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Anaplastic lymphoma kinase–negative anaplastic large cell lymphoma (ALK– ALCL) is an aggressive neoplasm of T-cell/null-cell lineage. The T-Cell Project is a global prospective cohort study that consecutively enrolled patients newly diagnosed with peripheral T-cell lymphoma, registered through a centralized computer database between September 2006 and February 2018. Of 1553 validated cases from 74 sites in 13 countries worldwide, 235 were reported as ALK– ALCL. The median age at diagnosis was 54 years (range, 18-89 years), with a male predominance (62%). Stage III to IV disease was identified in 71% of patients, bulky disease and bone marrow involvement were uncommon, and 66% of patients presented with a low (0-1) International Prognostic Index score. Of all treated patients, 85% received multiagent initial chemotherapy, and 8% were consolidated with autologous hematopoietic cell transplantation. The initial overall and complete response rates were 77% and 63%, respectively. After a median follow-up of 52 months (95% confidence interval [CI], 41-63), the median progression-free survival (PFS) and overall survival (OS) were 41 months (95% CI, 17-62) and 55 months (95% CI, 36-75), respectively. The 3- and 5-year PFS rates were 52% and 43%, and the 3- and 5-year OS rates were 60% and 49%. Treatments containing both anthracycline and etoposide were associated with superior OS (P = .05) but not PFS (P = .18). In this large prospective cohort study, outcomes comparable to those previously reported in the retrospective International Peripheral T-Cell Lymphoma Project were observed. The study underscores the need for introducing novel platforms for ALK– ALCL and establishes a benchmark for future clinical trials. This trial was registered at www.clinicaltrials.gov as #NCT01142674.

Makoto Saito,1 Masanobu Morioka,1 Ko Izumiyama,1 Akio Mori,1 Tatsuro Irie,1 Masanori Tanaka,1 Yoshihiro Matsuno21Department of Internal Medicine and Hematology, Aiiku Hospital, Sapporo, Japan; 2Department of Surgical Pathology, Hokkaido University Hospital, Sapporo, JapanAbstract: We report a case of Epstein–Barr virus (EBV)-positive ileal extraosseous plasmacytoma containing plasmablastic lymphoma components with CD20-positive lymph node involvement. A 34-year-old healthy Japanese male developed intussusception due to an ileal plasmacytoma. The lesion was positive for EBV-encoded small nuclear RNA in in situ hybridization, with the surrounding lymph nodes showing the expression of CD20. Tumor cells in the ileal and lymph node lesions contained high-grade malignant features compatible with plasmablastic lymphoma. Because his abdominal lymph nodes recurred 6 months after resection, he received six cycles of R-CHOP chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone), and had a complete remission. Although his case was complicated by acute promyelocytic leukemia, he has so far survived, recurrence-free, for more than 7.5 years after chemotherapy for extraosseous plasmacytoma.Keywords: ileal extraosseous plasmacytoma, plasmablastic lymphoma, Epstein–Barr virus (EBV), lymph node involvement, CD20, R-CHOP

Background: The International Peripheral T-cell Lymphoma Project was organized to better understand the T-cell and natural killer (NK) cell lymphomas, and our task is to present the clinicopathologic correlations and therapeutic results for adult T-cell leukemia/lymphoma (ATL). Patients and methods: Among 1153 patients with T-cell or NK cell lymphomas, 126 patients (9.6%) with ATL were represented in this project. All were categorized as aggressive ATL, i.e. acute or lymphoma type, and 87% fell into the lymphoma type. Results: The median age was 62 years and the male to female ratio was 1.2 : 1. Significant prognostic factors for overall survival (OS) by univariate analysis were the presence of B symptoms (P = 0.018), platelet count

