1. Does omeprazole improve asthma-control in poorly-controlled asthmatic children with gastro-esophageal reflux
- Author
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Youcef Laid, Keltoum Nafissa Benhalla, Abdelghani Yagoubi, Fadila Benhassine, and Leila Smati
- Subjects
Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Adolescent ,genetic structures ,Disease ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Asthma control ,Internal medicine ,Prevalence ,medicine ,Humans ,Immunology and Allergy ,Prospective Studies ,Child ,Omeprazole ,Asthma ,business.industry ,digestive, oral, and skin physiology ,Reflux ,medicine.disease ,digestive system diseases ,030228 respiratory system ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Gastroesophageal Reflux ,GERD ,business ,medicine.drug - Abstract
The role of gastro-esophageal reflux disease (GERD) in poorly controlled asthma is often mentioned, but published studies have presented discordant results. Our main objective was to assess the effectiveness of GERD treatment in controlling asthma in children.We conducted a prospective study including poorly controlled asthmatic children aged 4 to 16 years. We checked the presence of acid reflux using pH monitoring. Patients with GERD were randomized into two groups; one received omeprazole for 6 months and the control group was not treated. The outcome was the score of the children asthma control test at the end of 6 months. The acid suppression was checked at the end of treatment with pH monitoring. After treatment, children with persistent acid reflux received high PPI doses and therefore were reevaluated 6 months later.We included 102 children with poorly controlled asthma among which 59 (57.8%) had acid reflux. Gastroesophageal reflux (GER) was significantly more common in boys (This study confirmed the high prevalence of GER in poorly controlled asthmatic children and showed the possible benefit of an efficient GER treatment in improving asthma control.
- Published
- 2021