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International audience; Chromium disilicide CrSi2 is an interesting compound for thermoelectric applications. In order to decrease its lattice thermal conductivity that mainly limits its performance, two main routes have been investigated thus far, either increasing the unit cell disorder or creating multiple interfaces through nanostructuring. Here, we explore the effect of the latter route by investigating in detail the effect of the grain size reduction and residual microstrains on the lattice dynamics and lattice thermal conductivity. The phonon dispersion curves were measured on single-crystalline CrSi2 using inelastic neutron scattering, while the generalized vibrational density of states (GVDOS) was determined on bulk and nanostructured CrSi2. All experimental results are consistent with our density functional theory calculations. The results show that the optical phonons contribute from 50 to 70% of the lattice thermal conductivity. The temperature variations in the GVDOS of CrSi2 follow a quasi-harmonic behavior, which explains its rather large lattice thermal conductivity measured on the single-crystalline specimen. In addition, the GVDOS of nanocrystalline CrSi2 evidences a spectral weight transfer at low energy, which is related to a decrease in both the Debye temperature and the sound velocities that may be ascribed to an increase in both the interface density and internal strain. These observations explain the strong decrease in the lattice thermal conductivity observed in our prior study on densified nanostructured CrSi2 pellets.

The vertebrate CNS is surrounded by the meninges, a protective barrier comprised of the outer dura mater and the inner leptomeninges, which includes the arachnoid and pial layers. While the dura mater contains lymphatic vessels, no conventional lymphatics have been found within the brain or leptomeninges. However, non-lumenized cells called Brain/Mural Lymphatic Endothelial Cells or Fluorescent Granule Perithelial cells (muLECs/BLECs/FGPs) that share a developmental program and gene expression with peripheral lymphatic vessels have been described in the meninges of zebrafish. Here we identify a structurally and functionally similar cell type in the mammalian leptomeninges that we name Leptomeningeal Lymphatic Endothelial Cells (LLEC). As in zebrafish, LLECs express multiple lymphatic markers, containing very large, spherical inclusions, and develop independently from the meningeal macrophage lineage. Mouse LLECs also internalize macromolecules from the cerebrospinal fluid, including Amyloid-β, the toxic driver of Alzheimer’s disease progression. Finally, we identify morphologically similar cells co-expressing LLEC markers in human post-mortem leptomeninges. Given that LLECs share molecular, morphological, and functional characteristics with both lymphatics and macrophages, we propose they represent a novel, evolutionary conserved cell type with potential roles in homeostasis and immune organization of the meninges. Electronic supplementary material The online version of this article (10.1007/s00401-019-02091-z) contains supplementary material, which is available to authorized users.

The heavy-fermion compound CeCu_{6-x}Au_{x} has become a model system for unconventional magnetic quantum criticality. For small Au concentrations 0≤x0.16, the compound undergoes a structural transition from orthorhombic to monoclinic crystal symmetry at a temperature T_{s} with T_{s}→0 for x≈0.15. Antiferromagnetic order sets in close to x≈0.1. To shed light on the interplay between quantum-critical magnetic and structural fluctuations we performed neutron-scattering and thermodynamic measurements on samples with 0≤x≤0.3. The resulting phase diagram shows that the antiferromagnetic and monoclinic phase coexist in a tiny Au concentration range between x≈0.1 and 0.15. The application of hydrostatic and chemical pressure allows us to clearly separate the transitions from each other and to explore a possible effect of the structural transition on the magnetic quantum-critical behavior. Our measurements demonstrate that at low temperatures the unconventional quantum criticality exclusively arises from magnetic fluctuations and is not affected by the monoclinic distortion.

FeCrAs displays an unusual electrical response that is neither metallic in character nor divergent at low temperatures, as expected for an insulating response, and therefore it has been termed a "nonmetal-metal". We carried out neutron scattering experiments on powder and single crystal samples to study the magnetic dynamics and critical fluctuations in FeCrAs. Magnetic neutron diffraction measurements find Cr3+ magnetic order setting in at 115 K with the mean-field critical exponent. Neutron spectroscopy, however, observes gapless stiff magnetic fluctuations emanating from magnetic positions with propagation wave vector q_0=(1/3,1/3), which persists up to at least 80 meV. The magnetism in FeCrAs therefore displays a response which resembles that of itinerant magnets at high energy transfers, such as chromium alloys. We suggest that the presence of stiff high-energy spin fluctuations is the origin of the unusual temperature dependence of the resistivity., 7 pages, 5 figures

