Author: "Murru A" / Database: OpenAIRE - Searchworks@Jio Institute Digital Library Search Results

1,483 results on '"Murru A"'

1. Efficacy of front-line ibrutinib versus fludarabine, cyclophosphamide and rituximab (FCR) in patients with CLL. A retrospective multicenter 'real-world' study

Author: Levi, Shai, Bronstein, Yotam, Goldschmidt, Neta, Morabito, Fortunato, Ziv-Baran, Tomer, Del Poeta, Giovanni, Bairey, Osnat, Del Principe, Maria Ilaria, Fineman, Riva, Mauro, Francesca Romana, Gutwein, Odit, Reda, Gianluigi, Ruchlemer, Rosa, Sportoletti, Paolo, Laurenti, Luca, Shvidel, Lev, Coscia, Marta, Tadmor, Tamar, Varettoni, Marzia, Aviv, Ariel, Murru, Roberta, Braester, Andrei, Chiarenza, Annalisa, Visentin, Andrea, Pietrasanta, Daniela, Loseto, Giacomo, Zucchetto, Antonella, Bomben, Riccardo, Olivieri, Jacopo, Neri, Antonio, Rossi, Davide, Gaidano, Gianluca, Trentin, Livio, Foà, Robin, Cuneo, Antonio, Perry, Chava, Gattei, Valter, Gentile, Massimo, and Herishanu, Yair
Subjects: Settore MED/15
Published: 2023

2. Real time Gutenberg–Richter b-value estimation for an ongoing seismic sequence: an application to the 2022 marche offshore earthquake sequence (ML 5.7 central Italy)

Author: I Spassiani, M Taroni, M Murru, and G Falcone
Subjects: Geophysics, Geochemistry and Petrology
Abstract: SUMMARY We estimate the b-value parameter of the Gutenberg–Richter law for earthquake magnitudes in the early stage of the Costa Marchigiana (Italy) seismic sequence, starting on 2022 November 9, with an ML 5.7 event in the Adriatic sea. In particular, we estimate both the completeness magnitude Mc and the b-value within the first 4 and 7 d after the initial strong event in the sequence. Our work represents a practical example of b-value estimation in ‘true’ real time, that is, during the seismic sequence, and its possible interpretation in terms of short-term forecasting. We highlight some critical issues to consider both in estimating/intepreting the b-value, and in evaluating the real time estimation of Mc. These issues are mainly due to the fact that preliminary catalogues available in real time are quite different from the revised ones, which are usually delivered after a few months. The criticalities are linked to the raw data recorded at an early-stage, an unreliable evaluation of the Mc with statistical approaches, the Short Term Aftershock Incompleteness entailed after the initial strong event, and the magnitude binning. Our results show that real time estimation of the b-value can give insights into the evolution of an ongoing seismic sequence, when attention is paid to data quality and quantity.
Published: 2023

3. Controlling the Conformation of 2-Dimethylaminobiphenyls by Transient Intramolecular Hydrogen Bonding

Author: Daniele Del Giudice, Matteo Valentini, Carla Sappino, Emanuele Spatola, Aurora Murru, Gianfranco Ercolani, and Stefano Di Stefano
Subjects: Organic Chemistry, Settore CHIM/06
Published: 2023

4. Affective temperaments mediate aggressive dimensions in bipolar disorders: A cluster analysis from a large, cross-sectional, international study

Author: Giovanna Fico, Delfina Janiri, Marco Pinna, Maria Sagué-Vilavella, Anna Gimenez Palomo, Vincenzo Oliva, Michele De Prisco, Pablo Guzmán Cortez, Gerard Anmella, Xenia Gonda, Gabriele Sani, Leonardo Tondo, Eduard Vieta, and Andrea Murru
Subjects: Psychiatry and Mental health, Clinical Psychology
Abstract: Affective temperaments show potential for aggressive behavior (AB) preventive strategies in bipolar disorder (BD). We aim to define intra-diagnostic subgroups of patients with BD based on homogeneous behaviors related to AB. Subsequently, to assess whether affective temperament dimensions may contribute to the presence and severity of AB.Patients with BD were recruited. AB was evaluated through the modified overt aggression scale (MOAS); affective temperaments were assessed with the TEMPS-A. A cluster analysis was conducted based on TEMPS-A and MOAS scores. Stepwise backward logistic regression models were used to identify the predictive factors of cluster membership.799 patients with BD were enrolled. Three clusters were determined: non-aggressive (55.5 %), self-aggressive (18 %), and hetero-aggressive (26.5 %). Depressive, irritable, and anxious temperament scores significantly increased from the non-aggressive (lower) to the self-aggressive (intermediate) and the hetero-aggressive group (highest). A positive history of a suicide attempt (B = 5.131; OR = 169.2, 95 % CI 75.9; 377) and rapid cycling (B = -0.97; OR = 0.40, 95 % CI 0.17; 0.95) predicted self-aggressive cluster membership. Atypical antipsychotics (B = 1.19; OR = 3.28, 95 % CI 2.13; 5.06) or SNRI treatment (B = 1.09; OR = 3, 95 % CI 1.57; 5.71), psychotic symptoms (B = 0.73; OR = 2.09, 95 % CI 1.34; 3.26), and history of a suicide attempt (B = -1.56; OR = 0.20, 95 % CI 0.11; 0.38) predicted hetero-aggressive cluster membership.Recall bias might have affected the recollection of AB.Clinical factors orientate the prevention of different ABs in BD. Affective temperaments might play a role in preventing AB since patients with more pronounced affective temperaments might have an increased risk of showing AB, in particular hetero-AB.
Published: 2023

5. Psychotropic drug repurposing for COVID-19: A Systematic Review and Meta-Analysis

Author: Giovanna Fico, Ulker Isayeva, Michele De Prisco, Vincenzo Oliva, Brisa Solè, Laura Montejo, Iria Grande, Nestor Arbelo, Marta Gomez-Ramiro, Luis Pintor, Bernardo Carpiniello, Mirko Manchia, Eduard Vieta, and Andrea Murru
Subjects: Pharmacology, Psychiatry and Mental health, Neurology, Pharmacology (medical), Neurology (clinical), Biological Psychiatry
Abstract: Several psychotropic drugs, including antidepressants (AD), mood stabilizers, and antipsychotics (AP) have been suggested to have favorable effects in the treatment of COVID-19. The aim of this systematic review and meta-analysis was to collect evidence from studies concerning the scientific evidence for the repurposing of psychotropic drugs in COVID-19 treatment. Two independent authors searched PubMed-MEDLINE, Scopus, PsycINFO, and ClinicalTrials.gov databases, and reviewed the reference lists of articles for eligible articles published up to 13th December 2021. All computational, preclinical and clinical (observational and/or RCTs) studies on the effect of any psychotropic drug on Sars-CoV-2 or patients with COVID-19 were considered for inclusion. We conducted random effect meta-analyses on clinical studies reporting the effect of AD or AP on COVID-19 outcomes. 29 studies were included in the synthesis: 15 clinical, 9 preclinical, and 5 computational studies. 9 clinical studies could be included in the quantitative analyses. AD did not increase the risk of severe COVID-19 (RR= 1.71; CI 0.65-4.51) or mortality (RR=0.94; CI 0.81-1.09). Fluvoxamine was associated with a reduced risk of mortality for COVID-19 (OR=0.15; CI 0.02-0.95). AP increased the risk of severe COVID-19 (RR=3.66; CI 2.76-4.85) and mortality (OR=1.53; CI 1.15-2.03). Fluvoxamine might be a possible candidate for psychotropic drug repurposing in COVID-19 due to its anti-inflammatory and antiviral potential, while evidence on other AD is still controversial. Although AP are associated with worse COVID-19 outcomes, their use should be evaluated case to case and ongoing treatment with antipsychotics should be not discontinued in psychiatric patients.
Published: 2023

6. Thrombotic and Bleeding Complications in Patients with Chronic Lymphocytic Leukemia and Severe COVID-19: A Study of Eric, the European Research Initiative on CLL

Author: Darko Antic, Natasa Milic, Thomas Chatzikonstantinou, Lydia Scarfò, Vladimir Otasevic, Nina Rajovic, David Allsup, Alejandro Alonso Cabrero, Martin Andres, Monica Baile Gonzales, Antonella Capasso, Rosa Collado, Raul Cordoba, Carolina Cuéllar-García, Juan Gonzalo Correa, Lorenzo De Paoli, Maria Rosaria De Paolis, Giovanni Del Poeta, Maria Dimou, Michael Doubek, Maria Efstathopoulou, Shaimaa El-Ashwah, Alicia Enrico, Blanca Espinet, Lucia Farina, Angela Ferrari, Myriam Foglietta, Alberto Lopez-Garcia, José A. García-Marco, Rocío García-Serra, Massimo Gentile, Eva Gimeno, Maria Gomes da Silva, Odit Gutwein, Yervand K. Hakobyan, Yair Herishanu, José Ángel Hernández-Rivas, Tobias Herold, Gilad Itchaki, Ozren Jaksic, Ann Janssens, Olga B. Kalashnikova, Elżbieta Kalicińska, Arnon P. Kater, Sabina Kersting, Maya Koren-Michowitz, Jorge Labrador, Deepesh Lad, Luca Laurenti, Alberto Fresa, Mark-David Levin, Carlota Mayor Bastida, Lara Malerba, Roberto Marasca, Monia Marchetti, Juan Marquet, Biljana Mihaljevic, Ivana Milosevic, Fatima Mirás, Marta Morawska, Marina Motta, Talha Munir, Roberta Murru, Raquel Nunes, Jacopo Olivieri, Miguel Arturo Pavlovsky, Inga Piskunova, Viola Maria Popov, Francesca Maria Quaglia, Giulia Quaresmini, Gianluigi Reda, Gian Matteo Rigolin, Amit Shrestha, Martin Šimkovič, Svetlana Smirnova, Martin Špaček, Paolo Sportoletti, Oana Stanca, Niki Stavroyianni, Doreen Te Raa, Kristina Tomic, Sanne Tonino, Livio Trentin, Ellen Van Der Spek, Michel van Gelder, Marzia Varettoni, Andrea Visentin, Candida Vitale, Vojin Vukovic, Ewa Wasik-Szczepanek, Tomasz Wróbel, Lucrecia Yáñez San Segundo, Mohamed Yassin, Marta Coscia, Alessandro Rambaldi, Emili Montserrat, Robin Foà, Antonio Cuneo, Marc Carrier, Paolo Ghia, Kostas Stamatopoulos, [Antic D] Lymphoma Center, Clinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia. Faculty of Medicine, University of Belgrade, Belgrade, Serbia. [Milic N, Rajovic N] Department of Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Belgrade, Serbia. [Chatzikonstantinou T] Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece. Institute of Applied Biosciences, Centre for Research and Technology Hellas, Thessaloniki, Greece. [Scarfò L] Università Vita-Salute San Raffaele and IRCC Ospedale San Raffaele, Milan, Italy. [Otasevic V] Lymphoma Center, Clinic for Hematology, University Clinical Center of Serbia, Belgrade, Serbia. [Cuéllar-García C] Hematology Unit Hospital de Terrassa, Consorci Sanitari de Terrassa, Terrassa, Spain, Consorci Sanitari de Terrassa, Interne Geneeskunde, MUMC+: MA Hematologie (9), RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Experimental Immunology, Clinical Haematology, AII - Cancer immunology, Graduate School, CCA - Cancer Treatment and Quality of Life, and Universidad de Cantabria
Subjects: Cancer Research, Cardiovascular Diseases::Vascular Diseases::Embolism and Thrombosis::Thrombosis [DISEASES], Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Hematologic Agents::Anticoagulants [CHEMICALS AND DRUGS], Age, Anticoagulation therapy, Bleeding, CLL, COVID-19, D-dimer, LMWH, Thromboprophylaxis, Thrombosis, COVID-19 (Malaltia), Biochemistry, COVID-19 Testing, virosis::infecciones por virus ARN::infecciones por Nidovirales::infecciones por Coronaviridae::infecciones por Coronavirus [ENFERMEDADES], afecciones patológicas, signos y síntomas::procesos patológicos::hemorragia [ENFERMEDADES], Trombosi, Chronic, RISK, Leukemia, Low-Molecular-Weight, Pathological Conditions, Signs and Symptoms::Pathologic Processes::Hemorrhage [DISEASES], Virus Diseases::RNA Virus Infections::Nidovirales Infections::Coronaviridae Infections::Coronavirus Infections [DISEASES], Venous Thromboembolism, Hemorràgia, enfermedades cardiovasculares::enfermedades vasculares::embolia y trombosis::trombosis [ENFERMEDADES], Hematology, Lymphocytic, Oncology, Aged, Anticoagulants, Hemorrhage, Heparin, Low-Molecular-Weight, Humans, SARS-CoV-2, Leukemia, Lymphocytic, Chronic, B-Cell, Life Sciences & Biomedicine, Immunology, 610 Medicine & health, COVID-19/drug therapy, Molecular Biology, Science & Technology, Heparin, B-Cell, Cell Biology, acciones y usos químicos::acciones farmacológicas::usos terapéuticos::fármacos hematológicos::anticoagulantes [COMPUESTOS QUÍMICOS Y DROGAS], COVID-19 Drug Treatment, Settore MED/15 - MALATTIE DEL SANGUE, Anticoagulants (Medicina), 610 Medizin und Gesundheit
Abstract: Background Patients with chronic lymphocytic leukemia (CLL) may be more susceptible to COVID-19 related poor outcomes, including thrombosis and death, due to the advanced age, the presence of comorbidities, and the disease and treatment-related immune deficiency. The aim of this study was to assess the risk of thrombosis and bleeding in patients with CLL affected by severe COVID-19. Methods This is a retrospective multicenter study conducted by ERIC, the European Research Initiative on CLL, including patients from 79 centers across 22 countries. Data collection was conducted between April and May 2021. The COVID-19 diagnosis was confirmed by the real-time polymerase chain reaction (RT-PCR) assay for SARS-CoV-2 on nasal or pharyngeal swabs. Severe cases of COVID-19 were defined by hospitalization and the need of oxygen or admission into ICU. Development and type of thrombotic events, presence and severity of bleeding complications were reported during treatment for COVID-19. Bleeding events were classified using ISTH definition. STROBE recommendations were used in order to enhance reporting. Results A total of 793 patients from 79 centers were included in the study with 593 being hospitalized (74.8%). Among these, 511 were defined as having severe COVID: 162 were admitted to the ICU while 349 received oxygen supplementation outside the ICU. Most patients (90.5%) were receiving thromboprophylaxis. During COVID-19 treatment, 11.1% developed a thromboembolic event, while 5.0% experienced bleeding. Thrombosis developed in 21.6% of patients who were not receiving thromboprophylaxis, in contrast to 10.6% of patients who were on thromboprophylaxis. Bleeding episodes were more frequent in patients receiving intermediate/therapeutic versus prophylactic doses of low-molecular-weight heparin (LWMH) (8.1% vs. 3.8%, respectively) and in elderly. In multivariate analysis, peak D-dimer level and C-reactive protein to albumin ratio were poor prognostic factors for thrombosis occurrence (OR = 1.022, 95%CI 1.007‒1.038 and OR = 1.025, 95%CI 1.001‒1.051, respectively), while thromboprophylaxis use was protective (OR = 0.199, 95%CI 0.061‒0.645). Age and LMWH intermediate/therapeutic dose administration were prognostic factors in multivariate model for bleeding (OR = 1.062, 95%CI 1.017–1.109 and OR = 2.438, 95%CI 1.023–5.813, respectively). Conclusions Patients with CLL affected by severe COVID-19 are at a high risk of thrombosis if thromboprophylaxis is not used, but also at increased risk of bleeding under the LMWH intermediate/therapeutic dose administration.
Published: 2022

7. Differences in Clinical Course and Management of Sars-CoV2 Infection in Patients with Chronic Lymphocytic Leukemia between the Sequential Pandemic Phases: An Eric Study

Author: Andrea Visentin, Lydia Scarfò, Thomas Chatzikonstantinou, Anargyros Kapetanakis, Christos Demosthenous, Georgios Karakatsoulis, Martin Andres, Darko Antic, David Allsup, Mónica Baile, Dominique Bron, Antonella Capasso, Mark Catherwood, Rosa Collado, Raul Cordoba, Carolina Cuéllar-García, Julio Delgado, Maria Dimou, Michael Doubek, Lorenzo De Paoli, Maria Rosaria De Paolis, Giovanni Del Poeta, Maria Efstathopoulou, El-Ashwah Shimaa, Alicia Enrico, Lucia Farina, Angela Ferrari, Myriam Foglietta, Moritz Furstenau, Jose A. Garcia-Marco, Massimo Gentile, Eva Gimeno, Gomes da Silva Maria, Odit Gutwein, Yervand Hakobyan, Yair Herishanu, jose Angel Hernandez, Tobias Herold, Sunil Iyengar, Gilad Itchaki, Ozren Jaksic, Ann Janssens, Olga Kalashnikova, Elzbieta Kalicinska, Arnon P. Kater, Sabina Kersting, Jorge Labrador, Deepesh Lad, Luca Laurenti, Mark-David Levin, Enrico Lista, Lara Malerba, Roberto Marasca, Monia Marchetti, Juan Marquet Palomanes, Mattias Mattsson, Francesca Romana Mauro, Carlota Mayor-Bastida, Marta Morawska, Marina Motta, Talha Munir, Roberta Murru, Ivana Milosevic, Fatima Miras Calvo, Carsten Utoft Niemann, Jacopo Olivieri, Lorella Orsucci, Maria Papaioannou, Miguel Arturo Pavlovsky, Inga S. Piskunova, Barbara Pocali, Viola Maria Popov, Francesca Maria Quaglia, Giulia Quaresmini, Doreen te Raa, Gianluigi Reda, Gian Matteo Rigolin, Rosa Ruchlemer, Amit Shrestha, Martin Šimkovič, Martin Špaček, Paolo Sportoletti, Oana Stanca Ciocan, Tamar Tadmor, Elisabeth Vandenberghe, Marzia Varettoni, Candida Vitale, Ellen Van Der Spek, Michel Van Gelder, Ewa Wasik-Szczepanek, Lucrecia Yáñez, Mohamed A Yassin, Marta Coscia, Barbara Eichhorst, Alessandro Rambaldi, Niki Stavroyianni, Livio Trentin, Kostas Stamatopoulos, and Paolo Ghia
Subjects: Immunology, Cell Biology, Hematology, Biochemistry
Published: 2022

