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1. External validation of the PAGE-B score for HCC risk prediction in people living with HIV/HBV coinfection

Author

Bernard Surial, Adrià Ramírez Mena, Marie Roumet, Andreas Limacher, Colette Smit, Olivier Leleux, Amanda Mocroft, Marc van der Valk, Fabrice Bonnet, Lars Peters, Jürgen K. Rockstroh, Huldrych F. Günthard, Annalisa Berzigotti, Andri Rauch, Gilles Wandeler, I. Abela, K. Aebi-Popp, A. Anagnostopoulos, M. Battegay, E. Bernasconi, D.L. Braun, H.C. Bucher, A. Calmy, M. Cavassini, A. Ciuffi, G. Dollenmaier, M. Egger, L. Elzi, J. Fehr, J. Fellay, H. Furrer, C.A. Fux, H.F. Günthard, A. Hachfeld, D. Haerry, B. Hasse, H.H. Hirsch, M. Hoffmann, I. Hösli, M. Huber, D. Jackson-Perry, C.R. Kahlert, L. Kaiser, O. Keiser, T. Klimkait, R.D. Kouyos, H. Kovari, K. Kusejko, N. Labhardt, K. Leuzinger, Martinez de Tejada B, C. Marzolini, K.J. Metzner, N. Müller, J. Nemeth, D. Nicca, J. Notter, P. Paioni, G. Pantaleo, M. Perreau, A. Rauch, L. Salazar-Vizcaya, P. Schmid, R. Speck, M. Stöckle, P. Tarr, A. Trkola, G. Wandeler, M. Weisser, S. Yerly, M. van der Valk, S.E. Geerlings, A. Goorhuis, V.C. Harris, J.W. Hovius, B. Lempkes, F.J.B. Nellen, T. van der Poll, J.M. Prins, V. Spoorenberg, M. van Vugt, W.J. Wiersinga, F.W.M.N. Wit, C. Bruins, J. van Eden, I.J. Hylkema-van den Bout, A.M.H. van Hes, F.J.J. Pijnappel, S.Y. Smalhout, A.M. Weijsenfeld, N.K.T. Back, B. Berkhout, M.T.E. Cornelissen, R. van Houdt, M. Jonges, S. Jurriaans, C.J. Schinkel, K.C. Wolthers, H.L. Zaaijer, E.J.G. Peters, M.A. van Agtmael, R.S. Autar, M. Bomers, K.C.E. Sigaloff, M. Heitmuller, L.M. Laan, M. van den Berge, A. Stegeman, S. Baas, L. Hage de Looff, A. van Arkel, J. Stohr, B. Wintermans, M.J.H. Pronk, H.S.M. Ammerlaan, E.S. de Munnik, B. Deiman, A.R. Jansz, V. Scharnhorst, J. Tjhie, M.C.A. Wegdam, A. van Eeden, E. Hoornenborg, J. Nellen, W. Alers, L.J.M. Elsenburg, H. Nobel, M.E.E. van Kasteren, M.A.H. Berrevoets, A.E. Brouwer, B.A.F.M. de Kruijf-van de Wiel, A. Adams, M. Pawels-van Rijkevoorsel, A.G.M. Buiting, J.L. Murck, C. Rokx, A.A. Anas, H.I. Bax, E.C.M. van Gorp, M. de Mendonça Melo, E. van Nood, J.L. Nouwen, B.J.A. Rijnders, C.A.M. Schurink, L. Slobbe, T.E.M.S. de Vries-Sluijs, N. Bassant, J.E.A. van Beek, M. Vriesde, L.M. van Zonneveld, J. de Groot, J.J.A. van Kampen, M.P.G. Koopmans, J.C. Rahamat-Langendoen, J. Branger, R.A. Douma, A.S. Cents-Bosma, C.J.H.M. Duijf-van de Ven, E.F. Schippers, C. van Nieuwkoop, J. Geilings, S. van Winden, G. van der Hut, N.D. van Burgel, E.M.S. Leyten, L.B.S. Gelinck, F. Mollema, G.S. Wildenbeest, T. Nguyen, P.H.P. Groeneveld, J.W. Bouwhuis, A.J.J. Lammers, A.G.W. van Hulzen, S. Kraan, M.S.M. Kruiper, G.L. van der Bliek, P.C.J. Bor, S.B. Debast, G.H.J. Wagenvoort, A.H.E. Roukens, M.G.J. de Boer, H. Jolink, M.M.C. Lambregts, H. Scheper, W. Dorama, N. van Holten, E.C.J. Claas, E. Wessels, J.G. den Hollander, R. El Moussaoui, K. Pogany, C.J. Brouwer, D. Heida-Peters, E. Mulder, J.V. Smit, D. Struik-Kalkman, T. van Niekerk, O. Pontesilli, C. van Tienen, S.H. Lowe, A.M.L. Oude Lashof, D. Posthouwer, M.E. van Wolfswinkel, R.P. Ackens, K. Burgers, M. Elasri, J. Schippers, T.R.A. Havenith, M. van Loo, M.G.A. van Vonderen, L.M. Kampschreur, M.C. van Broekhuizen, null S, null Faber, A. Al Moujahid, G.J. Kootstra, C.E. Delsing, M. van der Burg-van de Plas, L. Scheiberlich, W. Kortmann, G. van Twillert, R. Renckens, J. Wagenaar, D. Ruiter-Pronk, F.A. van Truijen-Oud, J.W.T. Cohen Stuart, M. Hoogewerf, W. Rozemeijer, J.C. Sinnige, K. Brinkman, G.E.L. van den Berk, K.D. Lettinga, M. de Regt, W.E.M. Schouten, J.E. Stalenhoef, J. Veenstra, S.M.E. Vrouenraets, H. Blaauw, G.F. Geerders, M.J. Kleene, M. Knapen, M. Kok, I.B. van der Meché, A.J.M. Toonen, S. Wijnands, E. Wttewaal, D. Kwa, T.J.W. van de Laar, R. van Crevel, K. van Aerde, A.S.M. Dofferhoff, S.S.V. Henriet, H.J.M. ter Hofstede, J. Hoogerwerf, O. Richel, M. Albers, K.J.T. Grintjes-Huisman, M. de Haan, M. Marneef, M. McCall, D. Burger, E.H. Gisolf, M. Claassen, R.J. Hassing, G. ter Beest, P.H.M. van Bentum, M. Gelling, Y. Neijland, C.M.A. Swanink, M. Klein Velderman, S.F.L. van Lelyveld, R. Soetekouw, L.M.M. van der Prijt, J. van der Swaluw, J.S. Kalpoe, A. Wagemakers, A. Vahidnia, F.N. Lauw, D.W.M. Verhagen, M. van Wijk, W.F.W. Bierman, M. Bakker, R.A. van