The energy gap for electronic excitations is one of the most important characteristics of the superconducting state, as it directly refects the pairing of electrons. In the copper-oxide high temperature superconductors (HTSCs), a strongly anisotropic energy gap, which vanishes along high symmetry directions, is a clear manifestation of the d-wave symmetry of the pairing. There is, however, a dramatic change in the form of the gap anisotropy with reduced carrier concentration (underdoping). Although the vanishing of the gap along the diagonal to the square Cu-O bond directions is robust, the doping dependence of the large gap along the Cu-O directions suggests that its origin might be different from pairing. It is thus tempting to associate the large gap with a second order parameter distinct from superconductivity. We use angle-resolved photoemission spectroscopy (ARPES) to show that the two-gap behavior, and the destruction of well defined electronic excitations, are not universal features of HTSCs, and depend sensitively on how the underdoped materials are prepared. Depending on cation substitution, underdoped samples either show two-gap behavior or not. In contrast, many other characteristics of HTSCs, such as the domelike dependence of Tc on doping, long-lived excitations along the diagonals to the Cu-O bonds, energy gap at the antinode (crossing of the underlying Fermi surface and the (pi, 0)-(pi, pi) line) decreasing monotonically with doping, while persisting above Tc (the pseudogap), are present in all samples, irrespective of whether they exhibit two-gap behavior or not. Our results imply that universal aspects of high Tc superconductivity are relatively insensitive to differences in the electronic states along the Cu-O bond directions., Accepted for publication at PNAS

Supplemental Digital Content is available in the text., The role of smooth muscle endothelinB (ETB) receptors in regulating vascular function, blood pressure (BP), and neointimal remodeling has not been established. Selective knockout mice were generated to address the hypothesis that loss of smooth muscle ETB receptors would reduce BP, alter vascular contractility, and inhibit neointimal remodeling. ETB receptors were selectively deleted from smooth muscle by crossing floxed ETB mice with those expressing cre-recombinase controlled by the transgelin promoter. Functional consequences of ETB deletion were assessed using myography. BP was measured by telemetry, and neointimal lesion formation induced by femoral artery injury. Lesion size and composition (day 28) were analyzed using optical projection tomography, histology, and immunohistochemistry. Selective deletion of ETB was confirmed by genotyping, autoradiography, polymerase chain reaction, and immunohistochemistry. ETB-mediated contraction was reduced in trachea, but abolished from mesenteric veins, of knockout mice. Induction of ETB-mediated contraction in mesenteric arteries was also abolished in these mice. Femoral artery function was unaltered, and baseline BP modestly elevated in smooth muscle ETB knockout compared with controls (+4.2±0.2 mm Hg; P

Parent compounds of Fe-based superconductors undergo a structural phase transition from a tetragonal to an orthorhombic structure. We investigated the temperature dependence of the frequencies of TA phonons that extrapolate to the shear vibrational mode at the zone center, which corresponds to the orthorhombic deformation of the crystal structure at low temperatures in ${\mathrm{BaFe}}_{2}{\mathrm{As}}_{2}$ and ${\mathrm{SrFe}}_{2}{\mathrm{As}}_{2}$. We found that acoustic phonons at small wave vectors soften gradually towards the transition from high temperatures, tracking the increase of the size of slowly fluctuating magnetic domains. On cooling below the transition to base temperature the phonons harden, following the square of the magnetic moment (which we find is proportional to the anisotropy gap). Our results provide evidence for close correlation between magnetic and phonon properties in Fe-based superconductors.

Resume Les antiarythmiques ont une efficacite et des effets secondaires qui varient selon les molecules et la classe pharmacologique a laquelle ils appartiennent. Leur utilisation en medecine d'urgence prehospitaliere et hospitaliere repose sur des regles precises, et ce d'autant plus que leur marge therapeutique est etroite. Parmi ces regles, les principales sont l'appreciation rapide du retentissement hemodynamique, l'identification precise du trouble du rythme, la recherche du facteur declenchant et/ou favorisant, la connaissance de la pharmacocinetique de la molecule utilisee et le respect de leurs associations. Parmi les molecules injectables, l'adenosine triphosphate (Striadyne ® ) garde une place de choix dans le traitement des tachycardies jonctionnelles, le sotalol et l'amiodarone dans le traitement des tachycardies ventriculaires (en respectant rigoureusement les precautions d'injections). Les associations d'antiarythmiques sont a proscrire dans l'urgence. La cardioversion par choc electrique externe est reservee aux etats de choc et/ou aux echecs du traitement medicamenteux. Le respect des regles de prescription permet, dans une situation precaire aux urgences ou en prehospitalier, de passer un cap avant de confier le patient au cardiologue pour la suite de l'exploration et du traitement de fond de ce trouble du rythme.

