14 results on '"Min-Hee Hwang"'
Search Results
2. 4-week dose range finding toxicity test of Magnoliae Flos extract in Sprague-Dawley rats
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Ju-Hyoung Park, Eun-Kyung Ahn, Kitae Park, Min Hee Hwang, Young-Rak Cho, Dong-Ryung Lee, Bong-Keun Choi, and Joa Sub Oh
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Organic Chemistry ,Bioengineering - Published
- 2022
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3. Development of Vivorium, a new indoor horticultural ornamental plants via plant tissue culture techniques
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In Sun Cho, Su Jung Kim, Hyun Sook Kwon, Sun-Hyung Kim, Min Hee Hwang, Mi Hyung Kim, Doyeon Kim, and Jong Bo Kim
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business.industry ,Plant tissue culture ,Ornamental plant ,Plant Science ,Biology ,business ,Agronomy and Crop Science ,Biotechnology - Published
- 2021
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4. Improvement of Obesity and Dyslipidemic Activity of Amomum tsao-ko in C57BL/6 Mice Fed a High-Carbohydrate Diet
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Wonsik Jeong, Joa Sub Oh, Eun-Kyung Ahn, Min Hee Hwang, Seung Hwan Yang, Young-Rak Cho, Dong-Wan Seo, Ju-Hyoung Park, Young-Jin Park, and H. Ko
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medicine.medical_specialty ,Normal diet ,Pharmaceutical Science ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,Amomum ,Analytical Chemistry ,lcsh:QD241-441 ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,lcsh:Organic chemistry ,Internal medicine ,Lipid droplet ,Drug Discovery ,Hyperlipidemia ,medicine ,Physical and Theoretical Chemistry ,antiobesity ,liver tissue ,biology ,Triglyceride ,business.industry ,Organic Chemistry ,Amomum tsao-ko ,biology.organism_classification ,medicine.disease ,Obesity ,Endocrinology ,chemistry ,Chemistry (miscellaneous) ,antidyslipidemia ,Molecular Medicine ,Zingiberaceae ,business ,Lipoprotein ,high-carbohydrate diet - Abstract
Amomum tsao-ko Crevost et Lemaire (Zingiberaceae) is a medicinal herb found in Southeast Asia that is used for the treatment of malaria, abdominal pain, dyspepsia, etc. The aim of this study was to investigate the effect of an ethanol extract of Amomum tsao-ko (EAT) on obesity and hyperlipidemia in C57BL/6 mice fed a high-carbohydrate diet (HCD). First, the mice were divided into five groups (n = 6/group) as follows: normal diet, HCD, and HCD+EAT (100, 200, and 400 mg/kg/day), which were orally administered with EAT daily for 84 days. Using microcomputed tomography (micro-CT) analysis, we found that EAT inhibited not only body-weight gain, but also visceral fat and subcutaneous fat accumulation. Histological analysis confirmed that EAT decreased the size of fat tissues. EAT consistently improved various indices, including plasma levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein, high-density lipoprotein, atherogenic index, and cardiac risk factors, which are related to dyslipidemia—a major risk factor for heart disease. The contents of TC and TG, as well as the lipid droplets of HCD-induced hepatic accumulation in the liver tissue, were suppressed by EAT. Taken together, these findings suggest the possibility of developing EAT as a therapeutic agent for improving HCD-induced obesity and hyperlipidemia.
