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1. Real-Time MIMO Transmission over Field-Deployed Coupled-Core Multi-Core Fibers

Author

Mazur, M., Ryf, R., Fontaine, N. K., Marotta, A., Borjeson, E., Dallachiesa, L., Chen, H., Hayashi, T., Nagashima, T., Nakanishi, T., Morishima, T., Graziosi, F., Palmieri, L., Neilson, D. T., Larsson-Edefors, P., Mecozzi, A., and Antonelli, C.

Abstract

We perform parallel continuous measurements of deployed SDM fibers u sing real-time coherent receivers implemented on FPGAs. Fast readouts enabling real-time tracking of the DSP implementation, showing that coupled-core fibers are compatible with real-time DSP implementations.

Published
2022

2. New high-sensitivity searches for neutrons converting into antineutrons and/or sterile neutrons at the European Spallation Source

Author

Addazi, A., Anderson, K., Ansell, S., Babu, K., Barrow, J., Baxter, D. V., Bentley, P. M., Berezhiani, Z., Bevilacqua, R., Bohm, C., Brooijmans, G., Broussard, J., Biondi, R., Dev, B., Crawford, C., Dolgov, A., Dunne, K., Fierlinger, P., Fitzsimmons, M. R., Fomin, A., Frost, M., Gardner, S., Galindo-Uribarri, A., Golubeva, E., Girmohanta, S., Greene, G. L., Greenshaw, T., Gudkov, V., Hall-Wilton, R., Heilbronn, L., Herrero-Garcia, J., Ito, G. Ichikawa T. M., Iverson, E., Johansson, T., Joensson, L., Jwa, Y-J., Kamyshkov, Y., Kanaki, K., Kearns, E., Kitaguchi, M., Kittelmann, T., Klinkby, E., Koerner, L. W., Kopeliovich, B., Kozela, A., Kudryatsev, V., Kupsc, A., Lee, Y., Lindroos, M., Makkinje, J., Marquez, J. I., Mohapatra, R., Meirose, B., Miller, T. M., Milstead, D., Morishima, T., Muhrer, G., Mumm, H. P., Nagamoto, K., Nesvizhevsky, V. V., Nilsson, T., Oskarsson, A., Paryev, E., Pattie, R. W., Penttil, S., Pokotilovski, Y. N., Potashnikova, I., Redding, C., Richard, J-M, Ries, D., Rinaldi, E., Ruggles, A., Rybolt, B., Santoro, V., Sarkar, U., Saunders, A., Senjanovic, G., Serebrov, A. P., Shimizu, H. M., Shrock, R., Silverstein, S., Silvermyr, D., Snow, W. M., Takibayev, A., Townsend, L., Tkachev, I., Varriano, L., Vainshtein, A., de VRies, J., Woracek, R., Yamagata, Y., Young, A. R., Zanini, L., Zhang, Z., and Zimmer, O.

Subjects
High Energy Physics - Experiment (hep-ex), Physics - Instrumentation and Detectors, Nuclear Theory, High Energy Physics::Phenomenology, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), Nuclear Experiment, High Energy Physics - Experiment
Abstract

The violation of Baryon Number, $\mathcal{B}$, is an essential ingredient for the preferential creation of matter over antimatter needed to account for the observed baryon asymmetry in the universe. However, such a process has yet to be experimentally observed. The HIBEAM/NNBAR %experiment program is a proposed two-stage experiment at the European Spallation Source (ESS) to search for baryon number violation. The program will include high-sensitivity searches for processes that violate baryon number by one or two units: free neutron-antineutron oscillation ($n\rightarrow \bar{n}$) via mixing, neutron-antineutron oscillation via regeneration from a sterile neutron state ($n\rightarrow [n',\bar{n}'] \rightarrow \bar{n}$), and neutron disappearance ($n\rightarrow n'$); the effective $\Delta \mathcal{B}=0$ process of neutron regeneration ($n\rightarrow [n',\bar{n}'] \rightarrow n$) is also possible. The program can be used to discover and characterise mixing in the neutron, antineutron, and sterile neutron sectors. The experiment addresses topical open questions such as the origins of baryogenesis, the nature of dark matter, and is sensitive to scales of new physics substantially in excess of those available at colliders. A goal of the program is to open a discovery window to neutron conversion probabilities (sensitivities) by up to three orders of magnitude compared with previous searches. The opportunity to make such a leap in sensitivity tests should not be squandered. The experiment pulls together a diverse international team of physicists from the particle (collider and low energy) and nuclear physics communities, while also including specialists in neutronics and magnetics.