8. Role of fetal magnetic resonance imaging in fetuses with congenital cytomegalovirus infection: multicenter study

Author: Di Mascio, D., Rizzo, G., Khalil, A., D'Antonio, F., Di Mascio, Daniele, Rizzo, Giuseppe, Khalil, Asma, Giancotti, Antonella, Manganaro, Lucia, Visentin, Silvia, Cosmi, Erich, Prefumo, Federico, Stampalija, Tamara, D'Ambrosio, Valentina, Brunelli, Roberto, Liberati, Marco, Buca, Danilo, Matarrelli, Barbara, D'Amico, Alice, Oronzii, Ludovica, Tinari, Sara, Caulo, Massimo, Gentile, Luigia, Fantasia, Ilaria, Mappa, Ilenia, Maruotti, Giuseppe Maria, Saccone, Gabriele, Carbone, Luigi, Sarno, Laura, Bracalente, Gabriella, Bertucci, Emma, Sileo, Filomena Giulia, Pellegrino, Marcella, De Santis, Marco, Lanzone, Antonio, Pinelli, Lorenzo, Murru, Flora, Trincia, Elena, Pajno, Cristina, Sorrenti, Sara, Vasciaveo, Lorenzo, Nappi, Luigi, Greco, Pantaleo, D'Antonio, Francesco, Di Mascio, D., Rizzo, G., Khalil, A., D'Antonio, F., Di Mascio, Daniele, Rizzo, Giuseppe, Khalil, Asma, Giancotti, Antonella, Manganaro, Lucia, Visentin, Silvia, Cosmi, Erich, Prefumo, Federico, Stampalija, Tamara, D'Ambrosio, Valentina, Brunelli, Roberto, Liberati, Marco, Buca, Danilo, Matarrelli, Barbara, D'Amico, Alice, Oronzii, Ludovica, Tinari, Sara, Caulo, Massimo, Gentile, Luigia, Fantasia, Ilaria, Mappa, Ilenia, Maruotti, Giuseppe Maria, Saccone, Gabriele, Carbone, Luigi, Sarno, Laura, Bracalente, Gabriella, Bertucci, Emma, Sileo, Filomena Giulia, Pellegrino, Marcella, De Santis, Marco, Lanzone, Antonio, Pinelli, Lorenzo, Murru, Flora, Trincia, Elena, Pajno, Cristina, Sorrenti, Sara, Vasciaveo, Lorenzo, Nappi, Luigi, Greco, Pantaleo, and D'Antonio, Francesco
Subjects: Radiological and Ultrasound Technology, CMV, MRI, cytomegalovirus, hearing loss, infection, neurosonography, ultrasound, Obstetrics and Gynecology, General Medicine, Reproductive Medicine, Settore MED/40, Radiology, Nuclear Medicine and imaging
Abstract: To investigate the role of fetal brain magnetic resonance imaging (MRI) in detecting associated anomalies in fetuses with congenital cytomegalovirus (CMV) infection and normal neurosonography.This was a multicenter, retrospective cohort study of patients examined between 2012 and 2021 in 11 referral fetal medicine centers in Italy. Inclusion criteria were fetuses with congenital CMV infection diagnosed by polymerase chain reaction analysis of amniotic fluid, pregnancies that underwent detailed multiplanar ultrasound assessment of the fetal brain as recommended by the International Society of Ultrasound in Obstetrics and Gynecology, maternal age ≥ 18 years, normal fetal karyotype and MRI performed within 3 weeks after the last ultrasound examination. The primary outcome was the rate of central nervous system (CNS) anomalies detected exclusively on MRI and confirmed after birth or autopsy in fetuses with a prenatal diagnosis of congenital CMV infection and normal neurosonography at diagnosis. Additional CNS anomalies were classified into anomalies of the ventricular and the periventricular zone, intracranial calcifications in the basal ganglia or germinal matrix, destructive encephalopathy in the white matter, malformations of cortical development, midline anomalies, posterior fossa anomalies and complex brain anomalies. We evaluated the relationship between the incidence of structural CNS malformations diagnosed exclusively on fetal MRI and a number of maternal and gestational characteristics. Univariate and multivariate logistic regression analyses were used to identify and adjust for potential independent predictors of the MRI diagnosis of fetal anomalies.The analysis included 95 fetuses with a prenatal diagnosis of congenital CMV infection and normal neurosonography referred for prenatal MRI. The rate of structural anomalies detected exclusively at fetal MRI was 10.5% (10/95). When considering the type of anomaly, malformations of cortical development were detected on MRI in 40.0% (4/10) of fetuses, destructive encephalopathy in 20.0% (2/10), intracranial calcifications in the germinal matrix in 10.0% (1/10) and complex CNS anomalies in 30.0% (3/10). On multivariate logistic regression analysis, only CMV viral load in the amniotic fluid, expressed as a continuous variable (odds ratio (OR), 1.16 (95% CI, 1.02-1.21); P = 0.02) or categorical variable ( 100 000 copies/mL) (OR, 12.0 (95% CI, 1.2-124.7); P = 0.04), was independently associated with the likelihood of detecting fetal anomalies on MRI. Associated anomalies were detected exclusively at birth and missed by both prenatal neurosonography and fetal MRI in 3.8% (3/80) of fetuses with congenital CMV infection.Fetal brain MRI can detect additional anomalies in a significant proportion of fetuses with congenital CMV infection and negative neurosonography. Viral load in the amniotic fluid was an independent predictor of the risk of associated anomalies in these fetuses. The findings of this study support a longitudinal evaluation using fetal MRI in congenital CMV infection, even in cases with negative neurosonography at diagnosis. © 2022 International Society of Ultrasound in Obstetrics and Gynecology.
Published: 2023

9. Comparison analysis of the ETAS model with Gutenberg–Richter (GR), Tapered-GR and characteristic magnitude distributions

Author: I Spassiani, S Yaghmaei-Sabegh, R Console, G Falcone, and M Murru
Subjects: Geophysics, Geochemistry and Petrology
Abstract: SUMMARY In this paper, we carry out a comparison analysis of the Epidemic Type Aftershock Sequence (ETAS) model for the earthquake process, embedded with the three main exponential-type distributions adopted in practical applications to describe the magnitudes of seismic events, that are, the Gutenberg–Richter (GR), the tapered Gutenberg–Richter (TGR) and the CHaracteristic (CH) frequency–magnitude distributions (FMDs). The first law is a pure-power decreasing function, while both the other two introduce a more rapid decay in the tail of the distribution: a soft taper in the TGR model and a sharp cut-off in the CH one. To perform the comparison, we first investigate some theoretical features of the ETAS model with CH-distributed magnitudes (ETAS-CH), which have not been deeply analysed in the literature as much as for ETAS-TGR and ETAS-GR. In particular, we explicitly compute the branching ratio, we analyse its asymptotics in relation to its parameters, and we derive the proper stability conditions. We then move to the comparison among the three ETAS-GR, ETAS-TGR and ETAS-CH processes, to highlight differences and similarities. This is done by carrying out both a theoretical analysis, mainly focused on the three models’ branching ratios and the relative sensitivity, and a simulation analysis of realistic synthetic catalogues to compare the processes’ numbers, events’ magnitude distribution and temporal evolution. The results we obtained show that the ETAS-TGR and ETAS-CH processes have very similar features. They both have also less restrictive non-explosion conditions than for ETAS-GR; in fact, differently from this latter case, their branching ratios exist for any value of the parameters and are lower than the one of ETAS-GR, to which they converge for large magnitudes.
Published: 2022

10. «IN FORMA DI PAROLE». OSSERVAZIONI SUL LESSICO DELLA COMMEDIA

Author: Murru, Chiara
Abstract: Il principio della varietà è uno dei tratti che maggiormente definiscono la lingua di Dante e, specialmente, della Commedia: si tratta di un vocabolario estremamente ricco che spazia dai lessici tecnici delle scienze ai latinismi, dai vocaboli che esprimono le esperienze più concrete e quotidiane fino ai neologismi, significativi della grande creatività onomaturgica dantesca. Questo contributo nasce dalla volontà di mostrare le potenzialità di uno studio della ricchezza lessicale della Commedia condotto tramite il Vocabolario Dantesco: si propongono dunque alcuni risultati delle ricerche condotte nell’ambito del VD e si offrono approfondimenti relativi a un lessico tecnico, quello dell’anatomia e della medicina, al lessico della luce nel Paradiso e, infine, un caso specifico di variazione semantica, rappresentato dalle voci argento e oro, al fine di mostrare in che modo l’escursione dei significati si manifesti anche sulla base del progredire tematico e stilistico delle tre cantiche. ‘In the form of words’. Observations on the lexicon of Commedia The principle of variety is one of the most defining traits of Dante’s language and, especially, of the Commedia: it is an extremely rich vocabulary that ranges from the technical lexicons of the sciences to Latinisms, from words expressing the most concrete and everyday experiences to neologisms, significant of Dante’s great onomaturgical creativity. This article aims to show the potential of a study of the lexical richness of the Commedia conducted through Vocabolario Dantesco: some results of the research conducted within the VD are therefore proposed, and in-depth studies are offered on a technical lexicon, that of anatomy and medicine, on the lexicon of light in the Paradiso and, finally, on a specific case of semantic variation, represented by the words argento and oro, in order to show how the excursion of meanings is also manifested on the basis of the thematic and stylistic progression of the three cantica. &nbsp
Published: 2023

11. Antibody Response to the SARS-CoV-2 Vaccine and COVID-19 Vulnerability during the Omicron Pandemic in Patients with CLL: Two-Year Follow-Up of a Multicenter Study

Author: Francesca R. Mauro, Diana Giannarelli, Clementina M. Galluzzo, Andrea Visentin, Anna M. Frustaci, Paolo Sportoletti, Candida Vitale, Gianluigi Reda, Massimo Gentile, Luciano Levato, Roberta Murru, Daniele Armiento, Maria C. Molinari, Giulia Proietti, Sara Pepe, Filomena De Falco, Veronica Mattiello, Luca Barabino, Roberta Amici, Marta Coscia, Alessandra Tedeschi, Corrado Girmenia, Livio Trentin, and Silvia Baroncelli
Subjects: Cancer Research, Oncology, Omicron, chronic lymphocytic leukemia, COVID-19
Abstract: High morbidity and mortality due to COVID-19 were described in the pre-vaccination era in patients with chronic lymphocytic leukemia (CLL). To evaluate COVID-19 morbidity after the SARS-CoV-2 vaccine, we carried out a prospective study in 200 CLL patients. The median age of patients was 70 years; 35% showed IgG levels ≤ 550 mg/dL, 61% unmutated IGHV, and 34% showed TP53 disruption. Most patients, 83.5%, were previously treated, including 36% with ibrutinib and 37.5% with venetoclax. The serologic response rates to the second and third dose of the vaccine were 39% and 53%, respectively. With a median follow-up of 23.4 months, 41% of patients experienced COVID-19, 36.5% during the Omicron pandemic, and 10% had subsequent COVID-19 events. Severe COVID-19 requiring hospitalization was recorded in 26% of patients, and 4% died. Significant and independent factors associated with the response to the vaccine and vulnerability to COVID-19 were age (OR: 0.93; HR: 0.97) and less than 18 months between the start of targeted agents and vaccine (OR: 0.17; HR: 0.31). TP53 mutation and ≥two prior treatments also emerged as significant and independent factors associated with an increased risk of developing COVID-19 (HR: 1.85; HR: 2.08). No statistical difference in COVID-19 morbidity was found in patients with or without antibody response to the vaccine (47.5% vs. 52.5%; p = 0.21). Given the persistent risk of infection due to the continuous emergence of SARS-CoV-2 variants, our results support the importance of new vaccines and protective measures to prevent and mitigate COVID-19 in CLL patients.
Published: 2023
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12. Synthesis, in silico modelling, and in vitro biological evaluation of substituted pyrazole derivatives as potential anti-skin cancer, anti-tyrosinase, and antioxidant agents

Author: Samuel T. Boateng, Tithi Roy, Kara Torrey, Uchechi Owunna, Sergette Banang-Mbeumi, David Basnet, Eleonora Niedda, Alexis D. Alexander, Denzel El Hage, Siriki Atchimnaidu, Bolni Marius Nagalo, Dinesh Aryal, Ann Findley, Navindra P. Seeram, Tatiana Efimova, Mario Sechi, Ronald A. Hill, Hang Ma, Jean Christopher Chamcheu, and Siva Murru
Subjects: Pharmacology, Drug Discovery, General Medicine
Abstract: Twenty-five azole compounds (P1–P25) were synthesised using regioselective base-metal catalysed and microwave-assisted approaches, fully characterised by high-resolution mass spectrometry (HRMS), nuclear magnetic resonance (NMR), and infrared spectra (IR) analyses, and evaluated for anticancer, anti-tyrosinase, and anti-oxidant activities in silico and in vitro. P25 exhibited potent anticancer activity against cells of four skin cancer (SC) lines, with selectivity for melanoma (A375, SK-Mel-28) or non-melanoma (A431, SCC-12) SC cells over non-cancerous HaCaT-keratinocytes. Clonogenic, scratch-wound, and immunoblotting assay data were consistent with anti-proliferative results, expression profiling therewith implicating intrinsic and extrinsic apoptosis activation. In a mushroom tyrosinase inhibition assay, P14 was most potent among the compounds (half-maximal inhibitory concentration where 50% of cells are dead, IC50 15.9 μM), with activity greater than arbutin and kojic acid. Also, P6 exhibited noteworthy free radical-scavenging activity. Furthermore, in silico docking and absorption, distribution, metabolism, excretion, and toxicity (ADMET) simulations predicted prominent-phenotypic actives to engage diverse cancer/hyperpigmentation-related targets with relatively high affinities. Altogether, promising early-stage hits were identified – some with multiple activities – warranting further hit-to-lead optimisation chemistry with further biological evaluations, towards identifying new skin-cancer and skin-pigmentation renormalising agents.
Published: 2023

13. Modeling <scp>PCDH19</scp> clustering epilepsy by Neurogenin 2 induction of patient‐derived induced pluripotent stem cells

Author: Diana Alaverdian, Anna Margherita Corradi, Bruno Sterlini, Fabio Benfenati, Luca Murru, Maria Passafaro, Jlenia Brunetti, Ilaria Meloni, Francesca Mari, Alessandra Renieri, and Elisa Frullanti
Subjects: PCDH19, Neurology, iPSCs, neurons, Neurology (clinical), General Medicine, neuronal progenitor cells, disease modelling
Published: 2023

14. Design of Fluorescent Carbon Dots (CDs) for the Selective detection of Metal‐Containing Ions

Author: Alejandro López‐Beltrán, Claudia Iriarte‐Mesa, Clarissa Murru, Frank J. Chao‐Mujica, Angel Luis Corcho‐Valdés, Lisandra Morales‐Álvarez, Luis Felipe Desdín‐García, Johnny Deschamps, and Manuel Antuch
Subjects: Organic Chemistry, General Chemistry, Catalysis
Published: 2023

15. Conclusion

Author: Sandra Clare, Christine Parker, Joanne Benford, Caroline Griffiths, Antonio Griffiths-Murru, and Katherine Clark
Published: 2023

16. What is hidden in the luggage? First assessments of illegal seashells gathering in <scp>S</scp> ardinia ( <scp>I</scp> taly)

Author: Stefania Coppa, Andrea Camedda, Giorgio Massaro, Sara Vencato, Franco Murru, Maria Tiziana Pinna, Davide Urrai, Antonio Casula, Maurizio Riccitelli, and Giuseppe Andrea de Lucia
Subjects: Global and Planetary Change, Ecology, Environmental Science (miscellaneous), Nature and Landscape Conservation
Published: 2023

17. Adolescent with recurrent knee pain

Author: Giorgio Cozzi, Flora Maria Murru, Michele Mazzolai, Egidio Barbi, Ingrid Rabach, Mazzolai, M., Murru, F. M., Rabach, I., Barbi, E., and Cozzi, G.
Subjects: medicine.medical_specialty, business.industry, Osteomyelitis, osteomyelitis, pyoderma gangrenosum, medicine.disease, Surgery, Knee pain, Pediatrics, Perinatology and Child Health, medicine, medicine.symptom, business, Pyoderma gangrenosum
Abstract: N/A
Published: 2022

18. Occurrence and distribution of Salmonella serovars in carcasses and foods in southern Italy: Eleven-year monitoring (2011–2021)

Author: Maria Francesca Peruzy, Yolande Thérèse Rose Proroga, Federico Capuano, Andrea Mancusi, Angela Michela Immacolata Montone, Daniela Cristiano, Anna Balestrieri, Nicoletta Murru, Peruzy, Maria Francesca, Proroga, Yolande Thérèse Rose, Capuano, Federico, Mancusi, Andrea, Montone, Angela Michela Immacolata, Cristiano, Daniela, Balestrieri, Anna, and Murru, Nicoletta
Subjects: Microbiology (medical), Salmonella occurrence in food, S. Infanti, monophasic S. Typhimurium, Salmonella occurrence in carcasses of food-producing animal, Salmonella serovar, S. Typhimurium, Microbiology
Abstract: Salmonella is one of the most common agents of foodborne illness. The genus Salmonella includes two species (Salmonella bongori and S. enterica) and six subspecies (enterica I, salamae II, arizonae IIIa, diarizonae IIIb, houtenae IV, and indica VI), each of which contains multiple serotypes associated with animal and human infections. The aim of the study was to evaluate the presence of Salmonella spp. in carcasses of food-producing animals and foods in southern Italy and the serovar distribution among different sources. From 2011 to 2021, a total of 12,246 foods and 982 samples from animal carcasses were collected and analyzed. The overall percentage of positive samples was 5.84% (N = 773) and a significant increase in prevalence was observed by comparing the years 2011–2015 (257, 3.27%) and 2016–2021 (516, 9.61%; p < 0.05). The highest percentage of positive food samples was observed in “Meat and Meat Products” (N = 327/2,438, 13.41%) followed by “Fish and fishery products” (N = 115/1,915, 6.01%). In carcasses, the highest percentage of positive samples was reported from broilers (N = 42/81, 51.85%) followed by buffalo (N = 50/101, 49.50%) and pork (N = 140/380, 36.84%). After typing, the isolates were assigned to the species S. enterica and to the subspecies: enterica (N = 760, 98.32%), diarizonae (N = 8, 1.03%), salamae (N = 3, 0.39%) and houtenae (N = 2, 0.26%). S. Infantis was the most frequently detected (N = 177, 24.76%), followed by S. Derby (N = 77, 10.77%), monophasic S. Typhimurium (N = 63, 8.81%), S. Typhimurium (N = 54, 7.55%), and S. Rissen (N = 47, 6.57%). By comparing the sampling period 2011–2015 with that of 2016–2021, an increase in the prevalence of S. Infantis and monophasic S. Typhimurium and a decrease of S. Typhimurium were recorded (p < 0.05). Thus, present data suggest that, despite the implementation of national and European control strategies to protect against Salmonella, the prevalence of this pathogen in southern Italy is still increasing and a change of national control programs to protect against Salmonella are necessary.
Published: 2022

