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Aim: To investigate Prussian blue nanoparticles (PBNPs) coated with the synthetic analog of dsRNA polyinosinic-polycytidylic acid (polyIC) for their ability to function as HIV latency reversing agents. Methods: A layer-by-layer method was used to synthesize polyIC-coated PBNPs (polyIC-PBNPs). PolyIC-PBNPs were stable and monodisperse, maintained the native absorbance properties of both polyIC and PBNPs and were obtained with high nanoparticle collection yield and polyIC attachment efficiencies. Results: PolyIC-PBNPs were more effective in reactivating latent HIV than free polyIC in a cell model of HIV latency. Furthermore, polyIC-PBNPs were more effective in promoting immune activation than free polyIC in CD4 and CD8 T cells. Conclusion: PBNPs function as efficient carriers of nucleic acids to directly reverse HIV latency and enhance immune activation.

This project aims to find fake logos by matching and detecting them against the original logo. This is accomplished by dividing the logo picture into rows and columns and assigning an index value to each cell. The values in each cell are referred as pixels which can be compared with logo image to classify whether it’s a fake logo or original logo. To say whether the logo is fake or the original by looking at the relationship between the pixel values of both the original and the logo in training dataset. The original logo is determined by the pixel values of all cells exactly matching the genuine logo otherwise its fake logo. The convolution neural network algorithm is used for detecting and classifying the logo.

The biogenic synthesis of silver nanoparticles (AgNPs) has attracted many researchers due to their physical, chemical, optical, and biological properties, embracing range of activities such as antibacterial, antifungal, anti-inflammatory, and anti-cancer activities. The purpose of this work is to synthesize and characterize AgNPs using Argyreia Nervosa (AN) plant leaf extract as well as to test their antimicrobial applications. In this work, silver nitrate (AgNO3) at 0.1mM concentration, and stable AgNPs were synthesized and observed by monitoring the colour change of the solution from light yellow to brown. The UV-Vis spectrum shows a peak at 445nm, confirming the formation of AN-AgNPs and Fourier-transformed infrared (FTIR) results confirm the presence of chemical groups which act as reducing agents stabilizing the AN-AgNPs and antimicrobial capping agents enhancing antimicrobial properties of AN-AgNPs. The crystalline behaviour of these AN-AgNPs confirms through X-Ray Diffraction (XRD) peaks. The morphology of AN-AgNPs and their size shows different sizes, ranging from 10 to 40nm using Scanning Electron Microscopy (SEM). The disk diffusion assay shows the antimicrobial activity over E-Coli pathogenic microorganisms of clinical interest. The obtained results confirm a more significant antimicrobial effect of the biogenic AN-AgNPs maintaining low cytotoxicity. This work presents a potential way to produce non-toxic biogenic AgNPs with enhanced antibacterial activity, which can meet the increasing global demand for biogenic AgNPs as an alternative to antibiotics.

Obesity is a well-known risk factor for many diseases. It is also known to enhance complications of many diseases eg. Type 2 Diabetes mellitus (T2DM). This study was done to assess the gustatory functions in obese T2DM individuals. This study was done to assess the gustatory functions in obese T2DM subjects and compare the same with lean T2DM individuals. A comparative study with a sample size of 40 was conducted. Patients aged 25 to 50 years with T2DM < 5 years duration and HBA1C ≤ 7 were divided into 2 groups, Group I- with normal weight (BMI of 18.5 to Taste scores for sweet, salty, sour, and bitter tastants were lesser in obese diabetics as compared to the lean T2DM subjects. This was statistically significant (p < 0.05) Conclusion: Taste impairment is observed in obese diabetic subjects. This could be an indication of early central diabetic neuropathy. Hypogeusia may cause an increased preference for sweet-tasting or salty foods thus imposing greater health risks, increasing obesity, and negatively affecting the quality of life.