Tissue resident macrophages have vital homeostatic roles in many tissues but their roles are less well defined in the heart. The present study aimed to identify the density, polarisation status and distribution of macrophages in the healthy murine heart and to investigate their ability to respond to immune challenge. Histological analysis of hearts from CSF-1 receptor (csf1-GFP; MacGreen) and CX3CR1 (Cx3cr1(GFP/+)) reporter mice revealed a sparse population of GFP positive macrophages that were evenly distributed throughout the left and right ventricular free walls and septum. F4/80+CD11b+ cardiac macrophages, sorted from myocardial homogenates, were able to phagocytose fluorescent beads in vitro and expressed markers typical of both 'M1' (IL-1β, TNF and CCR2) and 'M2' activation (Ym1, Arg 1, RELMα and IL-10), suggesting no specific polarisation in healthy myocardium. Exposure to Th2 challenge by infection of mice with helminth parasites Schistosoma mansoni, or Heligmosomoides polygyrus, resulted in an increase in cardiac macrophage density, adoption of a stellate morphology and increased expression of Ym1, RELMα and CD206 (mannose receptor), indicative of 'M2' polarisation. This was dependent on recruitment of Ly6ChighCCR2+ monocytes and was accompanied by an increase in collagen content. In conclusion, in the healthy heart resident macrophages are relatively sparse and have a phagocytic role. Following Th2 challenge this population expands due to monocyte recruitment and adopts an 'M2' phenotype associated with increased tissue fibrosis.

We report an inelastic neutron scattering investigation of phonons with energies up to 159 meV in the conventional superconductor YNi(2)B(2)C. Using the sweep mode, a newly developed time-of-flight technique involving the continuous rotation of a single crystal specimen, allowed us to measure a four-dimensional volume in (Q, E) space and, thus, determine the dispersion surface and linewidths of the A(1g) (≈102 meV) and A(u) (≈159 meV) type phonon modes over the whole Brillouin zone. Despite of having linewidths of Γ=10 meV, A(1g) modes do not strongly contribute to the total electron-phonon coupling constant λ. However, experimental linewidths show a remarkable agreement with ab initio calculations over the complete phonon energy range, demonstrating the accuracy of such calculations in a rare comparison to a comprehensive experimental data set.

We report an inelastic neutron scattering investigation of phonons with energies up to 159 meV in the conventional superconductor YNi(2)B(2)C. Using the sweep mode, a newly developed time-of-flight technique involving the continuous rotation of a single crystal specimen, allowed us to measure a four-dimensional volume in (Q, E) space and, thus, determine the dispersion surface and linewidths of the A(1g) (≈102 meV) and A(u) (≈159 meV) type phonon modes over the whole Brillouin zone. Despite of having linewidths of Γ=10 meV, A(1g) modes do not strongly contribute to the total electron-phonon coupling constant λ. However, experimental linewidths show a remarkable agreement with ab initio calculations over the complete phonon energy range, demonstrating the accuracy of such calculations in a rare comparison to a comprehensive experimental data set.

We report an inelastic neutron scattering study of acoustic phonons in the charge and orbitally ordered bilayer manganite LaSr(2)Mn(2)O(7). For excitation energies less than 15 meV, we observe an abrupt increase (decrease) of the phonon energies (linewidths) of a transverse acoustic phonon branch at q = (h, h, 0), h ≤ 0.3, upon entering the low temperature charge and orbital ordered state (T(COO) = 225 K). This indicates a reduced electron-phonon coupling due to a decrease of electronic states at the Fermi level leading to a partial removal of the Fermi surface below T(COO) and provides direct experimental evidence for a link between electron-phonon coupling and charge order in manganites.

We report inelastic neutron scattering measurements of the resonant spin excitations in Ba(1-x)K(x)Fe(2)As(2) over a broad range of electron band filling. The fall in the superconducting transition temperature with hole doping coincides with the magnetic excitations splitting into two incommensurate peaks because of the growing mismatch in the hole and electron Fermi surface volumes, as confirmed by a tight-binding model with s(±)-symmetry pairing. The reduction in Fermi surface nesting is accompanied by a collapse of the resonance binding energy and its spectral weight, caused by the weakening of electron-electron correlations.

