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This paper introduces a new approach to neuromorphic photonics in which microcavities exhibiting strong exciton-photon interaction may serve as building blocks of optical spiking neurons. The experimental results demonstrate the intrinsic property of exciton-polaritons to resemble the Leaky Integrate-and-Fire spiking mechanism. It is shown that exciton-polariton microcavities when non-resonantly pumped with a pulsed laser exhibit leaky-integration due to relaxation of the excitonic reservoir, threshold-and-fire mechanism due to transition to Bose-Einstein condensate, and resetting due to stimulated emission of photons. These effects, evidenced in photoluminescence characteristics, arise within sub-ns timescales. The presented approach provides means for energy-efficient ultrafast processing of spike-like laser pulses at the level below 1 pJ/spike.

Multicomponent Bose-Einstein condensates, quantum Hall systems, and chiral magnetic materials display twists and knots in the continuous symmetries of their order parameter, known as Skyrmions. Originally discovered as solutions to the nonlinear sigma model in quantum field theory, these vectorial excitations are quantified by a topological winding number dictating their interactions and global properties of the host system. Here, we report the first experimental observation of a stable individual second order meron, and antimeron, appearing in an electromagnetic field. These complex textures are realised by confining light into a liquid-crystal filled cavity which, through its anisotropic refractive index, provides an adjustable artificial photonic gauge field which couples the cavity photons motion to its polarisation resulting in formation of these fundamental vectorial vortex states of light. Our observations take a step towards bringing topologically robust room-temperature optical vector textures into the field of photonic information processing and storage.

Carbon capture and storage (CCS) is broadly recognised as having the potential to play a key role in meeting climate change targets, delivering low carbon heat and power, decarbonising industry and, more recently, its ability to facilitate the net removal of CO2 from the atmosphere. However, despite this broad consensus and its technical maturity, CCS has not yet been deployed on a scale commensurate with the ambitions articulated a decade ago. Thus, in this paper we review the current state-of-the-art of CO2 capture, transport, utilisation and storage from a multi-scale perspective, moving from the global to molecular scales. In light of the COP21 commitments to limit warming to less than 2 °C, we extend the remit of this study to include the key negative emissions technologies (NETs) of bioenergy with CCS (BECCS), and direct air capture (DAC). Cognisant of the non-technical barriers to deploying CCS, we reflect on recent experience from the UK's CCS commercialisation programme and consider the commercial and political barriers to the large-scale deployment of CCS. In all areas, we focus on identifying and clearly articulating the key research challenges that could usefully be addressed in the coming decade.

Carbon capture and storage (CCS) is broadly recognised as having the potential to play a key role in meeting climate change targets, delivering low carbon heat and power, decarbonising industry and, more recently, its ability to facilitate the net removal of CO2 from the atmosphere. However, despite this broad consensus and its technical maturity, CCS has not yet been deployed on a scale commensurate with the ambitions articulated a decade ago. Thus, in this paper we review the current state-of-the-art of CO2 capture, transport, utilisation and storage from a multi-scale perspective, moving from the global to molecular scales. In light of the COP21 commitments to limit warming to less than 2 °C, we extend the remit of this study to include the key negative emissions technologies (NETs) of bioenergy with CCS (BECCS), and direct air capture (DAC). Cognisant of the non-technical barriers to deploying CCS, we reflect on recent experience from the UK's CCS commercialisation programme and consider the commercial and political barriers to the large-scale deployment of CCS. In all areas, we focus on identifying and clearly articulating the key research challenges that could usefully be addressed in the coming decade.\ud \ud