Cloud is the on-demand availability for data storage management in large-scale companies and even for government sites where the data should be highly confidential. Here, data security plays an equivalent role to data storage. Cloud security is a collection of security measures that are designed to protect cloud-based infrastructure, data, and applications. The level of cloud security differs based on the type of cloud services. Cloud security protects the cloud environment from several attacks like distributed denial of attack, and malware, and prevents unauthorized user access. A crucial component of cloud security in large-scale organizations and for the government is focused on protecting the business contents like customer details, secret design documents, financial records, etc. Keywords: MD5, SHA12, padding bits, buffers, salt hashes, keyed hashes, adaptive hashes.

Sanitarium wastes pose significant public health hazard if not duly managed. Hence, it's necessary to develop and borrow optimal waste management systems in the hospitals. Bio-medical waste (BMW) generated in our nation on a day-to-day base is immense and contains contagious and dangerous accoutrements. With the rise in COVID-19 cases, there are concerns about the disposal of huge amounts of biomedical waste. Tamil Nadu generated 35269.74 kg/per day of COVID-19 ‘bio-medical waste’ between 2020 to 2021. This paper deals on managing the Bio-medical waste (BMW) using Incineration and Autoclaving. Keywords: Bio-medical waste (BMW), World Health Organization (WHO), Tamil Nadu Pollution Control Board (TNPCB), common bio-medical waste treatment and disposal facility (CBMWTF), Incineration, Autoclaving

Economic-emission load dispatch minimizes fuel cost factors and gas emissions to provide optimal performance in generation units in a power plant, ensuring demand supply. The first variable is definitive to maintain business continuity, and the second to assure compliance with environmental legislation and no environmental harm. This work investigates the application of a new computational optimization technique known as the Search and Rescue Optimization Algorithm (SAR), which improves searching capability by employing specified parameters. This algorithm has three effective parameters and works with all generators to minimize the cost and emission while satisfying the defined demand. Simulations were run on multiple IEEE test systems with varying demand values. The obtained findings were compared to each other as well as to the results of other procedures mentioned in the literature. The acquired results appear to be superior to those achieved by other metaheuristics algorithms.

Simply turn on your carpus then your hand becomes your mobile. It has capable of showing a touch screen display on your carpus, it facilitates the process you to have easy access and works your applications without carrying your mobile phones. The Virtual Wearable Bands shows your phone's display onto your carpus by using a Pico projector with the help of eight Proximity Sensors. These sensors allow the bracelet to identify your finger location based on the proximity sensor. In this project, the connection between the mobile app and virtual band using ZigBee. The ZigBee is the foremost technology it works in low power, low cost, and efficient network. This is IoT based project with the help of a Proximity sensor, pico-projector. Moreover, we develop a new app to interconnect bands and our own phones. we call this app as a virtual app. It is used for browsing the website, hearing music, chatting and talking with your friends and colleagues, receiving the mail at any instance, playing games, watching videos without carrying any phone with help of a Virtual Band.

To study the prevalence, types and demographic profile of traditional eye medicine (TEM) use among corneal ulcer patients presenting to a tertiary eye care centre in South India.A cross-sectional study conducted on 432 new corneal ulcer patients at a tertiary eye care centre in South India from September 2018 to July 2019. Data collected included demographic profile such as name, age, sex, occupation, income, rural/urban residence, type of TEM use. Of the 432 new corneal ulcer cases, 32 used TEM. Most TEM users belonged to the age group 40- 60 years (n= 20; 62.5%). There was no difference in sex distribution. Majority of TEM users in our study resided in rural areas (n= 30; 93.75%), were involved in agriculture as occupation (n=28, 87.5%) and belonged to the lower socioeconomic status n=31(96.88%) as per Kuppuswamy classification. Profile of TEM used ranged from plant extract (n= 14; 43.75%), tongue cleaning (n= 5; 15.63%), oil (n= 7; 21.87%), breast milk (n= 4; 12.5%) and ash (n= 2; 6.25%). Use of traditional medicine is a prevalent practice in the study population. These findings offer a better understanding of health seeking behaviour of the study population which will lead to better planning, implementation and targeting of preventive and promotive eye services and awareness programmes.

