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Wolfiporia cocos is commonly used as a traditional Chinese medicine for its diuretic, tonifying, and invigorating effects on the spleen. However, the epidermis of W. cocos is discarded as scrap during harvesting because of its low price, resulting in a great waste of resources and environmental pollution. In this work, the epidermis of W. cocos was studied and three new lanostane triterpenoids were isolated. The structures were determined using NMR and HRESIMS, with absolute configurations established by comparison of the calculated and experimental ECD spectra. The three new compounds were evaluated for their antimicrobial activities in vitro against Staphylococcus aureus, Escherichia coli, and Saccharomyces cerevisiae. None of the tested compounds showed inhibition against these three strains of indicator microbes at a concentration of 128 μg/ml. This study provides a reference for further medicinal development and the utilization of the epidermis of W. cocos.

Nano drug delivery systems are a research hotspot in the field of tumor therapy. In this work, molybdenum disulfide (MoS

In this work, two MOFs, {[Cd3(L)2(m-BDC)(NO3)4]��2(H2O)}n (1) and [Zn3(L)(m-BDC)3]n (2), were synthesized using the hydrothermal method. Single crystal diffraction showed that the flexible tripod ligand L (1,3,5-[1-(2-methylimidazole-methylene)]benzene) delivers completely different configurations under the influence of the coordination metal [Cd(II), Zn(II)] ions, resulting in two completely different structures. In 1, the flexible tripod ligand L adopted a "chair" conformation which combined with Cd(II) ions, forming a two-dimensional structure in the orthorhombic C2221 space group. In 2, L adopted a "bowl" conformation which combined with Zn(II) ions, forming another two-dimensional structure in the P-3m1 space group. The synthesized MOFs were characterized by PXRD, thermogravimetry (TGA), infrared spectroscopy (IR), elemental analysis, fluorescence property analysis, Hirshfeld surface analysis, and density functional theory (DFT) quantitative calculations. The fluorescence analysis displayed that the maximum emission wavelength of 1 and 2 has a blue shift. In addition, the results of thermogravimetric analysis (TGA) showed that the thermal stability of 1 is 150 ��C higher than that of 2. This is probably because the energy of "chair" conformation is lower than that of the "bowl" conformation, which makes 1 more stable than that of 2.

Purpose. The most prevalent primary malignant tumor of CNS is glioma, which has a dismal prognosis. The theory of oxidative stress is one of the important theories in the study of its occurrence and development mechanism. In this study, the impacts of PCBP2 on glioma sufferers and the possible mechanisms were examined. Methods. Patients with glioma were obtained from May 2017 to July 2018. Quantitative PCR, microarray analysis, western blot analysis, and immunofluorescence were used in this experiment. Results. PCBP2 mRNA expression level and protein expression in patients with glioma were upregulated compared with paracancerous tissue. OS and DFS of PCBP2 low expression in patients with glioma were higher than those of PCBP2 high expression. PCBP2 promoted the progression and metastasis of glioma. PCBP2 reduced oxidative stress-induced apoptosis of glioma. PCBP2 suppressed the cGAS/STING pathway of glioma. PCBP2 protein interlinked with cGAS and cGAS was one target for PCBP2. METTL3-mediated m6A modification increases PCBP2 stability. Conclusion. Along the cGAS-STING signal pathway, PCBP2 decreased the apoptosis that oxidative stress-induced glioma caused, which might be a potential target to suppress oxidative stress-induced apoptosis of glioma.

Background: The Squamous cell carcinoma of the palate is rare; women are more affected than men. This study aimed to discuss the etiology, diagnostic modalities, prognosis factors, and treatment strategies. Case: A 49-year-old woman was admitted to our department in 2019 with a chief complaint of a hard and painful mass on the right palate. The Clinical assessment revealed a palatal tumor extended to 3/4 of hard palate and part of the soft palate, with hard consistency, no mobility, cauliflower-like surface partly covered by a white pseudo-membrane, dark red-colored, and clinically negative neck. 3D CT scan of palate and maxilla revealed malignant lesion features, Cervical MRI and Chest CT revealed enlarged lymph nodes. The histopathological assessment diagnosed keratinizing squamous cell carcinoma of the right palate. Resection of the tumor and Reconstructive surgery were performed. The postoperative outcomes were simple. Conclusion: Hepatitis B virus, local chronic inflammation were the risk factors incriminated in this case. The prognosis factors such as patient age, tumor size, lymph node involvement, bone invasion, and pathological grade influence the treatment and survival. Selective neck dissection, Ablative surgery, and Reconstruction with Submental island flap represented our management strategy for keratinizing squamous cell carcinoma of the palate.

