Search

Context: We have abundant plant resources with many health benefits. Use of plant material for health benefits will help in reduce the cost of drugs and also provide a substitute drug that is less expensive. Coleus amboinicus is plant largely distributed in Dakshina kannada and is used for its medicinal properties as household cure. Aim: We planned to find out the anti-inflammatory and peripheral analgesic activity of Aqueous Extract of leaves of Coleus amboinicus. Settings and Design: Wistar albino rats were randomly selected and tests were performed by dividing the animals into three groups- control, standard, test. Materials and Methods: Aqueous extract of leaves of Coleus amboinicus was prepared using soxhlet apparatus. The dose of leaf extract used was 500mg/kg. Statistical Analysis: Data was analysed by applying one way ANOVA followed by Dunnets multiple comparison test using Graphpad Instat. Results: The results obtained were statistically significant. In Carragenan induced inflammation model significant inhibition of inflammation was shown by the test drug at the end of 3 hrs and in Acetic acid induced writing test significant inhibition of occurrence of writhes was noted by the test drug. Conclusion: This study validates the folkloric use of aqueous extract of leaves of Coleus amboinicus (AECA) at the dose of 500mg/kg for its anti-inflammatory and peripheral analgesic activity. Keywords: Coleus amboinicus, Aqueous extract, Antiinflammatory, Carragenan induced writhing test, Acetic acid induced writhing test.