Prussian blue nanoparticles (PBNPs) are effective photothermal therapy (PTT) agents: they absorb near-infrared radiation and reemit it as heat via phonon-phonon relaxations that, in the presence of tumors, can induce thermal and immunogenic cell death. However, in the context of central nervous system (CNS) tumors, the off-target effects of PTT have the potential to result in injury to healthy CNS tissue. Motivated by this need for targeted PTT agents for CNS tumors, we present a PBNP formulation that targets fibroblast growth factor-inducible 14 (Fn14)-expressing glioblastoma cell lines. We conjugated an antibody targeting Fn14, a receptor abundantly expressed on many glioblastomas but near absent on healthy CNS tissue, to PBNPs (aFn14-PBNPs). We measured the attachment efficiency of aFn14 onto PBNPs, the size and stability of aFn14-PBNPs, and the ability of aFn14-PBNPs to induce thermal and immunogenic cell death and target and treat glioblastoma tumor cells in vitro. aFn14 remained stably conjugated to the PBNPs for at least 21 days. Further, PTT with aFn14-PBNPs induced thermal and immunogenic cell death in glioblastoma tumor cells. However, in a targeted treatment assay, PTT was only effective in killing glioblastoma tumor cells when using aFn14-PBNPs, not when using PBNPs alone. Our methodology is novel in its targeting moiety, tumor application, and combination with PTT. To the best of our knowledge, PBNPs have not been investigated as a targeted PTT agent in glioblastoma via conjugation to aFn14. Our results demonstrate a novel and effective method for delivering targeted PTT to aFn14-expressing tumor cells via aFn14 conjugation to PBNPs.

Actinidia chinensis (kiwi fruit), also known as golden fruit, has its origin in China. All the plant parts of Actinidia chinensis such as fruit, leaves, vine, and root were used in food products and also used as medicine in China. The Worldwide distribution of the kiwi (Actinidia chinensis) is due to its Nutritional property, economic value and the presence of the various phytoconstituents such as terpenoids, quinones, flavones, phenyl proteinoids and steroids. It is also rich in antioxidant and dietary fibres which are utilized for the production of cellulose and hemicellulose. The Nutritional composition of the Kiwi fruit has distinguishing amount of vitamin C and also several other compounds such as Minerals, Vitamin E and Carotenoids and these are used to protect DNA. It has a high amount of medicinal and Nutritional value and also provides various health benefits. In traditional medicine of China, Kiwi fruit is also used in the treatment of Edema, Pyorrhea, gingivitis, Hepatitis, maintenance of blood glucose level, asthma, fight against muscular degenerative diseases and reduces the risk of blood clots and also used in Cancer treatment. Recently researchers have updated that Kiwi fruit has beneficial Physiological effect on the human body through clinical studies. It has been proven that Kiwi has Anti-Oxidant property and relieves Oxidative stress which was the Major cause of Diseases. This article is an overview of kiwi fruit, its nutritional benefits and its antioxidant effect.

Novel corona virus infection or COVID-19 saw its dawn in first fortnight of Decemberin the city of Wuhan, China, since then it is unstoppable and has spread like a wild-fire, involving most parts of the world. The causative virus is named as SARS-CoV-2. Although the reproductive number (R0) of two to three has been suggested, it is still unknown. The symptoms of COVID-19 infection have a broad spectrum of severity, which ranges from asymptomatic to mildly symptomatic to severe illness that require mechanical ventilation. The virus seldom causes any viral exanthem, but dermatologists should have good working knowledge about COVID-19 and its manifestations, which would help to explore the unexplored cutaneous manifestation of the disease in near future. Due to limited availability of testing kits, RT-PCR test is done only in patients who have a clinical diagnosis of COVID-19 based on symptoms, exposures and chest imaging. Basic public health measures like frequent efficient handwashing, social distancing, staying home, respiratory etiquette like covering nose and mouth while coughing and sneezing are to be followed to prevent the spread of disease. It is now time for our specialty to get involved actively and share the burden of COVID-19. Though not directly connected in dealing with COVID-19 patients, dermatologists should work together with other specialties as a multidisciplinary team. We carried out a PubMed, Medline search using the following terms “COVID-19, dermatology, rash, skin, health care” and have included all data and latest national guidelines related to COVID-19 in dermatology.

