23 results on '"Marie Faruch-Bilfeld"'
Search Results
2. Contribution of the use of clavicle bone density in age estimation
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Ryan, Toutin, Marie Faruch, Bilfeld, Camille, Raspaud, Corisandre, Bec, Norbert, Telmon, Frederic, Savall, and Fabrice, Dedouit
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Male ,Bone Density ,Osteogenesis ,Age Determination by Skeleton ,Forensic Anthropology ,Humans ,Reproducibility of Results ,Female ,Clavicle ,Epiphyses ,Pathology and Forensic Medicine - Abstract
Age estimation is an essential element in the field of forensics and is also of judicial interest in forensic medicine of the living. Despite all the methods, age estimation is often imprecise with many biases, especially in mature individuals. The main objective of our study is to assess the correlation between age and computed tomography bone mineral density of the medial end of the clavicle. A sample of 180 chest multi-slice computed tomography scans without contrast injection performed in living individuals, with suspected respiratory infection, aged 15 to 100 years was used. Bone density measurement was performed on the medial meta-epiphyseal region of the clavicles. A significant negative correlation was found between bone density and age of individuals (p-value 0.05). The mean absolute error was calculated for men at 13.4 years and 13.1 years for women, which was associated with an absence of bias. Good precision of the estimate for both sexes was also calculated on a subgroup of individuals whose age was greater than 40 years, with average absolute errors of about 12 years, which was associated with an absence of relative error. In view of our preliminary results, the study of bone density of the medial end of the clavicle could be of interest in the estimation of age. Several studies will be necessary to evaluate the reproducibility of these results on independent bone samples and in the estimation of age in the living individual.
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- 2022
3. Revisiting idiopathic eosinophilic myositis: towards a clinical-pathological continuum from the muscle to the fascia and skin
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Cécile Fermon, Lola E R Lessard, Tanguy Fenouil, Alain Meyer, Marie Faruch-Bilfeld, Marie Robert, Verena Landel, Arnaud Hot, François-Jérôme Authier, Nathalie Streichenberger, and Laure Gallay
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Rheumatology ,Pharmacology (medical) - Abstract
Objectives Idiopathic inflammatory myopathies are mainly defined by inflammatory infiltrates within the muscle (lymphocytes and macrophages). Eosinophil muscle infiltration has been described in idiopathic eosinophilic myositis (IEM) and rarely in EF. This study aimed to further delineate the nosological frame of idiopathic eosinophil muscle infiltration through the exhaustive analysis of IEM and EF patients. Methods This multicentre retrospective case series included IEM patients diagnosed between 2000 and 2022. IEM inclusion criteria were eosinophilic muscle infiltration with myositis pathological features, after the exclusion of differential diagnoses. An additional group of EF patients diagnosed between 2016 and 2022 was constituted. Inclusion criteria were an EF diagnosis and fascia thickening with inflammatory infiltrate. Results A total of 20 IEM cases and 10 EF cases were included. The median (interquartile range) age at diagnosis was 65 (49–70) years; there were 18 males. Data analysis delineated four subgroups: focal EM (FEM, n = 3), diffuse EM (DEM, n = 6), eosinophilic myofasciitis (EMF, n = 11) and EF (n = 10). FEM represented a limited and benign form of myositis. DEM cases presented objective muscle impairment with eosinophilic muscle infiltration. EMF patients presented subjective muscle impairment (myalgia, 55%), fasciitis (on histology and/or imaging), eosinophilic muscle infiltration and frequent hypereosinophilia (55%). EF patients presented myalgia (50%), muscle lesions on histology with fascia-restricted inflammatory infiltrates with (60%) or without (40%) eosinophils. Conclusions The analysis of IEM and EF patient characteristics delineates four subgroups (FEM, DEM, EMF and EF) in terms of clinical, laboratory, imaging, pathological and outcome specificities, and proposes an adapted diagnostic and care management approach.
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- 2022
4. Prevalence and Detection of Meniscal Ramp Lesions in Pediatric Anterior Cruciate Ligament–Deficient Knees
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Camille Thevenin-Lemoine, Marie Faruch Bilfeld, Julie Vial, Isabelle Bernardini, Franck Accadbled, Daniel N’Dele, and Etienne Cavaignac
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Male ,medicine.medical_specialty ,Adolescent ,Anterior cruciate ligament reconstruction ,medicine.medical_treatment ,Anterior cruciate ligament ,Meniscal tears ,Physical Therapy, Sports Therapy and Rehabilitation ,Menisci, Tibial ,Cohort Studies ,Arthroscopy ,03 medical and health sciences ,0302 clinical medicine ,Prevalence ,medicine ,Humans ,Orthopedics and Sports Medicine ,Ramp lesion ,Anterior Cruciate Ligament ,Child ,030222 orthopedics ,medicine.diagnostic_test ,business.industry ,Anterior Cruciate Ligament Injuries ,Magnetic resonance imaging ,030229 sport sciences ,Magnetic Resonance Imaging ,Tibial Meniscus Injuries ,Surgery ,medicine.anatomical_structure ,Tears ,Female ,Knee injuries ,business - Abstract
Background: Anterior cruciate ligament (ACL) tears represent 13% of knee injuries in children. Medial meniscal tears are commonly associated with ACL ruptures. Ramp lesions correspond to posterior meniscocapsular tears of the medial meniscus. Depending on the study, the prevalence of ramp lesions is inconsistent. Purpose: To describe the prevalence of ramp lesions in children and adolescents and to investigate the sensitivity of magnetic resonance imaging (MRI) for diagnosing such lesions. Study Design: Cohort study (Diagnosis); Level of evidence, 3. Methods: We analyzed videos from arthroscopic ACL reconstruction (ACLR) in children. During these procedures, we systematically looked for potential ramp lesions. To do so, an arthroscope was passed through the intercondylar notch to visualize the posteromedial compartment. A needle was introduced at the site of a posteromedial portal to unfold the meniscocapsular junction to reveal any hidden meniscal tear. Surgical procedures were performed by 2 senior surgeons. Videos were blindly analyzed by a third surgeon. Preoperative MRIs were screened by 2 blinded, independent senior radiologists to look specifically for ramp lesions. Results: Videos of 50 consecutive arthroscopic ACLRs concerning 32 boys and 18 girls were analyzed. Mean age at surgery was 14.2 years (range, 8.5-17.6 years). A total of 14 ramp lesions (28%) in 8 boys and 6 girls were identified. In addition, there were 22 tears of the meniscal body in 20 patients (40%). Arthroscopic and MRI findings did not correlate. Among 14 arthroscopically diagnosed ramp lesions, only 8 were detected on the MRI. Conversely, 12 patients had a ramp lesion detected on the MRI, which could not be confirmed intraoperatively. The sensitivity of MRI was 57% and the positive predictive value was 40%. Conclusion: A meniscal ramp lesion was present in 14 of 50 children (28%) undergoing ACLR. MRI has a low sensitivity for diagnosis of ramp lesions in children. Careful exploration of the posteromedial compartment is strongly recommended. Overlooking such lesions during ACLR may contribute to ongoing instability and higher re-rupture rates in these young patients.