C27H18CdN6O4, triclinic, P1‾$P‾{1}$ (no. 2), a = 10.2994(8) Å, b = 10.7795(7) Å, c = 11.0038(7) Å, α = 89.778(5)°, β = 78.046(6)°, γ = 83.049(6)°, Z = 2, V = 1186.11(14) Å3, Rgt(F) = 0.0402, wRref(F2) = 0.0809, T = 293 K.

The article contains sections titled: 1. Introduction 2. History 3. Physical and Chemical Properties 4. Analysis 5. Occurrence and Sources of Vitamin C 6. Biosynthesis 7. Manufacture of Vitamin C 7.1. Reichstein Synthesis 7.2. Industrial Manufacture by the Reichstein Route 7.3. Other Methods for Production of Ascorbic Acid 8. Absorption and Metabolism 9. Medical Aspects of Vitamin C 10. Industrial Uses 11. Economic Aspects

Non-coding RNAs (ncRNAs) induced competing endogenous RNAs (ceRNA) play crucial roles in various biological process by regulating target gene expression. However, the studies of ceRNA networks in the regulation of ovarian ovulation processing of chicken remains deficient compared to that in mammals. Our present study revealed that circEML1 was differential expressed in hen's ovarian tissues at different ages (15 W/20 W/30 W/68 W) and identified as a loop structure from EML1 pre-mRNA, which promoted the expressions of CYP19A1/StAR and E2/P4 secretion in follicular granulosa cells (GCs). Furthermore, circEML1 could serve as a sponge of gga-miR-449a and also found that IGF2BP3 was targeted by gga-miR-449a to co-participate in the steroidogenesis, which possibly act the regulatory role via mTOR/p38MAPK pathways. Meanwhile, in the rescue experiment, gga-miR-449a could reverse the promoting role of circEML1 to IGF2BP3 and steroidogenesis. Eventually, this study suggested that circEML1/gga-miR-449a/IGF2BP3 axis exerted an important role in the steroidogenesis in GCs of chicken.

C27H18CdN6O4, triclinic, P 1 ‾ $P‾{1}$ (no. 2), a = 10.2994(8) Å, b = 10.7795(7) Å, c = 11.0038(7) Å, α = 89.778(5)°, β = 78.046(6)°, γ = 83.049(6)°, Z = 2, V = 1186.11(14) Å3, R gt (F) = 0.0402, wR ref (F 2) = 0.0809, T = 293 K.

Adiponectin is an important adipocytokine and plays the roles in multiple metabolic processes via binding its receptors - AdipoR1 and AdipoR2, which has also been found to participate in the regulation of the reproductive system of animals, in particular by influencing the secretion of ovarian steroid hormones. To further investigate the expression of adiponectin and its receptors in follicles after in vitro incubation, and their role in the steroid synthesis of laying hens’ ovaries, we performed qRT-PCR and ELISA to detect the expressions of AdipoQ, AdipoR1, and AidpoR2, and determined the key genes involved in steroidogenesis and the secretion of estradiol (E2) and progesterone (P4) through the in vitro activation of adiponectin (AipoRon) and overexpression or knockdown of AdipoR1 and AdipoR2. Our results revealed that adiponectin and its receptors wildly exist in follicles and granulosa cells, and AdipoRon (5 and 10 µg/mL) had no effect on granulosa cell proliferation and apoptosis but significantly stimulated the secretion of adiponectin and its receptors in granulosa cells after incubation for 24 h. Furthermore, AdipoRon could significantly stimulate the secretion of P4 and inhibit E2 level compared to those of the control group through modulating the key genes expression of steroidogenesis (CYP19A1, StAR, CYP11A1, FSHR, and LHR). The secretion of E2 was also decreased in granulosa cells by the treatments of overexpression and knockdown of AdipoR1/2, however, there was no difference in terms of the level of P4 and StAR expression between them if there was overexpression or knockdown of AdipoR1/2. In addition, it was shown that the secretion of E2 only exhibits a marked drop if co-processing 10 µg/mL AdipoRon and pGMLV AdipoR2 compared to single treatments. Taken together, the study highlighted the role of adiponectin and its receptors in the regulation of steroid synthesis and secretion in ovarian granulosa cells in laying hens.

