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11 results on '"Murohara, T"'

1. Highly purified eicosapentaenoic acid ameliorates cardiac injury and adipose tissue inflammation in a rat model of metabolic syndrome

Author

Ito, S., Sano, Y., Nagasawa, K., Matsuura, N., Yamada, Y., Uchinaka, A., Murohara, T., and Nagata, K.

Subjects
eicosapentaenoic acid, inflammation, Original Article, Original Articles, Adiponectin, metabolic syndrome
Abstract

Summary Introduction n‐3 Polyunsaturated fatty acids such as eicosapentaenoic acid (EPA), which are abundant in fish oil, have been shown to delay the onset of cardiovascular events. We previously established DahlS.Z‐Lepr fa/Lepr fa (DS/obese) rats, which are derived from a cross between Dahl salt‐sensitive and Zucker rats, as a model of metabolic syndrome. This study has now explored the influence of highly purified EPA on cardiac and adipose tissue pathophysiology in this animal model. Materials and methods DS/obese rats were administered EPA (300 or 1,000 mg kg−1 d−1, per os) or vehicle from age 9 to 13 weeks. Homozygous lean (DahlS.Z‐Lepr +/Lepr +, or DS/lean) littermates were studied as controls. Results Whereas EPA had no effect on body weight, food intake or systolic blood pressure in DS/obese rats, it attenuated cardiac fibrosis, diastolic dysfunction, oxidative stress and inflammation in these animals. In addition, EPA did not affect insulin resistance but reduced adipocyte hypertrophy and inflammation in visceral fat of DS/obese rats. Moreover, EPA increased circulating levels of adiponectin as well as attenuated both the down‐regulation of AMP‐activated protein kinase phosphorylation and the up‐regulation of phosphorylation of the p65 subunit of nuclear factor‐kB in the heart of DS/obese rats. Conclusions Treatment of DS/obese rats with EPA did not affect hypertension but reduced cardiac fibrosis and diastolic dysfunction, with the latter effects being accompanied by AMP‐activated protein kinase activation and inactivation of nuclear factor‐kB signalling in the heart, possibly as a result of an increase in adiponectin secretion. EPA may be suitable for the treatment of cardiac injury associated with metabolic syndrome.

Published
2016

2. Adiponectin promotes endothelial progenitor cell numberand function

Author

Shibata R, Skurk C, Ouchi N, Kondo K, Ohashi T, Shimano M, Kihara S, Murohara T, Walsh K., GALASSO, GENNARO, Shibata, R, Skurk, C, Ouchi, N, Galasso, Gennaro, Kondo, K, Ohashi, T, Shimano, M, Kihara, S, Murohara, T, and Walsh, K.

Abstract

Obesity-linked diseases are associated with suppressed endothelial progenitor cell (EPC) function. Adiponectin is an adipose-derived protein that is downregulated in obese and diabetic subjects. Here, we investigated the effects of adiponectin on EPCs. EPC levels did not increase in adiponectin deficient (APN-KO) in response to hindlimb ischemia. Adenovirus-mediated delivery of adiponectin increased EPC levels in both WT and APN-KO mice. Incubation of human peripheral blood mononuclear cells with adiponectin led to an increase of the number of EPCs. Adiponectin induced EPC differentiation into network structures and served as a chemoattractant in EPC migration assays. These data suggest that hypoadiponectinemia may contribute to the depression of EPC levels that are observed in patients with obesity-related cardiovascular disorders

Published
2008

4. CD34+-cells home, proliferate and participate in capillary formation, and in combination with CD34-_cells markedly enhance neovascularization in a 3D-matrix

Author

Rookmaaker, M.B., Verhaar, M.C., Loomans, C.J.M., Verloop, R., Peters, E.D.J., Westerweel, P.E., Murohara, T., Staal, F.J.T., and van Zonneveld, A.J.

