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1. Correction: PD-L1 in small bowel adenocarcinoma is associated with etiology and tumor-infiltrating lymphocytes, in addition to microsatellite instability (Modern Pathology, (2020), 33, 7, (1398-1409), 10.1038/s41379-020-0497-0)

Author

Giuffrida, P., Arpa, G., Grillo, F., Klersy, C., Sampietro, G., Ardizzone, S., Fociani, P., Fiocca, R., Latella, G., Sessa, F., D'Errico, A., Malvi, D., Mescoli, C., Rugge, M., Nesi, G., Ferrero, S., Furlan, D., Poggioli, G., Rizzello, F., Macciomei, M. C., Santini, D., Volta, U., De Giorgio, R., Caio, G., Calabro, A., Ciacci, C., D'Armiento, M., Rizzo, A., Solina, G., Martino, M., Tonelli, F., Villanacci, V., Cannizzaro, R., Canzonieri, V., Florena, A. M., Biancone, L., Monteleone, G., Caronna, R., Ciardi, A., Elli, L., Caprioli, F., Vecchi, M., D'Inca, R., Zingone, F., D'Odorico, A., Lenti, M. V., Oreggia, B., Bonetti, L. R., Astegiano, M., Biletta, E., Cantoro, L., Giannone, A. G., Orlandi, A., Papi, C., Perfetti, V., Quaquarini, E., Sandri, G., Silano, M., Usai, P., Barresi, V., Ciccocioppo, R., Luinetti, O., Pedrazzoli, P., Pietrabissa, A., Viglio, A., Paulli, M., Corazza, G. R., Solcia, E., Vanoli, A., and Di Sabatino, A.

Published
2020

3. Programmed Cell Death Ligand-1 (PD-L1) Expression is Coupled with Microsatellite Instability in Non-Familial Small Bowel Carcinomas Associated or not with Coeliac Disease or Crohn's Disease: Results from the Small Bowel Cancer Italian Consortium

Author

Vanoli, A., Giuffrida, P., Martino, M., Persichella, A., Viglio, A., Furlan, D., Klersy, C., Grillo, F., Fiocca, R., Mescoli, C., Rugge, M., Nesi, G., Fociani, P., Sampietro, G., Ardizzone, S., Luinetti, O., Calabro, A., Tonelli, F., Volta, U., Santini, D., Giacomo Caio, Elli, L., Ferrero, S., Latella, G., Ciardi, A., Caronna, R., Solina, G., Rizzo, A. G., Ciacci, C., D Armiento, F. P., Salemme, M., Villanacci, V., Cannizzaro, R., Canzonieri, V., Bonetti, L. Reggiani, Biancone, L., Monteleone, G., Orlandi, A., Santeusanio, G., Macciomei, M., D Inca, R., Perfetti, V., Sandri, G., Silano, M., Florena, A., Giannone, A., Papi, C., Coppola, L., Usai, P., Maccioni, A., Astegiano, M., Migliora, P., Sessa, F., Solcia, E., Corazza, G. R., Paulli, M., and Di Sabatino, A.

