Andre G., Van Den Berg, David J., van Dongen, Jenny, Wilson, James G., Wright, John, Yet, Idil, Arnett, Donna, Bandinelli, Stefania, Bell, Jordana T., Binder, Alexandra M., Boomsma, Dorret I., Chen, Wei, Christensen, Kaare, Conneely, Karen N., Elliott, Paul, Ferrucci, Luigi, Fornage, Myriam, Hägg, Sara, Hayward, Caroline, Irvin, Marguerite, Kaprio, Jaakko, Lawlor, Deborah A., Lehtimäki, Terho, Lohoff, Falk W., Milani, Lili, Milne, Roger L., Probst-Hensch, Nicole, Reiner, Alex P., Ritz, Beate, Rotter, Jerome I., Smith, Jennifer A., Taylor, Jack A., van Meurs, Joyce B. J., Vineis, Paolo, Waldenberger, Melanie, Deary, Ian J., Relton, Caroline L., Horvath, Steve, and Marioni, Riccardo E.
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Additional file 4. Assessment of genomic inflation and heterogeneity.
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41. Additional file 3 of Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
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McCartney, Daniel L., Min, Josine L., Richmond, Rebecca C., Lu, Ake T., Sobczyk, Maria K., Davies, Gail, Broer, Linda, Guo, Xiuqing, Jeong, Ayoung, Jung, Jeesun, Kasela, Silva, Katrinli, Seyma, Kuo, Pei-Lun, Matias-Garcia, Pamela R., Mishra, Pashupati P., Nygaard, Marianne, Palviainen, Teemu, Patki, Amit, Raffield, Laura M., Ratliff, Scott M., Richardson, Tom G., Robinson, Oliver, Soerensen, Mette, Sun, Dianjianyi, Tsai, Pei-Chien, van der Zee, Matthijs D., Walker, Rosie M., Wang, Xiaochuan, Wang, Yunzhang, Xia, Rui, Xu, Zongli, Yao, Jie, Zhao, Wei, Correa, Adolfo, Boerwinkle, Eric, Dugué, Pierre-Antoine, Durda, Peter, Elliott, Hannah R., Gieger, Christian, de Geus, Eco J. C., Harris, Sarah E., Hemani, Gibran, Imboden, Medea, Kähönen, Mika, Kardia, Sharon L. R., Kresovich, Jacob K., Li, Shengxu, Lunetta, Kathryn L., Mangino, Massimo, Mason, Dan, McIntosh, Andrew M., Mengel-From, Jonas, Moore, Ann Zenobia, Murabito, Joanne M., Ollikainen, Miina, Pankow, James S., Pedersen, Nancy L., Peters, Annette, Polidoro, Silvia, Porteous, David J., Raitakari, Olli, Rich, Stephen S., Sandler, Dale P., Sillanpää, Elina, Smith, Alicia K., Southey, Melissa C., Strauch, Konstantin, Tiwari, Hemant, Tanaka, Toshiko, Tillin, Therese, Uitterlinden, Andre G., Van Den Berg, David J., van Dongen, Jenny, Wilson, James G., Wright, John, Yet, Idil, Arnett, Donna, Bandinelli, Stefania, Bell, Jordana T., Binder, Alexandra M., Boomsma, Dorret I., Chen, Wei, Christensen, Kaare, Conneely, Karen N., Elliott, Paul, Ferrucci, Luigi, Fornage, Myriam, Hägg, Sara, Hayward, Caroline, Irvin, Marguerite, Kaprio, Jaakko, Lawlor, Deborah A., Lehtimäki, Terho, Lohoff, Falk W., Milani, Lili, Milne, Roger L., Probst-Hensch, Nicole, Reiner, Alex P., Ritz, Beate, Rotter, Jerome I., Smith, Jennifer A., Taylor, Jack A., van Meurs, Joyce B. J., Vineis, Paolo, Waldenberger, Melanie, Deary, Ian J., Relton, Caroline L., Horvath, Steve, and Marioni, Riccardo E.
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Additional file 3. Supplementary Figures - Figures S1-S31.
