10 results on '"Pierini, E"'
Search Results
2. Apparecchiatura per misurare la quantità di idrocarburi volatili presenti nell’aria
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Dori, L., Nicoletti, S., Cardinali, G. C., Elmi, I., Zampolli, S., Guerri, S., Zani, A., Corticelli, F., Mastrogiacomo, ANNA RITA, Pierini, E., Negrini, P., Pizzocchero, G., Sampaolo, L., and Tamarri, F.
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- 2003
3. Health effects of iron-ore mining (abstract)
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Sartorelli, E, Battista, Giuseppe, Bianchi, L, Strambi, F, Quercia, A, Comba, P, Belli, S, and Pierini, E.
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- 1984
4. A gas chromatographic-like system for the separation and monitoring of benzene, toluene and xylene compounds at the ppb level using solid state metal oxide gas sensors
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Dori, L., Nicoletti, S., Ivan Elmi, Mastrogiacomo, A. R., Sampaolo, L., and Pierini, E.
5. Balancing Benefits and Harms of COVID-19 Vaccines: Lessons from the Ongoing Mass Vaccination Campaign in Lombardy, Italy
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Giovanni Corrao, Federico Rea, Matteo Franchi, Danilo Cereda, Antonio Barone, Catia Rosanna Borriello, Giulia Petra Della Valle, Michele Ercolanoni, Jose Jara, Giuseppe Preziosi, Manuel Maffeo, Francesco Mazziotta, Elisabetta Pierini, Francesco Lecis, Pierfrancesco Sanchirico, Francesco Vignali, Olivia Leoni, Ida Fortino, Massimo Galli, Giovanni Pavesi, Guido Bertolaso, Corrao, G, Rea, F, Franchi, M, Cereda, D, Barone, A, Borriello, C, Della Valle, G, Ercolanoni, M, Jara, J, Preziosi, G, Maffeo, M, Mazziotta, F, Pierini, E, Lecis, F, Sanchirico, P, Vignali, F, Leoni, O, Fortino, I, Galli, M, Pavesi, G, and Bertolaso, G
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Pharmacology ,Infectious Diseases ,venous thromboembolism ,Drug Discovery ,Immunology ,COVID-19 ,Pharmacology (medical) ,healthcare utilization database ,effectiveness ,effectivene - Abstract
Background. Limited evidence exists on the balance between the benefits and harms of the COVID-19 vaccines. The aim of this study is to compare the benefits and safety of mRNA-based (Pfizer-BioNTech and Moderna) and adenovirus-vectored (Oxford-AstraZeneca) vaccines in subpopulations defined by age and sex. Methods. All citizens who are newly vaccinated from 27 December 2020 to 3 May 2021 are matched to unvaccinated controls according to age, sex, and vaccination date. Study outcomes include the events that are expected to be avoided by vaccination (i.e., hospitalization and death from COVID-19) and those that might be increased after vaccine inoculation (i.e., venous thromboembolism). The incidence rate ratios (IRR) of vaccinated and unvaccinated citizens are separately estimated within strata of sex, age category and vaccine type. When suitable, number needed to treat (NNT) and number needed to harm (NNH) are calculated to evaluate the balance between the benefits and harm of vaccines within each sex and age category. Results. In total, 2,351,883 citizens are included because they received at least one dose of vaccine (755,557 Oxford-AstraZeneca and 1,596,326 Pfizer/Moderna). A reduced incidence of COVID-19-related outcomes is observed with a lowered incidence rate ranging from 55% to 89% and NNT values ranging from 296 to 3977. Evidence of an augmented incidence of harm-related outcomes is observed only for women aged
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- 2022
6. Protective action of natural and induced immunization against the occurrence of delta or alpha variants of SARS-CoV-2 infection: a test-negative case-control study
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Giovanni Corrao, Matteo Franchi, Federico Rea, Danilo Cereda, Antonio Barone, Catia Rosanna Borriello, Petra Giulia Della Valle, Michele Ercolanoni, Ida Fortino, Jose Jara, Olivia Leoni, Francesco Mazziotta, Elisabetta Pierini, Giuseppe Preziosi, Marcello Tirani, Massimo Galli, Guido Bertolaso, Giovanni Pavesi, Francesco Bortolan, Corrao, G, Franchi, M, Rea, F, Cereda, D, Barone, A, Borriello, C, Della Valle, P, Ercolanoni, M, Fortino, I, Jara, J, Leoni, O, Mazziotta, F, Pierini, E, Preziosi, G, Tirani, M, Galli, M, Bertolaso, G, Pavesi, G, and Bortolan, F
