1. Epstein-Barr virus BART microRNAs in EBV- associated Hodgkin lymphoma and gastric cancer
- Author
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De Re, V., Caggiari, L., De Zorzi, M., Fanotto, V., Miolo, G., Puglisi, F., Cannizzaro, R., Canzonieri, V., Steffan, A., Farruggia, P., Lopci, E., D'Amore, E. S. G., Burnelli, R., Mussolin, L., Mascarin, M., De Re, V., Caggiari, L., De Zorzi, M., Fanotto, V., Miolo, G., Puglisi, F., Cannizzaro, R., Canzonieri, V., Steffan, A., Farruggia, P., Lopci, E., D'Amore, E. S. G., Burnelli, R., Mussolin, L., and Mascarin, M.
- Subjects
Cancer Research ,Cell type ,Micro RNA ,Epidemiology ,HL ,Review ,medicine.disease_cause ,Gastric carcinoma cancer ,lcsh:RC254-282 ,lcsh:Infectious and parasitic diseases ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,EBV ,hemic and lymphatic diseases ,microRNA ,Hodgkin lymphoma ,GC ,Medicine ,Epstein-Barr virus ,lcsh:RC109-216 ,030304 developmental biology ,miRNA ,0303 health sciences ,Tumor microenvironment ,BamHI fragment a rightward transcript ,business.industry ,Autophagy ,Cancer ,Epstein-Barr viru ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Epstein–Barr virus ,Microvesicles ,Infectious Diseases ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,BART ,business - Abstract
Background EBV produces miRNAs with important functions in cancer growth, tumor invasion and host immune surveillance. The discovery of EBV miR-BARTs is recent, and most of their functions are still unknown. Nonetheless, some new studies underline their key roles in EBV-associated malignancies. Main body In EBV-associated tumors, the expression profile of miR-BARTs varies according to the cell type, autophagic process and signals received from the tumor microenvironment. By the same way of interest is the interaction between tumor cells and the tumor environment by the release of selected EBV miR-BARTs in addition to the tumor proteins trough tumor exosomes. Conclusion In this review, we discuss new findings regarding EBV miR-BARTs in Hodgkin lymphoma and gastric cancer. The recent discovery that miRNAs are released by exosomes, including miR-BARTs, highlights the importance of tumor and microenvironment interplay with more specific effects on the host immune response.
- Published
- 2020