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- 2021
5. How to improve the performance of acetabulum fracture diagnoses: investigating the use of three-dimensional CT-scan reconstructions
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Camille Minet, Nicolas Reina, Gautier Gracia, Franck Lapègue, Nicolas Sans, and Marie Faruch-Bilfeld
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Male ,Observer Variation ,Fractures, Bone ,Hip Fractures ,Emergency Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Acetabulum ,Femur Head ,Tomography, X-Ray Computed - Abstract
The classification of acetabular fractures remains a challenge for the junior radiologist, although he is the first line of diagnosis in Emergency Department. The advantages of three-dimensional reconstructions have yet to be evaluated on a large scale.A total of 212 fractures were classified according to Letournel and Judet by a senior orthopaedic surgeon, a senior radiologist, and a resident radiologist. The CT scans were first analysed in 2D and then a second time using 2D + 3D reconstructions of the acetabulum excluding the femoral head.3D reconstructions improved correct classification not only for the radiologist resident (+ 5%) but also for senior radiologist and orthopaedist (+ 2 and + 3%). 3D reconstructions also more significantly improved the diagnoses of complex fractures (+ 8.3%) compared to simple fractures (+ 0.4%).3D reconstructions have improved the routine diagnosis of acetabular fractures, especially for junior radiologist or in cases of complex fractures.
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- 2022
6. Technical note: age estimation by using pubic bone densitometry according to a twofold mode of CT measurement
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Olivier Dubourg, Norbert Telmon, Marie Faruch-Bilfeld, F. Savall, and Pauline Saint-Martin
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Adult ,Male ,Adolescent ,Bone density ,Pubic symphysis ,Pathology and Forensic Medicine ,Correlation ,Bone Density ,Age Determination by Skeleton ,Hounsfield scale ,Linear regression ,medicine ,Humans ,Aged ,Retrospective Studies ,Aged, 80 and over ,Orthodontics ,business.industry ,Mode (statistics) ,Pubic Symphysis ,Reproducibility of Results ,Forensic anthropology ,Middle Aged ,medicine.anatomical_structure ,Linear Models ,Forensic Anthropology ,Female ,France ,Tomography, X-Ray Computed ,Densitometry ,business - Abstract
In forensic anthropology, age estimation is a major element in the determination of a biological profile and the identification of individuals. Thus, many anatomical structures have been studied, such as the pubic symphysis, which is a source of major interest due to its late maturation. One of the most well-known methods of assessment is the Suchey-Brooks (SB) system based on the morphological characteristics of the pubic symphysis. The aim of this study was to propose linear regression formulae in order to deduce chronological age from bone density, using both Hounsfield unit (HU), and mean bone density (mBD) values of the pubic symphysis. Moreover, we intended to test the reliability and then to explore the feasibility of using HU instead of mBD values for age estimation. We built retrospectively a reference sample of 400 pubic symphyses using computed tomography at a French hospital and a test sample of 120 pubic symphyses. Equations were created to establish linear regression models for age estimation. Inaccuracy and bias were calculated for individuals aged more or less than 40 years. We highlighted homogeneous mean absolute errors for both HU and mBD values, most of them being less than 10 years. Moreover, we reported a moderate overestimation for younger individuals and a very small underestimation for older individuals. This study proposes a correlation between the bone density and age of individuals with a valuable level of reliability. Finally, HU measurements seem to be suitable for linking bone density with the age of individuals in forensic practice.
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- 2020
7. Ultrasonography: an interesting imaging method for ligament assessment during the acute phase of closed elbow injuries
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Romain Bilger, Pierre Laumonerie, Hugo Barret, Franck Lapègue, Pierre Mansat, Nicolas Sans, and Marie Faruch-Bilfeld
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Elbow Joint ,Elbow ,Joint Dislocations ,Humans ,Radiology, Nuclear Medicine and imaging ,General Medicine ,Prospective Studies ,Collateral Ligaments ,Radius Fractures ,Elbow Injuries ,Ultrasonography - Abstract
To evaluate whether ultrasonography can be used to explore the medial and lateral ligament structures during the acute phase of a closed elbow injury.A single-center, prospective study performed between December 2019 and June 2020, including patients who suffered a radial head fracture or elbow dislocation. Two radiologists did a blinded analysis using ultrasonography of visibility, injury grade, and presence of bone avulsion for the radial collateral ligament (RCL), lateral ulnar collateral ligament (LUCL), annular ligament (AL), and anterior (MCLant) and posterior bundles (MCLpost) of the medial collateral ligament. The inter-rater agreement was calculated. The ultrasonography findings were compared with the intraoperative findings in the patients who subsequently underwent surgery.Forty patients were included (28 radial head fractures and 12 elbow dislocations). The inter-rater agreement was strong for all the study parameters (kappa between 0.65 and 1), except for the visibility of the LUCL (kappa 0.52) and the visibility and appearance of the MCLpost (kappa 0.54 and 0.47, respectively). The injured ligaments were thicker than their contralateral counterparts (p 0.05). In the 10 patients who underwent surgery, the radiological-surgical correlation was 100% for the RCL and medial ligaments and 70% for the LUCL.Ultrasonography is a reproducible examination that can be used to assess the damage to elbow ligaments during the acute phase following an injury. This examination could be incorporated into the exploration protocol for elbow injuries during the preoperative assessment and to adapt the treatment.
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- 2022
8. A deep learning tool without muscle-by-muscle grading to differentiate myositis from facio-scapulo-humeral dystrophy using MRI
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Vincent Fabry, Franck Mamalet, Anne Laforet, Mikael Capelle, Blandine Acket, Coralie Sengenes, Pascal Cintas, and Marie Faruch-Bilfeld
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Adult ,Male ,Radiological and Ultrasound Technology ,Myositis ,General Medicine ,Middle Aged ,Magnetic Resonance Imaging ,Muscular Dystrophy, Facioscapulohumeral ,Young Adult ,Deep Learning ,Humans ,Radiology, Nuclear Medicine and imaging ,Female ,Muscle, Skeletal ,Aged - Abstract
The purpose of this study was to assess the capabilities of a deep learning (DL) tool to discriminate between type 1 facioscapulo-humeral dystrophy (FSHD1) and myositis using whole-body muscle magnetic resonance imaging (MRI) examination without the need for visual grading of muscle signal changes.A total of 40 patients who underwent whole-body MRI examination that included T1-weighted and STIR sequences were included. There were 19 patients with proven FSHD1 (9 men, 10 women; mean age, 47.7 ± 18.0 [SD] years; age range: 20-72 years) and 21 patients with myositis fulfilling European Neuromuscular Centre criteria and European League Against Rheumatism and American College of Rheumatology criteria (11 men, 10 women; mean age, 59.3 ± 17.0 [SD]; age range: 19-78 years). Based on thigh, calf, and shoulder sections a supervised training of a neural network was performed and its diagnostic performance was studied using a 5-fold cross validation method and compared to the results obtained by two radiologists specialized in musculoskeletal imaging.The DL tool was able to differentiate FSHD1 from myositis with a correct classification percentage respectively of 69 % (95% CI: 39-99), 75% (95% CI: 48-100) and 77% (95% CI: 60-94) when thigh only, thigh and calf or the thigh, calf, and shoulder MR images were analyzed. The percentages of correct classification of the two radiologists for these later MR images were 38/40 (95%) and 35/40 (87.5%), respectively; with no differences with DL tool correct classification (P = 0.41 and P0.99, respectively). Among the seven patients who were misclassified by the radiologists, the DL tool correctly classified six of them.A DL tool was developed to discriminate between FSHD1 and myositis using whole-body MRI with performances equivalent to those achieved by two radiologists. This study provides a proof of concept of the effectiveness of a DL approach to distinguish between two myopathies using MRI with a small amount of data, and no prior muscle signal changes grading.