A dentigerous cyst is an asymptomatic lesion of odontogenic origin mostly involving the mandible. It is associated with the crown of unerupted, partially erupted, or impacted teeth with a higher incidence occurring in males. It is discovered during routine radiographic examinations unless manifests clinically as a large lesion. Radiographically, a dentigerous cyst presents as a radiolucent lesion enveloping the crown of the involved tooth. Enucleation and marsupialization are the surgical modalities. Here we report a case of dentigerous cyst involving mandibular right transmigrated canine. &nbsp

Longitudinal multimodal imaging presents unique opportunities for noninvasive surveillance and prediction of treatment response to cancer immunotherapy. In this work we first designed a novel granzyme B activated self-assembly small molecule, G-SNAT, for the assessment of cytotoxic T lymphocyte mediated cancer cell killing. G-SNAT was found to specifically detect the activity of granzyme B within the cytotoxic granules of activated T cells and engaged cancer cells

Longitudinal multimodal imaging presents unique opportunities for noninvasive surveillance and prediction of treatment response to cancer immunotherapy. In this work we first designed a novel granzyme B activated self-assembly small molecule, G-SNAT, for quantitative assessment of cytotoxic T lymphocyte mediated cancer cell killingin vivo. In lymphoma tumor bearing mice, the retention of cyanine 5 labeled G-SNAT-Cy5 was shown to be highly correlated to CAR T-cell mediated granzyme B release and tumor eradication. In colorectal tumor-bearing transgenic mice, expressing firefly luciferase in hematopoietic cells, and which received combination treatment of anti-PD-1 and anti-CTLA-4, longitudinal bioluminescence and fluorescence imaging revealed the dynamics of immune cell expansion, trafficking, tumor infiltration, and cytotoxic activity which predicted therapeutic outcome before tumor shrinkage was evident. These results support further development of G-SNAT for imaging early immune response to checkpoint blockade and CAR T-cell therapy in patients and highlight the utility of multimodality imaging for improved mechanistic insights into cancer immunotherapy.

The initiation of the Indian summer monsoon circulation during late May / early June arises through large-scale land-sea thermal contrast and setting up of negative pressure gradient between the Monsoon Trough over the Indo-Gangetic plains and the Mascarene High over the subtropical Indian Ocean. The meridional pressure gradient together with the Earth's rotation (Coriolis force) creates the summer monsoon cross-equatorial flow, while feedbacks between moisture-laden winds and latent heat release from precipitating systems maintain the monsoon circulation during the June-September (JJAS) rainy season (Krishnamurti and Surgi, 1987). This simplified view of the Indian monsoon is a useful starting point to draw insights into the variability of the large-scale monsoon circulation., "for associated pdf file, see https://iioe-2.incois.gov.in/documents/IIOE-2/Publications/IIOE-2-DOC_OM_70.pdf]"

One of the commonly occurring diseases across the world is heart disease. About 60 percent of the total population gets affected by the heart disease. Among the several kinds of heart disease, coronary heart disease is dealt in this paper. The healthcare trade gathers enormous amounts of healthcare files which, regrettably, are not mined to determine hidden information for efficient assessment creation. Since enormous sum of people get exaggerated by heart disease, the patients' case history raise to a maximum extent in hospitals, as the result analyzing becomes a difficult process for medical practitioners. In this paper, an effective method to extract the data from the large amount of documents is proposed using text mining. Using text mining techniques, the required data are extracted in the structured format. This paper uses an apriori algorithm in association rule mining, which is used for frequent item set extraction and rule generation. As the result, several rules will be generated from which the disease can be predicted. Meena Preethi. B | Darshna. R | Sruthi. R "Prediction of Coronary Artery Disease Using Text Mining" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-2 | Issue-6 , October 2018, URL: https://www.ijtsrd.com/papers/ijtsrd18401.pdf

