Search

Poster session 1Poster session 1; We aimed to compare the effects of 8-week eccentric versus concentric exercise training in rats on body composition and energy expenditure, since these parameters have not been fully investigated. Animals were assigned to group 1) control, 2) +15% uphill-running slope (CON), 3) -15% downhill- running slope (ECC15, iso-power output) or 4) -30% downhill-running slope (ECC30, iso-VO2). Total body mass increased in all groups over the 8 weeks. A significant gain in fat mass was only observed for control group (20.71±1.99g) compared to CON (-4.8±6.18g); ECC15 (0.6±3.32g) and ECC30 (2.6±6.01g). A gain in lean mass was mainly seen for ECC15 (88.9±6.85g, p=0.09) and ECC30 (101.6±11.07g, p=0.02). Basal metabolic rate increased for all running groups. Thereby, the impact of training on lean mass is enhanced with ECC30 compared to CON, and adaptations are still observed for lower VO2 (ECC15). Thus low intensity eccentric exercise training could be part of body composition regulation strategies.

Benoit Borel,1,2 Courtney A Wilkinson-Maitland,3 Alan Hamilton,4 Jean Bourbeau,5 Hélène Perrault,6 Dennis Jensen,3,5,7 François Maltais2 1Laboratoire HAVAE, Université de Limoges, Limoges, France; 2Centre de Recherche, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, Québec, 3Clinical Exercise and Respiratory Physiology Laboratory, Department of Kinesiology and Physical Education, McGill University, Montréal, QC, 4Boehringer Ingelheim (Canada) Limited, Burlington, ON, 5Respiratory Epidemiology and Clinical Research Unit, Montreal Chest Institute, McGill University Health Center, Montreal, QC, 6Faculty of Health Sciences, University of Ottawa, Ottawa, ON, 7Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada Background: The aim of this study was to evaluate the responsiveness of the 3-minute constant rate step test (3-MST) to detect the relief of exertional dyspnea (respiratory discomfort) after acute bronchodilation in COPD patients. Patients and methods: A total of 40 patients with moderate-to-severe COPD (mean forced expiratory volume in 1second: 45.7 (±14.7), % predicted) performed four 3-MSTs at randomly assigned stepping rates of 14, 16, 20 and 24steps/min after inhalation of nebulized ipratropium bromide (500µg)/salbutamol (2.5mg) and saline placebo, which were randomized to order. Patients rated their intensity of perceived dyspnea at the end of each 3-MST using Borg 0–10 category ratio scale. Results: A total of 37 (92.5%), 36 (90%), 34 (85%) and 27 (67.5%) patients completed all 3minutes of exercise at 14, 16, 20 and 24 steps/min under both treatment conditions, respectively. Compared with placebo, ipratropium bromide/salbutamol significantly decreased dyspnea at the end of the third minute of exercise at 14 steps/min (by 0.6±1.0 Borg 0–10 scale units, P0.05). Conclusion: The 3-MST, when performed at 14 and 16 steps/min, was responsive to detect the relief of exertional dyspnea after acute bronchodilation in patients with moderate-to-severe COPD. Keywords: chronic obstructive pulmonary disease, exercise testing, dyspnea, intervention