We exploit an exchange-mandated increase of the maximum order size, in the U.S. corn calendar spread market, in order to investigate the connection between exogenous constraints on order placement and execution, volatility, and liquidity. We show that the old maximum of 2,500 contracts was binding, and that demand exists for placing and executing much larger orders. The limit-order book depth (at the best bid and ask) increases dramatically after the exchange quadruples the maximum order size to 10,000 contracts. Intraday realized volatility is not statistically significantly different before and after the rule change. Amid increased market depth and stable volatility, we document that quoted and effective spreads both narrow significantly and that the price impact of large trades is smaller. In sum, market quality is higher after the maximum order size change.

Nutrition is closely related to the health of the elderly population. This study aimed to provide a comprehensive picture of the nutrition status of elderly Chinese and its related dietary, geographical, and socioeconomic factors.A total of 13,987 ≥ 60-year-old persons from the 2010-2013 Chinese National Nutrition and Health Survey were included to evaluate various aspects of malnutrition, including underweight, overweight or obesity, and micronutrient inadequacy.Overall, the prevalence of obesity, overweight, and underweight was 12.4%, 34.8%, and 5.7%, respectively, with disparities both geographically and socioeconomically. The prevalence of underweight was higher among the older old (≥ 75 years), rural residents and those with low income, with low education status, and residing in undeveloped West areas. More than 75% of the elderly do not meet the Dietary Reference Intakes for vitamins A, BObesity epidemic, inadequacy of micronutrient intake, and high prevalence of underweight and anemia in susceptible older people are the major nutrition challenges for the rapidly aging population in China.

To investigate the association between blood pressure and all-cause mortality in Shanxi, China.The '2002 China Nutrition and Health Survey' baseline data in Shanxi province was used. A retrospective investigation was performed in 2015. The effects of SBP and DBP on the all-cause mortality were analyzed using the Cox regression model. The hazard ratio (The follow-up rate was 76.52% over 13 years, while the cumulative mortality rate for all participants was 917.12/100,000 person-years. The mortality rose with an increasing SBP (Adults with SBP160 mmHg and DBP100 mmHg had a higher mortality risk. Sex and age difference was noted in both DBP and mortality risk.

In the context of this work, important trends in the influence of the metal center, coligand, and alkyne reaction partner on the iClick reaction of square-planar palladium(II) and platinum(II) complexes with a N^N^N, C^N^N, or S^N^N coordination sphere and a number of internal as well as terminal alkynes were elaborated. Preliminary bioactivity studies on a human cancer cell line gave low micromolar EC50 values, for the most promising compound comparable to cisplatin serving as a reference drug. The further application of the iClick reaction to bioconjugation will be explored in future work., Insgesamt konnten im Rahmen dieser Arbeit systematische Einflüsse des Metallzentrums, des Coliganden und des Alkins auf die Geschwindigkeit der iClick-Reaktion von quadratisch-planaren Palladium(II)- und Platin(II)-Azid-Komplexen mit internen und terminalen Alkinen identifiziert werden. So reagiert auch in dieser Serie das 4d-Element schneller als das entsprechend 5d-Metall, interne Alkinen mit elektronenarmen Substituenten führen zu einer höheren Reaktionsgeschwindigkeit als terminale Alkine und Geschwindigkeitskonstante steigt für tridentate Chelatliganden in der Reihenfolge N^N^N < S^N^N < C^N^N an. Erste orientierende biologische Studien an menschlichen Tumorzellen ergaben vielversprechende EC50-Werte im unteren mikromolaren Bereich. Das Potential dieser Verbindungen und der iClick-Reaktion allgemein für die Biokonjugation und tiefgehende Untersuchungen des Mechanismus der Antitumor-Wirkung sollte in zukünftigen Studien noch weiter ausgedehnt werden.

The object of this paper is to reduce soot emissions under typical 5s transient conditions of constant speed and increasing torque. And effects of fuel injection timing on combustion and emissions parameters were experimentally and numerically studied in a regulated two-stage turbocharged diesel engine with a turbine bypass valve (TBV). The test results indicated that: the smaller TBV opening could improve deterioration of smoke emissions and BSFC at medium and heavy loads. Afterward, the full-stage injection timing (FSIT) strategies (delaying injection timing during the entire transient process) could reduce soot and NOX emissions simultaneously. However, when TBV opening became larger, smoke emissions and BSFC were deteriorated gradually. Moreover, the sectional-stage injection timing (SSIT) strategies (advancing injection timing from 10 % load to a preset load and delaying injection timing from the preset load to 100 % load) could markedly reduce soot emissions by 75.8 % with TBV opening 20 %; the degradation of fuel consumption could be effectively suppressed. Finally, coupling the SSIT strategies with the TBV control strategies could significantly improve the transient performance.

