1. Initial assessment of the economic burden of major parasitic helminth infections to the ruminant livestock industry in Europe
- Author
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Charlier, J., Rinaldi, L., Musella, V., Ploeger, H. W., Chartier, C., Vineer, H. Rose, Hinney, B., von Samson-Himmelstjerna, G., Băcescu, B., Mickiewicz, M., Mateus, T. L., Martinez-Valladares, M., Quealy, S., Azaizeh, H., Sekovska, B., Akkari, H., Petkevicius, S., Hektoen, L., Höglund, J., Morgan, E. R., Bartley, D. J., Claerebout, E., Klinische infectiologie en microb. lab., dI&I I&I-4, Martínez Valladares, María [0000-0002-3723-1895], Kreavet, Department of Veterinary Medicine and Animal Productions, 'Federico II' University of Naples Medical School, Università degli Studi 'Magna Graecia' di Catanzaro [Catanzaro, Italie] (UMG), Utrecht University [Utrecht], Biologie, Epidémiologie et analyse de risque en Santé Animale (BIOEPAR), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Liverpool, University of Veterinary Medicine [Vienna] (Vetmeduni), Institute for Parasitology and Tropical Veterinary Medicine, Freie Universität Berlin, Spiru Haret University, Warsaw University of Life Sciences (SGGW), Polytechnic Institute of Viana do Castelo, Instituto de Saúde Pública da Universidade do Porto [Porto, Portugal] (ISPUP), Universidade do Porto, Departamento de Sanidad Animal, Instituto de Ganadería de Montaña, Consejo Superior de Investigaciones Científicas, VirtualVet, University of Haifa [Haifa], Ss. Cyril and Methodius University in Skopje, École Nationale de Médecine Vétérinaire de Sidi Thabet, Ministère de l’Agriculture, des Ressources Hydrauliques et de la Pêche Maritime [Tunisie], Lithuanian University of Health Sciences [Kaunas, Lithuania], Norwegian University of Life Sciences (NMBU), Swedish University of Agricultural Sciences (SLU), Queen's University [Belfast] (QUB), Moredun Research Institute [Penicuik, UK] (MRI), Universiteit Gent = Ghent University [Belgium] (UGENT), European Cooperation in Science and Technology, Livestock Helminth Research Alliance, Biotechnology and Biological Sciences Research Council (UK), Ministerio de Economía y Competitividad (España), Martínez Valladares, María, Klinische infectiologie en microb. lab., dI&I I&I-4, Charlier, J., Rinaldi, L., Musella, V., Ploeger, H. W., Chartier, C., Vineer, H. R., Hinney, B., von Samson-Himmelstjerna, G., Bacescu, B., Mickiewicz, M., Mateus, T. L., Martinez-Valladares, M., Quealy, S., Azaizeh, H., Sekovska, B., Akkari, H., Petkevicius, S., Hektoen, L., Hoglund, J., Morgan, E. R., Bartley, D. J., Claerebout, E., COMBAR, Charlier, J, Rinaldi, L, Musella, V, Ploeger, Hw, Chartier, C, Rose Vineer, H, Hinney, B, von Samson-Himmelstjerna, G, Băcescu, B, Mickiewicz, M, Mateus, Tl, Martinez-Valladares, M, Quealy, S, Azaizeh, H, Sekovska, B, Akkari, H, Petkevicius, S, Hektoen, L, Höglund, J, Morgan, Er, Bartley, Dj, Claerebout, E, and Instituto de Saúde Pública da Universidade do Porto
- Subjects
[SDV]Life Sciences [q-bio] ,Resistance ,Direct cost ,Cattle Diseases ,0403 veterinary science ,Indirect costs ,Cost of Illness ,Food Animals ,Economic cost ,Direct costs ,Anthelmintic ,Economic impact analysis ,health care economics and organizations ,2. Zero hunger ,Anthelmintics ,0303 health sciences ,education.field_of_study ,Goats ,Ostertagia ,04 agricultural and veterinary sciences ,3. Good health ,Europe ,Dictyocaulus ,Goat ,Dictyocaulu ,Fascioliasis ,040301 veterinary sciences ,Population ,Sheep Diseases ,Biology ,03 medical and health sciences ,Environmental health ,parasitic diseases ,Dictyocaulus Infections ,Animals ,education ,Ostertagia Fasciola ,Sheep, Domestic ,Dairy cattle ,030304 developmental biology ,Goat Diseases ,Sheep ,Food security ,Fasciola hepatica ,biology.organism_classification ,Cattle ,Economic costs ,Fasciola ,Animal Science and Zoology ,Lungworm - Abstract
12 páginas, 4 figuras, 4 tablas., We report a European wide assessment of the economic burden of gastrointestinal nematodes, Fasciola hepatica (common liver fluke) and Dictyocaulus viviparus (bovine lungworm) infections to the ruminant livestock industry. The economic impact of these parasitic helminth infections was estimated by a deterministic spreadsheet model as a function of the proportion of the ruminant population exposed to grazing, the infection frequency and intensity, the effect of the infection on animal productivity and mortality and anthelmintic treatment costs. In addition, we estimated the costs of anthelmintic resistant nematode infections and collected information on public research budgets addressing helminth infections in ruminant livestock. The epidemiologic and economic input data were collected from international databases and via expert opinion of the Working Group members of the European Co-operation in Science and Technology (COST) action COMbatting Anthelmintic Resistance in ruminants (COMBAR). In order to reflect the effects of uncertainty in the input data, low and high cost estimates were obtained by varying uncertain input data arbitrarily in both directions by 20 %. The combined annual cost [low estimate-high estimate] of the three helminth infections in 18 participating countries was estimated at € 1.8 billion [€ 1.0–2.7 billion]. Eighty-one percent of this cost was due to lost production and 19 % was attributed to treatment costs. The cost of gastrointestinal nematode infections with resistance against macrocyclic lactones was estimated to be € 38 million [€ 11–87 million] annually. The annual estimated costs of helminth infections per sector were € 941 million [€ 488 – 1442 million] in dairy cattle, € 423 million [€ 205–663 million] in beef cattle, € 151million [€ 90–213 million] in dairy sheep, € 206 million [€ 132–248 million] in meat sheep and € 86 million [€ 67–107 million] in dairy goats. Important data gaps were present in all phases of the calculations which lead to large uncertainties around the estimates. Accessibility of more granular animal population datasets at EU level, deeper knowledge of the effects of infection on production, levels of infection and livestock grazing exposure across Europe would make the largest contribution to improved burden assessments. The known current public investment in research on helminth control was 0.15 % of the estimated annual costs for the considered parasitic diseases. Our data suggest that the costs of enzootic helminth infections which usually occur at high prevalence annually in ruminants, are similar or higher than reported costs of epizootic diseases. Our data can support decision making in research and policy to mitigate the negative impacts of helminth infections and anthelmintic resistance in Europe, and provide a baseline against which to measure future changes., This article is based upon work from COST Action COMBAR CA16230, supported by COST (European Cooperation in Science and Technology) and from the Livestock helminth Research Alliance (LiHRA). HRV and ERM are supported by the BBSRC BUG (Building on the Genome) sLoLa project (grant ref: BB/M003949/1, and BB/ R010250/1). HRV is also supported by the University of Liverpool’s Institute of Infection and Global Health. MMV was funded by the Spanish “Ramón y Cajal” Programme, Ministry of Economy and Competitiveness (Ministerio de Economía y Competitividad; RYC-2015-18368).
- Published
- 2020