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- 2021
9. Prevalence of inflammatory posterior arch abnormalities on lumbar spine MRI in spondyloarthritis patients compared with low back pain patients
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Adeline Ruyssen-Witrand, Clément Geniez, Hélène Braun, Marie Faruch-Bilfeld, Alain Cantagrel, Nicolas Sans, Delphine Nigon, Arnaud Constantin, and Yannick Degboé
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Adult ,Male ,musculoskeletal diseases ,medicine.medical_specialty ,Arthritis ,030218 nuclear medicine & medical imaging ,Facet joint ,Costotransverse joint ,03 medical and health sciences ,0302 clinical medicine ,Spondylarthritis ,Prevalence ,medicine ,Edema ,Humans ,Radiology, Nuclear Medicine and imaging ,Spondylitis ,Retrospective Studies ,Neuroradiology ,Inflammation ,Lumbar Vertebrae ,medicine.diagnostic_test ,business.industry ,Sacroiliitis ,Magnetic resonance imaging ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Low back pain ,medicine.anatomical_structure ,Case-Control Studies ,030220 oncology & carcinogenesis ,Female ,Radiology ,medicine.symptom ,business ,Low Back Pain - Abstract
This study was conducted in order to compare the prevalence of inflammatory posterior arch abnormalities on lumbar spine MRI between axial spondyloarthritis (axSpA) patients and low back pain (LBP) patients. Patients—axSpA patients meeting the 2009 ASAS criteria and chronic LBP patients who had a lumbar spine MRI were selected. MRI—STIR and T1 sagittal images up to T8–T9 were reviewed by two experienced rheumatologists blinded to the diagnosis and clinical data to identify inflammatory posterior arch abnormalities. Analyses—The prevalence of inflammatory posterior arch abnormalities between axSpA and LBP patients was compared. Clinical data were compared in the axSpA group depending on whether or not inflammatory posterior arch abnormalities were present. Ninety-five patients were enrolled in each group. The prevalence of all inflammatory posterior arch abnormalities was the same in the axSpA and LBP groups (58% in the SpA group versus 70% in the LBP group, p = 0.1). However, differences in terms of the prevalence of costotransverse joint arthritis, pedicle oedema above L3 and transverse and spinous process oedema were observed between the two groups (axSpA 27% versus LBP 6%, p = 0.0004). Patients with inflammatory posterior arch abnormalities in the axSpA group had a longer disease duration (11 versus 8 years, p = 0.02), higher CRP levels (median 11 versus 3 mg/l, p = 0.0002) and higher prevalence of radiographic sacroiliitis (84 versus 47%, p = 0.001) compared to patients without inflammatory posterior arch abnormalities. Costotransverse arthritis, pedicle oedema and transverse process oedema are more frequent in axSpA patients than LBP patients, on lumbar spine MRI depicting TH9-S1. • MRI pedicle oedema above L3, transverse process oedema, spinous process oedema or costotransverse arthritis is more frequently observed in axial spondyloarthritis (SpA). • SpA patients with at least one MRI inflammatory lesion on the posterior arch had higher clinical activity scores and biological inflammation. • Facet joint arthritis was more common in patients with chronic low back pain.
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- 2019
10. Ovarian and peritoneal psammocarcinoma: Results of a multicenter study on 25 patients
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Jean-Baptiste Delhorme, Jordan Ohayon, Sébastien Gouy, Gerlinde Averous, Catherine Genestie, Léopold Gaichies, Olivier Glehen, Jean-Marc Guilloit, Denis Pezet, Francois Quenet, Gwenaël Ferron, Cécile Brigand, Philippe Morice, Charles Honoré, Julio Abba, Karine Abboud, Mohammad Alyami, Catherine Arvieux, Naoual Bakrin, Gisèle Balagué, Vincent Barrau, Houda Ben Rejeb, Jean-Marc Bereder, Isabelle Berton-Rigaud, Frédéric Bibeau, Isabelle Bonnefoy, Dominique Bouzard, Ivan Bricault, Sébastien Carrère, Cécile de Chaisemartin, Madleen Chassang, Anne Chevallier, Thomas Courvoisier, Peggy Dartigues, Anthony Dohan, Julien Dubreuil, Frédéric Dumont, Clarisse Eveno, Marie Faruch-Bilfeld, Juliette Fontaine, Laure Fournier, Johan Gagniere, Delphine Geffroy, Laurent Ghouti, François-Noël Gilly, Laurence Gladieff, Diane Goéré, Aymeric Guibal, Frédéric Guyon, Bruno Heyd, Christine Hoeffel, Constance Hordonneau, Sylvie Isaac, Peggy Jourdan-Enfer, Rachid Kaci, Reza Kianmanesh, Catherine Labbé-Devilliers, Joëlle Lacroix, Bernard Lelong, Agnès Leroux-Broussier, Yoann Lherm, Réa Lo Dico, Gérard Lorimier, Caroline Malhaire, Frédéric Marchal, Pascale Mariani, Emilie Mathiotte, Pierre Meeus, Eliane Mery, Simon Msika, Cédric Nadeau, Pablo Ortega-Deballon, Guillaume Passot, Olivier Pellet, Patrice Peyrat, Nicolas Pirro, Marc Pocard, Flora Poizat, Jack Porcheron, Anaïs Poulet, François Quenet, Patrick Rat, Pierre Rousselot, Pascal Rousset, Hélène Senellart, Martine Serrano, Vincent Servois, Olivia Sgabura, Andrea Skanjeti, Magali Svrcek, Raphaël Tetreau, Emilie Thibaudeau, Yann Touchefeu, Jean-Jacques Tuech, Séverine Valmary-Degano, Delphine Vaudoyer, Stéphane Velasco, Véronique Verriele-Beurrier, Laurent Villeneuve, Romuald Wernert, Franck Zinzindohoue, Département de chirurgie générale et digestive [CHU Strasbourg], Centre Hospitalier Universitaire de Strasbourg (CHU de Strasbourg ), Institut Gustave Roussy (IGR), Département de chirurgie gynécologique [Gustave Roussy], Service d'anatomie pathologique [CHU Pitié-Salpêtrière], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Université de Caen Normandie - UFR Santé (UNICAEN Santé), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Hôpital Nord, Hôpital nord, Service d'Oncologie Médicale [Centre hospitalier Lyon Sud - HCL], Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL), CHU Grenoble, Hôpitaux Universitaires de Strasbourg, Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UCA), Laboratoire d'anatomo-pathologie, CRLCC Val d'Aurelle - Paul Lamarque, Département de chirurgie, Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Centre hospitalier universitaire de Poitiers (CHU Poitiers), Département de biologie et pathologie médicales [Gustave Roussy], Department of Body and Interventional Imaging, Hôpital Lariboisière, Paris, France., Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université de Lille, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Toulouse [Toulouse], Institut Claudius Regaud, Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Chirurgie digestive et hépatobiliaire, CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Ciblage thérapeutique en Oncologie (EA3738), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Hospices Civils de Lyon (HCL), Département de chirurgie générale [Gustave Roussy], Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Service de chirurgie viscérale et digestive - Unité de transplantation hépatique, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre Hospitalier Universitaire de Reims (CHU Reims), Service de Radiologie, Service de pathologie, Service de Chirurgie Générale, Digestive et Endocrine [CHU Reims], Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, Service de Radiologie [CLCC Baclesse], Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN), Centre de recherches (CRT), Société Lafarge, Service de Chirurgie d'Oncologie Digestive [CHU Lariboisière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Paul Papin(Angers), Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre de Recherche en