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42. Bevölkerungsbefragung Basel-Landschaft. Kantonaler Bericht
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Deschodt, Mieke, Siqeca, Flaka, Yip, Olivia, Stenz, Samuel, Mendieta Jara, Maria Jose, Blozik, Eva, Briel, Matthias, Obas, Kathrina, Probst-Hensch, Nicole, Quinto, Carlos, Vounatsou, Penelope, Schwenkglenks, Matthias, Zeller, Andy, Zuniga, Franziska, and De Geest, Sabina
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geriatrics ,survey ,community care - Abstract
status: published
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- 2020
43. Regular physical activity levels and incidence of restrictive spirometry pattern: a longitudinal analysis of two population-based cohorts
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Carsin, Anne-Elie, Keidel, Dirk, Fuertes, Elaine, Imboden, Medea, Weyler, Joost, Nowak, Dennis, Heinrich, Joachim, Pascual Erquicia Silvia, Martinez-Moratalla, Jesus, Huerta, Ismael, Sanchez, Jose-Luis, Schaffner, Emmanuel, Caviezel, Serena, Beckmeyer-Borowko, Anna, Raherison, Chantal, Pin, Isabelle, Demoly, Pascal, Leynaert, Bénédicte, Cerveri, Isa, Squillacioti, Giulia, Accordini, Simone, Gislason, Thorarinn, Svanes, Cecilie, Toren, Kjell, Forsberg, Bertil, Janson, Christer, Jogi, Rain, Emtner, Margareta, Gómez Real Francisco, Jarvis, Debbie, Guerra, Stefano, Dharmage Shyamali, C, Probst-Hensch, Nicole, Garcia-Aymerich, Judith, and European Union's Horizon 2020 research and innovation programme
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BMI ,FVC ,Physical activity ,restrictive spirometry ,spirometry ,Adult ,Aged, 80 and over ,Male ,Epidemiology ,Incidence ,Vital Capacity ,physical activity ,Middle Aged ,Respiration Disorders ,Europe ,Forced Expiratory Volume ,Humans ,Female ,Longitudinal Studies ,Exercise ,01 Mathematical Sciences ,11 Medical and Health Sciences ,Aged - Abstract
A restrictive spirometry pattern is associated with high morbidity and mortality. Whether practicing regular physical activity protects against this pattern has never been studied. We estimated the association between regular physical activity and the incidence of restrictive spirometry pattern. Forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC) and physical activity were assessed between 2000–2002 in the ECRHS (n=2,757, 39-67 years) and SAPALDIA (n=2,610, 36–82 years) population-based European cohorts, and again approximately 10-years later (2010–2013). Subjects with restrictive or obstructive spirometry pattern at baseline were excluded. We assessed the association of being active at baseline (defined as being physically active ≥2-3 times/wk for ≥1 h) with restrictive spirometry pattern at follow-up (defined as a post-bronchodilator FEV1/FVC ≥Lower Limit of Normal and FVC
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44. Additional file 1 of The modifying role of physical activity in the cross-sectional and longitudinal association of health-related quality of life with physiological functioning-based latent classes and metabolic syndrome
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Cerletti, Paco, Keidel, Dirk, Imboden, Medea, Schindler, Christian, and Probst-Hensch, Nicole
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Additional file 1: Additional Table 1. Baseline characteristics at SAPALDIA 1 of participants who reached the age of 55+ at the time of the SAPALDIA4 55+ health assessments, stratified by participation status in the current study. Additional Table 2. Summary of model fit indices for 1 to 6 latent classes at SAPALDIA4. Additional Table 3. Summary of model fit indices for 1 to 6 latent classes at SAPALDIA3. Additional Table 4. Proportions and class-specific probabilities for the 3 latent classes at SAPALDIA4. Additional Table 5. Proportions and class-specific probabilities for the 3 latent classes at SAPALDIA3. Additional Table 6. Descriptive differences in sex, age and education between the three latent classes, SAPALDIA4. Additional Table 6. Descriptive differences in sex, age and education between the three latent classes, SAPALDIA4. Additional Fig. 1. Descriptive differences of median HRQoL scores of the three latent classes (without adjustment for physical activity) at SAPALDIA4. Additional Table 7. Cross-sectional adjusted HQRoL associations of categories combining physical activity with latent classes (A7A) as well as metabolic syndrome (A7B) (SAPALDIA4). Additional Table 8. Cross-sectional associations of composite variable categories defined by latent classes (A8A) and metabolic syndrome (A8B), respectively, and physical activity status, with median levels of HRQoL, subjects not reporting any cardiovascular disease (SAPALDIA4). Additional Table 9. Prospective associations of composite variable categories defined by latent classes (A9A) and metabolic syndrome (A9B), respectively, and physical activity status at SAPALDIA3, with median levels of HRQoL at SAPALDIA4, adjusted for respective HRQoL domain at SAPALDIA3, subjects not reporting any cardiovascular at SAPALDIA4. Additional Table 10. Cross-sectional associations of composite variable categories defined by latent classes (A10A) and metabolic syndrome (A10B), respectively, and physical activity status with health service utilization in the last 12 months, subjects not reporting any cardiovascular (SAPALDIA4).
