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The Marginal Ice Zone is a highly dynamic region where the atmosphere, ocean, waves and sea ice meet. Waves play a fundamental role in this coupled system, but progress in our understanding of wave-ice interactions is currently hindered by the lack of observations of sea ice properties in-situ. In this study we aim to estimate the ice thickness and effective elastic modulus of sea ice passively using observations of waves in ice. Specifically, we use three low-cost geophones deployed in triangular formation with sides of about 200 m on fast ice. The focus here is on three major wave events recorded, each consisting of initial high frequency vibrations with a frequency at around 10 Hz, followed by low frequency dispersive waves within a frequency range of 0.08-0.28 Hz. Based on the phase speed of the initial high frequency vibrations, we estimate the purely elastic effective modulus to be 4-4.5 GPa. By comparing the arrival times of the dispersive low frequency wave events to the dispersion relationship of waves in a thin elastic ice sheet we obtain estimates of the effective elastic modulus in the range of 0.4-0.7 GPa. This is close to the measured effective elastic modulus through cantilever experiments of 0.5 GPa but considerably smaller than the default value of 5.5 GPa currently in use in contemporary wave models. We could not, however, obtain explicit estimates of the ice thickness and effective modulus individually as their impacts on the shape of the dispersion relationship are similar in this frequency range. Distinction is only possible for dispersive wave events larger than about 1 Hz, such as for vibrations generated by (thermal) cracking, which are frequently observed in our dataset. With our results, we show that low-cost geophones can be used to estimate sea ice properties in fast ice and substantiate that this to be possible on very large ice floes as well.

Vascular endothelial growth factor (VEGF) is a potent angiogenic factor in human gliomas. VEGF-induced proteins in endothelial cells, tissue factor (TF), osteopontin (OPN) and αvβ3 integrin have been implicated as important molecules by which VEGF promotes angiogenesis in vivo. Sixty-eight gliomas were immunohistochemically stained with TF, VEGF, OPN and αvβ3 integrin antibody. Twenty-three tumours, six normal brains and nine glioma cell lines were evaluated for their mRNA expression of VEGF and TF by reverse transcription polymerase chain reaction analysis. The data indicated that TF as well as VEGF was a strong regulator of human glioma angiogenesis. First, TF expression in endothelial cells which was observed in 74% of glioblastomas, 54% of anaplastic astrocytomas and none of low-grade astrocytomas, correlated with the microvascular density of the tumours. Double staining for VEGF and TF demonstrated co-localization of these two proteins in the glioblastoma tissues. Second, there was a correlation between TF and VEGF mRNA expression in the glioma tissues. Third, glioma cell conditioned medium containing a large amount of VEGF up-regulated the TF mRNA expression in human umbilical vein endothelial cells. OPN and αvβ3 integrin, were also predominantly observed in the microvasculature of glioblastomas associated with VEGF expression. Microvascular expression of these molecules could be an effective antiangiogenesis target for human gliomas. © 2000 Cancer Research Campaign

Neutron capture therapy with a new boron-porphyrin compound was tested in a rat brain tumor model . Although the concentration of boron in the tumor was too low to elicit a therapeutic effect, prominent histopathologic changes, such as necrosis, congestion and bleeding were observed in the tumors of the rats administered the boron neutron capture therapy.

APSIPA ASC 2009: Asia-Pacific Signal and Information Processing Association, 2009 Annual Summit and Conference. 4-7 October 2009. Sapporo, Japan. Oral session: Infrastructure Software for Speech Processing (5 October 2009)., A statistical parametric approach to speech synthesis based HMMs has grown in popularity over the last few years. In this approach, spectrum, excitation, and duration of speech are simultaneously modeled by context-dependent HMMs, and speech waveforms are generated from the HMMs themselves. Since December 2002, we have publicly released an opensource software toolkit named "HMM-based speech synthesis system (HTS)" to provide a research and development toolkit for statistical parametric speech synthesis. This paper describes recent developments of HTS in detail, as well as future release plans.