Automatique de Nancy (CRAN), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Institut Curie [Paris], Centre Léon Bérard [Lyon], Institut Claudius Regaud. Department of pathology, Hôpital Louis Mourier - AP-HP [Colombes], Department of Gynecology and Obstetrics, Lipides - Nutrition - Cancer (U866) (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), Service de Chirurgie Digestive (AP-HM), Université de la Méditerranée - Aix-Marseille 2, Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Service de Biopathologie [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Chirurgie digestive, Centre Hospitalier Universitaire de Saint-Etienne, Laboratoire Joliot Curie, École normale supérieure - Lyon (ENS Lyon)-Centre National de la Recherche Scientifique (CNRS), CRLC Val d'Aurelle-Paul Lamarque, Service de Chirurgie Digestive, Cancérologique, Générale, Endocrinienne et Urgences (CHU de Dijon), Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Laboratoire d'Anatomie Pathologique, CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Department of Radiology, Centre René Gauducheau, CRLCC René Gauducheau, Université de Lyon, (le programme) Cartes d'identité des tumeurs (CIT), Ligue Nationales Contre le Cancer (LNCC), Institut du Cancer de Montpellier (ICM), Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), Laboratoire d'éthique médicale et médecine légale (LEM), Université Paris Descartes - Paris 5 (UPD5), Service de Pathologie, Centro de Investigaciones Oceanograficas e Hidrograficas (CIOH), DIMAR, Ministerio de Defensa Nacional, Colombie, Unité de Méthodologie en Recherche Clinique, Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL), Service de chirurgie digestive, générale et cancérologique [CHU HEGP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), École normale supérieure de Lyon (ENS de Lyon)-Centre National de la Recherche Scientifique (CNRS), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), and Université Paris Diderot - Paris 7 (UPD7)-Hôpital Lariboisière-Fernand-Widal [APHP]
- Subjects
Hyperthermic Intraperitoneal Chemotherapy ,Intraperitoneal chemotherapy ,chemistry.chemical_compound ,0302 clinical medicine ,Infusions, Parenteral ,Peritoneal Neoplasms ,Ovarian Neoplasms ,Univariate analysis ,030219 obstetrics & reproductive medicine ,General Medicine ,Cytoreduction Surgical Procedures ,Middle Aged ,Neoadjuvant Therapy ,Progression-Free Survival ,3. Good health ,Survival Rate ,medicine.anatomical_structure ,Oncology ,Chemotherapy, Adjuvant ,030220 oncology & carcinogenesis ,Female ,France ,Peritoneum ,Pancreas ,Adult ,medicine.medical_specialty ,Adolescent ,Ovary ,Antineoplastic Agents ,Psammocarcinoma ,03 medical and health sciences ,Young Adult ,medicine ,Humans ,Aged ,business.industry ,[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology ,[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology ,Carboplatin ,Surgery ,chemistry ,Multicenter study ,Conventional PCI ,Neoplasm Grading ,business ,Neoplasms, Cystic, Mucinous, and Serous ,Rare disease - Abstract
International audience; Purpose: Psammocarcinoma (PK) is a rare disease of unknown origin. We aimed to report the characteristics, management and survival of patients operated on for PK within the French Network for Rare Peritoneal Malignancies (RENAPE) expert centers.Patients and methods: All consecutive cases of PK operated within all 26 RENAPE centers between 1997 and 2018 were retrospectively analyzed.Results: Twenty-five patients were identified. The median age was 53 years [range 17–78]. None of the patients had extra peritoneal metastases at diagnosis. A median of 6 cycles of carboplatin-based systemic chemotherapy was delivered in 52% preoperatively (n = 13) and 56% postoperatively (n = 14); associated with placlitaxel for 12 patients. All patients were operated on. The median PCI was 23 [0–33]. Eighty-four percent had a complete cytoreductive surgery through digestive (n = 7), spleen (n = 3), pancreas (n = 1) resections and/or multiple peritonectomies (n = 11). Five patients (20%) had intraperitoneal chemotherapy. Morbidity (Dindo-Clavien ≥3) was 12%. No postoperative death occurred. After a median follow-up of 42 months (range [2–194]), the median overall (OS) and progression-free (DFS) survival times were respectively 128 months and 31 months. Eighteen patients recurred (72%), mainly in the peritoneum (n = 16). Four of them (22%) were reoperated. The 5 and 10-year DFS rates were both 20.3%. The 5 and 10-year OS rates were 62% and 51.7%, respectively. A complete cytoreductive surgery was associated with a better OS and DFS in a univariate analysis.Conclusion: Complete cytoreductive surgery is the cornerstone of the PK's management as a primary treatment. Recurrence remains common and new adjuvant strategies seem needed.
- Published
- 2019
11. Correlation between pubic bone mineral density and age from a computed tomography sample
- Author
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Olivier Dubourg, F. Savall, Marie Faruch-Bilfeld, Norbert Telmon, Estelle Maupoint, Pauline Saint-Martin, Anthropologie Moléculaire et Imagerie de Synthèse (AMIS), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université d'Angers (UA), Hôpital Pierre-Paul Riquet [Toulouse], CHU Toulouse [Toulouse], and Hôpital de Rangueil
- Subjects
Adult ,Male ,Bone density ,Dentistry ,Computed tomography ,Pubic symphysis ,Significant negative correlation ,01 natural sciences ,Pathology and Forensic Medicine ,[SHS]Humanities and Social Sciences ,Correlation ,03 medical and health sciences ,Imaging, Three-Dimensional ,0302 clinical medicine ,Bone Density ,Age Determination by Skeleton ,Multidetector Computed Tomography ,Humans ,Medicine ,030216 legal & forensic medicine ,Aged ,Pubic Bone ,Retrospective Studies ,Aged, 80 and over ,Bone mineral ,medicine.diagnostic_test ,business.industry ,010401 analytical chemistry ,Reproducibility of Results ,Forensic anthropology ,Middle Aged ,0104 chemical sciences ,medicine.anatomical_structure ,Forensic Anthropology ,Female ,business ,Law ,Kappa - Abstract
In forensic anthropology, the estimation of age at death is mainly required to establish a biological profile and facilitate individual identification. The Suchey–Brooks (SB) system represents one of the most commonly used and tested methods of assessment based on the morphological characteristics of the pubic symphysis. However, this method has certain drawbacks, including frequently inaccurate estimation for older individuals. The aim of this work was to test the evolution of pubic bone mineral density (BMD) according to age, especially for individuals over 40 years old. We retrospectively studied pubic bones from males (n = 88) and females (n = 113) over 40 years of age undergoing clinical multi-slice computed tomography (MSCT) in a French hospital between November 2017 and April 2018. The results revealed a significant negative correlation between BMD and age for males (R = −0.62) and females (R = −0.55). The intra- and inter-observer reliabilities of the phase allocation were moderate for males (kappa values at 0.72 and 0.65) and strong for females (kappa values at 0.93 and 0.86). Moreover, a significant difference in BMD between stages 6-1 and 6-2 for males was observed. We hypothesize that BMD might help improve the reliability of the SB system for older individuals. In addition to the pubic bone, numerous other anatomical regions such as the area of Ward could represent interesting areas of study in order to relate bone density to age.