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SARS-CoV-2 variants ,Public health ,COVID-19 Vaccines ,SARS-CoV-2 ,Case-Control Studies ,Vaccination ,COVID-19 ,Humans ,Medicine ,Immunization ,General Medicine ,SARS-CoV-2 variant - Abstract
Abstract Background The evolution of SARS-CoV-2 has led to the emergence of several new variants, and few data are available on the impact of vaccination on SARS-CoV-2 variants. We aimed to assess the association between natural (previous infection) and induced (partial or complete vaccination) exposure to SARS-CoV-2 and the onset of new infection supported by the delta variant, and of comparing it with that supported by alpha. Methods We performed a test-negative case-control study, by linking population-based registries of confirmed diagnoses of infection with SARS-CoV-2, vaccinations against Covid-19 and healthcare utilization databases of the Italian Lombardy Region. Four hundred ninety-six persons who between 27 December 2020 and 16 July 2021 had an infection by the delta variant were 1:1 matched with citizens affected by alphavariant and 1:10 matched with persons who had a negative molecular test, according to gender, age and date of molecular ascertainment. We used a conditional logistic regression for estimating relative risk reduction of either variants associated with natural and/or induced immunization and corresponding 95% confidence interval (CI). Results Previous infection was associated with 91% (95% CI 85% to 95%) reduced relative risk of reinfection, without evidence of significant differences between delta and alpha cases (p=0.547). Significant lower vaccinal protection against delta than alpha variant infection was observed with reduced relative risk associated with partial vaccination respectively of 29% (7% to 45%), and 62% (48% to 71%) (p=0.001), and with complete vaccination respectively of 75% (66% to 82%) and 90% (85% to 94%) (p=0.003). Conclusions Lower protection towards infections caused by the delta variant with respect to alpha variant was noticed, even after the completion of the vaccination cycle. This finding would support efforts to maximize both vaccine uptake with two doses and fulfilment with individual protection measures, especially as the delta variant is rampant worldwide presently.
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- 2022
7. Rapid, hydrolysis-free, dilute-and-shoot method for the determination of buprenorphine, norbuprenorphine and their glucuronides in urine samples using UHPLC-MS/MS
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Caterina Renzoni, Maurizio Piergiovanni, Giorgio Famiglini, Achille Cappiello, Marco Agostini, Veronica Termopoli, Pierangela Palma, Elisabetta Pierini, Agostini, M, Renzoni, C, Pierini, E, Piergiovanni, M, Termopoli, V, Famiglini, G, Palma, P, and Cappiello, A
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Adult ,Male ,Analyte ,Formic acid ,Clinical Biochemistry ,Pharmaceutical Science ,Urine ,Mass spectrometry ,01 natural sciences ,Analytical Chemistry ,chemistry.chemical_compound ,Glucuronides ,CHIM/01 - CHIMICA ANALITICA ,Limit of Detection ,Tandem Mass Spectrometry ,Drug Discovery ,medicine ,Humans ,Norbuprenorphine ,Chromatography, High Pressure Liquid ,Spectroscopy ,Chromatography ,010405 organic chemistry ,010401 analytical chemistry ,Reproducibility of Results ,Repeatability ,Middle Aged ,Reference Standards ,Buprenorphine ,0104 chemical sciences ,Analgesics, Opioid ,chemistry ,UHPLC-MS/MS, Buprenorphine ,Female ,Drug Monitoring ,Glucuronide ,medicine.drug - Abstract
