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In precise orbit determination (POD) for GNSS satellites, the solar radiation pressure (SRP) that is the largest non-gravitational acceleration is a major error source. Usually, we correct SRP by using the empirical model in POD, but it is not enough. The Japan Aerospace Exploration Agency (JAXA) has been proceeding the research and development of the high-precision accelerometer that can be mounted on a satellite and measure non-gravitational acceleration directly to use acceleration data for POD. For Quasi-Zenith Satellite System satellites, the maximum acceleration caused by SRP is about 10-7m/s2, and the accuracy of JAXA's SRP model is order of 10-9m/s2. To improve the correction accuracy of non-gravitational acceleration, we need to the accelerometer which has a measurement resolution of 10-10m/s2 or less. Our goal is to improve the accuracy of non-gravitational force model by an order of magnitude. Therefore, we have been making the prototype of accelerometer that consist of the interferometric sensor, test mass, and actuator. In particular, we adopted the quadrature laser interferometer which has the advantage of both high sensitivity and wide measurement range for the interferometric sensor. Last two years, we have made the interferometric sensor and a part of the test mass and have evaluated their performance. Currently, we have been making multiple breadboard models (BBMs) of the accelerometer. By simultaneously measuring by multiple BBMs, we are planning to eliminate common-mode noise such as ground motions and evaluate their performance. In this presentation, we explain overview and status of this R&D., The 28th IUGG General Assembly (IUGG2023) (Berlin 2023)

Background: Postoperative atrial fibrillation (POAF) occurs in 20% to 50% of patients soon after cardiac surgery, and is associated with subsequent newly developed AF. Left atrial appendage closure is effective in preventing stroke among patients with nonvalvular AF. However, the prophylactic effect of left atrial appendage amputation (LAAA) in stroke prevention among patients with sinus rhythm has not been proven. Methods: We analyzed 977 consecutive patients undergoing off-pump coronary artery bypass grafting (OPCAB) with sinus rhythm, with or without concomitant LAAA, from 2011 to 2017 at our institution in a retrospective observational manner. A total of 550 patients (56.3%) underwent concomitant LAAA, any effect thereof in preventing early (

Event Horizon Telescope (EHT) observations at 230 GHz have now imaged polarized emission around the supermassive black hole in M87 on event-horizon scales. This polarized synchrotron radiation probes the structure of magnetic fields and the plasma properties near the black hole. Here we compare the resolved polarization structure observed by the EHT, along with simultaneous unresolved observations with the Atacama Large Millimeter/submillimeter Array, to expectations from theoretical models. The low fractional linear polarization in the resolved image suggests that the polarization is scrambled on scales smaller than the EHT beam, which we attribute to Faraday rotation internal to the emission region. We estimate the average density n e ∼ 104-7 cm-3, magnetic field strength B ∼ 1-30 G, and electron temperature T e ∼ (1-12) 1010 K of the radiating plasma in a simple one-zone emission model. We show that the net azimuthal linear polarization pattern may result from organized, poloidal magnetic fields in the emission region. In a quantitative comparison with a large library of simulated polarimetric images from general relativistic magnetohydrodynamic (GRMHD) simulations, we identify a subset of physical models that can explain critical features of the polarimetric EHT observations while producing a relativistic jet of sufficient power. The consistent GRMHD models are all of magnetically arrested accretion disks, where near-horizon magnetic fields are dynamically important. We use the models to infer a mass accretion rate onto the black hole in M87 of (3-20) 10-4 M o˙ yr-1. © 2021. The Author(s). Published by the American Astronomical Society..

In 2017, the Event Horizon Telescope (EHT) Collaboration succeeded in capturing the first direct image of the center of the M87 galaxy. The asymmetric ring morphology and size are consistent with theoretical expectations for a weakly accreting supermassive black hole of mass ∼6.5 × 109 M o˙. The EHTC also partnered with several international facilities in space and on the ground, to arrange an extensive, quasi-simultaneous multi-wavelength campaign. This Letter presents the results and analysis of this campaign, as well as the multi-wavelength data as a legacy data repository. We captured M87 in a historically low state, and the core flux dominates over HST-1 at high energies, making it possible to combine core flux constraints with the more spatially precise very long baseline interferometry data. We present the most complete simultaneous multi-wavelength spectrum of the active nucleus to date, and discuss the complexity and caveats of combining data from different spatial scales into one broadband spectrum. We apply two heuristic, isotropic leptonic single-zone models to provide insight into the basic source properties, but conclude that a structured jet is necessary to explain M87's spectrum. We can exclude that the simultaneous γ-ray emission is produced via inverse Compton emission in the same region producing the EHT mm-band emission, and further conclude that the γ-rays can only be produced in the inner jets (inward of HST-1) if there are strongly particle-dominated regions. Direct synchrotron emission from accelerated protons and secondaries cannot yet be excluded. © 2021. The Author(s). Published by the American Astronomical Society..

