Search

Your search keyword '"Melissa Nyendak"' showing total 122 results
Start Over Author "Melissa Nyendak" Database OpenAIRE
122 results on '"Melissa Nyendak"'

1. Delving deeper

Author

Joel R. Burnett, Melissa Nyendak, Lawrence M. Tierney, Ndidi Unaka, Peter Stenzel, Sima S. Desai, and Alan J. Hunter

Subjects
Leadership and Management, Health Policy, Fundamentals and skills, General Medicine, Assessment and Diagnosis, Care Planning
Published
2021

2. Building communities of practice through case-based e-learning to prevent and manage TB among people living with HIV–India

Author

Reshu Agarwal, Upasna Agarwal, Chinmoyee Das, Ramesh Allam Reddy, Rashmi Pant, Christine Ho, B. Ravi Kumar, Vandana Dabla, Patrick K. Moonan, Melissa Nyendak, Sunil Anand, Anoop Kumar Puri, Sanjay K. Mattoo, Kuldeep Singh Sachdeva, Vijay V. Yeldandi, and Rohit Sarin

Subjects
Infectious Diseases
Abstract

Background Co-management of HIV-TB coinfection remains a challenge globally. Addressing TB among people living with HIV (PLHIV) is a key priority for the Government of India (GoI). In 2016, GoI implemented single-window services to prevent and manage TB in PLHIV. To strengthen HIV-TB service delivery, case-based e-learning was introduced to health care providers at Antiretroviral Therapy centres (ARTc). Methods We implemented a hub and spoke model to deliver biweekly, virtual, case-based e-learning at select ARTc (n = 115), from four states of India–Delhi, Uttar Pradesh, Andhra Pradesh and Tamil Nadu. We evaluated feasibility and acceptability of case-based e-learning and its impact on professional satisfaction, self-efficacy, knowledge retention using baseline and completion surveys, session feedback, pre-and post-session assessments. We reviewed routine programmatic data and patient outcomes to assess practices among participating ARTc. Results Between May 2018 and September 2020, 59 sessions were conducted with mean participation of 55 spokes and 152 participants. For 95% and 88% of sessions ≥ 80% of respondents agreed that topics were clear and relevant to practice, and duration of session was appropriate, respectively. Session participants significantly improved in perceived knowledge, skills and competencies (+ 8.6%; p = 0.025), and technical knowledge (+ 18.3%; p = 0.04) from baseline. Participating ARTc increased TB screening (+ 4.2%, p Conclusion Case-based e-learning is an acceptable and effective modus of capacity building and developing communities of practice to strengthen integrated care. E-learning could address demand for accessible and sustainable continuing professional education to manage complex diseases, and thereby enhance health equity. We recommend expansion of this initiative across the country for management of co-morbidities as well as other communicable and non-communicable diseases to augment the existing capacity building interventions by provide continued learning and routine mentorship through communities of practice.

Published
2022

3. Utility of the lateral flow urine lipoarabinomannan tuberculosis assay in patients with advanced HIV disease at antiretroviral therapy centres in Mumbai, India

Author

Shrikala Acharya, Prashant Deshpande, Edwin Sam Asirvatham, Amol Palkar, Charishma Jones Sarman, Chinmay Laxmeshwar, Maninder Singh Setia, Dhirubhai Rathod, Sagar Koli, Jayesh Dale, Vijay Yeldandi, Ramesh Allam, Reshu Agarwal, Sanjeev Verma, Sunita Upadhyaya, and Melissa Nyendak

Subjects
Adult, Lipopolysaccharides, Male, Cross-Sectional Studies, Multidisciplinary, Humans, India, Tuberculosis, Female, HIV Infections, Sensitivity and Specificity
Abstract

Background People with Advanced HIV Disease (AHD) are at higher risk of TB coinfection and mortality. However, there are challenges in TB diagnosis with the currently recommended diagnostic tools. WHO recommends lateral flow urine lipoarabinomannan (LF-LAM) assay to assist TB diagnosis among AHD patients. We assessed the utility and acceptability of using urine LF-LAM assay for TB diagnosis among patients at public Antiretroviral Therapy (ART) Centres in Mumbai. Methods The cross-sectional study was conducted among adult AHD patients accessing care from 17 ART centres during November,2020-June, 2021. Urine LF-LAM was offered as routine care for eligible patients in combination with standard diagnostic tests. We calculated the proportion of positive LF-LAM results by CD4 categories and TB symptoms and performed multivariable logistic regression to determine the factors associated with LF-LAM positivity. Results Among 2,390 patients, the majority (74.5%) had CD4 between 101–200 cells/mm3. The mean age was 43.7 years (SD:10.6), 68.6% were male, 8.4% had TB symptoms and 88.0% were on ART. The overall proportion of patients with urine LF-LAM positive results was 6.4%. Among PLHIV with CD4≤100 cells/mm3, the positivity was 43.0% and 7.7% in symptomatic and asymptomatic patients, respectively. Among PLHIV with a CD4>100 cells/mm3, the positivity was 26.7% and 2.7% in symptomatic and asymptomatic patients respectively. Urine LF-LAM positivity was higher among inpatients, ART naïve, patients on treatment for Conclusion The study demonstrated the utility of urine LF-LAM for TB diagnosis among AHD patients and the simple, user-friendly test was acceptable as part of routine care. Inclusion of urine LF-LAM test in the current diagnostic algorithm may facilitate early TB diagnosis among AHD patients.