© 2018 The Royal Society of Chemistry. Carbon capture and storage (CCS) is broadly recognised as having the potential to play a key role in meeting climate change targets, delivering low carbon heat and power, decarbonising industry and, more recently, its ability to facilitate the net removal of CO2 from the atmosphere. However, despite this broad consensus and its technical maturity, CCS has not yet been deployed on a scale commensurate with the ambitions articulated a decade ago. Thus, in this paper we review the current state-of-the-art of CO2 capture, transport, utilisation and storage from a multi-scale perspective, moving from the global to molecular scales. In light of the COP21 commitments to limit warming to less than 2 °C, we extend the remit of this study to include the key negative emissions technologies (NETs) of bioenergy with CCS (BECCS), and direct air capture (DAC). Cognisant of the non-technical barriers to deploying CCS, we reflect on recent experience from the UK's CCS commercialisation programme and consider the commercial and political barriers to the large-scale deployment of CCS. In all areas, we focus on identifying and clearly articulating the key research challenges that could usefully be addressed in the coming decade.

International audience

Bose-Einstein condensate of exciton polaritons in a semiconductor microcavity is a macroscopically populated coherent quantum state subject to concurrent pumping and decay. Debates about the fundamental nature of the condensed phase in this open quantum system still persist. Here, we gain a new insight into the spontaneous condensation process by imaging long-lifetime exciton polaritons in a high-quality inorganic microcavity in the single-shot optical excitation regime, without averaging over multiple condensate realisations. In this highly non-stationary regime, a condensate is strongly influenced by the `hot' incoherent reservoir, and reservoir depletion is critical for the transition to the ground energy and momentum state. Condensates formed by more photonic exciton polaritons exhibit dramatic reservoir-induced density filamentation and shot-to-shot fluctuations. In contrast, condensates of more excitonic quasiparticles display smooth density and are second-order coherent. Our observations show that the single-shot measurements offer a unique opportunity to study formation of macroscopic phase coherence during a quantum phase transition in a solid state system., 18 pages, 5 figures

We demonstrate the existence of a novel quasiparticle, an exciton in a semiconductor doubly dressed with two photons of different wavelengths: a near infrared cavity photon and terahertz (THz) photon, with the THz coupling strength approaching the ultrastrong coupling regime. This quasiparticle is composed of three different bosons, being a mixture of a matter-light quasiparticle. Our observations are confirmed by a detailed theoretical analysis, treating quantum mechanically all three bosonic fields. The doubly dressed quasiparticles retain the bosonic nature of their constituents, but their internal quantum structure strongly depends on the intensity of the applied terahertz field.

International audience; In recent years indirect (dipolar) excitons have emerged as highly interesting objects for fundamental studies like Bose-Einstein condensation as well as a concept of excitonic devices for development of excitonic signal processing. An indirect exciton (IX) is a bound pair of an electron and a hole (e-h) in spatially separated quantum wells (QWs). Studies of IX have been concentrated almost entirely on (Al,Ga)As/GaAs coupled double QWs (CDQWs). Due to the large exciton binding energy polar heterostructures of Group III nitrides seem to be more suitable for observation of IX. In the present work we have studied IXs formed by a e-h pair in InGaN/GaN CDQWs. Very thin barrier of 1-2 atomic monolayer (ML) separating QWs enables a tunneling of electrons and holes after optical excitation to the adjacent QWs. The samples consisted of DQWs of In0.17Ga0.83N/In0.02Ga0.98N grown by MBE technique. Intended width of QWs was 2.6 nm and the barrier thickness varied between 1- 8 ML (025-2nm). GaN crystals were used as substrates. The XRD and TEM measurements showed that the obtained structures agree well with the intended ones. Modeling of their band structure using the NEXTNANO software revealed that the structures with the thinnest barriers (1-2 ML) formed one electron (hole) state located in the conduction (valence) band of adjacent QWs. The corresponding emission wavelength was λ≈510 nm. Simulations performed for structures with the thicker barriers demonstrated presence of e- and h-states in each QW and the emission at λ≈450nm. PL measured in these samples showed such an emission. For structures with 1-2 ML barrier we found a peak at λ≈505-520nm which we associated with IX in the system of CDQW. To prove strongly indirect character of the long-wavelength PL-band we performed TRPL characterization of the studied structures. At T=4K, the band at λ≈510nm showed the decay time, τD, approaching msec range. Whereas the band at λ≈450nm is characterized by τD of about 100 ns.