19. Impact of COVID-19 Pandemic Waves on Outcomes of Patients with Previously Untreated Advanced Follicular Lymphoma Enrolled in the Urban Ambispective Study in Italy

Author: Antonio Pinto, Emanuele Guardalben, Marica Battista, Giulia Chiara Gazzoli, Michele Merli, Annalisa Chiarenza, Tommasina Perrone, Attilio Guarini, Nicola Di Renzo, Carlo Visco, Agostino Tafuri, Roberta Murru, Felicetto Ferrara, Jacopo Olivieri, Attilio Olivieri, Andrés J M Ferreri, Marco Ladetto, Pier Luigi Zinzani, Luca Arcaini, and Giuseppe Gritti
Subjects: Immunology, Cell Biology, Hematology, Biochemistry
Published: 2022

20. How Age, Comorbidities and Concomitant Medications Influence Ibrutinib Management and Survival in Waldenstrom Macroglobulinemia

Author: Annamaria Frustaci, Francesco Piazza, Simone Ferrero, Gianluigi Reda, Rita Rizzi, Lorella Orsucci, Isacco Ferrarini, Marina Deodato, Luca Laurenti, Benedetta Puccini, Claudia Baratè, Marzia Varettoni, Michele Merli, Emanuele Cencini, Antonino Greco, Guido Gini, Angela Ferrari, Chiara Borella, Enrico Lista, Massimo Gentile, Roberta Murru, Marina Motta, Francesca Rezzonico, Monica Tani, Paolo Sportoletti, Giulia Zamprogna, Valter Torri, Roberto Cairoli, and Alessandra Tedeschi
Subjects: Immunology, Cell Biology, Hematology, Biochemistry
Published: 2022

21. Immune Response to Covid-19 Vaccination in Patients with Chronic Lymphocytic Leukaemia (CLL): An Experience from Two Italian Centres

Author: Idanna Innocenti, Roberta Murru, Giulia Benintende, Andrea Galitzia, Antonio Mosca, Luca Barabino, Luca Stirparo, Annamaria Tomasso, Alberto Fresa, Francesco Autore, Giovanni Caocci, Giorgio La Nasa, and Luca Laurenti
Subjects: Immunology, Cell Biology, Hematology, Biochemistry
Published: 2022

22. Real-World Outcome of Treatment with Single-Agent Ibrutinib in Patients with Chronic Lymphocytic Leukemia: Results from the Italian Study Evidence

Author: Stefano Molica, Potito Rosario Scalzulli, Lydia Scarfò, Attilio Guarini, Roberta Murru, Paolo Sportoletti, Ferdinando Frigeri, Francesco Albano, Nicola Di Renzo, Alessandro Sanna, Idanna Innocenti, Massimo Massaia, Marta Coscia, Elsa Pennese, Caterina Patti, Gianluigi Reda, Agostino Tafuri, Giulia Regazzoni, Michele Di Candia, and Francesca Romana Mauro
Subjects: Immunology, Cell Biology, Hematology, Biochemistry
Published: 2022

23. Basal serum level of Δ4-androstenedione reflects the ovaries’ ability to respond to stimulation in IVF cycles: setting up a new reliable index of both ovarian reserve and response

Author: Emanuele Garzia, Valentina Galiano, Laura Guarnaccia, Giovanni Marfia, Giulia Murru, Ellade Guermandi, Jennifer Riparini, Patrizia Sulpizio, and Anna Maria Marconi
Subjects: Anti-Mullerian Hormone, Follicular Atresia, Ovary, Androstenedione, Reproducibility of Results, Obstetrics and Gynecology, Fertilization in Vitro, General Medicine, Ovarian Follicle, Ovulation Induction, Reproductive Medicine, Androgens, Genetics, Humans, Female, Follicle Stimulating Hormone, Ovarian Reserve, Gonadotropins, Genetics (clinical), Developmental Biology
Abstract: Adequate androgen levels are necessary for regular follicular growth, progression beyond the pre-antral stage, and prevention of follicular atresia. The main purpose of this study was to investigate whether baseline androgen levels had a predictive value on stimulation outcomes in IVF cycles. The secondary purpose was to compare the possible predictive value of androgens with that of already known markers.The study included 91 infertile patients aged 30-45 years awaiting the first IVF cycle. All women underwent the same stimulation protocol and the same starting dose of recombinant FSH. As stimulation outcomes, the number of follicles recruited, estradiol and progesterone levels on the day of trigger, the total dose of gonadotropins administered, and the number of oocytes collected were recorded. Multiple linear regression and multivariate logistic regression were used to evaluate the significant predictive value of the variables for response to controlled ovarian stimulation (COS). By studying the reliability of different markers, an attempt was made to develop a single index with the highest predictive value.Pearson's correlation revealed a statistically significant inverse correlation between oocytes collected and age (r = - 0.333, p 0.001) and a positive correlation with AMH (anti-müllerian hormone) (r = 0.360, p 0.001), antral follicle count (AFC) (r = 0.639, p 0.001), and androstenedione (Δ4-A) (r = 0.359, p 0.001). No significant correlation was reported with FSH (r = - 0.133, p = 0.207) and total testosterone (r = 0.180, p = 0.088). In COS good responders, the G-index (= AMH ng/mL*AFC/Δ4-A ng/dL) revealed a significantly higher level (p 0.001) than AMH, AFC, and Δ4-A alone.Baseline serum Δ4-A, presumably crucial for ensuring a regular follicular growth, is a reliable marker of ovarian response to stimulation. Since the ovarian capacity to respond to gonadotropins does not depend exclusively on the presence of follicles, we suggest a new index, the G-index, able to contemplate both the ovarian reserve and the Δ4-A level.
Published: 2022

24. Stress concentration due to an elliptic hole in a porous elastic plate

Author: Bhaskar Vajipeyajula, Pavitra Murru, and Kumbakonam Ramamani Rajagopal
Subjects: Mechanics of Materials, General Mathematics, General Materials Science
Abstract: We study the state of stress and strain in a square plate containing an elliptic hole in the case of a porous elastic solid undergoing small strain, using a constitutive relation that has been put into place recently to describe the response of such solids undergoing small strains. We carry out the study by solving the problem numerically. We verify that our numerical solutions agree with those for the classical linearized elastic solid when certain appropriate material parameters are set to zero. We show that the stress concentration factor in the case of the porous elastic solid can be much higher, as much as 300% of the stress concentration in the case of the classical linearized elastic solid, when the aspect ratio is sufficiently small, depending on the values of certain material parameters. The difference between the stress concentration for the porous solid increases as the aspect ratio (the ratio of the major axis to the minor axis) decreases. By allowing the aspect ratio of the ellipse to go to zero, we can obtain the state of stress and strain adjacent to a crack in the square plate; however, in this limit, the strains would greatly exceed the assumption under which the constitutive theory is derived.
Published: 2022

25. Severe onset of inflammatory myositis in a child: think to paraneoplastic myositis

Author: Federico Poropat, Flora Maria Murru, Giulia Gortani, Marco Carrozzi, Rossana Bussani, Simone Benvenuto, Alberto Tommasini, Andrea Taddio, Benvenuto, S., Gortani, G., Bussani, R., Poropat, F., Murru, F. M., Carrozzi, M., Tommasini, A., and Taddio, A.
Subjects: 0301 basic medicine, myalgia, Parenteral Nutrition, Necrotizing myopathy, Case Report, Meningocele, Gastroenterology, Pediatrics, Tracheostomy, 0302 clinical medicine, Physical Therapy Modalitie, Diagnosis, Myositi, Child, Myositis, Tumor, Cancer-associated myopathy, medicine.diagnostic_test, Teratoma, Combined Modality Therapy, Magnetic Resonance Imaging, Combination, Drug Therapy, Combination, Female, medicine.symptom, Rituximab, Human, medicine.medical_specialty, Physical examination, Malignancy, RJ1-570, Diagnosis, Differential, Inflammatory myopathy, 03 medical and health sciences, Drug Therapy, Internal medicine, Biomarkers, Tumor, medicine, Humans, Myopathy, Physical Therapy Modalities, 030203 arthritis & rheumatology, IVIG, Noninvasive Ventilation, Muscle biopsy, business.industry, Anti-TIF1- γ, medicine.disease, 030104 developmental biology, Respiratory failure, Differential, business, Biomarkers
Abstract: Background Juvenile idiopathic inflammatory myopathies (JIIMs) are a group of heterogenous, acquired, autoimmune disorders that affect the muscle. While the association between IIMs and malignancy has been widely reported in adults, cancer-associated myositis (CAM) is rare in children, so that routine malignancy screening is not generally performed. This report shows a case of severe CAM in a child. Case presentation An 11-years-old girl presented with worsening dyspnea after a 3-weeks history of progressive proximal weakness, myalgia, dysphagia, and weight loss. Her past history was remarkable for a type I Arnold-Chiari malformation associated with an anterior sacral meningocele. Physical examination showed severe hypotony and hypotrophy. Pulse oximetry and blood test showed a type II respiratory failure (SpO2 88%, pCO2 68 mmHg) and increased muscle enzyme levels (CPK 8479 U/L, AST 715 U/L, ALT 383 U/L, LDH 1795 U/L). The patient needed invasive mechanical ventilation. Inflammatory myositis was considered and treatment with intravenous methylprednisolone (30 mg/Kg/day for 3 days followed by 2 mg/Kg/day) and IVIG (1 g/kg/day for 2 days) was started. Muscle biopsy showed endomysial and perimysial necrosis and inflammation. The presence of serum anti-TIF1-γ antibody positivity led to a malignancy screening. Whole-body MRI showed a mature teratoma underneath sacral meningocele and both lesions were surgically removed. Given the histological and clinical severity of the myopathy, mycophenolate (500 mg twice a day) and rituximab (360 mg/m2, 4 weekly infusions) were added. Due to extreme muscular wasting, severe malnutrition and intolerance to enteral feeding the patient needed a transient tracheostomy and parenteral nutrition, followed by physiotherapy, speech therapy and nocturnal non-invasive ventilation. A complete remission was achieved 3 months after. Conclusions Among cancer-associated autoantibodies (CAAs) in adult patients, anti-TIF1-γ carries the highest risk of CAM, which recognizes with a high likelihood a paraneoplastic pathogenesis. In children, anti-TIF1-γ antibody has been associated with severe cutaneous disease, lipodystrophy, and chronic disease course, but not with CAM, which is overall rare in younger patients. Severe onset of a JIIM, especially if anti-TIF1-γ antibody positive, should prompt suspect of a CAM and lead to a screening for malignancy.
Published: 2021

26. P-adic continued fractions for number fields

Author: Capuano, Laura, Murru, Nadir, Terracini, Lea, S. Barbero, D. Bazzanella, L. Capuano, A. Mori, N. Murru, C. Sanna, Capuano, Laura, Murru, Nadir, and Terracini, Lea
Published: 2022

27. Machine Learning Prediction of Comorbid Substance Use Disorders among People with Bipolar Disorder

Author: Vincenzo Oliva, Michele De Prisco, Maria Teresa Pons-Cabrera, Pablo Guzmán, Gerard Anmella, Diego Hidalgo-Mazzei, Iria Grande, Giuseppe Fanelli, Chiara Fabbri, Alessandro Serretti, Michele Fornaro, Felice Iasevoli, Andrea de Bartolomeis, Andrea Murru, Eduard Vieta, Giovanna Fico, Oliva, V., De Prisco, M., Pons-Cabrera, M. T., Guzman, P., Anmella, G., Hidalgo-Mazzei, D., Grande, I., Fanelli, G., Fabbri, C., Serretti, A., Fornaro, M., Iasevoli, F., de Bartolomeis, A., Murru, A., Vieta, E., Fico, G., Oliva, Vincenzo, De Prisco, Michele, Pons-Cabrera, Maria Teresa, Guzmán, Pablo, Anmella, Gerard, Hidalgo-Mazzei, Diego, Grande, Iria, Fanelli, Giuseppe, Fabbri, Chiara, Serretti, Alessandro, Fornaro, Michele, Iasevoli, Felice, de Bartolomeis, Andrea, Murru, Andrea, Vieta, Eduard, and Fico, Giovanna
Subjects: Substance abuse, bipolar disorder, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Trastorn bipolar, substance use disorder, cannabis use disorder, General Medicine, alcohol use disorder, Abús de substàncies, Alcoholism, All institutes and research themes of the Radboud University Medical Center, machine learning, Alcoholisme, Cànnabis, Aprenentatge automàtic, Machine learning, Drogoaddicció, Manic-depressive illness, Drug addiction, Cannabis
Abstract: Substance use disorder (SUD) is a common comorbidity in individuals with bipolar disorder (BD), and it is associated with a severe course of illness, making early identification of the risk factors for SUD in BD warranted. We aimed to identify, through machine-learning models, the factors associated with different types of SUD in BD. We recruited 508 individuals with BD from a specialized unit. Lifetime SUDs were defined according to the DSM criteria. Random forest (RF) models were trained to identify the presence of (i) any (SUD) in the total sample, (ii) alcohol use disorder (AUD) in the total sample, (iii) AUD co-occurrence with at least another SUD in the total sample (AUD+SUD), and (iv) any other SUD among BD patients with AUD. Relevant variables selected by the RFs were considered as independent variables in multiple logistic regressions to predict SUDs, adjusting for relevant covariates. AUD+SUD could be predicted in BD at an individual level with a sensitivity of 75% and a specificity of 75%. The presence of AUD+SUD was positively associated with having hypomania as the first affective episode (OR = 4.34 95% CI = 1.42–13.31), and the presence of hetero-aggressive behavior (OR = 3.15 95% CI = 1.48–6.74). Machine-learning models might be useful instruments to predict the risk of SUD in BD, but their efficacy is limited when considering socio-demographic or clinical factors alone.
Published: 2022