Microbulbifer strain CMC-5, isolated from decomposing seaweeds degrades agar, alginate, carrageenan, chitin, carboxymethyl cellulose and xylan. Using bacterial strain CMC-5 as host, a novel virulent phage, designated ϕMC1 was isolated from the coast of Goa, India. Although ϕMC1 demonstrated cross infectivity with type species of Microbulbifer such as M. agarolyticus JAMBA3T and M. celer KCTC 12973T, it did not infect M. mangrovi KCTC 23483T, M. salipalidus JCM 11542T, M. elongatus DSM 6810T and M. hydrolyticus IRE-31T. The one step growth experiment of ϕMC1 infecting bacterial strain CMC-5 at a multiplicity of infection of 0.1, revealed a latent period of 60 min and a burst size of 180. TEM analysis of ϕMC1 indicated it to be a tailless phage with an icosahedral head having a diameter of 60 ± 1.42 nm. The ds DNA of ϕMC1 was restricted by EcoRI, HindIII and SmaI whereas HaeIII, BamHI, PstI, NotI did not cleave the DNA. The molecular size of ϕMC1 DNA was analyzed by restriction digestion as well as pulsed field gel electrophoresis and was estimated at 48.5 kb. The phage infectivity was adversely affected by organic solvents demonstrating the presence of a lipid membrane. The inhibition of ϕMC1 infectivity by EDTA was abolished by addition of Ca and Mg salts.

Highlights • Microbulbifer strain CMC-5 produces multiple carbohydrases. • Expression of carbohydrases was investigated in presence of homologous/heterologous polysaccharides. • Gracilaria corticata biomass induces agarases production in Microbulbifer strain CMC-5. • Microbulbifer strain CMC-5 was exploited to produce single cell detritus from Gracilaria corticata., Microbulbifer strain CMC-5 produces agarase, alginate lyase, xylanase, carboxymethyl cellulase and carrageenase. The extracellular production of the above carbohydrases was investigated by growing Microbulbifer strain CMC-5 in a sea water based medium containing homologous/heterologous polysaccharides as a single substrate or as a combination of mixed assorted substrate. Presence of singular homologous polysaccharides in the growth medium induces respective carbohydrase at high levels. Any two polysaccharides in various combinations produced high level of homologous carbohydrase and low level of other heterologous carbohydrase. All five carbohydrases were consistently produced by strain CMC-5, when carboxymethyl cellulose was included as one of the substrate in dual substrate combination, or in presence of mix blends of all five polysaccharides. Interestingly, thalli of Gracilaria sp. that contain agar and cellulose predominantly in their cell wall induces only agarase expression in strain CMC-5.

Lectins are the glycoproteins known to bind specifically to carbohydrates on the cell surface. Microorganisms such as bacteria, fungi, protozoa, and viruses produce lectins that in turn provide the microbes with several advantages such as adhesion, infection, and inhibition of other microbes. Microbial lectins are unique in properties, which make them a valuable tool in various fields of biology such as immunology, oncology, and biochemistry. Microbial lectins are also responsible for several important bioprocesses such as bioremediation and bioflocculation. Lectin-mediated aggregation in microorganisms is responsible for bioflocculation of activated sludge as well as bioremediation of heavy metals. This chapter focuses on lectins from different microorganisms and the roles they exhibit, along with the mechanism of action. Different applications of microbial lectins exploited in diverse areas of biology have also been covered, with highlights of some practical approaches and research pertaining to microbial lectins.

