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Summary Many of the naturally fractured carbonate reservoirs of the Middle East exhibit low natural-depletion recoveries. The reason is that most of their oil reserves are stored in the low-permeability host rocks and are left behind by the fast advancing gas/oil contact (GOC) and water/oil contact (WOC) in fractures. Producing the remaining oil in the large gas-invaded zone of these reservoirs has been a crucial reservoir management issue. We show in this study using experimental observations, analytical calculations, and numerical investigations that repressurizing naturally fractured reservoirs (NFRs) by crestal immiscible gas injection has the potential to produce a large portion of this remaining oil by improving gravity drainage (GD) through two main mechanisms. One is that at higher pressures, the gas-oil interfacial tension (IFT) and hence the capillary forces that control recovery by GD are lessened, allowing additional recovery. This mechanism is aided by the other one, which is swelling of the oil at higher pressures. In this way, repressurization is thought to be not only a means for pressure maintenance but also a methodology for enhanced-oil recovery (EOR). This is confirmed by both laboratory studies and field performance of large-scale gas injection projects. Despite the desire for implementation of projects of repressurization, gas availability and cost of these projects are important concerns, requiring a cost-benefit analysis. Screening and ranking methodologies have been previously presented for some EOR techniques but not for repressurization by gas in NFRs. Evaluating the performance of gas injection in NFRs is often done using methodologies such as numerical simulations, which are in-depth, costly, and tedious. The methodology developed here is simple, requiring spreadsheet calculations. To develop the methodology, we first obtain simple relations to calculate additional GD recovery by considering the interplay of capillary and gravity forces in a matrix block subjected to pressurization by equilibrium gas injection and then use experimental data from literature to show that these relations can predict primary and secondary GD recoveries to a good approximation. We also show by mechanistic studies using a history-matched numerical model that IFT reduction and oil swelling are the main mechanisms contributing to additional oil recovery. Then, we propose a methodology to screen and rank candidate NFRs for gas injection that uses commonly available reservoir data and is based upon two criteria, these being additional oil recovered from a matrix block by pressurization and required volume of gas to produce an additional barrel of oil. We then implement this methodology to more than 20 Iranian NFRs and identify six reservoirs with potential for additional recovery of more than 20%. By quantifying and including the uncertainties associated with the reservoir data, we illustrate that for the reservoirs under study, capillary pressure parameters along with matrix-block height are the main parameters affecting GD recovery and should be characterized more accurately.

Because of the high approximation power and simplicity of computation of smooth radial basis functions (RBFs), in recent decades they have received much attention for function approximation. These RBFs contain a shape parameter that regulates the relation between their accuracy and stability. A difficulty in approximation via smooth RBFs is optimal selection of shape parameter. The aim of this paper is to introduce an alternative for smooth RBFs, which in addition to overcoming this difficulty, its approximation power is almost equal to RBFs....

With increased popularity and success of Machine-Learning (ML) Techniques, there is continued interest in developing new tools while exploring the boundaries of the technique. Here we use ML techniques to identify reservoir engineering, geological and development features that influence the ultimate recovery factor in a group of reservoirs, and to develop a model that provides the relation between recovery factor (RF) and these influencing features. Furthermore, we use techniques that allow opening the "black-box model" to decipher the relation between the model output and the individual features. The overall process included: (i) Creating a subset of reservoirs from the main database that included high quality reliable data, (ii) using SME (Subject Matter Expert) knowledge to develop a list of expected influential attributes, (iii) investigating the quality and the quantity of the data within each attribute and imputing when necessary, (iv) utilizing data analysis tools to reduce the number of input variables, and (v) examining the success of the model in modelling the test data. A Reservoir Complexity Index (RCI) factor was calculated using the 6 attributes identified and input into the ML model. For a dataset of approximately 18,000 reservoirs with high confidence in the recovery factor, a model was developed with 6 numerical features. The model exhibited an accuracy of ±5% for 50% of the data (between P25 and P75) and ±10% for 80% of the data (between P10 and P90). Contrary to our expectations, inclusion of the categorical features available in the reservoirs’ database did not improve the accuracy of the model. While this work falls within a growing category of similar work, its novelty is in demonstrating the strength of XGBoost in modelling and of SHapley Additive exPlanations (SHAP) in deciphering the relative contributions for each attribute of the model. Furthermore, we provided multiple examples to demonstrate and explore both the value and the limitations, and failure of application, of the ML techniques in this kind of work. This learning is important for a cautious but robust adaptation and acceptance of ML techniques.