Bentum, M.A. van den Boomgaard, J. Kleinnijenhuis, E. Kloeze, A. Middel, D.F. Postma, H.M. Schenk, Y. Stienstra, M. Wouthuyzen-Bakker, A. Boonstra, H. de Jonge, M.M.M. Maerman, D.A. de Weerd, K.J. van Eije, M. Knoester, C.C. van Leer-Buter, H.G.M. Niesters, null T.Mudrikova, R.E. Barth, A.H.W. Bruns, P.M. Ellerbroek, M.P.M. Hensgens, J.J. Oosterheert, E.M. Schadd, A. Verbon, B.J. van Welzen, H. Berends, B.M.G. Griffioen-van Santen, I. de Kroon, F.M. Verduyn Lunel, A.M.J. Wensing, S. Zaheri, A.C. Boyd, D.O. Bezemer, A.I. van Sighem, C. Smit, M.M.J. Hillebregt, T.J. Woudstra, T. Rutkens, D. Bergsma, N.M. Brétin, K.J. Lelivelt, L. van de Sande, K.M. Visser.S.T. van der Vliet, F. Paling, L.G.M. de Groot-Berndsen, M. van den Akker, R. Alexander, Y. Bakker, A. El Berkaoui, M. Bezemer-Goedhart, E.A. Djoechro, M. Groters, L.E. Koster, C.R.E. Lodewijk, E.G.A. Lucas, L. Munjishvili, B.M. Peeck, C.M.J. Ree, R. Regtop, A.F. van Rijk, Y.M.C. Ruijs-Tiggelman, P.P. Schnörr, M.J.C. Schoorl, E.M. Tuijn, D.P. Veenenberg, E.C.M. Witte, I. Karpov, M. Losso, J. Lundgren, J. Rockstroh, I. Aho, L.D. Rasmussen, P. Novak, C. Pradier, N. Chkhartishvili, R. Matulionyte, C. Oprea, J.D. Kowalska, J. Begovac, J.M. Miró, G. Guaraldi, R. Paredes, L. Peters, J.F. Larsen, B. Neesgaard, N. Jaschinski, O. Fursa, D. Raben, D. Kristensen, A.H. Fischer, S.K. Jensen, T.W. Elsing, M. Gardizi, A. Mocroft, A. Phillips, J. Reekie, A. Cozzi-Lepri, A. Pelchen-Matthews, A. Roen, E.S. Tusch, W. Bannister, P. Bellecave, P. Blanco, F. Bonnet, S. Bouchet, D. Breilh, C. Cazanave, S. Desjardin, V. Gaborieau, A. Gimbert, M. Hessamfar, L. Lacaze-Buzy, D. Lacoste, M.E. Lafon, E. Lazaro, O. Leleux, F. Le Marec, G. Le Moal, D. Malvy, L. Marchand, P. Mercié, D. Neau, I. Pellegrin, A. Perrier, V. Petrov-Sanchez, M.O. Vareil, L. Wittkop, N. Bernard, D. Bronnimann H. Chaussade, D. Dondia, P. Duffau, I. Faure, P. Morlat, E. Mériglier, F. Paccalin, E. Riebero, C. Rivoisy, M.A. Vandenhende, L. Barthod, F.A. Dauchy, A. Desclaux, M. Ducours, H. Dutronc, A. Duvignaud, J. Leitao, M. Lescure, D. Nguyen, T. Pistone, M. Puges, G. Wirth, C. Courtault, F. Camou, C. Greib, J.L. Pellegrin, E. Rivière, J.F. Viallard, Y. Imbert, M. Thierry-Mieg, P. Rispal, O. Caubet, H. Ferrand, S. Tchamgoué, S. Farbos, H. Wille, K. Andre, L. Caunegre, Y. Gerard, F. Osorio-Perez, I. Chossat, G. Iles, M. Labasse-Depis, F. Lacassin, A. Barret, B. Castan, J. Koffi, N. Rouanes, A. Saunier, J.B. Zabbe, G. Dumondin, G. Beraud, M. Catroux, M. Garcia, V. Giraud, J.P. Martellosio, F. Roblot, T. Pasdeloup, A. Riché, M. Grosset, S. Males, C. Ngo Bell, C. Carpentier, Virology P. Bellecave, C. Tumiotto, G. Miremeont-Salamé, D. Arma, G. Arnou, M.J. Blaizeau, P. Camps, M. Decoin, S. Delveaux, F. Diarra, L. Gabrea, S. Lawson-Ayayi, E. Lenaud, D. Plainchamps, A. Pougetoux, B. Uwamaliya, K. Zara, V. Conte, M. Gapillout, Internal medicine, VU University medical center, Medical Microbiology and Infection Prevention, AII - Infectious diseases, CCA - Cancer biology and immunology, AII - Inflammatory diseases, AMS - Rehabilitation & Development, APH - Quality of Care, Pulmonary medicine, ACS - Pulmonary hypertension & thrombosis, Ethics, Law & Medical humanities, APH - Methodology, Midwifery Science, Amsterdam Reproduction & Development (AR&D), Infectious diseases, APH - Digital Health, APH - Personalized Medicine, APH - Aging & Later Life, APH - Global Health, Global Health, APH - Health Behaviors & Chronic Diseases, Center of Experimental and Molecular Medicine, General Internal Medicine, AII - Cancer immunology, Landsteiner Laboratory, Cardiology, ACS - Heart failure & arrhythmias, Obstetrics and Gynaecology, ARD - Amsterdam Reproduction and Development, Microbes in Health and Disease (MHD), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Global Health in the Global South (GHiGS), Institut de Recherche pour le Développement (IRD)- Bordeaux population health (BPH), and Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Hepatitis B virus, model validation, Hepatology, liver neoplasms, risk prediction models, liver cirrhosis, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], risk assessment, 610 Medicine & health, hepatocellular carcinoma, HIV infection, tenofovir, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, 610 Medizin und Gesundheit
Abstract