COVID-19 since the dawn has changed the way we look at things around us. Medical practice has changed drastically, so is dermatology practice. Clinical and procedural dermatology practice had come to a standstill in India, due to the past COVID-19 situations. With the changing scenario, now it is time for dermatologists as well as dermatology field to sail through these difficult times, with extra care and precautions. According to the latest CDC and ICMR guidelines, we have designed the following proposed guidelines from entrance to exit for the smooth functioning of dermatology institute/hospital/clinic. Potential setbacks related to patient and manpower, their management during COVID-19 pandemic has been reviewed. Potential setbacks related to clinical dermatology practice and procedures, their management during COVID-19 pandemic has been reviewed and briefed. Hard times are usually blessings in disguise; hence, we should utilize this pandemic period to learn and rejuvenate our practice.

A 47-year-old female patient presented with painless skin colored and erythematous papules coalesced to form plaques over lower abdomen for 10 days. She had undergone exploratory laparotomy with hysterectomy and bilateral oophorectomy 1 month ago, and histopathology was reported as Krukenbergs tumor. She was getting evaluated for primary, when she was referred to dermatology. A clinical diagnosis of cutaneous infiltration of tumor was made, and biopsy was done from a representative lesion which showed features suggestive of metastatic poorly differentiated adenocarcinoma. In the majority of cases in the past, cutaneous metastasis is seen much later in the course of the disease. High degree of suspicion and histopathology was helpful in the diagnosis of underlying malignancy in our patient.

Context: Psoriasis is a chronic, systemic disease with the beneficial effect of topical vitamin D3 analogs, known for a long time. Low levels of vitamin D are increasingly found to be associated with the initial development of some autoimmune diseases. There are contradictory reports of low serum levels of vitamin D3 in the pathogenesis of psoriasis. Aims: (1) To determine the serum levels of vitamin D, calcium and C-reactive protein (CRP) in patients with psoriasis vulgaris, (2) To compare these levels with the serum levels of controls, and (3) To correlate them with the severity of the disease. Subjects and Methods: A hospital-based case–control study with 61 patients of psoriasis and 61 age- and sex-matched controls was undertaken. A detailed history was taken and examination including body mass index, Psoriasis Area and Severity Index (PASI) was done. Estimations of serum vitamin D, serum calcium, and CRP levels were done. Results: Mean 25(OH) vitamin D level was not significantly different between persons with and without psoriasis. Mean vitamin D level in cases was 18.41±9.41 and that in controls was 17.24±13.03 (P=0.63). However, vitamin D level were significantly lower in females than in males in both cases (P=0.02) and controls (P=0.006). There was no significant correlation between the severity of psoriasis and serum levels of vitamin D, serum calcium, and CRP. Conclusions: Serum level of vitamin D did not correlate with the severity of psoriasis in our study.

Background and Aims: Accurate prediction of the Cormack-Lehane (CL) grade preoperatively can help in better airway management of the patient during induction of anaesthesia. Our aim was to determine the utility of ultrasonography in predicting CL grade. Methods: We studied 100 patients undergoing general endotracheal anaesthesia. Mallampati (MP) class, thyromental distance (TMD) and sternomental distance (SMD) were noted. Ultrasound measurements of the anterior neck soft tissue thickness at the level of the hyoid (ANS-Hyoid), anterior neck soft tissue thickness at the level of the vocal cords (ANS-VC) and ratio of the depth of the pre-epiglottic space (Pre-E) to the distance from the epiglottis to the mid-point of the distance between the vocal cords (E-VC) were obtained. CL grade was noted during intubation. Chi-square test was employed to determine if there was any statistical difference in the measurements of patients with different CL grades. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy were calculated for the various parameters. Results: The incidence of difficult intubation was 14%. An ANS-VC >0.23 cm had a sensitivity of 85.7% in predicting a CL Grade of 3 or 4, which was higher than that of MP class, TMD and SMD. However, the specificity, PPV and accuracy were lower than the physical parameters. The NPV was comparable. Conclusion: Ultrasound is a useful tool in airway assessment. ANS-VC >0.23 cm is a potential predictor of difficult intubation. ANS-Hyoid is not indicative of difficult intubation. The ratio Pre-E/E-VC has a low to moderate predictive value.

