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2. A DNA-polymerase-related reading frame (pol-r) in the mtDNA of Secale cereale

Author

Gabriel Dohmen and Paul Tudzynski

Subjects
Transcription, Genetic, DNA polymerase, Molecular Sequence Data, Restriction Mapping, DNA-Directed DNA Polymerase, Genes, Plant, DNA, Mitochondrial, Zea mays, Open Reading Frames, Start codon, Species Specificity, Sequence Homology, Nucleic Acid, Genetics, Consensus sequence, Amino Acid Sequence, Cloning, Molecular, Promoter Regions, Genetic, Gene, Polymerase, Triticum, DNA Primers, biology, Base Sequence, Sequence Homology, Amino Acid, Secale, Nucleic acid sequence, General Medicine, Molecular biology, Open reading frame, Codon usage bias, Infertility, biology.protein, RNA Editing
Abstract

Mitochondrial (mt)DNA of Secale cereale contains an open reading frame (pol-r), the potential translation product of which shows significant homology to the type-B DNA polymerase encoded by the S1 plasmid of Zea mays; it contains the highly-conserved domains IIa to V of family B polymerases. The pol-r ORF is transcribed, as proven by RT-PCR, but the transcript is not edited. Upstream of the putative start codon a potential promoter motif was detected, fitting well into the postulated consensus sequence of the transcription initiation regions of Z. mays and Triticum aestivum. The pol-r ORF occurs in mtDNA of the fertile rye variety "Halo" and the cytoplasmic male-sterile (CMS) line "Pampa". Both ORFs are almost identical, apart from the 3' terminus; pol-r from Halo can code for 289 amino acids, pol-r from Pampa for 312 amino acids. Based on codon usage and the lack of editing, pol-r is considered to be a "young" gene, probably introduced in the mtDNA of rye by recombination with an mt plasmid.

Published
1994

3. Association of Hospital Volume with Perioperative Mortality of Endovascular Repair of Complex Aortic Aneurysms: A Nationwide Cohort Study

Author

Alberga, Anna J., von Meijenfeldt, Gerdine C. I., Rastogi, Vinamr, de Bruin, Jorg L., Wever, Jan J., van Herwaarden, Joost A., Hamming, Jaap F., Hazenberg, Constantijn E. V. B., van Schaik, Jan, Mees, Barend M. E., van der Laan, Maarten J., Zeebregts, Clark J., Schurink, Geert W. H., Verhagen, Hence J. M., van den Akker, P. J., Akkersdijk, G. P., Akkersdijk, W. L., van Andringa de Kempenaer, M. G., Arts, C. H. P., Avontuur, A. M., Bakker, O. J., Balm, R., Barendregt, W. B., Bekken, J. A., Bender, M. H. M., Bendermacher, B. L. W., van den Berg, M., Beuk, R. J., Blankensteijn, J. D., Bode, A. S., Bodegom, M. E., van der Bogt, K. E. A., Boll, A. P. M., Booster, M. H., Borger van der Burg, B. L. S., de Borst, G. J., Bos-van Rossum, W. T. G. J., Bosma, J., Botman, J. M. J., Bouwman, L. H., Brehm, V., de Bruijn, M. T., de Bruin, J. L., Brummel, P., van Brussel, J. P., Buijk, S. E., Buimer, M. G., Buscher, H. C. J. L., Cancrinus, E., Castenmiller, P. H., Cazander, G., Cuypers, P. W. M., Daemen, J. H. C., Dawson, I., Dierikx, J. E., Dijkstra, M. L., Diks, J., Dinkelman, M. K., Dirven, M., Dolmans, D. E. J. G. J., van Dortmont, L. M. C., Drouven, J. W., van der Eb, M. M., Eefting, D., van Eijck, G. J. W. M., Elshof, J. W. M., Elsman, A. H. P., van der Elst, A., van Engeland, M. I. A., van Eps, G. S., Faber, M. J., de Fijter, W. M., Fioole, B., Fritschy, W. M., Fung Kon Jin, P. H. P., Geelkerken, R. H., van Gent, W. B., Glade, G. J., Govaert, B., Groenendijk, R. P. R., de Groot, H. G. W., van den Haak, R. F. F., de Haan, E. F. A., Hajer, G. F., Hamming, J. F., van Hattum, E. S., Hazenberg, C. E. V. B., Hedeman Joosten, P. P. A., Helleman, J. N., van der Hem, L. G., Hendriks, J. M., van Herwaarden, J. A., Heyligers, J. M. M., Hinnen, J. W., Hissink, R. J., Ho, G. H., den Hoed, P. T., Hoedt, M. T. C., van Hoek, F., Hoencamp, R., Hoffmann, W. H., Hoksbergen, A. W. J., Hollander, E. J. F., Huisman, L. C., Hulsebos, R. G., Huntjens, K. M. B., Idu, M. M., Jacobs, M. J. H. M., van der Jagt, M. F. P., Jansbeken, J. R. H., Janssen, R. J. L., Jiang, H. H. L., de Jong, S. C., Jongbloed-Winkel, T. A., Jongkind, V., Kapma, M. R., Keller, B. P. J. A., Jahrome, A. Khodadade, Kievit, J. K., Klemm, P. L., Klinkert, P., Koedam, N. A., Koelemaij, M. J. W., Kolkert, J. L. P., Koning, G. G., Koning, O. H. J., Konings, R., Krasznai, A. G., Kropman, R. H. J., Kruse, R. R., van der Laan, L., van der Laan, M. J., van Laanen, J. H. H., van Lammeren, G. W., Lamprou, D. A. A., Lardenoije, J. H. P., Lauret, G. J., Leenders, B. J. M., Legemate, D. A., Leij-Dekkers, V. J., Lemson, M. S., Lensvelt, M. M. A., Lijkwan, M. A., van der Linden, F. T. P. M., Lung, P. F. L., Loos, M. J. A., Loubert, M. C., van de Luijtgaarden, K. M., Mahmoud, D. E. A. K., Manshanden, C. G., Mat-Tens, E. C. J. L., Meerwaldt, R., Mees, B. M. E., Menting, T. P., Metz, R., de Mol van Otterloo, J. C. A., Molegraaf, M. J., Montauban van Swijn-Dregt, Y. C. A., Morak, M. J. M., van de Mortel, R. H. W., Mulder, W., Nagesser, S. K., Naves, C. C. L. M., Nederhoed, J. H., Nevenzel, A. M., de Nie, A. J., Nieuwenhuis, D. H., van Nieuwenhuizen, R. C., Nieuwenhui-Zen, J., Nio, D., Oomen, A. P. A., Oranen, B. I., Oskam, J., Palamba, H. W., Peppelenbosch, A. G., van Petersen, A. S., Petri, B. J., Pierie, M. E. N., Ploeg, A. J., Pol, R. A., Ponfoort, E. D., Poyck, P. P. C., Prent, A., ten Raa, S., Raymakers, J. T. F. J., Reichmann, B. L., Reijnen, M. M. P. J., de Ridder, J. A. M., Rijbroek, A., van Rijn, M. J. E., de Roo, R. A., Rouwet, E. V., Saleem, B. R., van Sambeek, M. R. H. M., Samyn, M. G., van't Sant, H. P., van Schaik, J., van Schaik, P. M., Scharn, D. M., Scheltinga, M. R. M., Schepers, A., Schlejen, P. M., Schlösser, F. J. V., Schol, F. P. G., Scholtes, V. P. W., Schouten, O., Schreve, M. A., Schurink, G. W. H., Sikkink, C. J. J. M., te Slaa, A., Smeets, H. J., Smeets, L., Smeets, R. R., de Smet, A. A. E. A., Smit, P. C., Smits, T. M., Snoeijs, M. G. J., Sondakh, A. O., Speijers, M. J., van der Steenhoven, T. J., van Sterkenburg, S. M. M., Stigter, D. A. A., Stokmans, R. A., Strating, R. P., Stultiëns, G. N. M., Sybrandy, J. E. M., Teijink, J. A. W., Telgenkamp, B. J., Testroote, M. J. G., Tha-in, T., The, R. M., Thijsse, W. J., Thomassen, I., Tielliu, I. F. J., van Tongeren, R. B. M., Toorop, R. J., Tournoij, E., Truijers, M., Türkcan, K., Nolthenius, R. P. Tutein, Ünlü, C., Vaes, R. H. D., Vahl, A. C., Veen, E. J., Veger, H. T. C., Veldman, M. G., Verhagen, H. J. M., Verhoeven, B. A. N., Vermeulen, C. F. W., Vermeulen, E. G. J., Vierhout, B. P., van der Vijver-Coppen, R. J., Visser, M. J. T., van der Vliet, J. A., van Vlijmen-van Keulen, C. J., van der Vorst, J. R., Vos, A. W. F., Vos, C. G., Vos, G. A., de Vos, B., Voûte, M. T., Vriens, B. H. R., Vriens, P. W. H. E., de Vries, D. K., de Vries, J. P. P. M., de Vries, M., de Vries, A. C., van der Waal, C., Waasdorp, E. J., de Vries, B. M. Wallis, van Walraven, L. A., van Wanroi, J. L., Warlé, M. C., van Weel, V., van Well, A. M. E., Welten, G. M. J. M., Wever, J. J., Wiersema, A. M., Wikkeling, O. R. M., Willaert, W. I. M., Wille, J., Willems, M. C. M., Willigendael, E. M., Wilschut, E. D., Wisselink, W., Witte, M. E., Wittens, C. H. A., Wong, C. Y., Yazar, O., Yeung, K. K., Zeebregts, C. J. A. M., van Zeeland, M. L. P., Physiology, ACS - Pulmonary hypertension & thrombosis, Surgery, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, VU University medical center, AII - Inflammatory diseases, APH - Digital Health, Medical Biochemistry, ACS - Diabetes & metabolism, AII - Infectious diseases, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
volume-outcome, complex AAA, endovascular, mortality
Abstract