Purpose Peripheral T-cell lymphoma (PTCL) and natural killer/T-cell lymphoma (NKTCL) are rare and heterogeneous forms of non-Hodgkin's lymphoma (NHL) that, in general, are associated with a poor clinical outcome. Patients and Methods A cohort of 1,314 cases of PTCL and NKTCL was organized from 22 centers worldwide, consisting of patients with previously untreated PTCL or NKTCL who were diagnosed between 1990 and 2002. Tissue biopsies, immunophenotypic markers, molecular genetic studies, and clinical information from consecutive patients at each site were reviewed by panels of four expert hematopathologists and classified according to the WHO classification. Results A diagnosis of PTCL or NKTCL was confirmed in 1,153 (87.8%) of the cases. The most common subtypes were PTCL not otherwise specified (NOS; 25.9%), angioimmunoblastic type (18.5%), NKTCL (10.4%), and adult T-cell leukemia/lymphoma (ATLL; 9.6%). Misclassification occurred in 10.4% of the cases including Hodgkin's lymphoma (3%), B-cell lymphoma (1.4%), unclassifiable lymphoma (2.8%), or a diagnosis other than lymphoma (2.3%). We found marked variation in the frequency of the various subtypes by geographic region. The use of an anthracycline-containing regimen was not associated with an improved outcome in PTCL-NOS or angioimmunoblastic type, but was associated with an improved outcome in anaplastic large-cell lymphoma, ALK positive. Conclusion The WHO classification is useful for defining subtypes of PTCL and NKTCL. However, expert hematopathology review is important for accurate diagnosis. The clinical outcome for patients with most of these lymphoma subtypes is poor with standard therapies, and novel agents and new modalities are needed to improve survival.

Escherichia (E..) coli, a common causative misroorganism in bacteremia, is a member of facultatively anaerobic bancilli that are able to reduce NO3- to NO2-. To determine whether NO2- production or NO3- reduction occurs during the growth of E.. Coli in blood cultures, NO2- and NO3- were directly and simultaneously neasured by capillary zone electrophoresis. The BACTEC 9240 (Becton Dickinson Diagostic Instrument Systems, USA) was used to culture E. coli cells in blood samples. The NO2- concentration in the medium (6.0±2.6 μM at 0 h) significantly increased at 8 h (ｐ < 0.0001) and lowered to 65.0±37.6 μM at 10h. The peak of NO2- production (9.2±o.7h) appeared earlier than the CO2 production (11.1±0.9h). Theree is no correlation between the peak time of NO2- production and the CO2 detection time (p > 0.05). These data give us an essential potentiality to use the NO2- and NO3- monitoring system for detecting the presence of E. coli cells.

The Whitham modulation equations for the parameters of a periodic solution are derived using the generalized Lagrangian approach for the case of damped Benjamin-Ono equation. The structure of the dispersive shock in internal wave in deep water is considered by this method., Comment: 8 pages, 4 figures

A new cancer cell line (Lu-165) producing a large amount of anti-diuretic hormone (ADH, 2.8 micrograms/g protein) was established from a 50-year-old small cell lung cancer patient presenting with a syndrome of inappropriate anti-diuretic hormone secretion. These cells grew well in serum-supplemented medium and during more than 100 passages they continued producing a large amount of this hormone. This cell line will be a useful tool for studies of the biochemistry and pathology of ADH-producing cancer.

To define surgically curable "early" adenocarcinoma in the periphery of the lung, we examined histopathologic prognostic factors in 56 cases of stage I mucinous, nonmucinous, and sclerosing bronchioloalveolar carcinomas less than 2 cm in diameter. The death rate 5 years after surgery was only 1.8%, but the recurrence rate within 5 years after surgery was 8.9%. In addition, there were two cases of recurrence more than 5 years after surgery. Vascular invasion (p0.05) and mitotic index (p0.01) were the most important determinants of prognosis, and there was no recurrence or death in cases showing grades 1 and 2 collagenization in fibrotic foci. These results indicate surgically curable stage I adenocarcinomas to be less than 2 cm in diameter and without vascular invasion, with a low mitotic index and grade 1 or 2 fibrotic scarring, although the significance of nuclear atypia as a prognostic factor remains to be clarified. It may be possible to improve the cure rate by postoperative adjuvant chemotherapy for "early" adenocarcinoma with vascular invasion, high mitotic index, higher scar grade, and probably a high degree of nuclear atypia.