Background & Objective: Breast cancer is one of the most common cancers in the world. Treatment methods for this disease have been with poor results. In recent years, more attention has been paid to stem cells due to their cytotoxic properties. According to previous results, the effect of nanoquercetin on breast cancer cells in this study was used concomitantly with doxorubicin, which is a chemotherapy drug and in some patients has therapeutic resistance. Materials & Methods: The above study was performed on MCF7 and BT474 human breast cancer cells. Quercetin was synthesized, then different concentrations of 10, 20, 40, 80 and 160 of quercetin and 1, 2.5, 5 and 10 μg/ml of doxorubicin were prepared and two cell lines were treated for 24 h. MTT test was used to determine cell viability and flow cytometry test was used to determine the extent of apoptosis in both cell lines. Results: The results showed that MCF7 and BT474 cells that were affected by quercetin and doxorubicin, increasing the concentration of quercetin and doxorubicin decreased the survival of both cell lines within 24 h. The LC50 concentration was calculated for both cells treated with nanoquercetin 40 μg/ml and for doxorubicin (0.1 mg/mL). The results also showed that in both cell lines, an increase in cellular apoptosis occurred after incubation with quercetin and then incubation with doxorubicin. Conclusion: Comparison of doxorubicin (DOX), quercetin (QU) and quercetin and doxorubicin (QU-DOX) groups with controls shows that with the presence of quercetin-doxorubicin, it had a greater inhibitory effect on cancer cells.

Background: There has been no validated instrument to identify barriers and facilitators to practicing preventive COVID-19 measures. Objectives: The present study aimed to develop and evaluate an instrument to identify facilitators and barriers to practicing COVID-19 preventive measures. Methods: The present study was conducted in two phases from September 2020 to December 2021. In the first phase, the researchers interviewed 20 residents of Sanandaj city, Iran, recruited using the purposive sampling method. Thematic analysis was done to elicit the initial codes from the interview scripts; then, themes were generated to develop the questions. In the second phase, psychometric properties of the test, including face validity, content validity, construct validity, and internal consistency, were investigated among 100 people using an online questionnaire. Afterward, the face, content, and construct validity were investigated through exploratory factor analysis. The entry criterion included people living in Sanandaj city, and the exit criterion was unwillingness to continue cooperation. Results: Participants included nine women and 11 men, with an average age of 28.95 years. After finishing the first phase of the study, 24 statements were generated. They were expanded into 31 statements after reviewing the related literature. The statements were categorized into three classes: adherence to practice, barriers, and facilitators. The results revealed five factors for adherence to practice, two factors for facilitators, and two factors for barriers. The instrument's reliability was reported at 0.91, calculated using Cronbach's alpha. Conclusions: The developed instrument might help investigate barriers and facilitators to practicing COVID-19 preventive measures. The findings may result in developing more effective strategies to promote practicing COVID-19 preventive measures.

Background: In various cancers, Ganoderic Acid A (GAA), an active triterpenoid derived from Ganoderma Background: Thalassemia refers to a category of inherited disorders resulting from defects in synthesizing one or several chains of hemoglobin (Hb). The present study aimed to determine the frequency of alpha and beta-thalassemia mutations in Kurdistan province, Iran. Materials and Methods: In this retrospective cross-sectional study, the laboratory data of 340 patients with thalassemia (170 females and 170 males), who were candidates for genetic testing in Kurdistan province, were examined over ten years (2006-2016). The participants were Kurd couples selected from the premarital health screening program. Results: In this demographic study, 20 beta mutations and nine alpha mutations were identified. Among the beta-thalassemia mutations, intervening sequence or intron No. 2- first nucleotide change as splice site mutation (IVS-II-1) (26.1%), codons 8/9 (14.8%), and intervening sequence or intron No. 1- first nucleotide (IVS-I-1) (12.2%) change as splice site mutation), had the highest frequency rates, respectively, constituting 53% of the beta mutations. In addition, α3.7(82.7%), -α4.2(8.3%), and --MED (Mediterranean deletion) (3.75%) were the most frequent alpha mutations, which constituted more than 90% of the alpha mutations. Conclusion: According to the results, the most frequent mutations in the HBB gene are IVS-II-1, Codons 8/9, and IVS-I-1, and in the HBA gene are α3.7, -α4.2, and –MED in Kurdistan province. In addition, the role of race and ethnicity as significant, influential factors in thalassemia was observable in the findings. The obtained results also indicated the communication pattern between the studied region's populations. Identifying common thalassemia mutations in an area could greatly benefit the early detection of thalassemia carriers in genetic laboratories and enhance thalassemia prevention programs.