A new indole alkaloid, nauclorienine (1), along with seven known alkaloids (2–8), were isolated from the stems and leaves of Nauclea orientalis. Among them, nauclorienine (1) was a new indole alkaloid holding a rare corynanthe-type skeleton, and the known compounds (2–8) were isolated from N. orientalis for the first time. Their structures were elucidated on the basis of extensive spectroscopic data analyses. All isolated compounds were evaluated for their cytotoxicities against five human cancer cell lines: HL-60, SMMC-7721, A-549, MCF-7 and SW480 in vitro. Alkaloids 1–4 exhibited significant inhibitory effects against various human cancer cell lines with IC50 values comparable to those of cisplatin.

A collection of novel spiroheterocycles with strained aziridine moieties have been facilely synthesized by using easily accessible starting materials under mild reaction conditions. This procedure is robust, scalable and highly diastereoselective, and also features broad substrate scope. In addition, some of the products show promising in vitro biological activity against a spectrum of pathogens, which might be considered as a clue for the discovery of new antimicrobial agents.

IntroductionSpinal cord injury (SCI) alters the integrity of the spinal cord, which leads to loss of multiple organs’ function including locomotor function. The present study evaluates the protective effect of tabersonine against SCI.Material and methodsSCI was induced by traumatic injury and animals were treated with tabersonine 20 and 40 mg/kg, intraperitoneally for the period of 10 days. Tabersonine’s effect was determined by estimating locomotor and neurological function in spinal cord injured rats. Moreover, mediators of inflammation were estimated using enzyme-linked immunosorbent assay (ELISA) and the effect of tabersonine on Notch/inflammasome signaling was estimated by reverse transcription polymerase chain reaction (RT-PCR), western blot assay and immunohistochemistry. Apoptosis of neuronal cells was estimated by staining with Nissl stain on spinal cord tissue in SCI rats.ResultsData of the study suggest that neurological and motor functions were improved in the tabersonine treated group compared to the spinal cord injured (SI) group. There was a decrease in the mediators of inflammation in the spinal cord tissue of the tabersonine treated group compared to the SI group. Treatment with tabersonine ameliorates the altered expression of NICD, Nestin and Hes-1 protein and mRNA expression of Notch-1 and Hes-1 in the SCI rats. It was also observed that the tabersonine treated group showed activation of CREB and inhibition of the NLRP-3 pathway in SCI rats. Moreover, apoptosis of neuronal cells was reduced in the tabersonine treated group compared to the SI group.ConclusionsData of the investigation suggest that tabersonine protects against spinal cord injury by activating CREB and reducing NLRP3/Notch signaling.

OBJECTIVE To investigate the trends of lipid profiles and dyslipidemia among Chinese adults from 2002 to 2015. METHODS Data were collected from three nationally representative cross-sectional surveys. Fasting venous blood samples were collected and serum lipids were tested by biochemical analysis and enzymatic determination. Lipid levels and the prevalence of dyslipidemia among adults were analyzed with complex sampling weighting adjustment for age and gender. RESULTS The weighted means of TC, TG, and LDL-c significantly increased linearly from 3.93, 1.12, and 2.12 mmol/L in 2002 to 4.59, 1.41, and 2.78 mmol/L in 2010 and then to 4.63, 1.47, and 2.87 mmol/L in 2015, respectively; by contrast, HDL-c levels decreased significantly from 1.30 mmol/L to 1.26 mmol/L over the same period. Similar trends in mean non-HDL-c and lipid-related ratios were observed. The weighted dyslipidemia prevalence linearly increased; in particular, hypercholesterolemia increased from 1.6% to 5.6% and then to 5.8%, hypertriglyceridemia increased from 5.7% to 13.6% and then to 15.0%, low HDL-c increased from 18.8% to 35.5% and then to 24.9%, and high LDL-c increased from 1.3% to 5.6% and then to 7.2% (P for trend0.001). CONCLUSION Dyslipidemia increased among Chinese adults from 2002 to 2015. Development of a comprehensive strategy to decrease lipid levels in this population is urgently required.