Background & Aims: HBV coinfection is common among people living with HIV (PLWH) and is the most important cause of hepatocellular carcinoma (HCC). While risk prediction tools for HCC have been validated in patients with HBV monoinfection, they have not been evaluated in PLWH. Thus, we performed an external validation of PAGE-B in people with HIV/HBV coinfection.Methods: We included data on PLWH from four European cohorts who were positive for HBsAg and did not have HCC before starting tenofovir. We estimated the predictive performance of PAGE-B for HCC occurrence over 15 years in patients receiving tenofovir-containing antiretroviral therapy. Model discrimination was assessed after multiple imputation using Cox regression with the prognostic index as a covariate, and by calculating Harrell's c-index. Calibration was assessed by comparing our cumulative incidence with the PAGE-B derivation study using Kaplan-Meier curves.Results: In total, 2,963 individuals with HIV/HBV coinfection on tenofovir-containing antiretroviral therapy were included. PAGE-B was Conclusions: For individuals with HIV/HBV coinfection, PAGE-B is a valid tool to determine the need for HCC screening. Impact and implications: Chronic HBV infection is the most important cause of hepatocellular carcinoma (HCC) among people living with HIV. Valid risk prediction may enable better targeting of HCC screening efforts to high-risk individuals. We aimed to validate PAGE-B, a risk prediction tool that is based on age, sex, and platelets, in 2,963 individuals with HIV/HBV coinfection who received tenofovir-containing antiretroviral therapy. In the present study, PAGE-B showed good discrimination, adequate calibration, and a cut-off of