28. Validation of the OAKS prognostic model for acute kidney injury after gastrointestinal surgery

Author: Ahmed, W. U. R., Bhatia, S., Mclean, K. A., Khaw, R., Baker, D., Kamarajah, S. K., Bell, S., Nepogodiev, D., Harrison, E. M., Glasbey, J. C., Borakati, A., Burke, J., Drake, T. M., Bath, M. F., Claireaux, H. A., Gundogan, B., Mohan, M., Deekonda, P., Kong, C., Joyce, H., Mcnamee, L., Woin, E., Khatri, C., Fitzgerald, J. E., Bhangu, A., Arulkumaran, N., Duthie, F., Hughes, J., Pinkney, T. D., Prowle, J., Richards, T., Thomas, M., Blanco-Colino, R., Chapman, S. J., Pata, F., Pellino, G., Sgr??, A., Soares, A., van Elst, T., Van Straten, S., Knowles, C. H., Dynes, K., Patel, M., Patel, P., Wigley, C., Suresh, R., Shaw, A., Klimach, S., Jull, P., Evans, D., Preece, R., Ibrahim, I., Manikavasagar, V., Smith, R., Brown, F. S., Teo, R., Sim, D. P. Y., Logan, A. E., Barai, I., Amin, H., Suresh, S., Sethi, R., Gul, W., Bolton, W., Corbridge, O., Horne, L., Attalla, M., Morley, R., Robinson, C., Hoskins, T., Mcallister, R., Lee, S., Dennis, Y., Nixon, G., Heywood, E., Wilson, H., Ng, L., Samaraweera, S., Mills, A., Doherty, C., Belchos, J., Phan, V., Lim, M., Miller, F. A., Chouari, T., Gardner, T., Goergen, N., Hayes, J. D. B., Macleod, C. S., Mccormack, R., Mckinley, A., Mckinstry, S., Milligan, W., Ooi, L., Rafiq, N. M., Sammut, T., Sinclair, E., Smith, M., Wong, J., Ablett, A. D., Tie-Gill, T., Ramsay, G., De Paola, L., Mcguckin, S., Alshakhs, A., Ahmeidat, A., Francis, A. A., Baker, C., Boulton, A. P. R., Collins, J., Copley, H. C., Fearnhead, N., Fox, H., Mah, T., Mckenna, J., Naruka, V., Nigam, N., Nourallah, B., Perera, S., Qureshi, A., Saggar, S., Sun, L., Wang, X., Yang, D. D., Ali, Z., Mullarkey, L., Walshe, R., Lewis, E., Berry, B., Moneim, J., Mookerjee, S., Al-hadithi, A., Caroll, P., Doyle, C., Elangovan, S., Falamarzi, A., Gascon Perai, K., Greenan, E., Jain, D., Lang-Orsini, M., Lim, S., O'Byrne, L., Ridgway, P., Van der Laan, S., Arthur, J., Barclay, J., Bradley, P., Edwin, C., Finch, E., Hayashi, E., Hopkins, M., Kelly, D., Kelly, M., Mccartan, N., Ormrod, A., Pakenham, A., Christy, S., Hayward, J., Hitchen, C., Kishore, A., Martins, T., Philomen, J., Rao, R., Rickards, C., Burns, N., Copeland, M., Durand, C., Dyal, A., Ghaffar, A., Gidwani, A., Grant, M., Gribbon, C., Gruhn, A., Leer, M., Ojofeitimi, O., Carroll, L., Hylands, A., Delaugere, L. P., Reveendran, D., Ahmad, K., Beattie, G., Beatty, M., Campbell, G., Donaldson, G., Graham, S., Holmes, D., Kanabar, S., Liu, H., Mccann, C., Stewart, R., Vara, S., Coulter, C., Ralston, C., Laverty, L., Gallagher, P., Ajibola-Taylor, O., Andah, E. J. E., Ani, C., Cabdi, N. M. O., Ito, G., Jones, M., Komoriyama, A., Titu, L., Ahmed, A., Yeo, Y. Q., Elliott, D., Bennett, J., Mcnamara, M., Sivarajah, S., Dunmore, C., Basra, M., Gallogly, P., Harinath, G., Leong, S. H., Pradhan, A., Siddiqui, I., Zaat, S., Ali, A., Galea, M., Looi, W. L., J. C. K., Ng, Farhan-Alanie, M. M. H., Aitken, G., Nair, M., Aly, M. H., Buari, M., Atkin, G., Azizi, A., Cargill, Z., China, Z., Elliot, J., Jebakumar, R., Lam, J., Mudalige, G., Onyerindu, C., Renju, M., Shankar Babu, V., Ahmed, K., Sheikh, Z., Monks, M., Lehmann, J., Rotimi, O., Hussain, M., Joji, N., Lovett, B., Mownah, H., Dwyer-Hemmings, L., Busuttil, A., Powell, J., Hensher, C., Vivian, F., Ali, B., Cresswell, B., Dhillon, A. K., Dupaguntla, Y. S., Hungwe, C., Lowe-Zinola, J. D., Tsang, J. C. H., Wcislo, K., Bevan, K., Cardus, C., Duggal, A., Hossain, S., Mchugh, M., Scott, M., Millar, Z., Hirosue, S., Ogunmwonyi, I., Nakakande, D., Chan, F., Evans, R., Gurung, E., Haughey, B., Jacob-Ramsdale, B., Kerr, M., Lee, J., Mccann, E., O'Boyle, K., Reid, N., Kwek, I., Gaze, H., Nirmalanantha, A., Bin Amran, M. A., Foulkes, A., Jones, N., Lau, I. S. F., Hayat, F., Hodgson, S., Johnston, R., Jones, W., Khan, M., Linn, T., Long, S., Seetharam, P., Shaman, S., Smart, B., Pillai, S., Khoury, G., Powell, T., Maleyko, I., Sangheli, A., Ransome, M., Isse, M., Aromolaran, O., Bholah, H., Anilkumar, A., Davies, J., Griffith, J., Hughes, B., Islam, Y., Kidanu, D., Mushaini, N., Qamar, I., Robinson, H., Schramm, M., Yan Tan, C., Murray, V., Theocharidou, L., Malik, T., Janmohamed, I., Carhart, B., Khan, A., Apperley, H., Billyard, C., Blazeby, J. M., Cannon, S. P., Carse, S., G??pfert, A., Loizidou, A., Parkin, J., Sanders, E., Sharma, S., Slade, G., Telfer, R., Whybrow Huppatz, I., Worley, E., Asif, A., Hullait, R., Quinn, P., Rylance, A., Butt, S., Leathes, J., Chandramoorthy, L., Friend, C., Harris, L., Jain, P., Karim, M. J., Killington, K., Mcgillicuddy, J., Rafferty, C., Rahunathan, N., Rayne, T., Varathan, Y., Verma, N., Zanichelli, D., Arneill, M., Brown, F., Campbell, B., Crozier, L., Henry, J., Mccusker, C., Prabakaran, P., Wilson, R., Karelia, S., Clements, J. M., Rainey, M., Asif, U., Connor, M., Dindyal, S., Math, N., Pagarkar, A., Saleem, H., Seth, I., Standfield, N., Swartbol, T., Adamson, R., Choi, J. E., El Tokhy, O., Ho, W., Javaid, N. R., Mehdi, A. S., Menon, D., Plumptre, I., Sturrock, S., Turner, J., Warren, O., Joshi, N., Rahman, A., Gallagher, M., Crane, E., Ferris, B., Gadsby, C., Smallwood, J., Vipond, M., Wilson, V., Amarnath, T., Doshi, A., Gregory, C., Kandiah, K., Powell, B., Spoor, H., Toh, C., Vizor, R., Rebuffa, N., Abdelgalil, R., Siaw Yen Lai, R., Smith, E., Common, M., Dunleavy, K., Harris, S., Luo, C., Mesbah, Z., Prem Kumar, A., Redmond, A., Skulsky, S., Walsh, T., Daly, D., Deery, L., Epanomeritakis, E., Harty, M., Kane, D., Khan, K., Mackey, R., Mcconville, J., Mcginnity, K., Wong, H. L., Ang, A., Kee, J. Y., Leung, E., Norman, S., Palaniappan, S. V., Partha Sarathy, P., Yeoh, T., Frost, J., Hazeldine, P., Jones, L., Karbowiak, M., Macdonald, C., Mutarambirwa, A., Omotade, A., Runkel, M., Ryan, G., Sawers, N., Searle, C., Vig, S., Hlukha, L., Pike, G., Kamel, F., Thakkar, R., Mcauliffe, O., Ahmad, A., Mcgartland, R., Sim, R., Song, A., Wayman, J., Brown, R., Chang, L. H., Concannon, K., Crilly, C., Arnold, T. 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H., Majeed, Y., Fakim, B., Donnelly, C., Begum, F., Best, R., Collishaw, A., Glasbey, J., Golding, D., Gwilym, B., Harrison, P., Jackman, T., Lewis, N., Luk, Y. L., Porter, T., Potluri, S., Stechman, M., Tate, S., Thomas, D., Walford, B., Auld, F., Bleakley, A., Johnston, S., Jones, C., Khaw, J., Milne, S., O'Neill, S., Singh, K. K. R., Swan, A., Thorley, N., Yalamarthi, S., Yin, Z. D., Balian, V., Bana, R., Clark, K., Livesey, C., Mclachlan, G., Mohammad, M., Pranesh, N., Richards, C., Ross, F., Sajid, M., Liversedge, G., Carrington, Z., Windebank, J., Izzarina, A., Akbani, U., Craven, J., Aldarragi, A., Harding, S., Millward, A., Brooke, M., Francombe, J., Gresly, J., Hutchinson, S., Kerrigan, K., Matthews, E., Nur, S., Parsons, L., Sandhu, A., Vyas, M., White, F., Zulkifli, A., Zuzarte, L., Shortland, T. 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K., Ashworth, I., Nelson, L., Ratnasingham, D., Adeogun, A., Carr, R., Davison, C., Devalia, S., Hayat, A., Karsan, R. B., Osborne, C., Weegenaar, C., Wijeyaratne, M., Curran, M., Horner, C., Babatunde, F., Barnor-Ahiaku, E., Chitsabesan, P., Dixon, O., Hall, N., Ilenkovan, N., Mackrell, T., Nithianandasivam, N., Orr, J., Palazzo, F., Saad, M., Sandland-Taylor, L., Sherlock, J., Ashdown, T., Chandler, S., Garsaa, T., Lloyd, J., Loh, S. Y., Ng, S., Perkins, C., Underhill, R., Arthur, T., Ng, J., Kovacevic, M., Delibegovic, S., Karamanliev, M., Ivanov, T., Yotsov, T., Ilieva, I., Akisheva, A., Shoshkova, M., Nawaz, E., Swamad, M., Neykov, V., ebr??k, R., Paramasivam, R., Martensen HM Larsen HM Larsen, A., R??deker, L., Frey, P. E., Kechagias, A., Turunen, A., Katunin, J., Niskakangas, M., Ojak????r, A., Venara, A., Lenaoures, P., Duchalais, E., Vignaud, T., Frey, S., Ricolleau, C., Ioannidis, A., Konstantinidis, M., Antonakopoulos, F., Mathioulaki, A., Chrysoheris, P., Athanasopoulos, P. G., Koutserimpas, C., Tenconi, S. M., Rausei, S., Maioli, D., Marchionini, V., Pasquali, S., Simioni, A., Farina, V., Podda, M., Lorenzon, L., Tirelli, F., Fico, V., Santullo, F., Belia, F., Schaeff, V., Otto, A., Jakubauskas, M., Po??kus, E., Danys, D., Kry??auskas, M., Mikalauskas, S., Rackauskas, R., Drungilas, M., Po??kus, T., Jotautas, V., Strupas, K., Petrulionis, M., van Elst, T. R., Abdulrahman, Z., Chu, M., Fagan, P. V. B., Wells, C. I., Alagoa Jo??o, A., Apar??cio, D. J., Fragoso, M., Guimar??es, J., Cruz, G., Ribeiro, J., Borges da Ponte, I., Almeida, S., Martins, A. R., Juloski, J., Cuk, V. V., Radulovic, R., Milo??evic, K., Bojicic, J., Gencic, M., Jankovic, U., Jovanovic, M., El Kasmy El Kasmi, Y., G??mez Jurado, M. J., Alberti Delgado, P., Bordanova Reverter, A., G??mez del Pulgar, A., Belzunce-Cap??, J. F., Verdaguer Tremolosa, M., Lin, Q., P??rez-Ajates, S., Ramayo D??az, N., Gonz??lez Caraballo, I., Pascual Vicente, T., Orue-Echebarria, M. I., S??nchez-Calvo, L., Wang, D., Trueba-Collado, C., Morales Bernaldo de Quir??s, J. T., Anabitarte Bautista, O., Yebes, A., Espin-Basany, E., Clerc, D., Mignon, G., Vanoni, A., Henkens, A., Jarrar, G., Odovic, M., Willemin, M., Milliet, O., Hahnloser, D., Demartines, N., Curchod, P., Ciubotaru, C., Popescu, S., Popescu, S. S., Piras, K., Ciubotaru, C. I., Yanishev, A., Luzan, R., Lutovinova, E., Gavrilina, A., Barkovskaya, A., Kudelkina, N., Topchubaev, D., Ozkan, B. B., Yagiz Sen, A., Aktas, M. K., Aykun, N., Agca, M. H., Bilen, C., Kilinc, I., Atar, C., Kilic, V., Aktuna, C., Aba, M., Eray, I. C., Baki, B. E., Arslan, E., Alemdag, G., Ulusahin, M., Gul, E. B., Yildirim, R., Semiz, A., Bektur, G., Tomas, K., Bodur, S., Y??ksek, B., Serin, H., Erd??nmez, H., G??rsoy, F., Kara, H., nsal, U., zbek, M., Kasar, P. A., Ipor, A., etin, M. F., Khaw, R. A., Mills, E., Manley, L. R., Vutipongsatorn, K., Thakral, N., Adra, M., Khan, S. M., Badran, A., Ramjeeawon, A., Tan, H. L., Rye, D. S., Rajaraman, N., Norman, J. G., Solomou, G., Baker, D. M., Brandao, B. D., Stainer, B., Onafowokan, O. O., Gharooni, A., Dabab, N., Carlton-Carew, S., Kungwengwe, G., Gabriel, M., Sewart, E., Lawday, S, Pockney, P., Chrimes, A., Agarwal, A., Zhao, J., Jayalath, J. M. S. N., Liebenberg, P., Khor, S., Muddasani, T., Dawson, A., Taylor, N., Stevenson, C., Drane, A., Pahalawatta, U., Lai, L. T., Debiasio, A., Jung, M., Brumfitt, C. D., Beh, Y. Z., Dudi-Venkata, N. N., Lee, Y. D., Stewart, P., Thirugnanasundralingam, V., Muir, K., Ng, B., Mendis, D. M., Robb, P. M., Lee, H. J., Wyche, A. A. B., Davis, L. T., Luong, J. K., Jegathees, T., Coulter-Nile, S. M. C. J., Gosselink, M. P., Wang, Y. L., Maciaszek, M., Chrapko, P. S., White, S., Ivanov, V., Borisova, A., Kuncarov??, K., Ri??ko, J., Ludvik, M., Stercz, M., Treskon, R., Posp????il, M., Hlav??cov??, L., Tomanov??, D., Kolo??ov??, B., Sobotkov??, K., Cha, S., uta Kimle, K., Jirankova, K., Bujda, M., Pacl??k, A., Chrz, K., Antonova, T., Chodora, S., Houdek, O., Novick??, R., Skalick??, A., Farka??ov??, M., Jozaf, V., Klail, T., Prochazka, V., Harbjerg, J. L., Enevoldsen, M., H??jgaard Pedersen, J., Brandsborg, S., Amiri, S., Brinck, S., Jepsen, B. N., Hillgaard, T. K., Erichsen, S. B., Nielsen, C. V., Madsen, C. P., Bjerke, J., Skej??, C. D., Aabling, R. R., Kjaer, M. D., Unbehaun, K. P., Mark-Christensen, A., Dalsgaard, P., Trap, A., J??rgens-Lahnstein, J., Storm, M., Damgaard, I., Olawi, F., Ehlern, F., Raos, M., Ravn, S., Lycke, K. D., Kristensen, F. P., B??nnerup, K., Brigand, C., Dumange, E., Gout, M., Moehwald, C., Prem, M., Krupp, J., Alhalabi, O., Sliwinski, S., Gablenz, E., Seiboldt, T., Beck, L., Pohl, L. J., Zamzow, K., Betge, F., Poncelet, A., Truant, M., Hauschild, H., Neugebauer, N., D??rr-Harim, C., Schmitzer, L., Kopp, A., Steinle, J., Gsenger, J., Riccardi, M., Christodoulou, I. M., Zoikas, A., Machairas, N., Paspala, A., Papaconstantinou, D., Spartalis, E., Arkadopoulos, N., Prodromidou, A., Garoufalia, Z., Balalis, D., Manatakis, D. K., Kalles, V., Spyrou, I., Barkolias, C., Aguilera, M. L., Mendez, D., Rosales, J., Flores, M., Garcia, M., Garcia, A., Noriega, Z., Torselli, D., Rodriguez, J., Argenti, F., Milani, M. S., Malabarba, S., Giambartolomei, G., Vella, I., Gronchi, F., Ruggieri, A., Marano, L., Fleres, F., Lovisetto, F., Barberis, A., Serra, D., Sasia, D., Geretto, P., Pellegrino, L., Borghi, B., Marano, A., Corino, C., Cannata, G., Giuffrida, M. C., Landra, F., Giraudo, G., Segalini, E., Monti, M., Magnoli, M., Pata, G., Lucchi, A., Grassia, M., Cufari, M. E., Sagnotta, A., Di Cintio, A., Gemini, A., Trastulli, S., De Luca, M., Desiderio, J., Gubbiotti, F., Campagnaro, T., Pedrazzani, C., Turri, G., Lazzarini, E., Conti, C., Ruzzenente, A., Petrelli, F., Marziali, I., Mazzocato, S., Vergari, R., Piazzai, F., Kubolli, I., Aggiusti, A., Paolucci, A., Ortenzi, M., Gallo, G., Clerico, G., De Santi, G., Bitonti, M. F., Trompetto, M., Realis Luc, A., Papandrea, M., Cerra, C., Pirillo, M., Cravano, S., Libri, I., Laquatra, N., Isabello, A., De Luca, E., Testa, V., Morino, M., Mistrangelo, M., Sinibaldi, G., Angelucci, G. P., Scaramuzzo, R., Larcinese, A., Fioriti, C., Picone, E., Nardi, M., Di Candido, F., Spinelli, A., Marco, M., Bevilacqua, M., Maroli, A., Colombo, F., Cigognini, M., Zaffaroni, G., Maffioli, A., Colombo, S., Bondurri, A., Sampietro, G., Foschi, D., Perrone, G., Bonati, E., Aresu, S., Saba, A., Biancafarina, A., Angelini, M., Andolfi, E., Miranda, E., Scricciolo, M., Provenza, G., Cavallina, G., Frezza, B., Fontani, A., Malatesti, R., Pellican??, G. A., Ceccarelli, G., Canonico, G., Falsetti, E., Pagnanelli, M., De Nardi, P., Rosati, R., Marcocci, G., Vignali, A., Quattromani, R., Curletti, G., Galleano, R., Malerba, M., Percivale, A., Ghazouani, O., Reggiani, L., Spirito, C., Bini, R., de Manzoni Garberini, A., Impellizzeri, H., Moretto, G., Bacchion, M., Casaril, A., Inama, M., Creciun, M., Vitali, M., Cillara, N., Mosino, L., Peddis, M., Melis, S., De Donno, G., Aru, A. C., Loche, G. A., Tutino, R., Licari, L., Campanella, S., Profita, G., Falco, N., Rotolo, G., Venturelli, P., De Marco, P., Marcian??, M., Picciariello, A., Chetta, N., Aquilino, F., Papagni, V., Coletta, D., Cerasari, S., Galiffa, G., Lapolla, P., Del Basso, C., Cirillo, B., De Toma, G., Fazzi, K., Bini, S., De Padua, C., Savino, G., Finotti, E., Ferrara, F., Stella, M., Gobatti, D., Tamini, N., Brenna, R., Giani, A., Tirotta, F., Famularo, S., Angrisani, M., Ceresoli, M., Talamo, G., Sucameli, F., Gennai, A., Moggia, E., Bianchi, C., Bonfante, P., Macina, S., Feleppa, C., Imperatore, M., Berti, S., Parini, D., Lanari, J., Giamundo, P., lo Conte, A., Pagano, G., Manigrasso, M., Danzi, M., Amato, R., Anastasio, L., Mastella, F., Basile, R., Peltrini, R., Marra, E., Luglio, G., Giglio, M., Anoldo, P., Vertaldi, S., Grimaldi, L., Tammaro, N., Ripetti, V., D'Alessio, R., Benvenuto, D., Pesce, A., Menduni, N., Giudicissi, R., Zalla, T., Baraghini, M., Romoli, L., Calussi, M., Vellei, S., Genzano, C., Feroci, F., Vita, M., Giani, I., Goldin, E., Ciccioli, E., Galgano, A., Zuin, M., Bettella, A., Barina, A., Vendramin, E., Palano, G., Schiavone, D., Rega, D., La Manna, V., Migliore, G., Aversano, A., Fares Bucci, A., Belli, A., Andriola, V., Lafranceschina, S., Gordini, L., Erdas, E., Podda, F., Cappellacci, F., Salaris, C., Sanna, S., Marcialis, J., Longheu, A., Foppa, C., Coratti, F., Montanelli, P., Grandi, S., Nelli, T., Ben Khaled, N., Cammelli, F., Ferrini, E., Billo, M. E., Piccolo, G., Romano, S., Gaetano, P., Pilotta, F., Baldassarre, L., Birindelli, A., D'Errico, U., Bianchini, S., Ferrari, C., Franceschi, A., Caristo, G., Ballarini, Z., Romelli, M., Ruggiero, S., Percassi, A., Milone, M., De Rosa, M., Pipitone Federico, N. S., Molteni, B., Magri Piccinini, A., Tilocca, P. L., Marrosu, A. G., Scognamillo, F., Pala, C., Attene, F., Carboni, L., Ruggiu, M. W., Gabbas, G., Sancini, G., Roggiani, A., Balsamo, F., Gori, A., Cuicchi, D., Vittori, L., Piozzi, G. N., Tringali, D., Bevilacqua, E., Panizzo, V., Lauretta, A., Poillucci, G., Mulas, S., Simcikas, D., Samalavicius, N. E., Nutautiene, V., Zeromskas, P., Jurgaitis, J., Aliosin, O., Slepavicius, A., Eismontas, V., Kybransiene, M., Portelli, L., Cachia, C., Cefai, C., Youssef, Y., Degaetano, D., Debono, S., Sammut, M., Cassar, J., Sammut, K., Andrejevic, P., van Wijnbergen, J. W. M., Dinger, T. L., ten Doesschate, S. F. H., van Dalen, A. S. H. M., Looijen, R. C., Becker, M. A. 