Adult tethered cord syndrome presents with various neurological symptoms such as bladder/bowel disturbance, motor and sensory disturbance, and pain.1–7 A common bowel disturbance is constipation and incontinence, which may recover depending on the severity or duration of the symptoms.2,3 In adult tethered cord syndrome, recovery of bladder disturbance is generally only seen in patients with a relatively short clinical history; therefore early diagnosis and treatment are essential to achieve a good functional recovery. We present a rare case of a patient who had suffered from refractory diarrhoea for years without a definite diagnosis and who was finally found to have tethered cord syndrome after bladder symptoms became apparent. A 22 year old woman was admitted to our department of gastroenterology with a complaint of severe diarrhoea which had been occurring …

The Neutron Beam Facility at JRR-4 enables us to carry out boron neutron capture therapy with epithermal neutron beam. In order to make treatment plans for performing the epithermal neutron beam BNCT, it is necessary to estimate radiation doses in a patient's head in advance. The JAERI Computational Dosimetry System (JCDS), which can estimate distributions of radiation doses in a patient's head by simulating in order to support the treatment planning for epithermal neutron beam BNCT, was developed. JCDS is a software that creates a 3-dimentional head model of a patient by using CT and MRI images, and that generates a input data file automatically for calculation of neutron flux and gamma-ray dose distributions in the brain with the Monte Carlo code MCNP, and that displays these dose distributions on the head model for dosimetry by using the MCNP calculation results. JCDS has any advantages as follows; By using CT data and MRI data which are medical images, a detail three-dimensional model of patient's head is able to be made easily. The three-dimensional head image is editable to simulate the state of a head after its surgical processes such as skin flap opening and bone removal in the BNCT with craniotomy that are being performed in Japan. JCDS can provide information for the Patient Setting System which can support to set the patient to an actual irradiation position swiftly and accurately. This report describes basic design of JCDS and functions in several processing, calculation methods, characteristics and performance of JCDS.

The surviving curve and the biological effectiveness factor of dose components generated in boron neutron capture therapy (BNCT) were separately determined in neutron beams at Japan Research Reactor No.4. Surviving fraction of V79 Chinese hamster cell with or without sup 1 sup 0 B was obtained using an epithermal neutron beam (ENB), a mixed thermal-epithermal neutron beam (TNB-1), and a thermal neutron beam (TNB-2), which were used or planned to use for BNCT clinical trial. The cell killing effect of these neutron beams with or without the presence of sup 1 sup 0 B depended highly on the neutron beam used, according to the epithermal and fast neutron content in the beam. The biological effectiveness factor values of the boron capture reaction for ENB, TNB-1 and TNB-2 were 3.99+-0.24, 3.04+-0.19 and 1.43+-0.08, respectively. The biological effectiveness factor values of the high-LET dose components based on the hydrogen recoils and the nitrogen capture reaction were 2.50+-0.32, 2.34+-0.30 and 2.17+-0.28 for ENB, TNB-1 and TNB-2, respectively. The biological effectiveness factor values of the neutron and photon components were 1.22+-0.16, 1.23+-0.16 and 1.21+-0.16, respectively. The depth function of biological effectiveness factor in water phantom and the difference in biological effectiveness factor among boron compounds were also determined. The experimental determination of biological effectiveness factor outlined in this paper is applicable to the dose calculation for each dose component of the neutron beams and contribute to an accurate biological effectiveness factor as comparison with a neutron beam at a different facility employed in ongoing and planned BNCT clinical trials.

A patient who had previously undergone resection of a malignant glioma followed by radiation therapy was found to have a focus of a high accumulation of thallous chloride Tl 201 on single-photon emission CT scans, suggesting recurrent tumor. Resection of this area was performed and the specimen showed radiation necrosis, including such reactive changes as reactive astrocytes and lymphocytes in the necrotic tissue. This case illustrates a diagnostic pitfall in the use of 201Tl single-photon emission CT for distinguishing radiation necrosis from recurrent tumor in patients treated for malignant glioma.

An extensive study has been made on the antitumor activity of several iridoid glycosides and their aglycones in mice bearing the experimental tumor leukemia P388. Most of the aglycones were found to be active. Among them, scadoside methyl ester aglycone (SMEH) showed the most potent activity, and it was furhter tested against several kinds of experimental tumor. None of the glucosides showed any activity. Our observations suggest that the hemiacetal structure of iridoid aglycones plays a significant role in the antitumor activity, as in the case of the antimicrobial activity reported previously.