Published
2023
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2. Improvement of Progressive Multifocal Leukoencephalopathy After Cidofovir Therapy in a Patient with a Destructive Polyarthritis

Author

O. Caubet, J L Pellegrin, Estibaliz Lazaro, E. Ellie, H. Fleury, J F Viallard, F. Camou, S. Eimer, and M. E. Lafon

Subjects
Microbiology (medical), Pathology, medicine.medical_specialty, viruses, Central nervous system, Organophosphonates, JC virus, Antibodies, Viral, medicine.disease_cause, Antiviral Agents, Cytosine, chemistry.chemical_compound, Refractory, Humans, Medicine, Aged, business.industry, Arthritis, Progressive multifocal leukoencephalopathy, Leukoencephalopathy, Progressive Multifocal, Brain, virus diseases, General Medicine, medicine.disease, JC Virus, Magnetic Resonance Imaging, White matter changes, Brain disease, Radiography, Treatment Outcome, Infectious Diseases, medicine.anatomical_structure, chemistry, Female, Polyarthritis, business, Cidofovir
Abstract

The human neurotropic JC virus (JCV) is responsible for progressive multifocal leukoencephalopathy (PML), an infectious demyelinating brain disease with major morbidity and mortality, usually refractory to treatment. We describe a PML in a 67-year-old woman with a destructive polyarthritis associated with anti-JO1 antibodies treated with corticosteroids. Although glucocorticoid therapy was maintained, administration of cidofovir improved the neurological condition. Our observation demonstrates the expanding clinical importance of JCV in systemic rheumatic diseases, particularly when immunosuppressive agents are used, and neurological symptoms or white matter changes on central nervous system imaging should arouse the suspicion of PML.

Published
2007
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3. Liens physiopathologiques entre maladie de Kikuchi et lupus : à propos de trois nouvelles observations

Author

C. Leyral, F. Camou, O. Caubet, Jean-François Viallard, C. Perlemoine, and Jean-Luc Pellegrin

Subjects
Gynecology, medicine.medical_specialty, Systemic disease, Kikuchi-Fujimoto Disease, Lupus erythematosus, business.industry, Gastroenterology, Histiocytic necrotizing lymphadenitis, medicine.disease, Connective tissue disease, Histiocytosis, Internal Medicine, medicine, business
Abstract