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45. SPHN - The Swiss Aging Citizen Reference (SACR)
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Jeong, Ayoung, Bochud, Murielle, Cattin, Philippe, Dermitzakis, Manolis, Draganski, Bogdan, Papassotiropoulos, Andreas, Preisig, Martine, Stieltjes, Bram, Vollenweider, Peter, and Probst-Hensch, Nicole
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In Switzerland by 2045, we expect 2.7 Mio citizens aged 65+ of whom 1.0 Mio. aged 80+. A priority and focus of personalized health research is therefore aging biology to extend healthy life expectancy. Novel molecular and imaging features will emerge as candidate targets for risk prediction and screening of chronic diseases. It is of utmost importance to test the clinical and public health utility of candidate biomarkers evolving from this research in citizen reference cohorts. We will build a Swiss Aging Citizen Reference (SACR), a testable and scalable reference cohort offering interoperable, searchable, and accessible data. 1000 participants from existing Swiss citizen cohorts will be combined and analyzed for DNA methylation and MRI brain imaging. SACR will serve as a testbed for clinical and public health utility of candidate biomarkers. As for a proof-of-concept study, we will conduct an agnostic search for structural and functional brain features associated with epigenetic aging acceleration to examine the potential of epigenetic age acceleration as the intermediate aging biomarker and to better understand the aging mechanism in brain.
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- 2020
46. Fawcett_et_al_Extended_data_supplement.docx
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Fawcett, Katherine, Ma'en Obeidat, Melbourne, Carl, Shrine, Nick, Guyatt, Anna, John, Catherine, Jian'an Luan, Richmond, Anne, Moksnes, Marta, Granell, Raquel, Weiss, Stefan, Imboden, Medea, May-Wilson, Sebastian, Hysi, Pirro, Boutin, Thibaud, Portas, Laura, Flexeder, Claudia, Harris, Sarah, Wang, Carol, Leo-Pekka Lyytikäinen, Palviainen, Teemu, Foong, Rachel, Keidel, Dirk, Minelli, Cosetta, Langenberg, Claudia, Yohan Bosse, Berge, Maarten Van Den, Sin, Don, Hao, Ke, Campbell, Archie, Porteous, David, Sandosh Padmanabhan, Smith, Blair, Evans, David, Ring, Sue, Langhammer, Arnulf, Hveem, Kristian, Cristen Willer, Ewert, Ralf, Stubbe, Beate, Pirastu, Nicola, Klaric, Lucija, Joshi, Peter, Patasova, Karina, Mangino, Massimo, Polasek, Ozren, Starr, John, Karrasch, Stefan, Strauch, Konstantin, Meitinger, Thomas, Rudan, Igor, Rantanen, Taina, Pietilainen, Kirsi, Kahonen, Mika, Raitakari, Olli, Hall, Graham, Sly, Peter, Pennell, Craig, Kaprio, Jaakko, Lehtimaki, Terho, Vitart, Veronique, Deary, Ian, Jarvis, Debbie, Wilson, James, Spector, Tim, Probst-Hensch, Nicole, Wareham, Nick, Völzke, Henry, Henderson, John, Strachan, David, Brumpton, Ben, Hayward, Caroline, Hall, Ian, Tobin, Martin, and Wain, Louise
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This document comprises supplementary materials and methods and extended data for the paper entitled: "Variants associated with HHIP expression have sex-differential effects on lung function", which has been submitted to Wellcome Open Research. Main materials and methods and funding can be found in the main manuscript document.
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- 2020
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47. MOESM2 of Effects of school-based physical activity and multi-micronutrient supplementation intervention on growth, health and well-being of schoolchildren in three African countries: the KaziAfya cluster randomised controlled trial protocol with a 2 × 2 factorial design
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Gerber, Markus, Ayekoé, Serge, Beckmann, Johanna, Bassirou Bonfoh, Coulibaly, Jean, Daouda, Dao, Randt, Rosa, Finda, Lina, Gall, Stefanie, Getrud Mollel, Lang, Christin, Long, Kurt, Ludyga, Sebastian, Honorati Masanja, Müller, Ivan, Siphesihle Nqweniso, Fredros Okumu, Probst-Hensch, Nicole, Pühse, Uwe, Steinmann, Peter, Traoré, Sylvain, Walter, Cheryl, and Utzinger, Jürg
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ComputingMilieux_GENERAL ,Data_FILES - Abstract
Additional file 2: Spirit flow chart.