This study aimed to assess the association of waist circumference (WC) with all-cause mortality among Chinese adults.The baseline data were from Shanxi Province of 2002 China Nutrition and Health Survey. The death investigation and follow-up visit were conducted from December 2015 to March 2016. The visits covered up to 5,360 of 7,007 participants, representing a response rate of 76.5%. The Cox regression model and floating absolute risk were used to estimate hazard ratio and 95% floatingThis study followed 67,129 person-years for 12.5 years on average, including 615 deaths. The mortality density was 916 per 100,000 person-years. Low WC was associated with all-cause mortality among men. Multifactor-adjusted hazard ratios (WC was an important predictor of death independent of body mass index (BMI). WC should be used as a simple rapid screening and predictive indicator of the risk of death.

Men who have sex with men (MSM) disclose same-sex behaviors with others, creating disclosure networks. This study examined the characteristics of disclosure networks that are associated with HIV testing among MSM in China through an online nationwide survey. Name-generator questions were used to ask each participant ("ego") to nominate up to five social network members ("alters") with whom he had disclosed same-sex behaviors. Among the 806 men, the average disclosure network size was 4.05. MSM who reported larger disclosure networks were more likely to have been tested for HIV (aOR 1.21, 95% CI 1.08-1.34). The most common disclosure network alters were friends (45.1%), followed by sex partners (18.7%) and healthcare professionals (2.5%). Men who disclosed to healthcare professionals were more likely to test for HIV compared to men who disclosed to family members (aOR 5.43, 95% CI 2.11-14.04). Our findings can inform disclosure network-based interventions to promote MSM HIV testing.

Obesity is recognized as a significant risk factor for diabetes and hypertension. The present study aimed to examine the associations between adults'obesity risk and childhood and parental obesity.A total of 204 children aged 6-17 years were recruited in 2002 with an average follow-up period of 13.2 years. Height and body weight were measured by trained staffs. Overweight and obesity were defined based on the Chinese standard for children and adults. T-test, analysis of variance, and Chi-square analysis were used for single factor analysis. Multiple linear and logistic regression analyses were used to perform multifactor analysis.The percentage of non-obese children who grew up to be non-obese adults was 62.6%, and that of obese children who grew up to be obese adults was 80.0%. There was a significant association between childhood body mass index (BMI) and adulthood BMI with a β regression coefficient of 3.76 [95% confidence interval (CI): 1.36-6.16], and between childhood obesity and adulthood obesity with an odds ratio of 5.76 (95% CI: 1.37-24.34). There was no statistical difference between parental obesity at baseline and children's adulthood obesity, after adjustment of confounders. Male participants and those aged 10.0-13.0 years had a higher risk of adulthood obesity with odds ratios of 2.50 (95% CI: 1.12-5.26) and 3.62 (95% CI: 1.17-11.24), respectively.Childhood obesity is an important predictor of adulthood obesity.

The asynchronous motor full-order flux observer uses the motor itself as a reference model to observe the motor’s flux and stator current by constructing a state equation. It takes the stator current output and introduces the error between the actual current and the observed current as feedback correction, and improves the performance of the full-order flux observer by adjusting the feedback gain of the correction item. Based on the in-depth analysis of the zero and pole images of the open-loop transfer function of the small signal linearized model, a feedback matrix design method is proposed to improve the smooth switching of the full order flux observer and the dynamic performance of the full order flux observer speed identification. Simulation results verify the correctness of the analysis method and the feasibility of the proposed countermeasures.