Resume Introduction. – La lymphadenite histiocytaire necrosante ou maladie de Kikuchi-Fujimoto est une entite anatomoclinique rare, d'etiologie inconnue dont le diagnostic est evoque chez un adulte jeune, frequemment de sexe feminin, presentant des adenopathies le plus souvent cervicales, une fievre et une asthenie. La confirmation est apportee par l'etude histologique ganglionnaire. L'evolution est spontanement favorable, mais certains cas peuvent reveler ou evoluer vers un lupus cutane ou systemique. Exegese. – Nous rapportons trois nouvelles observations de maladie de Kikuchi : un cas simulant un lupus systemique, un second avec une eruption cutanee de type lupique, et un cas severe avec syndrome d'activation macrophagique dans le cadre d'une primo-infection EBV revelant un lupus erythemateux systemique. Conclusion. – La recherche d'une maladie lupique, imposant un suivi clinicobiologique de ces patients, est donc necessaire et nous discutons les possibles liens physiopathologiques unissant ces deux entites.

Published
2005
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4. Maladie de Takayasu : un outil de quantification pour l’évaluation précoce de la réponse au traitement

Author

V. Meunier, Eric Laffon, O. Caubet, and Roger Marthan

Subjects
Radiological and Ultrasound Technology, Biophysics, Radiology, Nuclear Medicine and imaging
Abstract

Objectif Presenter un outil permettant d’evaluer precocement la reponse au traitement des maladies de Takayasu en TEP au 18-FDG, qui utilise le SUV moyenne a partir des N voxels les plus chauds (SUVmax-N), quelle que soit la situation anatomique de ces voxels sur les parois arterielles hypermetaboliques. Methode Illustree chez un patient, il s’agit de comparer les SUVmax-N des examens realises avant traitement versus apres 1 mois de traitement corticoide (0–1) et apres 1 mois versus apres 3 mois de traitement cortocoide (1–3), en utilisant les pourcentages de repetabilite des SUVmax-N donnes pour 95 % et 99,9 % de confiance. Resultats Il n’est pas observe de difference significative avec le SUVmax, c’est-a-dire relatif au voxel le plus chaud, pour les deux paires d’examens compares 0–1 et 1–3, avec 95 % de confiance. Par comparaison, une difference significative avec 99,9 % de confiance est observee pour les deux paires d’examens compares 0–1 et 1–3, lorsqu’un SUVmax-N moyennant les n = 4100 et 515 voxels les plus chauds est utilise (volume hypermetabolique total de 100,0 et 12,6 mL, respectivement). Conclusion La methode proposee s’avere fiable pour evaluer precocement la reponse au traitement dans la maladie de Takayasu. Son principe pourrait etre applique a d’autres situations cliniques d’evaluation therapeutique.

Published
2017
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5. Vasomotricité pulmonaire (2e partie): contrôle neurohumoral

Author

O Pillet, Y. Castaing, O. Caubet, and T Mayet

Subjects
Vasopressin, medicine.medical_specialty, Endothelium, business.industry, Superoxide, Critical Care and Intensive Care Medicine, chemistry.chemical_compound, medicine.anatomical_structure, Endocrinology, Atrial natriuretic peptide, chemistry, Internal medicine, Muscarinic acetylcholine receptor, Cholinergic system, Medicine, Serotonin, business, Histamine
Abstract

• - Neurologic control of lung vascular tone ◦ • Cholinergic system: - - mediators - - muscarinic receptors - - mechanisms of action ◦ • Non-adrenergic non-cholinergic system: - - definition - - mediators ◦ • Reflex mechanisms ◦ • Interactions between endothelium and neural mechanisms • - Humoral control of lung vascular tone ◦ • Atrial natriuretic peptide ◦ • Vasopressin ◦ • Angiotensin-II ◦ • Kinins ◦ • Histamine ◦ • Serotonin ◦ • Free radicals: - - hydrogen peroxide - - superoxide anion - - peroxinitrite

Published
2000
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6. Vasomotricité pulmonaire (1re partie): phénomènes ioniques et rôle de l'endothélium

