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5 results on '"Miraglia C"'

1. Nutrition and lipidomic profile in colorectal cancers

Author

Notarnicola, M., Caruso, M. G., Tutino, V., De Nunzio, V., Gigante, I., De Leonardis, G., Veronese, N., Rotolo, O., Reddavide, R., Stasi, E., Miraglia, C., Nouvenne, A., Meschi, T., De’ Angelis, G. L., Di Mario, F., Leandro, G., Notarnicola, M., Caruso, M.G., Tutino, V., De Nunzio, V., Gigante, I., De Leonardis, G., Veronese, N., Rotolo, O., Reddavide, R., Stasi, E., Miraglia, C., Nouvenne, A., Meschi, T., De’ Angelis, G.L., Di Mario, F., and Leandro, G.

Subjects
nutrition, colorectal cancer, lipidomic analysis, fatty acids, lipoproteins
Abstract

Background: Adherence to a healthy diet has been reported to be essential for the primary prevention of colorectal cancer, through a reduction of tissue inflammation, a low concentration of circulating lipoproteins and lower levels of serum cholesterol. Since an altered expression of the fatty acids pattern has been demonstrated to be a crucial event in colorectal carcinogenesis, lipidomic analysis is considered able to identify early diagnostic and prognostic biomarkers of complex diseases such as colorectal cancer. Methods: cell membrane fatty acid profile and serum lipoproteins pattern were evaluated by gas chromatography and electrophoresis method respectively. Results: There is a close association between diet and lipidomic profile in colorectal cancer, both in pre-clinical and clinical studies. A modified serum lipoproteins pattern has been demonstrated to be predominant in intestinal tumors. Conclusions: The study of fatty acids profile in cell membrane and the evaluation of serum lipoproteins subfractions could be useful to have an integrate vision on the interactions between lipids and the pathogenesis of colorectal cancer and to understand the mechanisms of action and the consequences of these interactions on human health status. (www.actabiomedica.it). © Mattioli 1885.

Published
2018

2. Effectiveness and Safety of Pylera® in Patients Infected by Helicobacter Pylori: A Multicenter, Retrospective, Real Life Study

Author

Tursi, A., Franceschi, M., Allegretta, L., Savarino, E., De Bastiani, R., Elisei, W., Baldassarre, G., Ferronato, A., Scida, S., Miraglia, C., Penna, A., Licci, C., Rizzo, G. L., Pranzo, G., Cassieri, C., Brandimarte, G., Picchio, M., and Di Mario, F.

Subjects
Male, Helicobacter pylori, Antibiotics, Bismuth-containing therapy, Safety, Treatment, Anti-Bacterial Agents, Bismuth, Demography, Drug Therapy, Combination, Endoscopy, Female, Helicobacter Infections, Humans, Metronidazole, Middle Aged, Organometallic Compounds, Retrospective Studies, Tetracycline, Treatment Outcome, Drug Therapy, Combination
Abstract

Our aims were to assess the real life effectiveness and safety of the new bismuth-containing quadruple therapy in a large population of patients infected by Helicobacter pylori.Consecutive dyspeptic H. pylori-positive patients were enrolled, both naïve for treatment and already unsuccessfully treated. Patients were treated with Pylera® 3 capsules 4 times/daily plus omeprazole 20 mg or esomeprazole 40 mg 2 times/daily for 10 days. Eradication was confirmed using a urea-breath test (at least 30 days after the end of the treatment). Efficacy and safety were assessed.A total of 349 patients were treated. H. pylori eradication was achieved in 316 (90.5%, 95% CIs 80.8-1.0) patients in the intention-to-treat population, and in 93.5% (95% CIs 83.5-1.0) in the per-protocol population. No difference in the eradication rate was found between naïve and previously treated patients (91.3 vs. 90.0%, p = 0.901). Adverse events occurred in 55 patients (15.8%, 95% CIs 11.9-20.1). Five patients discontinued treatment: 2 patients suffered from severe abdominal pain, one patient from headache, one patient from diarrhea, and one patient from diffuse urticarial rush.Pylera® achieved a remarkable eradication rate in real life both as first treatment and as a rescue therapy, with a good safety profile.