- Published
- 2019
12. US-guided percutaneous release of the first extensor tendon compartment using a 21-gauge needle in de Quervain’s disease: a prospective study of 35 cases
- Author
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Marine Brunet, Christophe Borel, Ezin Jocelyn Akakpo, Olivia Constans, Pierre Laumonerie, Aymeric André, Hubert Basselerie, Marie Faruch-Bilfeld, Nicolas Sans, F. Lapègue, H. Chiavassa-Gandois, Etienne Pasquier Bernachot, Omar Lasfar, Université Toulouse III - Paul Sabatier - UT3 (FRANCE), Clinique Médipôle Garonne (FRANCE), Faculté de médecine du CNHU de Cotonou (BENIN), Centre Hospitalier Universitaire de Toulouse - CHU Toulouse (FRANCE), and Polyclinique Le Languedoc (FRANCE)
- Subjects
Adult ,Male ,medicine.medical_specialty ,Tendon Entrapment ,Percutaneous ,Visual analogue scale ,medicine.medical_treatment ,Tenotomy ,Médecine humaine et pathologie ,Injections, Intralesional ,Injections, intralesional ,Tendons ,03 medical and health sciences ,Retinaculum ,0302 clinical medicine ,Cadaver ,Adrenal Cortex Hormones ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,De Quervain disease ,Prospective Studies ,De Quervain Disease ,Ultrasonography, Interventional ,Aged ,Pain Measurement ,030203 arthritis & rheumatology ,030222 orthopedics ,Tenosynovitis ,business.industry ,General Medicine ,Middle Aged ,medicine.disease ,Surgery ,Patient Outcome Assessment ,Forearm ,Needles ,Tendon entrapment ,Female ,Ultrasonography, interventional ,Radiology ,business - Abstract
To evaluate the efficacy of ultrasonography-guided percutaneous treatment of de Quervain tenosynovitis with the combination of a corticosteroid injection and release of the retinaculum of the first extensor compartment tendons with a 21-gauge needle. The first part of our study consisted of ten procedures on cadaver wrists followed by dissection to analyse the effectiveness of the retinaculum release and detect any collateral damage. The second part was a prospective clinical study of 35 procedures. Outcomes were evaluated through a 6-month clinical follow-up and telephone interview at the end of the study. The following parameters were monitored over time: pain level on a visual analogue scale, the QuickDASH and the PRWE. Patient satisfaction questionnaires were also administered. No complications were found during the cadaver study. However, the release was confirmed as ‘partial’ in all wrists. In the clinical portion of this study, significant improvement was observed in 91.4 % of cases (32/35) within 1 month and the results were stable until the end of the study; all of these patients avoided surgery. The release procedure failed in three patients who eventually required surgical treatment. US-guided partial release and simultaneous corticosteroid injection for treatment of de Quervain’s disease using a 21-gauge needle is feasible in current practice, with minimal complications. • Ultrasound-guided treatment of de Quervain's disease is feasible with a 21G needle. • There was notable regression of clinical signs in 91.4 % of cases. • The procedure is very safe, no iatrogenic neurovascular or tendinous injuries occurred. • Our procedure requires only one session and 3 days away from work.
- Published
- 2018
13. Correlation between quantitative and semiquantitative magnetic resonance imaging and histopathology findings in dermatomyositis
- Author
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José César, Milisenda, María Victoria, Collado, Iago, Pinal-Fernandez, Andres, Hormaza Jaramillo, Marie, Faruch Bilfeld, María Dolores, Cano, Ana Isabel, García, Xavier, Tomás, and Josep María, Grau
- Subjects
Muscular Diseases ,Biopsy ,Edema ,Humans ,Muscle, Skeletal ,Magnetic Resonance Imaging ,Dermatomyositis - Abstract
The aim of this study was to compare muscle biopsy findings, as well as clinical and analytical features, with those of magnetic resonance imaging (MRI) studies of muscle in patients with dermatomyositis.All patients from the Longitudinal Myopathy Cohort of the Hospital Clínic de Barcelona were prospectively included in the study from 2009 to 2016. MRI images of muscle and fascial oedema were compared with muscle pathology results using both quantitative and semi-quantitative scores.We found a statistically significant association between the inflammatory infiltrate and both muscle (r2=0.54, p=0.001) and fascial oedema (r2=0.54, p0.001). In addition, muscle oedema was significantly associated with punched-out vacuoles (p=0.04) and muscle enzymes in serum (r2=0.34, p=0.01 for CK and r2=0.22, p0.05 for aldolase). The number of treatment drugs received at the time of MRI was inversely associated with the number of muscle inflammatory cells in the biopsy and with both muscle and fascial oedema (all p0.05).Key MRI findings correlate with the main features of dermatomyositis muscle biopsy results, suggesting that MRI findings could be used as a surrogate marker of disease activity.
- Published
- 2018
14. Geometric morphometric study of the early shape of the hip bone (os coxae): variations with age and sex
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Clotilde Lambeaux, Norbert Telmon, F. Dedouit, Etienne Cavaignac, Nicolas Sans, Frédéric Savall, and Marie Faruch Bilfeld
- Subjects
Male ,Sex Characteristics ,Ontogeny ,Age Factors ,Infant ,Anatomy ,Biology ,Age and sex ,Anthropology, Physical ,Sexual dimorphism ,medicine.anatomical_structure ,Imaging, Three-Dimensional ,Morphometric analysis ,Anthropology ,Hip bone ,Child, Preschool ,medicine ,Humans ,Female ,Bone shape ,Anatomic Landmarks ,Pelvic Bones ,Tomography, X-Ray Computed - Abstract
Data regarding sexual dimorphism in children are sparse with contradictory results. Recently, geometric morphometric analysis has shown that the pubis and ilium have both sexual shape dimorphism and shape differences that increase during ontogeny, but little is known about the entire pelvic (os coxae) bone shape in very young children. The goal of this study was to show pelvic bone age-related and sex-related shape changes using 3D geometric morphometric analysis in very young children. Geometric morphometric analysis was carried out on CT scans of the pelvic bone of 96 children aged from 3 to 24 months. Eleven landmarks were defined on the left pelvic bone. Geometric morphometric analyses were carried out to identify trends in bone shape in sex-based and age-based subgroups. Age-related differences in shape were statistically significant (Goodall's F = 3.68; p < 0.001) but there were no sex-related differences in shape (Goodall's F = 1.95; p = 0.065). Overall, the superior part of the pelvic bone becomes narrower with age. This study has shown that geometric morphometric analysis of the pelvic bone is feasible in very young children and revealed changes in shape with age but not differences with sex.
- Published
- 2018
15. Diagnostic value of cone beam computed tomography (CBCT) in occult scaphoid and wrist fractures
- Author
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Christophe Borel, F. Lapègue, Ahmed Larbi, Marie Faruch-Bilfeld, Stephanie Delclaux, Nicolas Sans, H. Chiavassa-Gandois, Centre Hospitalier Universitaire de Nîmes - CHU Nîmes (FRANCE), Centre Hospitalier Universitaire de Toulouse - CHU Toulouse (FRANCE), CHU Toulouse [Toulouse], Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), and Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)
- Subjects
Male ,Cone beam computed tomography ,Radiography ,Cost-Benefit Analysis ,Scaphoid fracture ,Wrist ,030218 nuclear medicine & medical imaging ,Fractures, Bone ,0302 clinical medicine ,Prospective Studies ,Fractures, Closed ,Prospective cohort study ,030222 orthopedics ,medicine.diagnostic_test ,General Medicine ,Cone-Beam Computed Tomography ,Middle Aged ,respiratory system ,Wrist Injuries ,Magnetic Resonance Imaging ,Occult fracture ,medicine.anatomical_structure ,Scaphoid bone ,Female ,Radiology ,Adult ,medicine.medical_specialty ,Adolescent ,Médecine humaine et pathologie ,Sensitivity and Specificity ,03 medical and health sciences ,Young Adult ,Magnetic resonance imaging ,Double-Blind Method ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Wrist fracture ,Aged ,Scaphoid Bone ,business.industry ,medicine.disease ,Occult ,business ,Nuclear medicine ,Radius Fractures ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
Objective Evaluate the diagnostic value of cone beam computed tomography (CBCT) for scaphoid and wrist fractures that are missed on standard radiographs. Materials and methods Between September 2014 and October 2015, we prospectively enrolled 49 patients with a clinically suspected scaphoid fracture following an acute injury but had normal radiographs. Each patients underwent radiographs, CBCT and (magnetic resonance imaging) MRI within 7 days of the initial injury event. Both exam were evaluated independently by two radiologists. Results For scaphoid cortical fractures CBCT sensitivity is 100% (95% CI: 75%–100%), specificity 97% (95% CI: 83%–100%). CBCT diagnosed all 24 corticals wrist fractures, corresponding to a sensitivity of 100% (95% CI: 83%–100%), specificity of 95% (95% CI: 75%–100%). Kappa agreement rate between the two radiologists was K = 0.95 (95% CI: 0.85–1) for scaphoid fractures and K = 0.87 (95% CI: 0.73–1) for wrist fractures. Conclusions CBCT is superior to radiographs for diagnosing occult cortical fractures. Because of its low radiation dose, we believe that CBCT can be used in current practice as a replacement or supplement to radiographs to detect these fractures and optimize the cost-effectiveness ratio by limiting the number of needless immobilizations.