Objective: To study the relationship of serum CCL20 and PCDGF levels with recurrence of non-small cell lung cancer after thoracoscopic radical operation. Method: A total of 93 patients with non-small cell lung cancer who received thoracoscopic radical operation in our hospital were selected, followed up for 2 years and divided into recurrence group and non-recurrence group, serum was collected before operation as well as 30 d and 90 d after operation to determine CCL20 and PCDGF levels, chest CT perfusion imaging was carried out after recurrence and the perfusion parameters were measured, and recurrent tumor tissue was collected to determine apoptosis molecule levels. Results: Before operation as well as 30 d and 90 d after operation, serum CCL20 and PCDGF levels of recurrence group and nonrecurrence group were not significantly different; 180 d after operation, serum CCL20 and PCDGF levels of recurrence group were significantly higher than those of non-recurrence group, and there were significant differences between two groups. Patients with recurrence were grouped according to serum CCL20 and PCDGF levels 180 d after operation, BF, BV and PS of recurrent patients with high CCL20 and PCDGF levels were sig.nificantly higher than those of recurrent patients with low CCL20 and PCDGF levels while MTT and TTP as well as Caspase-3, -8, -9, pULK, Beclin1, PICKC3, Atg21 and Atg24 levels in tumor tissue were lower than those of recurrent patients with low CCL20 and PCDGF levels. Conclusion: Monitoring of postoperative serum CCL20 and PCDGF levels can provide reference for the evaluation of postoperative non-small cell lung cancer recurrence, and serum CCL20 and PCDGF levels 180 d after operation are closely related to tumor tissue perfusion and cell apoptosis.

Young stroke patients have a strong desire to return to the society, but few studies have been conducted on their rehabilitation training items, intensity, and prognosis. We analyzed clinical data of young and middle-aged/older stroke patients hospitalized in the Department of Neurological Rehabilitation, China Rehabilitation Research Center, Capital Medical University, China from February 2014 to May 2015. Results demonstrated that hemorrhagic stroke (59.6%) was the primary stroke type found in the young group, while ischemic stroke (60.0%) was the main type detected in the middle-aged/older group. Compared with older stroke patients, education level and incidence of hyperhomocysteinemia were higher in younger stroke patients, whereas, incidences of hypertension, diabetes, and heart disease were lower. The average length of hospital stay was longer in the young group than in the middle-aged/older group. The main risk factors observed in the young stroke patients were hypertension, drinking, smoking, hyperlipidemia, hyperhomocysteinemia, diabetes, previous history of stroke, and heart disease. The most accepted rehabilitation program consisted of physiotherapy, occupational therapy, speech therapy, acupuncture and moxibustion. Average rehabilitation training time was 2.5 hours/day. Barthel Index and modified Rankin Scale scores were increased at discharge. Six months after discharge, the degree of occupational and economic satisfaction declined, and there were no changes in family life satisfaction. The degrees of other life satisfaction (such as friendship) improved. The degree of disability and functional status improved significantly in young stroke patients after professional rehabilitation, but the number of patients who returned to society within 6 months after stroke was still small.

Summary Flexible electronics have been rapidly developed in recent years. However, there are still some concerns about the degradation and short life caused by mechanical damage during their operation. Here, we present a self-healing electret nanogenerator (SENG) that can restore its structure and function after mechanical damage, benefiting from a healable polymer with reversible imine bond and the instantaneous healing ability of liquid metal. After destructive testing comprising four cutting-healing cycles the output current of the SENG autonomously recovers to the original values before damage. Finally, as a practical device, the SENG is demonstrated to work in both energy harvesting and human physiology-monitoring applications. This research offers a feasible route for improving reliability and lifetime of electret generators or other flexible electronics that suffer from mechanical damage.

The potential for therapeutic antibody treatment of neurological diseases is limited by poor penetration across the blood-brain barrier. I.c.v. delivery is a promising route to the brain; however, it is unclear how efficiently antibodies delivered i.c.v. penetrate the cerebrospinal spinal fluid (CSF)-brain barrier and distribute throughout the brain parenchyma.We evaluated the pharmacokinetics and pharmacodynamics of an inhibitory monoclonal antibody against β-secretase 1 (anti-BACE1) following continuous infusion into the left lateral ventricle of healthy adult cynomolgus monkeys.Animals infused with anti-BACE1 i.c.v. showed a robust and sustained reduction (~70%) of CSF amyloid-β (Aβ) peptides. Antibody distribution was near uniform across the brain parenchyma, ranging from 20 to 40 nM, resulting in a ~50% reduction of Aβ in the cortical parenchyma. In contrast, animals administered anti-BACE1 i.v. showed no significant change in CSF or cortical Aβ levels and had a low (~0.6 nM) antibody concentration in the brain.I.c.v. administration of anti-BACE1 resulted in enhanced BACE1 target engagement and inhibition, with a corresponding dramatic reduction in CNS Aβ concentrations, due to enhanced brain exposure to antibody.