Published
2020

3. Mission Design of LiteBIRD

Author

Borrill, J., Dobbs, M., Ghribi, A., Holzapfel, W., Kimura, K., Koga, K., Kozu, M., Komatsu, E., Lee, A., Mima, S., Mizukami, K., Morii, H., Morishima, T., Murayama, S., Nagai, M., Nagata, R., Nakamura, S., Naruse, M., Natsume, K., Nishino, H., Noguchi, T., Ogawa, H., Oguri, S., Ohta, I., Otani, C., Richards, P., Sato, N., Sekimoto, Y., Shimizu, A., Suzuki, T., Suzuki, A., Tajima, O., Takada, S., Takakura, S., Tomaru, T., Uzawa, Y., Watanabe, H., Yoshida, M., Matsumura, Tomotake, Akiba, Yoshiki, Chinone, Yuji, Fuke, Hideyuki, Hasegawa, M., Hattori, K., Hattori, Makoto, Hazumi, M., Inoue, Yuki, Ishidoshiro, Koji, Ishino, H., Ishitsuka, H., Karatsu, K., Katayama, N., Kawano, Isao, Kibayashi, A., Kibe, Y., Kimura, Nobuhiro, Matsuhara, Hideo, Mitsuda, Kazuhisa, Nishibori, Toshiyuki, Noda, Atsushi, Sakai, Shinichiro, Sato, Yoichi, Shinozaki, Keisuke, Sugita, Hiroyuki, Takei, Yoh, Wada, Takehiko, Yamasaki, Noriko, Yoshida, Tetsuya, and Yotsumoto, Kazuhiko

Subjects
Cosmology and Nongalactic Astrophysics (astro-ph.CO), Physics::Instrumentation and Detectors, Cosmic microwave background, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, law.invention, Cosmic microwave background radiation, Optics, law, B-mode polarization, Transition edge sensor bolometer for space application, General Materials Science, Instrumentation and Methods for Astrophysics (astro-ph.IM), Physics, business.industry, Gravitational wave, Bolometer, Astrophysics::Instrumentation and Methods for Astrophysics, Polarimeter, Condensed Matter Physics, Polarization (waves), Inflation, Atomic and Molecular Physics, and Optics, Cardinal point, Transition edge sensor, Astrophysics - Instrumentation and Methods for Astrophysics, business, Microwave, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

著者人数: 69名, Accepted: 2013-11-29, 資料番号: SA1004860000

Published
2014

4. Novel thermal error reduction techniques in temperature domain

Author

Morishima, T., Munnig Schmidt, R.H., van Ostayen, R.A.J., and Delft University of Technology

Abstract

The relative importance of thermal errors in precision machines has increased in recent years. The requirements on precision machines such as higher precision and higher productivity become more stringent over product generations. Improved precision of precision machines has increased the importance of thermal errors in precision machines. To increase the productivity of precision machines, more energy needs to be consumed in general, resulting in increased heat generation and thermal errors, and poorer precision performance. To further improve the precision of precision machines while achieving increased productivity at the same time, thermal errors in precision machines need to be studied and reduced further.