- Published
- 2017
16. Metric Sex Determination of the Human Coxal Bone on a Virtual Sample using Decision Trees
- Author
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Daniel Rougé, Hervé Rousseau, Norbert Telmon, Frédéric Savall, F. Dedouit, Marie Faruch-Bilfeld, and Nicolas Sans
- Subjects
Adult ,Male ,Multivariate statistics ,Decision tree ,Pathology and Forensic Medicine ,Imaging, Three-Dimensional ,Multidetector Computed Tomography ,Statistics ,Genetics ,Humans ,Pelvic Bones ,Retrospective Studies ,Mathematics ,Training set ,business.industry ,Decision Trees ,Discriminant Analysis ,Forensic anthropology ,Sex Determination by Skeleton ,Linear discriminant analysis ,Test set ,Virtual sample ,Metric (mathematics) ,Forensic Anthropology ,Female ,Artificial intelligence ,Anatomic Landmarks ,business - Abstract
Decision trees provide an alternative to multivariate discriminant analysis, which is still the most commonly used in anthropometric studies. Our study analyzed the metric characterization of a recent virtual sample of 113 coxal bones using decision trees for sex determination. From 17 osteometric type I landmarks, a dataset was built with five classic distances traditionally reported in the literature and six new distances selected using the two-step ratio method. A ten-fold cross-validation was performed, and a decision tree was established on two subsamples (training and test sets). The decision tree established on the training set included three nodes and its application to the test set correctly classified 92% of individuals. This percentage was similar to the data of the literature. The usefulness of decision trees has been demonstrated in numerous fields. They have been already used in sex determination, body mass prediction, and ancestry estimation. This study shows another use of decision trees enabling simple and accurate sex determination.
- Published
- 2015
17. Ontogeny of Size and Shape Sexual Dimorphism in the Pubis: A Multislice Computed Tomography Study by Geometric Morphometry
- Author
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Marie Faruch, Bilfeld, Fabrice, Dedouit, Nicolas, Sans, Hervé, Rousseau, Daniel, Rougé, and Norbert, Telmon
- Subjects
Male ,Principal Component Analysis ,Adolescent ,Infant ,Sex Determination by Skeleton ,Pathology and Forensic Medicine ,Imaging, Three-Dimensional ,Age Determination by Skeleton ,Child, Preschool ,Multidetector Computed Tomography ,Genetics ,Forensic Anthropology ,Humans ,Female ,Child ,Pubic Bone ,Retrospective Studies - Abstract
Few studies have been conducted to determine sex differences in the immature coxal bone and the results were often contradictory. The authors studied sexual dimorphic differences of the pubis using geometric morphometric analysis of five osteometric landmarks recorded by multislice computed tomography (MSCT), based on three-dimensional reconstructions of 188 children (95 boys, 93 girls) living in the region of Toulouse, southwestern France, ranging in age from 1 to 18 years old. They used geometric morphometric methodology first to test sexual dimorphism in size (centroid size) and shape (Procrustes residuals) and second to examine patterns of shape change with age (development) and size change with age (growth). Based on statistical significance test results, the pubic shape became sexually dimorphic at 13 years old, although visible shape differences were observed as early as 9 years old. This work showed that the trajectories of pubis shape (development) and size (growth) differed throughout ontogeny and between sexes.
- Published
- 2015
18. Anterolateral ligament injuries in knees with an anterior cruciate ligament tear: Contribution of ultrasonography and MRI
- Author
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Nicolas Sans, Olivia Constans, F. Lapègue, Etienne Cavaignac, Ahmed Larbi, Karine Wytrykowski, Hélène Chiavassa Gandois, Marie Faruch Bilfeld, Hôpital Universitaire Carémeau [Nîmes] (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Centre Hospitalier Universitaire de Nîmes - CHU Nîmes (FRANCE), and Centre Hospitalier Universitaire de Toulouse - CHU Toulouse (FRANCE)
- Subjects
Anterolateral ligament ,Adult ,Male ,medicine.medical_specialty ,Knee Joint ,Radiography ,Anterior cruciate ligament ,Médecine humaine et pathologie ,Segond fracture ,030218 nuclear medicine & medical imaging ,Avulsion ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Neuroradiology ,Ultrasonography ,Rupture ,030222 orthopedics ,Anterior Cruciate Ligament Reconstruction ,business.industry ,Anterior Cruciate Ligament Injuries ,General Medicine ,Enthesis ,medicine.disease ,musculoskeletal system ,Magnetic Resonance Imaging ,Surgery ,medicine.anatomical_structure ,Tears ,Diagnostic imaging ,Female ,Radiology ,business ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology - Abstract
To describe the pathological appearance of the anterolateral ligament (ALL) on US and MRI in knees with an anterior cruciate ligament (ACL) tear. This prospective study included 30 patients who had a suspected acute ACL tear. Their injured and contralateral knees were evaluated with radiography, US and MRI. Two radiologists evaluated the ALL on the MRI and US examinations. Agreement between these examiners’ findings was evaluated with Cohen’s kappa. On US examination, the ALL was found to be injured in 63% of cases (19/30; k = 0.93). The enthesis was found to be torn in 50% of cases (15/30; k = 1), with the tear located at the tibial attachment in all instances. On the MRI exam, the ALL was found to be injured in 53% of cases (16/30; k = 0.93). The enthesis was found to be torn in 13% of cases (4/30; k = 0.76), with the tear located at the tibial attachment in all instances (k = 0.93). ALL injuries that occur with ACL tears are located at the tibial enthesis. They are often associated with bone avulsion at the enthesis and are better viewed on US. • ALL injuries often occur in combination with ACL tears. • ALL injuries can be assessed with ultrasonography and MRI. • ALL injuries associated with ACL tears are located at the tibial enthesis.