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T., Dahya, D., Hardie Boys, M., Fleischl, W., Desmond, B., Tan, J., Skavysh, A., Castro, J., Orelhas, L., Santos, J., Pacheco, A., Rocha, A. F., Jervis, M. J., Pedro, V., Paix??o, V., Guerreiro, A., Melo, D., Laranjeira, A., Machado, A., Horta, V., Rocha-Melo, M., Patr??cio, J., Pereira, M., Lima, R., Cinza, A. M., Oliveira, J., Velez, C., Senhorinho, R., Catarino, S., Aveiro, D., Couto, M., Loureiro, A. R., Neves-Marques, C., Louro, T., Morgado, M., Ferreira, A. S., Alves, M., Oliveira, N., L??rias, R., Estalagem, I., Botelho, C., Alves-Vale, C., Correia, J. G., Jardim, J. A. M., Domingos, S. P., Bai??o, J. M., Rocha, B. S., Lopes, N. M. R. O., Jord??o, D. M., ngelo, M. D., Caro??o, T., Vieira, B. N., Silva, A. G., Galv??o, D., Mora, A., Bettencourt, R., Quintela, A. C., Alves, D., Dias, B., Costa, C., Gon??alves, J. P., Valente, P., Freire, L., Saraiva, R., Moreira, M., Peixoto, R., Serra, M. L., Santos, T. C., Lages, R. R., Pimentel, A., Martins, M., Maciel, J., B??rtolo, J., Fidalgo Antunes, C., Cabral, F., Brito Silva, F., Dias Matos, A., Santos, M., Cunha, R., Duarte, M., Sousa, M., Cunha, M., Neves, J., M??nica, I., Oliveira, S., Ribeiro, H., Ferreira, M., Guimar??es, N., Azevedo, J., Louro, H., Queiros, T., Castro, B., Fonseca, S., Carvalho, L., Torre, A. P., Amado, A., Leite, M., Romano, M., Gomes, J. R., Monteiro, R. G., Eir??, F., Borges, F., Sim??es, J., Botelho, P., Cismasiu, B., Romano, J., Monteiro, C., Silva, M., Claro, M., Almeida, P., Cruz, A., Vaz Pinto, G., Sousa, D., Costa Santos, D., Silva, A., Silva, F., Almeida, M. R., Parreira, R., Faustino, A., Medeiros, N., Castro, R., Soares, B., Resendes, M., Peyroteo, M., Canotilho, R., Correia, A. M., Martins, P. C., Machado, N. D., S??, T. C., Bernardes, F. M., Saraiva, P., Almeida, J., Mendes, M., Fernandes, V., Ribeiro, A., Soares, D., Capote, H., Fialho, G., Reia, M., Pratas, N., Costa, J., Morais, S., Miranda, P., Cunha, C., Sousa, X., Amado, F., Batista, A., Seabra, J., Praxedes, V., Monteiro, N., Martins, I., Lamas, M., Devesa, H., Miranda, J., Martins, S. F., Cavadas, D., Silva, R., Pina, S., Paix??o, I., Frade, S., Guerreiro, I., Tom??, M., Patrocinio, S., Costa, M., Rosete, M., Senaratne, R., Kakodkar, P., Balasubramanian, I., Hogan, A., Al-Salihi, A., Vyas, V., Vedadi, A., English, C., Mohammed, N., Dervan, L., Kang, S. J., Morrissey, E., Compton, M., Litvin, A., Romanova, E., Ponomarev, N., Savchenko, A., M??sz??rosov??, K., Zubowicz, M., Such??n, P. K., Gerstmeier, J., Brazitikou, E., Fytrou, E., Celik, M., Dubovsk??, M., Schmalenbeck, J., Sautter, S. C., Ceyran, H., Panyko, A., Jaich, R., Fitchat, N., De Lima, H., Withey, K., Piperidis, A., Toyi, Y., Nicolaides, A., Brooks, S., Jaffer, T., Sparke, A., Van Staden, N., Mcduling, C. R., Claassen, L., Van Vuuren, S., Marx, M., Kruger, C., Weyers, J., Lecler, J., Nshalati Salvation, M., Mathebula, S., Chauke, J., Mculu, W., Ngwenya, Z., Cardo, J. Garc??a., Mora-Guzm??n, I., Sancho Muriel, J., de Andres Olabarria, U., Casaval Cornejo, L., Vicente Rodr??guez, I., Jim??nez Escovar, F., Calvo Fern??ndez, M., Portugal Mart??nez, A., Badiola Bergara, I., Landaluce Olavarria, A., del Pozo Andr??s, E., Muriel, P., Mestres, N., Cuello, E., Merichal, M., Sierra, J. E., Escoll, J., Rufas, M., Pinillos, A. I., Ortega, J., Cerd??n, C., Jimenez Vi??as, C., Alconchel, F., Mart??nez D??az, J. M., Ruiz Manzanera, J. J., Navarro Barrios, ??., Rodr??guez Pedre??o, L., Moreno, P. Garc??a., G??mez, M. Garc??a., Rodrigues, K., Abrisqueta, J., Esteban Sinovas, O., Oro, C. Fair??n., L??pez Otero, M., Toimil, C. Samart??n., Primo ??lvarez, J. C., Rodriguez Fernandez, L., Paniagua Garcia Se??orans, M., Figueroa Jim??nez, S., Livianos Arias-Camis??n, P., Nieto Arranz, J. M., Mateos Sexmero, M. J., Diego Alonso, E., Gonz??lez Amor, L., Claramonte Bellmunt, O., Mart??nez Caballero, J., Rubio-P??rez, I., Ramos Martin, P., Mate Mate, P., Marcano Chavez, C., Rubio-Perez, I., Ayllon, H., Aguilar-Mart??nez, M. M., Arroyo, A., Segura-Sampedro, J. J., Jer??-McFarlane, S., Soldevila-Verdeguer, C., Pine??o-Flores, C., Ambrona-Zafra, D., Fern??ndez-Vega, L., Gil-Catal??n, A., Craus-Miguel, A., Pujol-Cano, N., Sena-Ruiz, F., Olmedo Moreno, C., Pastor Idoate, C., Negre Parra, D., Soriano Li??bana, M. M., Campo Betancourth, C. F., Sevila Mico, S., Est??vez Diz, A. M., Mart??n-Balbuena, R., Garc??a-Vico, A., Roman-Rando, A., S??nchez-G??lvez, M. ??., Bersabe-Alonso, I. M., Vadillo-Bohorquez, A., Bustamante Recuenco, C., Calzada, M. G., Recuenco, C. B., Martin, M. C., Licardie Bola??os, R. E., Garcia Orozco, J. J., Ferrusola Diaz, D. A., Garcia Jimenez, M. L., Castro Diez, L., Mosquera Fernandez, C., Fern??ndez, P., Platero Diago, J., Veras Lista, M., Rif?? Terricabras, S., Butler Sanz, L., Alberch Camprub??, E., Rico Ferr??ndez, M., Puig Lao, E., De Pablo Mir??, M., D??az Padillo, A., Padilla Zegarra, E. D., Franco, M., Martinez, A., Forero-Torres, A., Alonso-Poza, A., Dieguez, B., Losada, M., Gilsanz, C., Alberdi San Rom??n, I., Ramos Jim??nez, F. A., P??rez Ortega, A., Trujillo Barbadillo, A., Romero Pujana, E., Fernandez Illera, M. V., Salvador Ros??s, H., Delisau Puig, O., Castro, A., Codony Bassols, C., Fernandes, N., damez, J. Garc??a., Caula Freixa, C., G??mez Romeu, N., Merayo ??lvarez, M., Merayo Alvarez, M., Alonso Batanero, E., Canales, I. Cifri??n., Villarejo Campos, P., Alberca-Paramo, A., Alia Verdejo, T., Ca??ete-Manzanares, J., Molina-Florez, M., Hern??ndez, L. C. Garc??a., Orozco Nu??ez, S., Suarez-Sanchez, M., Martin-Fernandez, J., Estaire Gomez, M., Lopes Moreira, C. C., Gutierrez Rios, R. D., Eizaguirre Ubegun, M., Novo Sukia, I., Uribe Isado, M., Iba??ez Alda, M., Enriquez-Navascues, J. M., Uriol Peralta, P., Lima Pinto, F., N????ez O??Sullivan, S., Serrano Navidad, M., Vivas Angeles, P., Vives Figueras, R., Baena Sanfeliu, E., Campillo Alonso, B., Alberich Prats, M., Duran Arrocha, J., Cornell?? Garceso, N., Uribe Galeano, C., Collado-Roura, F., Ripoll??s-Melchor, J., Garcea, A., G??mez Facundo, H., Troncoso Pereira, P., Garcia, J. M., Gil, A., Giordano, H. E., P??rez Guarinos, C. V., Blaser, B., Imadalou, L., Piazza, G., Teixeira, H., Pittet, O., Gaspar, S., Gagliardi, B., Haller, M. L., Huot, A., Yurdaor, S. S., Alim, Y. E., Binbuga, M., K??rkl??, ??., Ceylan, C., Yilmaz, S., alar, S. N., Yildirim, N., Yavuz, G., Biyiklioglu, O., Kopac, O., Baykan, B., Abbasguliyev, H., Mutlu, V., Mahmoudi, Y., Dossa, S. A. A., Mizan, S. R., Demirtas, B., Cavus, T., Yuksek, A., Karabulut, K., Uyanik, A., Kargici, K., Banaz, T., Abdulrahman, S. M. F., Yesilsancak, M., Yanikoglu, E., Karabulut, A., Kuyumcu, O. F., Kutluk, F., Tunc, E., Ozmen, B. B., Kurtoglu, G. K., Sel, E. K., Isler, V. C., Yilmaz, B. S., Adiyaman, C., Kara, M., Demirkaya, H. C., Korkmaz, H. K., Pektas, A. M., Mutlu, D., Tiftik, E., Aksoy, A. B., Karag??z, E., Sabanci, R., T??mer, S. S., Sarig??l, L., Aksoy, B., Emiroglu, B., Mollavelioglu, B., Gereklioglu, D., Guler, M., Toprak, S., Afsar, H. B., Guler, S. E., Alizade, E., Aydin, T., Yalcinkaya, A., Erdem, M., Kayacan, S., Sahin, C., Uysal, M., Karakus, K., Altiner, S., Demirci, Z. S., Eren, E., Yavas, M., Dogan, H., Ozoglu, F., Mazlum, S. S., Yelkenci, C., Baran, T., Satilmisoglu, M., Sahin, A. Z., Kilin??, A., Isik, K., Kocer, M. D., G??ner, B., Islek, E. C., Tombul, H. B., Boztug, C. Y., Tinaz, A., Yilmaz, M., Karaman, Y., Akin, F. A., Dansuk, S., Bas??avus, M., Kaya, M., Kutlu, B., Akyol, C., Bilicen, G., Yarenci, E., Demiroglu, Y., Sunal, A., Cinar, E. N., Tipi, O. U., Benli, G. E., Tasdelen, I., Tura, A., Ucar, A., Ekci, B., Bilgili, A. C., Kiraz, I. N., Aksoy, H., Basak, A., Karip, B., Uslu, ??., Seker, M. C., Erten, V., Memis, U., Ko??ak, Z. B., Karapinar, Y. E., Fakirullahoglu, M., K??seoglu, E., Yeni, M., Uygur, F. A., Kaya, Y., zen, D., lmez, M., Altintas, E., Toklu, R., Sari??i??ek, T., Isik, A. E., Demirci, K., Suresh, G., Anbarasan, J., Rehman, S., Hu, E., Timms, S., Reynolds, W., Hotchkies, A., Misra, V., Finch, B. J., Philip Rajathasan, T., Jeddy, H., Kyaw, H. A., Wong, N., Bhahirathan, Y., Donaldson, C., Sequeira Campos, M., Armitage, M. N., Hussain, A. S., Hardy, B., Hassan Serry, M. Y., Herron, J., Thakrar, C., Rojoa, D., Yeap, B., Iqbal, Z., Rojoa, D. M., Cabaleiro Barciela, C., Ruddy, C. M., Lindwe, S., Qamar, Y., Chuita, S., James, A., Bugelli, M., Chechelnitskaya, Y., Bylinski, T., Findlay, J. M., Skan, O., Kind, C., Tupper, P., Van Rhee, C., Honeyman, S. I., Menon, G., Sloper, W., Burford, C., Coey, J., Akbari, K., Whitehead, T., Dimitriadis, S., Marshall, K., Flint, E. J., Can, B., Cesmeli, E., Kus, D., Kavar, R. C., Cevlik, A. D., Cengiz, U., Turk, E. G., Yilmaz, I., Yumurtaci, ??., Emin, A., Girit, ??. a. g. r. i., Yildirak, M. K., Senyigit, E., G??ldag, A., S??yleyici, B., Aytin, Y. E., Akay, F. E., Iskan, N. G., Mutlu, B., Sunay, A. O., Bell, T., Limnatitou, D., Gormley, S., Taleongpong, P., Patel, V., Macgregor, L., Amini, S., Turner, C., To, N., Laurence, N., Green, C., Frostick, R., Khera, R., Povey, M., Mahapatra, S., Bradbury, M., Osunronbi, T., Tam, L. Y. C., Khanan Kaabneh, A., Lawther, J., Fisher, P., Tribedi, T., Moosa, A., Ramdin, A., Mcgee, F., Flanagan, S., Tan, Q. J., Anwar, H., Clough, R., Chrisp, B., Cassels, J., Cross, G. W. V., Refalo, A., Hadley, R., Mctighe, A., Farrow, F., Brodie, A., Davis, G., Shah, D. R., Bowers, C., M. P. E., Ng, Wong, R. T. W., Maese, S., Tandon, R., Gray, M., Kumar, A., Ciurleo, C., Nyamali, I., Hiremath, S., Sinha, S., Chowdhary, M., Kirupananthan, P., Boh, Z. Y., Dass, S., Soma, A., Newton, A., Hill, M., Shafiq, Y., Brkljac, M., Martin, H., Mcclarty, C., Sanyal, S., Alsaif, A., Bhopal, S., Muneeb, F., Page, O., Zeb, E., Al-Azzawi, A., Mcintosh, J., Vucicevic, A., Hughes, M., Brooks, L., Fanibi, B., Dixon, M., Njoku, P., Morris, D., Jobson, J., Trussell, S., Chowdhury, H., Alawode, D. O. T., Udayachandran, V., Alsoof, D., Ekert, J., Joseph, N., Zulkefley, N., Hunt, G., Christodoulou, T., Wright, O., Soman, S., Jamal, M., Beqiri, S., Borgas, P., Pereira, F., Browne, S., Yiu, J., Dworkin, A., Mak, J., Patrawala, S., Milinkovic, N., Schofield, R., Chauhan, M., Hartley, L., Hind, J., Heybourne, A., Morgan, H., Wickstone, C., Panagiotou, D., O'Connell, E., Dean, K., Iqbal, R., Walsh, L., Yu, N., Rana, N., Massie, E., Foong, J., Lee, Y. J., Mijalkov, D., Wells, A., Bull, N., Ajmera, A., Warburton, T., Morgan, S., Mahmoud, A., Schachtel, M., Mikhail, B., Fomin, I., Mekaeil, B., Jun, H. J. S., Hengpoonthana, R., Childs, S., Ridgway, S., Blefari, N. D. A., Tam, H., Puchalski, N., Ngai, C., Mackenzie, J., Johnson, N., Holmes, M., Zuzek, R., Saluja, T., Gould, T., Goh, Y. K., Selvaraj, T., Horne, D., Borrow, J. L., Campbell, C., Cousins, G., Jackson, L., Maheepala, K., Zhao, S., Holden, E., Tutt, L., Thompson, B., Collins, H., Louie, F., Buckland, B., Smith, D., Chong, C., Chua, T. H., Nayak, C., Redmond, J., Tan, R. R., Gramlick, M., Teh, J. S., S. Y., Ng, Britten-Jones, P., Mohd Rosli, R., Pham, H. D. V., Harris, M., Salibasic, M., Pavlov, V., Paycheva, T., Lyulenina, E., Kolev, N., Boev, B., Nguen, D., Mitkov, Y., Mitkov, E., Vladova, P., Dimitrov, V., Gabarski, A., Feradova, H., Mladenov, T., P??s, M., Adel, A., Sotona, O., Barto??, M., Amjad, T., Mal??, O., Berec, S., Hanu??ov??, M., Hurn??, M., rhalmi, J., S??rensen, J. S., Chanut, F., Magnin, J., Sch??ning, L., CS Simon, S., Galata, C., Karampinis, I., Th??wel, T., Seckler, A. M., Kerem, C., Durdevic, S., Herrle, F., Artioli, E., Giaccari, S., Nevoso, V., Schimera, A., Marino, S., Resta, G., Ongaro, D., Baronio, G., Raimondo, S., Casiraghi, S., Salvadori, R., Armellini, A., Vulcano, I., Bertilone, E., Pintabona, G., Viscosi, F., Mazzeo, C., Olivieri, M., Belluco, C., Antona, A. D., Basso, S., Frattalone, M., Marino, F., Carbone, F., Incollingo, P., Romano, F. M., Anania, M., Pulighe, F., Cruccu, A., Murru, M. L., Massaiu, C., Balestra, F., Pazzona, M., De Nisco, C., Gusai, G. P., Giannella, A., Santangelo, M., Frangella, F., Magagnano, D., Liberatore, P., Rondelli, F., Castagnoli, G., Bartoli, A., Bellochi, R., Spaziani, A., Conti, D., Poponesi, V., Trippetti, M., Amicucci, S., Tazza, G., Procacci, P., Giovannini, F., Basile, E., Moschetta, G., Cosmi, F., Romeo, G., Gasparrini, M., Virgilio, E., Sparta, C., Mura, F. A., Barmina, M., Lorettu, A., Rettaroli, C., Mastino, G., Ruggiu, G. V., Mura, G. A., Perrone, B. A., De Angelis, M., Mereu, A., Adamo, V., Bianco, C., Ricciardiello, M., Campanaro, C., Panaccio, P., Esposito, L. M., Di Mola, F. F., D'Ascanio, F., Pietroletti, R., Di Marco, F., Amico, A., Schembari, E., Puglisi, S., Tuminello, F., Fig??, F., Caiazzo, A., Selvaggi, L., Capozzolo, A., Braccio, B., Tru??kovs, A., Bartnick, A., Malcevs, E., Machatschek, M. J., Alm, J., Lapsa, S., Delorme, M., Zeynalov, F., Larnovskis, J., Sauka, J., Bodrov, D., Gailumsis, R., Wiemann, A. M., M??ller, N. L., Jelovskis, I., Deksnis, D., Bauermeister Potts, O., Slimbajevs, T., Ancans, G., Dulskas, A., Kuliavas, J., Kavaliauskas, P., Kavaliauskaite, R., te Molder, L., Tromp, J., Matthee, E., Tissen, Y. M., Brinkhuis, E., de Vries, H. S., Hart, E. 't., Beckers, K., Bekker, Y., Kakar, S., van Smaalen, T. C., Veen, O. C., Dingemans, S. A., van den Brink, L. C., Vijgen, G. H. E. J., van de Voort, E. M. F., van der Pool, A., van Rest, K. L. C., Haak, T., Gordinou de Gouberville, M. C., Saleh, S., Mens, M. A., Hoeks, E. M., Nieuwenhuizen, S., Brandsma, A. M., van Praag, E. M., Westerduin, E., Smit, M. P. C. M., van der Lely, S. J., de Ruiter, A., Ribbers, T., Aarts, C. A. M., Tulek, M. S., de Jonge, J., Kocak, S., Alqethami, H. J., Constansia, R., van Elst, P. C., Tissink, M. W., Azzahhafi, J., Bofarid, S., Kip, M., Saleh, W., Franssen, S., Boon, C. L., Franssen, R. J. M., Romaen, I., Jense, M. T. F., D'Souza, J., Pascoe, R., Scott, A., Stark, E., Mulholland, K., Lau, W. K., Smith, B., Adams, S. I. B., Shah, N., Ling, E., Young, J., Hawkins, R., Jacobson, A., Macfater, H., Stanfield, B., Henderson, N., Chuang, A., Maskill, L., Ker, H., Mouldey, K., Hu, R., Matthews, C., Aitken, E., Walker, M., Winstanley, J., Miguel, I., Martins, J., Cunha, M. F., Melo, J., Veiga, D. 