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1. The anaesthetized rabbit with acute atrioventricular block provides a new model for detecting drug‐induced Torsade de Pointes

Author

Hagiwara, Mihoko, Shibuta, Seiji, Takada, Kazuhiro, Kambayashi, Ryuichi, Nakajo, Misako, Aimoto, Megumi, Nagasawa, Yoshinobu, and Takahara, Akira

Subjects
Male, Disease Models, Animal, Torsades de Pointes, Animals, Anesthesia, Rabbits, Atrioventricular Block, Research Papers, Anti-Arrhythmia Agents, Anti-Bacterial Agents, Antipsychotic Agents
Abstract

Several rabbit proarrhythmia models have been developed using genetic or pharmacological methods to suppress the slow component of delayed rectifier KBradycardia was induced in isoflurane-anaesthetized rabbits by inducing AVB with catheter ablation, and the ventricle was electrically driven at 60 beats minIn our model, TdP arrhythmias appeared with high reproducibility after i.v. dofetilide (10-100 μg·kgThese results suggest that our model of the unremodelled and bradycardic heart of the anaesthetized rabbit is a useful test system for the detection of drug-induced TdP arrhythmias.

Published
2017

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