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- 2021
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5. Improvement of Obesity and Dyslipidemic Activity of
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Ju-Hyoung, Park, Eun-Kyung, Ahn, Min Hee, Hwang, Young Jin, Park, Young-Rak, Cho, Hye-Jin, Ko, Wonsik, Jeong, Seung Hwan, Yang, Dong-Wan, Seo, and Joa Sub, Oh
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liver tissue ,Plants, Medicinal ,Plant Extracts ,Carbohydrates ,Amomum tsao-ko ,Article ,Diet ,Lipoproteins, LDL ,Mice, Inbred C57BL ,Mice ,Adipose Tissue ,Liver ,Zingiberaceae ,antidyslipidemia ,Animals ,Obesity ,antiobesity ,Amomum ,Triglycerides ,Dyslipidemias ,high-carbohydrate diet - Abstract
Amomum tsao-ko Crevost et Lemaire (Zingiberaceae) is a medicinal herb found in Southeast Asia that is used for the treatment of malaria, abdominal pain, dyspepsia, etc. The aim of this study was to investigate the effect of an ethanol extract of Amomum tsao-ko (EAT) on obesity and hyperlipidemia in C57BL/6 mice fed a high-carbohydrate diet (HCD). First, the mice were divided into five groups (n = 6/group) as follows: normal diet, HCD, and HCD+EAT (100, 200, and 400 mg/kg/day), which were orally administered with EAT daily for 84 days. Using microcomputed tomography (micro-CT) analysis, we found that EAT inhibited not only body-weight gain, but also visceral fat and subcutaneous fat accumulation. Histological analysis confirmed that EAT decreased the size of fat tissues. EAT consistently improved various indices, including plasma levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein, high-density lipoprotein, atherogenic index, and cardiac risk factors, which are related to dyslipidemia—a major risk factor for heart disease. The contents of TC and TG, as well as the lipid droplets of HCD-induced hepatic accumulation in the liver tissue, were suppressed by EAT. Taken together, these findings suggest the possibility of developing EAT as a therapeutic agent for improving HCD-induced obesity and hyperlipidemia.
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- 2021
6. Tracheal Glomus Tumor: A Case Report with CT Imaging Features
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Jeong-A Yeom, Yeon-Joo Jeong, Hyo-Yeong Ahn, Jung-Seop Eom, Chang-Hun Lee, and Min-Hee Hwang
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General Medicine - Abstract
Background and Objectives: Glomus tumors are rare benign tumors. The majority of them affect the skin the most and are rarer in the trachea, where the glomus bodies may not be present. Only scarce reports of tracheal glomus tumors have been reported solely with case reports of relevant articles. Materials and Methods: A 53-year-old man, with a free previous medial history, presented to our hospital with tracheal mass which was incidentally found. He did not complain of any specific symptoms associated with the tracheal tumor. The contrast-enhanced chest computed tomography (CT) revealed an avid enhancing nodular lesion, which is similar to blood vessels, in the trachea, 3 cm above the carina level without definite airway obstruction. Results: Successful tracheal resection and end-to-end anastomosis were performed on the patients; therefore, the final post-operative pathologic findings revealed a benign tracheal glomus tumor. The follow-up CT scan four months after operation showed complete removal of the tumor. Conclusion: Tracheal glomus tumors, even rare entities, could be considered as a differential diagnosis if a highly enhancing mass appears on CT images.
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- 2022
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7. Spiraea prunifolia leaves extract inhibits adipogenesis and lipogenesis by promoting β-oxidation in high fat diet-induced obese mice
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Ju-Hyoung, Park, Eun-Kyung, Ahn, Hye-Jin, Ko, Min Hee, Hwang, Young-Rak, Cho, Dong-Ryung, Lee, Bong-Keun, Choi, Dong-Wan, Seo, and Joa Sub, Oh
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Pharmacology ,Adipogenesis ,Plant Extracts ,Lipogenesis ,Mice, Obese ,General Medicine ,AMP-Activated Protein Kinases ,Diet, High-Fat ,Mice, Inbred C57BL ,Plant Leaves ,Mice ,Cholesterol ,Animals ,Anti-Obesity Agents ,Obesity ,Spiraea - Abstract
Spiraea prunifolia has been used in Korean traditional medicine to treat malaria, fever, and emetic conditions. Previous investigation reported that several parts of Spiraea prunifolia show various functional effects. However, the effect of Spiraea prunifolia leaves extract (SPE) on anti-obesity remains unclear. Therefore, we used a high-fat diet (HFD)-induced obese mouse model in this study to investigate the effects of SPE on adipogenesis, lipogenesis, and β-oxidation. Oral administration of SPE in HFD-induced obese mice considerably reduced body weight, serum levels such as total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol, adipose tissue weight, and adipocyte cell size. Moreover, SPE significantly decreased protein expression levels of adipogenesis and lipogenesis related genes such as CCAAT/enhancer binding protein α, peroxisome proliferator-activated receptor γ, adipocyte protein 2, acetyl-CoA carboxylase, and fatty acid synthase in epididymal adipose tissues. SPE treatment induced the protein expression of carnitine palmitoyl transferase-1, which might have promoted phosphorylated AMP-activated protein kinase-medicated β-oxidation. The present study reveals an anti-adipogenic, anti-lipogenic, β-oxidation effects of SPE in vivo and represents AMP-activated protein kinase signaling as targets for SPE.