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E., Camarero, E., Mart??nez Ill??n, M., Aranda Garc??a, L., L??zaro Cardona, M., Montalvo Olmedo, C., Izquierdo Moreno, A., Cuenca Ram??rez, A., Margarida, A., Pando, B., Liquete Mar??n, L., P??rez Calle, M., Ramos Cordero, M. J., Sagredo Cuartango, A., S??nchez, E., Marcos Rodrigo, A., Fernandez, A., Curtis, C., Bosch, M., Triguero, D., Bosch Ram??rez, M., De La Llave Serralvo, A., S??nchez, M. J., Mart??n-Borreg??n, P., Quevedo, A., Mart??nez, J., Mar??n, J. M., Rodr??guez, P., Esteban Avenda??o, I., Jim??nez Relimpio, C., Lancho Lavilla, P., Blanco Bartolom??, I., G??mez Cano, I., Blasco Andr??s, C., Abad-Motos, A., Mar??nez-Hurtado, E., Salvachua-Fern??ndez, R., Muniesa, C., Avelino, L., Cholewa, H., Sancho-Muriel, J., Navasquillo, M., Nav??o, A., Abell??, D., De Jesus, M., Alvarez, E., Kefleyesus, A., Bugmann, A., Piotet, L. M., Meijers, L., Tonchev, P., Tamosiunas, A., Rottier, S. J., Negoi, I., Bernado, I. 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L., Castro Diez, L., Mosquera Fernandez, C., Fernández, P., Platero Diago, J., Veras Lista, M., Rifà Terricabras, S., Butler Sanz, L., Alberch Camprubí, E., Rico Ferrández, M., Puig Lao, E., De Pablo Miró, M., Díaz Padillo, A., Padilla Zegarra, E. D., Franco, M., Martinez, A., Forero-Torres, A., Alonso-Poza, A., Dieguez, B., Losada, M., Gilsanz, C., Alberdi San Román, I., Ramos Jiménez, F. A., Pérez Ortega, A., Trujillo Barbadillo, A., Romero Pujana, E., Fernandez Illera, M. V., Salvador Rosés, H., Delisau Puig, O., Castro, A., Codony Bassols, C., Fernandes, N., García Ádamez, J., Caula Freixa, C., Gómez Romeu, N., Merayo Álvarez, M., Merayo Alvarez, M., Alonso Batanero, E., Cifrián Canales, I., Villarejo Campos, P., Alberca-Paramo, A., Alia Verdejo, T., Cañete-Manzanares, J., Molina-Florez, M., García Hernández, L. C., Orozco Nuñez, S., Suarez-Sanchez, M., Martin-Fernandez, J., Estaire Gomez, M., Lopes Moreira, C. C., Gutierrez Rios, R. D., Eizaguirre Ubegun, M., Novo Sukia, I., Uribe Isado, M., Ibañez Alda, M., Enriquez-Navascues, J. M., Uriol Peralta, P., Lima Pinto, F., Núñez O´Sullivan, S., Serrano Navidad, M., Vivas Angeles, P., Vives Figueras, R., Baena Sanfeliu, E., Campillo Alonso, B., Alberich Prats, M., Duran Arrocha, J., Cornellà Garceso, N., Uribe Galeano, C., Collado-Roura, F., Ripollés-Melchor, J., Garcea, A., Gómez Facundo, H., Troncoso Pereira, P., Garcia, J. M., Gil, A., Giordano, H. E., V Pérez Guarinos, C., Blaser, B., Imadalou, L., Piazza, G., Teixeira, H., Pittet, O., Gaspar, S., Gagliardi, B., Haller, M. L., Huot, A., Yurdaor, S. S., Alim, Y. E., Binbuga, M., Kürklü, Ö., Ceylan, C., Yilmaz, S., Çalar, S. N., Yildirim, N., Yavuz, G., Biyiklioglu, O., Kopac, O., Baykan, B., Abbasguliyev, H., Mutlu, V., Mahmoudi, Y., Dossa, S. A. A., Mizan, S. R., Demirtas, B., Cavus, T., Yuksek, A., Karabulut, K., Uyanik, A., Kargici, K., Banaz, T., Abdulrahman, S. M. F., Yesilsancak, M., Yanikoglu, E., Karabulut, A., Kuyumcu, O. F., Kutluk, F., Tunc, E., Ozmen, B. B., Kurtoglu, G. K., Sel, E. K., Isler, V. C., Yilmaz, B. S., Adiyaman, C., Kara, M., Demirkaya, H. C., Korkmaz, H. K., Pektas, A. M., Mutlu, D., Tiftik, E., Aksoy, A. B., Karagöz, E., Sabanci, R., Tümer, S. S., Sarigül, L., Aksoy, B., Emiroglu, B., Mollavelioglu, B., Gereklioglu, D., Guler, M., Toprak, S., Afsar, H. B., Guler, S. E., Alizade, E., Aydin, T., Yalcinkaya, A., Erdem, M., Kayacan, S., Sahin, C., Uysal, M., Karakus, K., Altiner, S., Demirci, Z. S., Eren, E., Yavas, M., Dogan, H., Ozoglu, F., Mazlum, S. S., Yelkenci, C., Baran, T., Satilmisoglu, M., Sahin, A. Z., Kilinç, A., Isik, K., Kocer, M. D., Güner, B., Islek, E. C., Tombul, H. B., Boztug, C. Y., Tinaz, A., Yilmaz, M., Karaman, Y., Akin, F. A., Dansuk, S., Basçavus, M., Kaya, M., Kutlu, B., Akyol, C., Bilicen, G., Yarenci, E., Demiroglu, Y., Sunal, A., Cinar, E. N., Tipi, O. U., Benli, G. E., Tasdelen, I., Tura, A., Ucar, A., Ekci, B., Bilgili, A. C., Kiraz, I. N., Aksoy, H., Basak, A., Karip, B., Uslu, Ö., Seker, M. C., Erten, V., Memis, U., Koçak, Z. B., Karapinar, Y. E., Fakirullahoglu, M., Köseoglu, E., Yeni, M., Uygur, F. A., Kaya, Y., Özen, D., Ölmez, M., Altintas, E., Toklu, R., Sariçiçek, T., Isik, A. E., Demirci, K., Suresh, G., Anbarasan, J., Rehman, S., Hu, E., Timms, S., Reynolds, W., Hotchkies, A., Misra, V., Finch, B. J., Philip Rajathasan, T., Jeddy, H., Kyaw, H. A., Wong, N., Bhahirathan, Y., Donaldson, C., Sequeira Campos, M., Armitage, M. N., Hussain, A. S., Hardy, B., Hassan Serry, M. Y., Herron, J., Thakrar, C., Rojoa, D., Yeap, B., Iqbal, Z., Rojoa, D. M., Cabaleiro Barciela, C., Ruddy, C. M., Lindwe, S., Qamar, Y., Chuita, S., James, A., Bugelli, M., Chechelnitskaya, Y., Bylinski, T., Findlay, J. M., Skan, O., Kind, C., Tupper, P., Van Rhee, C., Honeyman, S. I., Menon, G., Sloper, W., Burford, C., Coey, J., Akbari, K., Whitehead, T., Dimitriadis, S., Marshall, K., Flint, E. J., Can, B., Cesmeli, E., Kus, D., Kavar, R. C., Cevlik, A. D., Cengiz, U., Turk, E. G., Yilmaz, I., Yumurtaci, Ö., Emin, A., Girit, Ç. a. g. r. i., Yildirak, M. K., Senyigit, E., Güldag, A., Söyleyici, B., Aytin, Y. E., Akay, F. E., Iskan, N. G., Mutlu, B., Sunay, A. O., Bell, T., Limnatitou, D., Gormley, S., Taleongpong, P., Patel, V., Macgregor, L., Amini, S., Turner, C., To, N., Laurence, N., Green, C., Frostick, R., Khera, R., Povey, M., Mahapatra, S., Bradbury, M., Osunronbi, T., Tam, L. Y. C., Khanan Kaabneh, A., Lawther, J., Fisher, P., Tribedi, T., Moosa, A., Ramdin, A., Mcgee, F., Flanagan, S., Tan, Q. J., Anwar, H., Clough, R., Chrisp, B., Cassels, J., Cross, G. W. V., Refalo, A., Hadley, R., Mctighe, A., Farrow, F., Brodie, A., Davis, G., Shah, D. R., Bowers, C., Ng, M. P. E., Wong, R. T. W., Maese, S., Tandon, R., Gray, M., Kumar, A., Ciurleo, C., Nyamali, I., Hiremath, S., Sinha, S., Chowdhary, M., Kirupananthan, P., Boh, Z. Y., Dass, S., Soma, A., Newton, A., Hill, M., Shafiq, Y., Brkljac, M., Martin, H., Mcclarty, C., Sanyal, S., Alsaif, A., Bhopal, S., Muneeb, F., Page, O., Zeb, E., Al-Azzawi, A., Mcintosh, J., Vucicevic, A., Hughes, M., Brooks, L., Fanibi, B., Dixon, M., Njoku, P., Morris, D., Jobson, J., Trussell, S., Chowdhury, H., Alawode, D. O. T., Udayachandran, V., Alsoof, D., Ekert, J., Joseph, N., Zulkefley, N., Hunt, G., Christodoulou, T., Wright, O., Soman, S., Jamal, M., Beqiri, S., Borgas, P., Pereira, F., Browne, S., Yiu, J., Dworkin, A., Mak, J., Patrawala, S., Milinkovic, N., Schofield, R., Chauhan, M., Hartley, L., Hind, J., Heybourne, A., Morgan, H., Wickstone, C., Panagiotou, D., O'Connell, E., Dean, K., Iqbal, R., Walsh, L., Yu, N., Rana, N., Massie, E., Foong, J., Lee, Y. J., Mijalkov, D., Wells, A., Bull, N., Ajmera, A., Warburton, T., Morgan, S., Mahmoud, A., Schachtel, M., Mikhail, B., Fomin, I., Mekaeil, B., Jun, H. J. S., Hengpoonthana, R., Childs, S., Ridgway, S., Blefari, N. D. A., Tam, H., Puchalski, N., Ngai, C., Mackenzie, J., Johnson, N., Holmes, M., Zuzek, R., Saluja, T., Gould, T., Goh, Y. K., Selvaraj, T., Horne, D., Borrow, J. L., Campbell, C., Cousins, G., Jackson, L., Maheepala, K., Zhao, S., Holden, E., Tutt, L., Thompson, B., Collins, H., Louie, F., Buckland, B., Smith, D., Chong, C., Chua, T. H., Nayak, C., Redmond, J., Tan, R. R., Gramlick, M., Teh, J. S., Ng, S. Y., Britten-Jones, P., Mohd Rosli, R., Pham, H. D. V., Harris, M., Salibasic, M., Pavlov, V., Paycheva, T., Lyulenina, E., Kolev, N., Boev, B., Nguen, D., Mitkov, Y., Mitkov, E., Vladova, P., Dimitrov, V., Gabarski, A., Feradova, H., Mladenov, T., Pös, M., Adel, A., Sotona, O., Bartoš, M., Amjad, T., Malý, O., Berec, S., Hanušová, M., Hurný, M., Örhalmi, J., Sørensen, J. S., Chanut, F., Magnin, J., Schöning, L., CS Simon, S., Galata, C., Karampinis, I., Thäwel, T., Seckler, A. M., Kerem, C., Durdevic, S., Herrle, F., Artioli, E., Giaccari, S., Nevoso, V., Schimera, A., Marino, S., Resta, G., Ongaro, D., Baronio, G., Raimondo, S., Casiraghi, S., Salvadori, R., Armellini, A., Vulcano, I., Bertilone, E., Pintabona, G., Viscosi, F., Mazzeo, C., Olivieri, M., Belluco, C., Antona, A. D., Basso, S., Frattalone, M., Marino, F., Carbone, F., Incollingo, P., Romano, F. M., Anania, M., Pulighe, F., Cruccu, A., Murru, M. L., Massaiu, C., Balestra, F., Pazzona, M., De Nisco, C., Gusai, G. P., Giannella, A., Santangelo, M., Frangella, F., Magagnano, D., Liberatore, P., Rondelli, F., Castagnoli, G., Bartoli, A., Bellochi, R., Spaziani, A., Conti, D., Poponesi, V., Trippetti, M., Amicucci, S., Tazza, G., Procacci, P., Giovannini, F., Basile, E., Moschetta, G., Cosmi, F., Romeo, G., Gasparrini, M., Virgilio, E., Sparta, C., Mura, F. A., Barmina, M., Lorettu, A., Rettaroli, C., Mastino, G., Ruggiu, G. V., Mura, G. A., Perrone, B. A., De Angelis, M., Mereu, A., Adamo, V., Bianco, C., Ricciardiello, M., Campanaro, C., Panaccio, P., Esposito, L. M., Di Mola, F. F., D'Ascanio, F., Pietroletti, R., Di Marco, F., Amico, A., Schembari, E., Puglisi, S., Tuminello, F., Figà, F., Caiazzo, A., Selvaggi, L., Capozzolo, A., Braccio, B., Truškovs, A., Bartnick, A., Malcevs, E., Machatschek, M. J., Alm, J., Lapsa, S., Delorme, M., Zeynalov, F., Larnovskis, J., Sauka, J., Bodrov, D., Gailumsis, R., Wiemann, A. M., Müller, N. L., Jelovskis, I., Deksnis, D., Bauermeister Potts, O., Slimbajevs, T., Ancans, G., Dulskas, A., Kuliavas, J., Kavaliauskas, P., Kavaliauskaite, R., te Molder, L., Tromp, J., Matthee, E., Tissen, Y. M., Brinkhuis, E., de Vries, H. S., 't Hart, E., Beckers, K., Bekker, Y., Kakar, S., van Smaalen, T. C., Veen, O. C., Dingemans, S. A., van den Brink, L. C., Vijgen, G. H. E. J., van de Voort, E. M. F., van der Pool, A., van Rest, K. L. C., Haak, T., Gordinou de Gouberville, M. C., Saleh, S., Mens, M. A., Hoeks, E. M., Nieuwenhuizen, S., Brandsma, A. M., van Praag, E. M., Westerduin, E., Smit, M. P. C. M., van der Lely, S. J., de Ruiter, A., Ribbers, T., Aarts, C. A. M., Tulek, M. S., de Jonge, J., Kocak, S., Alqethami, H. J., Constansia, R., van Elst, P. C., Tissink, M. W., Azzahhafi, J., Bofarid, S., Kip, M., Saleh, W., Franssen, S., Boon, C. L., Franssen, R. J. M., Romaen, I., Jense, M. T. F., D'Souza, J., Pascoe, R., Scott, A., Stark, E., Mulholland, K., Lau, W. K., Smith, B., Adams, S. I. B., Shah, N., Ling, E., Young, J., Hawkins, R., Jacobson, A., Macfater, H., Stanfield, B., Henderson, N., Chuang, A., Maskill, L., Ker, H., Mouldey, K., Hu, R., Matthews, C., Aitken, E., Walker, M., Winstanley, J., Miguel, I., Martins, J., Cunha, M. F., Melo, J., Veiga, D. N., Rachadell, J., Amorim, E., Vareda, R., Roseira, J., Americano, M., Correia, D., Capella, V., Moinhos, T., Costa, F., Gil, I., Morgado, J., Varghese, S., Boyle, E., Aljohmani, L., Alexander, J., Graziadei, V., Mccaughey, C., Jain, A., O'Connor, D. B., Ramanayake, H., Sabnani, R., Colon, L. F., Bansal, N., Stephens, I., Tan, R., Hoo, M., Doherty, G., Fenn, S., Mulhare, E., Walsh, M., Leavey, C., Costigan, O., Griffin, S., Dockry, É., Khogali, E., Aly, A. K., Mcphedran, R., O'Gorman, D., Vermeulen, D., Gopaul, A., Pentony, A. R., Piong, C. L., Nossier, R., Hanna, J., Sabir, K., Eow, S. Y., Ladak, N., Boersma, D., Kamath, P. J., Soh, T. B. W., Dyer, A. H., Chee, S. Y., Tan, I. X. H., Kelliher, A., Scanlon, K., Adeusi, L., Howarth, N., Mccawley, N., O'Neill, A., Jones, M. R., Saleh, R., Singh, A., O'Dwyer, N., Mana, O. C., Gomez, H., Riba, L., Perez, J., Centeno, A., Ortega, C., Ossola, M. E., Camarero, E., Martínez Illán, M., Aranda García, L., Lázaro Cardona, M., Montalvo Olmedo, C., Izquierdo Moreno, A., Cuenca Ramírez, A., Margarida, A., Pando, B., Liquete Marín, L., Pérez Calle, M., Ramos Cordero, M. J., Sagredo Cuartango, A., Sánchez, E., Marcos Rodrigo, A., Fernandez, A., Curtis, C., Bosch, M., Triguero, D., Bosch Ramírez, M., De La Llave Serralvo, A., Sánchez, M. J., Martín-Borregón, P., Quevedo, A., Martínez, J., Marín, J. M., Rodríguez, P., Esteban Avendaño, I., Jiménez Relimpio, C., Lancho Lavilla, P., Blanco Bartolomé, I., Gómez Cano, I., Blasco Andrés, C., Abad-Motos, A., Marínez-Hurtado, E., Salvachua-Fernández, R., Muniesa, C., Avelino, L., Cholewa, H., Sancho-Muriel, J., Navasquillo, M., Navío, A., Abelló, D., De Jesus, M., Alvarez, E., Kefleyesus, A., Bugmann, A., Piotet, L. M., Meijers, L., Tonchev, P., Tamosiunas, A., Rottier, S. J., Negoi, I., Bernado, I. R., Eftychiou, S., RS: NUTRIM - R2 - Liver and digestive health, MUMC+: MA Mondzorg Kaak Aangezicht Chirurgie (9), Kindergeneeskunde, RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health, and Faculteit Medische Wetenschappen/UMCG
Subjects: renal failure, cohort studies, humans, kidney, postoperative complications, prognosis, prospective studies, retrospective studies, risk assessment, risk factors, acute kidney injury, digestive system surgical procedures, Prognosi, Acute Kidney Injury/diagnosis, Digestive System Surgical Procedures/adverse effects, 3121 Internal medicine, Kidney, Risk Assessment, Cohort Studies, Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14], All institutes and research themes of the Radboud University Medical Center, Postoperative Complications, Retrospective Studie, Risk Factors, Gastrointestinal Surgery, Humans, preoperative care, Prognostic Model, Prospective Studies, Digestive System Surgical Procedures, Retrospective Studies, Science & Technology, Risk Factor, MORTALITY, General Medicine, STARSurg Collaborative and EuroSurg Collaborative, Acute Kidney Injury, Prognosis, surgical procedures, Prospective Studie, aki, OAKS, Postoperative Complications/etiology, colorectal surgery, Surgery, Postoperative Complication, Cohort Studie, Life Sciences & Biomedicine, Human
Abstract: Background Postoperative acute kidney injury (AKI) is a common complication of major gastrointestinal surgery with an impact on short- and long-term survival. No validated system for risk stratification exists for this patient group. This study aimed to validate externally a prognostic model for AKI after major gastrointestinal surgery in two multicentre cohort studies. Methods The Outcomes After Kidney injury in Surgery (OAKS) prognostic model was developed to predict risk of AKI in the 7 days after surgery using six routine datapoints (age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker). Validation was performed within two independent cohorts: a prospective multicentre, international study (‘IMAGINE’) of patients undergoing elective colorectal surgery (2018); and a retrospective regional cohort study (‘Tayside’) in major abdominal surgery (2011–2015). Multivariable logistic regression was used to predict risk of AKI, with multiple imputation used to account for data missing at random. Prognostic accuracy was assessed for patients at high risk (greater than 20 per cent) of postoperative AKI. Results In the validation cohorts, 12.9 per cent of patients (661 of 5106) in IMAGINE and 14.7 per cent (106 of 719 patients) in Tayside developed 7-day postoperative AKI. Using the OAKS model, 558 patients (9.6 per cent) were classified as high risk. Less than 10 per cent of patients classified as low-risk developed AKI in either cohort (negative predictive value greater than 0.9). Upon external validation, the OAKS model retained an area under the receiver operating characteristic (AUC) curve of range 0.655–0.681 (Tayside 95 per cent c.i. 0.596 to 0.714; IMAGINE 95 per cent c.i. 0.659 to 0.703), sensitivity values range 0.323–0.352 (IMAGINE 95 per cent c.i. 0.281 to 0.368; Tayside 95 per cent c.i. 0.253 to 0.461), and specificity range 0.881–0.890 (Tayside 95 per cent c.i. 0.853 to 0.905; IMAGINE 95 per cent c.i. 0.881 to 0.899). Conclusion The OAKS prognostic model can identify patients who are not at high risk of postoperative AKI after gastrointestinal surgery with high specificity. Presented to Association of Surgeons in Training (ASiT) International Conference 2018 (Edinburgh, UK), European Society of Coloproctology (ESCP) International Conference 2018 (Nice, France), SARS (Society of Academic and Research Surgery) 2020 (Virtual, UK).
Published: 2022