AIM: To evaluate the efficacy of Goji berry supplementation on improving macular pigment, serum zeaxanthin levels and visual acuity in patients with early age-related macular degeneration (AMD). METHODS: A total of 114 patients (aged from 51 to 92y, mean age 69.53±8.41y) with early AMD were enrolled in our prospective, randomized controlled study. The included patients were assigned randomly to the Goji group (n=57) with 25 g of Goji berries supplementation per day for 90d and the control group (n=57) with their normal diet for 90d. Macular pigment optical density (MPOD) was measured using heterochromatic flicker photometry (HFP). The levels of serum lutein (L)/zeaxanthin (Z) were analyzed using high-performance liquid chromatography (HPLC). MPOD, serum L/Z levels and best corrected visual acuity (BCVA) were recorded at baseline and 90d. RESULTS: In the Goji group, there were no statistically significant differences in the serum L levels between the baseline (0.199±0.149 µmol/mL) and 90d (0.203±0.181 µmol/mL) (t=-0.186, P=0.850); however the serum Z levels were increased at 90d (0.101±0.087 µmol/mL) compared with those at the baseline (0.029±0.032 µmol/mL) (t=6.412, P

This study aimed to bolster knowledge regarding the factors affecting adoption behaviors of online dating sites. We held the view that the adoption of online dating sites is not only a diffusion of innovation process but also an outcome of the interactions among individual, peers and society. Using the data collected from a telephone interview by the Pew Research Center’s Internet and American Life Project in U.S., this study explored the role of perceived usefulness, perceived peer influence and perceived social reality in the adoption process. As a result, perceived usefulness of online dating sites was found to be the principal factor in influencing one’s choice of online dating sites. Also, perceived peer influence had been considered as another influential factor in this adoption process. However, perceived social reality had shown no impacts towards this adoption decision.

Cascaded H-bridges inverter has been gaining its ground in recent years because it can satisfy high voltage and power applications with medium volume semiconductors; however, it uses much more semiconductors than the traditional inverters which would increase the fault possibilities. Just because this case Cascaded H-bridges inverter is limited in many important industrial fields. In this paper, we, firstly, discussed the basic unit of Cascaded H-bridges inverter (namely, full-bridge inverter) and classify its inner faults, then we proposed a method to spot the faulty IGBT using neural network. We have also done lots of jobs on this fields which could be seen in the papers of our team.

The ecological restoration of mining wasteland has been highly concerned about the world. Consequences of mining wasteland without governance has brought economic development and human survival posed a serious threat, so the ecological restoration of abandoned mining area has been imperative. This paper summarizes the research status and development process of ecological restoration and abroad, as well as some of the issues raised ecological restoration work currently exists.

Based on the characteristic of an ultrasonic sensor that can sense the external environment, we design an intelligent vehicle with obstacle avoidance function. First, we use MSP430 as the core of the design system. Second, we distribute the ultrasonic sensor evenly on the round zone of the obstacles to process the data and ambient temperature, which is transmitted from the ultrasonic receiver through the SCM (what is SCM, explain). Finally, we make it to realize the functions of intelligent controlling and avoiding obstacles automatically.

The working mechanism of ferrochrome in a new type of copper-based P/ M friction material was studied. The results show that ferrochrome can significantly improve the hardness of the matrix, high temperature resistance, corrosion resistance and other performance of the copper-based friction material, especially the mechanical performance, the friction and wear properties. The affinity of Cr and O is greater than Fe and O. CrO or Cr2O3is formed by Cr which can work as the reduction in the sintering process, thats why the friction coefficient and wear resistance are improved.

By adopting CFD numerical simulation software, the steady numerical simulation of original engine inlet is carried on. On base of the original one, two new inlets are redesigned and their velocity fields are analyzed. From the simulation of CFD, we can learn that with the different inlet, the average flow velocity increases when the swirl ratio rises in same cross-section. Then the experiment of inlets with different geometry is carried on. Considered various kinds of performance of the engine, we found that the swirl ratio which is generated by the inlet should not be too high, but it also is not good with too low swirl ratio. In this investigation, comprehensive consideration of economy and power, the no.1 inlet is selected as the best one for the next study.