Published
2016

5. LiteBIRD: Mission Overview and Focal Plane Layout

Author

Nagasaki, T., Nagata, R., Nakajima, M., Nakamura, S., Namikawa, T., Naruse, M., Natsume, K., Arnold, K., Borrill, J., Chendra, R., Cukierman, A., de, Haan T., Dobbs, M., Dominjon, A., Elleflot, T., Errard, J., Fujino, T., Goeckner-wald, N., Halverson, N., Harvey, P., Hill, C., Hilton, G., Holzapfel, W., Hori, Y., Hubmayr, J., Ichiki, K., Inatani, J., Inoue, M., Irie, F., Irwin, K., Jeong, O., Kashima, S., Keating, B., Kida, Y., Nishino, H., Kimura, K., Kohri, K., Komatsu, E., Kuo, C. L., Kuromiya, S., Kusaka, A., Lee, A., Linder, E., Nitta, T., Matsuoka, S., Matsuura, S., Mima, S., Mizukami, K., Morii, H., Morishima, T., Nagai, M., Noguchi, T., Ogawa, H., Oguri, S., Ohta, I. S., Otani, C., Okada, N., Okamoto, A., Okamura, T., Rebeiz, G., Richards, P., Sato, N., Segawa, Y., Sekiguchi, S., Sekimoto, Y., Sekine, M., Seljak, U., Sherwin, B., Shu, S., Stompor, R., Sugai, H., Suzuki, T., Suzuki, A., Tajima, O., Takada, S., Takakura, S., Takano, K., Tomaru, T., Tomita, N., Turin, P., Utsunomiya, S., Uzawa, Y., Watanabe, H., Westbrook, B., Whitehorn, N., Yamada, Y., Yamashita, T., Yoshida, M., Matsumura, Tomotake, Akiba, Yoshiki, Chinone, Yuji, Kibe, Y., Kimura, Nobuhiro, Matsuhara, Hideo, Mitsuda, Kazuhisa, Nishibori, Toshiyuki, Nishijo, Kunitoshi, Noda, Atsushi, Wada, Takehiko, Sakai, Shinichiro, Sato, Yoichi, Shinozaki, Keisuke, Sugita, Hiroyuki, Yamasaki, Noriko, Yoshida, Tetsuya, Yotsumoto, Y., Fuke, Hideyuki, Hattori, Makoto, Hasegawa, M., Hattori, K., Hazumi, M., Takei, Yoh, Inoue, Yuki, Ishino, H., Ishitsuka, H., Karatsu, K., Katayama, N., Kawano, Isao, Kibayashi, A., California Institute of Technology (CALTECH), Department of Geological Sciences [BYU], Brigham Young University (BYU), Lawrence Berkeley National Laboratory [Berkeley] (LBNL), McGill University = Université McGill [Montréal, Canada], Franche-Comté Électronique Mécanique, Thermique et Optique - Sciences et Technologies (UMR 6174) (FEMTO-ST), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), University of Ottawa [Ottawa], National Institute of Standards and Technology [Gaithersburg] (NIST), Commissariat à l'énergie atomique et aux énergies alternatives - Laboratoire d'Electronique et de Technologie de l'Information (CEA-LETI), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Department of Advanced Materials, University of Tokyo, Department of Advanced Materials, Environmental Molecular Biology Laboratory (RIKEN), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), Department of Physics, Nara Women's University, Department of Organic and Polymer Materials Chemistry, Tokyo University of Agriculture and Technology (TUAT), Japan Atomic Energy Agency [Ibaraki] (JAEA), Graduate School of Biological Sciences, Nara Institute of Science and Technology, Institut de RadioAstronomie Millimétrique (IRAM), Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Advanced Science Research Center and Nuclear Science Research Institute, Japan Atomic Energy Agency, Japan Atomic Energy Agency, Institute of laser Engineering, Osaka University [Osaka], Space Sciences Laboratory [Berkeley] (SSL), University of California [Berkeley] (UC Berkeley), University of California (UC)-University of California (UC), Institut de biologie et chimie des protéines [Lyon] (IBCP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), McGill University, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7), Université de Franche-Comté (UFC)-Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Technologie de Belfort-Montbeliard (UTBM), University of Ottawa [Ottawa] (uOttawa), Laboratoire d'Electronique et des Technologies de l'Information (CEA-LETI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), Japan Atomic Energy Agency (JAEA), Nuclear Science and Engineering Directorate, Nanomaterials Research Institute, University of California [Berkeley], University of California-University of California, Nanoscience and Surface Chemistry Laboratory, Department of Geological Sciences, University of Michigan, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Dept. of Physics, University of Wisconsin-Madison, Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université de Technologie de Belfort-Montbeliard (UTBM)-Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM)-Université de Franche-Comté (UFC), and Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Primordial B-mode, media_common.quotation_subject, Cosmic microwave background, Lagrangian point, Astrophysics::Cosmology and Extragalactic Astrophysics, CMB, 01 natural sciences, law.invention, Optics, law, Polarization, 0103 physical sciences, General Materials Science, 010303 astronomy & astrophysics, ComputingMilieux_MISCELLANEOUS, media_common, Physics, [PHYS]Physics [physics], 010308 nuclear & particles physics, business.industry, Bolometer, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Condensed Matter Physics, Polarization (waves), Inflation, Atomic and Molecular Physics, and Optics, Cardinal point, TES bolometer, MKID, Satellite, Sky, business, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Microwave
Abstract