Complex polysaccharides (CPs) such as agar, alginates, carrageenan, etc., are largely present as component of cell wall of seaweeds, promoting structural integrity and shielding the host from pathogens or predators. Marine bacteria-degrading CPs are ubiquitous and have been isolated from diverse sources such as costal water, sediments, and deep sea, as well as from the surface of seaweeds and crustaceans. Polysaccharide-degrading enzymes (carbohydrases) such as agarase, alginate lyase, and carrageenase are produced by CP-degrading bacteria that aid in depolymerizing agar, alginate, and carrageenan, respectively. The resultant oligosaccharides are subsequently degraded to various intermediates that are further channelized to energy conversion pathways. Several of these carbohydrases have been purified, and study of their biochemical properties such as molecular weight, substrate specificity, pH, and temperature range for optimal activity indicates a vast diversity. Recently, several multiple CP-degrading bacteria (epiphytic/free form) have been isolated. Saccharophagus degradans and Microbulbifer species are the dominant groups of multiple polysaccharide-degrading bacteria and play a significant role in recycling of carbon from CPs. In natural marine ecosystem, the cell wall of seaweeds comprises an array of CPs in mixed proportion. The production of diverse carbohydrases by CP-degrading bacteria enables it to decompose seaweeds into single cell detritus as well as generate reducing sugars from degraded polysaccharides. Thus, CP-degrading bacteria are potential candidates for eco-friendly degradation of algal waste.

Background: Psoriasis is a common, chronic inflammatory disorder of skin characterized by a long clinical course with exacerbations, remissions, and relapses. The cost of therapy and psychological burden of the disease depends on disease severity. The objective of this study was to assess the quality of life and financial status and to correlate the financial burden of the disease with the severity of psoriasis and quality of life. Materials and Methods: A total of 102 psoriasis patients attending the dermatology outpatient department in our hospital were enrolled in this study. A detailed history and complete physical examination, including, Psoriasis Area and Severity Index (PASI), was done. Their family income was calculated. Quality of life was measured using the dermatology life quality index (DLQI) proposed by Finlay et al. Multiple linear regression was done to identify the predictor variables of quality of life (DLQI). P < 0.05 was considered statistically significant. Results: Among the 102 psoriasis patients 78 were men(76.5%) and 24 were women(23.5%). The mean PASI score was 8.20 ± 6.18 the mean DLQI was 13.01 ± 6.95, and mean family income was INR 15570.10 ± INR 10081.82 per month. There was a significant positive correlation between disease severity and DLQI, and a significant negative correlation between family income and PASI as well as DLQI. Conclusion: The quality of life in psoriasis is affected by both the disease severity and financial status of the patient. The chronic course of psoriasis along with disease severity, in a background of low financial status, impairs the quality of life.

Alzheimer’s disease (AD) is a neurodegenerative disorder that starts slowly, progressively leads to death and contributes to about 60-70% cases of dementia. AD is characterized with Senile Plaques (SPs) and neurofibrillary tangles (NFTs) and the major symptoms include problems with language, dis-orientation of words, unable to manage self-care, memory loss and behavioural issues which gradually lead to completely lose bodily functions later. The actual cause for the disease is not known till date. Recent research show distinct paths that closely try to reveal various cytoplasmic, genetic, behavioural, environmental and epigenetic causes that may lead to the development of AD. Most likely all studies target the Senile Plaques, protein fragments called beta-amyloid and Neurofibrillary Tangles, twisted fibres of a protein called tau. Since, the exact causative mechanism is not yet clearly understood, ultimately finding a suitable treatment or management for the disease has also become an ominous challenge for researchers.Keywords: Alzheimer’s disease, Pathology, Phosphatase and tensin, Senile plaques, Neurofibrillary tangles