Our understanding of strong gravity near supermassive compact objects has recently improved thanks to the measurements made by the Event Horizon Telescope (EHT). We use here the M87∗ shadow size to infer constraints on the physical charges of a large variety of nonrotating or rotating black holes. For example, we show that the quality of the measurements is already sufficient to rule out that M87∗ is a highly charged dilaton black hole. Similarly, when considering black holes with two physical and independent charges, we are able to exclude considerable regions of the space of parameters for the doubly-charged dilaton and the Sen black holes. © 2021 authors. Published by the American Physical Society.

Very-long-baseline interferometry (VLBI) observations of active galactic nuclei at millimetre wavelengths have the power to reveal the launching and initial collimation region of extragalactic radio jets, down to 10–100 gravitational radii (rg ≡ GM/c2) scales in nearby sources1. Centaurus A is the closest radio-loud source to Earth2. It bridges the gap in mass and accretion rate between the supermassive black holes (SMBHs) in Messier 87 and our Galactic Centre. A large southern declination of −43° has, however, prevented VLBI imaging of Centaurus A below a wavelength of 1 cm thus far. Here we show the millimetre VLBI image of the source, which we obtained with the Event Horizon Telescope at 228 GHz. Compared with previous observations3, we image the jet of Centaurus A at a tenfold higher frequency and sixteen times sharper resolution and thereby probe sub-lightday structures. We reveal a highly collimated, asymmetrically edge-brightened jet as well as the fainter counterjet. We find that the source structure of Centaurus A resembles the jet in Messier 87 on ~500 rg scales remarkably well. Furthermore, we identify the location of Centaurus A’s SMBH with respect to its resolved jet core at a wavelength of 1.3 mm and conclude that the source’s event horizon shadow4 should be visible at terahertz frequencies. This location further supports the universal scale invariance of black holes over a wide range of masses5,6. © 2021, The Author(s).

We present the results from a full polarization study carried out with the Atacama Large Millimeter/submillimeter Array (ALMA) during the first Very Long Baseline Interferometry (VLBI) campaign, which was conducted in 2017 April in the λ3 mm and λ1.3 mm bands, in concert with the Global mm-VLBI Array (GMVA) and the Event Horizon Telescope (EHT), respectively. We determine the polarization and Faraday properties of all VLBI targets, including Sgr A∗, M87, and a dozen radio-loud active galactic nuclei (AGNs), in the two bands at several epochs in a time window of 10 days. We detect high linear polarization fractions (2%-15%) and large rotation measures (RM > 103.3-105.5 rad m-2), confirming the trends of previous AGN studies at millimeter wavelengths. We find that blazars are more strongly polarized than other AGNs in the sample, while exhibiting (on average) order-of-magnitude lower RM values, consistent with the AGN viewing angle unification scheme. For Sgr A∗ we report a mean RM of (-4.2 0.3) 105 rad m-2 at 1.3 mm, consistent with measurements over the past decade and, for the first time, an RM of (-2.1 0.1) 105 rad m-2 at 3 mm, suggesting that about half of the Faraday rotation at 1.3 mm may occur between the 3 mm photosphere and the 1.3 mm source. We also report the first unambiguous measurement of RM toward the M87 nucleus at millimeter wavelengths, which undergoes significant changes in magnitude and sign reversals on a one year timescale, spanning the range from -1.2 to 0.3 105 rad m-2 at 3 mm and -4.1 to 1.5 105 rad m-2 at 1.3 mm. Given this time variability, we argue that, unlike the case of Sgr A∗, the RM in M87 does not provide an accurate estimate of the mass accretion rate onto the black hole. We put forward a two-component model, comprised of a variable compact region and a static extended region, that can simultaneously explain the polarimetric properties observed by both the EHT (on horizon scales) and ALMA (which observes the combined emission from both components). These measurements provide critical constraints for the calibration, analysis, and interpretation of simultaneously obtained VLBI data with the EHT and GMVA. © 2021. The American Astronomical Society.