Objective: We evaluate nationwide perioperative outcomes of complex EVAR and assess the volume-outcome association of complex EVAR. Summary of Background Data: Endovascular treatment with fenestrated (FEVAR) or branched (BEVAR) endografts is progressively used for excluding complex aortic aneurysms (complex AAs). It is unclear if a volumeoutcome association exists in endovascular treatment of complex AAs (complex EVAR). Methods: All patients prospectively registered in the Dutch Surgical Aneurysm Audit who underwent complex EVAR (FEVAR or BEVAR) between January 2016 and January 2020 were included. The effect of annual hospital volume on perioperative mortality was examined using multivariable logistic regression analyses. Patients were stratified into quartiles based on annual hospital volume to determine hospital volume categories. Results: We included 694 patients (539 FEVAR patients, 155 BEVAR patients). Perioperative mortality following FEVAR was 4.5% and 5.2% following BEVAR. Postoperative complication rates were 30.1% and 48.7%, respectively. The first quartile hospitals performed

Published
2023
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4. Treatment Outcome Trends for Non-Ruptured Abdominal Aortic Aneurysms: A Nationwide Prospective Cohort Study

Author

Alberga, Anna J., Karthaus, Eleonora G., Wilschut, Janneke A., de Bruin, Jorg L., Akkersdijk, George P., Geelkerken, Robert H., Hamming, Jaap F., Wever, Jan J., Verhagen, Hence J. M., van den Akker, P. J., Akkersdijk, G. P., Akkersdijk, W. L., van Andringa de Kempenaer, M. G., Arts, C. H. P., Avontuur, A. M., Bakker, O. J., Balm, R., Barendregt, W. B., Bekken, J. A., Bender, M. H. M., Bendermacher, B. L. W., van den Berg, M., Beuk, R. J., Blankensteijn, J. D., Bode, A. S., Bodegom, M. E., van der Bogt, K. E. A., Boll, A. P. M., Booster, M. H., Borger van der Burg, B. L. S., de Borst, G. J., Bos-van Rossum, W. T. G. J., Bosma, J., Botman, J. M. J., Bouwman, L. H., Brehm, V., de Bruijn, M. T., de Bruin, J. L., Brummel, P., van Brussel, J. P., Buijk, S. E., Buimer, M. G., Buscher, H. C. J. L., Cancrinus, E., Castenmiller, P. H., Cazander, G., Cuypers, P. H. W. M., Daemen, J. H. C., Dawson, I., Dierikx, J. E., Dijkstra, M. L., Diks, J., Dinkelman, M. K., Dirven, M., Dolmans, D. E. J. G. J., van Dortmont, L. M. C., Drouven, J. W., van der Eb, M. M., Eefting, D., van Eijck, G. J. W. M., Elshof, J. W. M., Elsman, B. H. P., van der Elst, A., van Engeland, M. I. A., van Eps, G. S., Faber, M. J., de Fijter, W. M., Fioole, B., Fritschy, W. M., Jin, P. H. P. F. K., Geelkerken, R. H., van Gent, W. B., Glade, G. J., Govaert, B., Groenendijk, R. P. R., de Groot, H. G. W., van den Haak, R. F. F., de Haan, E. F. A., Hajer, G. F., Hamming, J. F., van Hattum, E. S., Hazenberg, C. E. V. B., Hedeman Joosten, P. P. H. A., Helleman, J. N., van der Hem, L. G., Hendriks, J. M., van Herwaarden, J. A., Heyligers, J. M. M., Hinnen, J. W., Hissink, R. J., Ho, G. H., den Hoed, P. T., Hoedt, M. T. C., van Hoek, F., Hoencamp, R., Hoffmann, W. H., Hoksbergen, A. W. J., Hollander, E. J. F., Huisman, L. C., Hulsebos, R. G., Huntjens, K. M. B., Idu, M. M., Jacobs, M. J. H. M., van der Jagt, M. F. P., Jansbeken, J. R. H., Janssen, R. J. L., Jiang, H. H. L., de Jong, S. C., Jongbloed-Winkel, T. A., Jongkind, V., Kapma, M. R., Keller, B. P. J. A., Jahrome, A. K., Kievit, J. K., Klemm, P. L., Klinkert, P., Koedam, N. A., Koelemaij, M. J. W., Kolkert, J. L. P., Koning, G. G., Koning, O. H. J., Konings, R., Krasznai, A. G., Kropman, R. H. J., Kruse, R. R., van der Laan, L., van der Laan, M. J., van Laanen, J. H. H., van Lammeren, G. W., Lamprou, D. A. A., Lardenoije, J. H. P., Lauret, G. J., Leenders, B. J. M., Legemate, D. A., Leijdekkers, V. J., Lemson, M. S., Lensvelt, M. M. A., Lijkwan, M. A., van der Linden, F. T. H. P. M., Lung, P. F. Liqui, Loos, M. J. A., Loubert, M. C., van de Luijtgaarden, K. M., Mahmoud, D. E. A. K., Manshanden, C. G., Mattens, E. C. J. L., Meerwaldt, R., Mees, B. M. E., Menting, T. P., Metz, R., de Mol van Otterloo, J. C. A., Molegraaf, M. J., Montauban van Swijndregt, Y. C. A., Morak, M. J. M., van de Mortel, R. H. W., Mulder, W., Nagesser, S. K., Naves, C. C. L. M., Nederhoed, J. H., Nevenzel, A. M., de Nie, A. J., Nieuwenhuis, D. H., van Nieuwenhuizen, R. C., Nieuwenhuizen, J., Nio, D., Oomen, A. P. A., Oranen, B. I., Oskam, J., Palamba, H. W., Peppelenbosch, A. G., van Petersen, A. S., Petri, B. J., Pierie, M. E. N., Ploeg, A. J., Pol, R. A., Ponfoort, E. D., Poyck, P. P. C., Prent, A., Raa, S. ten, Raymakers, J. T. F. J., Reichmann, B. L., Reijnen, M. M. P. J., de Ridder, J. A. M., Rijbroek, A., van Rijn, M. J. E., de Roo, R. A., Rouwet, E. V., Saleem, B. R., van Sambeek, M. R. H. M., Samyn, M. G., van ’t Sant, H. P., van Schaik, J., van Schaik, P. M., Scharn, D. M., Scheltinga, M. R. M., Schepers, A., Schlejen, P. M., Schlösser, F. J. V., Schol, F. P. G., Scholtes, V. P. W., Schouten, O., Schreve, M. A., Schurink, G. W. H., Sikkink, C. J. J. M., Slaa, A. te, Smeets, H. J., Smeets, L., Smeets, R. R., de Smet, A. A. E. A., Smit, P. C., Smits, T. M., Snoeijs, M. G. J., Sondakh, A. O., Speijers, M. J., van der Steenhoven, T. J., van Sterkenburg, S. M. M., Stigter, D. A. A., Stokmans, R. A., Strating, R. P., Stultiëns, G. N. M., Sybrandy, J. E. M., Teijink, J. A. W., Telgenkamp, B. J., Testroote, M. J. G., Tha-in, T., The, R. M., Thijsse, W. J., Thomassen, I., Tielliu, I. F. J., van Tongeren, R. B. M., Toorop, R. J., Tournoij, E., Truijers, M., Türkcan, K., Tutein Nolthenius, R. P., Ünlü, C., Vaes, R. H. D., Vahl, A. C., Veen, E. J., Veger, H. T. C., Veldman, M. G., Verhagen, H. J. M., Verhoeven, B. A. N., Vermeulen, C. F. W., Vermeulen, E. G. J., Vierhout, B. P., van der Vijver-Coppen, R. J., Visser, M. J. T., van der Vliet, J. A., van Vlijmen - van Keulen, C. J., van der Vorst, J. R., Vos, A. W. F., Vos, C. G., Vos, G. A., de Vos, B., Voûte, M. T., Vriens, B. H. R., Vriens, P. W. H. E., de Vries, D. K., de Vries, J. P. P. M., de Vries, M., de Vries, A. C., van der Waal, C., Waasdorp, E. J., Wallis de Vries, B. M., van Walraven, L. A., van Wanroi, J. L., Warlé, M. C., van Weel, V., van Well, A. M. E., Welten, G. M. J. M., Wever, J. J., Wiersema, A. M., Wikkeling, O. R. M., Willaert, W. I. M., Wille, J., Willems, M. C. M., Willigendael, E. M., Wilschut, E. D., Wisselink, W., Witte, M. E., Wittens, C. H. A., Wong, C. Y., Yazar, O., Yeung, K. K., Zeebregts, C. J. A. M., van Zeeland, M. L. P., ACS - Microcirculation, Anesthesiology, Physiology, ACS - Pulmonary hypertension & thrombosis, Surgery, ACS - Atherosclerosis & ischemic syndromes, VU University medical center, ACS - Diabetes & metabolism, TechMed Centre, Multi-Modality Medical Imaging, Medical Biochemistry, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