Published
2022

4. Comprehensive definition of human immunodominant CD8 antigens in tuberculosis

Author

Meghan E. Cansler, Guanming Wu, David R. Sherman, Keith A. Chervenak, Kristi Guinn, W. Henry Boom, Deborah A. Lewinsohn, Shannon K. McWeeney, David M. Lewinsohn, Tomi Mori, Byung Park, LaShaunda L. Malone, Melissa Nyendak, Harriet Mayanja-Kizza, Sarah Zalwango, Gwendolyn Swarbrick, Joy Baseke, Katelynne Gardner Toren, and Megan D. Null

Subjects
0301 basic medicine, Modified vaccinia Ankara, Tuberculosis, Immunology, Article, Microbiology, Mycobacterium tuberculosis, 03 medical and health sciences, 0302 clinical medicine, Antigen, medicine, Pharmacology (medical), RC254-282, Pharmacology, biology, Latent tuberculosis, ELISPOT, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC581-607, medicine.disease, biology.organism_classification, Virology, 3. Good health, 030104 developmental biology, Infectious Diseases, Immunologic diseases. Allergy, Tuberculosis vaccines, 030215 immunology, Mycobacterium
Abstract

Despite widespread use of the Bacillus Calmette-Guerin vaccine, tuberculosis, caused by infection with Mycobacterium tuberculosis, remains a leading cause of morbidity and mortality worldwide. As CD8+ T cells are critical to tuberculosis host defense and a phase 2b vaccine trial of modified vaccinia Ankara expressing Ag85a that failed to demonstrate efficacy, also failed to induce a CD8+ T cell response, an effective tuberculosis vaccine may need to induce CD8+ T cells. However, little is known about CD8, as compared to CD4, antigens in tuberculosis. Herein, we report the results of the first ever HLA allele independent genome-wide CD8 antigen discovery program. Using CD8+ T cells derived from humans with latent tuberculosis infection or tuberculosis and an interferon-γ ELISPOT assay, we screened a synthetic peptide library representing 10% of the Mycobacterium tuberculosis proteome, selected to be enriched for Mycobacterium tuberculosis antigens. We defined a set of immunodominant CD8 antigens including part or all of 74 Mycobacterium tuberculosis proteins, only 16 of which are previously known CD8 antigens. Immunogenicity was associated with the degree of expression of mRNA and protein. Immunodominant antigens were enriched in cell wall proteins with preferential recognition of Esx protein family members, and within proteins comprising the Mycobacterium tuberculosis secretome. A validation study of immunodominant antigens demonstrated that these antigens were strongly recognized in Mycobacterium tuberculosis-infected individuals from a tuberculosis endemic region in Africa. The tuberculosis vaccine field will likely benefit from this greatly increased known repertoire of CD8 immunodominant antigens and definition of properties of Mycobacterium tuberculosis proteins important for CD8 antigenicity., Tuberculosis: Defining the proteins that drive immune responses Specific bacterial proteins have been found that drive effective immune responses to tuberculosis, with use in making more effective vaccines. Immunity to tuberculosis (TB) is facilitated by two types of white blood cell; however, most research has focused on one: the CD4+ T cell. Deborah A. Lewinsohn and David Lewinsohn, of the Oregon Health & Science University, USA, and collaborators lay out the essential functions of the oft-neglected CD8+ T cell, and undertook a broad approach to catalogue and define the bacterial proteins that activate the CD8+ T cell response. The team found that TB-infected humans reacted strongly to their protein library, and described several characteristics of CD8+ T cell ‘antigens’ (activators of immune cells) that will likely prove highly useful in the design of more protective TB vaccines.