The role of adiponectin in sperm function is inconclusive and there is a paucity of evidence. Obesity shows an ambiguous influence on sperm motility, and male subfertility. The aim of this study was to compare the role of adiponectin and sperm functional parameters among obese and non-obese men.In this comprehensive study, 64 male patients were included, and were classified as nonobese [body mass index (BMI)24.9 kg/mIn obese men, adiponectin gene expression (P0.0001) and protein levels (P0.001) were significantly lower compared to the non-obese group. Additionally, sperm motility, was significantly lower in the obese group. The rapid progressive (RP) motility was less in obese men in comparison to the non-obese group (P0.001). Sperm count and morphology were not significantly different in the two groups. DNA denaturation and DNA fragmentation were significantly more frequent in the obese group than in non-obese men (P0.05) and (P0.01), respectively. The obese men showed significantly lower sperm viability compared to the non-obese group (P0.05).This study showed no significant correlation between the evaluated variables (sperm parameter, sperm viability, DNA fragmentation and integrity), and obesity in men. Based on these results, adiponectin may potentially play positive role in sperm function for acquiring fertility.

Background: Despite the recommendations to follow guidelines for the prevention of COVID-19, different communities do not completely adhere to these guidelines. The aim of this study was to explore the barriers and facilitators of the adherence of the people of Sanandaj to the COVID-19 prevention guidelines. Materials & Methods: The present study was a qualitative content analysis study conducted in 2020. A purposive sampling method among the residents of Sanandaj, Iran was applied and continued until data saturation was achieved. Twenty semi-structured interviews were conducted with the participants. A verbatim transcription of interviews was analyzed through qualitative conventional content analysis. Results: Participants included 12 men and 8 women. Data analysis yielded 8 categories and 26 sub-categories regarding the barriers and facilitators of the participants’ adherence to the COVID-19 prevention guidelines. The barriers included myths, being under pressure, and letting and facilitators included awareness, fear, commitment, unity against the disease, and warnings. Conclusion: According to the findings, it is necessary to correct people’s beliefs, support them, and continue to make them informed about the disease. Increasing awareness and commitment, strengthening the spirit of unity among people, and increasing the level of warnings can be effective in increasing adherence of people to the COVID-19 prevention guidelines.

Background and Aim: Neurofibromatosis-1 (NF1) is a common genetic condition in children. It is becoming increasingly recognized that in neurofibromatosis, there might be anomalous development of bone with or without any local anomaly of neuroectodermal basis. This review was conducted to highlight the different features of spinal disorders in this congenital disease. Methods and Materials: Different search engines were used in this research. After going through the results and discarding the repeated ones, 2 reviewers began to inspect the studies independent of one another. In case of any disagreements between the reviewers over the inclusion of certain research material into the study, the final decision was made by the senior author. In the end, accepted research materials were used as needed in categorizing different types of spinal injuries. Results: Skeletal defects are among the most effective complications on the quality of life of patients. Bone deformities, osteoporosis, osteopenia, reduction of bone mass density, and spinal osteopathy such as scoliosis among such defects. Although the relative prevalence of spinal defects in neurofibromatosis type 1 is not clear, scoliosis can be considered the most common type of spinal deformity in this illness to the point it is present in 10 to 71% of cases. Thus, spine surgeons may face numerous common challenging conditions in NF1 patients like scoliosis, spondylolisthesis, and dural ectasia. Conclusion: As NF1 distresses several organ systems, radiologic spine screening is important in patients with NF1 and patients are likely to profit most from a multidisciplinary treatment policy.

St. Augustine, a Christian philosopher and prolocutor, and Avicenna, a Muslim philosopher and theologian, are both prominent personalities in philosophy and theology. “state Theory” is one of the key issues in political thought. Therefore, in this paper, we study and compare the issue from the viewpoints of the two philosophers in terms of the origin and nature of the government and its relation with conceptual, functional, and structural perspectives. Thus, the research question is: How can we conceptualize and compare Government Theory in Avicenna and St. Augustine’s political philosophy in terms of the origin and nature (of the government)? To address and examine the question, it is hypothesized that in Augustine’s viewpoint, the government is rooted in the human beings’ “first sin” and rebellious nature, having a customary nature, and its only function is maintaining security and peace in society. According to Avicenna’s theory, however, the government is originated in a divine and civil nature of human beings, being religious in nature, and its function is leading society towards the prosperity of this world and the salvation of the other world in an ideal way. The findings indicate that the starting point of each of the philosophers on human being’s nature determines the nature of the government in terms of the customary or religious nature and functional or structural perspectives. Therefore, in Augustine’s viewpoint, the government has an instrumental and mechanical approach; while, in Avicenna’s political viewpoint, the government has an organic approach from the conceptual perspective. Furthermore, Augustine’s theory is related to a realistic attitude, while, Avicenna’s theory is related to an idealistic approach. The inquiry uses a descriptive-analytical method and as library-based research has been carried out through careful analysis and evaluation of the existing literature and research on the subject.