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- 2022
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8. Combretum quadrangulare Extract Attenuates Atopic Dermatitis-Like Skin Lesions through Modulation of MAPK Signaling in BALB/c Mice
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Jae-Shin Kang, Joa Sub Oh, Young-Rak Cho, Seong Su Hong, Seung Hwan Yang, Min Hee Hwang, Dong-Wan Seo, Ju-Hyoung Park, Kim Won Hee, and Eun-Kyung Ahn
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Chemokine ,Thymic stromal lymphopoietin ,mitogen-activated protein kinase ,Pharmaceutical Science ,skin lesions ,Pharmacology ,Immunoglobulin E ,Article ,Analytical Chemistry ,BALB/c ,lcsh:QD241-441 ,03 medical and health sciences ,0302 clinical medicine ,lcsh:Organic chemistry ,Drug Discovery ,medicine ,Combretum quadrangulare ,Physical and Theoretical Chemistry ,030304 developmental biology ,0303 health sciences ,biology ,atopic dermatitis ,business.industry ,Organic Chemistry ,Interleukin ,Atopic dermatitis ,Ceramidase ,biology.organism_classification ,medicine.disease ,Chemistry (miscellaneous) ,inflammation ,030220 oncology & carcinogenesis ,biology.protein ,Molecular Medicine ,business - Abstract
Atopic dermatitis (AD) is a chronic inflammatory disease. Combretum quadrangulare (C. quadrangulare) is used as a traditional medicine to improve various pathologies in Southeast Asia. In this study, we investigated the effects of C. quadrangulare ethanol extract (CQ) on 1-chloro-2,4-dinitrobenzene (DNCB)-induced AD like skin lesions in BALB/c mice. After administration with CQ (100, 200, and 400 mg/kg) for 6 weeks, AD symptoms, protein expression, immunoglobulin E (IgE), thymus and activation-regulated chemokine (TARC), and ceramidase level were measured in skin lesions of DNCB-induced BALB/c mice. CQ group improved the dermatitis score, skin pH, transepidermal water loss (TEWL), and skin hydration. Furthermore, histological analysis revealed that CQ attenuated the increased epidermal thickness and infiltration of mast cells caused by DNCB. CQ also increased the expression of filaggrin, and reduced the expression of ceramidase, serum IgE level, and the number of eosinophils. CQ effectively inhibited cytokines and chemokines such as interleukin (IL)-6, IL-13, TARC, and thymic stromal lymphopoietin (TSLP) at the mRNA levels, as well as the activation of mitogen-activated protein kinase (MAPK), including extracellular signal-regulated kinase (ERK), c-jun N-terminal kinase (JNK), and p38 in the skin lesions. Taken together, these findings demonstrate that CQ may be an effective treatment of AD-like skin lesions by inhibiting the expression of inflammatory mediators via the MAPK signaling pathways.
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- 2020
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9. Single and repeated oral dose toxicity tests of saline groundwater in ICR mice
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Namhyun Chung, Eun Byeol Go, Miju Cho, Young Sig Park, Min Hee Hwang, Mindong Lee, Dong Gun Lee, and Hyeri Lee
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0106 biological sciences ,0301 basic medicine ,Oral dose ,medicine.medical_specialty ,Chemistry ,Organic Chemistry ,Physiology ,Saline water ,01 natural sciences ,General Biochemistry, Genetics and Molecular Biology ,Single oral dose ,Toxicology ,03 medical and health sciences ,030104 developmental biology ,010608 biotechnology ,Toxicity ,medicine ,Seawater ,Histopathology ,Saline groundwater ,Icr mice - Abstract
Saline groundwater (SGW) is the underground saline water obtained from basalt layer through which seawater has infiltrated. SGW contains more than 10,000 mg/L dissolved salt solid, the value of which is less than that of seawater. As part of its safety test, single and repeated oral dose toxicity tests were conducted with male and female ICR mice for 14 days. In single oral dose test with dosage of 10, 30, and 50 mL/kg, no gross changes in appearance or mortality were observed. In repeated oral dose test with dosage of 8, 14, and 20 mL/kg, no significant changes in mortality or weights of body and organ were observed. Additional analysis of serum biochemical parameter and histopathology also indicated no meaningful change during the tests. When taken all together, these results show that no toxicity of SGW could be found with single and repeated toxicity tests. However, for final conclusion of safety, further toxicity studies need to be performed with animal and human subjects.