Published
2017

5. Implementation of the Treat All Policy Among Persons with HIV Infection Enrolled in Care But Not on Antiretroviral Therapy - India, May 2017-June 2018

Author

Tedd V. Ellerbrock, Ramkrishn Gupta, Praveen Kumar, Manish Bamrotiya, Pramod Deoraj, Sukarma Tanwar, Ramesh Reddy Allam, Ramesam Ganti, Melissa Nyendak, Rajendra Prasad, Priya Kannan, Anwar Parvez, Shashikant Todmal, Padmaja Keskar, Reshu Agarwal, Srilatha Sivalenka, Malay Shah, Kiren Mitruka, Timothy H. Holtz, Nalini Chava, Ajit Rao, Uma Devi, and Shrikala Acharya

Subjects
medicine.medical_specialty, Health (social science), Epidemiology, Anti-HIV Agents, Health, Toxicology and Mutagenesis, Art initiation, Human immunodeficiency virus (HIV), India, HIV Infections, 030204 cardiovascular system & hematology, medicine.disease_cause, World Health Organization, World health, 03 medical and health sciences, 0302 clinical medicine, Health Information Management, Acquired immunodeficiency syndrome (AIDS), medicine, Humans, Full Report, 030212 general & internal medicine, Hiv treatment, Hiv transmission, business.industry, Health Policy, Emergency plan, General Medicine, medicine.disease, Antiretroviral therapy, CD4 Lymphocyte Count, Family medicine, business, Delivery of Health Care
Abstract

Since September 2015, the World Health Organization has recommended antiretroviral therapy (ART) for all persons with human immunodeficiency virus (HIV) infection, regardless of clinical stage or CD4 count (1). This Treat All policy was based on evidence that ART initiation early in HIV infection as opposed to waiting for the CD4 count to decline to certain levels (e.g.

Published
2019

6. Recognition of CD8+ T-cell epitopes to identify adults with pulmonary tuberculosis

Author

Melissa Nyendak, Emily Lenore Goldman Heaphy, Keith A. Chervenak, Gwendolyn Swarbrick, Christina Lancioni, Harriet Mayanja-Kizza, La Shaunda L. Malone, Rowan B. Duncan, Deborah A. Lewinsohn, Megan D. Null, Meghan E. Cansler, Byung Park, Mary Nsereko, David M. Lewinsohn, Joy Baseke, and W. Henry Boom

Subjects
Pulmonary and Respiratory Medicine, Download, Epitopes, T-Lymphocyte, CD8-Positive T-Lymphocytes, Criminology, Article, Interferon-gamma, 03 medical and health sciences, 0302 clinical medicine, Pulmonary tuberculosis, Nothing, Humans, Medicine, 030212 general & internal medicine, Tuberculosis, Pulmonary, Antigens, Bacterial, HLA-A Antigens, business.industry, Conflict of interest, Mycobacterium tuberculosis, Test (assessment), 030228 respiratory system, Financial interest, business, Pulmonary tb, Production team
Abstract

Tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb), remains a leading cause of morbidity and mortality. Current tools to identify Mtb-infected individuals, specifically interferon-gamma-release-assays (IGRAs) and the Tuberculin-skin test (TST), cannot distinguish between asymptomatic Mtb-infected individuals (latent Mtb infection/LTBI) and those with TB [1]. Advancement of TB diagnostics and their application in TB-endemic settings requires an assay that distinguishes between individuals with LTBI and TB. In this pilot study, we compared the ability of three CD8+ T cell-based assays to distinguish Ugandan adults with: confirmed pulmonary TB (HIV-uninfected and HIV-infected), LTBI (HIV-uninfected only), and those who are TST-negative (HIV-uninfected only). Footnotes This manuscript has recently been accepted for publication in the European Respiratory Journal . It is published here in its accepted form prior to copyediting and typesetting by our production team. After these production processes are complete and the authors have approved the resulting proofs, the article will move to the latest issue of the ERJ online. Please open or download the PDF to view this article. Conflict of interest: Dr. Lancioni has nothing to disclose. Conflict of interest: Dr. Mayanja-Kizza has nothing to disclose. Conflict of interest: Dr. Heaphy has nothing to disclose. Conflict of interest: Dr. Nyendak reports other from ViTi, Inc., outside the submitted work; Required language from OHSU: OHSU and Drs. David Lewinsohn, Deborah Lewinsohn, and Melissa Nyendak have a financial interest in, and Ms. Cansler, Ms. Null, and Ms. Swarbrick are employees of, ViTi, a company that may have a commercial interest in the results of this research and technology. These potential individual and institutional conflicts of interest have been reviewed and managed by OHSU. Conflict of interest: Ms. Malone has nothing to disclose. Conflict of interest: Dr. NSEREKO has nothing to disclose. Conflict of interest: Ms. Null reports other from Viti, Inc, outside the submitted work. Conflict of interest: Dr. Park has nothing to disclose. Conflict of interest: Mrs. Swarbrick reports other from ViTi, inc, outside the submitted work. Conflict of interest: Ms. Duncan has nothing to disclose. Conflict of interest: Dr. Boom reports grants from NIH/NIAID, during the conduct of the study. Conflict of interest: Automatically generated: Dr. Lewinsohn reports grants from NIH, grants from NIH, other from Pape Family Research Institute, during the conduct of the study; other from ViTi Inc., outside the submitted work. Required language from OHSU: OHSU and Drs. David Lewinsohn, Deborah Lewinsohn, and Melissa Nyendak have a financial interest in, and Ms. Cansler, Ms. Null, and Ms. Swarbrick are employees of, ViTi, a company that may have a commercial interest in the results of this research and technology. These potential individual and institutional conflicts of interest have been reviewed and managed by OHSU. Conflict of interest: Ms. Baseke has nothing to disclose. Conflict of interest: Mr. Chervenak has nothing to disclose. Conflict of interest: Ms. Cansler reports other from Viti, Inc, outside the submitted work. Conflict of interest: Automatically generated: Dr. Lewinsohn reports grants from NIH, grants from NIH, other from Pape Family Research Institute, during the conduct of the study; other from ViTi Inc., outside the submitted work. Required language from OHSU: OHSU and Drs. David Lewinsohn, Deborah Lewinsohn, and Melissa Nyendak have a financial interest in, and Ms. Cansler, Ms. Null, and Ms. Swarbrick are employees of, ViTi, a company that may have a commercial interest in the results of this research and technology. These potential individual and institutional conflicts of interest have been reviewed and managed by OHSU.