We discuss the structure of spin-1 Bose–Einstein condensates in the presence of a homogenous magnetic field. We demonstrate that the phase separation can occur in the ground state of antiferromagnetic (polar) condensates, while the spin components of the ferromagnetic condensates are always miscible, and no phase separation occurs. Our analysis predicts that this phenomenon takes place when the energy of the lowest homogenous state is a concave function of the magnetization. We propose a method for generation of spin domains by adiabatic switching of the magnetic field. We also discuss the phenomena of dynamical instability and spin domain formation.

A new approximation for evolution described by Nonlinear Schrodinger Equation (NLS) with periodic potential is presented. It relies on restricting dynamics to one band of the bandgap spectrum, and taking into account only one, dominating Fourier component in the nonlinear Bloch-wave mixing. The resulting equation has a simple, discrete form in the basis of linear Wannier functions, and turns out to be very accurate as long as the modes in other bands are not excited and the potential is not very deep. Widely used approximations, the tight-binding approximation and the effective mass approximation, are derived from the new equation as the limiting cases.

At present it is known that the adjustment of the anticancer therapy to the circadian rhythms in tissues reduces the toxicity of the treatment. Chronotherapy also increases the efficacy of the anticancer treatment, which has been proved for many drugs. Sunitinib is a tyrosine kinase inhibitor, which is broadly used for the treatment of numerous cancers. The aim of the study was a comparison of the concentrations and pharmacokinetics of sunitinib after a single administration to rabbits at 08:00 (control group) and 20:00. Additionally, the effect of sunitinib on glucose levels was investigated.The research was carried out on two groups of rabbits: I08:00, a group with the drug administered at 08:00 (n=8) and II20:00, a group with the drug administered at 20:00 (n=8). The rabbits were treated with sunitinib at an oral dose of 25 mg. Plasma concentrations of sunitinib and its metabolite (SU12662) were measured with a validated HPLC method with UV detection.The comparison of the sunitinib Cmax and AUC0-t in the group with sunitinib administered at 20:00 with the control group gave the ratios of 2.20 (90% confidence interval (CI) (2.17; 2.22) and 1.64 (1.61; 1.68), respectively. Statistically significant differences between the groups under analysis were revealed for Cmax (p0.0001), AUC0-t (p = 0.0079), AUC0-∞ (p = 0.0149), and tmax (p = 0.0085). The mean glycemia drop was higher in group I08:00. than in group II20:00 (22.7% vs. 14.3%; p = 0.0622). The glycemia values returned to the initial values in 24 h after the administration of the drug in both groups.The research proved a significant influence of the time-of-day administration on the pharmacokinetics of sunitinib.

Introduction Stress urinary incontinence (SUI) is defined as an involuntary loss of urine during physical exertion, sneezing, coughing, laughing, or other activities that put pressure on the bladder. In some cases, recurrent or persistent SUI after sling operations may be caused by too loose placement of the sling. In the current study, we describe our method of shortening of the sling as a second-line treatment of tension-free vaginal tape (TVT) failure. Materials and methods Four women, aged 46-61, after initial TVT operation were treated for persistent SUI. The severity of SUI was estimated by: physical examinations, cough tests, 24-h pad tests, and King's Health Questionnaire. The shortening procedure, based on excising the fragment of tape and suturing it back, was performed in all patients. Results All cases achieved a good result, which was defined as restoration of full continence. No complications occurred. The 12-month follow-up showed no side-effects. The postoperative control tests: the cough and 24-h pad tests were negative in all women. The general health perceptions increased after the shortening procedure by a mean value 44.25%. The incontinence impact decreased by a mean value 44.6%. In all patients, role and physical limitations significantly decreased (by 88.5% and 80.5%, respectively). The negative emotions connected with SUI significantly decreased after the second procedure. Conclusions The operative shortening of the implanted sling is a simple, cheap, and effective method of second-line treatment in cases of TVT failure and may be offered to the majority of patients with insufficient urethral support after the first procedure.