Subjects
NO
Published
2018

5. Small bowel carcinomas in celiac or Crohn's disease: Distinctive histophenotypic, molecular and histogenetic patterns

Author

Vanoli, A., Di Sabatino, A., Martino, M., Klersy, C., Grillo, F., Mescoli, C., Nesi, G., Volta, U., Fornino, D., Luinetti, O., Fociani, P., Villanacci, V., D'Armiento, F. P., Cannizzaro, R., Latella, G., Ciacci, C., Biancone, L., Paulli, M., Sessa, F., Rugge, M., Fiocca, R., Corazza, G. R., Solcia, E., Ardizzone, S., Astegiano, M., Caio, G., Calabro, A., Canzonieri, V., Cerutti, R., Ciardi, A., Coppola, L., D'Inca, R., Elli, L., Ferrero, S., Florena, A. M., Furlan, D., Giannone, A. G., Giuffrida, P., Macciomei, M. C., Maccioni, A., Monteleone, G., Migliora, P., Orlandi, A., Papi, C., Perfetti, V., Bonetti, L. R., Rizzo, A., Salemme, M., Sandri, G., Sampietro, G., Santeusanio, G., Santini, D., Silano, M., Solina, G., Tonelli, F., Trapani, D., Usai, P., Vanoli, Alessandro, Di Sabatino, Antonio, Martino, Michele, Klersy, Catherine, Grillo, Federica, Mescoli, Claudia, Nesi, Gabriella, Volta, Umberto, Fornino, Daniele, Luinetti, Ombretta, Fociani, Paolo, Villanacci, Vincenzo, D'Armiento, Francesco P., Cannizzaro, Renato, Latella, Giovanni, Ciacci, Carolina, Biancone, Livia, Paulli, Marco, Sessa, Fausto, Rugge, Massimo, Fiocca, Roberto, Corazza, Gino R., Solcia, Enrico, D'Armiento, Francesco P, and Corazza, Gino R

Subjects
0301 basic medicine, Adult, Male, medicine.medical_specialty, Pathology, small bowel carcinoma, celiac disease, immunology, gastrointestinal cancer, Kaplan-Meier Estimate, Histogenesis, Biology, Small, Gastroenterology, Pathology and Forensic Medicine, NO, Surgical pathology, immunology, inflammatory bowel disease, 03 medical and health sciences, small bowel carcinoma, 0302 clinical medicine, Crohn Disease, Internal medicine, Intestine, Small, Intestinal Neoplasms, medicine, Carcinoma, Humans, 2734 small bowel carcinoma, coeliac disease, Crohn's disease, Proportional Hazards Models, Retrospective Studies, Crohn's disease, Settore MED/12 - Gastroenterologia, Celiac Disease, Female, Middle Aged, Microsatellite instability, Anatomical pathology, medicine.disease, digestive system diseases, Intestine, 030104 developmental biology, Dysplasia, 030220 oncology & carcinogenesis, Hematopathology, celiac disease
Abstract

Non-familial small bowel carcinomas are relatively rare and have a poor prognosis. Two small bowel carcinoma subsets may arise in distinct immune-inflammatory diseases (celiac disease and Crohn's disease) and have been recently suggested to differ in prognosis, celiac disease-associated carcinoma cases showing a better outcome, possibly due to their higher DNA microsatellite instability and tumor-infiltrating T lymphocytes. In this study, we investigated the histological structure (glandular vs diffuse/poorly cohesive, mixed or solid), cell phenotype (intestinal vs gastric/pancreatobiliary duct type) and Wnt signaling activation (beta-catenin and/or SOX-9 nuclear expression) in a series of 26 celiac disease-associated small bowel carcinoma, 25 Crohn's disease-associated small bowel carcinoma and 25 sporadic small bowel carcinoma cases, searching for new prognostic parameters. In addition, non-tumor mucosa of celiac and Crohn's disease patients was investigated for epithelial precursor changes (hyperplastic, metaplastic or dysplastic) to help clarify carcinoma histogenesis. When compared with non-glandular structure and non-intestinal phenotype, both glandular structure and intestinal phenotype were associated with a more favorable outcome at univariable or stage-and microsatellite instability/tumor-infiltrating lymphocyte-inclusive multivariable analysis. The prognostic power of histological structure was independent of the clinical groups while the non-intestinal phenotype, associated with poor outcome, was dominant among Crohn's disease-associated carcinoma. Both nuclear beta-catenin and SOX-9 were preferably expressed among celiac disease-associated carcinomas; however, they were devoid, per se, of prognostic value. We obtained findings supporting an origin of celiac disease-associated carcinoma in SOX-9-positive immature hyperplastic crypts, partly through flat beta-catenin-positive dysplasia, and of Crohn's disease-associated carcinoma in a metaplastic (gastric and/or pancreatobiliary-type) mucosa, often through dysplastic polypoid growths of metaplastic phenotype. In conclusion, despite their common origin in a chronically inflamed mucosa, celiac disease-associated and Crohn's disease-associated small bowel carcinomas differ substantially in histological structure, phenotype, microsatellite instability/tumor-infiltrating lymphocyte status, Wnt pathway activation, mucosal precursor lesions and prognosis.

