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Intramolecular interactions between molecules have been reported as the most efficient way of synthesizing morphine molecules. A total of nine-step synthesis using intramolecular cycloaddition, also known as Diels-Alder reaction, has been so far the most successful way of synthesizing morphine. Tandem radical cyclization has also been proved to be efficient. Although both reactions are simple, they might be affected by stereochemistry. Thid paper proposes some possible ways of improving such intramolecular interactions.

Aim: To evaluate the technical feasibility and safety of a simultaneous surgery: laparoscopic appendectomy in combination with transabdominal preperitoneal hernia repair.Methods: The study was a retrospective analytical one. The medical histories were studied and postoperative monitoring of eleven patients hospitalized with acute appendicitis who underwent simultaneous surgery: laparoscopic appendectomy with simultaneous laparoscopic plastic surgery of clinically significant inguinal hernia was carried out. During the statistical analysis, the following parameters were evaluated: the timing of postoperative recovery, the frequency of early postoperative complications and the frequency of recurrence of inguinal hernia a year after surgery.Results: The surgery was successfully performed in all 11 patients. There were no cases of infectious complications of the surgical intervention area. Acute urinary retention was registered in one patient in the early postoperative period. In one case, an early adhesive intestinal obstruction was diagnosed, which was resolved with conservative treatment. There were no cases of recurrent inguinal hernia during the year.Conclusion: laparoscopic appendectomy in combination with transabdominal preperitoneal hernia repair can be used in the treatment of acute appendicitis in combination with inguinal hernia in the absence of signs of gangrenous appendicitis with purulent peritonitis. The low statistical power of the study does not allow us to draw conclusions about the safety of this approach for patients of the older age group with a high comorbidity index.

Heterostructure engineering combined with carbonaceous materials shows great promise toward promoting sluggish kinetics, improving electronic conductivity, and mitigating the huge expansion of transition metal sulfide electrodes for high-performance sodium storage. Herein, the iron sulfide-based heterostructures in situ hybridized with nitrogen-doped carbon nanotubes (Fe7S8/FeS2/NCNT) have been prepared through a successive pyrolysis and sulfidation approach. The Fe7S8/FeS2/NCNT heterostructure delivered a high reversible capacity of 403.2 mAh g−1 up to 100 cycles at 1.0 A g−1 and superior rate capability (273.4 mAh g−1 at 20.0 A g−1) in ester-based electrolyte. Meanwhile, the electrodes also demonstrated long-term cycling stability (466.7 mAh g−1 after 1,000 cycles at 5.0 A g−1) and outstanding rate capability (536.5 mAh g−1 at 20.0 A g−1) in ether-based electrolyte. This outstanding performance could be mainly attributed to the fast sodium-ion diffusion kinetics, high capacitive contribution, and convenient interfacial dynamics in ether-based electrolyte.

Potassium is one of the most important elements for crop growth and development. However, potassium deficiencies are common in the cultivated land of oil crops in the world, which limits the increase in their yields. The photosynthesis, fluorescence, and physiological indexes of peanut plants were affected by low K stress to varying degrees, and finally the yield decreased. However, the effect of low K stress on the photosynthetic physiological mechanism of peanut plants remains unclear. In this study, in order to explore the response mechanism of peanuts to low K stress, NH18 (tolerance to low K) and HY20 (intolerance to low K) were used to explore the effects of different peanut varieties under low K stress on the dry matter accumulation, protective enzyme activities, osmotic regulatory substance accumulation capacity, fluorescence characteristics, nutrient content, grain quality, and yield. The results of the 2-year experiment showed that under the stress of low K, the content of malondialdehyde in peanut leaves increased and the activities of NH18 superoxide dismutase (SOD) and peroxidase (POD) in the low-K-tolerant variety were higher than those in the low-K-intolerant variety HY20. The decrease in osmotic regulation caused by low K was compensated for by an increase in the soluble protein content. As a result, the chlorophyll content decreased significantly, F0 increased under dark adaptation, and Fm, Fv, and Fv/Fm decreased. The photosynthetic and fluorescence physiology of low-K-tolerant NH18 was less affected by low K stress. Furthermore, under low K stress, the dry matter accumulation of NH18 was reduced less, so that the final yield was less affected by low K stress than that of HY20. Under low K stress, the potassium content in the roots, stems, leaves, and fruit needles decreased significantly, and the decreasing range of stems and leaves gradually increased with the growth period, while that of the pod gradually decreased with the growth period. Under low K stress, the sodium content in the root system significantly increased and was significantly higher than that in the stem, leaf, pod, and fruit needle, indicating that the peanut plants actively absorbed more Na+ to replace the K+ function. This study clarified the mechanism of photosynthesis and the physiology of peanut plants under low K stress, which is of great significance for the breeding and cultivation of peanut resistance.