Metastatic tumors of the penis are rare. They are usually secondary to primaries of the genitourinary and gastrointestinal tracts. This entity is usually accompanied by distressing symptoms like dysuria, pain, induration, swelling of the penis and priapism, making immediate intervention necessary. Different methods of treatment are used to achieve the palliative effect: local surgical excision, penis amputation, radiotherapy or chemotherapy. Nevertheless, the prognosis is poor, because the disease is already disseminated and in most cases other metastases will occur soon.

Kidney disease; Cancer Enfermedad renal; Cáncer Malaltia renal; Càncer Onco-nephrology is a new field of medicine which combines many aspects of kidney injury in cancer patients and cancers in patients with kidney disease. This connection takes many forms and includes drug-induced nephrotoxicity, electrolyte disorders, numerous paraneoplastic syndromes and an increased rate cancers in dialysis and transplanted patients. The appropriate laboratory assessment of the kidney function allows to optimize chemotherapy and thus minimizes the risk of complications. This article focuses on acute kidney injury (AKI), chronic kidney disease (CKD), various electrolyte and acid-base disorders, the most common cancers after kidney transplantation and the kidney disorders associated with HSCT (hematopoietic stem cell transplantation). The possibility of the application of novel cancer therapy, such as cancer immunotherapy and proton therapy in transplant recipients was also discussed.

Tumor-to-stroma ratio (TSR) is a prognostic factor that expresses the relative amounts of tumor and intratumoral stroma. In this study, its clinical and molecular relevance was evaluated in prostate cancer (PCa). The feasibility of automated quantification was tested in digital scans of tissue microarrays containing 128 primary tumors from 72 PCa patients stained immunohistochemically for epithelial cell adhesion molecule (EpCAM), followed by validation in a cohort of 310 primary tumors from 209 PCa patients. In order to investigate the gene expression differences between tumors with low and high TSR, we applied multigene expression analysis (nCounter® PanCancer Progression Panel, NanoString) of 42 tissue samples. TSR scores were categorized into low (&lt, 1 TSR) and high (≥1 TSR). In the pilot cohort, 31 patients (43.1%) were categorized as low and 41 (56.9%) as high TSR score, whereas 48 (23.0%) patients from the validation cohort were classified as low TSR and 161 (77.0%) as high. In both cohorts, high TSR appeared to indicate the shorter time to biochemical recurrence in PCa patients (Log-rank test, p = 0.04 and p = 0.01 for the pilot and validation cohort, respectively). Additionally, in the multivariate analysis of the validation cohort, TSR predicted BR independent of other factors, i.e., pT, pN, and age (p = 0.04, HR 2.75, 95%CI 1.07–7.03). Our data revealed that tumors categorized into low and high TSR score show differential expression of various genes, the genes upregulated in tumors with low TSR score were mostly associated with extracellular matrix and cell adhesion regulation. Taken together, this study shows that high stroma content can play a protective role in PCa. Automatic EpCAM-based quantification of TSR might improve prognostication in personalized medicine for PCa.

Machine learning software applications are ubiquitous in many fields of science and society for their outstanding capability to solve computationally vast problems like the recognition of patterns and regularities in big data sets. In spite of these impressive achievements, such processors are still based on the so-called von Neumann architecture, which is a bottleneck for faster and power-efficient neuromorphic computation. Therefore, one of the main goals of research is to conceive physical realizations of artificial neural networks capable of performing fully parallel and ultrafast operations. Here we show that lattices of exciton-polariton condensates accomplish neuromorphic computing with outstanding accuracy thanks to their high optical nonlinearity. We demonstrate that our neural network significantly increases the recognition efficiency compared with the linear classification algorithms on one of the most widely used benchmarks, the MNIST problem, showing a concrete advantage from the integration of optical systems in neural network architectures. Accepted version ERC “ElecOpteR” Grant 780757 Singapore, MOE2017-T2-1-001 Singapore, MOE2018-T2-02-068 Poland, 2016/22/E/ST3/ 00045 Poland, 2017/25/Z/ST3/03032