Nowadays, investigations on the materials with multiferroic properties are in progress. These materials compromise simultaneous electric and magnetic properties. Ferrite Bismuth (FB) is one of the ceramic materials that enjoy this property and possesses three different crystalline structures (perovskite BiFeO3, selenite Bi25FeO40 and mullite Bi2Fe4O9). In this review, first, the crystalline structure and the electric and magnetic properties of Bi2Fe4O9 are studied, and then, the effects of adding dopants to the ferrite are discussed. Mullite-type bismuth ferrite (Bi2Fe4O9) as a spin frustrated multiferroic has potential for magnetoelectric coupling, and it might be an appropriate alternative for some of the multiferroics that suffer from a weak magnetoelectric coupling.

Proteome indicates the protein content of a genome. Proteome analysis is effective in a new system formulation and prediction, prevention, and treatment based on protein. One of the purposes of proteomics researches is to know and understand the cancer mechanism. In this study, we separated the proteins by the Two-Dimensional Electrophorese method and analyzed and compared protein spots by statistical and software data. The spots were separated and identified by the proteins' Isoelectric PH differences, molecular weights, and data bank. In continuation, the protein profiles were clustered by MALDI-TOF-TOF and the main element was identified and confirmed. We have used site PhosphoSitePlus® to review post-translational modifications. The findings indicated that the G protein Beta subunit rate increased in the astrocytoma, oligodendroglia, and glioblastoma cerebral malignant tumors. The βγ complex formation may prevent and activates many paths of cellular growth. The βγ complex activity control of the changes after the conversion parallel to GTPase activity of this α subunit may be a formulation mechanism for the G signal path (Tab. 5, Fig. 4, Diagram 2, Ref. 29). Keywords: glioma, G protein β subunit, proteomics.

Background & Objective: According to research, breast cancer is the second most common cancer among women. Nanomaterials of various materials significantly increase the solubility, stability and effective drug delivery, and in recent years research on the effectiveness of essential oils and plant extracts in inhibiting the growth of cancer cells is expanding. Artemisia belongs to the Asteraceae family. In many studies, the effectiveness of the essential oil and extract of this plant in inhibiting the growth of cancer cells has been reported. Materials & Methods: In this experiment, nanoparticles containing Artemisia absinthium L essential oil (thistle) were first synthesized by homogenizer & sonication method and then their physicochemical properties were determined, such as particle size, particle size distribution, zeta potential, percentage of loading efficiency. Then, the anti-apoptotic effect of lipid nanoparticles containing Artemisia essential oil in breast cancer cells (BRC-03) was evaluated. Results: The results of cellular effect of lipid nanoparticles containing essential oil of Artemisia absinthium L (thistle) on breast cancer cells showed that increasing the concentration of lipid nanoparticles containing essential oil of this plant reduced the survival rate of cancer cells. Breast (BRC-03) was purified compared to essential oil (p

Background & Objective: The Physalis alkekengi is a herbaceous plant belonging to Solanaceae family. According to research, this plant can help inhibit cancer cell growth. Materials & Methods: In this study, the extract of Physalis alkekengi was used to suppress angiogenesis in Balb/c mice. First, the MC4L2 cells were injected in the mice breastbone and the tumor began to grow in this area, then the mice were killed and the tumor removed from the mice and inserted in the test mice by surgical technique. Then, the mice were gavaged for 3 weeks at 50mg/kg and 100mg/kg daily Physalis alkekengi extract, and then the mice were killed and their tumor tissue removed, and tumor growth, apoptotic cell tissue and expression of VEGF gene were studied. Results: The results of this study showed that the hydroalcholic extract of Physalis alkekengi had a significant effect on tumor growth reduction in experimental groups 2 (50mg/kg body weight) and 3 (100 mg/kg) compared to the control group. Also, the results of the apoptotic cell in tissue showed that the extract of Physalis alkekengi significantly induced apoptotic and necrotic cells in experimental groups in comparison with the control group. The results of RT- PCR showed that the expression of VEGF gene in the experimental groups (50 mg/kg body weight) was significantly (P