Terahertz time-domain spectroscopy (THz-TDS) has emerged as a powerful tool for materials characterization and imaging. A trend towards size reduction, higher component integration and performance improvement for advanced THz-TDS systems is of increasing interest. The use of single semiconducting nanowires for terahertz (THz) detection is a nascent field that has great potential to realize future highly-integrated THz systems. In order to develop such components, optimized material optoelectronic properties and careful device design are necessary. Here, we present antenna-optimized photoconductive detectors based on single InP nanowires with superior properties of high carrier mobility (~1260 cm2V–1s–1) and low dark current (~10 pA), which exhibit excellent sensitivity and broadband performance. We demonstrate that these nanowire THz detectors can provide high quality time-domain spectra for materials characterization in a THz-TDS system, a critical step towards future application in advanced THz-TDS system with high spectral and spatial resolution

To investigate the Application Performances of the anionic gemini surfactant Ethanediyl-α,ω-bis(sodium N-lauroyl-β-alaninate)(EBLA) as silk degumming auxiliaries, the surface activity of the gemini surfactant was measured by the surface tension method. The dependence of degumming rate on surfactant concentration and degumming time were discussed, and the whiteness, tensile strength and capillary effect of the degummed silk fabric were measured. The results revealed that the gemini surfactant possessed excellent surface activities and its degumming effect was pretty good, the critical micelle concentration(CMC) of EBLA was 4.74×10-5 mol·dm-3, and the surface tension at the CMC(γCMC) of it was 26.6 mN·m-1. With lower dosage of the surface active agent and shorter degumming time, the perform indexes of the fabric degummed by the gemini surfactant EBLA were better than those of the fabric degummed by marseille soap.

The dipole spacing can directly affects the detecting sensitivity and accuracy in the landfill leakage detection by the high voltage direct current method. Based on the high voltage DC detecting model, the impact of dipole spacing on locating leaks is analyzed taking a single leak and multiple leaks as example. The results show that the greater the dipole spacing is, the higher the detecting sensitivity is; the smaller the dipole spacing is, the higher the detecting accuracy is. For multiple leaks, only one leak can be located when the dipole spacing is greater than the distance between the two leaks. In order to detect all leaks correctly, the dipole spacing should be smaller than the distance between the two leaks.

Summary Objectives On 12 May 2008, an earthquake with a magnitude of 8.0 on the Richter scale struck in Sichuan province, China. After the disaster, approximately 5 million people were living in temporary shelters. The objectives of this study were: (1) to provide the basic information on public health outcomes among the survivors; (2) to compare these outcomes between counties affected to differing extents by the earthquake; and (3) to identify important policies and programmes associated with public health outcomes. Study design Cross-sectional multicluster sample surveys were employed using data collected from two counties. Methods Cross-sectional surveys were conducted in August 2008 in two counties in Sichuan province. The study outcomes [physical component summary (PCS) and mental component summary (MCS)] were measured using Short Form-12. Independent demographic, socio-economic and trauma exposure variables were also measured. Multivariate regression analysis was conducted to investigate associations between the independent variables and PCS and MCS outcomes. Results In total, 3862 interviews were completed in the two counties. The mean PCS score was 37.6 [95% confidence interval (95% CI 35.13–41.97) in Beichuan county and 45.4 (95% CI 44.30–45.95) in Langzhong county. MCS scores were 36.8 (95% CI 33.61–40.71) in Beichuan county and 49.6 (95% CI 49.69–50.01) in Langzhong county, well below the instrument norm of 50. Variables with negative associations with physical or mental health included: female gender, living in a temporary shelter, higher income, deaths among family/friends, family property damaged and illness within the past 2 weeks. Higher frequencies of trauma exposure (more than six trauma exposure events) showed a strong significant negative association with PCS and MCS in both counties. Conclusions Interventions should be designed to focus on people without a household income (or a lower income), living in shelters or temporary houses. Governments should support income-generating activities and improve living conditions and public health status.

The objective of this study was to share the experience of building an information security system for a regional collaborative medical platform (RCMP) and discuss the lessons learned from practical projects. Safety measures are analyzed from the perspective of system engineering. We present the essential requirements, critical architectures, and policies for system security of regional collaborative medical platforms.

Data sharing and information exchange among medical institutions is a requirement for convenient and effective data availability for both healthcare professionals and patients. In this article, the characteristics of medical data are studied; two mainstream technologies of data storage for medical information are compared and three strategies of medical documents storage are described with detailed advantages and disadvantages. Semistructured storage technology is easier to deploy and much more promising to promote in a wider range than all-structured method. The combination of central and distributed data storage is more practical for regional data sharing. This analysis suggests that semistructural data storage technology and the combination of central and distributed data storages are efficient and fit well with the current situation in China.