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- 2017
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10. Differential induction of allergy responses by low molecular weight wheat proteins from six wheat cultivars
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Young Keun Cheong, Miju Cho, Chon Sik Kang, Min Hee Hwang, Hyeri Lee, Nam Taek Lee, and Namhyun Chung
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0301 basic medicine ,Allergy ,Gastrointestinal tract ,Histamine secretion ,Chemistry ,Organic Chemistry ,food and beverages ,Bioengineering ,medicine.disease ,Serum ige ,03 medical and health sciences ,030104 developmental biology ,Agronomy ,Antigen ,medicine ,Cultivar ,Food science ,Wheat allergy ,Anaphylaxis - Abstract
Although wheat is a common staple food in the world, some people suffer from a variety of wheat allergies. For example, wheat-dependent exercise-induced anaphylaxis is induced in the gastrointestinal tract by wheat proteins. Relatively high molecular weight proteins that are salt-insoluble induce many wheat allergies. In the present study, we investigated the induction of an allergy response using crude wheat proteins, which are relatively low molecular weight, salt-soluble proteins. The crude antigen used in this study was extracted using phosphate buffered saline. When the antigen extracts from various wheat cultivars were orally administered, differentiable degrees of allergy responses were observed as measured by serum IgE and histamine secretion compared to the control. Serum IgE levels increased following administration of three of the wheat extracts. This evidence suggests that a combination of salt-soluble wheat proteins could be antigens for the induction of various allergy responses.
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- 2017
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11. Anti-diabetic effect of magnesium salt extracts from deep-sea water in C57BLKS/J-db/db mice
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Dong Gun Lee, Eun Byeol Go, Namhyun Chung, Young Sig Park, Miju Cho, and Min Hee Hwang
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0301 basic medicine ,medicine.medical_specialty ,business.industry ,Magnesium ,Potassium ,Organic Chemistry ,Type 2 Diabetes Mellitus ,chemistry.chemical_element ,Magnesium salt ,Type 2 diabetes ,Calcium ,medicine.disease ,Impaired fasting glucose ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Endocrinology ,chemistry ,Diabetes mellitus ,Internal medicine ,medicine ,030212 general & internal medicine ,business - Abstract
Recently, the incidence of diabetes has increased steadily worldwide. Type 2 diabetes constitutes about 90% of all cases of diabetes, and it is associated with many complications. Currently, the drugs for therapy of type 2 diabetes are considerably limited owing to disadvantages such as side effects and high rate of secondary failure. To overcome these problems, it is necessary to develop effective therapeutic agents from safe natural products. Deep-sea water (DSW) is abundant in minerals such as potassium (K), calcium (Ca), and magnesium (Mg). Mg supplements are known for their usefulness in the treatment of type 2 diabetes. In this study, we examined the anti-diabetic effect of Mg salt extracts from DSW in a diabetic mouse model. We observed that the groups treated with Mg salt extract showed better response toward fasting blood glucose level and oral glucose tolerance test when compared to the positive control. Overall, the Mg salt extract improved the symptoms of impaired fasting glucose and glucose tolerance, suggesting that it can be used as an effective agent for the treatment of type 2 diabetes mellitus.