(1) Purpose: To compare and evaluate the immediate and long-term results of the use of various hernioplasties for the treatment of inguinal hernias after surgical treatment of prostate cancer; to determine the possibility of performing transabdominal preperitoneal (TAPP) hernioplasty and total extraperitoneal (eTEP) hernioplasty in patients with inguinal hernia during surgical treatment of prostate cancer. (2) Method: This study is a clinical analytical prospective study, without the use of randomization. The study included 220 patients with inguinal hernia, who were randomly divided into two groups (group A (n = 100) and group B (n = 120)). Patients in group A received eTEP, and those in group B received TAPP. The end points of the study were the results associated with the operation itself and the prognosis of the disease in the two groups. (3) Results: Group A: five patients had a scrotal hematoma, in 10 cases nosocomial pneumonia or infectious complications from the postoperative wound. The overall rate of early postoperative complications was 15%. In group B, the following postoperative complications were reported: one case of intestinal injury, six cases of acute urinary retention, eight cases of scrotal hematoma and 12 cases of nosocomial pneumonia or infectious complications from the postoperative wound were admitted. The overall incidence of early postoperative complications was 22.5%. There was no statistically significant difference in the incidence of postoperative complications between the two groups (χ2 (3) = 2.54, p > 0.05). (4) Conclusion: During the analysis of the obtained results, no statistically significant difference was found in the duration of hospitalization, the volume of blood loss, the severity of pain syndrome, postoperative complication incidence and recurrence incidence (p > 0.05); however, the comparison groups differed in the duration of the operation: the operation time in group A was much longer compared to group B (p < 0.05).

Belowground interactions mediated by root exudates are critical for the productivity and efficiency of intercropping systems. Herein, we investigated the process of microbial community assembly in maize, peanuts, and shared rhizosphere soil as well as their regulatory mechanisms on root exudates under different planting patterns by combining metabolomic and metagenomic analyses. The results showed that the yield of intercropped maize increased significantly by 21.05% (2020) and 52.81% (2021), while the yield of intercropped peanut significantly decreased by 39.51% (2020) and 32.58% (2021). The nitrogen accumulation was significantly higher in the roots of the intercropped maize than in those of sole maize at 120 days after sowing, it increased by 129.16% (2020) and 151.93% (2021), respectively. The stems and leaves of intercropped peanut significantly decreased by 5.13 and 22.23% (2020) and 14.45 and 24.54% (2021), respectively. The root interaction had a significant effect on the content of ammonium nitrogen (NH4+-N) as well as the activities of urease (UE), nitrate reductase (NR), protease (Pro), and dehydrogenase (DHO) in the rhizosphere soil. A combined network analysis showed that the content of NH4+-N as well as the enzyme activities of UE, NR and Pro increased in the rhizosphere soil, resulting in cyanidin 3-sambubioside 5-glucoside and cyanidin 3-O-(6-Op-coumaroyl) glucoside-5-O-glucoside; shisonin were significantly up-regulated in the shared soil of intercropped maize and peanut, reshaped the bacterial community composition, and increased the relative abundance of Bradyrhizobium. These results indicate that interspecific root interactions improved the soil microenvironment, regulated the absorption and utilization of nitrogen nutrients, and provided a theoretical basis for high yield and sustainable development in the intercropping of maize and peanut.

Belowground interactions mediated by root exudates are critical for the productivity and efficiency of intercropping systems. Herein, we investigated the process of microbial community assembly in maize, peanuts, and shared rhizosphere soil as well as their regulatory mechanisms on root exudates under different planting patterns by combining metabolomic and metagenomic analyses. The results showed that the yield of intercropped maize increased significantly by 21.05% (2020) and 52.81% (2021), while the yield of intercropped peanut significantly decreased by 39.51% (2020) and 32.58% (2021). The nitrogen accumulation was significantly higher in the roots of the intercropped maize than in those of sole maize at 120 days after sowing, it increased by 129.16% (2020) and 151.93% (2021), respectively. The stems and leaves of intercropped peanut significantly decreased by 5.13 and 22.23% (2020) and 14.45 and 24.54% (2021), respectively. The root interaction had a significant effect on the content of ammonium nitrogen (NH

Objective: To investigate the differential expression of microRNA (miRNA) in patients with endometrial cancer and its relationship with prognosis and survival. Method: We used The Cancer Genome Atlas (TCGA) database to analyze differentially expressed miRNAs in endometrial cancer tissues and adjacent normal tissues. In addition, we successfully screened out key microRNAs to build nomogram models for predicting prognosis and we performed survival analysis on the key miRNAs as well. Result: We identified 187 differentially expressed miRNAs, which includes 134 up-regulated miRNAs and 53 down-regulated miRNAs. Further univariate Cox regression analysis screened out 47 significantly differentially expressed miRNAs and selected 12 miRNAs from which the prognostic nomogram model for ECA patients by LASSO analysis was constructed. Survival analysis showed that high expression of hsa-mir-138-2, hsa-mir-548f-1, hsa-mir-934, hsa-mir-940, and hsa-mir-4758 as well as low-expression of hsa-mir-146a, hsa-mir-3170, hsa-mir-3614, hsa-mir-3616, and hsa-mir-4687 are associated with poor prognosis in EC patients. However, significant correlations between the expressions levels of has-mir-876 and hsa-mir-1269a and patients’ prognosis are not found. Conclusion: Our study found that 12 significantly differentially expressed miRNAs might promote the proliferation, invasion, and metastasis of cancer cells by regulating the expression of upstream target genes, thereby affecting the prognosis of patients with endometrial cancer.