Realistic synthetic observations of theoretical source models are essential for our understanding of real observational data. In using synthetic data, one can verify the extent to which source parameters can be recovered and evaluate how various data corruption effects can be calibrated. These studies are important when proposing observations of new sources, in the characterization of the capabilities of new or upgraded instruments, and when verifying model-based theoretical predictions in a comparison with observational data. We present the SYnthetic Measurement creator for long Baseline Arrays (SYMBA), a novel synthetic data generation pipeline for Very Long Baseline Interferometry (VLBI) observations. SYMBA takes into account several realistic atmospheric, instrumental, and calibration effects. We used SYMBA to create synthetic observations for the Event Horizon Telescope (EHT), a mm VLBI array, which has recently captured the first image of a black hole shadow. After testing SYMBA with simple source and corruption models, we study the importance of including all corruption and calibration effects. Based on two example general relativistic magnetohydrodynamics (GRMHD) model images of M87, we performed case studies to assess the attainable image quality with the current and future EHT array for different weather conditions. The results show that the effects of atmospheric and instrumental corruptions on the measured visibilities are significant. Despite these effects, we demonstrate how the overall structure of the input models can be recovered robustly after performing calibration steps. With the planned addition of new stations to the EHT array, images could be reconstructed with higher angular resolution and dynamic range. In our case study, these improvements allowed for a distinction between a thermal and a non-thermal GRMHD model based on salient features in reconstructed images., Comment: 20 pages, 15 figures, accepted for publication in A&A

Shin Takayanagi,1 Naoko Kawata,1 Yuji Tada,1 Jun Ikari,1 Yukiko Matsuura,1 Shin Matsuoka,2 Shoichiro Matsushita,2 Noriyuki Yanagawa,1 Yasunori Kasahara,1 Koichiro Tatsumi1 1Department of Respirology, Graduate School of Medicine, Chiba University, Inohana, Chuo-ku, Chiba-shi, Chiba, 2Department of Radiology, St Marianna University School of Medicine, Sugao, Miyamae-ku, Kawasaki-shi, Kanagawa, Japan Background: Recent advances in multidetector computed tomography (MDCT) facilitate acquiring important clinical information for managing patients with COPD. MDCT can detect the loss of lung tissue associated with emphysema as a low-attenuation area (LAA) and the thickness of airways as the wall area percentage (WA%). The percentage of small pulmonary vessels

We present {HCN} J=4\to 3 and {HCO}}+ J=4\to 3 maps of six nearby star-forming galaxies, NGC 253, NGC 1068, IC 342, M82, M83, and NGC 6946, obtained with the James Clerk Maxwell Telescope as part of the MALATANG survey. All galaxies were mapped in the central 2′ × 2′ region at 14″ (FWHM) resolution (corresponding to linear scales of ̃0.2-1.0 kpc). The L IR-L′dense relation, where the dense gas is traced by the {HCN} J=4\to 3 and the {HCO}}+ J=4\to 3 emission, measured in our sample of spatially resolved galaxies is found to follow the linear correlation established globally in galaxies within the scatter. We find that the luminosity ratio, L IR/L′dense, shows systematic variations with L IR within individual spatially resolved galaxies, whereas the galaxy-integrated ratios vary little. A rising trend is also found between L IR/L′dense ratio and the warm-dust temperature gauged by the 70 μm/100 μm flux ratio. We find that the luminosity ratios of IR/HCN (4-3) and IR/HCO+ (4-3), which can be taken as a proxy for the star formation efficiency (SFE) in the dense molecular gas (SFEdense), appear to be nearly independent of the dense gas fraction (f dense) for our sample of galaxies. The SFE of the total molecular gas (SFEmol) is found to increase substantially with f dense when combining our data with those on local (ultra)luminous infrared galaxies and high-z quasars. The mean L{{\prime} }HCN(4{--}3)}/L{{\prime} }HCO}+(4{--}3)} line ratio measured for the six targeted galaxies is 0.9 ± 0.6. No significant correlation is found for the L{{\prime} }HCN(4{--}3)}/L{{\prime} }HCO}+(4{--}3)} ratio with the star formation rate as traced by L IR, nor with the warm-dust temperature, for the different populations of galaxies.