Published
2017

6. Editorial

Author

Nesi, G.

Subjects
Seconda Conferenza italo-brasiliana sul diritto
Published
2017

7. Crohn’s disease-associated small bowel carcinomas show distinctive histology and phenotype in comparison to sporadic cases: an italian multicentre study

Author

Vanoli, A., Grillo, F., Mescoli, C., Nesi, G., Giuffrida, P., Papi, C., Luinetti, O., Sampietro, G., Latella, Giovanni, Fociani, P., Tonelli, F., Cannizzaro, R., Coppola, L., D’Incà, R., Monteleone, G., Biancone, L., Solina, G., Villanacci, V., Martino, M., Orlandi, A., Rizzo, A., Salemme, M., Astegiano, M., Migliora, P., Rugge, M., Fiocca, R., Corazza, G. R., Solcia, E., and Di Sabatino, A.

Published
2016

10. Crohn’s disease-associated small bowel carcinomas show distinctive histologic and phenotypic features: an Italian multicentric study

Author

Di Sabatino, A. Vanoli, Grillo, Francesco, Mescoli, C., Nesi, G., Giuffrida, P., Papi, C., Luinetti, O., Sampietro, G., Latella, Giovanni, Fociani, P., Tonelli, F., Cannizzaro, R., Coppola, L., D’Incà, R., Monteleone, G., Biancone, L., Solina, G., Villanacci, V., Martino, M., Orlandi, A., Rizzo, A., Salemme, M., Astegiano, M., Migliora, P., Rugge, M., Fiocca, R., and Corazza, G. R.

Published
2016

12. Analisi delle varianti rare del carcinoma a cellule uroteliali della vescica nei Pazienti sottoposti a cistectomia radicale: impatto sulla prognosi

Author

Cai, T, Tiscione, D, Pomara, G, Verze, P, Racioppi, M, Nesi, G, Brausi, M, Gacci, M, Gontero, P, Francesca, F, Campodonico, F, Simonato, A, Di Stasi, S, Colombo, R, Carmignani, C, Malossini, G, Maffezzini, M, Altieri, V, Carini, M, Terrone, C, Selli, C, Bassi, P, Mirone, V, Bartoletti, R., SERRETTA, Vincenzo, Cai, T, Tiscione, D, Pomara, G, Verze, P, Racioppi, M, Nesi, G, Brausi, M, Gacci, M, Gontero, P, Francesca, F, Campodonico, F, Simonato, A, Di Stasi, S, Colombo, R, Serretta, V, Carmignani, C, Malossini, G, Maffezzini, M, Altieri, V, Carini, M, Terrone, C, Selli, C, Bassi, P, Mirone, V, and Bartoletti, R

Subjects
Tumore vescicale, cistectomia, istologia, Settore MED/24 - Urologia
Published
2013

16. FATTORI PREDITTIVI DI PATOLOGIA EXTRACAPSULARE IN PAZIENTI AFFETTI DA ETP PROSTATA IN STADIO CLINICO INFERIORE O UGUALE A CT2, CON GLEASON SCORE BIOPTICO INFERIORE O UGUALE A 3+3 E PSA PREOPERATORIO INFERIORE O UGUALE A 10

Author

Gacci M, Lapini A, SALONIA, ANDREA, Mearini L, Nesi G, Palli D, MONTORSI, FRANCESCO, Rigatti P, Porena M, Carini M., BRIGANTI , ALBERTO, Gacci, M, Lapini, A, Salonia, Andrea, Mearini, L, Nesi, G, Palli, D, Briganti, Alberto, Montorsi, Francesco, Rigatti, P, Porena, M, and Carini, M.