著者人数: 120名, Accepted: 2016-02-01, 資料番号: SA1150339000

Published
2016

6. LiteBIRD: Mission Overview and Focal Plane Layout

Author

Matsumura, T, Akiba, Y, Arnold, K, Borrill, J, Chendra, R, Chinone, Y, Cukierman, A, de Haan, T, Dobbs, M, Dominjon, A, Elleflot, T, Errard, J, Fujino, T, Fuke, H, Goeckner-wald, N, Halverson, N, Harvey, P, Hasegawa, M, Hattori, K, Hattori, M, Hazumi, M, Hill, C, Hilton, G, Holzapfel, W, Hori, Y, Hubmayr, J, Ichiki, K, Inatani, J, Inoue, M, Inoue, Y, Irie, F, Irwin, K, Ishino, H, Ishitsuka, H, Jeong, O, Karatsu, K, Kashima, S, Katayama, N, Kawano, I, Keating, B, Kibayashi, A, Kibe, Y, Kida, Y, Kimura, K, Kimura, N, Kohri, K, Komatsu, E, Kuo, CL, Kuromiya, S, Kusaka, A, Lee, A, Linder, E, Matsuhara, H, Matsuoka, S, Matsuura, S, Mima, S, Mitsuda, K, Mizukami, K, Morii, H, Morishima, T, Nagai, M, Nagasaki, T, Nagata, R, Nakajima, M, Nakamura, S, Namikawa, T, Naruse, M, Natsume, K, Nishibori, T, Nishijo, K, Nishino, H, Nitta, T, Noda, A, Noguchi, T, Ogawa, H, Oguri, S, Ohta, IS, Otani, C, Okada, N, Okamoto, A, Okamura, T, Rebeiz, G, Richards, P, Sakai, S, Sato, N, Sato, Y, Segawa, Y, Sekiguchi, S, Sekimoto, Y, Sekine, M, Seljak, U, Sherwin, B, Shinozaki, K, Shu, S, Stompor, R, Sugai, H, Sugita, H, Suzuki, T, and Suzuki, A

Subjects
General Physics, TES bolometer, MKID, Satellite, Polarization, Primordial B-mode, Classical Physics, Astrophysics::Instrumentation and Methods for Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics, CMB, Condensed Matter Physics, Inflation, Mathematical Physics
Abstract

LiteBIRD is a proposed CMB polarization satellite project to probe the inflationary B-mode signal. The satellite is designed to measure the tensor-to-scalar ratio with a 68% confidence level uncertainty of σr< 10 - 3, including statistical, instrumental systematic, and foreground uncertainties. LiteBIRD will observe the full sky from the second Lagrange point for 3years. We have a focal plane layout for observing frequency coverage that spans 40–402 GHz to characterize the galactic foregrounds. We have two detector candidates, transition-edge sensor bolometers and microwave kinetic inductance detectors. In both cases, a telecentric focal plane consists of approximately 2 × 10 3 superconducting detectors. We will present the mission overview of LiteBIRD, the project status, and the TES focal plane layout.