The activity of the perioral muscles during breastfeeding in infants was investigated using EMGs. Fifty-six infants aged from 1 to 5 months were classified into five groups according to month of age in the cross-sectional study. Follow-up was carried out on 18 infants whose mean age was 2.5 months at the initial examination, and 4.8 months at the second. During suckling, EMGs were recorded unilaterally from the temporalis (TM), the masseter (MM), the orbicularis oris (OM), and the suprahyoid (SM) muscle groups. The activity of the SM increased significantly with age, while there was no appreciable increase in the activity of the TM, MM, and OM in either the cross-sectional study or the follow-up. However, total muscle activity was shown to increase significantly in both parts of the study. These findings suggest that the active tongue- and jaw-lowering movement may play a primary role in increasing sucking strength during the suckle-feeding period in infants.

Many practical clinical questions regarding the management of human immunodeficiency virus (HIV)- associated neurocognitive disorder (HAND) remain unanswered. We sought to identify and develop practical answers to key clinical questions in HAND management. Sixty-six specialists from 30 countries provided input into the program, which was overseen by a steering committee. Fourteen questions were rated as being of greatest clinical importance. Answers were drafted by an expert group based on a comprehensive literature review. Sixty-three experts convened to determine consensus and level of evidence for the answers. Consensus was reached on all answers. For instance, good practice suggests that all HIV patients should be screened for HAND early in disease using standardized tools. Follow-up frequency depends on whether HAND is already present or whether clinical data suggest risk for developing HAND. Worsening neurocognitive impairment may trigger consideration of antiretroviral modification when other causes have been excluded. The Mind Exchange program provides practical guidance in the diagnosis, monitoring, and treatment of HAND.

A major goal of the Atacama Large Millimeter/submillimeter Array (ALMA) is to make accurate images with resolutions of tens of milliarcseconds, which at submillimeter (submm) wavelengths requires baselines up to ~15 km. To develop and test this capability, a Long Baseline Campaign (LBC) was carried out from September to late November 2014, culminating in end-to-end observations, calibrations, and imaging of selected Science Verification (SV) targets. This paper presents an overview of the campaign and its main results, including an investigation of the short-term coherence properties and systematic phase errors over the long baselines at the ALMA site, a summary of the SV targets and observations, and recommendations for science observing strategies at long baselines. Deep ALMA images of the quasar 3C138 at 97 and 241 GHz are also compared to VLA 43 GHz results, demonstrating an agreement at a level of a few percent. As a result of the extensive program of LBC testing, the highly successful SV imaging at long baselines achieved angular resolutions as fine as 19 mas at ~350 GHz. Observing with ALMA on baselines of up to 15 km is now possible, and opens up new parameter space for submm astronomy., 11 pages, 7 figures, 2 tables; accepted for publication in the Astrophysical Journal Letters; this version with small changes to affiliations

We present Atacama Large Millimeter/submillimeter Array (ALMA) 1.3 mm continuum images of the asteroid 3 Juno obtained with an angular resolution of 0.042 arcseconds (60 km at 1.97 AU). The data were obtained over a single 4.4 hr interval, which covers 60% of the 7.2 hr rotation period, approximately centered on local transit. A sequence of ten consecutive images reveals continuous changes in the asteroid's profile and apparent shape, in good agreement with the sky projection of the three-dimensional model of the Database of Asteroid Models from Inversion Techniques. We measure a geometric mean diameter of 259pm4 km, in good agreement with past estimates from a variety of techniques and wavelengths. Due to the viewing angle and inclination of the rotational pole, the southern hemisphere dominates all of the images. The median peak brightness temperature is 215pm13 K, while the median over the whole surface is 197pm15 K. With the unprecedented resolution of ALMA, we find that the brightness temperature varies across the surface with higher values correlated to the subsolar point and afternoon areas, and lower values beyond the evening terminator. The dominance of the subsolar point is accentuated in the final four images, suggesting a reduction in the thermal inertia of the regolith at the corresponding longitudes, which are possibly correlated to the location of the putative large impact crater. These results demonstrate ALMA's potential to resolve thermal emission from the surface of main belt asteroids, and to measure accurately their position, geometric shape, rotational period, and soil characteristics., 8 pages, 3 figures, 2 tables, accepted for publication in the Astrophysical Journal Letters