The present study examines the mean features of Indian summer monsoon and the boreal summer intra-seasonal oscillations (BSISO) as simulated by the Weather Research and Forecasting (WRF) regional atmospheric model. For this the WRF model at 30-km horizontal resolution is forced with NCEP-II reanalysis as the initial and boundary condition and integrated for a period of 8 years. The simulated results are compared with TRMM rainfall as well as with the reanalysis datasets of NCEP-II and ERA-Interim. Analysis reveals that the WRF model is able to reproduce the observed characteristics of large scale mean features and spatial variations of rainfall and winds at 850hPa and 200hPa. The northward propagating intra-seasonal oscillation (ISO) components over the monsoon trough and the equatorial Indian Ocean is reasonably simulated by the WRF model and shows some promise in understanding the regional characteristics of Indian summer monsoon and its ISO components. WRF model can act as suitable tool for predicting the ISO's over the Indian summer monsoon region. Further, the results presented here suggests that reanalysis with a realistic basic state and proper representation of northward moving ISO's is required to force a regional model. This study elucidate the WRF regional model has shown a reasonable representation of BSISO.

The longevity of fixed partial denture depends on the type of luting cement used with tooth preparation. The clinician's understating of various cements, their advantages and disadvantages is of utmost importance. In recent years, many luting agents cements have been introduced claiming clinically better performance than existing materials due to improved characteristics. Both conventional and contemporary dental luting cements are discussed here. The various agents discussed are: Zinc phosphate, Zinc polycarboxylate, Zinc oxide-eugenol, Glass-ionomer, Resin modified GIC, Compomers and Resin cement. The purpose of this article is to provide a discussion that provides a clinical perspective of luting cements currently available to help the general practitioner make smarter and appropriate choices. How to cite the article: Lad PP, Kamath M, Tarale K, Kusugal PB. Practical clinical considerations of luting cements: A review. J Int Oral Health 2014;6(1):116-20.

Diffuse large B-cell lymphoma (DLBCL) is a subtype of non-Hodgkin's lymphoma (NHL) making up about approximately 30% of all NHL. Its occurrence in the mandible is very rare. Histopathologically, five variants of DLBCL have been recognized among which centroblastic variant is the one with better prognosis. We report a case of a 55 year-old patient who presented with a painless swelling in the lower right body of the mandible since 4 months. Incisional biopsy revealed NHL like features, confirmed by immunohistochemistry using CD45, CD20, and CD3 markers to be a DLBCL of centroblastic variant. Patient was treated with chemotherapy following which the lesion regressed completely with no further recurrences. Precise histological diagnosis is crucial for the clinical management and ultimately for the survival of the patient.

Cancer stem cells (CSCs) are the tumor cell subpopulation responsible for resistance to chemotherapy, tumor recurrence, and metastasis. An efficient therapy must act on low proliferating quiescent-CSCs (q-CSCs). We here investigate the effect of magnetic hyperthermia (MHT) in combination with local chemotherapy as a dual therapy to inhibit patient-derived colorectal qCR-CSCs. We apply iron oxide nanocubes as MHT heat mediators, coated with a thermoresponsive polymer (TR-Cubes) and loaded with DOXO (TR-DOXO) as a chemotherapeutic agent. The thermoresponsive polymer releases DOXO only at a temperature above 44 °C. In colony-forming assays, the cells exposed to TR-Cubes with MHT reveal that qCR-CSCs struggle to survive the heat damage and, with a due delay, restart the division of dormant cells. The eradication of qCR-CSCs with a complete stop of the colony formation was achieved only with TR-DOXO when exposed to MHT. The in vivo tumor formation study confirms the combined effects of MHT with heat-mediated drug release: only the group of animals that received the CR-CSCs pretreated, in vitro, with TR-DOXO and MHT lacked the formation of tumor even after several months. For DOXO-resistant CR-CSCs cells, the same results were shown, in vitro, when choosing the drug oxaliplatin rather than DOXO and applying MHT. These findings emphasize the potential of our nanoplatforms as an effective patient-personalized cancer treatment against qCR-CSCs.