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3. The effect of air pollution on COVID‐19 severity in a sample of patients with multiple sclerosis

Author

Bergamaschi, Roberto, Ponzano, Marta, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Filippi, Massimo, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Zito, Antonio, Confalonieri, Paolo, Marfia, Girolama Alessandra, Perini, Paola, Inglese, Matilde, Trojano, Maria, Brescia Morra, Vincenzo, Pisoni, Enrico, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Sormani, Maria Pia, Gianmarco Abbadessa, Umberto Aguglia, Lia Allegorico, Rossi Beatrice Maria Allegri, Anastasia Alteno, Maria Pia Amato, Pietro Annovazzi, Carlo Antozzi, Lucia Appendino, Sebastiano Arena, Viola Baione, Roberto Balgera, Valeria Barcella, Damiano Baroncini, Caterina Barrilà, Mario A Battaglia, Alessandra Bellacosa, Gianmarco Bellucci, Roberto Bergamaschi, Valeria Bergamaschi, Daiana Bezzini, Beatrice Biolzi, Alvino Bisecco, Simona Bonavita, Giovanna Borriello, Chiara Bosa, Antonio Bosco, Francesca Bovis, Marco Bozzali, Laura Brambilla, Morra Vincenzo Brescia, Giampaolo Brichetto, Maria Buccafusca, Elisabetta Bucciantini, Sebastiano Bucello, Maria Chiara Buscarinu, Maria Paola Cabboi, Massimiliano Calabrese, Francesca Calabria, Francesca Caleri, Federico Camilli, Luisa Maria Caniatti, Roberto Cantello, Marco Capobianco, Ruggero Capra, Rocco Capuano, Luca Carmisciano, Patrizia Carta, Paola Cavalla, Maria Grazia Celani, Maria Cellerino, Raffaella Cerqua, Clara Chisari, Raffaella Clerici, Marinella Clerico, Eleonora Cocco, Gaia Cola, Giancarlo Comi, Paolo Confalonieri, Antonella Conte, Marta Zaffira Conti, Christian Cordano, Susanna Cordera, Cinzia Cordioli, Francesco Corea, Claudio Correale, Salvatore Cottone, Francesco Crescenzo, Erica Curti, Alessandro d'Ambrosio, Emanuele D'Amico, Maura Chiara Danni, Alessia d'Arma, Vincenzo Dattola, Stefano de Biase, Giovanna De Luca, Stefania Federica De Mercanti, Paolo De Mitri, Nicola De Rossi, Nicola De Stefano, Cava Marco Della, Mario di Napoli, Alessia Di Sapio, Renato Docimo, Anna Dutto, Luana Evangelista, Salvatore Fanara, Diana Ferraro, Maria Teresa Ferrò, Massimo Filippi, Cristina Fioretti, Mario Fratta, Jessica Frau, Marzia Fronza, Roberto Furlan, Alberto Gajofatto, Antonio Gallo, Paolo Gallo, Claudio Gasperini, Anna Ghazaryan, Bruno Giometto, Francesca Gobbin, Flora Govone, Franco Granella, Erica Grange, Maria Grazia Grasso, Angelica Guareschi, Clara Guaschino, Simone Guerrieri, Donata Guidetti, Pietro Iaffaldano, Antonio Ianniello, Luigi Iasevoli, Paolo Immovilli, Daniele Imperiale, Maria Teresa Infante, Matilde Inglese, Rosa Iodice, Aniello Iovino, Giovanna Konrad, Doriana Landi, Roberta Lanzillo, Caterina Lapucci, Luigi Lavorgna, Maria Rita L'Episcopo, Serena Leva, Giuseppe Liberatore, Re Marianna Lo, Marco Longoni, Leonardo Lopiano, Lorena Lorefice, Matteo Lucchini, Giacomo Lus, Davide Maimone, Maria Malentacchi, Giulia Mallucci, Simona Malucchi, Chiara Rosa Mancinelli, Luca Mancinelli, Paolo Manganotti, Giorgia Teresa Maniscalco, Vittorio Mantero, Sabrina Marangoni, Damiano Marastoni, Girolama Alessandra Marfia, Fabiana Marinelli, Alessandro Marti, Boneschi Filippo Martinelli, Zoli Federco Masserano, Francesca Matta, Laura Mendozzi, Giuseppe Meucci, Silvia Miante, Giuseppina Miele, Eva Milano, Massimiliano Mirabella, Rosanna Missione, Marcello Moccia, Lucia Moiola, Sara Montepietra, Margherita MontiBragadin, Federico Montini, Roberta Motta, Raffaele Nardone, Carolina Gabri Nicoletti, Eduardo Nobile-Orazio, Agostino Nozzolillo, Marco Onofrj, Riccardo Orlandi, Anna Palmieri, Damiano Paolicelli, Livia Pasquali, Luisa Pastò, Francesco Patti, Elisabetta Pedrazzoli, Paola Perini, Ilaria Pesci, Maria Petracca, Alfredo Petrone, Carlo Piantadosi, Anna M Pietroboni, Federica Pinardi, Marta Ponzano, Emilio Portaccio, Mattia Pozzato, Carlo Pozzilli, Luca Prosperini, Alessandra Protti, Marta Radaelli, Paolo Ragonese, Sarah Rasia, Sabrina Realmuto, Anna Repice, Eleonora Rigoni, Maria Teresa Rilla, Francesca Rinaldi, Calogero Marcello Romano, Marco Ronzoni, Marco Rovaris, Francesca Ruscica, Loredana Sabattini, Giuseppe Salemi, Marco Salvetti, Lorenzo Saraceno, Alessia Sartori, Arianna Sartori, Elvira Sbragia, Cinzia Scandellari, Giuditta Ilaria Scarano, Valentina Scarano, Irene Schiavetti, Maria Sessa, Caterina Sgarito, Grazia Sibilia, Gabriele Siciliano, Alessio Signori, Elisabetta Signoriello, Leonardo Sinisi, Francesca Sireci, Patrizia Sola, Claudio Solaro, Maria Pia Sormani, Stefano Sotgiu, Maddalena Sparaco, Maria Laura Stromillo, Silvia Strumia, Emanuela Laura Susani, Giulietta Tabiadon, Francesco Teatini, Gioacchino Tedeschi, Valentina Tomassini, Simone Tonietti, Clerici Valentina Torri, Carla Tortorella, Simona Toscano, Rocco Totaro, Maria Trojano, Maria Trotta, Gabriella Turano, Monica Ulivelli, Manzo Valentino, Giovanna Vaula, Domizia Vecchio, Marco Vercellino, Elena Pinuccia Verrengia, Marika Vianello, Eleonora Virgilio, Francesca Vitetta, Stefano Vollaro, Mauro Zaffaroni, Mauro Zampolini, Ignazio Roberto Zarbo, Antonio Zito, Luigi Zuliani, Bergamaschi, R, Ponzano, M, Schiavetti, I, Carmisciano, L, Cordioli, C, Filippi, M, Radaelli, M, Immovilli, P, Capobianco, M, De Rossi, N, Brichetto, G, Cocco, E, Scandellari, C, Cavalla, P, Pesci, I, Zito, A, Confalonieri, P, Marfia, Ga, Perini, P, Inglese, M, Trojano, M, Brescia Morra, V, Pisoni, E, Tedeschi, G, Comi, G, Battaglia, Ma, Patti, F, Salvetti, M, Sormani, Mp, Abbadessa, Gianmarco, Umberto, Aguglia, Lia, Allegorico, Rossi Beatrice Maria Allegri, Anastasia, Alteno, Maria Pia Amato, Pietro, Annovazzi, Carlo, Antozzi, Lucia, Appendino, Sebastiano, Arena, Viola, Baione, Roberto, Balgera, Valeria, Barcella, Damiano, Baroncini, Caterina, Barrilà, Mario, A Battaglia, Alessandra, Bellacosa, Gianmarco, Bellucci, Roberto, Bergamaschi, Valeria, Bergamaschi, Daiana, Bezzini, Beatrice, Biolzi, Bisecco, Alvino, Bonavita, Simona, Giovanna, Borriello, Chiara, Bosa, Bosco, Antonio, Francesca, Bovi, Marco, Bozzali, Laura, Brambilla, Morra Vincenzo Brescia, Giampaolo, Brichetto, Maria, Buccafusca, Elisabetta, Bucciantini, Sebastiano, Bucello, Maria Chiara Buscarinu, Maria Paola Cabboi, Massimiliano, Calabrese, Francesca, Calabria, Francesca, Caleri, Federico, Camilli, Luisa Maria Caniatti, Roberto, Cantello, Marco, Capobianco, Ruggero, Capra, Capuano, Rocco, Luca, Carmisciano, Patrizia, Carta, Paola, Cavalla, Maria Grazia Celani, Maria, Cellerino, Raffaella, Cerqua, Clara, Chisari, Raffaella, Clerici, Marinella, Clerico, Eleonora, Cocco, Gaia, Cola, Giancarlo, Comi, Paolo, Confalonieri, Antonella, Conte, Marta Zaffira Conti, Christian, Cordano, Susanna, Cordera, Cinzia, Cordioli, Corea, Francesco, Claudio, Correale, Salvatore, Cottone, Francesco, Crescenzo, Erica, Curti, Alessandro, D'Ambrosio, Emanuele, D'Amico, Maura Chiara Danni, Alessia, D'Arma, Vincenzo, Dattola, Stefano de Biase, Giovanna De Luca, Stefania Federica De Mercanti, Paolo De Mitri, Nicola De Rossi, Nicola De Stefano, Cava Marco Della, Mario di Napoli, Alessia Di Sapio, Docimo, Renato, Anna, Dutto, Luana, Evangelista, Salvatore, Fanara, Diana, Ferraro, Maria Teresa Ferrò, Massimo, Filippi, Cristina, Fioretti, Fratta, Mario, Jessica, Frau, Marzia, Fronza, Roberto, Furlan, Alberto, Gajofatto, Gallo, Antonio, Paolo, Gallo, Claudio, Gasperini, Anna, Ghazaryan, Bruno, Giometto, Francesca, Gobbin, Flora, Govone, Franco, Granella, Erica, Grange, Maria Grazia Grasso, Angelica, Guareschi, Clara, Guaschino, Simone, Guerrieri, Donata, Guidetti, Pietro, Iaffaldano, Antonio, Ianniello, Luigi, Iasevoli, Paolo, Immovilli, Daniele, Imperiale, Maria Teresa Infante, Matilde, Inglese, Rosa, Iodice, Aniello, Iovino, Giovanna, Konrad, Doriana, Landi, Roberta, Lanzillo, Caterina, Lapucci, Luigi, Lavorgna, Maria Rita L'Episcopo, Serena, Leva, Giuseppe, Liberatore, Re Marianna Lo, Marco, Longoni, Leonardo, Lopiano, Lorena, Lorefice, Matteo, Lucchini, Lus, Giacomo, Davide, Maimone, Maria, Malentacchi, Giulia, Mallucci, Simona, Malucchi, Chiara Rosa Mancinelli, Luca, Mancinelli, Paolo, Manganotti, Giorgia Teresa Maniscalco, Vittorio, Mantero, Sabrina, Marangoni, Damiano, Marastoni, Girolama Alessandra Marfia, Fabiana, Marinelli, Alessandro, Marti, Boneschi Filippo Martinelli, Zoli Federco Masserano, Francesca, Matta, Laura, Mendozzi, Giuseppe, Meucci, Silvia, Miante, Miele, Giuseppina, Eva, Milano, Massimiliano, Mirabella, Missione, Rosanna, Marcello, Moccia, Lucia, Moiola, Sara, Montepietra, Margherita, Montibragadin, Federico, Montini, Roberta, Motta, Raffaele, Nardone, Carolina Gabri Nicoletti, Eduardo, Nobile-Orazio, Agostino, Nozzolillo, Marco, Onofrj, Riccardo, Orlandi, Palmieri, Anna, Damiano, Paolicelli, Livia, Pasquali, Luisa, Pastò, Francesco, Patti, Elisabetta, Pedrazzoli, Paola, Perini, Ilaria, Pesci, Maria, Petracca, Alfredo, Petrone, Carlo, Piantadosi, Anna, M Pietroboni, Federica, Pinardi, Marta, Ponzano, Emilio, Portaccio, Mattia, Pozzato, Carlo, Pozzilli, Luca, Prosperini, Alessandra, Protti, Marta, Radaelli, Paolo, Ragonese, Sarah, Rasia, Sabrina, Realmuto, Anna, Repice, Eleonora, Rigoni, Maria Teresa Rilla, Francesca, Rinaldi, Calogero Marcello Romano, Marco, Ronzoni, Marco, Rovari, Francesca, Ruscica, Loredana, Sabattini, Giuseppe, Salemi, Marco, Salvetti, Lorenzo, Saraceno, Alessia, Sartori, Arianna, Sartori, Elvira, Sbragia, Cinzia, Scandellari, Giuditta Ilaria Scarano, Valentina, Scarano, Irene, Schiavetti, Maria, Sessa, Caterina, Sgarito, Grazia, Sibilia, Gabriele, Siciliano, Alessio, Signori, Signoriello, Elisabetta, Leonardo, Sinisi, Francesca, Sireci, Patrizia, Sola, Claudio, Solaro, Maria Pia Sormani, Stefano, Sotgiu, Sparaco, Maddalena, Maria Laura Stromillo, Silvia, Strumia, Emanuela Laura Susani, Giulietta, Tabiadon, Francesco, Teatini, Tedeschi, Gioacchino, Valentina, Tomassini, Simone, Tonietti, Clerici Valentina Torri, Carla, Tortorella, Simona, Toscano, Rocco, Totaro, Maria, Trojano, Trotta, Maria Consiglia, Gabriella, Turano, Monica, Ulivelli, Manzo, Valentino, Giovanna, Vaula, Domizia, Vecchio, Marco, Vercellino, Elena Pinuccia Verrengia, Marika, Vianello, Eleonora, Virgilio, Francesca, Vitetta, Stefano, Vollaro, Mauro, Zaffaroni, Mauro, Zampolini, Ignazio Roberto Zarbo, Zito, Guido Antonio, Bergamaschi, R., Ponzano, M., Schiavetti, I., Carmisciano, L., Cordioli, C., Filippi, M., Radaelli, M., Immovilli, P., Capobianco, M., De Rossi, N., Brichetto, G., Cocco, E., Scandellari, C., Cavalla, P., Pesci, I., Zito, A., Confalonieri, P., Marfia, G. A., Perini, P., Inglese, M., Trojano, M., Brescia Morra, V., Pisoni, E., Tedeschi, G., Comi, G., Battaglia, M. A., Patti, F., Salvetti, M., Sormani, M. P., Bergamaschi, Roberto, Ponzano, Marta, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Filippi, Massimo, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Zito, Antonio, Confalonieri, Paolo, Marfia, Girolama Alessandra, Perini, Paola, Inglese, Matilde, Trojano, Maria, Brescia Morra, Vincenzo, Pisoni, Enrico, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Sormani, Maria, Pia, Gianmarco, Abbadessa, Alvino, Bisecco, Simona, Bonavita, Antonio, Bosco, Rocco, Capuano, Francesco, Corea, Renato, Docimo, Mario, Fratta, Antonio, Gallo, Iodice, Rosa, Iovino, Aniello, Lanzillo, Roberta, Giacomo, Lu, Giuseppina, Miele, Rosanna, Missione, Moccia, Marcello, Anna, Palmieri, Elisabetta, Signoriello, Maddalena, Sparaco, Gioacchino, Tedeschi, Maria, Trotta, Antonio, Zito, and Luigi, Zuliani

