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56 results on '"Prandi, Cristina"'

1. Strigolactones as Broad-Spectrum Antivirals against β-Coronaviruses through Targeting the Main Protease Mpro

Author

Biolatti, Matteo, Blangetti, Marco, Melissa, Baggieri, Antonella, Marchi, Silvia, Gioacchini, Bajetto, Greta, Arnodo, Davide, Paola, Bucci, Raoul, Fioravanti, Maedeh, Kojouri, Bersani, Matteo, D'Arrigo, Giulia, Lydia, Siragusa, Ghinato, Simone, DE ANDREA, Marco, Gugliesi, Francesca, Albano, Camilla, Pasquero, Selina, Visentin, Ivan, Emilio, D’Ugo, Francesca, Esposito, Paolo, Malune, Enzo, Tramontano, Prandi, Cristina, Spyrakis, Francesca, Fabio, Magurano, and Dell'Oste, Valentina

Subjects
HCoV-OC43, antiviral screening, strigolactones, HCoV-OC43, SARS-CoV-2, Mpro, SARS-CoV-2, antiviral screening, strigolactones, Mpro
Published
2023

4. Strigolactones - Biology and Applications

Author

Prandi, Cristina

Subjects
plant physiology, plant hormones, plant hormones, agriculture, plant physiology, organic chemistry, agriculture, organic chemistry
Published
2019

5. From synthetic control to natural products: a focus on N-heterocycles

Author

Prandi, Cristina and Occhiato, Ernesto G

Subjects
Biological Products, alkaloids, bioactivity, natural compounds, piperidine, Agronomy and Crop Science, Insect Science, Heterocyclic Compounds
Abstract

Natural products containing a N-heterocycle motif are widespread in nature and medicinal plants, in particular, have proved to be a source of almost unlimited N-derived structures with high molecular diversity. Because of their intrinsic potential for use in both biomedical and agricultural applications, there is a general need for new compounds and for the synthesis of 'natural-inspired' analogues. Importantly, transition of a natural product from discovery to a 'market lead' is associated with an increasingly challenging demand for more of the compound, which cannot be met by isolation from natural plant sources, often due to low extraction yields and uneven availability of the plant source itself. Synthesis remains the most reliable approach to provide valuable products for the market. In this review, a comprehensive overview of our contribution to synthetic access to N-derived natural products is given. Major strengths of the proposed methodologies are discussed critically. © 2019 Society of Chemical Industry.

Published
2018

14. Synthesis of vinylogous amides by gold(I)-catalyzed cyclization of N-Boc-protected 6-alkynyl-3,4-dihydro-2H-pyridines

Author

Alberto, Oppedisano, Prandi, Cristina, Venturello, Paolo, Umit, Calisir, Deagostino, Annamaria, Giulio, Goti, Dina, Scarpi, and Occhiato, Ernesto G.

Subjects
chemistry.chemical_classification, biology, Base (chemistry), Chemistry, Sonneratia hainanensis, Natural compound, Organic Chemistry, Sonogashira coupling, biology.organism_classification, Enol, Medicinal chemistry, Catalysis, chemistry.chemical_compound, Amide, Organic chemistry
Abstract

The gold(I)-catalyzed cyclization of N-Boc-protected 6-alkynyl-3,4-dihydro-2H-pyridines, prepared by the Sonogashira coupling of lactam-derived enol triflates or phosphates, provides vinylogous amides, which are useful intermediates in the synthesis of natural compounds. The Au(I)-catalyzed reaction is carried out with Ph3PAuOTf as a catalyst and proceeds via a 6-endo-dig cyclization to form a vinylgold species that after protodeauration generates a cyclic carbamate intermediate. This intermediate is in most cases not isolated, but the addition of a base to the reaction mixture rapidly and quantitatively delivers the target vinylogous amide. The first synthesis of a natural compound from Sonneratia hainanensis has been accomplished by this approach.

Published
2013

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