29. Memetising the pandemic: memes, covid-19 mundanity and political cultures

Author: Maria Francesca Murru and Stefania Vicari
Published: 2023

30. Association of low-density neutrophils with lung function and disease progression in adult cystic fibrosis

Author: Murru Andréa, Vadeboncoeur Nathalie, Therrien Andrée-Anne, Coderre Lise, Vaillancourt Myriam, Labrecque Marie-Michèle, Berthiaume Yves, Bouvet Guillaume, Adam Damien, Brochiero Emmanuelle, Lesage Sylvie, Flamand Nicolas, Bilodeau Lara, and Maria J. Fernandes
Subjects: Pulmonary and Respiratory Medicine, Pediatrics, Perinatology and Child Health
Published: 2023

31. Temporal Variations of Seismicity Rates and Gutenberg–Richterb-Values for a Stochastic Declustered Catalog: An Example in Central Italy

Author: Anna Eliana Pastoressa, Maura Murru, Matteo Taroni, Rodolfo Console, Caterina Montuori, Giuseppe Falcone, and Raffaele Di Stefano
Subjects: Geophysics
Abstract: One important aspect of the seismicity is the spatiotemporal clustering; hence, the distinction between independent and triggered events is a critical part of the analysis of seismic catalogs. Stochastic declustering of seismicity allows a probabilistic distinction between these two kinds of events. Such an approach, usually performed with the epidemic-type aftershock sequence (ETAS) model, avoids the bias in the estimation of the frequency–magnitude distribution parameters if we consider a subset of the catalog, that is, only the independent or the triggered events. In this article, we present a framework to properly include the probabilities of any event to be independent (or triggered) both in the temporal variation of the seismic rates and in the estimation of the b-value of the Gutenberg–Richter law. This framework is then applied to a high-definition seismic catalog in the central part of Italy covering the period from April 2010 to December 2015. The results of our analysis show that the seismic activity from the beginning of the catalog to March 2013 is characterized by a low degree of clustering and a relatively high b-value, whereas the following period exhibits a higher degree of clustering and a smaller b-value.
Published: 2023

32. New Horizons in Metastatic Colorectal Cancer: Prognostic Role of CD44 Expression

Author: Pina Ziranu, Valentina Aimola, Andrea Pretta, Marco Dubois, Raffaele Murru, Nicole Liscia, Flaviana Cau, Mara Persano, Giulia Deias, Enrico Palmas, Francesco Loi, Marco Migliari, Valeria Pusceddu, Marco Puzzoni, Eleonora Lai, Stefano Cascinu, Gavino Faa, and Mario Scartozzi
Subjects: cancer stem cells, Cancer Research, Oncology, metastatic colorectal cancer, CD44 expression, biomarkers
Abstract: Background: The transmembrane glycoprotein CD44, the major hyaluronan (HA) receptor, has been proven to regulate cell growth, survival, differentiation, and migration. It is therefore widely considered to be involved in carcinogenesis. Its role as a new therapeutic target in solid tumors is under evaluation in clinical trials. The prognostic value remains controversial. Here, we aimed to investigate the correlation between CD44 expression and the clinicopathological features and survival in metastatic colorectal cancer (mCRC) patients. Methods: Data from 65 mCRC patients of the Medical Oncology Unit, University Hospital and University of Cagliari were retrospectively collected from 2008 to 2021. Immunohistochemical analysis was performed at the Pathology Division, University Hospital of Cagliari on 3 μm thick sections obtained from paraffin blocks. The intensity of immunohistochemical staining was subclassified into four groups: score 0 if negative or weak membrane staining in less than 10% of tumor cells; score 1+ if weak membrane staining in at least 10% of tumor cells or moderate membrane staining in less than 10% of tumor cells; score 2+ if moderate membrane staining in at least 10% of tumor cells or intensive membrane staining in less than 10% of tumor cells; score 3+ if intense membrane staining in at least 10% of tumor cells. Based on this score, we distinguished patients into low CD44 expression (score 0, 1+, 2+) and high CD44 expression (score 3+). Statistical analysis was performed with MedCalc (survival distribution: Kaplan–Meier; survival comparison: log-rank test; association between categorical variables: Fisher’s exact test). Results: Patients’ median age was 66 years (range 49–85). Regarding CD44 expression, score was 0 in 18 patients, 1+ in 15 patients, 2+ in 18 patients, and 3+ in 14 patients. Median overall survival (mOS) was 28.1 months (95%CI: 21.3–101). CD44 overexpression (3+) was correlated with poor prognosis (p = 0.0011; HR = 0.2), with a mOS of 14.5 months (95%CI 11.7 to 35.9) versus 30.7 months (95%CI 27.8 to 101) in lower CD44 expression. Higher CD44 expression was associated with clinically poor prognostic features: age ≥ 70 years (p = 0.0166); inoperable disease (p = 0.0008); stage IV at diagnosis (p = 0.0241); BRAF mutated (p = 0.0111), high-grade tumor (p = 0.0084). Conclusions: CD44 markedly correlated with aggressive tumor behavior and contributed to the earlier progression of disease, thus suggesting its role as a novel prognostic marker and potential therapeutic target for mCRC patients.
Published: 2023
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33. Heights and transcendence of $p$--adic continued fractions

Author: Longhi, Ignazio, Murru, Nadir, and Saettone, Francesco Maria
Subjects: Mathematics - Number Theory, FOS: Mathematics, Number Theory (math.NT), 11J70, 11J87
Abstract: Special kinds of continued fractions have been proved to converge to transcendental real numbers by means of the celebrated Subspace Theorem. In this paper we study the analogous $p$--adic problem. More specifically, we deal with Browkin $p$--adic continued fractions. First we give some new remarks about the Browkin algorithm in terms of a $p$--adic Euclidean algorithm. Then, we focus on the heights of some $p$--adic numbers having a periodic $p$--adic continued fraction expansion and we obtain some upper bounds. Finally, we exploit these results, together with $p$--adic Roth-like results, in order to prove the transcendence of two families of $p$--adic continued fractions., 13 pages, correction of a mistake in the previous version
Published: 2023

34. Form as a Driver for Regeneration: A Methodological Approach to Rethinking School Building Infrastructure in Italy

Author: Caterina Barioglio, Daniele Campobenedetto, Lorenzo Murru, and Caterina Quaglio
Subjects: Équipement scolaire, Régénération urbaine, Spatial Learning, Typologie, Educational Community, Educational Spaces, Spatial Agency, Typology, Urban Regeneration, Transformation Potential, Espaces éducatifs, Agentivité spatiale, Potentiel de transformation, Espace urbain, Environnement scolaire, School Architecture, Schools, École, General Medicine, Contrat École, Architecture d’école, Écosystème école, Trajets quotidiens, Communauté éducative, Apprentissages spatiaux, Campus, Architecture education, territorial experiments
Abstract: Italian school infrastructure is a multi-layered and diversified spatial asset which requires systemic rethinking in order to respond to evolving educational, energy and health needs. This has become evident not only as a consequence of the Covid-19 emergency, but also due to demographic and educational changes that have taken place over the years. The objective of the present work is to outline a methodological approach aimed at promoting agency within local communities and defining regeneration priorities and strategies through the co-construction of shared spatial knowledge. In a context in which tools and funds for a substantial renovation of the Italian public infrastructure are and will be available, the article explores the theoretical framework that enabled the implementation of a specific design tool — a web application — as a replicable operative model for school regeneration and describes how its prototype was built. More precisely, the web app is aimed at supporting and empowering the actors entrusted with governing the transformation of schools by identifying spatial resources and potentials. To this end, typological classification based on the current spatial characteristics of the buildings is assumed as a way to highlight the transformation potential of schools and to outline intervention priorities at a regional level. Drawing on the concept of spatial agency, the physical space of schools is therefore conceived as a shared documentary basis for the development of multi-scalar governance systems. L’infrastructure scolaire italienne constitue un patrimoine spatial stratifié et diversifié, qui nécessite une révision systémique pour répondre à l’évolution des besoins éducatifs, énergétiques et sanitaires mis en évidence non seulement par l’urgence pandémique mais aussi par les changements démographiques et pédagogiques des dernières années. L’objectif de cet article est de définir une approche méthodologique visant à favoriser la capacité d’agir des collectivités locales et à définir des priorités et des stratégies de régénération par la co-construction de connaissances spatiales partagées. Dans un contexte politique et financier qui offre l’occasion pour une restructuration substantielle de l’infrastructure publique italienne, le texte explore le cadre théorique qui a permis la mise en œuvre d’un outil de conception - une application web - comme modèle opérationnel reproductible pour la régénération des écoles et décrit la réalisation de son prototype. Plus précisément, l’application web développée dans le cadre de la recherche vise à soutenir et à habiliter les acteurs chargés de la transformation des espaces scolaires par l’identification des ressources et potentiels spatiaux. À cette fin, un système de classification typologique basé sur les caractéristiques spatiales actuelles des bâtiments est utilisé comme un moyen pour mettre en évidence le potentiel de transformation des écoles et pour définir des priorités d’intervention à l’échelle régionale. À partir du concept d’« agentivité spatiale », l’espace physique des écoles est donc conçu comme une base documentaire partagée pour le développement de systèmes de gouvernance multi-scalaires.
Published: 2023

35. High rate of durable responses with undetectable minimal residual disease with frontline venetoclax and rituximab in young and fit patients with chronic lymphocytic leukemia and an adverse biologic profile: results of the GIMEMA phase II LLC1518 - 'Veritas' study

Author: Francesca R Mauro, Irene Della Starza, Monica Messina, Gianluigi Reda, Livio Trentin, Marta Coscia, Paolo Sportoletti, Lorella Orsucci, Valentina Arena, Gloria Margiotta Casaluci, Roberto Marasca, Roberta Murru, Luca Laurenti, Fiorella Ilariucci, Caterina Stelitano, Donato Mannina, Massimo Massaia, Gian Matteo Rigolin, Lydia Scarfò, Monia Marchetti, Luciano Levato, Monica Tani, Annalisa Arcari, Gerardo Musuraca, Marina Deodato, Piero Galieni, Valeria Belsito Patrizi, Daniela Gottardi, Anna Marina Liberati, Annamaria Giordano, Maria Chiara Molinari, Daniela Pietrasanta, Veronica Mattiello, Andrea Visentin, Candida Vitale, Francesco Albano, Antonino Neri, Lucia Anna De Novi, Maria Stefania De Propris, Mauro Nanni, Ilaria Del Giudice, Anna Guarini, Paola Fazi, Marco Vignetti, Alfonso Piciocchi, Antonio Cuneo, and Robin Foà
Subjects: Venetoclax, Settore MED/15 - MALATTIE DEL SANGUE, chronic lymphocytic leukemia, Hematology, Rituximab
Abstract: The GIMEMA phase II LLC1518 VERITAS trial investigated the efficacy and safety of frontline, fixed-duration venetoclax and rituximab (VenR) combination in young (≤65 years) and fit patients with chronic lymphocytic leukemia (CLL) and unmutated IGHV and/or TP53 disruption. Treatment consisted of the Ven ramp-up, six-monthly courses of the VenR combination, followed by six monthly courses of Ven single agent. A centralized assessment of measurable minimal residual disease (MRD) was performed on the peripheral blood (PB) and bone marrow (BM) by ASO-PCR at the end of treatment (EOT) and during the follow-up. The primary endpoint was the complete remission (CR) rate at the EOT. Seventy-five patients were enrolled; the median age was 54 years (range 38-65), 96% had unmutated IGHV, 9 (12%) had TP53 disruption, and 4% were IGHV mutated with TP53 disruption. The overall response rate (ORR) at the EOT was 94.7%, with a CR rate of 76%. An undetectable (u) MRD was recorded in 69.3% of patients in the PB and 58.7% in the BM. The 12-month MRD-free survival in the 52 patients with uMRD in the PB at the EOT was 73.1%. After a median follow-up of 20.8 months, no disease progressions were observed. Three patients have died, two due to Covid-19 and 1 to tumor lysis syndrome. The first report of the VERITAS study shows that frontline VenR was associated with a high rate of CRs and durable responses with uMRD in young patients with CLL and unfavorable genetic characteristics.
Published: 2023

36. La ripetizione nella Commedia: alcuni casi studio dal Vocabolario Dantesco

Author: Felicani, E. and Murru, C.
Subjects: Settore L-FIL-LET/12 - Linguistica Italiana
Published: 2023

37. Obliterated cavum septi pellucidi: Clinical significance and role of fetal magnetic resonance

Author: Fantasia, I., Ciardo, C., Bracalente, G., Filippi, E., Murru, F. M., Spezzacatene, A., Bin, M., Mendez&nbsp, Quintero, O., Montaguti, E., Lees, C., Papanikolaou, K., Pilu, G., Prefumo, F., Thilaganathan, B., and Stampalija, T.
Subjects: cavum septi pellucidi, fetal brain, Obstetrics and Gynecology, fetal magnetic resonance, neurosonography, postnatal neurodevelopmental outcome, General Medicine
Published: 2023

38. Neuronal network activity and connectivity are impaired in a conditional knockout mouse model with PCDH19 mosaic expression

Author: Giorgia Giansante, Sara Mazzoleni, Antonio G. Zippo, Luisa Ponzoni, Anna Ghilardi, Greta Maiellano, Elly Lewerissa, Eline van Hugte, Nael Nadif Kasri, Maura Francolini, Mariaelvina Sala, Luca Murru, Silvia Bassani, and Maria Passafaro
Subjects: Cellular and Molecular Neuroscience, Psychiatry and Mental health, Settore BIO/13 - Biologia Applicata, Molecular Biology
Abstract: Mutations in PCDH19 gene, which encodes protocadherin-19 (PCDH19), cause Developmental and Epileptic Encephalopathy 9 (DEE9). Heterogeneous loss of PCDH19 expression in neurons is considered a key determinant of the disorder; however, how PCDH19 mosaic expression affects neuronal network activity and circuits is largely unclear. Here, we show that the hippocampus of Pcdh19 mosaic mice is characterized by structural and functional synaptic defects and by the presence of PCDH19-negative hyperexcitable neurons. Furthermore, global reduction of network firing rate and increased neuronal synchronization have been observed in different limbic system areas. Finally, network activity analysis in freely behaving mice revealed a decrease in excitatory/inhibitory ratio and functional hyperconnectivity within the limbic system of Pcdh19 mosaic mice. Altogether, these results indicate that altered PCDH19 expression profoundly affects circuit wiring and functioning, and provide new key to interpret DEE9 pathogenesis.
Published: 2023

