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Electroporation-based cancer treatment techniques are currently after active investigations in the field of drug delivery, optimization of electrical parameters and elucidation of the exact mechanisms at a molecular level. The present study is designed to investigate the exact in vivo redistribution and persistence of nanoparticles in the tumor tissue f colon-cancer grafted mice after electroporation with two different kinds of electrodes.The aim of the study is to avoid artifacts during electroporation due to accumulation of nanoparticles in the surrounding non-cancer tissues. The isolated electrodes are appropriate for the treatment of 3-dimensional tumors and have a large potential in this field. Keywords: Electroassisted drug delivery, in vivo imaging, Cancer, Nanoparticles, Quantum dots.

The present study was designed to investigate whether electroporation can facilitate the delivery of drugs inside tumors, using quantum dot (QD)-loaded polymersomes as a model. The main goal was to increase the local concentration of anticancer drugs avoiding side-effects. The experiments were performed on colon-cancer grafted mice (Balb/c) using Maestro EX Imaging System. Electroporation facilitated the delivery of nanoparticles inside the tumor. A significant difference in the fluorescence intensity between electroporated and non-electroporated mice was observed in cancer area even 24 hours after treatment with nanoparticles. The data suggest that electro-assisted delivery of size-controlled long-circulating polymersomes in cancer is a promising therapeutic strategy, especially for treatment of solid tumors.

Electrochemotherapy is one fast, easy, effective and safe method for treatment of patients with clinical and cytological diagnosis of skin tumors as Carcinoma basocellulare, Carcinoma spinocellulare, Kaposi sarkoma and Mycosis fungoides in stage I (T1N0M0). Therapy is based on the temporary formation of pores on the surface of the cell membrane, resulting from the application of electric field with appropriate intensity and duration trough which the cytostatic drug as bleomycin is introduced into the tumor cells. This work presents data on the last version of electroporator and the treated patients by the method electrochemotherapy recently.

The subject of this paper is the design and implementation of the philosophy of total quality management (TQM) in some segments of Macedonian Railways - Transport which produce services of public interest in the Republic of Macedonia. By analyzing the company's business processes and optimizing them to achieve consistently exceeding the growing expectations of service users. Special activities are analyzed in control department of revenue or in business process of data input from the tickets where mistakes are detected on a monthly basis. To this aim, is used the TQM methodology which is based on exploiting the knowledge of all employees and operating teams in the continuous improvement of business processes, including the methods and techniques for faultless operation. The results of this study showed that the application of total quality management in Macedonian Railways - Transport not only lead to improvement of service quality, but also increased productivity and cost optimization of quality. In the future, the implementation of this methodology in the company will not only enable satisfaction of service users, but also satisfaction to suppliers, employees and the community. Keywords: Improvement of quality control charts, Pareto analysis, Ishikawa diagram, Total quality management (TQM).

Background: There are several mobile health (mHealth) apps in mobile app stores. These apps enter the business-to-customer market with limited controls. Both, apps that users use autonomously and those designed to be recommended by practitioners require an end-user validation to minimize the risk of using apps that are ineffective or harmful. Prior studies have reviewed the most relevant aspects in a tool designed for assessing mHealth app quality, and different options have been developed for this purpose. However, the psychometric properties of the mHealth quality measurement tools, that is, the validity and reliability of the tools for their purpose, also need to be studied. The Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) initiative has developed tools for selecting the most suitable measurement instrument for health outcomes, and one of the main fields of study was their psychometric properties. Objective: This study aims to address and psychometrically analyze, following the COSMIN guideline, the quality of the tools that are used to measure the quality of mHealth apps. Methods: From February 1, 2019, to December 31, 2019, 2 reviewers searched PubMed and Embase databases, identifying mHealth app quality measurement tools and all the validation studies associated with each of them. For inclusion, the studies had to be meant to validate a tool designed to assess mHealth apps. Studies that used these tools for the assessment of mHealth apps but did not include any psychometric validation were excluded. The measurement tools were analyzed according to the 10 psychometric properties described in the COSMIN guideline. The dimensions and items analyzed in each tool were also analyzed. Results: The initial search showed 3372 articles. Only 10 finally met the inclusion criteria and were chosen for analysis in this review, analyzing 8 measurement tools. Of these tools, 4 validated ≥5 psychometric properties defined in the COSMIN guideline. Although some of the tools only measure the usability dimension, other tools provide information such as engagement, esthetics, or functionality. Furthermore, 2 measurement tools, Mobile App Rating Scale and mHealth Apps Usability Questionnaire, have a user version, as well as a professional version. Conclusions: The Health Information Technology Usability Evaluation Scale and the Measurement Scales for Perceived Usefulness and Perceived Ease of Use were the most validated tools, but they were very focused on usability. The Mobile App Rating Scale showed a moderate number of validated psychometric properties, measures a significant number of quality dimensions, and has been validated in a large number of mHealth apps, and its use is widespread. It is suggested that the continuation of the validation of this tool in other psychometric properties could provide an appropriate option for evaluating the quality of mHealth apps. Yes

Digital health interventions may improve different behaviours. However, the rapid proliferation of technological solutions often does not allow for a correct assessment of the quality of the tools. This study aims to review and assess the quality of the available mobile applications (apps) related to interventions for low back pain. Two reviewers search the official stores of Android (Play Store) and iOS (App Store) for localisation in Spain and the United Kingdom, in September 2019, searching for apps related to interventions for low back pain. Seventeen apps finally are included. The quality of the apps is measured using the Mobile App Rating Scale (MARS). The scores of each section and the final score of the apps are retrieved and the mean and standard deviation obtained. The average quality ranges between 2.83 and 4.57 (mean 3.82) on a scale from 1 (inadequate) to 5 (excellent). The best scores are found in functionality (4.7), followed by aesthetic content (mean 4.1). Information (2.93) and engagement (3.58) are the worst rated items. Apps generally have good overall quality, especially in terms of functionality and aesthetics. Engagement and information should be improved in most of the apps. Moreover, scientific evidence is necessary to support the use of applied health tools.