Subjects
Econometric and Statistical Methods: General, Other medical specialities, Geneeskunde (GENK), Bescherming en bevordering van de menselijke gezondheid, Geneeskunde(GENK), General [Econometric and Statistical Methods]
Published
2005

10. Fulminant Versus Acute Nonfulminant Myocarditis in Patients With Left Ventricular Systolic Dysfunction

Author

Emeline M. Van Craenenbroeck, Maria Frigerio, Sean Pinney, Victor Garcia-Hernando, Akihiro Isotani, Akinori Sawamura, Jessica Artico, Barry H. Greenberg, Luciano Potena, Piero Gentile, Sherin Hashem, Fabrizio Oliva, Claudia Raineri, Paolo G. Camici, Santiago Montero, Giacomo Veronese, Yoh Arita, Manlio Cipriani, Florent Huang, Enrico Fabris, Alessandro Sionis, Palak Shah, Alberto Foà, Oscar Ö. Braun, Hiroaki Shimokawa, Matthieu Schmidt, Ornella Leone, Marco Merlo, Toyoaki Murohara, Anuradha Lala, Paola Sormani, Caroline M. Van De Heyning, Michela Brambatti, Enrico Ammirati, Takahiro Okumura, Andrea Garascia, Koichiro Sugimura, Marisa Varrenti, Eric Adler, Rajiv Patel, Kaoru Hirose, Kimberly N. Hong, Tatsuo Aoki, Gianfranco Sinagra, Duccio Petrella, Valentina Agostini, Ammirati, E., Veronese, G., Brambatti, M., Merlo, M., Cipriani, M., Potena, L., Sormani, P., Aoki, T., Sugimura, K., Sawamura, A., Okumura, T., Pinney, S., Hong, K., Shah, P., Braun, O., Van de Heyning, C. M., Montero, S., Petrella, D., Huang, F., Schmidt, M., Raineri, C., Lala, A., Varrenti, M., Foa, A., Leone, O., Gentile, P., Artico, J., Agostini, V., Patel, R., Garascia, A., Van Craenenbroeck, E. M., Hirose, K., Isotani, A., Murohara, T., Arita, Y., Sionis, A., Fabris, E., Hashem, S., Garcia-Hernando, V., Oliva, F., Greenberg, B., Shimokawa, H., Sinagra, G., Adler, E. D., Frigerio, M., Camici, P. G., Ammirati E., Veronese G., Brambatti M., Merlo M., Cipriani M., Potena L., Sormani P., Aoki T., Sugimura K., Sawamura A., Okumura T., Pinney S., Hong K., Shah P., Braun O., Van de Heyning C.M., Montero S., Petrella D., Huang F., Schmidt M., Raineri C., Lala A., Varrenti M., Foà Alberto., Leone O., Gentile P., Artico J., Agostini V., Patel R., Garascia A., Van Craenenbroeck E.M., Hirose K., Isotani A., Murohara T., Arita Y., Sionis A., Fabris E., Hashem S., Garcia-Hernando V., Oliva F., Greenberg B., Shimokawa H., Sinagra G., Adler E.D., Frigerio M., Camici P.G., Ammirati, E, Veronese, G, Brambatti, M, Merlo, M, Cipriani, M, Potena, L, Sormani, P, Aoki, T, Sugimura, K, Sawamura, A, Okumura, T, Pinney, S, Hong, K, Shah, P, Braun, O, Van de Heyning, C, Montero, S, Petrella, D, Huang, F, Schmidt, M, Raineri, C, Lala, A, Varrenti, M, Foa, A, Leone, O, Gentile, P, Artico, J, Agostini, V, Patel, R, Garascia, A, Van Craenenbroeck, E, Hirose, K, Isotani, A, Murohara, T, Arita, Y, Sionis, A, Fabris, E, Hashem, S, Garcia-Hernando, V, Oliva, F, Greenberg, B, Shimokawa, H, Sinagra, G, Adler, E, Frigerio, M, and Camici, P

Subjects
Adult, Male, Inotrope, medicine.medical_specialty, Myocarditis, eosinophilic myocarditi, Prognosi, Fulminant, medicine.medical_treatment, Myocarditi, fulminant myocarditis, 030204 cardiovascular system & hematology, Severity of Illness Index, acute myocarditis, endomyocardial biopsy, eosinophilic myocarditis, giant cell myocarditis, outcome, Endomyocardial biopsy, Ventricular Dysfunction, Left, 03 medical and health sciences, 0302 clinical medicine, Retrospective Studie, Internal medicine, giant cell myocarditi, Humans, Medicine, In patient, 030212 general & internal medicine, Retrospective Studies, Heart transplantation, fulminant myocarditi, business.industry, Middle Aged, Prognosis, medicine.disease, acute myocarditi, Acute myocarditis, Acute Disease, Circulatory system, Cardiology, Female, Human medicine, Cardiology and Cardiovascular Medicine, business, Human
Abstract

