1. Genes involved in systemic and arterial bed dependent atherosclerosis - Tampere Vascular Study
- Author
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Levula, Mari, Oksala, Niku, Airla, Nina, Laaksonen, Reijo, Kähönen, Mika, Pelto-Huikko, Markku, Lehtimäki, Terho, Lääketieteen yksikkö - School of Medicine, and University of Tampere
- Subjects
Biolääketieteet - Biomedicine - Abstract
Background Atherosclerosis is a complex disease with hundreds of genes influencing its progression. In addition, the phenotype of the disease varies significantly depending on the arterial bed. Methodology/Principal Findings We characterized the genes generally involved in human advanced atherosclerotic (AHA type V–VI) plaques in carotid and femoral arteries as well as aortas from 24 subjects of Tampere Vascular study and compared the results to non-atherosclerotic internal thoracic arteries (n=6) using genome-wide expression array and QRT-PCR. In addition we determined genes that were typical for each arterial plaque studied. To gain a comprehensive insight into the pathologic processes in the plaques we also analyzed pathways and gene sets dysregulated in this disease using gene set enrichment analysis (GSEA). According to the selection criteria used (>3.0 fold change and p-value
- Published
- 2012