Published
2016

7. LiteBIRD: Mission Overview and Focal Plane Layout

Author

Matsumura, T, Akiba, Y, Arnold, K, Borrill, J, Chendra, R, Chinone, Y, Cukierman, A, de Haan, T, Dobbs, M, Dominjon, A, Elleflot, T, Errard, J, Fujino, T, Fuke, H, Goeckner-wald, N, Halverson, N, Harvey, P, Hasegawa, M, Hattori, K, Hattori, M, Hazumi, M, Hill, C, Hilton, G, Holzapfel, W, Hori, Y, Hubmayr, J, Ichiki, K, Inatani, J, Inoue, M, Inoue, Y, Irie, F, Irwin, K, Ishino, H, Ishitsuka, H, Jeong, O, Karatsu, K, Kashima, S, Katayama, N, Kawano, I, Keating, B, Kibayashi, A, Kibe, Y, Kida, Y, Kimura, K, Kimura, N, Kohri, K, Komatsu, E, Kuo, CL, Kuromiya, S, Kusaka, A, Lee, A, Linder, E, Matsuhara, H, Matsuoka, S, Matsuura, S, Mima, S, Mitsuda, K, Mizukami, K, Morii, H, Morishima, T, Nagai, M, Nagasaki, T, Nagata, R, Nakajima, M, Nakamura, S, Namikawa, T, Naruse, M, Natsume, K, Nishibori, T, Nishijo, K, Nishino, H, Nitta, T, Noda, A, Noguchi, T, Ogawa, H, Oguri, S, Ohta, IS, Otani, C, Okada, N, Okamoto, A, Okamura, T, Rebeiz, G, Richards, P, Sakai, S, Sato, N, Sato, Y, Segawa, Y, Sekiguchi, S, Sekimoto, Y, Sekine, M, Seljak, U, Sherwin, B, Shinozaki, K, Shu, S, and Stompor, R

Subjects
Astrophysics::Instrumentation and Methods for Astrophysics, Astrophysics::Cosmology and Extragalactic Astrophysics
Abstract

© 2016, Springer Science+Business Media New York. LiteBIRD is a proposed CMB polarization satellite project to probe the inflationary B-mode signal. The satellite is designed to measure the tensor-to-scalar ratio with a 68 % confidence level uncertainty of σr< 10- 3, including statistical, instrumental systematic, and foreground uncertainties. LiteBIRD will observe the full sky from the second Lagrange point for 3 years. We have a focal plane layout for observing frequency coverage that spans 40–402 GHz to characterize the galactic foregrounds. We have two detector candidates, transition-edge sensor bolometers and microwave kinetic inductance detectors. In both cases, a telecentric focal plane consists of approximately 2 × 103superconducting detectors. We will present the mission overview of LiteBIRD, the project status, and the TES focal plane layout.

Published
2016

8. How to Reduce I-V Measurement Deviation between Research and Production

Author

Takeda, Y., Kojima, H., Iwamoto, K., Fujita, Y., Morishima, T., Shibamoto, K., and Abe, J.

Subjects
Operation, Performance, Reliability and Sustainability of Photovoltaics, PV Cells and Modules
Abstract

32nd European Photovoltaic Solar Energy Conference and Exhibition; 2299-2303, I-V measurement is very important for solar cell research well as for production. The probing method is often different between them, and that may create measurement errors. We have found that FF is normally measured lower in production line than in research environment, and the deviation gets bigger as the current grows and as the bus bar gets narrower. That means we need to know how the deviation is caused by the probing differences, particularly for high-efficiency cells. We have tried various probing patterns and analyzed the cause of the measurement errors. Using the results, we will propose better probing method in order to reduce the deviation between research and production environments. In addition to the information we already published in our previous paper, this paper has added more test results and new insight.

Published
2016
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9. Detection of RBM15-MKL1 fusion was useful for diagnosis and monitoring of minimal residual disease in infant acute megakaryoblastic leukemia

Author

Takeda, A., Akira SHIMADA, Hamamoto, K., Yoshino, S., Nagai, T., Fujii, Y., Yamada, M., Nakamura, Y., Watanabe, T., Watanabe, Y., Yamamoto, Y., Sakakibara, K., Oda, M., and Morishima, T.

Subjects
Neoplasm, Residual, Oncogene Proteins, Fusion, Leukemia, Megakaryoblastic, Acute, AMKL, Antineoplastic Combined Chemotherapy Protocols, Humans, Infant, RBM15-MKL1, Female, OTT-MAL, Drug Monitoring, Polymerase Chain Reaction
Abstract

Acute megakaryocytic leukemia (AMKL) with t(1;22)(p13;q13) is a distinct category of myeloid leukemia by WHO classification and mainly reported in infants and young children. Accurate diagnosis of this type of AMKL can be difficult, because a subset of patients have a bone marrow (BM) blast percentage of less than 20% due to BM fibrosis. Therefore, it is possible that past studies have underestimated this type of AMKL. We present here the case of a 4-month-old female AMKL patient who was diagnosed by presence of the RBM15-MKL1 (OTT-MAL) fusion transcript by RT-PCR. In addition, we monitored RBM15-MKL1 fusion at several time points as a marker of minimal residual disease (MRD), and found that it was continuously negative after the first induction chemotherapy even by nested RT-PCR. Detection of the RBM15-MKL1 fusion transcript thus seems to be useful for accurate diagnosis of AMKL with t(1;22)(p13;q13). We recommend that the RBM15-MKL1 fusion transcript be analyzed for all suspected AMKL in infants and young children. Furthermore, monitoring of MRD using this fusion transcript would be useful in treatment of AMKL with t(1;22)(p13;q13).