Subjects
air pollution, coronavirus, multiple sclerosis, medicine.medical_specialty, Multivariate analysis, Coronavirus disease 2019 (COVID-19), Clinical Sciences, Air pollution, Sample (statistics), Neurodegenerative, Settore MED/26, medicine.disease_cause, Autoimmune Disease, law.invention, Sustainable Cities and Communities, Clinical Research, law, Humans, Medicine, Climate-Related Exposures and Conditions, Neurology & Neurosurgery, MuSC-19 study group, SARS-CoV-2, business.industry, Multiple sclerosis, Neurosciences, COVID-19, Retrospective cohort study, Original Articles, medicine.disease, Intensive care unit, Particulate Matter, Air Pollution, Multiple Sclerosis, Brain Disorders, coronaviru, Settore MED/26 - NEUROLOGIA, Good Health and Well Being, Neurology, multiple sclerosi, Emergency medicine, Original Article, Neurology (clinical), Ordered logit, business, Human
Abstract

Background and purpose Some studies have shown that air pollution, often assessed by thin particulate matter with diameter below 2.5 µg/m3 (PM2.5), may contribute to severe COVID‐19 courses, as well as play a role in the onset and evolution of multiple sclerosis (MS). However, the impact of air pollution on COVID‐19 has never been explored specifically amongst patients with MS (PwMS). This retrospective observational study aims to explore associations between PM2.5 and COVID‐19 severity amongst PwMS. Methods Data were retrieved from an Italian web‐based platform (MuSC‐19) which includes PwMS with COVID‐19. PM2.5 2016–2018 average concentrations were provided by the Copernicus Atmospheric Monitoring Service. Italian patients inserted in the platform from 15 January 2020 to 9 April 2021 with a COVID‐19 positive test were included. Ordered logistic regression models were used to study associations between PM2.5 and COVID‐19 severity. Results In all, 1087 patients, of whom 13% required hospitalization and 2% were admitted to an intensive care unit or died, were included. Based on the multivariate analysis, higher concentrations of PM2.5 increased the risk of worse COVID‐19 course (odds ratio 1.90; p = 0.009). Conclusions Even if several other factors explain the unfavourable course of COVID‐19 in PwMS, the role of air pollutants must be considered and further investigated., Air pollution, often assessed by particulate matter with diameter below 2.5 µg/m3, may contribute to severe COVID‐19 courses. 1087 patients were included, of whom 13% required hospitalization and 2% were admitted to an intensive care unit or died. Even if several other factors explain the unfavourable course of COVID‐19 in patients with multiple sclerosis, the role of air pollutants must be considered and further investigated.

Published
2021

4. Cuticular hydrocarbon profiles in velvet ants (Hymenoptera: Mutillidae) are highly complex and do not chemically mimic their hosts

Author

Federico Ronchetti, Thomas Schmitt, Marcello Romano, and Carlo Polidori

Subjects
Biochemistry, Ecology, Evolution, Behavior and Systematics
Abstract

Although recognition using cuticular chemistry is important for host–parasite interactions within aculeate Hymenoptera, cuticular hydrocarbon (CHC) profiles of only a few host–parasite pairs were characterized and compared. One largely neglected family in this context is the Mutillidae (velvet ants), whose species are ectoparasitoids of bees and wasps. In our study, we characterized and compared the CHC profiles of five species of Mutillidae and seven host species. The CHC profile of velvet ants differed among species and included large proportions of n-alkanes and methyl-branched alkanes. Alkenes were much less abundant in the CHC profiles of three species of velvet ants compared with their hosts, while the other two species possess a much lower abundance of methyl-branched alkanes than their hosts. Both the number of peaks and compound diversity were generally higher in velvet ants compared with their hosts. Thus, CHC profiles of parasitoids did not show signs of mimicry when compared with their hosts. In dyadic encounters between one species of velvet ant and its host bee species, the parasitoid mainly avoided interacting, while aggression by the host was rare. Our results suggest that velvet ants did not evolve chemical mimicry, perhaps in accordance with their wide host spectrum which would limit chemical specialization. However, the reduction of alkenes in social bee-attacking species and the reduction of methyl-branched alkanes in social wasp-attacking species may favour host nest invasion, since these two CHC classes are known to be important in nestmate recognition for social bees and wasps, respectively. A larger, phylogeny-corrected comparison of Mutillidae and hosts may help clarifying the evolution of the CHC profile of these parasitoids.

Published
2023

7. The three facets of the SARS-CoV-2 pandemic during the first two waves in the northern, central, and southern Italy

Author

Silvio Buscemi, Chiara Davoli, Enrico Maria Trecarichi, Helen Linda Morrone, Bruno Tassone, Carola Buscemi, Cristiana Randazzo, Anna Maria Barile, Piero Colombrita, Maurizio Soresi, Lydia Giannitrapani, Antonio Cascio, Nicola Scichilone, Carlo Cottone, Paolo Sbraccia, Valeria Guglielmi, Frida Leonetti, Alexis Elias Malavazos, Sara Basilico, Michele Carruba, Ferruccio Santini, Alessandro Antonelli, Nicola Viola, Marcello Romano, Bruno Mario Cesana, Carlo Torti, Buscemi, Silvio, Davoli, Chiara, Trecarichi, Enrico Maria, Morrone, Helen Linda, Tassone, Bruno, Buscemi, Carola, Randazzo, Cristiana, Barile, Anna Maria, Colombrita, Piero, Soresi, Maurizio, Giannitrapani, Lydia, Cascio, Antonio, Scichilone, Nicola, Cottone, Carlo, Sbraccia, Paolo, Guglielmi, Valeria, Leonetti, Frida, Malavazos, Alexis Elia, Basilico, Sara, Carruba, Michele, Santini, Ferruccio, Antonelli, Alessandro, Viola, Nicola, Romano, Marcello, Cesana, Bruno Mario, and Torti, Carlo

Subjects
COVID-19, Epidemiology, Italy, Mortality, Public health, SARS-CoV-2, Infectious Diseases, Settore MED/09 - Medicina Interna, Public Health, Environmental and Occupational Health, General Medicine, Settore MED/49 - Scienze Tecniche Dietetiche Applicate, Settore MED/13 - Endocrinologia
Abstract

Background: There is a scarcity of information in literature regarding the clinical differences and comorbidities of patients affected by Coronavirus disease 2019 (COVID-19), which could clarify the different prevalence of the outcomes (composite and only death) between several Italian regions. Objective: This study aimed to assess the heterogeneity of clinical features of patients with COVID-19 upon hospital admission and disease outcomes in the northern, central, and southern Italian regions. Methods: An observational cohort multicenter retrospective study including 1210 patients who were admitted for COVID-19 in Infectious diseases, Pulmonology, Endocrinology, Geriatrics and Internal Medicine Units in Italian cities stratified between north (263 patients); center (320 patients); and south (627 patients), during the first and second pandemic waves of SARS-CoV-2 (from February 1, 2020 to January 31, 2021). The data, obtained from clinical charts and collected in a single database, comprehended demographic characteristics, comorbidities, hospital and home pharmacological therapies, oxygen therapy, laboratory values, discharge, death and Intensive care Unit (ICU) transfer. Death or ICU transfer were defined as composite outcomes. Results: Male patients were more frequent in the northern Italian region than in the central and southern regions. Diabetes mellitus, arterial hypertension, chronic pulmonary and chronic kidney diseases were the comorbidities more frequent in the southern region; cancer, heart failure, stroke and atrial fibrillation were more frequent in the central region. The prevalence of the composite outcome was recorded more frequently in the southern region. Multivariable analysis showed a direct association between the combined event and age, ischemic cardiac disease, and chronic kidney disease, in addition to the geographical area. Conclusions: Statistically significant heterogeneity was observed in patients with COVID-19 characteristics at admission and outcomes from northern to southern Italy. The higher frequency of ICU transfer and death in the southern region may depend on the wider hospital admission of frail patients for the availability of more beds since the burden of COVID-19 on the healthcare system was less intense in southern region. In any case, predictive analysis of clinical outcomes should consider that the geographical differences that may reflect clinical differences in patient characteristics, are also related to access to health-care facilities and care modalities. Overall, the present results caution against generalizability of prognostic scores in COVID-19 patients derived from hospital cohorts in different settings.

Published
2023

9. Orbital hopping maneuvers with two Astrobee free-flyers: Ground and flight experiments

Author

Stephen, Kwok-Choon, Jennifer, Hudson, and Marcello, Romano

Subjects
orbital hopping, Astrobatics, Artificial Intelligence, Astrobee, ISS experiments, space robotics, Computer Science Applications
Abstract

Dynamic hopping maneuvers using mechanical actuation are proposed as a method of locomotion for free-flyer vehicles near or on large space structures. Such maneuvers are of interest for applications related to proximity maneuvers, observation, cargo carrying, fabrication, and sensor data collection. This study describes a set of dynamic hopping maneuver experiments performed using two Astrobees. Both vehicles were made to initially grasp onto a common free-floating handrail. From this initial condition, the active Astrobee launched itself using mechanical actuation of its robotic arm manipulator. The results are presented from the ground and flight experimental sessions completed at the Spacecraft Robotics Laboratory of the Naval Postgraduate School, the Intelligent Robotics Group facility at NASA Ames Research Center, and hopping maneuvers aboard the International Space Station. Overall, this study demonstrates that locomotion through mechanical actuation could successfully launch a free-flyer vehicle in an initial desired trajectory from another object of similar size and mass.

Published
2022

10. [Quantitative imaging in nephrology: limits and potentials of elastosonography]

Author

Antonio, Granata, Giulio, Distefano, Rosario, Maccarrone, Francesco, Pesce, Giuseppa, Costanza, Antonio, Digiacomo, Antonio, Basile, Marcello, Romano, and Vito, Cantisani

Subjects
Nephrology, Elasticity Imaging Techniques, Humans, Renal Insufficiency, Chronic, Kidney, Fibrosis
Abstract

Chronic kidney disease is characterized by increasingly amplified fibrotic processes regardless of etiology. The severity of renal fibrosis seems to correlate with an increased risk of end-stage renal disease; therefore, monitoring of renal fibrosis over time may play an important role in the follow-up of both focal and diffuse renal diseases and in evaluating the response to treatments. Renal biopsy is the only method capable of providing objective and comparable information on the extent of fibrosis, but it is not suitable for outpatient monitoring of chronic kidney disease due to its invasiveness. Elastosonography is an innovative and non-invasive ultrasound method that allows the measurement of tissue elasticity through the transmission of mechanical waves and the measurement of their propagation speed. Although some authors have demonstrated the usefulness of elastosonographic techniques for the quantification of liver fibrosis, few studies have investigated the applications of elastosonography in renal pathology. Furthermore, the depth of native kidneys, the high anisotropy of the renal tissue, and the possibility of examining only a small region of interest currently limit its spread in clinical practice. The aim of this review is to examine the physical principles of elastosonography and to review the latest evidence about the possible applications of the ARFI (acoustic radiation force impulse) technique in the study of kidney diseases.

Published
2022

12. Hirayama disease: Nosological classification and neuroimaging clues for diagnosis

Author

Salvatore Iacono, Vincenzo Di Stefano, Andrea Gagliardo, Roberto Cannella, Valentina Virzì, Sonia Pagano, Antonino Lupica, Marcello Romano, Filippo Brighina, Iacono S., Di Stefano V., Gagliardo A., Cannella R., Virzi V., Pagano S., Lupica A., Romano M., and Brighina F.