Published
2019

7. Adenovirally-Induced Polyfunctional T Cells Do Not Necessarily Recognize the Infected Target: Lessons from a Phase I Trial of the AERAS-402 Vaccine

Author

Lewellys F. Barker, Amanda Duncan, Jerald C. Sadoff, Maria Grazia Pau, Thomas J. Evans, Deborah A. Lewinsohn, Ervina Winata Huff, Gretta L Blatner, Melissa Nyendak, Macaya Douoguih, Meghan E. Cansler, David M. Lewinsohn, Gwendolyn Swarbrick, and David A. Hokey

Subjects
0301 basic medicine, Serotype, Adult, CD4-Positive T-Lymphocytes, Male, T cell, Cell, CD8-Positive T-Lymphocytes, Article, Mycobacterium tuberculosis, 03 medical and health sciences, Young Adult, Immune system, Antigen, Double-Blind Method, medicine, Vaccines, DNA, Humans, Tuberculosis Vaccines, Multidisciplinary, biology, business.industry, Vaccination, biology.organism_classification, Virology, 3. Good health, 030104 developmental biology, medicine.anatomical_structure, Female, business, CD8
Abstract

The development of a vaccine for Mycobacterium tuberculosis (Mtb) has been impeded by the absence of correlates of protective immunity. One correlate would be the ability of cells induced by vaccination to recognize the Mtb-infected cell. AERAS-402 is a replication-deficient serotype 35 adenovirus containing DNA expressing a fusion protein of Mtb antigens 85A, 85B and TB10.4. We undertook a phase I double-blind, randomized placebo controlled trial of vaccination with AERAS-402 following BCG. Analysis of the vaccine-induced immune response revealed strong antigen-specific polyfunctional CD4+ and CD8+ T cell responses. However, analysis of the vaccine-induced CD8+ T cells revealed that in many instances these cells did not recognize the Mtb-infected cell. Our findings highlight the measurement of vaccine-induced, polyfunctional T cells may not reflect the extent or degree to which these cells are capable of identifying the Mtb-infected cell and correspondingly, the value of detailed experimental medicine studies early in vaccine development.

Published
2016

8. Interferon-γ Release Assays for Diagnosing Mycobacterium tuberculosis Infection in Renal Dialysis Patients

Author

Deborah A. Lewinsohn, Helene M. Calvet, Carol Johnson, Gerald H. Mazurek, Melissa Nyendak, Kevin L. Winthrop, David M. Lewinsohn, Gwendolyn Swarbrick, Peter Oh, and Melanie Lo

Subjects
Adult, Male, medicine.medical_specialty, Tuberculosis, Adolescent, Epidemiology, medicine.medical_treatment, Tuberculin, Enzyme-Linked Immunosorbent Assay, Critical Care and Intensive Care Medicine, Sensitivity and Specificity, Mycobacterium tuberculosis, Interferon-gamma, Bacterial Proteins, Tuberculosis diagnosis, Predictive Value of Tests, Renal Dialysis, Internal medicine, Diagnosis, medicine, Humans, Lymphocytes, Prospective Studies, Prospective cohort study, Aged, Aged, 80 and over, Antigens, Bacterial, Transplantation, biology, Tuberculin Test, business.industry, ELISPOT, Reproducibility of Results, Middle Aged, bacterial infections and mycoses, biology.organism_classification, medicine.disease, Nephrology, Predictive value of tests, Immunology, Kidney Failure, Chronic, Female, Reagent Kits, Diagnostic, Hemodialysis, business
Abstract