BACKGROUND Fulminant myocarditis (FM) is a form of acute myocarditis characterized by severe left ventricular systolic dysfunction requiring inotropes and/or mechanical circulatory support. A single-center study found that a patient with FM had better outcomes than those with acute nonfulminant myocarditis (NFM) presenting with left ventricular systolic dysfunction, but otherwise hemodynamically stable. This was recently challenged, so disagreement still exists. OBJECTIVES This study sought to provide additional evidence on the outcome of FM and to ascertain whether patient stratification based on the main histologic subtypes can provide additional prognostic information. METHODS A total of 220 patients (median age 42 years, 46.3% female) with histologically proven acute myocarditis (onset of symptoms

Published
2019
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11. Viral genome search in myocardium of patients with fulminant myocarditis

Author

Alberto Foà, Victor Garcia-Hernando, Michela Brambatti, Hiroaki Shimokawa, Paola Sormani, Anuradha Lala, Sean Pinney, Duccio Petrella, Maria Frigerio, Gianfranco Sinagra, Valentina Agostini, Matthieu Schmidt, Piero Gentile, Akihiro Isotani, Enrico Ammirati, Enrico Fabris, Ornella Leone, Luciano Potena, Sherin Hashem, Barry H. Greenberg, Santiago Montero, Jessica Artico, Caroline M. Van De Heyning, Giacomo Veronese, Marco Merlo, Alessandro Sionis, Palak Shah, Emeline M. Van Craenenbroeck, Florent Huang, Claudia Raineri, Yoh Arita, Tatsuo Aoki, Fabrizio Oliva, Akinori Sawamura, Manlio Cipriani, Koichiro Sugimura, Marisa Varrenti, Oscar Ö. Braun, Eric Adler, Paolo G. Camici, Toyoaki Murohara, Andrea Garascia, Takahiro Okumura, Kimberly N. Hong, Kaoru Hirose, Rajiv Patel, Veronese, G., Ammirati, E., Brambatti, M., Merlo, M., Cipriani, M., Potena, L., Sormani, P., Aoki, T., Sugimura, K., Sawamura, A., Okumura, T., Pinney, S., Hong, K., Shah, P., Braun, O. O., Van de Heyning, C. M., Montero, S., Petrella, D., Huang, F., Schmidt, M., Raineri, C., Lala, A., Varrenti, M., Foa, A., Leone, O., Gentile, P., Artico, J., Agostini, V., Patel, R., Garascia, A., Van Craenenbroeck, E. M., Hirose, K., Isotani, A., Murohara, T., Arita, Y., Sionis, A., Fabris, E., Hashem, S., Garcia-Hernando, V., Oliva, F., Greenberg, B., Shimokawa, H., Sinagra, G., Adler, E. D., Frigerio, M., Camici, P. G., Veronese G., Ammirati E., Brambatti M., Merlo M., Cipriani M., Potena L., Sormani P., Aoki T., Sugimura K., Sawamura A., Okumura T., Pinney S., Hong K., Shah P., Braun O.O., Van de Heyning C.M., Montero S., Petrella D., Huang F., Schmidt M., Raineri C., Lala A., Varrenti M., Foà Alberto, Leone O., Gentile P., Artico J., Agostini V., Patel R., Garascia A., Van Craenenbroeck E.M., Hirose K., Isotani A., Murohara T., Arita Y., Sionis A., Fabris E., Hashem S., Garcia-Hernando V., Oliva F., Greenberg B., Shimokawa H., Sinagra G., Adler E.D., Frigerio M., Camici P.G., CIC Pitié BT, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université - Faculté de Médecine (SU FM), and Sorbonne Université (SU)

Subjects
Letter, Fulminant, [SDV]Life Sciences [q-bio], polymerase chain reaction, Biopsy, Cytomegalovirus, heart failure, fulminant myocarditis, 030204 cardiovascular system & hematology, medicine.disease_cause, 0302 clinical medicine, Medicine, genetics, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, virus replication, Enterovirus, genome analysis, Genome search, predictive value, Epstein Barr virus, Myocarditis, priority journal, N/A, Cardiology and Cardiovascular Medicine, left ventricular systolic dysfunction, Human, cardiac muscle, Genome, Viral, Adenoviridae, 03 medical and health sciences, Humans, human, virus identification, virus detection, Heart Failure, nonhuman, business.industry, Myocardium, medicine.disease, Epstein–Barr virus, Virology, Virus detection, virus genome, Viral replication, Human medicine, business
Abstract

[No abstract available]

Published
2020
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