Author

Y. Castaing, O Pillet, O. Caubet, and T Mayet

Subjects
medicine.hormone, medicine.medical_specialty, Vascular smooth muscle, Endothelium, Endoplasmic reticulum, chemistry.chemical_element, Calcium, Critical Care and Intensive Care Medicine, Potassium channel, Nitric oxide, Endothelial stem cell, Endothelins, chemistry.chemical_compound, Endocrinology, medicine.anatomical_structure, chemistry, Internal medicine, cardiovascular system, medicine
Abstract

Problems related to the study of pulmonary vasomotility - Constriction/dilation of the vascular smooth muscle: ionic mechanisms · Calcium movements: - through sarcoplasmic reticulum - through cytoplasmic membrane · Potassium channels · C-protein kinases · G-proteins · Cyclic nucleotids - The endothelium · Paracrine role of the endothelial cell: - nitric oxide - endothelium-derived hyperpolarizing factor - eicosanoids - endothelins · Endothelial metabolism of vasoactive peptides: - angiotensin-converting enzyme - neutral endopeptidase - endothelin-converting enzyme.

Published
2000
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7. Effects of red wine, tannic acid, or ethanol on glucose tolerance in non—insulin-dependent diabetic patients and on starch digestibility in vitro

Author

J. Masquelier, Vincent Rigalleau, O. Caubet, J. Aubertin, and Henri Gin

Subjects
Blood Glucose, Male, medicine.medical_specialty, Starch, Endocrinology, Diabetes and Metabolism, Wine, macromolecular substances, chemistry.chemical_compound, Endocrinology, Internal medicine, Tannic acid, medicine, Humans, Insulin, Glucose tolerance test, Meal, Ethanol, medicine.diagnostic_test, food and beverages, Glucose Tolerance Test, Middle Aged, Carbohydrate, Hydrolyzable Tannins, Diet, Postprandial, Diabetes Mellitus, Type 2, chemistry, Digestion, alpha-Amylases
Abstract

This study examines the effect of moderate intake of red wine, tannic acid, or ethanol during a meal in type 2 diabetic patients and the influence of tannic acid on the digestibility of starch by alpha-amylase. Thirty non-insulin-dependent diabetes mellitus (NIDDM) patients aged 53 +/- 6 years were studied (in vivo study) 10 of whom received red wine (200 mL), 10 tannic acid (150 mg), and 10 ethanol (16 g) with their midday meal (600 calories, 65 g carbohydrate, 20 g lipid, and 34 g protein). All patients were tested on two occasions (water or placebo v wine, alcohol, or tannic acid). The influence of tannic acid (0.25, 0.5, and 1 mg) on the digestibility of starch (100 mg) by alpha-amylase (100 U) was tested in vitro by sequential incubation at 37 degrees C (in vitro study). The maximum glucose excursion after lunch was 2.6 +/- 0.8 mmol/L at 90 minutes (T90) for water and 1.8 +/- 0.9 mmol/L at T90 for red wine taken with the meal. The values at T60 and T90 were significant (P < .01). Comparable results were obtained with tannic acid alone (nonalcoholic component of wine): the maximum glucose excursion after lunch was 2.76 +/- 0.9 mmol/L at T120 for placebo and 1.97 +/- 0.9 mmol/L at T90 for tannic acid (P < .01); no difference in glucose and insulin excursion was observed between water and ethanol. No interaction between tannic acid and starch was observed in the in vitro experiments, although after preincubation of alpha-amylase with tannic acid, digestion was slowed in a dose-dependent manner (6.1 +/- 1.1 minutes for 0.25 mg tannic acid and 13.1 +/- 1.59 minutes for 1 mg tannic acid). Drinking red wine with a meal did not increase blood glucose in NIDDM patients, and led to a slight decrease in some instances. The effect appeared to be mediated by the nonalcoholic compounds in wine such as tannic acid. Ethanol itself had no effect on plasma glucose or insulin levels.