Published
2014

11. Hepatitis G Infection

Author

Shibata M, Kudo T, and Morishima T

Subjects
Text mining, business.industry, Hepatitis G Infection, Medicine, General Medicine, business, Virology
Published
1997

12. Immunological studies on adult T cell leukaemia virus (ATLV) carriers

Author

Morishima, Y, Ohya, K, Morishima, T, Nishikawa, K, and Fukuda, T

Subjects
Adult, Male, Leukemia, Adolescent, T-Lymphocytes, Immunoglobulins, Antibodies, Viral, Hemophilia A, Deltaretrovirus, Leukocyte Count, Antigens, Surface, Carrier State, Humans, Female, Research Article
Abstract

Adult T cell leukaemia associated antibody (ATLA-Ab) positive people who were considered to be adult T cell leukaemia virus (ATLV) carriers were found in 0.75% of the adult population in the non-endemic area of Nagoya, Japan. Immunological studies on these people revealed that T lymphocyte subpopulations, as defined by nine monoclonal antibodies reactive to T lymphocyte surface antigens including T cell activation antigen, showed no differences between ATLA-Ab positive and ATLA-Ab negative individuals. Only a slightly higher percentage of Ia positive T lymphocytes was found in ATLA-Ab positive persons. Furthermore, the serum IgG level and the antibody titre of cytomegalovirus were significantly increased in ATLA-Ab positive individuals, while serum IgA, IgM level and the antibody titre of herpes simplex virus and mumps virus, showed no differences in both groups. This data suggests the possibility that ATLV carriers have some mild immunological abnormalities.

Published
1986

13. Virological aspects of Epstein-Barr virus infections

Author

Yamashita, N., Hiroshi Kimura, and Morishima, T.

Subjects
Epstein-Barr Virus Infections, Herpesvirus 4, Human, tetramer, hemic and lymphatic diseases, DNA, Viral, Humans, Infectious Mononucleosis, Epstein-Barr virus-associated hemophagocytic syndrome, Polymerase Chain Reaction, chronic active Epstein-Barr virus infection, Lymphohistiocytosis, Hemophagocytic, T-Lymphocytes, Cytotoxic, Real-time PCR
Abstract

Epstein-Barr virus (EBV) is usually maintained in an asymptomatic and latent form by the host immune system, and primarily by EBV-specific cytotoxic T cells (CTLs). However, EBV has been linked to several refractory diseases such as EBV-associated hemophagocytic syndrome(EBV-AHS) and chronic active EBV infection (CAEBV). In these ectopic diseases, EBV infects T/NK cells, causing severe immunodeficiency with a very high EBV load. In recent years, the laboratory procedure to assess these types of EBV infections has been improved. In particular, real-time polymerase chain reaction (PCR) has been used to quantify the EBV load, and the MHC: peptide tetramer assay has been used to quantitate EBV-specific CTLs; these tests have been employed for the management of the illnesses associated with EBV infection. Here, we have reviewed the recent progress in the clinical application of these assays. The pathogenesis of EBV-infected T/NK cells, and the host immune response to infection, including the roles carried out by innate immunity and inflammatory cytokines, are likely to be revealed in the future.