Subjects
Male, Time Factors, Operative procedure, Vascular damage Radboud Institute for Health Sciences [Radboudumc 16], Risk Assessment, Blood Vessel Prosthesis Implantation, Postoperative Complications, Risk Factors, Humans, Hospital Mortality, Prospective Studies, Registries, Treatment outcome, Aged, Netherlands, Retrospective Studies, Aged, 80 and over, Endovascular Procedures, Quality of care, Middle Aged, Endovascular procedure, Abdominal aortic aneurysm, Surgery, Female, Trends, Cardiology and Cardiovascular Medicine, Aortic Aneurysm, Abdominal
Abstract

Contains fulltext : 251573.pdf (Publisher’s version ) (Open Access) OBJECTIVE: The Dutch Surgical Aneurysm Audit (DSAA) initiative was established in 2013 to monitor and improve nationwide outcomes of aortic aneurysm surgery. The objective of this study was to examine whether outcomes of surgery for intact abdominal aortic aneurysms (iAAA) have improved over time. METHODS: Patients who underwent primary repair of an iAAA by standard endovascular (EVAR) or open surgical repair (OSR) between 2014 and 2019 were selected from the DSAA for inclusion. The primary outcome was peri-operative mortality trend per year, stratified by OSR and EVAR. Secondary outcomes were trends per year in major complications, textbook outcome (TbO), and characteristics of treated patients. The trends per year were evaluated and reported in odds ratios per year. RESULTS: In this study, 11 624 patients (74.8%) underwent EVAR and 3 908 patients (25.2%) underwent OSR. For EVAR, after adjustment for confounding factors, there was no improvement in peri-operative mortality (aOR [adjusted odds ratio] 1.06, 95% CI 0.94 - 1.20), while major complications decreased (2014: 10.1%, 2019: 7.0%; aOR 0.91, 95% CI 0.88 - 0.95) and the TbO rate increased (2014: 68.1%, 2019: 80.9%; aOR 1.13, 95% CI 1.10 - 1.16). For OSR, the peri-operative mortality decreased (2014: 6.1%, 2019: 4.6%; aOR 0.89, 95% CI 0.82 - 0.98), as well as major complications (2014: 28.6%, 2019: 23.3%; aOR 0.95, 95% CI 0.91 - 0.99). Furthermore, the proportion of TbO increased (2014: 49.1%, 2019: 58.3%; aOR 1.05, 95% CI 1.01 - 1.10). In both the EVAR and OSR group, the proportion of patients with cardiac comorbidity increased. CONCLUSION: Since the establishment of this nationwide quality improvement initiative (DSAA), all outcomes of iAAA repair following EVAR and OSR have improved, except for peri-operative mortality following EVAR which remained unchanged.

Published
2022
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5. Fasting before living-kidney donation: effect on donor well-being and postoperative recovery: study protocol of a multicenter randomized controlled trial

Author

Oudmaijer, C. A. J., Minnee, R. C., Pol, R. A., van den Boogaard, W. M. C., Komninos, D. S. J., van de Wetering, J., van Heugten, M. H., Hoorn, E. J., Sanders, J. S. F., Hoeijmakers, J. H. J., Vermeij, W. P., IJzermans, J. N. M., Surgery, Internal Medicine, Molecular Genetics, Groningen Kidney Center (GKC), Groningen Institute for Organ Transplantation (GIOT), and ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE)

Subjects
Medicine (General), Postoperative recovery, Kidney Transplantation/adverse effects, Ischemia-reperfusion injury, Medicine (miscellaneous), Fasting, Kidney, Kidney Transplantation, Kidney/surgery, Study Protocol, R5-920, Living Donors, Quality of Life, Humans, Multicenter Studies as Topic, Pharmacology (medical), Living-kidney donation, Randomized Controlled Trials as Topic
Abstract