Subjects
Male, Adolescent, Neuroimaging, Spinal Muscular Atrophies of Childhood, JASSMA, Magnetic Resonance Imaging, cervical MRI, motor neuron disease, Humans, Radiology, Nuclear Medicine and imaging, Neurology (clinical), MMA, Neck, flexion MRI, Hirayama
Abstract

Hirayama disease (HD) is a rare, benign, and nonprogressive motor neuron disease (MND) affecting the upper limbs. It usually presents with weakness and amyotrophy in a single upper extremity with an insidious onset between adolescence and the third decade of life. Since its description in 1959, HD has been known under several names and eponyms in Europe and in Asian countries probably due to its heterogeneous clinical features. Thus, the unclear nosological classification makes challenging the differential diagnosis between HD and other neuromuscular conditions, such as MNDs. However, apart from the nosological difficulties and the lack of evidence-based guideline for diagnosis, the neuroimaging is the mainstay for the diagnosis of HD. Indeed, the specific findings on cervical flexion MRI usually lead to a prompt diagnosis. Here, we reviewed the nosological classifications of HD and its neuroimaging features. Also, we report a case of a 18-year-old boy who presented to our Clinic complaining of muscle weakness of the left distal upper limb without other neurological signs. The cervical MRI, in the neutral position, revealed a high T2 signal intensity in the C5-C7 cervical myelomeres as well as the loss of cervical lordosis, whereas, during neck flexion, it showed the anterior displacement of the posterior dura ad the post-gadolinium T1-weighted imaging enhancement of the posterior epidural plexus. These findings are typical for HD allowing the diagnosis as well as the differential diagnosis from other neuromuscular diseases.

Published
2022

13. An updated re-entry analysis of the Hubble Space Telescope

Author

Anthony Starks, Jennifer L. Rhatigan, Marcello Romano, Brendon Smeresky, Robert Perez-Alemany, Eryn Culton, Jonathan Lang, Zachary Lewis, Kyle Baker, Joshua Teneyck, Alexa Rizzo, Space Systems Academic Group, and Naval Postgraduate School

Subjects
Atmosphere (unit), Spacecraft, Computer science, business.industry, Rendevous and proximity operations, Spacecraft disposal, Frame (networking), Launched, Orbital debris, Aerospace Engineering, Space Shuttle, Propulsion, Aeronautics, Hubble Space Telescope, Spacecraft reentry, Trajectory, Hubble Space Telescope Spacecraft disposal Spacecraft reentry Rendevous and proximity operations Orbital debris, Satellite, Safety, Risk, Reliability and Quality, business
Abstract

First International Orbital Debris Conference, held 9-12 December, 2019 in Sugar Land, Texas. The article of record as published may be found at https://doi.org/10.1016/j.jsse.2020.07.006 The Hubble Space Telescope (HST), launched in 1990, has without question given us a better understanding of the Universe [1]. The storied spacecraft has far exceeded its design life and, in spite of four repair missions, is nearing the end of its useful lifespan. Originally designed to be returned by the Space Shuttle, the HST has no on-board propulsion system. A 2012 study estimated that without intervention, the HST will re-enter the atmosphere in approximately 2027 with a 1:240 risk of fatality [2]. This study updates that analysis with more recent de-orbit technologies and updated trajectory information. We propose a design solution to safely perform a targeted de-orbit, assuming a worst-case scenario (a non-functional, tumbling spacecraft). Multiple de-orbit options are assessed to actively capture the satellite. Results frame an approach that could be accomplished with proven technologies at reasonable cost to improve the fatality risk as required by US Government regulation [3]. Moreover, delayed action would significantly increase mission cost and complexity so we recommend a project start in the near future.

Published
2020

14. Botulinum toxin for the management of spasticity in multiple sclerosis: the Italian botulinum toxin network study

Author

Anna Castagna, Calogera Butera, Ubaldo Del Carro, M. Frontoni, S. Lori, Jessica Frau, Giancarlo Coghe, Francesco Bono, Vincenzo Brescia Morra, Antonio Carotenuto, Marcello Moccia, Pamela Latino, Stefania Lanfranchi, Morena Giovannelli, Marcello Romano, Caterina Nascimbene, Laura Rapisarda, P. Barbero, Loredana Maggi, Elisabetta Groppo, Vitalma Liotti, Roberto Eleopra, Cristina Inglese, Marcello Esposito, Maria Concetta Altavista, Emma Frasson, Maria Buccafusca, Salvatore Lo Fermo, Martina Petracca, Moccia, Marcello, Frau, Jessica, Carotenuto, Antonio, Butera, Calogera, Coghe, Giancarlo, Barbero, Pierangelo, Frontoni, Marco, Groppo, Elisabetta, Giovannelli, Morena, Del Carro, Ubaldo, Inglese, Cristina, Frasson, Emma, Castagna, Anna, Buccafusca, Maria, Latino, Pamela, Nascimbene, Caterina, Romano, Marcello, Liotti, Vitalma, Lanfranchi, Stefania, Rapisarda, Laura, Lori, Silvia, Esposito, Marcello, Maggi, Loredana, Petracca, Martina, Lo Fermo, Salvatore, Altavista, Maria Concetta, Bono, Francesco, Eleopra, Roberto, and Brescia Morra, Vincenzo

Subjects
Adult, medicine.medical_specialty, Multiple Sclerosis, Botulinum, Modified Ashworth scale, Hypophonia, Dermatology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Activities of Daily Living, Humans, Medicine, Multiple sclerosi, Symptomatic treatment, 030212 general & internal medicine, Spasticity, Botulinum Toxins, Type A, Multiple sclerosis, Adverse effect, Expanded Disability Status Scale, business.industry, General Medicine, Middle Aged, Botulinum toxin, Clinical trial, Psychiatry and Mental health, Cross-Sectional Studies, Treatment Outcome, Italy, Neuromuscular Agents, Muscle Spasticity, Concomitant, Female, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery, medicine.drug
Abstract

Botulinum toxin (BT) is an effective and safe treatment for spasticity, with limited evidence in multiple sclerosis (MS). We aim to describe the use of BT for the management of MS spasticity in the clinical practice, its combination with other anti-spastic treatments in MS and possible MS clinical correlates. This is a multicentre cross-sectional observational study including 386 MS patients, receiving BT for spasticity in 19 Italian centres (age 53.6 ± 10.9 years; female 228 (59.1%); disease duration 18.7 ± 9.2 years; baseline Expanded Disability Status Scale (EDSS) 6.5 (2.0–9.0)). BT was used for improving mobility (n = 170), functioning in activities of daily living (n = 56), pain (n = 56), posturing-hygiene (n = 63) and daily assistance (n = 41). BT formulations were AbobotulinumtoxinA (n = 138), OnabotulinumtoxinA (n = 133) and IncobotulinumtoxinA (n = 115). After conversion to unified dose units, higher BT dose was associated with higher EDSS (Coeff = 0.591; p

Published
2020

15. An Offline-Sampling SMPC Framework With Application to Autonomous Space Maneuvers

Author

Marcello Romano, Giorgio Guglieri, Elisa Capello, Fabrizio Dabbene, Hyeongjun Park, Matthias Lorenzen, Frank Allgöwer, and Martina Mammarella

Subjects
0209 industrial biotechnology, Computer science, sampling-based approach, chance constraints, 02 engineering and technology, 020901 industrial engineering & automation, 0203 mechanical engineering, Linearization, Control theory, Electrical and Electronic Engineering, Parametric statistics, 020301 aerospace & aeronautics, Stochastic Model Predictive Control, Spacecraft, business.industry, Autonomous rendezvous between spacecraft, Linear system, Probabilistic logic, Rendezvous, Sampling (statistics), real-time implementability, Model predictive control, Stochastic Model Predictive Control, Chance Constraints, Sampling-based Approach, Real-time Implementability, Rendezvous between Spacecraft, Control and Systems Engineering, stochastic model predictive control (SMPC), Rendezvous between Spacecraft, business
Abstract

In this paper, a sampling-based stochastic model predictive control (SMPC) algorithm is proposed for discrete- time linear systems subject to both parametric uncertainties and additive disturbances. One of the main drivers for the development of the proposed control strategy is the need for reliable and robust guidance and control strategies for automated rendezvous and proximity operations between spacecraft. To this end, the proposed control algorithm is validated on a floating spacecraft experimental testbed, proving that this solution is effectively implementable in real time. Parametric uncertainties due to the mass variations during operations, linearization errors, and disturbances due to external space environment are simulta- neously considered. The approach enables to suitably tighten the constraints to guarantee robust recursive feasibility when bounds on the uncertain variables are provided. Moreover, the offline sampling approach in the control design phase shifts all the intensive computations to the offline phase, thus greatly reducing the online computational cost, which usually constitutes the main limitation for the adoption of SMPC schemes, especially for low- cost on-board hardware. Numerical simulations and experiments show that the approach provides probabilistic guarantees on the success of the mission, even in rather uncertain and noisy situations, while improving the spacecraft performance in terms of fuel consumption.

Published
2020

16. Diagnostic and therapeutic recommendations in adult dystonia: a joint document by the Italian Society of Neurology, the Italian Academy for the Study of Parkinson’s Disease and Movement Disorders, and the Italian Network on Botulinum Toxin

Author

Marcello Romano, Sergio Bagnato, Maria Concetta Altavista, Laura Avanzino, Daniele Belvisi, Matteo Bologna, Francesco Bono, Miryam Carecchio, Anna Castagna, Roberto Ceravolo, Antonella Conte, Giuseppe Cosentino, Roberto Eleopra, Tommaso Ercoli, Marcello Esposito, Giovanni Fabbrini, Gina Ferrazzano, Stefania Lalli, Marcello Maria Mascia, Maurizio Osio, Roberta Pellicciari, Simona Petrucci, Enza Maria Valente, Francesca Valentino, Mario Zappia, Maurizio Zibetti, Paolo Girlanda, Michele Tinazzi, Giovanni Defazio, and Alfredo Berardelli

Subjects
Adult, Botulinum Toxins, Blepharospasm, Rehabilitation, Cervical dystonia, Parkinson Disease, Dermatology, General Medicine, Upper limb dystonia, Psychiatry and Mental health, Dystonia, Neurology, Dystonic Disorders, Botulinum toxin, Humans, Neurology (clinical)
Abstract

The diagnostic framework and the therapeutic management of patients with adult dystonia can represent a challenge for clinical neurologists. The objective of the present paper is to delineate diagnostic and therapeutic recommendations for dystonia provided by a panel of Italian experts afferent to the Italian Society of Neurology, the Italian Academy for the Study of Parkinson's Disease and Movement Disorders, and the Italian Network on Botulinum Toxin. We first discuss the clinical approach and the instrumental assessment useful for diagnostic purpose. Then, we analyze the pharmacological, surgical, and rehabilitative therapeutic options for adult dystonia. Finally, we propose a hospital-territory network model for adult dystonia management.

Published
2022

17. Western Region environmental management study [microform] : 'water (environmental) quality is a function of the social, industrial and agricultural uses within a region'

Author

Serini, Marcello Romano.

Subjects
ComputingMilieux_COMPUTERSANDEDUCATION, ComputerApplications_COMPUTERSINOTHERSYSTEMS, Uncategorized
Abstract

This thesis was scanned from the print manuscript for digital preservation and is copyright the author. Researchers can access this thesis by asking their local university, institution or public library to make a request on their behalf. Monash staff and postgraduate students can use the link in the References field.

Published
2022
Full Text
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18. The impact of obesity and dyslipidemia on Remdesivir effectiveness in hospitalized patients with SARS-CoV-2-related pneumonia: An observational study

Author

Andrea Tumminia, Raffaella Romano, Giuseppe Brugaletta, Roberto Scicali, Giuseppina Biondi, Rosario Oliveri, Marcello Romano, and Paola Magnano San Lio

Subjects
Alanine, Nutrition and Dietetics, SARS-CoV-2, Endocrinology, Diabetes and Metabolism, Remdesivir, Medicine (miscellaneous), COVID-19, Antiviral Agents, Adenosine Monophosphate, COVID-19 Drug Treatment, Dyslipidemia, Humans, Obesity, Cardiology and Cardiovascular Medicine, Dyslipidemias
Abstract

Remdesivir (GS-5734), an inhibitor of the viral RNA-dependent, RNA polymerase was early identified as a promising therapeutic candidate against COVID-19. Our aim was to evaluate the impact of several metabolic parameters on Remdesivir effectiveness among hospitalized COVID-19 patients.We conducted an observational study on patients with SARS-CoV-2-related pneumonia admitted between May 2020 and September 2021 to the COVID-19 Units of Internal Medicine, Pneumology and Intensive Care of Garibaldi Hospital, Catania, Italy, and treated with Remdesivir. The "Ordinal Scale For Clinical Improvement" was used to assess patients' clinical improvement within 28 days of hospitalization. Short-term mortality rate was also evaluated. A total of 142 patients with SARS-CoV-2-related pneumonia were studied. The prevalence of obesity (20.7% vs. 41.9%, p = 0.03), the average BMI (27.1 ± 4.4 vs. 31.1 ± 6.1, p 0.01) and the mean LDL-C levels (78 ± 19 mg/dl vs. 103 ± 18 mg/dl, p = 0.03) were significantly lower in early-improved (EI) compared to not-improved (NI) individuals. Obesity was negatively associated to clinical improvement after Remdesivir (OR 0.48, 95%CI 0.17-0.97, p = 0.04). Both obesity (OR 2.82, 95% CI 1.05-7.71, p = 0.04) and dyslipidemia (OR 2.78, 95%CI 1.17-7.16, p = 0.03) were significantly related to patients' mortality. Dyslipidemic subjects experienced a slower clinical improvement than non-dyslipidemic ones (Long-Rank p = 0.04).Our study showed that unfavorable metabolic conditions such as obesity and dyslipidemia could predict a worse clinical response to Remdesivir as well as the mortality in hospitalized COVID-19 patients. Further prospective and larger-scale studies are needed to confirm these preliminary findings.