We present Atacama Large Millimeter/submillimeter Array (ALMA) observations from the 2014 Long Baseline Campaign in dust continuum and spectral line emission from the HL Tau region. The continuum images at wavelengths of 2.9, 1.3, and 0.87 mm have unprecedented angular resolutions of 0.075 arcseconds (10 AU) to 0.025 arcseconds (3.5 AU), revealing an astonishing level of detail in the circumstellar disk surrounding the young solar analogue HL Tau, with a pattern of bright and dark rings observed at all wavelengths. By fitting ellipses to the most distinct rings, we measure precise values for the disk inclination (46.72pm0.05 degrees) and position angle (+138.02pm0.07 degrees). We obtain a high-fidelity image of the 1.0 mm spectral index ($\alpha$), which ranges from $\alpha\sim2.0$ in the optically-thick central peak and two brightest rings, increasing to 2.3-3.0 in the dark rings. The dark rings are not devoid of emission, we estimate a grain emissivity index of 0.8 for the innermost dark ring and lower for subsequent dark rings, consistent with some degree of grain growth and evolution. Additional clues that the rings arise from planet formation include an increase in their central offsets with radius and the presence of numerous orbital resonances. At a resolution of 35 AU, we resolve the molecular component of the disk in HCO+ (1-0) which exhibits a pattern over LSR velocities from 2-12 km/s consistent with Keplerian motion around a ~1.3 solar mass star, although complicated by absorption at low blue-shifted velocities. We also serendipitously detect and resolve the nearby protostars XZ Tau (A/B) and LkHa358 at 2.9 mm., Comment: 11 pages, 5 figures, 2 tables, accepted for publication in the Astrophysical Journal Letters

We present initial results of very high resolution Atacama Large Millimeter/submillimeter Array (ALMA) observations of the $z$=3.042 gravitationally lensed galaxy HATLAS J090311.6+003906 (SDP.81). These observations were carried out using a very extended configuration as part of Science Verification for the 2014 ALMA Long Baseline Campaign, with baselines of up to 15 km. We present continuum imaging at 151, 236 and 290 GHz, at unprecedented angular resolutions as fine as 23 milliarcseconds (mas), corresponding to an un-magnified spatial scale of ~180 pc at z=3.042. The ALMA images clearly show two main gravitational arc components of an Einstein ring, with emission tracing a radius of ~1.5". We also present imaging of CO(10-9), CO(8-7), CO(5-4) and H2O line emission. The CO emission, at an angular resolution of ~170 mas, is found to broadly trace the gravitational arc structures but with differing morphologies between the CO transitions and compared to the dust continuum. Our detection of H2O line emission, using only the shortest baselines, provides the most resolved detection to date of thermal H2O emission in an extragalactic source. The ALMA continuum and spectral line fluxes are consistent with previous Plateau de Bure Interferometer and Submillimeter Array observations despite the impressive increase in angular resolution. Finally, we detect weak unresolved continuum emission from a position that is spatially coincident with the center of the lens, with a spectral index that is consistent with emission from the core of the foreground lensing galaxy., Comment: 9 pages, 5 figures and 3 tables, accepted for publication in the Astrophysical Journal Letters

The use of persons who become alcoholic despite having a well-defined negative risk for alcoholism (inactive aldehyde dehydrogenase-2 or ALDH2) is advantageous in genetic research because of this population's reduced heterogeneity and possible genetic factors conferring susceptibility to alcohol dependence. This investigation of central serotonin neurotransmission, specifically the serotonin 1B (5HT1B) receptor gene and its role in both regulating alcohol consumption and developing alcohol dependence revealed overrepresentation of the C allele of the 861G>C polymorphism of 5HT1B in alcoholics with inactive ALDH2, compared with its frequency in nonalcoholic controls. No significant differences in 5HT1B genotype and allele distributions were observed between alcoholics with active ALDH2 and controls, however. Taken together with recent observations, these results suggest that genetic variability of the 5HT1B receptor is involved in the development of some type of alcohol dependence.

A 12-m diameter radio telescope will be deployed to the Summit Station in Greenland to provide direct confirmation of a Super Massive Black Hole (SMBH) by observing its shadow image in the active galaxy M87. The telescope (Greenland Telescope: GLT) is to become one of the Very Long Baseline Interferometry (VLBI) stations at sub-millimeter (submm) regime, providing the longest baseline > 9,000 km to achieve an exceptional angular resolution of 20 micro arc sec at 350 GHz, which will enable us to resolve the shadow size of ~40 micro arc sec. The triangle with the longest baselines formed by the GLT, the Atacama Large Millimeter/submillimeter Array (ALMA) in Chile, and the Submillimeter Array (SMA) in Hawaii will play a key role for the M87 observations. We have been working on the image simulations based on realistic conditions for a better understanding of the possible observed images. In parallel, retrofitting of the telescope and the site developments are in progress. Based on three years of opacity monitoring at 225 GHz, our measurements indicate that the site is excellent for submm observations, comparable to the ALMA site. The GLT is also expected to make single-dish observations up to 1.5 THz., 15 pages, 6 figures, accepted by Radio Science journal