The prevalence of pre-menopausal female infertility is increasing considerably due to various causes such as environmental pollutants, increased administration of chemotherapeutics and radiation exposure, microbial infections, and genetic/epigenetic alterations. However, the current therapeutical strategies remain unfavorite as the disadvantages are strongly challenging. Icariin (ICI) is a phytoestrogen that exerts some promising properties in order to alleviate female infertility. Therefore, the current literature review aimed to evaluate the conducted studies regarding the beneficial impacts of ICI on the female reproductive system and female fecundity. The findings of the present study revealed that ICI is able to modulate the levels of reproductive hormones as it causes a significant decrement in the levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) while increasing the levels of estrogen and progesterone. Furthermore, the administration of ICI results in a dramatic alteration in the expression of sex steroids’ receptors, particularly in female reproductive tissues. In addition, preserving ovarian follicular reserve, improving the ovarian and uterine histoarchitecture, elongating the estrous cycle duration, and eventually advancing the female fecundity are other major effects of ICI on the female reproductive system. Despite these desired beneficial properties, the current knowledge appears to be insufficient, hence further investigations, particularly on humans, are encouraged. To the best of our knowledge, this review provides a comprehensive information regarding the beneficial effects of Icariin on female infertility for the firs time

Spinal cord injury (SCI) is an injury of the spine that could be life-threatening and lead to partial or complete loss of autonomic, sensory, and motor function below the injured area. Surgery decompression and steroid injection are the current treatments for SCI, but neither is particularly effective, and there is a growing demand for a more potent treatment. Mesenchymal stem cells (MSCs) are novel therapeutic agents that were used in different inflammatory diseases. These cells have immunomodulatory and regenerative properties which make them a promising candidate for neurological disorders such as SCI. MSCs are easily expandable in vitro and have the capacity for multilineage differentiation. These cells, which can be derived from adipose tissue, bone marrow (BM), Wharton jelly, or umbilical cord, have immunomodulatory and paracrine capabilities. They can release a variety of cytokines and other substances that suppress the growth of B cells, T cells, and natural killer cells (NKCs) as well as alter the activity of dendritic cells (DCs). In this study, we reviewed clinical studies that showed the effects of MSCs from different sources in the SCI.

Evaluating satellite-based products is vital for precipitation estimation for sustainable water resources management. The current study evaluates the accuracy of predicting precipitation using four remotely sensed rainfall datasets—Tropical Rainfall Measuring Mission products (TRMM-3B42V7), Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks Climate Data Records (PERSIANN-CDR), Cloud Classification System-Climate Data Record (PERSIANN-CCS-CDR), and National Centers for Environmental Prediction (NCEP)-Climate Forecast System Reanalysis (CFSR)—over the Haraz-Gharehsoo basin during 2008–2016. The benchmark values for the assessment are gauge-observed data gathered without missing precipitation data at nine ground-based measuring stations over the basin. The results indicate that the TRMM and CCS-CDR satellites provide more robust precipitation estimations in 75% of high-altitude stations at daily, monthly, and annual time scales. Furthermore, the comparative analysis reveals some precipitation underestimations for each satellite. The underestimation values obtained by TRMM CDR, CCS-CDR, and CFSR are 8.93 mm, 20.34 mm, 9.77 mm, and 17.23 mm annually, respectively. The results obtained are compared to previous studies conducted over other basins. It is concluded that considering the accuracy of each satellite product for estimating remotely sensed precipitation is valuable and essential for sustainable hydrological modelling.

Ovarian cancer is the fifth reason for the woman's death. When cells get malignant changes in one or both ovaries, ovarian cancer gets formed. This kind of cancer when it is under control, it influenced the fertility of the patient. Artemisia Aucheri Boiss is used for most of the diseases to be healed. Due to the importance of ovarian cancer and the potential of anti-Apoptotic of Artemisia Aucheri Boiss, in this research the extraction of this plant in lipid nanoparticles with the target of cellular and molecular effects and anti Apoptotic loaded on the ovarian cancer cells. In this examination, first nanoparticles containing Artemisia extraction were synthesized by homogenizer plus sonication and subsequently their physical and chemical properties were determined like (size and shape of particles, description of particles, zeta potential, rate of efficiency of essential oil. Then the anti Apoptotic effect of lipid nanoparticle-containing Artemisia extraction in ovarian cancer cells (SKOV-3 line) was determined by MTT assay and flow cytometry analysis.Results of the cellular effects of lipid nanoparticle-containing extraction of the plant on the ovarian cancer cells show that the increase of viscosity of lipid nanoparticle containing the essence of this plant led to disease in the viability of ovarian cancer cells compared to pure essence. It seem that lipid nanoparticles appear to activate the apoptotic pathway in ovarian cancer cells.

The report of LMNB2‐related progressive myoclonus epilepsy and ataxia due to missense homozygous c.473G>T variant.