Published
2022

19. SARS-CoV-2 serology after COVID-19 in multiple sclerosis: An international cohort study

Author

Maria Pia Sormani, Irene Schiavetti, Doriana Landi, Luca Carmisciano, Nicola De Rossi, Cinzia Cordioli, Lucia Moiola, Marta Radaelli, Paolo Immovilli, Marco Capobianco, Vincenzo Brescia Morra, Maria Trojano, Gioacchino Tedeschi, Giancarlo Comi, Mario Alberto Battaglia, Francesco Patti, Yara Dadalti Fragoso, Sedat Sen, Aksel Siva, Roberto Furlan, Marco Salvetti, Gianmarco Abbadessa, Umberto Aguglia, Lia Allegorico, Rossi Beatrice Maria Allegri, Maria Pia Amato, Pietro Annovazzi, Carlo Antozzi, Lucia Appendino, Sebastiano Arena, Viola Baione, Roberto Balgera, Valeria Barcella, Damiano Baroncini, Caterina Barrilà, Mario A. Battaglia, Alessandra Bellacosa, Gianmarco Bellucci, Roberto Bergamaschi, Valeria Bergamaschi, Daiana Bezzini, Beatrice Biolzi, Alvino Bisecco, Simona Bonavita, Giovanna Borriello, Chiara Bosa, Antonio Bosco, Francesca Bovis, Marco Bozzali, Laura Brambilla, Morra Vincenzo Brescia, Giampaolo Brichetto, Maria Buccafusca, Elisabetta Bucciantini, Sebastiano Bucello, Maria Chiara Buscarinu, Maria Paola Cabboi, Massimiliano Calabrese, Francesca Calabria, Francesca Caleri, Federico Camilli, Luisa Maria Caniatti, Roberto Cantello, Ruggero Capra, Rocco Capuano, Patrizia Carta, Paola Cavalla, Maria Grazia Celani, Maria Cellerino, Raffaella Cerqua, Clara Chisari, Raffaella Clerici, Marinella Clerico, Eleonora Cocco, Gaia Cola, Paolo Confalonieri, Antonella Conte, Marta Zaffira Conti, Christian Cordano, Susanna Cordera, Francesco Corea, Claudio Correale, Salvatore Cottone, Francesco Crescenzo, Erica Curti, Alessandro d’Ambrosio, Emanuele D’Amico, Maura Chiara Danni, Alessia d’Arma, Vincenzo Dattola, Stefano de Biase, Giovanna De Luca, Stefania Federica De Mercanti, Paolo De Mitri, Nicola De Stefano, Marco Della Cava, Mario di Napoli, Alessia Di Sapio, Renato Docimo, Anna Dutto, Luana Evangelista, Salvatore Fanara, Diana Ferraro, Maria Teresa Ferrò, Massimo Filippi, Cristina Fioretti, Mario Fratta, Jessica Frau, Marzia Fronza, Alberto Gajofatto, Antonio Gallo, Paolo Gallo, Claudio Gasperini, Anna Ghazaryan, Bruno Giometto, Francesca Gobbin, Flora Govone, Franco Granella, Erica Grange, Maria Grazia Grasso, Angelica Guareschi, Clara Guaschino, Simone Guerrieri, Donata Guidetti, Pietro Iaffaldano, Antonio Ianniello, Luigi Iasevoli, Daniele Imperiale, Maria Teresa Infante, Matilde Inglese, Rosa Iodice, Aniello Iovino, Giovanna Konrad, Roberta Lanzillo, Caterina Lapucci, Luigi Lavorgna, Rita L’Episcopo Maria, Serena Leva, Giuseppe Liberatore, Marianna Lo Re, Marco Longoni, Leonardo Lopiano, Lorena Lorefice, Matteo Lucchini, Giacomo Lus, Davide Maimone, Maria Malentacchi, Giulia Mallucci, Simona Malucchi, Chiara Rosa Mancinelli, Luca Mancinelli, Paolo Manganotti, Teresa Giorgia Maniscalco, Vittorio Mantero, Sabrina Marangoni, Damiano Marastoni, Alessandra Girolama Marfia, Fabiana Marinelli, Alessandro Marti, Filippo Martinelli Boneschi, Federco Masserano Zoli, Francesca Matta, Laura Mendozzi, Giuseppe Meucci, Silvia Miante, Giuseppina Miele, Eva Milano, Massimiliano Mirabella, Rosanna Missione, Marcello Moccia, Sara Montepietra, Margherita Monti Bragadin, Federico Montini, Roberta Motta, Raffaele Nardone, Carolina Gabri Nicoletti, Eduardo Nobile-Orazio, Agostino Nozzolillo, Marco Onofrj, Riccardo Orlandi, Anna Palmieri, Damiano Paolicelli, Livia Pasquali, Luisa Pastò, Elisabetta Pedrazzoli, Paola Perini, Ilaria Pesci, Maria Petracca, Alfredo Petrone, Carlo Piantadosi, Anna M. Pietroboni, Federica Pinardi, Marta Ponzano, Emilio Portaccio, Mattia Pozzato, Carlo Pozzilli, Luca Prosperini, Alessandra Protti, Paolo Ragonese, Sarah Rasia, Sabrina Realmuto, Anna Repice, Eleonora Rigoni, Maria Teresa Rilla, Francesca Rinaldi, Calogero Marcello Romano, Marco Ronzoni, Marco Rovaris, Francesca Ruscica, Loredana Sabattini, Giuseppe Salemi, Lorenzo Saraceno, Alessia Sartori, Arianna Sartori, Elvira Sbragia, Cinzia Scandellari, Ilaria Scarano Giuditta, Valentina Scarano, Valentina Schillaci, Maria Sessa, Caterina Sgarito, Grazia Sibilia, Gabriele Siciliano, Alessio Signori, Elisabetta Signoriello, Leonardo Sinisi, Francesca Sireci, Patrizia Sola, Claudio Solaro, Stefano Sotgiu, Maddalena Sparaco, Maria Laura Stromillo, Silvia Strumia, Laura Emanuela Susani, Giulietta Tabiadon, Francesco Teatini, Valentina Tomassini, Simone Tonietti, Clerici Valentina Torri, Carla Tortorella, Simona Toscano, Rocco Totaro, Maria Trotta, Gabriella Turano, Monica Ulivelli, Manzo Valentino, Giovanna Vaula, Domizia Vecchio, Marco Vercellino, Elena Pinuccia Verrengia, Marika Vianello, Eleonora Virgilio, Francesca Vitetta, Stefano Vollaro, Mauro Zaffaroni, Mauro Zampolini, Ignazio Roberto Zarbo, Antonio Zito, Luigi Zuliani, Sormani, M. P., Schiavetti, I., Landi, D., Carmisciano, L., De Rossi, N., Cordioli, C., Moiola, L., Radaelli, M., Immovilli, P., Capobianco, M., Brescia Morra, V., Trojano, M., Tedeschi, G., Comi, G., Battaglia, M. A., Patti, F., Fragoso, Y. D., Sen, S., Siva, A., Furlan, R., Salvetti, M., Bisecco, Alvino, Pia Sormani, Maria, Schiavetti, Irene, Landi, Doriana, Carmisciano, Luca, De Rossi, Nicola, Cordioli, Cinzia, Moiola, Lucia, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, Brescia Morra, Vincenzo, Trojano, Maria, Tedeschi, Gioacchino, Comi, Giancarlo, Alberto Battaglia, Mario, Patti, Francesco, Dadalti Fragoso, Yara, Sen, Sedat, Siva, Aksel, Furlan, Roberto, Salvetti, Marco, Study Group Gianmarco Abbadessa, MuSC-19, Aguglia, Umberto, Allegorico, Lia, Beatrice Maria Allegri, Rossi, Pia Amato, Maria, Annovazzi, Pietro, Antozzi, Carlo, Appendino, Lucia, Arena, Sebastiano, Baione, Viola, Balgera, Roberto, Barcella, Valeria, Baroncini, Damiano, Barrilà, Caterina, A Battaglia, Mario, Bellacosa, Alessandra, Bellucci, Gianmarco, Bergamaschi, Roberto, Bergamaschi, Valeria, Bezzini, Daiana, Biolzi, Beatrice, Bonavita, Simona, Borriello, Giovanna, Bosa, Chiara, Bosco, Antonio, Bovis, Francesca, Bozzali, Marco, Brambilla, Laura, Vincenzo Brescia, Morra, Brichetto, Giampaolo, Buccafusca, Maria, Bucciantini, Elisabetta, Bucello, Sebastiano, Chiara Buscarinu, Maria, Paola Cabboi, Maria, Calabrese, Massimiliano, Calabria, Francesca, Caleri, Francesca, Camilli, Federico, Maria Caniatti, Luisa, Cantello, Roberto, Capra, Ruggero, Capuano, Rocco, Carta, Patrizia, Cavalla, Paola, Grazia Celani, Maria, Cellerino, Maria, Cerqua, Raffaella, Chisari, Clara, Clerici, Raffaella, Clerico, Marinella, Cocco, Eleonora, Cola, Gaia, Confalonieri, Paolo, Conte, Antonella, Zaffira Conti, Marta, Cordano, Christian, Cordera, Susanna, Corea, Francesco, Correale, Claudio, Cottone, Salvatore, Crescenzo, Francesco, Curti, Erica, D'Ambrosio, Alessandro, D'Amico, Emanuele, Chiara Danni, Maura, D'Arma, Alessia, Dattola, Vincenzo, de Biase, Stefano, De Luca, Giovanna, Federica De Mercanti, Stefania, De Mitri, Paolo, De Stefano, Nicola, Della Cava, Marco, di Napoli, Mario, Di Sapio, Alessia, Docimo, Renato, Dutto, Anna, Evangelista, Luana, Fanara, Salvatore, Ferraro, Diana, Teresa Ferrò, Maria, Filippi, Massimo, Fioretti, Cristina, Fratta, Mario, Frau, Jessica, Fronza, Marzia, Gajofatto, Alberto, Gallo, Antonio, Gallo, Paolo, Gasperini, Claudio, Ghazaryan, Anna, Giometto, Bruno, Gobbin, Francesca, Govone, Flora, Granella, Franco, Grange, Erica, Grazia Grasso, Maria, Guareschi, Angelica, Guaschino, Clara, Guerrieri, Simone, Guidetti, Donata, Iaffaldano, Pietro, Ianniello, Antonio, Iasevoli, Luigi, Imperiale, Daniele, Teresa Infante, Maria, Inglese, Matilde, Iodice, Rosa, Iovino, Aniello, Konrad, Giovanna, Lanzillo, Roberta, Lapucci, Caterina, Lavorgna, Luigi, L'Episcopo Maria, Rita, Leva, Serena, Liberatore, Giuseppe, Lo Re, Marianna, Longoni, Marco, Lopiano, Leonardo, Lorefice, Lorena, Lucchini, Matteo, Lus, Giacomo, Maimone, Davide, Malentacchi, Maria, Mallucci, Giulia, Malucchi, Simona, Rosa Mancinelli, Chiara, Mancinelli, Luca, Manganotti, Paolo, Giorgia Maniscalco, Teresa, Mantero, Vittorio, Marangoni, Sabrina, Marastoni, Damiano, Girolama Marfia, Alessandra, Marinelli, Fabiana, Marti, Alessandro, Martinelli Boneschi, Filippo, Masserano Zoli, Federco, Matta, Francesca, Mendozzi, Laura, Meucci, Giuseppe, Miante, Silvia, Miele, Giuseppina, Milano, Eva, Mirabella, Massimiliano, Missione, Rosanna, Moccia, Marcello, Montepietra, Sara, Monti Bragadin, Margherita, Montini, Federico, Motta, Roberta, Nardone, Raffaele, Gabri Nicoletti, Carolina, Nobile-Orazio, Eduardo, Nozzolillo, Agostino, Onofrj, Marco, Orlandi, Riccardo, Palmieri, Anna, Paolicelli, Damiano, Pasquali, Livia, Pastò, Luisa, Pedrazzoli, Elisabetta, Perini, Paola, Pesci, Ilaria, Petracca, Maria, Petrone, Alfredo, Piantadosi, Carlo, M Pietroboni, Anna, Pinardi, Federica, Ponzano, Marta, Portaccio, Emilio, Pozzato, Mattia, Pozzilli, Carlo, Prosperini, Luca, Protti, Alessandra, Ragonese, Paolo, Rasia, Sarah, Realmuto, Sabrina, Repice, Anna, Rigoni, Eleonora, Teresa Rilla, Maria, Rinaldi, Francesca, Marcello Romano, Calogero, Ronzoni, Marco, Rovaris, Marco, Ruscica, Francesca, Sabattini, Loredana, Salemi, Giuseppe, Saraceno, Lorenzo, Sartori, Alessia, Sartori, Arianna, Sbragia, Elvira, Scandellari, Cinzia, Scarano Giuditta, Ilaria, Scarano, Valentina, Schillaci, Valentina, Sessa, Maria, Sgarito, Caterina, Sibilia, Grazia, Siciliano, Gabriele, Signori, Alessio, Signoriello, Elisabetta, Sinisi, Leonardo, Sireci, Francesca, Sola, Patrizia, Solaro, Claudio, Sotgiu, Stefano, Sparaco, Maddalena, Laura Stromillo, Maria, Strumia, Silvia, Emanuela Susani, Laura, Tabiadon, Giulietta, Teatini, Francesco, Tomassini, Valentina, Tonietti, Simone, Valentina Torri, Clerici, Tortorella, Carla, Toscano, Simona, Totaro, Rocco, Trotta, Maria, Turano, Gabriella, Ulivelli, Monica, Valentino, Manzo, Vaula, Giovanna, Vecchio, Domizia, Vercellino, Marco, Pinuccia Verrengia, Elena, Vianello, Marika, Virgilio, Eleonora, Vitetta, Francesca, Vollaro, Stefano, Zaffaroni, Mauro, Zampolini, Mauro, Roberto Zarbo, Ignazio, Zito, Antonio, Zuliani, Luigi, Abbadessa, Gianmarco, Trotta, Maria Consiglia, and Zito, Guido Antonio

Subjects
0301 basic medicine, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), immunosuppressive therapie, coronavirus, Settore MED/26, medicine.disease_cause, Antibodies, Viral, immunosuppressive therapies, Antibodies, Serology, Cohort Studies, Multiple sclerosis, 03 medical and health sciences, 0302 clinical medicine, Seroepidemiologic Studies, Pandemic, Medicine, Humans, Multiple sclerosi, Viral, Coronavirus, business.industry, immunomodulatory therapie, immunomodulatory therapies, COVID-19, medicine.disease, Virology, coronaviru, Settore MED/26 - NEUROLOGIA, Sars-COV-2, 030104 developmental biology, Neurology, Neurology (clinical), business, SARS-CoV-2, Multiple Sclerosis, 030217 neurology & neurosurgery, Cohort study
Abstract

Background: The MuSC-19 project is an Italian cohort study open to international partners that collects data on multiple sclerosis (MS) patients with COVID-19. During the second wave of the pandemic, serological tests became routinely available. Objective: To evaluate the seroprevalence of anti-SARS-CoV-2 antibodies according to the use of disease-modifying therapy (DMT) in a subset of patients included in the MuSC-19 data set who had undergone a serological test. Methods: We evaluated the association between positive serological test results and time elapsed since infection onset, age, sex, Expanded Disability Status Scale score, comorbidities and DMT exposure using a multivariable logistic model. Results: Data were collected from 423 patients (345 from Italy, 61 from Turkey and 17 from Brazil) with a serological test performed during follow-up. Overall, 325 out of 423 tested patients (76.8%) had a positive serological test. At multivariate analysis, therapy with anti-CD20 was significantly associated with a reduced probability of developing antibodies after COVID-19 (odds ratio (OR) = 0.20, p = 0.002). Conclusion: Patients with MS maintain the capacity to develop humoral immune response against SARS-COV-2, although to a lesser extent when treated with anti-CD20 drugs. Overall, our results are reassuring with respect to the possibility to achieve sufficient immunization with vaccination.