Published
1999
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8. Bursite trochantérienne, enthésopathie pelvienne et maladie de Horton

Author

Jean-François Viallard, O. Caubet, C. Michaux, Pierre Duffau, C. Greib, Jean-Luc Pellegrin, and A. Lorléac’h

Subjects
musculoskeletal diseases, medicine.medical_specialty, Pathology, Pelvic girdle, Bursitis, medicine.diagnostic_test, business.industry, Enthesopathy, Gastroenterology, Magnetic resonance imaging, Pelvic girdle pain, medicine.disease, Polymyalgia rheumatica, Giant cell arteritis, immune system diseases, Internal Medicine, medicine, Radiology, medicine.symptom, skin and connective tissue diseases, Vasculitis, business
Abstract

Giant cell arteritis, a large-sized vessel vasculitis, may be associated with musculoskeletal proximal (polymyalgia rheumatica) or distal manifestations. A 68-year-old woman, who had inflammatory pelvic girdle pain, was diagnosed with giant cell arteritis and was successfully treated with corticosteroids. The magnetic resonance imaging and ultrasonography revealed a bilateral bursitis and pelvic girdle enthesopathy. Bursitis is the main anatomic lesion occurring in polymyalgia rheumatica and can be underlined by ultrasonography.

Published
2008
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9. [Trochanteric bursitis, pelvic enthesopathy and giant cell arteritis]

Author

A, Lorléac'h, P, Duffau, C, Michaux, C, Greib, O, Caubet, J-F, Viallard, and J-L, Pellegrin

Subjects
Treatment Outcome, Adrenal Cortex Hormones, Bursitis, Polymyalgia Rheumatica, Biopsy, Giant Cell Arteritis, Humans, Female, Hip Joint, Magnetic Resonance Imaging, Aged, Temporal Arteries, Ultrasonography
Abstract

Giant cell arteritis, a large-sized vessel vasculitis, may be associated with musculoskeletal proximal (polymyalgia rheumatica) or distal manifestations. A 68-year-old woman, who had inflammatory pelvic girdle pain, was diagnosed with giant cell arteritis and was successfully treated with corticosteroids. The magnetic resonance imaging and ultrasonography revealed a bilateral bursitis and pelvic girdle enthesopathy. Bursitis is the main anatomic lesion occurring in polymyalgia rheumatica and can be underlined by ultrasonography.

Published
2007

10. [Pathogenic links between Kikuchi's disease and lupus: a report of three new cases]

Author

C, Leyral, F, Camou, C, Perlemoine, O, Caubet, J L, Pellegrin, and J F, Viallard

Subjects
Adult, Diagnosis, Differential, Male, Humans, Lupus Erythematosus, Systemic, Female, Histiocytic Necrotizing Lymphadenitis
Abstract

Histiocytic necrotizing lymphadenitis or Kikuchi-Fujimoto's disease is a rare anatomoclinical entity whose etiology remains unknown. It is mainly reported in young adult female, presenting with cervical lymphadenopathies, fever and asthenia. The diagnosis is based on the histological examination of a lymph node biopsy. The disease course is usually uneventful, but sometimes Kikuchi-Fujimoto's disease can reveal or evolve into a cutaneous or a systemic lupus.We report three new cases of Kikuchi's disease: the first one mimicked a systemic lupus, the second one was associated with a lupus-like rash, and a the last one was a severe case with hemophagocytic syndrome and a primo-infection with Epstein-Barr virus revealing a systemic lupus erythematosus.Clinical and biological follow-up of patients presenting with Kikuchi's disease is necessary to look for an association with a lupus. We discuss the pathogenic links between Kikuchi's disease and lupus.

Published
2004

11. [Acute adrenal insufficiency due to bilateral adrenal hematoma following severe thrombopenia induced by low-molecular-weight heparin]

Author

O, Caubet, O, Pillet, A, Cherifi, T, Mayet, Y, Castaing, and J C, Favarel Garrigues

Subjects
Hematoma, Acute Disease, Anticoagulants, Humans, Female, Heparin, Low-Molecular-Weight, Middle Aged, Thrombocytopenia, Adrenal Insufficiency
Abstract

Bilateral adrenal hematoma is an uncommon cause of acute adrenal insufficiency. An association with thrombopenia induced by low-molecular-weight heparin even more so. Diagnosis is difficult as the clinical manifestations mimic septic shock.A 63-year-old woman developed acute adrenal insufficiency due to bilateral adrenal hematoma following severe thrombopenia induced by low-molecular-weight heparin prescribed after an orthopedic operation. Outcome was favorable.Acute adrenal insufficiency must be entertained as a possible diagnosis in patients with heparin-induced thrombopenia.

Published
1999

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