The GLT project is deploying a new submillimeter (submm) VLBI station in Greenland. Our primary scientific goal is to image a shadow of the supermassive black hole (SMBH) of six billion solar masses in M87 at the center of the Virgo cluster of galaxies. The expected SMBH shadow size of 40-50 μas requires superbly high angular resolution, suggesting that the submm VLBI would be the only way to obtain the shadow image. The Summit station in Greenland enables us to establish baselines longer than 9,000 km with ALMA in Chile and SMA in Hawaii as well as providing a unique u–v coverage for imaging M87. Our VLBI network will achieve a superior angular resolution of about 20 μas at 350 GHz, corresponding to ∼ 2.5 times of the Schwarzschild radius of the supermassive black hole in M87. We have been monitoring the atmospheric opacity at 230 GHz since August. 2011; we have confirmed the value on site during the winter season is comparable to the ALMA site thanks to high altitude of 3,200 m and low temperature of −50°C. We will report current status and future plan of the GLT project towards our expected first light on 2015–2016.

The GLT project is deploying a new submillimeter (submm) VLBI station in Greenland. Our primary scientific goal is to image a shadow of the supermassive black hole (SMBH) of six billion solar masses in M87 at the center of the Virgo cluster of galaxies. The expected SMBH shadow size of 40-50 $\mu$as requires superbly high angular resolution, suggesting that the submm VLBI would be the only way to obtain the shadow image. The Summit station in Greenland enables us to establish baselines longer than 9,000 km with ALMA in Chile and SMA in Hawaii as well as providing a unique $u$--$v$ coverage for imaging M87. Our VLBI network will achieve a superior angular resolution of about 20 $\mu$as at 350 GHz, corresponding to $\sim2.5$ times of the Schwarzschild radius of the supermassive black hole in M87. We have been monitoring the atmospheric opacity at 230 GHz since August. 2011; we have confirmed the value on site during the winter season is comparable to the ALMA site thanks to high altitude of 3,200 m and low temperature of $-50\degr$C. We will report current status and future plan of the GLT project towards our expected first light on 2015--2016., Comment: 4 pages, 5 figures; to appear in the conference proceedings of "Innermost Regions of Relativistic Jets and Their Magnetic Fields", June 10-14, 2013, Granada, Spain

We present high angular resolution (0.5-2.0") observations of the mm continuum and the 12CO(J=3-2), 13CO(J=3-2), 13CO(J=2-1), C18O(J=2-1), HCN(J=3-2), HCO+(J=4-3) and HCO+(J=3-2) line emission in the circumnuclear disk (r=100pc) of the proto-typical Seyfert type-2 galaxy NGC1068, carried out with the Submillimeter Array. We further include in our analysis new 13CO(J=1-0) and improved 12CO(J=2-1) observations of NGC1068 at high angular resolution (1.0-2.0") and sensitivity, conducted with the IRAM Plateau de Bure Interferometer. Based on the complex dynamics of the molecular gas emission indicating non-circular motions in the central ~100pc, we propose a scenario in which part of the molecular gas in the circumnuclear disk of NGC1068 is radially blown outwards as a result of shocks. This shock scenario is further supported by quite warm (Tkin>=200K) and dense (nH2=10^4cm^-3) gas constrained from the observed molecular line ratios. The HCN abundance in the circumnuclear disk is found to be [HCN]/[12CO]=10^-3.5. This is slightly higher than the abundances derived for galactic and extragalactic starforming/starbursting regions. This results lends further support to X-ray enhanced HCN formation in the circumnuclear disk of NGC1068, as suggested by earlier studies. The HCO+ abundance ([HCO+]/[12CO]=10^-5) appears to be somewhat lower than that of galactic and extragalactic starforming/starbursting regions. When trying to fit the cm to mm continuum emission by different thermal and non-thermal processes, it appears that electron-scattered synchrotron emission yields the best results while thermal free-free emission seems to over-predict the mm continuum emission., accepted for publication by ApJ; 35pages, 22 figures and 6 tables (at the end of the file); 3 figures have been decreased in quality to match size limit