Published
2021

20. COVID-19 Severity in Multiple Sclerosis: Putting Data Into Context

Author

Maria Pia Sormani, Irene Schiavetti, Luca Carmisciano, Cinzia Cordioli, Massimo Filippi, Marta Radaelli, Paolo Immovilli, Marco Capobianco, Nicola De Rossi, Giampaolo Brichetto, Eleonora Cocco, Cinzia Scandellari, Paola Cavalla, Ilaria Pesci, Antonio Zito, Paolo Confalonieri, Girolama Alessandra Marfia, Paola Perini, Matilde Inglese, Maria Trojano, Vincenzo Brescia Morra, Gioacchino Tedeschi, Giancarlo Comi, Mario Alberto Battaglia, Francesco Patti, Marco Salvetti, Gianmarco Abbadessa, Umberto Aguglia, Lia Allegorico, Beatrice Maria Allegri Rossi, Maria Pia Amato, Pietro Annovazzi, Carlo Antozzi, Lucia Appendino, Sebastiano Arena, Viola Baione, Roberto Balgera, Valeria Barcella, Damiano Baroncini, Caterina Barrilà, Alessandra Bellacosa, Gianmarco Bellucci, Roberto Bergamaschi, Valeria Bergamaschi, Daiana Bezzini, Beatrice Biolzi, Alvino Bisecco, Simona Bonavita, Giovanna Borriello, Chiara Bosa, Antonio Bosco, Francesca Bovis, Marco Bozzali, Laura Brambilla, Maria Buccafusca, Elisabetta Bucciantini, Sebastiano Bucello, Maria Chiara Buscarinu, Maria Paola Cabboi, Massimiliano Calabrese, Francesca Calabria, Francesca Caleri, Federico Camilli, Luisa Maria Caniatti, Roberto Cantello, Ruggero Capra, Rocco Capuano, Patrizia Carta, Maria Grazia Celani, Maria Cellerino, Raffaella Cerqua, Clara Chisari, Raffaella Clerici, Marinella Clerico, Gaia Cola, Antonella Conte, Marta Zaffira Conti, Christian Cordano, Susanna Cordera, Francesco Corea, Claudio Correale, Salvatore Cottone, Francesco Crescenzo, Erica Curti, Alessandro d'Ambrosio, Emanuele D'Amico, Maura Chiara Danni, Alessia d'Arma, Vincenzo Dattola, Stefano de Biase, Giovanna De Luca, Stefania Federica De Mercanti, Paolo De Mitri, Nicola De Stefano, Marco Della Cava, Mario di Napoli, Alessia Di Sapio, Renato Docimo, Anna Dutto, Luana Evangelista, Salvatore Fanara, Ferraro Diana, Maria Teresa Ferrò, Cristina Fioretti, Mario Fratta, Jessica Frau, Marzia Fronza, Roberto Furlan, Alberto Gajofatto, Antonio Gallo, Paolo Gallo, Claudio Gasperini, Anna Ghazaryan, Bruno Giometto, Francesca Gobbin, Flora Govone, Franco Granella, Erica Grange, Maria Grazia Grasso, Angelica Guareschi, Clara Guaschino, Simone Guerrieri, Donata Guidetti, Pietro Iaffaldano, Antonio Ianniello, Luigi Iasevoli, Daniele Imperiale, Maria Teresa Infante, Rosa Iodice, Aniello Iovino, Giovanna Konrad, Doriana Landi, Roberta Lanzillo, Caterina Lapucci, Luigi Lavorgna, Maria Rita L'Episcopo, Serena Leva, Giuseppe Liberatore, Marianna Lo Re, Marco Longoni, Leonardo Lopiano, Lorena Lorefice, Matteo Lucchini, Giacomo Lus, Davide Maimone, Maria Malentacchi, Giulia Mallucci, Simona Malucchi, Chiara Rosa Mancinelli, Luca Mancinelli, Paolo Manganotti, Giorgia Teresa Maniscalco, Vittorio Mantero, Sabrina Marangoni, Damiano Marastoni, Fabiana Marinelli, Alessandro Marti, Filippo Martinelli Boneschi, Federco Masserano Zoli, Francesca Matta, Laura Mendozzi, Giuseppe Meucci, Silvia Miante, Giuseppina Miele, Eva Milano, Massimiliano Mirabella, Rosanna Missione, Marcello Moccia, Lucia Moiola, Sara Montepietra, Margherita MontiBragadin, Federico Montini, Roberta Motta, Raffaele Nardone, Carolina Gabri Nicoletti, Eduardo Nobile-Orazio, Agostino Nozzolillo, Marco Onofrj, Riccardo Orlandi, Anna Palmieri, Damiano Paolicelli, Livia Pasquali, Luisa Pastò, Elisabetta Pedrazzoli, Maria Petracca, Alfredo Petrone, Carlo Piantadosi, Anna M Pietroboni, Federica Pinardi, Marta Ponzano, Emilio Portaccio, Mattia Pozzato, Carlo Pozzilli, Luca Prosperini, Alessandra Protti, Paolo Ragonese, Sarah Rasia, Sabrina Realmuto, Anna Repice, Eleonora Rigoni, Maria Teresa Rilla, Francesca Rinaldi, Calogero Marcello Romano, Marco Ronzoni, Marco Rovaris, Francesca Ruscica, Loredana Sabattini, Giuseppe Salemi, Lorenzo Saraceno, Alessia Sartori, Arianna Sartori, Elvira Sbragia, Giuditta Ilaria Scarano, Valentina Scarano, Valentina Schillaci, Maria Sessa, Caterina Sgarito, Grazia Sibilia, Gabriele Siciliano, Alessio Signori, Elisabetta Signoriello, Leonardo Sinisi, Francesca Sireci, Patrizia Sola, Claudio Solaro, Stefano Sotgiu, Maddalena Sparaco, Maria Laura Stromillo, Silvia Strumia, Emanuela Laura Susani, Giulietta Tabiadon, Francesco Teatini, Valentina Tomassini, Simone Tonietti, Clerici Valentina Torri, Carla Tortorella, Simona Toscano, Rocco Totaro, Maria Trotta, Gabriella Turano, Monica Ulivelli, Manzo Valentino, Giovanna Vaula, Domizia Vecchio, Marco Vercellino, Elena Pinuccia Verrengia, Marika Vianello, Eleonora Virgilio, Francesca Vitetta, Stefano Vollaro, Mauro Zaffaroni, Mauro Zampolini, Ignazio Roberto Zarbo, Luigi Zuliani, Pia Sormani, Maria, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Filippi, Massimo, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Zito, Guido Antonio, Confalonieri, Paolo, Alessandra Marfia, Girolama, Perini, Paola, Inglese, Matilde, Trojano, Maria, Brescia Morra, Vincenzo, Tedeschi, Gioacchino, Comi, Giancarlo, Alberto Battaglia, Mario, Patti, Francesco, Salvetti, Marco, Abbadessa, Gianmarco, Aguglia, Umberto, Allegorico, Lia, Maria Allegri Rossi, Beatrice, Pia Amato, Maria, Annovazzi, Pietro, Antozzi, Carlo, Appendino, Lucia, Arena, Sebastiano, Baione, Viola, Balgera, Roberto, Barcella, Valeria, Baroncini, Damiano, Barrilà, Caterina, Bellacosa, Alessandra, Bellucci, Gianmarco, Bergamaschi, Roberto, Bergamaschi, Valeria, Bezzini, Daiana, Biolzi, Beatrice, Bisecco, Alvino, Bonavita, Simona, Borriello, Giovanna, Bosa, Chiara, Bosco, Antonio, Bovis, Francesca, Bozzali, Marco, Brambilla, Laura, Buccafusca, Maria, Bucciantini, Elisabetta, Bucello, Sebastiano, Chiara Buscarinu, Maria, Paola Cabboi, Maria, Calabrese, Massimiliano, Calabria, Francesca, Caleri, Francesca, Camilli, Federico, Maria Caniatti, Luisa, Cantello, Roberto, Capra, Ruggero, Capuano, Rocco, Carta, Patrizia, Grazia Celani, Maria, Cellerino, Maria, Cerqua, Raffaella, Chisari, Clara, Clerici, Raffaella, Clerico, Marinella, Cola, Gaia, Conte, Antonella, Zaffira Conti, Marta, Cordano, Christian, Cordera, Susanna, Corea, Francesco, Correale, Claudio, Cottone, Salvatore, Crescenzo, Francesco, Curti, Erica, D'Ambrosio, Alessandro, D'Amico, Emanuele, Chiara Danni, Maura, D'Arma, Alessia, Dattola, Vincenzo, de Biase, Stefano, De Luca, Giovanna, Federica De Mercanti, Stefania, De Mitri, Paolo, De Stefano, Nicola, Della Cava, Marco, di Napoli, Mario, Di Sapio, Alessia, Docimo, Renato, Dutto, Anna, Evangelista, Luana, Fanara, Salvatore, Diana, Ferraro, Teresa Ferrò, Maria, Fioretti, Cristina, Fratta, Mario, Frau, Jessica, Fronza, Marzia, Furlan, Roberto, Gajofatto, Alberto, Gallo, Antonio, Gallo, Paolo, Gasperini, Claudio, Ghazaryan, Anna, Giometto, Bruno, Gobbin, Francesca, Govone, Flora, Granella, Franco, Grange, Erica, Grazia Grasso, Maria, Guareschi, Angelica, Guaschino, Clara, Guerrieri, Simone, Guidetti, Donata, Iaffaldano, Pietro, Ianniello, Antonio, Iasevoli, Luigi, Imperiale, Daniele, Teresa Infante, Maria, Iodice, Rosa, Iovino, Aniello, Konrad, Giovanna, Landi, Doriana, Lanzillo, Roberta, Lapucci, Caterina, Lavorgna, Luigi, Rita L'Episcopo, Maria, Leva, Serena, Liberatore, Giuseppe, Lo Re, Marianna, Longoni, Marco, Lopiano, Leonardo, Lorefice, Lorena, Lucchini, Matteo, Lus, Giacomo, Maimone, Davide, Malentacchi, Maria, Mallucci, Giulia, Malucchi, Simona, Rosa Mancinelli, Chiara, Mancinelli, Luca, Manganotti, Paolo, Teresa Maniscalco, Giorgia, Mantero, Vittorio, Marangoni, Sabrina, Marastoni, Damiano, Marinelli, Fabiana, Marti, Alessandro, Martinelli Boneschi, Filippo, Masserano Zoli, Federco, Matta, Francesca, Mendozzi, Laura, Meucci, Giuseppe, Miante, Silvia, Miele, Giuseppina, Milano, Eva, Mirabella, Massimiliano, Missione, Rosanna, Moccia, Marcello, Moiola, Lucia, Montepietra, Sara, Montibragadin, Margherita, Montini, Federico, Motta, Roberta, Nardone, Raffaele, Gabri Nicoletti, Carolina, Nobile-Orazio, Eduardo, Nozzolillo, Agostino, Onofrj, Marco, Orlandi, Riccardo, Palmieri, Anna, Paolicelli, Damiano, Pasquali, Livia, Pastò, Luisa, Pedrazzoli, Elisabetta, Petracca, Maria, Petrone, Alfredo, Piantadosi, Carlo, M Pietroboni, Anna, Pinardi, Federica, Ponzano, Marta, Portaccio, Emilio, Pozzato, Mattia, Pozzilli, Carlo, Prosperini, Luca, Protti, Alessandra, Ragonese, Paolo, Rasia, Sarah, Realmuto, Sabrina, Repice, Anna, Rigoni, Eleonora, Teresa Rilla, Maria, Rinaldi, Francesca, Marcello Romano, Calogero, Ronzoni, Marco, Rovaris, Marco, Ruscica, Francesca, Sabattini, Loredana, Salemi, Giuseppe, Saraceno, Lorenzo, Sartori, Alessia, Sartori, Arianna, Sbragia, Elvira, Ilaria Scarano, Giuditta, Scarano, Valentina, Schillaci, Valentina, Sessa, Maria, Sgarito, Caterina, Sibilia, Grazia, Siciliano, Gabriele, Signori, Alessio, Signoriello, Elisabetta, Sinisi, Leonardo, Sireci, Francesca, Sola, Patrizia, Solaro, Claudio, Sotgiu, Stefano, Sparaco, Maddalena, Laura Stromillo, Maria, Strumia, Silvia, Laura Susani, Emanuela, Tabiadon, Giulietta, Teatini, Francesco, Tomassini, Valentina, Tonietti, Simone, Valentina Torri, Clerici, Tortorella, Carla, Toscano, Simona, Totaro, Rocco, Trotta, Maria Consiglia, Turano, Gabriella, Ulivelli, Monica, Valentino, Manzo, Vaula, Giovanna, Vecchio, Domizia, Vercellino, Marco, Pinuccia Verrengia, Elena, Vianello, Marika, Virgilio, Eleonora, Vitetta, Francesca, Vollaro, Stefano, Zaffaroni, Mauro, Zampolini, Mauro, Roberto Zarbo, Ignazio, Zuliani, Luigi, Sormani, M. P., Schiavetti, I., Carmisciano, L., Cordioli, C., Filippi, M., Radaelli, M., Immovilli, P., Capobianco, M., De Rossi, N., Brichetto, G., Cocco, E., Scandellari, C., Cavalla, P., Pesci, I., Zito, A., Confalonieri, P., Marfia, G. A., Perini, P., Inglese, M., Trojano, M., Brescia Morra, V., Tedeschi, G., Comi, G., Battaglia, M. A., Patti, F., Salvetti, M., Zito, Antonio, BRESCIA MORRA, Vincenzo, Trotta, Maria, Sormani, Maria Pia, Marfia, Girolama Alessandra, and Battaglia, Mario Alberto