In our previous report, we described a new fixation and paraffin-embedding method (the AMeX method) that preserves many of the antigens that are normally destroyed by routine formalin fixation. The current study was conducted to examine the preservation of high-molecular-weight DNA in tissues processed by this method. DNA was extracted from AMeX-processed tissue sections after deparaffinization by the same method as that used to extract DNA from fresh tissues. The total amounts of DNA extracted from 10 mg each in wet weight of AMeX-processed and fresh mouse liver tissues were identical. In tissues of malignant lymphoma, the total amount of spooled DNA extracted from 50 sections, each 20 microns thick, was about 8 micrograms/mm2. The electrophoretic pattern of DNA digested with restriction endonucleases on agarose gel from AMeX-processed tissue sections did not differ from that of fresh materials. Southern blot hybridization analysis also revealed that the mobility of specific DNA fragments was identical for AMeX-processed and fresh tissues. The AMeX method was thus proved to be a versatile multipurpose tissue-processing procedure, which is expected to provide important information regarding the correlation between morphology, phenotypic expression, and gene alteration.

A beta+-thalassemia mutation at codon 24 (GGT----GGA) was discovered in a Japanese; this is the third type of beta-thalassemia found in this population. The case, as well as the data from DNA sequencing analysis, are presented.

AS A MOCK-UP EXPERIMENT FOR THE EXPERIMENTAL FAST REACTOR "JOYO",ASTUDY HAS BEEN MADE OF THE BLANKET EFFECT ON NUCLEAR CHARACTERISTICS,ESPECIALLY CRITICAL MASS,FISSION RATE DISTRIBUTION AND B4C CONTROL RODWORTH USING FCA ASSEMBLIES V-3-B. THE BLANKETS USED IN THE EXPERIMENT AREAN OXYGEN-RICH BLANKET AND A SODIUM-RICH MOCK-UP BLANKET. DETAILED COM-PARISON OF THE EXPERIMENTAL RESULTS WITH THOSE OBTAINED IN THE CASE OFNATURAL URANIUM METAL BLANKET (ASSEMBLY V-3) IS GIVEN IN THIS REPORT., 著者所属: 日本原子力研究開発機構(JAEA)

MANY FAST CRITICAL ASSEMBLIES HAVE BEEN BUILT IN MANY COUNTRIES INTHE WORLD IN ORDER TO ACCUMULATE VALUABLE DATA ABOUT THE NUCLEARCHARACTERISTICS AND SAFETY OF THE FAST BREEDER REACTOR. THE EXPERI-MENTS ON THE DOPPLER REACTIVITY EFFECT ARE ALSO NOT THE EXCEPTIONALCASE AND HENCE ARE PERFORMED ENERGETICALLY AT EVERY RESEARCH LABORA-TORY. HOWEVER,ALMOST ALL THE MEASURING METHOD SO FAR EMPLOYED HAVEBEEN THE SAMPLE DOPPLER REACTIVITY METHODS,NAMELY,THOSE TO DETER-MINE THE REACTIVITY WORTH DIFFERENCE OF A HOT SAMPLE LOCATED AT THECENTER OF A CORE FROM THE SAME SAMPLE AT THE SAME LOCATION BUT INCOLD SITUATION.SEFOR(SOUTHWEST EXPERIMENTAL FAST OXIDE REACTOR)IS AN EXPERIMENTALFAST REACTOR,ONE OF THE MAIN PURPOSES OF WHICH IS THE STUDY OF THEWHOLE CORE DOPPLER REACTIVITY EFFECT WHICH HAS NOT BEEN ENOUGH STUDIEDUP TO NOW ON THE FAST CRITICAL ASSEMBLIES,AND A LOT OF DATA OBTAINEDFROM THE EXPERIMENTS PERFORMED ON SEFOR HAVE BEEN PUBLISHED.THE MAIN PURPOSE OF THE PRESENT WORK IS TO ESTABLISH THE MET, None