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OBJECTIVE: To assess the risk factors in developing poly cystic ovarian syndrome(PCOS), creating awareness and limiting them by advanced patient counseling. MATERIALS AND METHODS: An institutional and community based randomized observational study was conducted in RR institutions and general public over a period of six months. 200 participants who met the inclusion criteria were included in the study. The data was collected using self designed questionnaire and suitable statistical analysis was done. Self made PCOS score was used to access the severity. RESULTS: Out of 200 participants included in the study, majority (22.5%) of the participants belonged to age group of ≥ 25 years. On analysis of PCOS state it was found that 110 participants (55%) were with the chance for getting PCOS (score 5-9), 64 participants(32%) were with High risk of PCOS(score ≥ 10) and 26 participants (13%) were unpredictable to PCOS (score < 5).Among 64 participants with High risk of getting PCOS, majority(17) of the participants were at the age of ≥ 25 years. Among 110 participants with Chance of getting PCOS ,majority (20) of the participants were at the age of 21 years and among 26 participants with Unpredictable to PCOS , most of the participants were at the age of 19 years .Out of 200 participants 25 participants were found with complications. Among them Infertility problems (52%) was found to be the major one. CONCLUSION: The risk of PCOS increases with presence of one or more identified predisposing factors. Most of the factors tested as predisposing factors in our study are interlinked to each other and are mostly modifiable. Hence careful monitoring and proper management of identified predisposing factors not only delays but also helpful in adequate management of the disease.

Gitelman's syndrome is an inherited tubulopathy affecting thiazide-sensitive sodium chloride cotransporter, which manifests with hypokalemic alkalosis, hypomagnesemia, and hypocalciuria. Recently few cases have been described having an association of Gitelman's syndrome with pituitary abnormalities on imaging, though with normal hormonal status. We describe the first case of an adult patient having Gitelman's syndrome and hypopituitarism with abnormal pituitary imaging. She presented to us with hypotension, hypokalemia, hypomagnesemia with alkalosis, hypothyroidism, hypocortisolism, and hypogonadism. She was treated with replacement of electrolytes and hormones, to which she showed an excellent response.

In the title compound, C13H9ClN2O5S, the N—C bond in the C—SO2—NH—C segment has a gauche torsion with respect to the S=O bonds. The conformation between the N—H bond and the ortho-nitro group in the sulfonyl benzene ring is syn, and that between the C=O and the meta-Cl atom in the benzoyl ring is anti. The molecule is twisted at the S—N bond, with a torsion angle of 65.41 (38)°. The dihedral angle between the sulfonyl benzene ring and the –SO2—NH—C—O segment is 75.0 (1)°, and that between the sulfonyl and the benzoyl benzene ring is 89.1 (1)°. The crystal structure features inversion-related dimers linked by pairs of N—H...O(S) hydrogen bonds.