39. Efficacy of front-line ibrutinib versus fludarabine, cyclophosphamide, and rituximab in patients with chronic lymphocytic leukemia: A retrospective multicenter 'Real-World' study

Author: Shai Levi, Yotam Bronstein, Neta Goldschmidt, Fortunato Morabito, Tomer Ziv‐Baran, Giovanni Del Poeta, Osnat Bairey, Maria Ilaria Del Principe, Riva Fineman, Francesca Romana Mauro, Odit Gutwein, Gianluigi Reda, Rosa Ruchlemer, Paolo Sportoletti, Luca Laurenti, Lev Shvidel, Marta Coscia, Tamar Tadmor, Marzia Varettoni, Ariel Aviv, Roberta Murru, Andrei Braester, Annalisa Chiarenza, Andrea Visentin, Daniela Pietrasanta, Giacomo Loseto, Antonella Zucchetto, Riccardo Bomben, Jacopo Olivieri, Antonio Neri, Davide Rossi, Gianluca Gaidano, Livio Trentin, Robin Foà, Antonio Cuneo, Chava Perry, Valter Gattei, Massimo Gentile, and Yair Herishanu
Subjects: Settore MED/15 - MALATTIE DEL SANGUE, Ibrutinib, Hematology
Published: 2023

40. Fisiologia del doppio

Author: Murru, Claudia
Subjects: Fantastique, Clinique, Scapigliatura, Igino Ugo Tarchetti, Membre fantôme
Abstract: Consacré au récit long Storia di una gamba (1868), ce chapitre y examine la reprise dans une veine fantastique de dispositifs des savoirs médicaux du temps, à commencer par celui de l’observation clinique. À partir d’une reconstruction des éléments pathologiques du récit, il s’agit d’explorer une rêverie sur le corps toute centrée sur le principe de la preuve clinique, en accordant une attention particulière aux effets narratifs que la rencontre entre fait pathologique et drame sentimental., Il contributo indaga il riuso in chiave fantastica di dispositivi del sapere medico, tra cui quello dominante dell’osservazione clinica, nel racconto lungo Storia di una gamba (1868). A partire da una indagine sugli elementi patologici del racconto, si esplorano i modi in cui viene messa in scena una fantasticheria sul corpo tutta incentrata sull’evidenza clinica, con particolare attenzione agli effetti narrativi della coincidenza tra fatto patologico e dramma sentimentale.
Published: 2023
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41. Continuous venetoclax in treatment-naive TP53 disrupted patients with chronic lymphocytic leukemia: A chronic lymphocytic leukemia campus study

Author: Visentin, Andrea, Mauro, Francesca Romana, Scarfò, Lydia, Gentile, Massimo, Farina, Lucia, Reda, Gianluigi, Ferrarini, Isacco, Proietti, Giulia, Derenzini, Enrico, Cibien, Francesca, Vitale, Candida, Sanna, Alessandro, Pietrasanta, Daniela, Marchetti, Monia, Murru, Roberta, Rigolin, Gian Matteo, Sportoletti, Paolo, Trimarco, Valentina, Cavarretta, Chiara Adele, Angotzi, Francesco, Cellini, Alessandro, Ruocco, Valeria, Zatta, Ivan, Laurenti, Luca, Molica, Stefano, Coscia, Marta, Ghia, Paolo, Foà, Robin, Cuneo, Antonio, and Trentin, Livio
Published: 2023

42. Giant non‐parasitic mixed splenic cyst in a child

Author: Mirco Cleva, Anna Vaivoda, Alessandro Boscarelli, Daniela Codrich, Anita Spezzacatene, and Flora M Murru
Subjects: Pediatrics, Perinatology and Child Health
Published: 2022

43. A review and meta-analysis of gene expression profiles in suicide

Author: Ignazio S Piras, Matthew J. Huentelman, Federica Pinna, Pasquale Paribello, Marco Solmi, Andrea Murru, Bernardo Carpiniello, Mirko Manchia, and Clement C Zai
Subjects: Pharmacology, Brain, Prefrontal Cortex, DNA-Binding Proteins, Suicide, Psychiatry and Mental health, Neurology, Humans, Pharmacology (medical), Autopsy, Neurology (clinical), Transcriptome, Biological Psychiatry, Transcription Factors
Abstract: Suicide claims over 800,000 deaths worldwide, making it a serious public health problem. The etiopathophysiology of suicide remains unclear and is highly complex, and postmortem gene expression studies can offer insights into the molecular biological mechanism underlying suicide. In the current study, we conducted a meta-analysis of postmortem brain gene expression in relation to suicide. We identified five gene expression datasets for postmortem orbitofrontal, prefrontal, or dorsolateral prefrontal cortical brain regions from the Gene Expression Omnibus repository. After quality control, the total sample size was 380 (141 suicide deaths and 239 deaths from other causes). We performed the analyses using two meta-analytic approaches. We further performed pathway and cell-set enrichment analyses. We found reduced expression of the KCNJ2 (Potassium Inwardly Rectifying Channel Subfamily J Member 2), A2M (Alpha-2-Macroglobulin), AGT (Angiotensinogen), PMP2 (Peripheral Myelin Protein 2), and VEZF1 (Vascular Endothelial Zinc Finger 1) genes (FDR p0.05). Our findings support the involvement of astrocytes, stress response, immune system, and microglia in suicide. These findings will require further validation in additional large datasets.
Published: 2022

44. Preexisting and treatment-emergent autoimmune cytopenias in patients with CLL treated with targeted drugs

Author: Robin Foà, Lorenzo De Paoli, Giulia Zamprogna, Alessandra Tedeschi, Gian Matteo Rigolin, Valentina Griggio, Marika Porrazzo, Francesca Romana Mauro, Francesco Vassallo, Elsa Pennese, Massimo Gentile, Monia Marchetti, Lorella Orsucci, Lydia Scarfò, Ramona Cassin, Livio Trentin, Maria Chiara Montalbano, Roberta Murru, Antonio Cuneo, Francesca Perutelli, Elia Boccellato, Luca Laurenti, Gianluigi Reda, Paolo Rivela, Gianluca Gaidano, Luana Schiattone, Candida Vitale, Mario Boccadoro, Chiara Salvetti, Andrea Visentin, Marta Coscia, Vitale, C., Salvetti, C., Griggio, V., Porrazzo, M., Schiattone, L., Zamprogna, G., Visentin, A., Vassallo, F., Cassin, R., Rigolin, G. M., Murru, R., Laurenti, L., Rivela, P., Marchetti, M., Pennese, E., Gentile, M., Boccellato, E., Perutelli, F., Montalbano, M. C., De Paoli, L., Reda, G., Orsucci, L., Trentin, L., Cuneo, A., Tedeschi, A., Scarfo', L., Gaidano, G., Mauro, F. R., Foa, R., Boccadoro, M., and Coscia, M.
Subjects: Adult, Male, Oncology, medicine.medical_specialty, Chronic lymphocytic leukemia, Immunology, Biochemistry, Autoimmune Diseases, NO, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Piperidines, hemic and lymphatic diseases, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Aged, Quinazolinones, Aged, 80 and over, Sulfonamides, Cytopenia, business.industry, Venetoclax, Adenine, Incidence (epidemiology), Cell Biology, Hematology, Middle Aged, Bridged Bicyclo Compounds, Heterocyclic, medicine.disease, Leukemia, Lymphocytic, Chronic, B-Cell, Settore MED/15 - MALATTIE DEL SANGUE, chemistry, Purines, 030220 oncology & carcinogenesis, Ibrutinib, Female, Autoimmune hemolytic anemia, Idelalisib, IGHV@, business, chronic lymphocytic leukaemia, Immunosuppressive Agents, 030215 immunology
Abstract: Autoimmune cytopenias (AICs) affect 5% to 9% of patients with chronic lymphocytic leukemia (CLL). Targeted drugs—ibrutinib, idelalisib, and venetoclax—have a prominent role in the treatment of CLL, but their impact on CLL-associated AICs is largely unknown. In this study, we evaluated the characteristics and outcome of preexisting AICs and described the incidence, quality, and management of treatment-emergent AICs during therapy with targeted drugs in patients with CLL. We collected data from 572 patients treated with ibrutinib (9% in combination with an anti-CD20 monoclonal antibody), 143 treated with idelalisib-rituximab, and 100 treated with venetoclax (12% in combination with an anti-CD20 monoclonal antibody). A history of preexisting AICs was reported in 104 (13%) of 815 patients. Interestingly, 80% of patients whose AICs had not resolved when treatment with a targeted drug was started experienced an improvement or a resolution during therapy. Treatment-emergent AICs occurred in 1% of patients during ibrutinib therapy, in 0.9% during idelalisib therapy, and in 7% during venetoclax therapy, with an estimated incidence rate of 5, 6, and 69 episodes per 1000 patients per year of exposure in the 3 treatment groups, respectively. The vast majority of patients who developed treatment-emergent AICs had unfavorable biological features such as an unmutated IGHV and a del(17p) and/or TP53 mutation. Notably, despite AICs, 83% of patients were able to continue the targeted drug, in some cases in combination with additional immunosuppressive agents. Overall, treatment with ibrutinib, idelalisib, or venetoclax seems to have a beneficial impact on CLL-associated AICs, inducing an improvement or even a resolution of preexisting AICs in most cases and eliciting treatment-emergent AICs in a negligible portion of patients.
Published: 2021

45. Periodic Representations and Approximations of p-adic Numbers Via Continued Fractions

Author: Stefano Barbero, Umberto Cerruti, and Nadir Murru
Subjects: General Mathematics
Published: 2021

46. Duration of untreated illness and bipolar disorder: time for a new definition? Results from a cross-sectional study

Author: Giovanna Fico, Ana González-Pinto, Diego Hidalgo-Mazzei, Andrea Murru, Martin Alda, Mirko Manchia, Andre F. Carvalho, Eduard Vieta, Gerard Anmella, Carlota de Miquel, and Marta Gómez-Ramiro
Subjects: medicine.medical_specialty, Treatment response, Bipolar Disorder, Lithium (medication), Cross-sectional study, Lamotrigine, Cognition, Recall bias, Internal medicine, Manic-depressive illness, Humans, Medicine, Bipolar disorder, Retrospective Studies, Trastorn bipolar, business.industry, Valproic Acid, Psychodiagnostics, Trastorns afectius, medicine.disease, Affective disorders, Psychiatry and Mental health, Clinical Psychology, Cross-Sectional Studies, Cognició, Cohort, Psicodiagnòstic, business, medicine.drug
Abstract: Background: We primarily aimed to explore the associations between duration of untreated illness (DUI), treatment response, and functioning in a cohort of patients with bipolar disorder (BD). Methods: 261 participants with BD were recruited. DUI was defined as months from the first affective episode to the start of a mood-stabilizer. The functioning assessment short test (FAST) scores and treatment response scores for lithium, valproate, or lamotrigine according to the Alda Scale Total Score (TS) were compared between patients with short (
Published: 2021

47. Exploring Digital Biomarkers of Illness Activity in Mood Episodes: Hypotheses Generating and Model Development Study (Preprint)

Author: Gerard Anmella, Filippo Corponi, Bryan M Li, Ariadna Mas, Miriam Sanabra, Isabella Pacchiarotti, Marc Valentí, Iria Grande, Antoni Benabarre, Anna Giménez-Palomo, Marina Garriga, Isabel Agasi, Anna Bastidas, Myriam Cavero, Tabatha Fernández-Plaza, Néstor Arbelo, Miquel Bioque, Clemente García-Rizo, Norma Verdolini, Santiago Madero, Andrea Murru, Silvia Amoretti, Anabel Martínez-Aran, Victoria Ruiz, Giovanna Fico, Michele De Prisco, Vincenzo Oliva, Aleix Solanes, Joaquim Radua, Ludovic Samalin, Allan H Young, Eduard Vieta, Antonio Vergari, and Diego Hidalgo-Mazzei
Abstract: BACKGROUND Depressive and manic episodes within bipolar disorder (BD) and major depressive disorder (MDD) involve altered mood, sleep, and activity, alongside physiological alterations wearables can capture. OBJECTIVE Firstly, we explored whether physiological wearable data could predict (aim 1) the severity of an acute affective episode at the intra-individual level and (aim 2) the polarity of an acute affective episode and euthymia among different individuals. Secondarily, we explored which physiological data were related to prior predictions, generalization across patients, and associations between affective symptoms and physiological data. METHODS We conducted a prospective exploratory observational study including patients with BD and MDD on acute affective episodes (manic, depressed, and mixed) whose physiological data were recorded using a research-grade wearable (Empatica E4) across 3 consecutive time points (acute, response, and remission of episode). Euthymic patients and healthy controls were recorded during a single session (approximately 48 h). Manic and depressive symptoms were assessed using standardized psychometric scales. Physiological wearable data included the following channels: acceleration (ACC), skin temperature, blood volume pulse, heart rate (HR), and electrodermal activity (EDA). Invalid physiological data were removed using a rule-based filter, and channels were time aligned at 1-second time units and segmented at window lengths of 32 seconds, as best-performing parameters. We developed deep learning predictive models, assessed the channels’ individual contribution using permutation feature importance analysis, and computed physiological data to psychometric scales’ items normalized mutual information (NMI). We present a novel, fully automated method for the preprocessing and analysis of physiological data from a research-grade wearable device, including a viable supervised learning pipeline for time-series analyses. RESULTS Overall, 35 sessions (1512 hours) from 12 patients (manic, depressed, mixed, and euthymic) and 7 healthy controls (mean age 39.7, SD 12.6 years; 6/19, 32% female) were analyzed. The severity of mood episodes was predicted with moderate (62%-85%) accuracies (aim 1), and their polarity with moderate (70%) accuracy (aim 2). The most relevant features for the former tasks were ACC, EDA, and HR. There was a fair agreement in feature importance across classification tasks (Kendall W=0.383). Generalization of the former models on unseen patients was of overall low accuracy, except for the intra-individual models. ACC was associated with “increased motor activity” (NMI>0.55), “insomnia” (NMI=0.6), and “motor inhibition” (NMI=0.75). EDA was associated with “aggressive behavior” (NMI=1.0) and “psychic anxiety” (NMI=0.52). CONCLUSIONS Physiological data from wearables show potential to identify mood episodes and specific symptoms of mania and depression quantitatively, both in BD and MDD. Motor activity and stress-related physiological data (EDA and HR) stand out as potential digital biomarkers for predicting mania and depression, respectively. These findings represent a promising pathway toward personalized psychiatry, in which physiological wearable data could allow the early identification and intervention of mood episodes.
Published: 2022

48. Chronic graft vs. host disease and hypogammaglobulinemia predict a lower immunological response to the BNT162b2 mRNA COVID-19 vaccine after allogeneic hematopoietic stem cell transplantation

Author: L, Barabino, A, Galitzia, R, Murru, G, Caocci, C, Targhetta, M, Greco, G, Angioni, O, Mulas, A, Vacca, E, Piras, V, Frau, A, Costa, and G, La Nasa
Abstract: Due to the high mortality rate of COVID-19, the assessment of BNT162b2 SARS-CoV-2 mRNA vaccine (Pfizer-BioNTech) efficacy in allogeneic hematopoietic stem cell transplant (HSCT) recipients is mandatory.We conducted a single-center pilot study with the main objective of evaluating the immunogenicity of the BNT162b2 mRNA vaccine in 31 hematological patients who underwent hematopoietic stem cell transplantation within the previous 12 months and/or were affected by chronic graft-vs.-host-disease (cGVHD), by the assessment of antibody levels at 30-45 days after the second dose of vaccine.After the second dose of vaccine, 23 out of 31 patients (74%) showed a positive immune response. The presence of severe cGVHD or Ig deficiency identified 7 out of 8 (85%) of non-responders. The median absolute cluster of differentiation 19 (CD19) count was significantly lower in non-responders vs. responders (109/µl vs. 351/µl). Underlying pathology, comorbidities, type of donor, time intervals from transplant and cluster of differentiation 3/cluster of differentiation 4/cluster of differentiation 8 (CD3/CD4/CD8) subsets were not significantly associated with an effective immune response to vaccination.Despite the limited sample of patients enrolled, our findings suggest that hypogammaglobulinemia and cGVHD could be associated with poor humoral response to the BNT162b2.
Published: 2022

49. Antidepressants overuse in primary care: Prescription trends between 2010 and 2019 in Catalonia

Author: Gerard Anmella, Miriam Sanabra, Mireia Primé-Tous, Xavier Segú, Aleix Solanes, Victoria Ruíz, Ivette Morilla, Antonieta Also Fontanet, Elisenda Sant, Sandra Murgui, Mireia Sans-Corrales, Anabel Martínez-Aran, Giovanna Fico, Michele De Prisco, Vincenzo Oliva, Andrea Murru, Roland Zahn, Allan H. Young, Victor Vicens, Clara Viñas-Bardolet, Vicenç Aparicio-Nogué, Juan Francisco Martínez-Cerdá, Ariadna Mas, Bernat Carreras, Jordi Blanch, Joaquim Radua, Miquel A. Fullana, Myriam Cavero, Eduard Vieta, and Diego Hidalgo-Mazzei
Subjects: Psychiatry and Mental health
Published: 2022

50. A new algorithm for p-adic continued fractions

Author: Murru, Nadir and Romeo, Giuliano
Subjects: Mathematics - Number Theory, FOS: Mathematics, 11J70, 11D88, 11Y65, Number Theory (math.NT)
Abstract: Continued fractions in the field of $p$--adic numbers have been recently studied by several authors. It is known that the real continued fraction of a positive quadratic irrational is eventually periodic (Lagrange's Theorem). It is still not known if a $p$--adic continued fraction algorithm exists that shares a similar property. In this paper we modify and improve one of Browkin's algorithms. This algorithm is considered one of the best at the present time. Our new algorithm shows better properties of periodicity. We show for the square root of integers that if our algorithm produces a periodic expansion, then this periodic expansion will have pre-period one. It appears experimentally that our algorithm produces more periodic continued fractions for quadratic irrationals than Browkin's algorithm. Hence, it is closer to an algorithm to which an analogue of Lagrange's Theorem would apply., 23 pages
Published: 2022

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