Published
2006

19. Sclerosing variant of PEComa: report of a case and review of the literature

Author

Santi R, ALESSANDRO FRANCHI, Villari D, Paglierani M, Pepi M, Danielli D, Nicita G, and Nesi G

Subjects
Sclerosis, Perivascular Epithelioid Cell Neoplasms, Sclerosing PEComa, 6 - Ciencias aplicadas::61 - Medicina::611 - Anatomía [CDU], Aged, Female, Humans, Retroperitoneal Neoplasms, Retro-peritoneal tumours
Abstract

Tumours of perivascular epithelioid cells (PEComas) are a heterogeneous group of uncommon mesenchymal neoplasms which exhibit a peculiar immunohistochemical co-expression of muscle and melanocytic markers. PEComas occur at various visceral and soft tissue sites, generally with a benign clinical course. Nevertheless, there has been evidence of cases having an unfavourable outcome, thus prompting investigation of pathological criteria for malignancy. A sclerosing variant of PEComa, more frequently encountered in the retroperitoneum of middle-aged women, has been reported. Prognosis has generally been regarded as favourable and complete surgical excision appears to be adequate treatment. To the best of our knowledge, only two cases of sclerosing PEComa displayed high-grade malignant morphology and were associated with adverse outcome. An additional case of retroperitoneal sclerosing PEComa with a two-year follow-up and indolent behaviour is herein described. Light and electron microscopy were performed, along with immunohistochemical analysis. Further studies are needed to clarify the histogenesis and to predict the biological behaviour of this uncommon entity.

Published
2012

25. Re: Predicting biochemical recurrence-free survival for patients with positive pelvic lymph nodes at radical prostatectomy: C. Von Bodman, G. Godoy, D. C. Chade, A. Cronin, L. J. Tafe, S. W. Fine, V. Laudone, P. T. Scardino and J. A. Eastham J Urol 2010; 184: 143-148

Author

Cai, T, Nesi, G, Malossini, G, and Bartoletti, Riccardo

Subjects
Male, Prostatectomy, Predictive Value of Tests, Lymphatic Metastasis, Disease-Free Survival, Humans, Prostate-Specific Antigen, Prostatic Neoplasms
Published
2011

34. CagA+ Helicobacter pylori infection and gastric cancer risk in the EPIC-EURGAST study

Author

Palli, D. Masala, G. Del Giudice, G. Plebani, M. Basso, D. Berti, D. Numans, M.E. Ceroti, M. Peeters, P.H.M. Bas Bueno De Mesquita, H. Buchner, F.L. Clavel-Chapelon, F. Boutron-Ruault, M.-C. Krogh, V. Saieva, C. Vineis, P. Panico, S. Tumino, R. Nyrén, O. Simán, H. Berglund, G. Hallmans, G. Sanchez, M.-J. Larrãnaga, N. Barricarte, A. Navarro, C. Quiros, J.R. Key, T. Allen, N. Bingham, S. Khaw, K.T. Boeing, H. Weikert, C. Linseisen, J. Nagel, G. Overvad, K. Thomsen, R.W. Tjonneland, A. Olsen, A. Trichoupoulou, A. Trichopoulos, D. Arvaniti, A. Pera, G. Kaaks, R. Jenab, M. Ferrari, P. Nesi, G. Carneiro, F. Riboli, E. Gonzalez, C.A.