Background One of the main effectors on the quality of life of living-kidney donors is postoperative fatigue. Caloric restriction (CR) and short-term fasting (STF) are associated with improved fitness and increased resistance to acute stress. CR/STF increases the expression of cytoprotective genes, increases immunomodulation via increased anti-inflammatory cytokine production, and decreases the expression of pro-inflammatory markers. As such, nutritional preconditioning by CR or STF represents a non-invasive and cost-effective method that could mitigate the effects of acute surgery-induced stress and postoperative fatigue. To investigate whether preoperative STF contributes to a reduction in fatigue after living-kidney donation, a randomized clinical trial is indicated. Methods We aim to determine whether 2.5 days of fasting reduces postoperative fatigue score in subjects undergoing living-kidney donation. In this randomized study, the intervention group will follow a preoperative fasting regime for 2.5 days with a low-dose laxative, while the control group will receive standard care. The main study endpoint is postoperative fatigue, 4 weeks after living-kidney donation. Secondary endpoints include the effect of preoperative fasting on postoperative hospital admission time, the feasibility of STF, and the postoperative recovery of donor and recipient kidney function. This study will provide us with knowledge of the feasibility of STF and confirm its effect on postoperative recovery. Discussion Our study will provide clinically relevant information on the merits of caloric restriction for living-kidney donors and recipients. We expect to reduce the postoperative fatigue in living-kidney donors and improve the postoperative recovery of living-kidney recipients. It will provide evidence on the clinical merits and potential caveats of preoperative dietary interventions. Trial registration Netherlands Trial Register NL9262. EudraCT 2020-005445-16. MEC Erasmus MC MEC-2020-0778. CCMO NL74623.078.21

Published
2022
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6. Additional file 1 of Fasting before living-kidney donation: effect on donor well-being and postoperative recovery: study protocol of a multicenter randomized controlled trial

Author

Oudmaijer, C. A. J., Minnee, R. C., Pol, R. A., van den Boogaard, W. M. C., Komninos, D. S. J., van de Wetering, J., van Heugten, M. H., Hoorn, E. J., Sanders, J. S. F., Hoeijmakers, J. H. J., Vermeij, W. P., and IJzermans, J. N. M.

Abstract

Additional file 1:. Figures and biological specimens.

Published
2022
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7. Additional file 2 of Fasting before living-kidney donation: effect on donor well-being and postoperative recovery: study protocol of a multicenter randomized controlled trial

Author

Oudmaijer, C. A. J., Minnee, R. C., Pol, R. A., van den Boogaard, W. M. C., Komninos, D. S. J., van de Wetering, J., van Heugten, M. H., Hoorn, E. J., Sanders, J. S. F., Hoeijmakers, J. H. J., Vermeij, W. P., and IJzermans, J. N. M.

Abstract

Additional file 2:. Informed consent forms.

Published
2022
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9. A National Programmable Infrastructure to Experiment with Next-Generation Networks

Author

Grosso, P., Hesselman, C., Hendriks, L., Hill, J., Konstantaras, S., van der Pol, R., Reijs, V., de Ruiter, J., Schutijser, C., Ahmed, T., Festor, O., Ghamri-Doudane, Y., Kang, J.-M., Schaeffer-Filho, A.E., Lahmadi, A., Madeira, E., and Multiscale Networked Systems (IvI, FNWI)

Abstract

We have set up the first multi-domain P4programmable network in the Netherlands, consisting of six different sites interconnected by SURF's optical network. The purpose of the network is to experiment with novel inter-domain network functions and emerging internet architectures, in particular to improve the transparency, accountability, and controllability of the Internet and future networks. We provide an overview of the testbed's set-up, examples of how we have used it, and our lessons learned.

Published
2021

13. 18F-FDG UPTAKE IN VISCERAL ADIPOSE TISSUE IS INVERSELY ASSOCIATED TO INSULIN RESISTANCE AND ADIPONECTIN

Author

Reijrink, M., Spoor, D. S., Antunes, I. Farinha, Greuter, M. J. W., Pol, R. A., Heerspink, H. J. Lambers, Hillebrands, J. L., Slart, R. H. J. A., Mulder, D. J., Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Cardiovascular Centre (CVC), Translational Immunology Groningen (TRIGR), and ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE)

Published
2019

14. Economic Impact of Etanercept in Patients with Psoriasis and Psoriatic Arthritis in Spain: A Systematic Review

Author

Puig, L, Fernandez-Freire, LR, Burgos-Pol, R, Gomez, I, Peral, C, Gomez, S, and Laserna, FJR

Subjects
Economic evaluations, Spain, Psoriatic arthritis, Systematic review, Psoriasis, Etanercept
Abstract

Introduction Etanercept (ETN), a highly effective biological agent for the treatment of psoriasis (PSO) and psoriatic arthritis (PsA), is widely used in Spain. However, evidence of its economic impact is limited, indicating the need for a systematic review of the economic assessments conducted on the use of ETN in the treatment of both PSO and PsA in Spain. Methods A systematic review was carried out in PubMed, Embase, Cochrane Library, Health Technology Assessment reports and not indexed sources up to November 2018. The inclusion criteria were economic evaluations (total and partial) and dose optimization studies published in English or Spanish on the use of ETN to treat PSO and PsA for ETN in Spain. Results A total of 402 publications were identified, of which 32 were selected for inclusion in the review; of these 32 publications, 81.3% analyzed PSO (14 full economic evaluations, 5 partial economic evaluations and 7 dose optimization studies) and 18.8% analyzed PsA (1 economic analysis and 5 dose optimization studies). The perspective of the Spanish National Health Service (NHS) was used in 90.0% (n = 18) of the full and partial economic evaluations. The time horizons ranged from 12 weeks to 2 years. Reductions in the Psoriasis Area and Severity Index (PASI) of 50, 75 and 90% (PASI 50, 75 and 90, respectively) were most commonly used as efficacy outcomes in the complete evaluations. The economic impact of ETN ranged from euro9110-14,337/PASI 75 at 12 weeks (50 mg/week) to euro82,279/PASI 90 at 2 years, depending on the health outcome, time horizon and ETN dose used. Only one study determined the cost of using ETN for the treatment of PSO (euro29,430-52,367/QALY for dose 2 x 25 mg/week or 50 mg/week, respectively). Only one partial economic evaluation on PSA was identified (NHS perspective), resulting in an ETN annual cost of euro8585/patient-year. Conclusion Consistent evidence on the economic impact of ETN for the treatment of PSO and PSA in Spain is lacking, mainly due to the highly heterogeneous methodology used and the broad range of outcomes found in the economic evaluations published to date. Funding Pfizer S.L.U.

Published
2019

15. Treatment of symptomatic oral mucositis with sodium hyaluronate and synthetic amino acid precursors of collagen in patients undergoing haematopoietic stem cell transplantation

Author

TIZIANA RUGGIERO, Pol R, Camisassa D, Simiele S, Giaccone L, and Carossa S

Subjects
Adult, Male, Stomatitis, Hematopoietic Stem Cell Transplantation, Middle Aged, Allografts, Aged, Amino Acids, Female, Humans, Hyaluronic Acid, Collagen, Oral Sprays
Abstract