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- 2017
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12. Comparison of blood glucose levels and allergic responses on treatment with six wheat cultivars
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Nam Taek Lee, Dong Gun Lee, Eun Byeol Go, Hyeri Lee, Young Keun Cheong, Miju Cho, Namhyun Chung, Chon Sik Kang, and Min Hee Hwang
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0106 biological sciences ,0301 basic medicine ,Allergy ,medicine.disease_cause ,Immunoglobulin E ,01 natural sciences ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,chemistry.chemical_compound ,Glutenin ,medicine ,Cultivar ,Food science ,biology ,Organic Chemistry ,food and beverages ,medicine.disease ,Indigestion ,030104 developmental biology ,chemistry ,Agronomy ,Allergic response ,biology.protein ,Composition (visual arts) ,medicine.symptom ,Histamine ,010606 plant biology & botany - Abstract
Allergies and indigestion problems have increased in our society with increasing wheat consumption. Among wheat proteins, omega-5 gliadins (ω5-gliadins) and high molecular weight (HMW)-glutenin are known to be some of the major factors responsible for an allergic response and indigestion. Certain low molecular weight (LMW)-glutenin subunits are also able to promote local inflammation, and share common epitopes with ω5-gliadins. It is known that different wheat cultivars have different combinations of HMW- and LMW-glutenins. We investigated the relationship between the composition of LMW-glutenins and the degree of allergic response or indigestion. The extent of allergic reaction and indigestion characteristics in response to six different wheat cultivars were compared. Patterns of the change of blood glucose level with time, which were employed to measure the indigestion, were quite different, depending on the type of wheat cultivars. The extent of allergic response, as measured with the histamine and IgE levels, was also quite different, depending on the type of wheat cultivars. In addition, the extents were not correlated with patterns of LMW-glutenin DNA and HMW/LMW glutenin protein of various wheat cultivars. The results from the present study suggest that some more other factors, together with factors studied above, need to be considered to better explain the physiological phenomena of variation in blood glucose level and allergic response.
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- 2016
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13. Single- and repeated-dose oral toxicity tests of deep sea water mineral extracts in ICR mice
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Young Sig Park, Min Hee Hwang, Eun Byeol Go, Dong Gun Lee, Namhyun Chung, and Miju Cho
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0301 basic medicine ,medicine.medical_specialty ,Food intake ,Chemistry ,Organic Chemistry ,Radiochemistry ,Mineral deficiency ,Physiology ,chemistry.chemical_element ,Bioengineering ,010501 environmental sciences ,Calcium ,medicine.disease ,01 natural sciences ,03 medical and health sciences ,030104 developmental biology ,Oral administration ,Toxicity ,medicine ,Histopathology ,Oral toxicity ,Icr mice ,0105 earth and related environmental sciences - Abstract
Deep sea water (DSW) is located 100 to 500 m below the sea surface. DSW is widely used in various fields, and is an important source of minerals that can be used to treat mineral deficiency. In the present study, the oral toxicity of DSW-mineral extracts was determined using single-dose and 14-day repeated dose oral toxicity tests in ICR mice. For the single-dose oral toxicity tests, mineral extracts of magnesium (Mg) and calcium (Ca) at doses of 0, 6, 270, 810, and 1,350 mg/kg, respectively, were orally administered to mice once at the beginning of the experiment, and the mice were observed for 14 days. For the 14- day repeated dose oral toxicity tests, Mg and Ca mineral extracts at doses of 0, 3, 135, 405, 675 mg/kg, respectively, were orally administered to mice daily, and the mice were observed for 14 days. Various tests were performed including visual observation; analysis of relative organ weight, food intake, and organ weight; biochemical analysis, and histopathology. The results indicated that mortality and changes in appearance were not observed among differentially administered groups of male and female ICR mice during the experimental period. Differences in body weight gain, food intake, organ weight, and histopathology parameters were not significant between the control and mineral-administered groups. Some results of the biochemical analyses were significantly different, but showed no specific tendencies. Overall, no evidence of toxicity was observed from the oral administration of DSW extracts of Ca and Mg in ICR mice.
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- 2016
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14. Erratum to: Single- and repeated-dose oral toxicity tests of deep sea water mineral extracts in ICR mice
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Eun Byeol Go, Dong Gun Lee, Young Sig Park, Min Hee Hwang, Namhyun Chung, and Miju Cho
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Mineral ,Chemistry ,Organic Chemistry ,Radiochemistry ,Bioengineering ,Oral toxicity ,Deep sea ,Icr mice - Published
- 2016
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