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Avian influenza A(H5N8) virus has caused major epizootics in Europe since 2016. We conducted virologic analysis of aerosol and dust collected on poultry farms in France during 2020-2021. Our results suggest dust contributes to viral dispersal, even early in an outbreak, and could be a valuable surveillance tool.

Excavations in 2014–15 in the vicinity of Bucklow Hill revealed two clusters of cremated human remains, one focused on a ring-ditch, the other on a similar but destroyed monument. Ephemeral traces ...

Fusion genes are structural variants that arise when the coding region of two previously independent genes become joined together; fusion genes can be a major driving cause of cancer development. Many gene fusion events have been classified as clinically-relevant and are targets for both diagnostic applications, such as TMPRSS2-ERG in prostate cancer, and therapeutic applications, such as CD74-ROS1 and EML4-ALK in non-small cell lung cancer. Given the potential clinical benefits of early detection, there is significant interest in developing highly sensitive and accurate diagnostic assays to detect cancer using these gene fusions as biomarkers. A significant barrier to the development of these diagnostic assays is the lack of a reliable and renewable sample source harboring gene fusions of interest for use in assay development and analytical validation. Here, we describe the development and performance of a new fusion reference material: the Twist Pan-cancer RNA Fusion Control, a highly-multiplexed positive control designed to be spiked into a selected RNA background or as a stand-alone positive control. The Twist Pan-cancer RNA Fusion Control provides a wide selection of 80+ common and curated cancer targets for analytical validation and assay development. The synthetic RNAs are designed centered around the known and documented fusion sites with 750 nt of RNA 5′- of and 3′- of the fusion junction, suitable for short read sequencing and qPCR experiments. Pooled synthetic fusion RNAs are quantified at known molar ratios, NGS QC’d for uniformity, and ddPCR’d to establish a highly precise pool concentration. Finally, in fusion detection NGS experiments, we observe over a 95% recall rate of fusion events. The Pan-cancer RNA Fusion Control is designed to serve as a spike-in or stand-alone positive control and specifically pairs well with a clinically-relevant target enrichment (TE) panel within the Twist Targeted Enrichment for Gene Expression solution. This control sample positive for RNA fusions can be applied in both qPCR and NGS workflows to validate panel/probe sets, establish limits of detection, and monitor ongoing assay performance. The Twist Pan-cancer RNA Fusion Control provides a valuable one-stop solution to assay developers seeking reference materials for a wide array of cancer-associated fusion transcripts. For Research Use Only. Not for use in diagnostic procedures. Citation Format: Patrick Daniel Cherry, Jason Corwin, Kit Fuhrman, Jean Challacombe, Derek Murphy, Esteban Toro. Twist pan-cancer synthetic RNA fusion control for assay development [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 247.

Introduction: The objective of this paper is to demonstrate techniques on how to improve hip flexibility and mobility, especially for track and field athletes. It also seeks to explain the underlying importance of hip flexibility and mobility. When athlete’s hips are stiff and inflexible, muscle imbalance may occur and increase the risk of injury. Muscle imbalance in the hip often causes knee and hip pain, due to the hip flexors and quadriceps overworking in order to compensate for weaker muscles. The hip mobility and flexibility exercises illustrated here are designed to significantly improve the range of motion (ROM) of the hips. Enhanced ROM can improve motor performance, skill execution, and even prevent injury. Excellent hip extension improves the ability to assist the hip in developing power. Methods: 9 Hip Mobility and 6 Hip Flexibility exercises are described in this paper. The exercises are to be performed 3× per week with at least 24 hours break in-between to achieve optimum results. Conclusion: This paper sought to outline the importance of hip mobility and flexibility, in particular for non-contact-sport athletes (such as those in track and field), and their effects on athletic performance and injury prevention. After proximately 6 weeks, the ROM of the hip will be expected to improve significantly.

Zusammenfassung Der Pferdesport erfreut sich weltweit wachsender Beliebtheit. Sturze vom Pferd kommen zwar haufig vor, fuhren aber eher selten zu schweren Verletzungen. Es muss grundsatzlich zwischen Unfallen wahrend der Ausubung des Pferdesports und dem blosen Umgang mit dem Pferd differenziert werden, da hier unterschiedliche Verletzungsmuster zu beachten sind. Im Rahmen der Unfallpravention kommen der Aufklarung uber potenzielle Unfallrisiken sowie der fundierten Ausbildung von Reiter und Pferd besondere Bedeutung zu.

Supplemental material, sj-docx-15-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-6-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-11-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-28-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-8-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-23-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-25-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-19-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-29-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-26-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-2-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-24-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-25-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-26-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-22-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-17-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-30-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-1-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-6-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-9-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-18-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-22-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-13-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-17-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-30-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-27-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-23-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-21-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-3-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-10-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-24-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-12-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-15-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-10-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-12-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-21-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-4-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-13-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-16-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-7-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-4-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-11-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-8-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology

Supplemental material, sj-docx-19-tpx-10.1177_01926233221103181 for A Comparison of Historical Control Data From Cynomolgus Macaques (Macaca Fascicularis) of Chinese, Cambodian, and Vietnamese Origin by Molly Liepnieks, Caitlyn Carter, Michael J. Caruso, Zac Lloyd, Michael Muzyka and Daniel Patrick in Toxicologic Pathology