The purpose of the study is to evaluate the clinical effects of Mucosamin® (a spray preparation containing sodium hyaluronate combined with a pool of amino acids of precursor collagen, including L-Proline, L-Leucine, L-Lysine and glycine) on wound healing and pain management of oral mucositis after hematopoietic stem cell transplantation. The importance of professional dental hygiene by dental hygienist in reducing the severity of oral mucositis as unique therapy or in addition to therapy with Mucosamin® was also evaluated. One hundred thirty-seven patients undergoing hematopoietic stem cell transplantation were recruited in a case-control study and divided into 4 groups: Group A: professional oral hygiene + Mucosamin®; Group B: professional oral hygiene + standard treatment with chlorhexidine 0.20%;; Group C: only Mucosamin®; Group D: only standard treatment with chlorhexidine 0.20%. The following evaluations were made: WHO mucositis scale, OMAS mucositis scale, VAS, periodontal recording, days of mucositis. Comparing the groups at the onset of OM on WHO scale, it was observed that Group A grade 1 occurrence was more statistically significant than Group B (p= 0.03*); comparison between Group A and D showed a statistically significant difference in favour of Group A (p= 0.0002*). Also OMAS scale showed a statistically significant difference between groups who assumed Mucosamin, who developed lower OM grade (p = 0.001*). There was a statistically significant difference between group A compared with group B over the overall duration of OM (p = 0.02*), as well as between group A and group D (p=0.03*). According to the present study the combination of a careful debridement, correct oral hygiene during hospitalization and the use of Mucosamin® exponentially reduces the severity and duration of mucositis and consequently the discomfort of the patient. Moreover, it can be stated that the use of Mucosamin® also results in a reduction in the extent of chemotherapy lesions. Hyaluronic acid and amino acid-based sprays can be a valuable therapeutic aid in the treatment of mucositis.

Published
2018

16. Das Tier als 'politischer Mensch' in den Frontispizen einiger Principe-Übersetzungen

Author

Paravicini Bagliani, A., Mordeglia, Caterina, Dionigi, IVANO 20021948, Fedeli, P., Alvarez, M. C., Iglesias, R. M., Santi, F., De Pol, R., Dandre, P., Di Ricco, A., Padano, G., Bartezzaghi, S., Giradi, E., Pallottino, Paola, Orlando, A., Martini, M., Tortarolo, R., and Fossati, Ivano

Subjects
Francia, animali, traduzioni, Machiavelli, Olanda, Francia, Langenhert, Ghys, Olanda, Machiavelli, Ghys, animali, traduzioni, Langenhert
Published
2017

17. Ex vivo 18F-NaF uptake by carotid plaques on microPET/CT does not differ between symptomatic and asymptomatic patients and is common in renal arteries from healthy kidney donors

Author

Hop, H., De Boer, S. A., Reijrink, M., Doorenbos, C. S. E., Kamphuisen, P. W., De Borst, M. H., Pol, R. A., Zeebregts, C. J., Slart, R. H. J. A., Boersma, H. H., Mulder, D. J., Cardiovascular Centre (CVC), Vascular Ageing Programme (VAP), Groningen Kidney Center (GKC), Lifestyle Medicine (LM), Groningen Institute for Organ Transplantation (GIOT), Man, Biomaterials and Microbes (MBM), Translational Immunology Groningen (TRIGR), and ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE)

Published
2016

19. Metabolic Engineering toward Sustainable Production of Nylon-6

Author

Turk, S.C.H.J., Kloosterman, W.P., Ninaber, D.K., Kolen, K.P.A.M., Knutova, J., Suir, E., Schurmann, M., Raemakers-Franken, P.C., Muller, M., Wildeman, S.M.A. de, Raamsdonk, L.M., Pol, R. van der, Wu, L., Temudo, M.F., Hoeven, R.A.M. van der, Akeroyd, M., Stoel, R.E. van der, Noorman, H.J., Bovenberg, R.A.L., and Trefzer, A.C.

Subjects
adipate, alpha-ketopimelate, metabolic engineering, 6-aminocaproic acid, caprolactam, nylon-6
Published
2016

20. The Cost of Psoriasis and Psoriatic Arthritis in 5 European Countries: A Systematic Review

Author

Burgos-Pol R, Martínez-Sesmero JM, Ventura-Cerdá JM, Elías I, Caloto MT, and Casado MÁ

Subjects
Cost of Illness, Italy, Spain, Germany, Arthritis, Psoriatic, Humans, Psoriasis, France, health care economics and organizations, United Kingdom
Abstract

Introduction: While the introduction of biologics has improved the quality of life of patients with psoriasis and psoriatic arthritis, it may have increased the economic burden of these diseases. Objective: To perform a systematic review of studies on the costs associated with managing and treating psoriasis and psoriatic arthritis in 5 European countries: Germany, Spain, France, Italy, and the United Kingdom. Methods: We undertook a systematic review of the literature (up to May 2015) using the MEDLINE and EMBASE databases. The methodological quality of the studies identified was evaluated using the Consolidated Health Economic Evaluation Reporting Standards checklist. We considered both direct costs (medical and nonmedical) and indirect costs, adjusted for country-specific inflation and converted to international dollars using purchasing power parity exchange rates for 2015 ($US PPP). Results: The search retrieved 775 studies; 68.3% analyzed psoriasis and 31.7% analyzed psoriatic arthritis. The total annual cost per patient ranged from US $2,077 to US $13,132 PPP for psoriasis and from US $10,924 to US $17,050 PPP for psoriatic arthritis. Direct costs were the largest component of total expenditure in both diseases. The severity of these diseases was associated with higher costs. The introduction of biologics led to a 3-fold to 5-fold increase in direct costs, and consequently to an increase in total costs. Conclusions: We have analyzed the economic burden of psoriasis and psoriatic arthritis and shown that costs increase with the treatment and management of more severe disease and the use of biologics. (C) 2016 AEDV. Published by Elsevier Espana, S.L.U. All rights reserved.

Published
2016

21. Use of sodium hyaluronate and synthetic amino acid precursors of collagen for the symptomatic treatment of mucositis in patients undergoing haematopoietic stem cell transplants

Author

TIZIANA RUGGIERO, Pol R, Camisassa D, Arata V, Martino I, Giaccone L, and Carossa S

Subjects
Adult, Aerosols, Male, Stomatitis, Transplantation Conditioning, Chlorhexidine, Hematopoietic Stem Cell Transplantation, Mouthwashes, Middle Aged, Oral Hygiene, Combined Modality Therapy, Young Adult, Humans, Female, Collagen, Amino Acids, Hyaluronic Acid, Aged
Abstract

Oral mucositis (OM) may occur in up to 100% of patients undergoing condition regimen to hematopoietic stem cell transplant (HSCT). From the patient’s perspective, OM is one of the most debilitating side effects of transplantation. It is commonly thought that oral hygiene can modify the incidence and severity of oral mucositis, therefore professional oral health care (POHC) is recommended prior to conditioning regimen for HSCT. A new strategy for the treatment of OM is sodium hyaluronate (SH) combined with amino acid precursors of collagen (Aas) (Mucosamin®). SH is a mucoaderent polymer acting as a mechanical barrier and pain reliever. Furthermore, it allows prolonged contact of the product with the mucous membrane. In this study, a total of 68 adult patients due to undergo HSCT for allogenic and autologous transplant were enrolled at the Stem Cell Transplant Unit. The patients were divided into two groups. One group was treated with POHC before HSCT and applications of Mucosamin® during the recovery after transplantation. The second group served as controls, with the usual treatment of Clorexidine 0.20% adopted by the department. After HSCT the same clinician, an expert in oral medicine trained for the clinical trial, evaluated symptoms of the patients’ mucositis of both groups every day. The treated patients developed less severe OM, therefore Mucosamin® seems to have a protective role against the more severe phases of mucositis. The maximum OM pain, measured with the VAS scale, was higher in patients who did not use Mucosamin®. In the treated group OM resolved sooner than in the control group.