We report an inelastic neutron scattering study of acoustic phonons in the charge and orbitally ordered bilayer manganite LaSr(2)Mn(2)O(7). For excitation energies less than 15 meV, we observe an abrupt increase (decrease) of the phonon energies (linewidths) of a transverse acoustic phonon branch at q = (h, h, 0), h ≤ 0.3, upon entering the low temperature charge and orbital ordered state (T(COO) = 225 K). This indicates a reduced electron-phonon coupling due to a decrease of electronic states at the Fermi level leading to a partial removal of the Fermi surface below T(COO) and provides direct experimental evidence for a link between electron-phonon coupling and charge order in manganites.

We report inelastic x-ray scattering measurements of the temperature dependence of phonon dispersion in the prototypical charge-density-wave (CDW) compound 2H-NbSe2. Surprisingly, acoustic phonons soften to zero frequency and become overdamped over an extended region around the CDW wave vector. This extended phonon collapse is dramatically different from the sharp cusp in the phonon dispersion expected from Fermi surface nesting. Instead, our experiments, combined with ab initio calculations, show that it is the wave vector dependence of the electron-phonon coupling that drives the CDW formation in 2H-NbSe2 and determines its periodicity. This mechanism explains the so far enigmatic behavior of CDW in 2H-NbSe2 and may provide a new approach to other strongly correlated systems where electron-phonon coupling is important.

We report inelastic x-ray scattering measurements of the temperature dependence of phonon dispersion in the prototypical charge-density-wave (CDW) compound 2H-NbSe2. Surprisingly, acoustic phonons soften to zero frequency and become overdamped over an extended region around the CDW wave vector. This extended phonon collapse is dramatically different from the sharp cusp in the phonon dispersion expected from Fermi surface nesting. Instead, our experiments, combined with ab initio calculations, show that it is the wave vector dependence of the electron-phonon coupling that drives the CDW formation in 2H-NbSe2 and determines its periodicity. This mechanism explains the so far enigmatic behavior of CDW in 2H-NbSe2 and may provide a new approach to other strongly correlated systems where electron-phonon coupling is important.

We report high-resolution inelastic x-ray measurements of the soft phonon mode in the charge-density-wave compound TiSe$_2$. We observe a complete softening of a transverse optic phonon at the L point, i.e. q = (0.5, 0, 0.5), at T ~ T_{CDW}. Renormalized phonon energies are observed over a large wavevector range $(0.3, 0, 0.5) \le \mathbf{q} \le (0.5, 0, 0.5)$. Detailed ab-initio calculations for the electronic and lattice dynamical properties of TiSe2 are in quantitative agreement with experimental frequencies for the phonon branch involving the soft mode. The observed broad range of renormalized phonon frequencies is directly related to a broad peak in the electronic susceptibility stabilizing the charge-density-wave ordered state. Our analysis demonstrates that a conventional electron-phonon coupling mechanism can explain a structural instability and the charge-density-wave order in TiSe_2 although other mechanisms might further boost the transition temperature.

We report a high resolution resonant inelastic x-ray scattering investigation of the bilayer manganites La$_{2-2x}$Sr$_{1+2x}$Mn$_2$O$_7$ with $x = 0.36$ and $0.5$. The momentum dependence along the crystallographic $(110)$ direction for energy losses $1\,\rm{eV} \leq \Delta E \leq 15\,\rm{eV}$ has been measured in detail with the data analysis focusing on the energy loss region $1\,\rm{eV} \leq \Delta E \leq 5\,\rm{eV}$, which includes a strong peak located at $\Delta E \approx 2\,\rm{eV}$. We observe a clear dispersion of up to $0.5\,\rm{eV}$ in the measured $\textbf{q}$ range, which is direct evidence of the non-local character of this excitation. Further, we found that the intensity in this low energy region strongly depends on both the reduced wave vector $\textbf{q} = (h, h, 0)$, $h = 0.1 - 0.5$, and temperature, i.e. different ordered phases. Results can be explained via an intersite $d-d$ charge transfer excitation, proposed for pseudo-cubic manganites, where the hopping rate is strongly increased (decreased) by ferromagnetic (antiferromagnetic) alignment of neighboring in-plane Mn ion core spins.