Post starburst E+A galaxies show indications of a powerful starburst that was quenched abruptly. Their disturbed, bulge-dominated morphologies suggest that they are merger remnants. The more massive E+A galaxies are suggested to be quenched by AGN feedback, yet little is known about AGN-driven winds in this short-lived phase. We present spatially-resolved IFU spectroscopy by the Keck Cosmic Web Imager of SDSS J003443.68+251020.9, at z=0.118. The system consists of two galaxies, the larger of which is a post starburst E+A galaxy hosting an AGN. Our modelling suggests a 400 Myrs starburst, with a peak star formation rate of 120 Msun/yr. The observations reveal stationary and outflowing gas, photoionized by the central AGN. We detect gas outflows to a distance of 17 kpc from the central galaxy, far beyond the region of the stars (about 3 kpc), inside a conic structure with an opening angle of 70 degrees. We construct self-consistent photoionization and dynamical models for the different gas components and show that the gas outside the galaxy forms a continuous flow, with a mass outflow rate of about 24 Msun/yr. The gas mass in the flow, roughly $10^9$ Msun, is larger than the total gas mass within the galaxy, some of which is outflowing too. The continuity of the flow puts a lower limit of 60 Myrs on the duration of the AGN feedback. Such AGN are capable of removing, in a single episode, most of the gas from their host galaxies and expelling enriched material into the surrounding CGM., Comment: submitted to MNRAS; comments are welcome!

Generating electricity using Renewable Energy Sources (RES) is taking over more and more shares in the global market of energy production. This results from global energy policy which is closely related to the reduction of greenhouse gas emission and environmental pollution as well as to reducing consumption of fossil fuels. The constantly increasing number of producers of electricity from RES, such as Hydroelectric Power Plants and Small Hydroelectric Power Plants, gives an impulse for carrying out work on the development and improvement of their operation. It forces continuous work on development of technical diagnostics methods which allow to detect faults at an early stage and even, using properly designed systems, to prevent them or minimize their effects. The main task of the diagnostics and control systems is to identify any symptoms of inaccurate device operation. Next, to modify the algorithm so that the device is introduced to the area of correct operation. Detecting a defect at its initial phase gives opportunities to plan and prepare for the repair of the device. Using appropriate diagnostic methods helps to minimize the costs of major repairs and overhauls of machines and maintain the work efficiency at the desired level. This article presents selected diagnostic methods used in Hydropower Plants.

Theory suggests that there are two primary modes of accretion through which dark-matter halos acquire the gas to form and fuel galaxies: hot- and cold-flow accretion. In cold-flow accretion, gas streams along cosmic web filaments to the centre of the halo, allowing for the efficient delivery of star-forming fuel. Recently, two quasar-illuminated H i Lyman ɑ (Lyα)-emitting objects were reported to have properties of cold, rotating structures1,2. However, the spatial and spectral resolution available was insufficient to constrain the radial flows associated with connecting filaments. With the Keck Cosmic Web Imager (KCWI)3, we now have eight times the spatial resolution, permitting the detection of these inspiralling flows. To detect these inflows, we introduce a suite of models that incorporate zonal radial flows, demonstrate their performance on a numerical simulation that exhibits cold-flow accretion, and show that they are an excellent match to KCWI velocity maps of two Lyα emitters observed around high-redshift quasars. These multi-filament inflow models kinematically isolate zones of radial inflow that correspond to extended filamentary emission. The derived gas flux and inflow path is sufficient to fuel the inferred central galaxy star-formation rate and angular momentum. Thus, our kinematic emission maps provide strong evidence that the inflow of gas from the cosmic web is building galaxies at the peak of star formation.