Published
2016

22. Creating a Worldwide Network For the Global Environment for Network Innovations (GENI) and Related Experimental Environments

Author

Mambretti, J., Chen, J., Yeh, F., Ge, J., You, J., Li, T., de Laat, C., Grosso, P., Liu, T.-L., Luo, M.-Y., Nakao, A., Müller, P., van der Pol, R., Reed, M., Stanton, M., Yang, C.-S., McGeer, R., Berman, M., Elliott, C., Ricci, R., System and Network Engineering (IVI, FNWI), and IvI Research (FNWI)

Subjects
Network architecture, Scope (project management), business.industry, Computer science, Scale (chemistry), Information technology, 020206 networking & telecommunications, 02 engineering and technology, 021001 nanoscience & nanotechnology, Virtualization, computer.software_genre, Data science, Information-centric networking, 0202 electrical engineering, electronic engineering, information engineering, Macro, 0210 nano-technology, business, computer, Global environmental analysis
Abstract

Many important societal activities are global in scope, and as these activities continually expand world-wide, they are increasingly based on a foundation of advanced communication services and underlying innovative network architecture, technology, and core infrastructure. To continue progress in these areas, research activities cannot be limited to campus labs and small local testbeds or even to national testbeds. Researchers must be able to explore concepts at scale—to conduct experiments on world-wide testbeds that approximate the attributes of the real world. Today, it is possible to take advantage of several macro information technology trends, especially virtualization and capabilities for programming technology resources at a highly granulated level, to design, implement and operate network research environments at a global scale. GENI is developing such an environment, as are research communities in a number of other countries. Recently, these communities have not only been investigating techniques for federating these research environments across multiple domains, but they have also been demonstration prototypes of such federations. This chapter provides an overview of key topics and experimental activities related to GENI international networking and to related projects throughout the world.

Published
2016

23. Low mean impedance in 24-hour tracings and esophagitis in children: a strong connection

Author

Silvia Salvatore, Salvatoni A, Ummarino D, Ghanma A, Van der Pol R, Rongen A, Fuoti M, Meneghin F, Ma, Benninga, Vandenplas Y, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Paediatric Gastroenterology, and Growth and Development

Subjects
Male, Esophageal pH Monitoring, esophageal impedance, Statistics as Topic, Infant, Reproducibility of Results, Hydrogen-Ion Concentration, Esophagus, Child, Preschool, Electric Impedance, Gastroesophageal Reflux, Humans, Female, Esophagoscopy, endoscopy, Children, Esophagitis, Peptic
Abstract

Esophageal multiple intraluminal impedance baseline is an additional impedance parameter that was recently related to esophageal integrity. The aim of this study was to assess the relationship between mean esophageal impedance value and endoscopic findings in a large group of children. Children with symptoms of gastroesophageal reflux submitted to both endoscopy and impedance were included. Esophagitis was graded according to the Los Angeles classification. Mean impedance value was automatically calculated over 24-hour tracings. Data were adjusted for age through z-score transformation using percentiles normalized by the LMS (Lambda for the skew, Mu for the median, and Sigma for the generalized coefficient of variation) method. Nonparametric Mann-Whitney and Kruskal-Wallis tests, multiple, and stepwise regression were used. P-value

Published
2016

25. Temi libertini fra Milano e Genova da Magnasco a Saccheri

Author

Beniscelli, A., Corradini, M., Cavarzere, M., De Pol, R., Bufacchi, E., Marini, Q., Fontana, P., Stagno, L., Magnani, L., ORLANDI BALZARI, Vittoria, Facchin, Laura, Franchini Guelfi, F., Spiriti, Andrea, and Arecco, D.

Subjects
Seicento - Libertinismo erudito - Pittura - Magnasco - Saccheri
Published
2014

26. Experiences with MPTCP in an intercontinental OpenFlow network

Author

Pol, R van der, Bredel, M, Barczyk, A, Overeinder, B, van Adrichem, N.L.M., Kuipers, F.A., and Foster et al, D

Subjects
OpenFlow, Big data, Multipath, MPTCP
Abstract

The size and amount of e-science data sets is growing rapidly. Keeping up with the network demand in order to transfer these data sets over the Internet is a challenge. Single links do not have enough capacity anymore. Therefore we need to install more interfaces in the servers and use all available paths in the network. In this paper we describe two new technologies that help to optimally use the capacity of all multiple paths simultaneously. OpenFlow is used to discover the topology of the network,calculate multiple paths and configure those paths on the OpenFlow network. Multipath TCP (MPTCP) is used on the servers to distribute the load across the paths. We describe the end-to-end good put measurements we did in our OpenFlow test bed. We show that we reach a much higher throughput with multiple paths compared to a single path.

Published
2013

28. Bolonia versus innovación

Author

Basante Pol, R.

Subjects
Estrategias de aprendizaje autónomo, Licenciado en farmacia, European Higher Education Area (EHEA), of autonomous learning, Europeo de Educación Superior (EEES), Bachelor in pharmacy
Abstract

El comienzo de la Licenciatura en Farmacia, en el entorno del EEES, exige un esfuerzo innovador. Los calificados docentes deben fomentar los aspectos básicos relacionados con la formación humanística, aspectos históricos, sociológicos, legislativos de la profesión farmacéutica. Por esta razón, también valor normativo español y europeo en relación con la Ley sanitarias. En este resumen, se analizan las principales dificultades de la enseñanza al aprendizaje. Además como la promoción de estrategias de aprendizaje de los estudiantes autónomos. Por esta razón, es necesario la nueva aplicación de nuevos métodos de enseñanza., The beginning of the Bachelor in Pharmacy, in the environment of EHEA, demands an innovative effort. The proffesors must foment the basic aspects related with the humanistic, historical, sociological aspects, legislatives of the pharmaceutical profession. For this reason, we will also value normative Spanish and European relative to sanitary Law. In this abstract, we analyze the main difficulties from the teaching to the learning. Besides as promoting strategies of the students' autonomous learning. For this reason it is necessary the new application of new methods of teaching.

Published
2010

30. Implantologia a carico immediato. Riabilitazioni totali

Author

Mozzati, M., Carossa, Stefano, Arata, V., Bassi, Francesco, Bianchi, L., Bianchi, Silvio Diego, Manzella, C., Pol, R., Previgliano, V., Schierano, Gianmario, Barone, M., and Burello, V.

Subjects
Implantologia, carico immediato, edentulia totale
Published
2010

31. Network description tools and standards

Author

Dijkstra, F., van der Ham, J., van der Pol, R., and System and Network Engineering (IVI, FNWI)

Abstract

Setting up high-speed network connections - light paths - is still a manual effort taking two to three weeks. The network engineers need a clear picture of the network topology in order to plan and configure light paths. The Network Markup Language (NML) standardizes network topology and state information. The University of Amsterdam and SARA Computing & Networking Services in the Netherlands are contributing to this effort, with the ultimate goal being to automatically set up and manage light paths.

Published
2009

33. Risk premiums in cap rates of investment property

Author

van Wouwe, Martine, Berkhout, Tom M., and Tansens, Pol R.

Subjects
Economics, health care economics and organizations
Abstract

This article reports the results of a study about the correlations and patterns over time between the composite elements of the initial yield in the prime office and retail property markets in the Netherlands, the United Kingdom (London), Belgium (Brussels), and Germany (Frankfurt). For this study, the determinant components are identified as the risk-free interest rate, inflation, and the risk premium. For the multiple regression analysis, these components are supplemented with dummy variables for property types and locations.

