1. Pregnancies Complicated by Familial Hypertriglyceridemia: A Case Report
- Author
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Guillermo J. Valenzuela, Suzanne Cao, NhuChi Dao, and Kristina Roloff
- Subjects
030213 general clinical medicine ,Pediatrics ,medicine.medical_specialty ,Diabetic ketoacidosis ,medicine.medical_treatment ,familial hypertriglyceridemia ,pancreatitis ,Case Report ,lcsh:Gynecology and obstetrics ,03 medical and health sciences ,0302 clinical medicine ,Diabetes mellitus ,medicine ,Gemfibrozil ,lcsh:RG1-991 ,Pregnancy ,030219 obstetrics & reproductive medicine ,business.industry ,Insulin ,Hypertriglyceridemia ,digestive, oral, and skin physiology ,Obstetrics and Gynecology ,nutritional and metabolic diseases ,medicine.disease ,Familial hypertriglyceridemia ,fetal demise ,gemfibrozil ,Pediatrics, Perinatology and Child Health ,Pancreatitis ,lipids (amino acids, peptides, and proteins) ,business ,preterm delivery ,medicine.drug - Abstract
Background Although rare, familial hypertriglyceridemia can cause acute and life-threatening complications in pregnancy. Cases The first patient's pregnancy was complicated by multiple admissions for pancreatitis due to hypertriglyceridemia and noncompliance with gemfibrozil. In her second pregnancy, she was compliant with gemfibrozil and only experienced pancreatitis episodes toward the end of pregnancy. The second patient had diabetes mellitus and familial hypertriglyceridemia. She required multiple hospitalizations for diabetic ketoacidosis secondary to insulin noncompliance. In both pregnancies, she was compliant with gemfibrozil and had no complications related to hypertriglyceridemia. Conclusion Treatment with gemfibrozil in pregnancies complicated by hypertriglyceridemia may prevent complications without adverse maternal or fetal effects and could be considered in treating pregnant patients with severe hypertriglyceridemia. These cases also demonstrate the importance of medication compliance in the prevention of poor outcomes.
- Published
- 2018