Aquaporins (AQPs) are water channel proteins. Up to now, 13 AQPs have been known in mammals. AQPs play a key role in water osmotic flow in various cells. the members of aquaporin protein family have been identified as H2O transposters across organelle and plasma membranes. AQPs of the aquaammoniaporin type are highly permeable for water and ammonia. In this study, we have evaluated the structure of AQP5 using two computational methods. We investigated the potential and kinetic energy, as well as maximum and minimum difference of atomic charge for AQP5. The atomic study of AQP5 protein showed that the minimum and maximum value of atomic charge in the presence and absence of water were related to sections (1-15). The water effect is generally considered to be the major driving force in the folding of AQP5. different sections of AQP5 behaved different in the presence or absence of water, and have different functionalities. Also, the absolute value of atomic charge difference for AQP5 sections was proven as an important feature in protein structural changes. HIGHLIGHTS •AQP5’s function and structure are dependent on the presence and absence of water. •The presence of water molecules around AQP5 protein causes changes in dynamic properties. •The optimum functions of AQP5 are arisen at low energy levels and the presence of water. •kinetic energy for AQP5 protein in mode of no water has the lowest fluctuations but in presence of water considerable fluctuations are seen.

The nanoparticles of Bi2Fe4-xMnxO9 (0.0 ≤ x ≤ 1.0) were synthesized using the reverse chemical co-precipitation method. The structural and microstructural studies of the synthesized powders were investigated by the X-ray diffractometery (XRD), Fourier-transformed infrared spectroscopy (FTIR) and field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM) and X-ray photoelectron spectrometer (XPS). The magnetic properties of nanoparticles were measured by a Vibrating Sample Magnetometer (VSM). The dielectric properties of the sintered samples were tested by the inductance-capacitance-resistance (LCR) meter equipment. The structural studies confirm the formation of the single phase of bismuth ferrite without impurities in all compositions. Microstructural observations showed that no significant changes occur in the size and shape of particles by increasing the manganese content. The produced nanoparticles are angular and pseudo-cubic-shaped and the average particle size in each sample is about 130 nm. The magnetic measurement revealed that as the Mn content increases, the coercivity increases noticeably and the saturation magnetization decreases slightly. Also, the dielectric constant was enhanced due to the Mn addition.

Introduction: This research aimed to study the relationship between role overload and organization deviant behaviors with intermediary role of emotional exhaustion. Method: The research is applied and correlation. The statistical population includes all nurses and administrative staff of Bojnoord Imam Ali hospital 325 people and according to Krejcie- Morgan table, sample size of 152 was calculated and people were randomly selected to complete questionnaires. The data collection was used Bodankin and Tziner organization deviant behaviors (2009), role overload (1990) and Maslach and Jackson emotional exhaustion (1981). The validity questionnaires was confirmed of content and nominal. The reliability questionnaires was confirmed by Cronbach's alpha value of 834% organizational deviant behavior questionnaire, role overload 812% and 796% respectively emotional exhaustion. To test the hypothesis, the structural equation model was used and the application Lisrel. Results: showed there was organizational role overload with deviant behaviors indirect and mediated by emotional exhaustion significantly correlation amount 23%, between role overload with deviant behaviors significant relationship amount 0/593 and significant relationship between role overload and emotional exhaustion among employees to 0/389. To compare the means of the population by two independent random samples of populations was used of two-sample T-test and results showed that gender and role overload variables affect service records, not emotional exhaustion and organizational deviant behaviors. Conclusion: Results indicate that the organizational role overload with deviant behaviors, there is no direct relationship and indirectly causing deviant behaviors are mediated by emotional exhaustion so managers and planners need to carefully consider the emotional states and psychiatric staff.

Breast cancer is among leading causes of death due to cancers around the globe. Current therapeutic approaches towards healing of breast cancer have been associated with poor outcomes. Graphene and its derivatives have a two-dimensional flat structure, which is characterized by the ability to carry drugs and modify the surface, low cytotoxicity and high biocompatibility. This study was performed on MCF7 and BT474 human breast cancer cells. Different concentrations of doxorubicin (DOX), graphene oxide (GO) and graphene oxide plus doxorubicin (GO-DOX) were subjected to both cell lines at specified intervals. At the end of the treatments, MTT test was applied to determine the viability of cells and then flow cytometry, colony formation and spheroid tests were implemented for both cell lines treated with DOX, GO and GO-DOX components. We used DLS and TEM to confirm the GO properties. According to the MTT test results, 1 µL of DOX at 10 mg /mL (equivalent to 0.1 mg / mL) caused 50% survival of MCF7 cells at 24 hours. In both cell lines, an increase in apoptosis occurred after incubation with GO and DOX. Although, a rate of mortality of MCF-7 cells was due to necrosis, the BT474 cells death was merely through the apoptosis. Furthermore, the results of colony formation test outlined an enhancing inhibitory effect in the presence of GO-DOX as a comparison to the control. Additionally, spheroids formed following treatment with GO-DOX exhibited a significant decrease compared to their control group; with an increase in the number of spheroids in BT474 cells compared to those in the MCF-7. The decreasing effect of compounds against the migration and cell invasion potential was also observed, being higher in MCF7 than BT474 cells. The effects of cytotoxic GO were observed at higher concentrations.