Published
2017

5. Sport (diritto dello)

Author

LIOTTA, Giuseppe, Martuccelli, S, Pescatore, V, Di Mauro, N, Dogliotti, M, Barenghi, A, Gambino, F, Majo, S, Bonilini, G, Parisi, F, Mastropaolo, F, Iudica, G, Criscuolo, F, Gallo, P, De Giorgi, M.V., Traisci, F.P., Gianola, A, Rizzi, A, Macioce, F, Lucchini Guastalla, E, Magri, G, Bembo, M.D., Pilia, C, Conte, G, De Meo, R, Troiano, S, Clarizia, R, Mattei, U, Carleo, R, Zoppini, A, Poletti, D, Ceccherini, G, Breccia, U, di Mauro, N, Lener, G, Pasquino, T, Mora, A, Petrone, M, Follieri, L, D'Alessandro, L, Salomone, D, Montinaro, R, Majello, U, Maggiolo, M, Moscarini, L.V., Biscontini, G, Tufarelli, M.R., Pannasilico, M, Villa, G, Gambino, A.M., Orlando, S, Spadafora, A, Venuti, M.C., Caterini E, Calabrò, L, Macario, F, Nicolussi, A, Francario, L, Sciascia, P, Grasso, B, Venosta, F, Polvani, G, Messinetti, D, Di Ciommo, F, Rizzo, F, Mazzamuto, S, Benedetti, A.M., Roppo, V, Nuzzo, M., Rossi Carleo, L., Gerbo, F., Mantovani, M., Costanza, M., Gianola, A., Marullo di Condojanni, S., Ponzanelli, G., Alessi, R., Modica, L., Palmerini, E., Urso, A., Ferrando, G., Ricci, F., Genovese, A., Scozzafava, T.O., Bozzi, G., Ruscello, F., Sirena, P., Renda, A., Maugeri, M.R., Martuccelli, S., Napoli, E.V., Leccese, E., Grisi, G., Bruscuglia, L., Scognamiglio, C., Romeo, F., Clarizia, R., Barba, V., Cicala, C., Benincasa, M., Galgano, F., Janes Carratù, F., Troisi, B., Barela, M., Di Amato, A., Piccinini, S., Federico, A., Stella, G., Venturelli, A., Sirgiovanni, B., Piccoli, P., Palmieri, A.M., Verdicchio, V., Gabrielli, E., Pilia, C., Genghini, I., Perchinunno, R., Ferri, G.B., Capaldo, G., Vocaturo, C., Marini, R., Riario Sforza, M., Tuccillo, R., Ricca, L., Alcaro, F., Duvia, P., Zaccaria, A., Veneziano, A., Cicconi, E., Basini, G.F., Oberto, G., Graziani, C.A., D'Angelo, A., Ferreri, S., Capobianco, E., Stanghellini, L., Tamponi, M., Rossi, A.M., Ambrosini, L., Bocchini, F., Sicchiero, G., Stanzione, P., Gardella Tedeschi, B., Minutillo Turtur, M., Carnevali, U., Zambrano, V., Sagna, A., D'Andrea, S., Gambino, F., Perlingieri, G., Gentili, A., Delfini, F., Smiroldo, A., De Cristofaro, G., Furgiuele, G., Zaccheo, M., Colavincenzo, D., Bianca, M., Andrini, M.C., Carboni, B., Merlino, P.E., De Sanctis Ricciardone, A., Magazzù, A., Figone, A., Baffi, E., Parisi, F., Proto, M., Liserre, A., Criaco, C., Minervini, E., Miraglia, C., Lupoi, M., Trimarchi, M., Marinelli, F., Velani, P., Rabitti, M., Luminoso, A., Del Prato, E., and Liotta, G

Subjects
ordinamento sportivo, prestazione sportiva, responsabilità nello sport, giustizia sportiva, Settore IUS/01 - Diritto Privato
Published
2011

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