Background and objectives: End-stage renal disease (ESRD) patients are at high risk for tuberculosis (TB). IFN-γ release assays that assess immune responses to specific TB antigens offer potential advantages over tuberculin skin testing (TST) in screening such patients for Mycobacterium tuberculosis infection. This study sought to determine whether IFN-γ release assay results are more closely associated with recent TB exposure than TST results. Design, setting, participants, and measures: Prospective cohort investigation of patients at a hemodialysis center with a smear-positive case of TB. Patients without a history of TB underwent initial and repeat testing with TST, and with the IFN-γ assays QuantiFERON-TB Gold® (QFT-G) and ELISPOT test. Outcome measures included the prevalence of positive test results, identification of factors associated with positive results, and test result discordance. Results: A total of 100 (47% foreign born; median age, 55 yr; age range, 18 to 83 yr) of 124 eligible patients were enrolled. Twenty-six persons had positive TST results, 21 had positive QFT-G results, and 27 had positive ELISPOT results. Patients with TB case contact were likely to have a positive QFT-G result (P = 0.02) and ELISPOT results (P = 0.04), whereas TB case contact was not associated with positive TST results (P = 0.7). Positive TST results were associated with foreign birth (P = 0.04) and having had a TST in the previous year (P = 0.04). Conclusions: Positive IFN-γ assay results were more closely associated with recent TB exposure than were positive TST results. QFT-G and ELISPOT might offer a better method for detecting TB infection in ESRD patients.

Published
2008

9. Long-Term Testosterone Replacement Therapy (TRT) Use in HIV Patients and New Cardiovascular Events (CVE)

Author

Jwan Mohammadi, Rahwa Ghebremichael, Melissa Nyendak, and Graeme N. Forrest

Subjects
medicine.medical_specialty, business.industry, Logistic regression, medicine.disease, Surgery, Infectious Diseases, Oncology, Abacavir, Statistical significance, Chart review, Internal medicine, Hyperlipidemia, Hiv patients, medicine, Testosterone replacement, Adverse effect, business, medicine.drug
Abstract

A retrospective chart review was performed at the VA Portland Healthcare System Infectious Disease clinic. We identified all patients who received TRT for >6 months from 2000-2013. The comparison group was randomly selected with a 2:1 ratio of HIV patients who never took TRT (non-TRT group). The non-TRT group was group level matched based on age and duration of HIV diagnosis, and was selected from the same time period. Baseline data included demographics, comorbidies, medications, labs, CV risk factors and ART. Duration of TRT and adverse events (AE) were also collected. The primary outcomes were death and new CVE. Step-wise logistic regression was performed with a significance level of 0.05. There were 56 patients on TRT (median TRT duration 2.8 years, range 0.5-18.2 years) and 113 non-TRT patients evaluated. The TRT group had higher baseline hyperlipidemia, SBP>140 mmHg, and use of abacavir therapy (Table 1). There were 15/56 (26.8%) deaths in the TRT group v.s. 10/113 (8.8%), p=0.002. Incident CVE during the study interval was also significantly higher in the TRT group (Table 2). The odds of having a new CVE was significantly associated with TRT (OR=6.13, 95% CI=1.92,19.61, p=.002) even when controlling for antihypertensive therapy at baseline (OR=9.69, 95% CI=2.52,37.22, p=.001), CD4 count

Published
2015

10. ATS Core Curriculum 2014: part I. Adult pulmonary medicine

Author

Gautam George, Alison Morris, Melissa Nyendak, Carl D. Koch, Momen M. Wahidi, Gaetane C. Michaud, Richard G. Wunderink, Carey C. Thomson, Raj D. Shah, Colleen L. Channick, William S. Beckett, A. Christine Argento, Amit K. Mahajan, Kolene E. McDade, and David M. Lewinsohn

Subjects
Pulmonary and Respiratory Medicine, Adult, medicine.medical_specialty, Tuberculosis, Endemic Diseases, Antitubercular Agents, World Health Organization, Core curriculum, Risk Assessment, Pulmonary medicine, medicine, Prevalence, Pulmonary Medicine, Humans, Intensive care medicine, Lung cancer, Tuberculosis, Pulmonary, ATS Core Curriculum, business.industry, medicine.disease, Prognosis, Pneumonia, Treatment Outcome, Practice Guidelines as Topic, Education, Medical, Continuing, Curriculum, business
Published
2014

11. Mycobacterium tuberculosis specific CD8(+) T cells rapidly decline with antituberculosis treatment

Author

Deborah A. Lewinsohn, Harriet Mayanja-Kizza, David M. Lewinsohn, Denise F. Johnson, Melissa Nyendak, Mary Nsereko, Megan D. Null, John L. Johnson, Joy Baseke, Alphonse Okwera, Stefan V. Goldberg, Gwendolyn Swarbrick, Byung Park, Lorna Bozeman, Phineas Gitta, and W. Henry Boom