Magnetically modified nanomaterials have recently gained a great attention in wastewater treatment. In this study, the uptake process of methylene blue (MB) and methyl violet (MV) from aqueous media using wheat bran sawdust/Fe3O4 composite was studied. To specify the surface and structural properties of the wheat bran sawdust/Fe3O4 composite, various analyses such as FTIR, XRD, EDX, Map, TGA/DTG, SEM, VSM, and BET were performed. The results of BET analysis indicated that the specific surface area of the aforementioned composite was 74.25 m2/g, and the average pore size was 65.7A, which indicates that the composite has a mesoporous structure. Also, VSM analysis indicated that the composite has a paramagnetic property with a magnetic saturation of 28.29 emu/g and can be easily eliminated from the aqueous solution by a magnet. Moreover, the highest removal efficiency of MB and MV dyes using the wheat bran/Fe3O4 composite was obtained as 97.46 and 98.75%, respectively, which were significant values. These removal efficiencies were obtained at contact time of 50 min and pH values of 9 and 8 for MB and MV, respectively. Furthermore, the outcomes of equilibrium study showed that the Langmuir model with a correlation coefficient greater than 0.98 describes the equilibrium behavior of the uptake process better than the Freundlich and Dubinin-Radushkevich models. Besides, the maximum sorption capacity of MV and MB dyes using the Langmuir model was obtained as 46.08 and 51.28 mg/g, respectively. Also, the uptake process followed the pseudo-second-order kinetic model, and the thermodynamic study indicated that the uptake process is exothermic and spontaneous.

Magnetically modified nanomaterials have recently gained a great attention in wastewater treatment. In this study, the uptake process of methylene blue (MB) and methyl violet (MV) from aqueous media using wheat bran sawdust/Fe

Microfluidic systems and their combinations with the analytical devices have provided a novel platform for manufacturing innovative structures for different tasks in the food industries. Especially, regarding the dairy products wherein the milk acidification rate and eventual contamination play a significant role in the quality of the final product. Spoiled milk can cause numerous bacterial diseases such as Salmonella, E. coli, Listeria, and Campylobacter. Hence, distinguishing the milk sample with desirable qualities from the spoiled ones is an ongoing issue among health-related organizations and beverage industries. Here, we demonstrate an analytical microfluidic-based method that can quantitatively differentiate the fresh pasteurized milk from the spoiled ones in less than 4 minutes. The method is based on the transient current vs voltage variations recorded along a microchannel filled with the analyte. In this method, only a 100 microliter sample of the analyte is sufficient for each test. The channel and electrode materials are of low cost and the device can be miniaturized as disposable units.

Obesity, Vitamin D (VD) deficiency, and infertility are important ubiquitous issue; however, the association of obesity and serum VD levels with abnormal sperm is unclear and inconclusive. The current study investigated the correlation of obesity and serum VD levels with sperm DNA integrity and sperm parameters in normozoospermia men.Semen and blood samples from 64 men were divided into two groups: obese and nonobese men based on body mass index (BMI). Sperm motility and viability were determined by computer-aided sperm analysis and eosin-nigrosin staining. DNA fragmentation, determined by sperm chromatin dispersion method. VD concentrations were assessed by the Elisa technique.Serum concentration of VD levels in the obese group was significantly lower than nonobese men (VD deficiency in the obese group showed decreased sperm motility, increased DNA damage, and viability. Adverse consequences of obesity and the possible effect of BMI infertility treatment must be discussed with counseling couples interested in assisted reproductive techniques outcomes, especially in men without any unknown cause.

Background: Proteomics is considered a new era in neurophysiological/ neuropathological research including brain tumors. Gliomas which are derived from glial cells are the most common type of brain tumor in humans. Methods: In the present study the total protein content of healthy cells of the brain and brain tumor cells was extracted, purified and quantified by Bradford assay. Two-dimensional electrophoresis were used for protein separation followed by statistical analysis. Primary protein detection was performed based on the differences in isoelectric pH, molecular weight of proteins and protein data banks, which was further confirmed by MALDI-TOF/TOF mass spectrometry (MS). Results: Our results showed elevated levels of beta-actin protein expression in glioma brain tumor cells. It is important to know when a cell is transformed and when it becomes malignant. Here we evaluated the beta-actin expression in malignant cells. Conclusion: Since structural changes are highly involved in tumor cell malignancy, beta-actin elevations can contribute in glioma tumor cell invasiveness.