Quantum fluids of light are an emerging platform for energy-efficient signal processing, ultrasensitive interferometry and quantum simulators at elevated temperatures. Here we demonstrate all-optical control of the topological excitations in a large polariton condensate realizing the bosonic analogue of a long Josephson junction and inducing the nucleation of Josephson vortices. When a phase difference is imposed at the boundaries of the condensate, two extended regions become separated by a sharp phase jump of π radians and a solitonic depletion of the density, forming an insulating barrier with a suppressed order parameter. The superfluid behaviour—characterized by a smooth phase gradient across the system instead of the sharp phase jump—is recovered at higher polariton densities and is mediated by the nucleation of Josephson vortices within the barrier. Our results contribute to the understanding of dissipation and stability of elementary excitations in macroscale quantum systems. All-optical control of the topological excitations of a superfluid of light is demonstrated in a high-quality-factor semiconductor microcavity. Recovery of superfluid behaviour at high polariton densities and bosonic Josephson vortices are observed.

Enormous Lyα nebulae (ELANe) represent the extrema of Lyα nebulosities. They have detected extents of >200 kpc in Lyα and Lyα luminosities >10^(44) erg s^(−1). The ELAN population is an ideal laboratory to study the interactions between galaxies and the intergalactic/circumgalactic medium (IGM/CGM) given their brightness and sizes. The current sample size of ELANe is still very small, and the few z ≈ 2 ELANe discovered to date are all associated with local overdensities of active galactic nuclei (AGNs). Inspired by these results, we have initiated a survey of ELANe associated with quasi-stellar object (QSO) pairs using the Palomar and Keck Cosmic Web Imagers (PCWI/KCWI). In this Letter, we present our first result: the discovery of ELAN0101+0201 associated with a QSO pair at z = 2.45. Our PCWI discovery data shows that, above a 2σ surface brightness of 1.2 × 10^(−17) erg s^(−1) cm^(−2) arcsec^(−2), the end-to-end size of ELAN0101+0201 is ≳ 232 kpc. We have conducted follow-up observations using KCWI, resolving multiple Lyα emitting sources within the rectangular field of view of ≈ 130 × 165 projected kpc^2, and obtaining their emission line profiles at high signal-to-noise ratios (S/Ns). Combining both KCWI and PCWI, our observations confirm that ELAN0101+0201 resides in an extremely overdense environment. Our observations further support that a large amount of cool (T ~ 10^4 K) gas could exist in massive halos (M ≳ 10^(13) M_⊙) at z ≈ 2. Future observations on a larger sample of similar systems will provide statistics of how cool gas is distributed in massive overdensities at high redshift and strongly constrain the evolution of the intracluster medium.

Polaritons in microcavities are versatile quasi-2D bosonic particles with a high degree of coherence and strong nonlinearities, thanks to their hybrid light-matter character. In their condensed form, they display striking quantum hydrodynamic features analogous to atomic Bose-Einstein condensates, such as long-range order coherence, superfluidity and quantized vorticity. Their variegated dispersive and dissipative properties, however, set significant differences from their atomic counterpart. In this work, we report the unique phenomenology that is observed when a pulse of light impacts the polariton vacuum: the condensate that is instantaneously formed does not splash in real space but instead coheres into an enigmatic structure, featuring concentric rings and, most notably, a sharp and bright peak at the center. Using a state-of-the-art ultrafast imaging with 50 fs time steps, we are able to track the dynamics of the polariton mean-field wavefunction in both real and reciprocal space. The observation of the real-space collapse of the condensate into an extremely localized---resolution limited---peak is at odd with the repulsive interactions of polaritons and their positive effective mass. An unconventional mechanism is therefore at play to account for our observations. Our modeling suggests that self-trapping due to a local heating of the crystal lattice---that can be described as a collective polaron formed by a polariton condensate---could be involved. These observations hint at the fascinating fluid dynamics of polaritons in conditions of extreme intensities and ultrafast times., Comment: New version complete with revised theoretical interpretation and added material. 8 pages, 5 figures, supplementary 12 pages, 15 figures. Supplementary videos: https://drive.google.com/folderview?id=0B0QCllnLqdyBZUNXMTdTNUNhdUk