Subjects
Adult, Male, Tuberculosis, T cell, Antitubercular Agents, lcsh:Medicine, CD8-Positive T-Lymphocytes, Body Mass Index, Mycobacterium tuberculosis, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Species Specificity, medicine, Cytotoxic T cell, Humans, Phytohemagglutinins, lcsh:Science, 030304 developmental biology, 0303 health sciences, Multidisciplinary, biology, business.industry, Surrogate endpoint, ELISPOT, Malnutrition, lcsh:R, biology.organism_classification, medicine.disease, 3. Good health, medicine.anatomical_structure, Immunology, Multivariate Analysis, Sputum, Female, lcsh:Q, medicine.symptom, business, CD8, 030215 immunology, Research Article
Abstract

RATIONALE:Biomarkers associated with response to therapy in tuberculosis could have broad clinical utility. We postulated that the frequency of Mycobacterium tuberculosis (Mtb) specific CD8(+) T cells, by virtue of detecting intracellular infection, could be a surrogate marker of response to therapy and would decrease during effective antituberculosis treatment. OBJECTIVES:We sought to determine the relationship of Mtb specific CD4(+) T cells and CD8(+) T cells with duration of antituberculosis treatment. MATERIALS AND METHODS:We performed a prospective cohort study, enrolling between June 2008 and August 2010, of HIV-uninfected Ugandan adults (n = 50) with acid-fast bacillus smear-positive, culture confirmed pulmonary TB at the onset of antituberculosis treatment and the Mtb specific CD4(+) and CD8(+) T cell responses to ESAT-6 and CFP-10 were measured by IFN-γ ELISPOT at enrollment, week 8 and 24. RESULTS:There was a significant difference in the Mtb specific CD8(+) T response, but not the CD4(+) T cell response, over 24 weeks of antituberculosis treatment (p

Published
2013

12. Using Genomics to Get Rid of Pests

Author

Melissa Nyendak

Subjects
biology, HEK 293 cells, Dopaminergic, General Medicine, Aedes aegypti, Pharmacology, biology.organism_classification, Virology, Chemical library, chemistry.chemical_compound, chemistry, Dopamine receptor, Dopamine, medicine, Receptor, G protein-coupled receptor, medicine.drug
Abstract

Because a vaccine for many arthropod-borne diseases such as malaria and dengue is not currently available, a multidisciplinary approach to vector control with a focus on the interface between the mosquito and human habitat is important in lessening the human burden of disease. In this regard, vector control efforts focused on the eradication of standing water in combination with the use of insecticide-impregnated bed nets have been successful, albeit limited, stopgaps. However, vector resistance to insecticides and the limited number of novel compounds in development that are both environmentally sound and not toxic to humans remains a concern. Now, Meyer and colleagues demonstrate a genome-to-lead approach in the characterization of new dopaminergic targets in the mosquito A. aegypti , the vector for dengue and yellow fever, while providing an innovative approach for screening new compounds for other vector-borne diseases. G protein–coupled receptors (GPCRs), a family of molecules involved in multiple systems including neurotransmission and vision, have been tapped as a new insecticide target. In the mosquito, a GPCR acts as a dopamine receptor in the salivary gland and may affect vector transmission during blood feeding. To study a novel dopaminergic target for mosquito control, Meyer and colleagues first identified gene sequences for dopamine receptors ( Aadop1 and Aadop2 ) from an open source platform, VectorBase. To evaluate gene expression of these regions, RNA was extracted from the eggs, larvae, and pupae of the mosquitoes and amplified by using reverse transcription polymerase chain reaction. With the mRNA sequences that encode the dopamine receptors in hand, the investigators predicted the protein sequences and structures and thus defined the familial relationship between AaDOP1 and AaDOP2 and other amine receptors. This analysis provided evidence for conserved regions as well as other unique areas that may be targeted by novel insecticides. To assign function to AaDOP1 and AaDOP2, their encoding genes were expressed in human embryonic kidney 293 cells. The investigators focused on the Aadop2 gene for the antagonist screen because it was not stimulated by sister biogenic amines (norepinephrine and epinephrine) and had a strong dopamine response with low constitutive activity. Using a chemical library derived from the Library of Pharmacologically Active Compounds (LOPAC1280), Meyer and colleages evaluated various substances that inhibited dopamine by at least 81%. Fifty-one antagonists were defined that ranged in function from pure dopamine antagonists to compounds that affected the cell cycle and apoptosis. Because of the concern about possible cross-reactivity with the human dopamine receptor, compounds designated as hits underwent a second set of experiments to assess cross-toxicity. Interestingly, when compared with the human dopamine receptor, AaDOP2 displayed different binding properties for several of the compounds identified in the screen. Two of the compounds, amitriptyline and doxepin, exhibited unique pharmacology when compared with the human dopamine receptor and, when studied in larval experiments, demonstrated killing at effective drug concentrations. The last insecticide was developed nearly 30 years ago, and as such, there is evolutionary pressure to develop new, safe alternatives. The genome-to-lead approach defined here offers a strategic genomic approach toward high-throughput screening for new compounds or, as shown in this study, old compounds with a new use. J. M. Meyer et al. , A “genome-to-lead” approach for insecticide discovery: Pharmacological characterization and screening of Aedes aegypti D1-like dopamine receptors. PLoS Negl. Trop. Dis. 6 , e1478 (2012). [[Abstract]][1] [1]: http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0001478