Subjects
Adult, Male, medicine.medical_specialty, Multiple Sclerosis, Coronavirus disease 2019 (COVID-19), Population, Intensive Care Unit, COVID-19, Cohort Studies, Comorbidity, Female, Hospitalization, Humans, Intensive Care Units, Italy, Middle Aged, Retrospective Studies, Risk Factors, Severity of Illness Index, Context (language use), Settore MED/26, Lower risk, Retrospective Studie, Internal medicine, Multiple Sclerosi, Medicine, In patient, National level, education, education.field_of_study, Expanded Disability Status Scale, business.industry, Risk Factor, Ethics committee, medicine.disease, Icu admission, Settore MED/26 - NEUROLOGIA, Neurology, Relative risk, Family medicine, Cohort, Honorarium, Observational study, Neurology (clinical), Cohort Studie, business, Human
Abstract

Background: It is unclear how multiple sclerosis (MS) affects the severity of Covid-19. Methods: Hospitalization, Intensive Care Unit (ICU) admission and death after Covid-19 diagnosis of 1362 MS patients were compared to the age and sex-matched Italian population in a retrospective observational case-cohort study with population-based control. The observed vs the expected events were compared in the whole MS cohort and in different subgroups (higher-risk: EDSS>3 or at least one comorbidity, lower-risk: EDSS

Published
2021

21. Neuropathic Pain and Ultrasonography: A Multiperspective Literature Evaluation

Author

Stefano Masiero, Luca Padua, D. Coraci, Michele Vecchio, Silvia Giovannini, Augusto Fusco, Marcello Romano, Valter Santilli, Serena V. Capobianco, Claudia Loreti, and Salvatore Calvaruso

Subjects
medicine.medical_specialty, Medicine (General), diagnosis, Clinical Biochemistry, Review, Disease, rehabilitation, Piriformis syndrome, R5-920, medicine, Medical physics, pain, Neuropathic Pain, Ultrasonography, treatment, business.industry, ultrasound, Scientific production, Lexical analysis, Settore MED/09 - MEDICINA INTERNA, Diagnosis, Graph-theory, Pain, Rehabilitation, Treatment, Ultrasound, Subject (documents), medicine.disease, Literature evaluation, Settore MED/26 - NEUROLOGIA, Neuropathic pain, graph-theory, business, Settore MED/34 - MEDICINA FISICA E RIABILITATIVA
Abstract

Among the tools useful for the management of neuropathic pain, ultrasound presents several advantages, shown by the literature. We assessed the scientific production about neuropathic pain and ultrasound from different points of view: general topics, journal categories, geographical origin and lexical analysis. We searched papers on PubMed using the Medical Subject Headings “neuropathic pain” AND “ultrasound”. We collected data about the journals where the papers were published, the country of the affiliation of the first author. For the lexical analysis, we evaluated the presence of selected words in the papers, and we built a graph representing the connections among words and papers. The papers were focused on the use of ultrasound as a diagnostic tool and guide for the therapy, assessing its application in different diseases such as Morton’s neuroma and piriformis syndrome. The most represented journal category was anesthesia while the most common country the United States of America. The lexical analysis confirmed the importance of ultrasound for diagnosis of specific disease and treatment of pain. The described approaches provide a multiperspective evaluation of the literature and may support the interpretation of the information contained by the papers.

Published
2021

22. List of scientific publications by Bruno Massa

Author

Salvatore Surdo, Tommaso La Mantia, Marcello Romano, Attilio Carapezza, Lo Cascio,P, Troia,A, La Mantia,T, Badalamenti,E, Carapezza,A, and Salvatore Surdo, Tommaso La Mantia, Marcello Romano, Attilio Carapezza

Subjects
The scientific articles, abstracts and books, Bruno Massa
Abstract

The scientific articles (including abstracts and books) published by Bruno Massa are listed according to years. The numerous reviews Bruno has written in recent years, greatly contributing to the dissemination of scientific knowledge, are excluded.

Published
2020

23. Real-Time Autonomous Spacecraft Proximity Maneuvers and Docking Using an Adaptive Artificial Potential Field Approach

Author

Marcello Romano, Richard Zappulla, Hyeongjun Park, and Josep Virgili-Llop

Subjects
020301 aerospace & aeronautics, 0209 industrial biotechnology, Spacecraft, Computer science, business.industry, Rendezvous, ComputerApplications_COMPUTERSINOTHERSYSTEMS, Control engineering, APF, 02 engineering and technology, Trajectory optimization, Adaptive artificial potential function (AAPF), real-time control, spacecraft guidance and control, Vehicle dynamics, 020901 industrial engineering & automation, 0203 mechanical engineering, Control and Systems Engineering, Adaptive system, Path (graph theory), Trajectory, State (computer science), Electrical and Electronic Engineering, business
Abstract

In an effort to pursue more advanced missions in space, improved on-board trajectory optimization and path (re)planning capabilities are necessary. Over the past decades, numerous missions have pushed the state of the art in autonomous rendezvous and proximity operations (RPOs). Regardless of the mission, any RPO guidance algorithm must be able to react to a dynamic environment while generating a fuel-efficient trajectory. An adaptive artificial potential function (AAPF) guidance exhibiting these properties has been experimentally evaluated on a spacecraft air-bearing test bed and its performance compared to traditional APF and other real-time guidance methods.

Published
2019

24. Equilibrium-Based Force and Torque Control for an Aerial Manipulator to Interact with a Vertical Surface

Author

Bruno Tavora, Marcello Romano, Hyeongjun Park, and Xiaoping Yun

Subjects
Surface (mathematics), 0209 industrial biotechnology, Interaction, Computer science, Aerial manipulation, Force and torque control, Multicopter, Robotic arm, General Mathematics, 02 engineering and technology, 030204 cardiovascular system & hematology, Computer Science Applications, 03 medical and health sciences, Nonlinear system, 020901 industrial engineering & automation, 0302 clinical medicine, Control and Systems Engineering, Control theory, Torque controller, Torque, Manipulator, Software
Abstract

SUMMARYIn this paper, a force and torque controller for aerial manipulation is developed using an unmanned aerial vehicle equipped with a robotic arm to interact near or on a vertical surface such as a wall. Control of aerial manipulators interacting with the environment is a challenging task due to dynamic interactions between aerial vehicles, robotic arms, and environment. To achieve this, modeling of aerial manipulators is first investigated and presented considering interaction with the environment. Nonlinear models of generic aerial manipulators, as well as of a prototype aerial manipulator composed of a hexacopter with a three-joint robotic arm, are established. An equilibrium-based force and torque controller is developed to conduct tasks that require the aerial manipulator to exert forces and torques on a wall. Simulations and experiments validate the performance of the controller that successfully applies desired forces and torques to an object fixed on a wall while flying near the wall.

Published
2019

25. Ultrasound Imaging of Abdominal Wall Endometriosis: A Pictorial Review

Author

Giuseppe Balconi, Marcello Romano, Marco Scioscia, Giulio Cocco, Vincenzo Ricci, Andrea Boccatonda, Andrea Delli Pizzi, Marco Tana, Matteo Candeloro, and Cosima Schiavone

Subjects
medicine.medical_specialty, Clinical Biochemistry, Endometriosis, Physical examination, abdominal wall endometriosis, Review, 030218 nuclear medicine & medical imaging, Abdominal wall, 03 medical and health sciences, 0302 clinical medicine, Peritoneum, Stroma, medicine, Medical history, lcsh:R5-920, 030219 obstetrics & reproductive medicine, cesarean scar, medicine.diagnostic_test, business.industry, ultrasound, Ultrasound, medicine.disease, medicine.anatomical_structure, Ultrasound imaging, Radiology, business, gynecological surgical scar, lcsh:Medicine (General)
Abstract

Endometriosis is a debilitating disease characterized by endometrial glands and stroma outside the endometrial cavity. Abdominal wall endometriosis (AWE) indicates the presence of ectopic endometrium between the peritoneum and the skin, including subcutaneous adipose tissue and muscle layers, often following obstetric and gynecological surgical procedures. AWE is a not infrequent gynecological surgical complication, due to the increasing number of cesarean sections worldwide. In this pictorial review, we discuss the importance of medical history and physical examination, including the main ultrasound features in the diagnosis of AWE.

Published
2021

26. Neuroimaging in idiopathic adult-onset focal dystonia

Author

Fabbrini, Giovanni, Conte, Antonella, Ferrazzano, Gina, Esposito, Marcello, Albanese, Alberto, Pellicciari, Roberta, Di Biasio, Francesca, Bono, Francesco, Eleopra, Roberto, Ercoli, Tommaso, Altavista, Maria Concetta, Berardelli, Alfredo, Defazio, Giovanni, Italian Dystonia Registry participants: Stefania Lalli, Roberto, Erro, Paolo, Barone, Sara, Scannapieco, Roberta, Marchese, Giulio, Demonte, Domenico, Santangelo, Laura, Avanzino, Grazia, Devigili, Valentina, Durastanti, Marinella, Turla, Sonia, Mazzucchi, Martina, Petracca, Anna Rita Bentivoglio, Maurizio, Zibetti, Bertolasi, Laura, Maria Sofia Cotelli, Roberto, Ceravolo, Cesa, Scaglione, Giovanni, Cossu, Valentina, Oppo, Pierangelo, Barbero, Paolo, Girlanda, Francesca, Morgante, Mario Coletti Moja, Salvatore, Misceo, Giulia Di Lazzaro, Antonio, Pisani, Giovanna, Squintani, Tinazzi, Michele, Nicola, Modugno, Luca, Maderna, Brigida, Minafra, Luca, Magistrelli, Marcello, Romano, Marco, Aguggia, Nicola, Tambasco, Anna, Castagna, and Daniela, Cassano

Subjects
Adult, congenital, hereditary, and neonatal diseases and abnormalities, Pediatrics, medicine.medical_specialty, Neurology, Blepharospasm, Cervical dystonia, Laryngeal dystonia, Arm dystonia, Magnetic resonance imaging, Neuroimaging, Dermatology, Spasmodic dysphonia, 03 medical and health sciences, 0302 clinical medicine, otorhinolaryngologic diseases, medicine, Humans, 030212 general & internal medicine, Torticollis, Neuroradiology, Dystonia, business.industry, General Medicine, Italy, Dystonic Disorders, Focal dystonia, medicine.disease, nervous system diseases, Psychiatry and Mental health, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

We aimed to study the attitude of Italian neurologists in the use of conventional MRI in patients with idiopathic adult-onset focal dystonia. Patients were included in the Italian Dystonia Registry by experts working in different Italian centers. MRI was available for 1045 of the 1471 (71%) patients included in the analysis. Using logistic regression analysis, we found that MRI was more likely to be performed in patients with cervical dystonia, spasmodic dysphonia, or non-task-specific upper limb dystonia, whereas it was less likely to be performed in patients with blepharospasm or task-specific upper limb dystonia. We did not find differences in the number of MRIs performed between neurological centers in Northern, Central, and Southern Italy. We conclude that although the diagnosis of idiopathic adult-onset dystonia is mainly based on clinical grounds, many movement disorder experts rely on MRI to confirm a diagnosis of idiopathic dystonia. We suggest that neuroimaging should be used in patients with adult-onset focal dystonia to rule out secondary forms.