14. Concomitant infection with exogenous mouse mammary tumor virus encoding I-E-dependent superantigen in I-E-negative mouse strain

Author

Yukio Ando, Wajjwalku W, Niimi N, Hiromatsu K, Morishima T, and Yoshikai Y

Subjects
Mice, Inbred BALB C, Superantigens, Base Sequence, Sequence Homology, Amino Acid, Virus Integration, Molecular Sequence Data, Immunology, Histocompatibility Antigens Class II, Polymerase Chain Reaction, Mice, Inbred C57BL, Mice, Tumor Virus Infections, Milk, Mammary Tumor Virus, Mouse, Mice, Inbred DBA, Pregnancy, DNA, Viral, Animals, Immunology and Allergy, Female, Amino Acid Sequence, Retroviridae Infections
Abstract

We found that milk from II TES mice contained two species of exogenous mouse mammary tumor viruses (MMTV). Sequence analysis of the open reading frame (ORF) in the MMTV 3' long terminal repeat indicated that the two MMTV, MMTV (II TES2) and MMTV (II TES14), encode superantigens specific for V beta 2+ T cells and V beta 14+ T cells, respectively. In an experiment of subcutaneous injection of II TES milk, both T cells bearing TCR V beta 2 and V beta 14 proliferated vigorously in the draining lymph node from BALB/c mice (H-2d I-E+), whereas only V beta 14+ T cells showed significant proliferation in C57BL/6 mouse (B6 H-2b I-E-) lymph nodes. These findings indicated that the superantigen encoded by MMTV (II TES2) required MHC class II I-E molecules exclusively for Ag presentation, but MMTV (II TES14) stimulated V beta 14+ T cells even in the absence of I-E molecules. Semiquantitative analysis of MMTV proviruses using PCR revealed that B6 mice were not infected with MMTV (II TES2) by injection of this MMTV alone. However, injection of II TES milk containing both MMTV (II TES14) and MMTV (II TES2) induced infection of B6 mice with MMTV (II TES2) besides MMTV (II TES14), in spite of no expansion of V beta 2+ T cells in this mouse strain. These results suggested that I-E-negative mice were concomitantly infected with MMTV (II TES2) with the help of I-E independent T cell activation mediated by MMTV (II TES14).

18. Discrete symmetry tests in neutron-induced compound states

Author

Shimizu, H. M., Snow, W. M., Gudkov, V. P., Bowman, J. D., Curole, J., Goodson, B. M., Harada, H., Hautle, P., Hino, M., Hirota, K., Go Ichikawa, Ino, T., Ishimoto, S., Iwata, T., Kimura, A., Kitaguchi, M., Kiyanagi, Y., Koga, J., Mishima, K., Miyachi, Y., Momose, T., Morishima, T., Nagamoto, K., Okada, A., Okudaira, T., Penttila, S., Plaster, B., Sakai, K., Schaper, D., Takada, S., Taketani, K., Tong, X., Tremsin, A. S., Yamagata, Y., Yamamoto, T., Yamanaka, N., Yokohashi, M., and Yoshioka, T.

19. Antigen-driven expansion and contraction of CD8(+)-activated T cells in primary EBV infection

Author

Hoshino, Y., Morishima, T., Hiroshi Kimura, Nishikawa, K., Tsurumi, T., and Kuzushima, K.

Subjects
Herpesvirus 4, Human, Histocompatibility Antigens Class I, Immunology, Epitopes, T-Lymphocyte, Cell Separation, Genome, Viral, HLA-DR Antigens, CD8-Positive T-Lymphocytes, Viral Load, Lymphocyte Activation, Interferon-gamma, Humans, Leukocyte Common Antigens, Immunology and Allergy, Infectious Mononucleosis, Antigens, Viral
Abstract

The origin of the increased numbers of CD8+ atypical lymphocytes, expressing activated markers such as HLA-DR or CD45RO, in the peripheral blood of patients with infectious mononucleosis (IM) has been debated. Using a recently developed assay to detect intracellular accumulation of IFN-γ in EBV-reactive T cells by FACS, we have demonstrated that 34–54% of HLA-DR+/CD8+ and 34–60% of CD45RO+/CD8+ T cells in the PBMCs of febrile patients suffering from IM are EBV-specific. The EBV-specific CD8+ T cell counts in the PBMCs of four febrile patients suffering from IM ranged between 2260 and 8200/μl, decreasing to 5.1% and 7.9% of the counts in the first samples over 10 days in two donors. The decline of CD8+ T cell subpopulations, namely HLA-DR+, CD45RO+, and EBV-specific T cells, was in parallel with the drop in the EBV genome load. These data indicate that the Ag-driven expansion of CD8+ T cells and subsequent contraction with the Ag decline in vivo in humans is effective for clearing virus-infected cells with minimal disturbance of the homeostasis of the immune system.

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