Buprenorphine and its metabolites are routinely monitored to assess patient compliance with drug detoxification programs or as pain killers. A rapid method for the simultaneous analysis of buprenorphine, norbuprenorphine, and glucuronides in urine using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) was developed. Urine samples were diluted in water containing formic acid 0.1% and directly injected into the UHPLC-MS/MS system without any sample pretreatment. Quality control (QC) samples, prepared using 20 different urine matrices, fortified at 3 concentration levels, were quantified using four deuterated internal standards. The accuracy values obtained spanned from 90 to 114% with repeatability lower than 10% also in the inter-day between batch experiments. Matrix effects (ME), evaluated before correction with internal standards using Matuszewski procedure, mainly affected the analysis of buprenorphine glucuronide. The use of deuterated internal standards (IS) for each analyte was necessary to compensate for ME and was essential in the determination of glucuronides. The method was applied to 30 real urine samples from patients under a detoxification therapy. Duplicate analyses were performed with the presented method and compared with another method which involves a standard hydrolysis procedure. Real sample results were compared showing a good performance agreement, with differences between the two methods lower than ±20% in the quantification results.
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- 2019
8. Direct‐EI in LC–MS: Towards a universal detector for small‐molecule applications
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Pierangela Palma, Helga Trufelli, Veronica Termopoli, Giorgio Famiglini, Elisabetta Pierini, Achille Cappiello, Cappiello, A, Famiglini, G, Palma, P, Pierini, E, Termopoli, V, and Trufelli, H
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Spectrum analyzer ,Chemical noise ,Chemistry ,Detector ,Analytical chemistry ,Condensed Matter Physics ,Mass spectrometry ,Small molecule ,General Biochemistry, Genetics and Molecular Biology ,LC-MS ,Analytical Chemistry ,CHIM/01 - CHIMICA ANALITICA ,Liquid chromatography–mass spectrometry ,Ionization ,Electron ionization ,Nano-HPLC ,Direct-EI interface ,Matrix effect ,Spectroscopy - Abstract
DiSTeVA, Universita` degli Studi di Urbino ‘‘Carlo Bo,’’Piazza Rinascimento, 6, 61029 Urbino, ItalyReceived 13 July 2010; received (revised) 22 November 2010; accepted 22 November 2010Published online 8 March 2011 in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/mas.20329This review article will give an up-to-date and exhaustiveoverview on the efficient use of electron ionization (EI) tocouple liquid chromatography and mass spectrometry (LC–MS) with an innovative interface called Direct-EI. EI is basedon thegas-phase ionization of the analytes, and it is suitable formany applications in a wide range of LC-amenable compounds.In addition, thanks to its operating principles, it preventsunwelcome matrix effects (ME). In fact, although atmosphericpressure ionization (API) methodologies have boosted the use ofLC–MS, the related analytical methods are sometime affectedby inaccurate quantitative results, due to unavoidable andunpredictable ME. In addition, API’s soft ionization spectraalways demand for costly and complex tandem mass spectrom-etry (MS/MS) instruments, which are essential to acquire an‘‘information-rich’’ spectrum and to obtain accurate quantita-tive information. In EI a one-stage analyzer is sufficient for aqualitative investigation and MS/MS detection is only used toimprove sensitivity and to cut chemical noise. The technologyillustrated here provides a robust and straightforward accessto classical, well-characterized EI data for a variety ofLC applications, and readily interpretable spectra for a widerange of areas of research. The Direct-EI interface canrepresent the basis for a forthcoming universal LC–MSdetector for small molecules. # 2011 Wiley Periodicals, Inc.,Mass Spec Rev 30:1242–1255, 2011Keywords: LC–MS; nano-HPLC; electron ionization; Direct-EI interface; matrix effects
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- 2011
9. Electron Ionization in LC-MS: Recent Developments and Applications of the Direct-EI LC-MS Interface