Published
2008

36. La guarigione delle ferite

Author

Cocero, N., Pol, R., and Zaffe, Davide

Subjects
guarigione delle ferite, tessuto osseo, alveolo postestrattivo, mucosa orale
Published
2008

38. Multifocal fibrosclerosis presenting as Grave's orbitopathy. Bilateral exophthalmos associated with retroperitoneal and sellar fibrosis

Author

van der Pol, R., Nieuwenhuis, M. G., Mourits, M. P., and Other departments

Abstract

BACKGROUND: Multifocal fibrosclerosis (MF) is a rare disease that may be misdiagnosed as Graves' orbitopathy. The combination of localisations of MF presented here has not been reported before. CASE REPORT: A 44-year-old man was referred with progressive bilateral exophthalmos. CT of his chest and abdomen revealed an intrathoracic and retroperitoneal peri-aortal soft-tissue process with hydronephrosis. Histological examination of orbital masses showed a fibrous process with low inflammatory activity. Later the sella was found to be involved as well. A diagnosis of MF was made. CONCLUSION: MF should be considered in the differential diagnosis of bilateral exophthalmos

Published
1999

40. Internationaler Entwicklungsstand und Tendenzen auf dem Gebiet computer-gestützter Entscheidungssysteme

Author

rer. pol. R. Herbold

Abstract

Ein amerikanischer Hersteller des Nahrungs- und Genu× mittel-Sektors spurte den Verbrauchsgewohnheiten der amerikanischen Familie nach und untersuchte Einkaufsmotive und Einkaufsverhalten der amerikanischen Hausfrauen. Der Grad der Freude oder Unlust am Kochen wurde ermittelt, auch die Rolle, die Fertiggerichte im Berufsleben der Hausfrau spielen, die Reaktionen der Konsumentinnen auf neue Produkte und auf die Art und Weise der Produktankundigung. Geographisch bedingte Verhaltensweisen wurden festgestellt, klimatisch und saisonale Besonderheiten und Einflusse gemessen. Daraus entstand das Modell der amerikanischen “Durchschnittshausfrau”. Das Modell, in Algorithmen gefa×t, wurde dann in das computer-gestutzte Management-Informationssystem der Unternehmung eingefugt.

Published
1971
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42. A High Abdominal Aortic Calcification Score by Dual X-Ray Absorptiometry (DXA) is Associated with Cardiovascular Events after Kidney Transplantation

Author

Benjamens, S., Pol, R. A., Glaudemans, A. W., Wieringa, I., Berger, S. P., Bakker, S. J., Slart, R. H., Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), Groningen Kidney Center (GKC), Cardiovascular Centre (CVC), Translational Immunology Groningen (TRIGR), and ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE)

44. The Value of Two Consecutive Post-Transplant Renal Scintigraphy Procedures. A Single-Center Retrospective analysis

Author

Benjamens, S., Aiko de Vries, Pol, R. A., Berger, S. P., Glaudemans, A. W. J. M., Dibbets-Schneider, P., Slart, R. H. J. A., Geus-Oei, L., Translational Immunology Groningen (TRIGR), Cardiovascular Centre (CVC), Groningen Institute for Organ Transplantation (GIOT), Groningen Kidney Center (GKC), and ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE)

45. New insights in (acute) endovascular abdominal aneurysm repair: when fenestrated devices fall short

Author

Pol, R. A., Tielliu, I. F. J., Zeebregts, C. J., Groningen Institute for Organ Transplantation (GIOT), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Man, Biomaterials and Microbes (MBM), and Vascular Ageing Programme (VAP)

Subjects
PATHOLOGIES, ARTERY ANEURYSM, ENDOGRAFTS, Aortic diseases, MULTILAYER STENT, Aneurysm, JUXTARENAL AORTIC-ANEURYSMS, surgical procedures, operative, ENDOLEAKS, cardiovascular system, EXPERIENCE, GRAFTS, cardiovascular diseases, FOLLOW-UP, Aorta
Abstract

The suitability for endovascular aneurysm repair (EVAR) is determined primarily by abdominal aortic aneurysm (AAA) anatomy. For patients unsuitable for standard EVAR, due to proximal neck anatomy, fenestrated aortic stent-grafting (FEVAR) is a viable alternative to open repair surgery. Initially FEVAR stent-grafts were custom-made to fit the unique anatomical characteristics of each treated individual. This customization leads to production delays therefore excluding acute aneurysms from endovascular treatment. For patients in need for more urgent treatment, several alternatives have currently been developed. The aim of this review is to provide an overview on current developments and results in acute endovascular abdominal aortic aneurysm repair.

46. Analisa Gula Kristal Putih Secara Cepat Menggunakan Near Infrared Spectroscopy

Author

Opal Priya Wening

Abstract

Near infrared spectroscopy (NIRS) merupakan metode alternatif untuk menganalisa parameter sampel yang lebih cepat. Pada penelitian ini, NIRS akan digunakan sebagai penentuan kualitas gula kristal putih (GKP) dengan parameter penting seperti pol, warna, susut pengeringan, dan berat jenis butiran. Sampel gula yang digunakan berasal dari laboratorium P3GI. Instrumen NIRS menggunakan FOSS XDS rapid content analysis , kemudian model yang dibangun menggunakan metode kalibrasi partial least square (PLS). Hasil NIRS dievaluasi dengan standar: nilai korelasi R 2 dan r 2 yang mendekati 1, error SEC yang rendah, dan rasio RPD yang tinggi. Penelitian menghasilkan nilai untuk pol (%): R 2 = 0,970, SEC = 0,023, r 2 = 0,496, RPD = 1,152; warna (IU): R 2 = 0,970, SEC = 12,305, r 2 = 0,757, RPD = 1,529; susut pengeringan (%): R 2 = 0,973, SEC = 0,004, r 2 = 0,789, RPD = 1,601; dan berat jenis butiran (mm): R 2 = 0,954, SEC = 0,038, r 2 = 0,407, RPD = 0,997. Berdasarkan hasil evaluasi tersebut metode NIRS berpotensi sebagai analisa kualitas gula kristal putih dengan model yang dibangun tergolong sebagai pendahuluan.

Published
2021
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47. Kejahatan Paham Radikalisme dan Aksi Terorisme Mengancam Keutuhan NKRI

Author

Vara Adiba

Abstract

Indonesia adalah negara yang memiliki berbagai macam suku,ras,agama,etnik,dan budaya.Sehingga saat kita mampu menerima perbedaan tersebut tidak akan memicu terjadinya tindakan radikalisme dan terorisme.Menurut Direktur Pencegahan BNPT Brigjen Pol R Ahmad Nurwakhid pada acara dialog Jaga Kampus Kita, yang berlngsung di Kampus UMI,Radikalisme adalah paham atau fase yang kemudian menuju terorisme. Radikalisme menjadi suatu hal yang dapat menghambat keutuhan suatu bangsa di mana ini sangat bertentangan dengan pancasila pada sila ke 3 “Persatuan Indonesia”,pertanyaannya adalah bagaimana upaya yang dilakukan pemerintah dan kita untuk memberikan pemahaman kepada masyarakat terkait bahaya radikalisme sehingga tidak melakukan suatu aksi yang disebut terorisme .Menurut Hartanto, D. A. (2017) upaya untuk mengurangi radikalisme dapat dilakukan oleh seluruh masyarakat Indonesia. Pemerintahnya juga harus terlibat membentengi masyarakat khususnya remaja untuk dibekali ilmu supaya tidak terpengaruh terhadap radikalisme.Tujuan dari pembentukan artikel ini adalah memberikan pemahaman pada masyarakat terkait bentuk-bentuk radikalisme,pentingnya memperluas pengetahuan dan memperdalam agama supaya tidak terjerumus ke dalam aksi-aksi yang berbau kekerasan sehingga tercipta Negara Kesatuan Republik Indonesia yang utuh dan bersatu sesuai dengan semboyan “Berbeda-beda tetapi tetap satu jua” dan Sila ke 3 Pancasila yang berbunyi Persatuan Indonesia.