Published
2012

13. Just a Spoonful of Drug Makes Diversity Go Down

Author

Melissa Nyendak

Subjects
Pediatrics, medicine.medical_specialty, biology, medicine.drug_class, business.industry, Antibiotics, Clindamycin, General Medicine, Pseudomembranous colitis, Gut flora, Clostridium difficile, medicine.disease, biology.organism_classification, Microbiology, Cecum, Antibiotic resistance, medicine.anatomical_structure, medicine, Colitis, business, medicine.drug
Abstract

In their “Get Smart For Health Care” campaign, the U.S. Centers for Disease Control and Prevention targets inappropriate use of antibiotics, citing that up to 50% of uses in hospitals alone are unnecessary. In addition to lessening cost, reducing unnecessary antibiotic use decreases antimicrobial resistance and Clostridium difficile infections (CDIs). This nosocomial pathogen is linked to prior antibiotic exposure and causes a spectrum of diarrheal diseases from mild illness to fatal pseudomembranous colitis. Antibiotics—and clindamycin is especially notorious—may promote CDIs by disrupting the normal homeostasis of resident bowel flora, killing some bacteria while letting others flourish. But little is known about the mechanisms behind this shift and the subsequent emergence of C. difficile . Now, in a mouse model, Buffie and colleagues use a genetic amplification aproach to assess changes in intestinal microbial composition after a single dose of clindamycin and find that the drug reduces microbial diversity and renders mice susceptible to CDIs. Mice that received clindamycin before an oral challenge of C. difficile were more susceptible to disease and died at a higher rate relative to control animals. In addition, among mice that survived bacterial challenge, those treated with clindamycin retained toxin-producing C. difficile in their guts at 28 days along with postinfectious histological changes consistent with damage to the cecum and ileum. Using a technique known as 16 S ribosomal RNA genetic amplification to assess the microbial composition of the ileum and cecum, the authors demonstrated that mice not exposed to clindamycin had similar microbial diversity whether or not they had received a C. difficile oral challenge. In contrast, mice treated with clindamycin had significant and contracted changes in microbial diversity that lasted at least 4 weeks. The investigators also showed that mice that had been treated with clindamycin were susceptible to CDIs for at least 10 days after C. difficile exposure. The new work reveals that a loss of microbial diversity from the cecal and ileal reservoirs after antibiotic administration has long-term consequences in terms of CDI risk, at least in mice. Using this model system, researchers have an opportunity to identify residual members of the gut microbiota that play a role in C. difficile “resistance” and how protective microbial populations may be preserved in the face of ongoing antibiotic pressure. C. G. Buffie et al ., Profound alterations of intestinal microbiota following a single dose of clindamycin results in sustained susceptibility to Clostridium difficile –induced colitis. Infect. Immun . 80 , 62–73 (2012). [[Abstract]][1] [1]: http://iai.asm.org/content/80/1/62.abstract

Published
2012

14. CD8+ T Cells Provide an Immunologic Signature of Tuberculosis in Young Children

Author

Christina Lancioni, Megan D. Null, Philipa Mudido-Musoke, Laura Byrd, Melissa Nyendak, La Shaunda L. Malone, Stephen Balyejusa, Tomi Mori, Christine Scott, Harriet Mayanja-Kizza, W. Henry Boom, Sarah Zalwango, David M. Lewinsohn, Joy Baseke, Deborah A. Lewinsohn, Gwendolyn Swarbrick, Denise F. Johnson, Deo Mulindwa, and Sarah Kiguli

Subjects
Pulmonary and Respiratory Medicine, Male, Tuberculosis, Recombinant Fusion Proteins, Enzyme-Linked Immunosorbent Assay, CD8-Positive T-Lymphocytes, Critical Care and Intensive Care Medicine, Peripheral blood mononuclear cell, Statistics, Nonparametric, Mycobacterium tuberculosis, Interferon-gamma, Immune system, Antigen, Bacterial Proteins, Medicine, Cytotoxic T cell, Humans, Interferon gamma, Uganda, Child, Tuberculosis, Pulmonary, Antigens, Bacterial, biology, business.industry, Articles, biology.organism_classification, medicine.disease, Virology, Hospitalization, Cross-Sectional Studies, Child, Preschool, Immunology, Female, business, CD8, Biomarkers, medicine.drug
Abstract