Published
2021

28. Direct and indirect effects of sars-cov-2 pandemic in subjects with familial hypercholesterolemia: A single lipid-center real-world evaluation

Author

Francesco Purrello, Agnese Filippello, Antonino Di Pino, Alessandra Scamporrino, Stefania Di Mauro, Salvatore Piro, Roberto Scicali, Viviana Ferrara, and Marcello Romano

Subjects
Healthcare system, 2019-20 coronavirus outbreak, medicine.medical_specialty, Vascular imaging, medicine.diagnostic_test, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Familial hypercholesterolemia, Lipid-lowering therapy, Retrospective cohort study, General Medicine, medicine.disease, Cardiovascular risk, Article, body regions, Telephone survey, Internal medicine, medicine, Medicine, SARS-CoV-2 pandemic, Lipid profile, business
Abstract

We evaluated the impact of direct and indirect effects of SARS-CoV-2 infection in subjects with familial hypercholesterolemia (FH). In this observational, retrospective study, 260 FH subjects participated in a telephone survey concerning lipid profile values, lipidologist and cardiologist consultations and vascular imaging evaluation during the 12 months before and after the Italian lockdown. The direct effect was defined as SARS-CoV-2 infection, the indirect effect was defined as the difference in one of the parameters evaluated by the telephone survey before and after lockdown. Among FH subjects, the percentage of the lipid profile evaluation was lower after lockdown than before lockdown (56.5% vs. 100.0%, p &lt, 0.01), HDL-C was significantly reduced (47.78 ± 10.12 vs. 53.2 ± 10.38 mg/dL, p &lt, 0.05) and a significant increase in non-HDL-C was found (117.24 ± 18.83 vs. 133.09 ± 19.01 mg/dL, p &lt, 0.05). The proportions of lipidologist and/or cardiologist consultations and/or vascular imaging were lower after lockdown than before lockdown (for lipidologist consultation 33.5% vs. 100.0%, p &lt, 0.001, for cardiologist consultation 22.3% vs. 60.8%, p &lt, 0.01, for vascular imaging 19.6% vs. 100.0%, p &lt, 0.001), the main cause of missed lipid profile analysis and/or healthcare consultation was the fear of SARS-CoV-2 contagion. The percentage of FH subjects affected by SARS-CoV-2 was 7.3%. In conclusion, a lower percentage of FH subjects underwent a lipid profile analysis, lipidologist and cardiologist consultations and vascular imaging evaluation after SARS-CoV-2 Italian lockdown.

Published
2021

29. Spread of segmental/multifocal idiopathic adult-onset dystonia to a third body site

Author

Anna Castagna, Francesco Habetswallner, Mario Coletti Moja, Nicola Modugno, Laura Avanzino, Sara Scannapieco, Carmen Terranova, Roberta Pellicciari, Alfredo Berardelli, Francesca Di Biasio, Marcello Mario Mascia, Salvatore Misceo, Marina Ramella, Alberto Albanese, Luca Magistrelli, Roberto Eleopra, Amelia Brigandì, Antonio Pisani, Anna Rita Bentivoglio, Paolo Barone, Gabriella De Joanna, Marcello Esposito, Francesco Bono, Lucia Manzo, Giovanni Cossu, Giovanni Fabbrini, Angelo Pascarella, Sonia Mazzucchi, Brigida Minafra, Vincenzo Moschella, Cesa Scaglione, Tommaso Ercoli, Maurizio Zibetti, Maria Concetta Altavista, Laura Bertolasi, Gina Ferrazzano, Tamara Ialongo, Daniela Cassano, Roberto Ceravolo, Marcello Romano, Paolo Girlanda, Maria Cotelli, Martina Petracca, Giovanni Defazio, Roberto Erro, and Paola Cimino

Subjects
0301 basic medicine, Male, congenital, hereditary, and neonatal diseases and abnormalities, Pediatrics, medicine.medical_specialty, Third body, Spread, Dystonia, Multifocal, Segmental, Upper Extremity, Dystonia Spread, 03 medical and health sciences, 0302 clinical medicine, Aged, Aged, 80 and over, Dystonic Disorders, Female, Humans, Italy, Middle Aged, Neck, Retrospective Studies, Skull, Torticollis, Registries, otorhinolaryngologic diseases, medicine, 80 and over, Family history, Survival analysis, business.industry, Focal dystonia, medicine.disease, Comorbidity, nervous system diseases, Settore MED/26 - NEUROLOGIA, 030104 developmental biology, medicine.anatomical_structure, Neurology, Upper limb, Body region, Neurology (clinical), Geriatrics and Gerontology, business, 030217 neurology & neurosurgery
Abstract

Background Adult-onset focal dystonia can spread to involve one, or less frequently, two additional body regions. Spread of focal dystonia to a third body site is not fully characterized. Materials and methods We retrospectively analyzed data from the Italian Dystonia Registry, enrolling patients with segmental/multifocal dystonia involving at least two parts of the body or more. Survival analysis estimated the relationship between dystonia features and spread to a third body part. Results We identified 340 patients with segmental/multifocal dystonia involving at least two body parts. Spread of dystonia to a third body site occurred in 42/241 patients (17.4%) with focal onset and 10/99 patients (10.1%) with segmental/multifocal dystonia at onset. The former had a greater tendency to spread than patients with segmental/multifocal dystonia at onset. Gender, years of schooling, comorbidity, family history of dystonia/tremor, age at dystonia onset, and disease duration could not predict spread to a third body site. Among patients with focal onset in different body parts (cranial, cervical, and upper limb regions), there was no association between site of focal dystonia onset and risk of spread to a third body site. Discussion and conclusion Spread to a third body site occurs in a relative low percentage of patients with idiopathic adult-onset dystonia affecting two body parts. Regardless of the site of dystonia onset and of other demographic/clinical variables, focal onset seems to confer a greater risk of spread to a third body site in comparison to patients with segmental/multifocal dystonia at onset.

Published
2021

30. A Systematic Review of the Diagnostic Methods of Small Fiber Neuropathies in Rehabilitation

Author

Marcello Romano, Rita Chiaramonte, and Michele Vecchio

Subjects
medicine.medical_specialty, Diagnostic methods, small fiber neuropathy, diagnosis, medicine.medical_treatment, Clinical Biochemistry, systematic reviews, Review, Cochrane Library, Diagnostic tools, Pharmacological treatment, 03 medical and health sciences, 0302 clinical medicine, medicine, Medical physics, 030212 general & internal medicine, Small Fiber Neuropathy, Protocol (science), lcsh:R5-920, Rehabilitation, business.industry, Systematic review, lcsh:Medicine (General), business, 030217 neurology & neurosurgery
Abstract

This systematic review describes the several methods to diagnose and measure the severity of small fiber neuropathies and aims to guide the physician to define all the diagnostic approaches for adopting the best strategies described in the current literature. The search was conducted in PubMed, EMBASE, Cochrane Library and Web of Science. Two reviewers independently reviewed and came to consensus on which articles met inclusion/exclusion criteria. The authors excluded all the duplicates, animals’ studies, and included the English articles in which the diagnostic measures were finalized to assess the effectiveness of rehabilitation and pharmacologic treatment of patients with small fiber neuropathies. The search identified a total of 975 articles with the keywords “small fiber neuropathy” AND “rehabilitation” OR “therapy” OR “treatment”. Seventy-eight selected full-text were analyzed by the reviewers. Forty-one publications met the inclusion criteria and were included in the systematic review. Despite the range of diagnostic tools for the assessment of small fiber neuropathy, other robust trials are needed. In addition, always different diagnostic approaches are used, a unique protocol could be important for the clinicians. More research is needed to build evidence for the best diagnostic methodologies and to delineate a definitive diagnostic protocol.

Published
2020

31. Platelet‑to‑lymphocyte ratio, neutrophil‑to‑lymphocyte ratio and monocyte‑to‑HDL cholesterol ratio as markers of peripheral artery disease in elderly patients

Author

Angela Abate, Salvatore Santo Signorelli, Stefano Selvaggio, Mario Di Guardo, Giuseppe Brugaletta, Caterina Di Guardo, Salvatore Luca, Marcello Romano, Cinzia Musso, and Enzo Vicari

Subjects
0301 basic medicine, Male, medicine.medical_specialty, Lymphocyte, 03 medical and health sciences, chemistry.chemical_compound, Leukocyte Count, Peripheral Arterial Disease, 0302 clinical medicine, Internal medicine, Bayesian multivariate linear regression, Genetics, medicine, Humans, Platelet, Ankle Brachial Index, Neutrophil to lymphocyte ratio, Aged, Aged, 80 and over, business.industry, Cholesterol, Platelet Count, fungi, Cholesterol, HDL, General Medicine, Venous blood, Prognosis, Peripheral, body regions, 030104 developmental biology, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Concomitant, Cardiology, Female, business
Abstract

Solid evidence underlines the pivotal role played by inflammation regarding atherosclerosis. Peripheral artery disease (PAD) is one of atherosclerotic cardiovascular diseases (CVDs), it is highly frequently diagnosed in older individuals. In the present study we carried out an investigation on the association between platelet‑to‑lymphocytes ratio (PLR), neutrophil‑to‑lymphocyte ratio (NLR), monocyte‑to‑HDL cholesterol ratio (MHR) with PAD as favourable markers. We identified 300 subjects aged over 70 years, without any concomitant CVDs. The PLR, NLR and MHR were assessed from peripheral venous blood routinely drawn in the ward during hospitalization. Patients were divided in groups according to ankle brachial index (ABI) value (0.9; 0.9‑0.99; 1‑1.4; 1.4). Higher PLR (P=0.007), NLR (P=0.0001) and MHR (P=0.0001) were associated with 0.9 ABI. Patients with a1.4 ABI showed NLR values higher compared to 0.9l ABI (P0.01). Univariate linear regression analysis demonstrated the direct correlation between increase in PLR (P=0.0023)and MHR (P0.0001) with the decrease in ABI value. In multivariate linear regression analysis including main cardiovascular risk factors we found that PLR, NLR and MHR were independently associated with lower ABI (P=0.0011). Results show and suggest that the elevated PLR, NLR and MHR are related to PAD evaluated with ABI measurement. PLR and MHR seem to be more reliable markers than NLR in PAD. NLR seems to be more related to incompressibility of arterial wall. It is hypothesized that these three indexes may play a role as simple and repetitive markers of PAD.

Published
2020

32. Intranasal midazolam for treating acute respiratory crises in a woman with stiff person syndrome

Author

Marcello Romano, C Tassorelli, Margherita Algeri, Grazia Crescimanno, Enrico Alfonsi, Giuseppe Cosentino, Filippo Brighina, Cosentino G., Romano M., Algeri M., Brighina F., Alfonsi E., Tassorelli C., and Crescimanno G.

Subjects
040301 veterinary sciences, Midazolam, Stiff-Person Syndrome, respiratory crises, Sudden death, stiff person syndrome, midazolam, respiratory crises, 0403 veterinary science, 03 medical and health sciences, Benzodiazepines, 0302 clinical medicine, Medicine, Humans, Stiff syndrome, Respiratory system, Intranasal midazolam, intranasal midazolam, Clinical/Scientific Notes, Administration, Intranasal, Rib cage, business.industry, 04 agricultural and veterinary sciences, Middle Aged, medicine.disease, Trunk, body regions, Dyspnea, Neurology, Anesthesia, Settore MED/26 - Neurologia, Female, Neurology (clinical), business, Respiratory Insufficiency, 030217 neurology & neurosurgery, Stiff person syndrome
Abstract

Stiff person syndrome (SPS) is a rare neurologic disorder characterized by progressively worsening rigidity and spasms of the axial and limb muscles. Dyspnea has been recently recognized as a common symptom in SPS,1 and life-threatening respiratory crises have been occasionally reported and suspected to be responsible for sudden death in these patients.2,3 The pathophysiologic mechanisms of these respiratory manifestations remain unclear. Some authors have hypothesized that rigidity and/or spasm of the muscles of the trunk could prevent normal rib cage movements and excursion of the diaphragm.1

Published
2020

35. Motor and Sensory Features of Cervical Dystonia Subtypes: Data From the Italian Dystonia Registry

Author

Francesca Di Biasio, Roberta Marchese, Giovanni Abbruzzese, Ottavia Baldi, Marcello Esposito, Francesco Silvestre, Girolamo Tescione, Alfredo Berardelli, Giovanni Fabbrini, Gina Ferrazzano, Roberta Pellicciari, Roberto Eleopra, Grazia Devigili, Francesco Bono, Domenico Santangelo, Laura Bertolasi, Maria Concetta Altavista, Vincenzo Moschella, Paolo Barone, Roberto Erro, Alberto Albanese, Cesa Scaglione, Rocco Liguori, Maria Sofia Cotelli, Giovanni Cossu, Roberto Ceravolo, Mario Coletti Moja, Maurizio Zibetti, Antonio Pisani, Martina Petracca, Michele Tinazzi, Luca Maderna, Paolo Girlanda, Luca Magistrelli, Salvatore Misceo, Marcello Romano, Brigida Minafra, Nicola Modugno, Marco Aguggia, Daniela Cassano, Giovanni Defazio, Laura Avanzino, Di Biasio F., Marchese R., Abbruzzese G., Baldi O., Esposito M., Silvestre F., Tescione G., Berardelli A., Fabbrini G., Ferrazzano G., Pellicciari R., Eleopra R., Devigili G., Bono F., Santangelo D., Bertolasi L., Altavista M.C., Moschella V., Barone P., Erro R., Albanese A., Scaglione C., Liguori R., Cotelli M.S., Cossu G., Ceravolo R., Coletti Moja M., Zibetti M., Pisani A., Petracca M., Tinazzi M., Maderna L., Girlanda P., Magistrelli L., Misceo S., Romano M., Minafra B., Modugno N., Aguggia M., Cassano D., Defazio G., and Avanzino L.

Subjects
0301 basic medicine, medicine.medical_specialty, SNi, cervical dystonia, Head tremor, spread, Sensory system, lcsh:RC346-429, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Post-hoc analysis, medicine, pain, Cervical dystonia, Sensory trick, lcsh:Neurology. Diseases of the nervous system, Dystonia, Neck pain, sensory trick, business.industry, medicine.disease, tremor, nervous system diseases, 030104 developmental biology, Neurology, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

Introduction: Cervical dystonia (CD) is one of the most common forms of adult-onset isolated dystonia. Recently, CD has been classified according to the site of onset and spread, in different clinical subgroups, that may represent different clinical entities or pathophysiologic subtypes. In order to support this hypothesis, in this study we have evaluated whether different subgroups of CD, that clinically differ for site of onset and spread, also imply different sensorimotor features. Methods: Clinical and demographic data from 842 patients with CD from the Italian Dystonia Registry were examined. Motor features (head tremor and tremor elsewhere) and sensory features (sensory trick and neck pain) were investigated. We analyzed possible associations between motor and sensory features in CD subgroups [focal neck onset, no spread (FNO-NS); focal neck onset, segmental spread (FNO-SS); focal onset elsewhere with segmental spread to neck (FOE-SS); segmental neck involvement without spread (SNI)]. Results: In FNO-NS, FOE-SS, and SNI subgroups, head tremor was associated with the presence of tremor elsewhere. Sensory trick was associated with pain in patients with FNO-NS and with head tremor in patients with FNO-SS. Conclusion: The frequent association between head tremor and tremor elsewhere may suggest a common pathophysiological mechanism. Two mechanisms may be hypothesized for sensory trick: a gating mechanism attempting to reduce pain and a sensorimotor mechanism attempting to control tremor.