In the last two decades high resolution (< 5 arcsec) CO observations for ~ 150 galaxies have provided a wealth of information about the molecular gas morphologies in the circumnuclear regions. While in samples of 'normal' galaxies the molecular gas does not seem to peak toward the nuclear regions for about 50% of the galaxies, barred galaxies and mergers show larger concentrations. However, we do not exactly know from an observational point of view how the molecular gas properties of a galaxy evolve as a result of an interaction. Here we present the SMA CO(2-1) B0DEGA (Below 0 DEgree GAlaxies) legacy project in which we are imaging the CO(2-1) line of the circumnuclear regions (1 arcmin) of a large (~ 70) sample of nearby IR-bright spiral galaxies, likely interacting, and that still remained unexplored due to its location in the southern hemisphere. We find different molecular gas morphologies, such as rings, nuclear arms, nuclear bars and asymmetries. We find a centrally peaked concentration in about 85% of the galaxies with typical size scales of about 0.5 - 1 kpc. This might be related to perturbations produced by recent interactions., 7 pages, 4 figures, talk presented at "Galaxies and their Masks", celebrating Ken Freeman's 70-th birthday, Sossusvlei, Namibia, April 2010. To be published by Springer, New York, editors D.L. Block, K.C. Freeman, & I. Puerari

A time projection chamber (TPC) is a strong candidate for the central tracker of the international linear collider (ILC) experiment and we have been conducting a series of cosmic ray experiments under a magnetic field up to 4 T, using a small prototype TPC with a replaceable readout device: multi-wire proportional chamber (MWPC) or gas electron multiplier (GEM). We first confirmed that the MWPC readout could not be a fall-back option of the ILC-TPC under a strong axial magnetic field of 4 T since its spatial resolution suffered severely from the so called E x B effect in the vicinity of the wire planes. The GEM readout, on the other hand, was found to be virtually free from the E x B effect as had been expected and gave the resolution determined by the transverse diffusion of the drift electrons (diffusion limited). Furthermore, GEMs allow a wider choice of gas mixtures than MWPCs. Among the gases we tried so far a mixture of Ar-CF4-isobutane, in which MWPCs could be prone to discharges, seems promising as the operating gas of the ILC-TPC because of its small diffusion constant especially under a strong magnetic field. We report the measured drift properties of this mixture including the diffusion constant as a function of the electric field and compare them with the predictions of Magboltz. Also presented is the spatial resolution of a GEM-based ILC-TPC estimated from the measurement with the prototype., 4 pages, 8 figures. Preprint submitted to TIPP09 Proceedings

Presented by V. Lepeltier

We present the first interferometric CO(J=3-2) observations (beam size of 3.9"x1.6" or 160pc x 65pc) with the Submillimeter Array (SMA) toward the center of the Seyfert 2 galaxy M51. The image shows a strong concentration at the nucleus and weak emission from the spiral arm to the northwest. The integrated intensity of the central component in CO(J=3-2) is almost twice as high as that in CO(J=1-0), indicating that the molecular gas within an ~80 pc radius of the nucleus is warm (>~100 K) and dense (~10^4 cm^-3). Similar intensity ratios are seen in shocked regions in our Galaxy, suggesting that these gas properties may be related to AGN or starburst activity. The central component shows a linear velocity gradient (~1.4 km/s/pc) perpendicular to the radio continuum jet, similar to that seen in previous observations and interpreted as a circumnuclear molecular disk/torus around the Seyfert 2 nucleus. In addition, we identify a linear velocity gradient (~0.7 km/s/pc) along the jet. Judging from the energetics, the velocity gradient can be explained by supernova explosions or energy and momentum transfer from the jet to the molecular gas via interaction, which is consistent with the high intensity ratio., 12 pages, 3 figures, accepted for publication in ApJL

We present imaging observations of the evolved star IRC+10216 in the CS J=14--13 line at 685.4 GHz and associated submillimeter continuum at about 2'' resolution made with the partially constructed Submillimeter Array. The CS J=14--13 line emission from the stellar envelope is well resolved both spatially and spectrally. The strong central concentration of the line emission provides direct evidence that CS is a parent molecule that forms close to the stellar photosphere, in accord with previous images of the lower excitation CS J=2--1 line and inferences from unresolved observations of vibrationally excited transitions. The continuum emission is dominated by a compact, unresolved component, consistent with the photospheric emission, that accounts for about 20% of the broadband 450 micron flux. These are the first interferometer imaging observations made in the semi-transparent 450 micron atmospheric window., Comment: accepted for publication in ApJ Letters, 12 pages, 3 figures