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Helga Trufelli, Giorgio Famiglini, Elisabetta Pierini, Achille Cappiello, Veronica Termopoli, Pierangela Palma, Palma, P, Famiglini, G, Trufelli, H, Pierini, E, Termopoli, V, and Cappiello, A
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Chemistry ,business.industry ,Interface (computing) ,Analytical chemistry ,Automatic processing ,Mass spectrometry ,Biochemistry ,LC-MS, LEI ,Analytical Chemistry ,Matrix (chemical analysis) ,CHIM/01 - CHIMICA ANALITICA ,Liquid chromatography–mass spectrometry ,Interfacing ,Ionization ,Process engineering ,business ,Electron ionization - Abstract
The purpose of this article is to underline the possibility of efficiently using electron ionization (EI) in liquid chromatography (LC) and mass spectrometry (MS). From a historical perspective, EI accompanied the first attempts in LC-MS but, owing to several technical shortcomings, it was soon outshined by soft, atmospheric pressure ionization (API) techniques. Nowadays, two modern approaches, supersonic molecular beam LC-MS and direct-EI LC-MS, offer a valid alterative to API, and preserve the advantages of EI also in LC-MS applications. These advantages can be summarized in three crucial aspects: automated library identification; identification of unknown compounds, owing to EI extensive fragment information; inertness to coeluted matrix interferences owing to very unlikely ion–ion and ion–molecule interactions in the EI gas-phase environment. The direct-EI LC-MS interface is a simple and efficient solution able to produce high-quality, interpretable EI spectra from a wide range of low molecular weight molecules of different polarity. Because of the low operative flow rates, this interface relies on a nano-LC technology that helps in reducing the impact of the mobile phase on the gas-phase environment of EI. This review provides an extensive discussion on the role of EI in LC-MS interfacing, and presents in detail several performance aspects of the direct-EI LC-MS interface, especially in terms of response, mass-spectral quality, and matrix effects. In addition, several key applications are also reported.
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- 2011
10. Overcoming matrix effects in liquid chromatography-mass spectrometry
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Elisabetta Pierini, Helga Trufelli, Veronica Termopoli, Achille Cappiello, Pierangela Palma, Giorgio Famiglini, Cappiello, A, Famiglini, G, Palma, P, Pierini, E, Termopoli, V, and Trufelli, H
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Chemical ionization ,Chromatography ,Chemistry ,Electrospray ionization ,Analytical chemistry ,Atmospheric-pressure chemical ionization ,Mass spectrometry ,Direct-EI, matrix effects ,Analytical Chemistry ,Matrix (chemical analysis) ,CHIM/01 - CHIMICA ANALITICA ,Liquid chromatography–mass spectrometry ,Direct electron ionization liquid chromatography–mass spectrometry interface ,Electron ionization - Abstract
A major limitation in quantitative analysis with electrospray ionization mass spectrometry (ESI-MS) is represented by the so-called matrix effects in which the matrix coextracted with the analytes can alter the signal response, causing either suppression or enhancement, resulting in poor analytical accuracy, linearity, and reproducibility. In the direct electron ionization liquid chromatography-mass spectrometry (direct-EI LC-MS) interface the ionization process is based on electron impact ionization, and it occurs in the gas phase and is not influenced by coeluted matrix compounds. In this work we quantitatively evaluated matrix effects on enriched environmental and biological samples, with different extraction procedures, using ESI and direct-EI LC-MS. As expected, the samples analyzed with direct-EI were not affected by matrix composition, whereas with ESI we observed either signal suppression or enhancement, depending on the sample nature.
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- 2009
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