Abstract

Helicobacter pylori (H. pylori), atrophic gastritis, dietary and lifestyle factors have been associated with gastric cancer (GC). These factors have been evaluated in a large case-control study nested in the European Prospective Investigation into Cancer and Nutrition carried out in 9 countries, including the Mediterranean area. Participants, enrolled in 1992-1998, provided life-style and dietary information and a blood sample (360,000; mean follow-up: 6.1 years). For 233 GC cases diagnosed after enrolment and their 910 controls individually-matched by center, gender, age and blood donation date H. pylori antibodies (antilysate and antiCagA) and plasma Pepsinogen A (PGA) were measured by ELISA methods. Severe chronic atrophic gastritis (SCAG) was defined as PGA circulating levels

Published
2007

37. SDH mutations in patients affected by paraganglioma syndromes

Author

Mannelli, M, Simi, L, Ercolino, T, Gagliano, Ms, Becherini, L, Vinci, S, Sestini, R, Gensini, F, Pinzani, P, Mascalchi, M, Guerrini, L, Pratesi, C, Nesi, G, Torti, F, Cipollini, F, Bernini, Giampaolo, and Genuardi, M.

Published
2006

41. Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC)

Author

González, C.A. Jakszyn, P. Pera, G. Agudo, A. Bingham, S. Palli, D. Ferrari, P. Boeing, H. del Giudice, G. Plebani, M. Carneiro, F. Nesi, G. Berrino, F. Sacerdote, C. Tumino, R. Panico, S. Berglund, G. Simán, H. Nyrén, O. Hallmans, G. Martinez, C. Dorronsoro, M. Barricarte, A. Navarro, C. Quirós, J.R. Allen, N. Key, T.J. Day, N.E. Linseisen, J. Nagel, G. Bergmann, M.M. Overvad, K. Jensen, M.K. Tjonneland, A. Olsen, A. Bueno-de-Mesquita, H.B. Ocke, M. Peeters, P.H.M. Numans, M.E. Clavel-Chapelon, F. Boutron-Ruault, M.-C. Trichopoulou, A. Psaltopoulou, T. Roukos, D. Lund, E. Hemon, B. Kaaks, R. Norat, T. Riboli, E.

Abstract

Background: Dietary factors are thought to have an important role in gastric and esophageal carcinogenesis, but evidence from cohort studies for such a role is lacking. We examined the risks of gastric cancer and esophageal adenocarcinoma associated with meat consumption within the European Prospective Investigation Into Cancer and Nutrition (EPIC) cohort. Methods: A total of 521 457 men and women aged 35=70 years in 1 0 European countries participated in the EPIC cohort. Dietary and lifestyle information was collected at recruitment. Cox proportional hazard models were used to examine associations between meat intake and risks of cardia and gastric noncardia cancers and esophageal adenocarcinoma. Data from a calibration substudy were used to correct hazard ratios (HRs) and 95% confidence intervals (CIs) for diet measurement errors. In a nested case-control study, we examined interactions between Helicobacter pylori infection status (i.e., plasma H. pylori antibodies) and meat intakes. All statistical tests were two-sided. Results: During a mean follow-up of 6.5 years, 330 gastric adenocarcinoma and 65 esophageal adenocarcinomas were diagnosed. Gastric noncardia cancer risk was statistically significantly associated with intakes of total meat (calibrated HR per 100-g/day increase = 3.52; 95% CI 1.96 to 6.34), red meat (calibrated HR per 50-g/day increase = 1.73; 95% CI = 1.03 to 2.88), and processed meat (calibrated HR per 50-g/day increase = 2.45; 95% CI = 1.43 to 4.21). The association between the risk of gastric noncardia cancer and total meat intake was especially large in H. pylori-infected subjects (odds ratio per 100-g/day increase = 5.32; 95% CI = 2.10 to 13.4). Intakes of total, red, or processed meat were not associated with the risk of gastric cardia cancer. A positive but non-statistically significant association was observed between esophageal adenocarcinoma cancer risk and total and processed meat intake in the calibrated model. In this study population, the absolute risk of development of gastric adenocarcinoma within 10 years for a study subject aged 60 years was 0.26% for the lowest quartile of total meat intake and 0.33% for the highest quartile of total meat intake. Conclusion: Total, red, and processed meat intakes were associated with an increased risk of gastric noncardia cancer, especially in H. pylori antibody-positive subjects, but not with cardia gastric cancer. © 2006 Oxford University Press.

Published
2006

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