Published
2022
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48. Brief irradiation with red or blue light induces orientational movement of chloroplasts in dark-adapted prothallial cells of the fernAdiantum

Author

Takatoshi Kagawa and Masamitsu Wada

Subjects
Chloroplast, Dark-adapted, Phytochrome, Plant biochemistry, Botany, Biophysics, Plant Science, Irradiation, Red light, Biology, Blue light
Abstract

Orientational movement of chloroplasts was induced by a brief irradiation with red light (R) or blue light (B) in dark-adapted prothallial cells ofAdiantum, whose chloroplasts had gathered along the cell dividing wall (i.e., the anticlinal wall). When the whole dark-adapted prothallia were irradiated from a horizontal direction (i.e., from their lobes) with horizontally vibrating polarized R (H pol. R) for 10 or 3 min, the chloroplast left the anticlinal walls and spread over the prothallial surface (i.e., the periclinal walls) within 1–2 hr after the onset of irradiation, returning to the anticlinal wall (dark-position) within 10 hr. However, vertically vibrating polarized R (V pol. R) for 10 min did not induce the movement towards periclinal walls. The R effect was cancelled by non-polarized far-red light (FR) irradiation just after the R irradiation. Irradiation with H pol. B for 10 or 3 min but not with V pol. B could also induce a similar movement of chloroplasts, although the chloroplasts returned within 4 hr. The effect of H pol. B, however, was not cancelled by the subsequent FR irradiation.

Published
1994
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49. Eksaktie automodulārie atrisinājumi hidrodinamikā un magnētiskajā hidrodinamikā un to attiecība pret uzdevumiem robežslāņa tuvinājumā

Author

Vladislavs Kremeņeckis and Fizikas un matemātikas fakultāte

Subjects
Fizika, materiālzinātne, matemātika un statistika, Fizika, Fizika, astronomija un mehānika
Abstract

ANOT��CIJA Disert��cija ir velt��ta prec��zo stacion��ro hidrodinamikas un magn��tiskas hidrodinamikas automodul��ro risin��jumu konstru��šanas vienotas pieejas izveidošanas iesp��ju p��t��šanai, k�� ar�� prec��zu risin��jumu un risin��jumu robežsl����a tuvin��jum�� sakar��b��m. Apskat��tas 4 visvair��k lietot��s koordin��tu sist��mas: Dekarta, pol��r�� (cilindrisk��s sist��mas speci��ls gad��jums, ko pie��emts apskat��t k�� patst��v��gu koordin��tu sist��mu), cilindrisk�� un sf��risk�� (divas p��d��j��s tiek apskat��tas aksi��li simetrisk�� variant��). P��t��šanas princips ir š��ds: tiek mekl��tas str��vas funkcijas, kuras ��autu p��rveidot parci��los diferenci��lvien��dojumus parastajos diferenci��lvien��dojumos, kuri p��c tam tiek ar�� atrasti. Robežnosac��jumi netiek apskat��ti, jo tie neietekm�� vien��dojumu ieg��šanu. Magn��tohidrodinamisko pl��smu gad��jum�� tiek apskat��ti k�� pilnie vien��dojumi, t�� ar�� vien��dojumi bezindukcijas tuvin��jum��, kad netiek ��emti v��r�� induc��tie magn��tiskie lauki. K�� piem��ri ir apskat��ti modific��ti klasiskie hidrodinamikas un magn��tohidrodinamikas uzdevumi. Darbs uzrakst��ts krievu valod��, sast��v no ievada, 5 noda����m un sl��dzieniem, 182 lappuses, 30 z��m��jumi. Literat��ras saraksta 73 nosaukumi. Darbs uzrakst��ts ar LZP un ESF grantu da����ju atbalstu. 4ANOT��CIJA Disert��cija ir velt��ta prec��zo stacion��ro hidrodinamikas un magn��tiskas hidrodinamikas automodul��ro risin��jumu konstru��šanas vienotas pieejas izveidošanas iesp��ju p��t��šanai, k�� ar�� prec��zu risin��jumu un risin��jumu robežsl����a tuvin��jum�� sakar��b��m. Apskat��tas 4 visvair��k lietot��s koordin��tu sist��mas: Dekarta, pol��r�� (cilindrisk��s sist��mas speci��ls gad��jums, ko pie��emts apskat��t k�� patst��v��gu koordin��tu sist��mu), cilindrisk�� un sf��risk�� (divas p��d��j��s tiek apskat�&#, SUMMARY The thesis is concerned with the study of a possibility to find a common approach to self-similar solutions of exact stationary equations of hydrodynamics and magnetohydrodynamics and a relationship between the exact solutions and the boundary layer solutions. The thesis considers four the most used systems of coordinates: a Cartesian system, a polar one (a particular case of the cylindrical coordinate system, which is usually considered as a self coordinate system), a cylindrical and a spherical systems (the latter two are considered as axially symmetric). The method of investigation is the search for stream functions allowing to transform the equations with partial derivatives into ordinary equations with the following derivation of equations themselves. Boundary conditions are not considered as they do not affect the equation derivation. For the magnetohydrodynamic flows, full equations are considered, where no suppositions about electromagnetic magnitudes are given, as well as equations in the non-inductive approximation, when induced magnetic fields are ignored. As examples, some modifications of classical problems of hydrodynamics and magnetohydrodynamics are considered. The thesis is written in Russian and consists of Introduction, 5 Sections and Conclusion. The total number of pages is 182 including 30 figures and 73 references. This dissertation is written under the partial support of LZP and ESF.

Published
2009

50. Association between Masseter Muscle Area and Thickness and Outcome after Carotid Endarterectomy: A Retrospective Cohort Study

Author

Rianne N. M. Hogenbirk, Louise B. D. Banning, Anita Visser, Harriet Jager-Wittenaar, Robert A. Pol, Clark J. Zeebregts, Joost M. Klaase, Personalized Healthcare Technology (PHT), Groningen Kidney Center (GKC), Groningen Institute for Organ Transplantation (GIOT), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Man, Biomaterials and Microbes (MBM), Value, Affordability and Sustainability (VALUE), and Clinical chemistry

Subjects
carotid endarterectomy, computed tomography, frailty, masseter muscle, risk management, sarcopenia, General Medicine
Abstract

Low muscle mass is associated with adverse outcomes after surgery. This study examined whether facial muscles, such as the masseter muscle, could be used as a proxy for generalized low muscle mass and could be associated with deviant outcomes after carotid endarterectomy (CEA). As a part of the Vascular Ageing study, patients with an available preoperative CT-scan, who underwent an elective CEA between December 2009 and May 2018, were included. Bilateral masseter muscle area and thickness were measured on preoperative CT scans. A masseter muscle area or thickness of one standard deviation below the sex-based mean was considered low masseter muscle area (LMA) or low masseter muscle thickness (LMT). Of the 123 included patients (73.3% men; mean age 68 (9.7) years), 22 (17.9%) patients had LMA, and 18 (14.6%) patients had LMT. A total of 41 (33.3%) patients had a complicated postoperative course and median length of hospital stay was four (4–5) days. Recurrent stroke within 5 years occurred in eight (6.6%) patients. Univariable analysis showed an association between LMA, complications and prolonged hospital stay. LMT was associated with a prolonged hospital stay (OR 8.78 [1.15–66.85]; p = 0.036) and recurrent stroke within 5 years (HR 12.40 [1.83–84.09]; p = 0.010) in multivariable logistic regression analysis. Masseter muscle might be useful in preoperative risk assessment for adverse short- and long-term postoperative outcomes.

Published
2022
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