- Published
- 2017
19. Ultrasound of the coracoclavicular ligaments in the acute phase of an acromioclavicular disjonction: Comparison of radiographic, ultrasound and MRI findings
- Author
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Hélène Chiavassa Gandois, Nicolas Bonnevialle, F. Lapègue, Marie Faruch Bilfeld, Nicolas Sans, Marie Aurélie Bayol, and Centre Hospitalier Universitaire de Toulouse - CHU Toulouse (FRANCE)
- Subjects
musculoskeletal diseases ,Adult ,Male ,medicine.medical_specialty ,Radiography ,Joint Dislocations ,Coracoclavicular ligament ,Sensitivity and Specificity ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Autre ,Ultrasound ,Medicine ,Acromioclavicular joint ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Radiation treatment planning ,Neuroradiology ,Ultrasonography ,030222 orthopedics ,medicine.diagnostic_test ,business.industry ,Interventional radiology ,General Medicine ,Middle Aged ,Magnetic Resonance Imaging ,Radiographic Image Enhancement ,medicine.anatomical_structure ,Acromioclavicular Joint ,Ligaments, Articular ,Female ,Radiology ,business ,Mri findings ,Rookwood classification ,MRI - Abstract
OBJECTIVES: Acromioclavicular joint injuries are typically diagnosed by clinical and radiographic assessment with the Rockwood classification, which is crucial for treatment planning. The purpose of this study was to describe how the ultrasound findings of acromioclavicular joint injury compare with radiography and MRI findings. METHODS: Forty-seven patients with suspected unilateral acromioclavicular joint injury after acute trauma were enrolled in this prospective study. All patients underwent digital radiography, ultrasound and 3T MRI. A modified Rockwood classification was used to evaluate the coracoclavicular ligaments. The classifications of acromioclavicular joint injuries diagnosed with radiography, ultrasound and MRI were compared. MRI was used as the gold standard. RESULTS: The agreement between the ultrasound and MRI findings was very good, with a correlation coefficient of 0.83 (95 % CI: 0.72-0.90; p < 0.0001). Ultrasound detected coracoclavicular ligament injuries with a sensitivity of 88.9 %, specificity of 90.0 %, positive predictive value of 92.3 % and negative predictive value of 85.7 %. The agreement between the ultrasound and radiography findings was poor, with a correlation coefficient of 0.69 (95 % CI: 0.51-0.82; p < 0.0001). CONCLUSION: Ultrasound is an effective examination for the diagnostic work-up of lesions of the coracoclavicular ligaments in the acute phase of an acromioclavicular injury. KEY POINTS: • Ultrasound is appropriate for acute acromioclavicular trauma due to its accessibility. • Ultrasound contributes to the diagnostic work-up of acute lesions of the coracoclavicular ligaments. • Ultrasound is appropriate in patients likely to benefit from surgical treatment. • Ultrasound could be a supplement to standard radiography in acute acromioclavicular trauma.
- Published
- 2017
20. Prevalence and characteristics of intravertebral enhancement on contrast-enhanced CT scans in cancer patients
- Author
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P. Viala, Catherine Cyteval, Nicolas Molinari, Benjamin Rasselet, Raphael Tetreau, Ahmed Larbi, Patrice Taourel, Marie Faruch-Bilfeld, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), UNICANCER - Institut régional du Cancer Montpellier Val d'Aurelle (ICM), CRLCC Val d'Aurelle - Paul Lamarque, CHU Toulouse [Toulouse], Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), and CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)
- Subjects
Male ,[SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging ,[SDV]Life Sciences [q-bio] ,Contrast Media ,030218 nuclear medicine & medical imaging ,Metastasis ,0302 clinical medicine ,Spinal Stenosis ,Iodinated contrast ,Neoplasms ,Positron Emission Tomography Computed Tomography ,ComputingMilieux_MISCELLANEOUS ,Vertebra ,Aged, 80 and over ,Observer Variation ,Venous Thrombosis ,Catheter insertion ,Enhancement ,General Medicine ,Middle Aged ,Collateral circulation ,3. Good health ,Venous thrombosis ,medicine.anatomical_structure ,Female ,Radiology ,CT scan ,medicine.medical_specialty ,Collateral Circulation ,[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine ,Venous contrast ,Veins ,03 medical and health sciences ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Vein ,Aged ,Retrospective Studies ,Spinal Neoplasms ,business.industry ,medicine.disease ,Spine ,Stenosis ,Contrast medium ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,business ,Tomography, X-Ray Computed ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,030217 neurology & neurosurgery - Abstract
Study design This was a single center, retrospective observational study. Objective to investigate—in a cancer population—the prevalence and hallmarks of intravertebral enhancement (IVE) detected on contrast-enhanced CT. Summary of background data Intravertebral enhancements secondary to iodinated contrast stagnation have been described. Cancer patients have an increased risk of perivertebral venous thrombosis or stenosis secondary to several risk factors (cancer or drug induced hypercoagulability, deterioration of venous flow linked to catheter insertion, prolonged immobilization). In case of a high density lesion identified on CT, the diagnostic choice between metastasis and contrast media within bone marrow vessels may be an issue, especially as oncologic follow-up CT scans are usually performed with contrast medium injection. Methods 2572 contrast-enhanced body CT scans performed in cancer patients over 3 months in the medical imaging department of a university hospital were retrospectively reviewed. IVE was sought when paravertebral venous collateral circulation was detected and bone metastasis ruled out and classified as linear or nodular. Their locations within vertebra, their relation to the injection side and the predominant collateral venous network side were evaluated. Results Sixty-seven (2.8%) patients had a collateral paravertebral venous system and among them 21 had IVE (37%). There were 208 IVE locations involving 75 vertebrae. 199 IVE were linear-shaped (95.7%) and 9 nodular-shaped (4.3%). 80.8% were located between C6 and T4. 88.9% were localized in the vertebral body. 73.1% were located medially or ipsilateral to the injection side. Conclusion Intravertebral enhancement is found in 37% of the patients with paraspinal collateral venous circulation when a CT scan is performed for cancer. The ipsilateral or medial position of the IVE relative to the injection side and the side of the dominant perivertebral venous system, and the possibility of connecting the IVE to a paravertebral vein may be in favor of vascular opacification.
- Published
- 2016
21. Stroke Caused by a Pulmonary Vein Thrombosis Revealing a Metastatic Choriocarcinoma
- Author
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Nicolas Raposo, Louise Bonnet, Jean-François Albucher, Marie Faruch Bilfeld, François Chollet, Nathalie Blot-Souletie, Jean-Marc Olivot, and Julien Mazière
- Subjects
medicine.medical_specialty ,Subarachnoid hemorrhage ,Lung Neoplasms ,Neurological examination ,Global aphasia ,Magnetic resonance angiography ,Physiology (medical) ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Biomarkers, Tumor ,Humans ,Chorionic Gonadotropin, beta Subunit, Human ,cardiovascular diseases ,Choriocarcinoma ,Stroke ,Venous Thrombosis ,medicine.diagnostic_test ,business.industry ,Anticoagulants ,Magnetic resonance imaging ,Middle Aged ,Subarachnoid Hemorrhage ,medicine.disease ,Magnetic Resonance Imaging ,Treatment Outcome ,Pulmonary Veins ,Uterine Neoplasms ,Female ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,Echocardiography, Transesophageal ,Cerebral angiography ,Partial thromboplastin time - Abstract
A 57-year-old white woman, with history of hydatidiform mole 2 years earlier, was evaluated at our stroke center for the acute onset of intense cephalgia, vomiting, and aphasia. Recent medical history was significant for a vertebrobasilar transient ischemic attack 1 month earlier with a negative etiologic evaluation and negative vessel imaging and transesophageal echocardiography (TEE). A treatment by aspirin 160 mg was then started. On admission, neurological examination revealed a global aphasia and right homonymous hemianopsia. The National Institutes of Health Stroke Scale score was 8. She had no fever. Cardiovascular examination revealed a systolic murmur. Pulmonary auscultation was normal. A computed tomographic brain scan showed a left lobar temporal intracerebral hematoma with a subarachnoid hemorrhage in the ipsilateral sylvian fissure. Cerebral angiography and arteriography showed no vascular abnormality. Brain MRI showed a hemorrhagic infarction in the left middle cerebral artery territory and revealed several subacute infarctions in other vascular territories (Figure 1). Magnetic resonance angiography was normal. Coagulation tests involving fibrinogen, prothrombin time, activated partial thromboplastin time were normal. …
- Published
- 2015
22. Human coxal bone sexual dimorphism and multislice computed tomography: geometric morphometric analysis of 65 adults
- Author
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F. Dedouit, José Braga, Norbert Telmon, Marie Faruch Bilfeld, Nicolas Sans, Hervé Rousseau, and Daniel Rougé
- Subjects
Adult ,Male ,Ischial spine ,Biology ,White People ,Pathology and Forensic Medicine ,Imaging, Three-Dimensional ,Multidetector Computed Tomography ,Genetics ,medicine ,Humans ,Pelvic Bones ,Retrospective Studies ,Geometric morphometry ,Principal Component Analysis ,Forensic anthropology ,Discriminant Analysis ,Anatomy ,Multislice computed tomography ,Sex Determination by Skeleton ,Ischium ,Sexual dimorphism ,Ischiopubic ramus ,medicine.anatomical_structure ,Morphometric analysis ,Forensic Anthropology ,Female - Abstract
The authors studied sexually dimorphic differences in coxal shape using geometric morphometric analysis of 15 osteometric landmarks recorded by multislice computed tomography (MSCT), based on three-dimensional reconstructions of 65 Caucasian adults. Geometric morphometric analysis, principal component analysis, canonical variates analysis, and other discriminant analysis (Goodall’s F-test and Mahalanobis distance) were performed for the three separate bones of the left innominate (pubis, ilium, and ischium), the modified pubis (pubis and ischiopubic ramus), the modified ilium (ilium and ischial spine), three bone complexes (ischiopubic, iliopubic, and ilio-ischial), and the complete innominate. A cross-validation test was also performed. All areas studied were dimorphic, but results for sexual dimorphism in decreasing order were as follows: the modified pubis, followed by the ischiopubic complex, the iliopubic complex and the complete innominate, the pubis, the modified ilium, the ilio-ischial complex, the ilium, and finally the ischium. These results show the potential of this approach for future anthropological research.