Metal oxides combined with porous carbon nanostructures as the active substance in supercapacitor electrodes have been considered by many researchers. In this study, the electrochemical performance of metal oxide nanoparticles and nanorods for application in supercapacitors has been studied. Bi2O3 nanoparticles and nanorods with carbon aerogel (CA) template are combined in a nanocomposite structure via one-pot synthesis technique. Regarding the high surface area (686 m2 g−1), this nanocomposite showed a good electrochemical performance and the corresponding electrode achieved an specific capacity of 1193 F g−1 at 1 A g−1 current density in a 3-electrode system while the specific capacity of CA-Bi2O3 electrodes were 135 F g−1 and 672 F g−1, respectively at the same current density. Moreover, in the pr-Bi2O3-CA electrode, the capacity was reduced 5.3% by 6000 cycles showing cyclic stability due to fast charge transfer during the electrochemical process. A cell has been fabricated using pr-Bi2O3-CA and CNF electrodes resulting in a high performance supercapacitor with 15975 W kg−1 and 44.45 Wh kg−1 specific power and specific energy, respectively. The performance of this supercapacitor is much higher than general capacitors and close to NI-MH batteries. Red Light-Emitting Diode (LED) is also lit successfully by two supercapacitors in series. Based on the results, the suitable electrochemical efficiency of pr-Bi2O3-CA electrode approves a promising alternative for energy storage.

Background: General physicians play a significant role in the health management of crises. In order to enhance the knowledge and skills of medical students on how to address health-related issues in crises and to promote their ability to manage and deal with such crises after graduation, appropriate training is necessary. Methods: Applying the Delphi method, 103 experts with field experience in health management and crises were invited to participate in the study. The Delphi study provided aggregation of the opinions and extracted the topics. Conventional content analysis was used to make sense of qualitative data gathered during the study. Results: Among the feedback (n = 66) obtained in the first round, a primary list was extracted including 27 topics and 97 single items. Nineteen major topics, encompassing 97 items, were finally determined in the subsequent rounds. The participants agreed to teach this course at the beginning the internship period via different methods of instruction. Conclusion: This study indicated that health management in crises is important and must be taught in medicine. This study provided a blueprint and an educational rationale as well as contents and structure of a course on health management in crisis to be delivered in undergraduate medical education.

By introduction of two scalar potentials, an analytical method is developed for the solution of poroelastodynamic boundary value problems in transversely isotropic fluid-saturated poroelastic media. The governing equations of motion are considered in the framework of Biot's complete model without any assumption or simplification. As a case of application, solutions in three dimensions for a transversely isotropic fluid saturated porous half space loaded by an arbitrary distribution of time harmonic tractions at the free surface is derived. The free surface of the half space may be considered either permeable or impermeable. As a particular solution, Green's functions for uniform vertical and horizontal circular patch loads are presented as semi-infinite integrals which may be evaluated by means of an appropriate numerical method proposed. The accuracy of the solutions is verified both analytically and numerically against the preceding solutions. Some numerical results are also presented to clarify the influence of different degrees of anisotropy and frequency of excitation on the response of the medium.

Purpose: The non-invasive imaging and quantification of L-type calcium channels (also known as dihydropyridine channels) in living tissues is of great interest in diagnosis of congestive heart failure, myocardial hypertrophy, irritable bowel syndrome etc. Methods: Technetium-99m labeled amlodipine conjugate ([99mTc]-DTPA-AMLO) was prepared starting freshly eluted (99%, RTLC; specific activity: 55-60 GBq/mmol). The calcium channel blockade activity (CCBA) and apoptosis/necrosis assay of DTPA-amlodipine conjugate evaluations were performed for the conjugate. Log P, stability, bio-distribution and imaging studies were performed for the tracer followed by biodistribution studies as well as imaging. Results: The conjugate demonstrated low toxicity on MCF-7 cells and CCBA (at µm level) compared to the amlodipine. The tracer was stable up to 4 h in final production and presence of human serum and log P (-0.49) was consistent with a water soluble complex. The tracer was excreted through kidneys and liver as expected for dihydropyridines; excluding excretory organs, calcium channel rich smooth muscle cells; including colon, intestine and lungs which demonstrated significant uptake. SPECT images supported the bio-distribution data up to 4 h. Conclusion: significant uptake of [99mTc]-DTPA-AMLO was obtained in calcium channel rich organs. The complex can be a candidate for further SPECT imaging for L-type calcium channels.