The immunologic events surrounding primary Mycobacterium tuberculosis infection and development of tuberculosis remain controversial. Young children who develop tuberculosis do so quickly after first exposure, thus permitting study of immune response to primary infection and disease. We hypothesized that M. tuberculosis-specific CD8(+) T cells are generated in response to high bacillary loads occurring during tuberculosis.To determine if M. tuberculosis-specific T cells are generated among healthy children exposed to M. tuberculosis and children with tuberculosis.Enzyme-linked immunosorbent spot assays were used to measure IFN-γ production in response to M. tuberculosis-specific proteins ESAT-6/CFP-10 by peripheral blood mononuclear cells and CD8(+) T cells isolated from Ugandan children hospitalized with tuberculosis (n = 96) or healthy tuberculosis contacts (n = 62).The proportion of positive CD8(+) T-cell assays and magnitude of CD8(+) T-cell responses were significantly greater among young (5 yr) tuberculosis cases compared with young contacts (P = 0.02, Fisher exact test, P = 0.01, Wilcoxon rank-sum, respectively). M. tuberculosis-specific T-cell responses measured in peripheral blood mononuclear cells were equivalent between groups.Among young children, M. tuberculosis-specific CD8(+) T cells develop in response to high bacillary loads, as occurs during tuberculosis, and are unlikely to be found after M. tuberculosis exposure. T-cell responses measured in peripheral blood mononuclear cells are generated after M. tuberculosis exposure alone, and thus cannot distinguish exposure from disease. In young children, IFN-γ-producing M. tuberculosis-specific CD8(+) T cells provide an immunologic signature of primary M. tuberculosis infection resulting in disease.

Published
2012

15. MASCC Index

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

16. Musculoskeletal Trauma, Dislocation

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

17. Muscle Atrophy

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

18. Methicillin-Resistant Staphylococcus aureus (MRSA)

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

19. Mass-Casualty Event (MCE)

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

20. Musculoskeletal Trauma, Pelvic Ring Disruption

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

21. Medical Management of Brain Death

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

22. Multiple Organ Dysfunction

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

23. Mannitol in the Critically Ill Patient with Acute Kidney Injury

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

24. Minimally Invasive Hemodynamic Monitoring System

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

25. Motor Vehicle Collision

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

26. MRSA Prevention

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

27. Malnutrition

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

28. Myocarditis and Acute Cardiomyopathies

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

29. Malta Fever

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

30. Musculoskeletal Trauma, Damage Control, and Pelvic Binder

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

31. Myocardial Concussion

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

32. MBI

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

33. Myasthenia Gravis

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

34. Metroperitonitis

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

35. Myocarditis in Children

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

36. Musculoskeletal Trauma, Preperitonal Pelvic Packing

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

37. Meat-Cutter’s Disease

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

38. Meningitis

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

39. Mangled Extremity

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

40. Multidrug-Resistant Tuberculosis (MDR TB)

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

41. Muscle Necrosis

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

42. Mycobacterium tuberculosis: Tuberculosis, TB

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

43. Multiple Organ Dysfunction Syndrome

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

44. Multiple Dosed Activated Charcoal (MDAC)

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

45. Multiple Organ Failure (MOF)

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

46. Metabolic Concerns in Acute Renal Failure

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

47. Myonecrosis

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

48. Multiplate® Analyzer

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

49. Massive Transfusion

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

50. Mitral Valvular Disease

Author

Denis D. Bensard, Philip F. Stahel, Jorge Cerdá, Babak Sarani, Sajid Shahul, Daniel Talmor, Peter M. Hammer, C. William Schwab, Steven Reynolds, Omar Ahmad, Tsuyoshi Kaneko, Anthony L. Estrera, William A. Knight, Bradley P. Dixon, Richard L. Gamelli, Joseph A. Posluszny, Mansoor N. Bangash, Rupert M. Pearse, Albert J. Ruggieri, Richard J. Levy, Clifford S. Deutschman, Prasanna Simha Mohan Rao, John P. Kress, Sabino Scolletta, Norman E. McSwain, Jeffry L. Kashuk, Angela Sauaia, Ernest E. Moore, Per-Olof J. Hasselgren, Wade R. Smith, John T. Riehl, Berton R. Moed, B. Kirke Bieneman, Clay C. Cothren, Nima Majlesi, Richard D. Shih, Eelco F. M. Wijdicks, Melissa Nyendak, Tarek Eid, Payam Nahid, Kevin Winthrop, David Lewinsohn, Julie P. Chou, Tom Lim, Andrew G. Lee, Christopher H. Mody, Nathan T. Mowery, Alexander L. Colonna, J. Wayne Meredith, Alain Combes, Jonathan R. Egan, Marino S. Festa, A. Montcriol, Y. Asencio, and F. Kerbaul

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results