- Published
- 2012
23. Value of kinematic four-dimensional imaging in the surgical management of scapholunate instabilities
- Author
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Athlani, Lionel, Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Université de Lorraine, Pedro Augusto Gondim Teixeira, Didier Mainard [Président], Isabelle Auquit-Auckbur [Rapporteur], Jean-Yves Beaulieu [Rapporteur], Gilles Dautel, Marie Faruch Bilfeld, and UL, Thèses
- Subjects
Scapholunate instability ,[SDV.MHEP.CHI] Life Sciences [q-bio]/Human health and pathology/Surgery ,Four-dimensional computed tomography ,Instabilité scapho-lunaire ,[INFO.INFO-IM] Computer Science [cs]/Medical Imaging ,Scanner dynamique quatre dimensions ,Ligamentoplasty ,[SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery ,Wrist ,Carpe ,Poignet ,Ligamentoplastie ,[INFO.INFO-IM]Computer Science [cs]/Medical Imaging ,Carpus - Abstract
Scapholunate instability is challenging to diagnose and to treat. If left untreated, it contributes to the development of wrist osteoarthritis. In the static stage, diagnosis is obvious when a careful radiographic analysis is performed, but the choice of surgical treatment is not as straightforward. In the dynamic stage, diagnosis is harder to make solely based on static imaging methods (radiographs, CT or MR arthrogram), which means exploratory arthroscopy may be required prior to surgical treatment. Despite it is an invasive procedure, arthroscopy is considered by many surgical teams, as the gold standard to explore the scapholunate joint space. Dynamic imaging, such as the four-dimensional computed tomography (4DCT), can analyze changes in the carpal joint spaces during wrist movements. Given our prospective study’s findings, 4DCT appeared as a quantitative multiparametric and reproductible relevant tool for the diagnosis and prognosis of suspected scapholunate instability, including for patients with questionable radiography findings. Abnormal kinematic parameters values seem to be indicative of significant biomechanical changes in the dissociated wrists. Moreover, 4DCT analysis demonstrated correspondence with the arthroscopic dynamic analysis of the scapholunate joint space. Several ligamentoplasty techniques have been described to treat chronic reducible scapholunate instability without chondral lesions. Their common objective is to correct radiological anomalies in order to prevent risk of osteoarthritis. These procedures have served as the basis for several clinical studies and while all the latter share similar good clinical results, the radiographic aspect varies widely, with frequently the recurrence of radiological anomalies. Thus, we described the scapholunate intercarpal ligamentoplasty (SLIC) which uses a free Palmaris Longus graft to reconstruct the scapholunate complex. At short to mid-term follow-up, we report satisfactory clinical and radiological results, and no osteoarthritis wrist case. In a cadaver study, we reported the 4DCT evaluation of that ligamentoplasty and provided additional evidence of its effectiveness in reducing scapholunate instability and restoring scapholunate joint stability. Finally, we designed a device for guiding wrist movements in order to increase the reproducibility and homogeneity of the movement during dynamic imaging acquisition., L'instabilité scapho-lunaire est difficile à diagnostiquer et à traiter. En l’absence de traitement, elle évolue vers l'arthrose du poignet. Au stade statique, le diagnostic est évident lorsqu'une analyse radiographique minutieuse est effectuée, mais le choix du traitement chirurgical n'est pas aussi simple. Au stade dynamique, le diagnostic est plus difficile à poser sur la base unique de méthodes d'imagerie statiques (radiographies, tomodensitométrie ou IRM), ce qui justifie qu'une arthroscopie exploratoire puisse être nécessaire avant le traitement chirurgical. Bien qu'il s'agisse d'une procédure invasive, l'arthroscopie est considérée par de nombreuses équipes chirurgicales comme le gold standard pour explorer l'espace articulaire scapho-lunaire. L'imagerie dynamique, telle que le scanner dynamique quatre dimensions (4DCT), peut analyser les modifications des espaces articulaires du carpe lors des mouvements du poignet. Au vu des résultats de notre étude prospective, le 4DCT est apparu comme un outil pertinent multiparamétrique quantitatif et reproductible pour le diagnostic et le pronostic de l'instabilité scapho-lunaire suspectée, y compris pour les patients présentant des résultats radiographiques douteux. Les valeurs anormales des paramètres cinématiques semblent indiquer des changements biomécaniques significatifs dans les poignets dissociés. De plus, l'analyse 4DCT a démontré une correspondance avec l'analyse dynamique arthroscopique de l'espace articulaire scapho-lunaire. Plusieurs techniques de ligamentoplastie ont été décrites pour traiter l'instabilité scapho-lunaire réductible, chronique et sans lésions chondrales. Leur objectif commun est de corriger les anomalies radiologiques afin de prévenir des risques d'arthrose. Ces procédures ont servi de base à plusieurs études cliniques, et si ces dernières partagent de bons résultats cliniques similaires, l'aspect radiographique est très variable, où la récidive des anomalies radiologiques est fréquente. Ainsi, nous avons mis au point la ligamentoplastie scapho-lunaire et inter-carpienne (SLIC) qui utilise un transplant libre de Palmaris Longus pour reconstruire le complexe scapho-lunaire. Avec un suivi à court et moyen terme, nous rapportons des résultats cliniques et radiologiques satisfaisants, et aucun cas d’arthrose. Dans une étude cadavérique, nous avons évalué en 4DCT cette ligamentoplastie et fourni des preuves supplémentaires de son efficacité dans la réduction de l'instabilité scapho-lunaire et la restauration de la stabilité articulaire de ce couple. Enfin, nous avons conçu un dispositif de guidage des mouvements du poignet, afin d'augmenter la reproductibilité et l'homogénéité du mouvement lors de l’acquisition d'imageries dynamiques.
- Published
- 2021
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