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48. Genome-wide sex interaction study summary statistics for lung function traits in UK Biobank
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Fawcett, Katherine, Ma'en Obeidat, Melbourne, Carl, Shrine, Nick, Guyatt, Anna, John, Catherine, Jian'an Luan, Richmond, Anne, Moksnes, Marta, Granell, Raquel, Weiss, Stefan, Imboden, Medea, May-Wilson, Sebastian, Hysi, Pirro, Boutin, Thibaud, Portas, Laura, Flexeder, Claudia, Harris, Sarah, Wang, Carol, Leo-Pekka Lyytikäinen, Palviainen, Teemu, Foong, Rachel, Keidel, Dirk, Minelli, Cosetta, Langenberg, Claudia, Yohan Bosse, Berge, Maarten Van Den, Sin, Don, Hao, Ke, Campbell, Archie, Porteous, David, Sandosh Padmanabhan, Smith, Blair, Evans, David, Ring, Sue, Langhammer, Arnulf, Hveem, Kristian, Cristen Willer, Ewert, Ralf, Stubbe, Beate, Pirastu, Nicola, Klaric, Lucija, Joshi, Peter, Patasova, Karina, Mangino, Massimo, Polasek, Ozren, Starr, John M, Karrasch, Stefan, Strauch, Konstantin, Meitinger, Thomas, Rudan, Igor, Rantanen, Taina, Pietilainen, Kirsi, Kahonen, Mika, Raitakari, Olli, Hall, Graham, Sly, Peter, Pennell, Craig, Kaprio, Jaakko, Lehtimaki, Terho, Vitart, Veronique, Deary, Ian, Jarvis, Debbie, Wilson, James, Spector, Tim, Probst-Hensch, Nicole, Wareham, Nick, Völzke, Henry, Henderson, John, Strachan, David, Brumpton, Ben, Hayward, Caroline, Hall, Ian, Tobin, Martin, and Wain, Louise
- Abstract
These summary statistics are derived from a genome-wide sex interaction study on spirometry-based lung function traits (forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), the ratio of FEV1 and FVC (FEV1/FVC), and peak expiratory flow (PEF) in UK Biobank. Summary statistics are contained within the following files (one for each outcome). Coordinates are genome build hg19 (GRCh37).FawcettKA_prePMID_FEV1.tsv.gzFawcettKA_prePMID_FEV1_FVC_ratio.tsv.gzFawcettKA_prePMID_FVC.tsv.gzFawcettKA_prePMID_PEF.tsv.gzThe following columns are provided: variant_id, p_value, chromosome, base_pair_location, effect_allele, other_allele, effect_allele_frequency, beta, and standard_errorThis study used anonymised data from UK Biobank (RRID: SCR_012815), which comprises over 500,000 volunteer participants aged 40-69 years recruited across Great Britain between 2006 and 2010. The protocol and consent were approved by the UK Biobank’s Research Ethics Committee. Our analysis was conducted under approved UK Biobank data application number 648. Individuals were included in this study if (i) they had no missing data for sex, age, height, and smoking status, (ii) their spirometry data passed quality control, as described previously (Shrine et al. Nat Genet. 2019;51(3):481-93. Epub 2019/02/26. doi: 10.1038/s41588-018-0321-7. PubMed PMID: 30804560; PubMed Central PMCID: PMCPMC6397078), (iii) their genetically inferred sex matched their reported sex, (iv) they had genome-wide imputed genetic data, (v) they were of genetically determined European ancestry, and (vi) they were not first- or second-degree relatives of any other individual included in the study. In total, 303,612 individuals met these criteria.Participants' DNA was genotyped using either the Affymetrix Axiom(r) UK BiLEVE array or the Affymetrix Axiom(r) UK Biobank array (Bycroft et al., Nature. 2018 Oct;562(7726):203-209). Genotypes were imputed based on the Human Reference Consortium (HRC panel, as described elsewhere (Bycroft et al.). Variants with minor allele frequency (MAF)Spirometry-based lung function traits FEV1, FEV1/FVC, FVC, and PEF were pre-adjusted for age, age-squared, standing height and smoking status and the residuals rank-transformed to normality using the rntransform function of the GenABEL package (RRID: SCR_001842) in R (RRID: SCR_001905). To test each imputed autosomal variant for an interaction effect, a linear regression model with genotype (additive effect), sex, genotype-by-sex interaction, genotyping array and the first ten ancestry-based principal components included as covariates was implemented using Plink 2.0 software (RRID: SCR_001757) (https://www.cog-genomics.org/plink/2.0/).For further details see the manuscript: Variants associated with HHIP expression have sex-differential effects on lung function. Wellcome Open Research.