We present results from observations of the most famous starburst galaxy M82 with the High-Resolution Camera onboard the Chandra X-Ray Observatory. We found nine sources in the central 1' x 1' region, but no source was detected at the galactic center. Comparing the observations on 1999 October 28 and on 2000 January 20, we found four of the nine sources showed significant time variability. In particular, CXOM82J095550.2+694047, which is 9" away from the galactic center, showed extremely large time variability. We conclude that this source is the origin of the hard X-ray time variability of M82 detected with ASCA. Assuming a spectral shape obtained by the ASCA observation, its luminosity in the 0.5 -- 10 keV band changed from 1.2E40 erg/s on 1999 October 28 to 8.7E40 erg/s on 2000 January 20., 12 pages, 2 figures, accepted by ApJ Letters. See the press release on the medium-massive BH (http://chandra.harvard.edu/press/00_releases/press_091200.html)

We have performed high resolution CO(2-1), CO(1-0), HCN(1-0) and HCO+(1-0) observations of a "low star formation efficiency starburst galaxy" NGC 4527 with the Nobeyama Millimeter Array. The integrated intensity ratios, CO(2-1)/CO(1-0) and HCN(1-0)/CO(1-0), are found to be 0.6 +/- 0.05 and 0.06 +/- 0.007, respectively, at the center. These line ratios are smaller than those in prototypical starburst galaxies such as NGC 253 and M82, and we suggest that the fraction of dense molecular gas to the total molecular mass in the central a few kpc region of NGC 4527 is small. This fact may be responsible for the low star formation., Comment: 2 pages, 1 figure, to appear in the proccedings of Star Formation 1999

The Thirteenth East Asia-Pacific Conference on Structural Engineering and Construction (EASEC-13), September 11-13, 2013, Sapporo, Japan.

There is no doubt that HLA-DR molecules are acting as the products of HLA-linked immune response genes (Ir-genes), because (i) HLA-DR molecules are the restriction elements in the interaction between CD4+ helper T cells and antigen-presenting cells (APC) to respond to many antigens such as streptococcal cell wall antigen (SCW) (Nishimura & Sasazuki, 1983; Sone et al., 1985; Hizayama et al., 1986), schistosomal antigen (Sj) (Hirayama et al., 1987), Mycobacterium leprae antigen (ML) (Kikuchi et al., 1986) and so on; and (ii) anti-HLA-DR monoclonal antibodies completely abolish the immune response to those antigens (Nishimura & Sasazuki, 1983; Sone et al., 1985). However, genetic analysis of the immune response to those antigens in families or populations revealed that responsiveness is recessive and non-responsiveness to those antigens is a dominant genetic trait that is tightly linked to HLA (Sasazuki et al., 1980a, 1983; Watanabe et al., 1988). This is completely opposite to the situation under the Ir-gene control where responsiveness is dominant and non-responsiveness is recessive. In this paper, we report evidence of how we came across the concept of HLA-linked immune suppression genes (Is-genes) besides Ir-genes, and show evidence for the epistatic interaction between HLA-DR and DQ to determine the immune response to several antigens in humans.

This White Paper details the intentions and plans of the East Asian Very Long Baseline Interferometry (VLBI) community for pushing the frontiers of millimeter/submillimeter VLBI. To this end, we shall endeavor to actively promote coordinated efforts in the East Asia region. Our goal is to establish firm collaborations among the East Asia VLBI community in partnership with related institutes in North America and Europe and to expand existing global mm/submm VLBI arrays for (a) exploring the vicinity of black holes with an ultimate angular resolution down to 1~R$_{S}$ (Schwarzschild radius) and (b) investigating the dynamics of circumstellar gas in star-forming regions and late-type stars, and circumnuclear gas around active galactic nuclei (AGNs). In the first half of this White Paper, we highlight scientific accomplishments of the East Asia (EA) VLBI community. Various VLBI research results on M87, Sgr A*, blazars, narrow-line Seyfert~1 galaxies, and compact symmetric objects are described, and future visions of our VLBI science are briefly presented. Maser science of star formation, stellar evolution, and physics of accretion disks around AGNs are also discussed. A new vision for conducting multi-transition maser studies using mm/submm VLBI together with the Atacama Large Millimeter/Submillimeter Array (ALMA) is described. In the second half of this White Paper, we describe the EA community's vision for using mm/submm VLBI arrays in the framework or extended version of the Event Horizon Telescope (EHT) and the Global Millimeter VLBI Array (GMVA). The accomplishment of the aforementioned goal will maximize the overall scientific outcomes of mm/submm VLBI in the world., Comment: 93 pages, 54 figures. White Paper from East Asia VLBI community