The magnetic structure for the recently synthesized iron-arsenide compound ${\text{CaFe}}_{4}{\text{As}}_{3}$ has been studied by neutron-powder diffraction. Long-range magnetic order is detected below 85 K, with an incommensurate modulation described by the propagation vector $k=(0,\ensuremath{\delta},0)$, $\ensuremath{\delta}\ensuremath{\sim}0.39$. Below $\ensuremath{\sim}25\text{ }\text{K}$, our measurements detect a first-order phase transition where $\ensuremath{\delta}$ locks into the commensurate value $\frac{3}{8}$. A model of the magnetic structure is proposed for both temperature regimes, based on Rietveld refinements of the powder data and symmetry considerations. The structures correspond to longitudinal spin-density waves with magnetic moments directed along the $b$ axis. A Landau analysis captures the change in thermodynamic quantities observed at the two magnetic transitions, in particular, the drop in resistivity at the lock-in transition.

High-resolution x-ray scattering measurements on single crystal Tb2Ti2O7 reveal finite structural correlations at low temperatures. This geometrically frustrated pyrochlore is known to exhibit a spin-liquid or cooperative paramagnetic state at temperatures below approximately 20 K. Parametric studies of structural Bragg peaks appropriate to the Fd3[over ]m space group of Tb2Ti2O7 reveal substantial broadening and peak intensity reduction in the temperature regime 20 K to 300 mK. We also observe a small, anomalous lattice expansion on cooling below a density maximum at approximately 18 K. These measurements are consistent with the development of fluctuations above a cooperative Jahn-Teller, cubic-tetragonal phase transition at very low temperatures.

High-resolution, inelastic neutron scattering measurements on SrCu2(BO3)2, a realization of the Shastry-Sutherland model for two-dimensional Heisenberg antiferromagnets, reveal the dispersion of the three single triplet excitations continuously across the (H,0) direction within its tetragonal basal plane. These measurements also show distinct Q dependencies for the single and multiple triplet excitations, and that these excitations are largely dispersionless perpendicular to this plane. The temperature dependence of the intensities of these excitations is well described as the complement of the dc susceptibility of SrCu2(BO3)2.

We have performed measurements of the critical neutron scattering on CsCo0.83Mg0.17Br3, a dilute stacked triangular lattice (STL) Ising antiferromagnet (AF). A two component line shape associated with the critical fluctuations appears at a temperature coincident with T(N1) observed in pure CsCoBr3. Such scattering is indicative of fluctuations in prototypical random field Ising model (RFIM) systems. The random field domain state arises in this case due to geometrical frustration within the STL Ising AF, which gives rise to a three sublattice Néel state, in which one sublattice is disordered. Magnetic vacancies nucleate AF domains in which the vacancies reside on the disordered sublattice thereby generating a RFIM state in the absence of an applied magnetic field.

We present a study of the local environment of the Co atom in single crystalline CoxNbSe2, x = 0.013, via Extended X-ray Absorption Fine Structure (EXAFS) measurements at the Co K-edge (7.7 keV) at various temperatures. Co intercalation quickly suppresses superconductivity and the charge-density wave (CDW) present in pure NbSe2. In order to study the effect of impurities on superconducting and CDW states one has to verify the random distribution of the intercalated atoms in contrast to possible clustering which could lead to additional, e.g. magnetic, interactions in the case of Co intercalation. Our measurements show that the Co atoms are indeed randomly distributed in Co0.013NbSe2.

A charge-density wave (CDW) state has a broken symmetry described by a complex order parameter with an amplitude and a phase. The conventional view, based on clean, weak-coupling systems, is that a finite amplitude and long-range phase coherence set in simultaneously at the CDW transition temperature T$_{cdw}$. Here we investigate, using photoemission, X-ray scattering and scanning tunneling microscopy, the canonical CDW compound 2H-NbSe$_2$ intercalated with Mn and Co, and show that the conventional view is untenable. We find that, either at high temperature or at large intercalation, CDW order becomes short-ranged with a well-defined amplitude that impacts the electronic dispersion, giving rise to an energy gap. The phase transition at T$_{cdw}$ marks the onset of long-range order with global phase coherence, leading to sharp electronic excitations. Our observations emphasize the importance of phase fluctuations in strongly coupled CDW systems and provide insights into the significance of phase incoherence in `pseudogap' states., main manuscript plus supplementary information