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- 2020
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49. MOESM1 of Effects of school-based physical activity and multi-micronutrient supplementation intervention on growth, health and well-being of schoolchildren in three African countries: the KaziAfya cluster randomised controlled trial protocol with a 2 × 2 factorial design
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Gerber, Markus, Ayekoé, Serge, Beckmann, Johanna, Bassirou Bonfoh, Coulibaly, Jean, Daouda, Dao, Randt, Rosa, Finda, Lina, Gall, Stefanie, Getrud Mollel, Lang, Christin, Long, Kurt, Ludyga, Sebastian, Honorati Masanja, Müller, Ivan, Siphesihle Nqweniso, Fredros Okumu, Probst-Hensch, Nicole, Pühse, Uwe, Steinmann, Peter, Traoré, Sylvain, Walter, Cheryl, and Utzinger, Jürg
- Abstract
Additional file 1: Hypotheses associated with each of the study’s outcomes.
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- 2020
- Full Text
- View/download PDF
50. The mediating effect of immune markers on the association between ambient air pollution and adult-onset asthma
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Mostafavi, Nahid, Jeong, Ayoung, Vlaanderen, Jelle, Imboden, Medea, Vineis, Paolo, Jarvis, Debbie, Kogevinas, Manolis, Probst-Hensch, Nicole, Vermeulen, Roel, One Health Chemisch, dIRAS RA-2, Commission of the European Communities, One Health Chemisch, and dIRAS RA-2
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0301 basic medicine ,Male ,lcsh:Medicine ,Disease ,Overweight ,DISEASE ,0302 clinical medicine ,11. Sustainability ,Odds Ratio ,POLLUTANTS ,OXIDATIVE STRESS ,Age of Onset ,lcsh:Science ,Multidisciplinary ,Confounding ,Chronic inflammation ,Middle Aged ,3. Good health ,Multidisciplinary Sciences ,LUNG-FUNCTION ,SWISS ,Cohort ,Science & Technology - Other Topics ,Female ,medicine.symptom ,Adult ,Mediation (statistics) ,Inflammation ,ESCAPE ,Models, Biological ,Article ,03 medical and health sciences ,Immune system ,INFLAMMATION ,Air Pollution ,medicine ,Confidence Intervals ,Humans ,COHORT ,EXPOSURE ,Least-Squares Analysis ,General ,Asthma ,Aged ,Science & Technology ,business.industry ,lcsh:R ,Diagnostic markers ,medicine.disease ,030104 developmental biology ,Logistic Models ,13. Climate action ,Immunology ,lcsh:Q ,business ,030217 neurology & neurosurgery ,Biomarkers - Abstract
We aim to investigate to what extent a set of immune markers mediate the association between air pollution and adult-onset asthma. We considered long-term exposure to multiple air pollution markers and a panel of 13 immune markers in peripheral blood samples collected from 140 adult cases and 199 controls using a nested-case control design. We tested associations between air pollutants and immune markers and adult-onset asthma using mixed-effects (logistic) regression models, adjusted for confounding variables. In order to evaluate a possible mediating effect of the full set of immune markers, we modelled the relationship between asthma and air pollution with a partial least square path model. We observed a strong positive association of IL-1RA [OR 1.37; 95% CI (1.09, 1.73)] with adult-onset asthma. Univariate models did not yield any association between air pollution and immune markers. However, mediation analyses indicated that 15% of the effect of air pollution on risk of adult-onset asthma was mediated through the immune system when considering all immune markers as a latent variable (path coefficient (β) = 0.09; 95% CI: (−0.02, 0.20)). This effect appeared to be stronger for allergic asthma (22%; β = 0.12; 95% CI: (−0.03, 0.27)) and overweight subjects (27%; β = 0.19; 95% CI: (−0.004, 0.38)). Our results provides supportive evidence for a mediating effect of the immune system in the association between air pollution and adult-onset asthma.
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- 2019
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