Published
2020

36. Demographic and clinical determinants of neck pain in idiopathic cervical dystonia

Author

Marcello Esposito, Brigida Minafra, Michele Tinazzi, Francesca Di Biasio, Francesco Bono, Martina Petracca, Cesa Scaglione, Anna Castagna, Maurizio Zibetti, Gina Ferrazzano, Marcello Romano, Tommaso Ercoli, Paolo Girlanda, Luca Magistrelli, Maria Cotelli, Nicola Modugno, Roberto Ceravolo, Roberto Eleopra, Giovanni Defazio, Giovanna Squintani, Alberto Albanese, Salvatore Misceo, Luca Maderna, Roberta Pellicciari, Roberto Erro, Maria Concetta Altavista, Laura Bertolasi, Marco Aguggia, Alfredo Berardelli, Francesca Morgante, Giovanni Cossu, Daniela Cassano, Mario Coletti Moja, Antonio Pisani, Paolo Barone, and Marcello Mario Mascia

Subjects
0301 basic medicine, medicine.medical_specialty, Neurology, cervical dystonia, Basal ganglia, Cervical dystonia, Nociception, Pain, Sensory trick, Logistic regression, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, otorhinolaryngologic diseases, Humans, pain, nociception, Biological Psychiatry, Demography, Neck Pain, Dystonic Disorders, Torticollis, Dystonia, Neck pain, sensory trick, business.industry, medicine.disease, nervous system diseases, Settore MED/26 - NEUROLOGIA, Psychiatry and Mental health, 030104 developmental biology, basal ganglia, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

Cervical dystonia is associated with neck pain in a significant proportion of cases, but the mechanisms underlying pain are largely unknown. In this exploratory study, we compared demographic and clinical variables in cervical dystonia patients with and without neck pain from the Italian Dystonia Registry. Univariable and multivariable logistic regression analysis indicated a higher frequency of sensory trick and a lower educational level among patients with pain.

Published
2020

37. Does acute peripheral trauma contribute to idiopathic adult-onset dystonia?

Author

Francesca Di Biasio, Roberto Ceravolo, Giovanni Fabbrini, Valentina Durastanti, Fiore Manganelli, Marcello Esposito, Maria Concetta Altavista, Marcello Mario Mascia, Nicola Tambasco, Alberto Albanese, Luca Maderna, Roberta Pellicciari, Cesa Scaglione, Tommaso Ercoli, Anna Castagna, Stefania Lalli, Marcello Romano, Paolo Girlanda, Giulio Demonte, Michele Tinazzi, Alfredo Berardelli, Francesca Morgante, Laura Bertolasi, Maria Cotelli, Antonio Pisani, Marinella Turla, Valentina Oppo, Marco Aguggia, Paolo Barone, Giovanni Cossu, Nicola Modugno, Francesco Silvestre, Maurizio Zibetti, Salvatore Misceo, Roberto Eleopra, Grazia Devigili, Giulia Di Lazzaro, Roberta Marchese, Giovanna Squintani, Gina Ferrazzano, Daniela Cassano, Luca Magistrelli, Domenico Santangelo, P. Barbero, Sonia Mazzucchi, Giovanni Defazio, Roberto Erro, Francesco Bono, Brigida Minafra, Martina Petracca, Anna Rita Bentivoglio, Mario Coletti Moja, Laura Avanzino, Defazio, G., Fabbrini, G., Erro, R., Albanese, A., Barone, P., Zibetti, M., Esposito, M., Pellicciari, R., Avanzino, L., Bono, F., Eleopra, R., Bertolasi, L., Altavista, M. C., Cotelli, M. S., Ceravolo, R., Scaglione, C., Bentivoglio, A. R., Cossu, G., Coletti Moja, M., Girlanda, P., Misceo, S., Pisani, A., Mascia, M. M., Ercoli, T., Tinazzi, M., Maderna, L., Minafra, B., Magistrelli, L., Romano, M., Aguggia, M., Tambasco, N., Castagna, A., Cassano, D., Berardelli, A., Ferrazzano, G., Lalli, S., Silvestre, F., Manganelli, F., Di Biasio, F., Marchese, R., Demonte, G., Santangelo, D., Devigili, G., Durastanti, V., Turla, M., Mazzucchi, S., Petracca, M., Oppo, V., Barbero, P., Morgante, F., Di Lazzaro, G., Squintani, G., and Modugno, N.

Subjects
0301 basic medicine, Male, congenital, hereditary, and neonatal diseases and abnormalities, Pediatrics, medicine.medical_specialty, Injury, Trauma, 03 medical and health sciences, 0302 clinical medicine, Dystonia, Acute Disease, Aged, Dystonic Disorders, Female, Humans, Italy, Middle Aged, Peripheral Nerve Injuries, Retrospective Studies, Risk Factors, Registries, otorhinolaryngologic diseases, Medicine, Risk factor, Medical attention, Secondary Dystonia, business.industry, medicine.disease, nervous system diseases, Peripheral, Settore MED/26 - NEUROLOGIA, 030104 developmental biology, Neurology, Neurology (clinical), Geriatrics and Gerontology, business, Acute trauma, 030217 neurology & neurosurgery
Abstract

Background Acute peripheral trauma is a controversial risk factor for idiopathic dystonia. Materials and methods We retrospectively analyzed data from the Italian Dystonia Registry regarding the occurrence of acute peripheral trauma severe enough to require medical attention in 1382 patients with adult-onset idiopathic dystonia and 200 patients with acquired adult-onset dystonia. Results Patients with idiopathic and acquired dystonia showed a similar burden of peripheral trauma in terms of the number of patients who experienced trauma (115/1382 vs. 12/200, p = 0.3) and the overall number of injuries (145 for the 1382 idiopathic patients and 14 for the 200 patients with secondary dystonia, p = 0.2). Most traumas occurred before the onset of idiopathic or secondary dystonia but only a minority of such injuries (14 in the idiopathic group, 2 in the acquired group, p = 0.6) affected the same body part as that affected by dystonia. In the idiopathic group, the elapsed time between trauma and dystonia onset was 8.1 ± 9.2 years; only six of the 145 traumas (4.1%) experienced by 5/1382 idiopathic patients (0.36%) occurred one year or less before dystonia onset; in the acquired dystonia group, the two patients experienced prior trauma to the dystonic body part 5 and 6 years before dystonia development. Discussion and conclusion Our data suggest that the contribution of peripheral acute trauma to idiopathic dystonia is negligible, if anything, and likely involves only a small subset of patients.

Published
2020

38. Time-optimal control of linear time invariant systems between two arbitrary states

Author

Marcello Romano, Fabio Curti, and Mechanical and Aerospace Engineering (MAE)

Subjects
0209 industrial biotechnology, Optimal Control, Boundary (topology), 02 engineering and technology, Optimal Control, Exact solutions, LTI system theory, Double integrator, aerospace engineering, minimum-time no-rest to no-rest control, analytic design, double integrator, 020901 industrial engineering & automation, 0202 electrical engineering, electronic engineering, information engineering, Applied mathematics, Electrical and Electronic Engineering, Control (linguistics), Exact solutions, Mathematics, Rest (physics), 020208 electrical & electronic engineering, State (functional analysis), No-rest to no-rest control, Optimal control, Transformation (function), Control and Systems Engineering
Abstract

The article of record as published may be found at https://doi.org/10.1016/j.automatica.2020.109151 New results are presented for the problem of minimum-time control of a general linear time-invariant normal system evolving from an arbitrary initial state to an arbitrary final state (no-rest to no-rest problem), subjected to bound controls. In particular, it is demonstrated that the above problem is equivalent to an associated minimum-time control problem of transferring the same system from a particular initial state to the state-space origin (no-rest to rest problem), where that particular initial state is related to the boundary states of the original problem through a transformation of the state-space onto itself. If the optimal control history that transfers the system from an arbitrary initial state to the origin is known, either analytically or numerically, then the new results provide a method to solve the problem of minimum-time control between two arbitrary states and moreover, to find all of the extremal controlled trajectories. A criterion of existence is also given for the solution of the minimum-time control between two arbitrary states. Finally, the analytic solution is presented for the minimum-time control of the double integrator between arbitrary states. That solution provides a significant example of applying the new results.

Published
2020

39. Platelet to lymphocyte ratio, neutrophil to lymphocyte ratio and monocyte to HDL cholesterol ratio as markers of peripheral artery disease in elderly patients

Author

Selvaggio, Stefano, Angela, Abate, Giuseppe, Brugaletta, Cinzia, Musso, DI GUARDO, Mario, Caterina Di Guardo, Vicari, Enzo Saretto, Marcello, Romano, Salvatore, Luca, and Signorelli, Salvatore

Subjects
neutrophil‑to‑lymphocyte ratio, monocyte‑to‑HDL cholesterol ratio, inflammation, peripheral artery disease, platelet‑to‑lymphocyte ratio, neutrophil‑to‑lymphocyte ratio, monocyte‑to‑HDL cholesterol ratio, inflammation, elderly, ankle‑brachial index, atherosclerosis, platelet‑to‑lymphocyte ratio, atherosclerosis, peripheral artery disease, ankle‑brachial index, elderly
Published
2020

41. Expert recommendations for diagnosing cervical, oromandibular, and limb dystonia

Author

Alberto Albanese, Giovanni Fabbrini, Marcello Esposito, Claudio Pacchetti, Francesco Bono, Giovanni Defazio, Roberta Pellicciari, Anna Rita Bentivoglio, Giovanni Abbruzzese, Alfredo Berardelli, Francesca Morgante, Marcello Romano, Laura Fadda, Mario Coletti Moja, Paolo Girlanda, Cesa Scaglione, Leonardo Lopiano, Defazio, G., Albanese, A., Pellicciari, R., Scaglione, C. L., Esposito, M., Morgante, F., Abbruzzese, G., Bentivoglio, A. R., Bono, F., Coletti Moja, M., Fabbrini, G., Girlanda, P., Lopiano, L., Pacchetti, C., Romano, M., Fadda, L., and Berardelli, A.

Subjects
congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Neurology, Pseudodystonia, Blepharospasm, Dermatology, Limb dystonia, Neurologist, 03 medical and health sciences, 0302 clinical medicine, Physical medicine and rehabilitation, Diagnosis, otorhinolaryngologic diseases, medicine, Movement Disorder, Humans, Neurologists, 030212 general & internal medicine, Sensory trick, Expert Testimony, Laryngeal dystonia, Torticollis, Neuroradiology, Dystonia, Movement Disorders, business.industry, General Medicine, Focal dystonia, Dystonic Disorder, Dystonic Disorders, Italy, 2708, Neurology (clinical), Psychiatry and Mental Health, medicine.disease, nervous system diseases, Settore MED/26 - NEUROLOGIA, Psychiatry and Mental health, diagnosis, focal dystonia, pseudodystonia, neurology (clinical), psychiatry and mental health, medicine.symptom, business, 030217 neurology & neurosurgery, Diagnosi, Human
Abstract

Background: Diagnosis of focal dystonia is based on clinical grounds and is therefore open to bias. To date, diagnostic guidelines have been only proposed for blepharospasm and laryngeal dystonia. To provide practical guidance for clinicians with less expertise in dystonia, a group of Italian Movement Disorder experts formulated clinical diagnostic recommendations for cervical, oromandibular, and limb dystonia. Methods: A panel of four neurologists generated a list of clinical items related to the motor phenomenology of the examined focal dystonias and a list of clinical features characterizing neurological/non-neurological conditions mimicking dystonia. Thereafter, ten additional expert neurologists assessed the diagnostic relevance of the selected features and the content validity ratio was calculated. The clinical features reaching a content validity ratio > 0.5 contributed to the final recommendations. Results: The recommendations retained patterned and repetitive movements/postures as the core feature of dystonia in different body parts. If present, a sensory trick confirmed diagnosis of dystonia. In the patients who did not manifest sensory trick, active exclusion of clinical features related to conditions mimicking dystonia (features that would be expected to be absent in dystonia) would be necessary for dystonia to be diagnosed. Discussion: Although reliability, sensitivity, and specificity of the recommendations are yet to be demonstrated, information from the present study would hopefully facilitate diagnostic approach to focal dystonias in the clinical practice and would be the basis for future validated diagnostic guidelines.

Published
2018

42. Spread of dystonia in patients with idiopathic adult-onset laryngeal dystonia

Author

Giovanni Fabbrini, Ugo Cesari, Marcello Esposito, Anna Rita Bentivoglio, Giovanni Defazio, Alfredo Berardelli, Cesa Scaglione, Maurizio Zibetti, Marinella Turla, Marcello Romano, Laura Fadda, Roberto Erro, Tommaso Schirinzi, Stefano Peluso, Giovanni Cossu, Laura Avanzino, M. Coletti Moja, Roberto Eleopra, Paolo Barone, Gina Ferrazzano, Francesca Morgante, Brigida Minafra, Martina Petracca, Angelo Fabio Gigante, Esposito, M., Fabbrini, G., Ferrazzano, G., Berardelli, A., Peluso, S., Cesari, U., Gigante, A. F., Bentivoglio, A. R., Petracca, M., Erro, R., Barone, P., Schirinzi, T., Eleopra, R., Avanzino, L., Romano, M., Scaglione, C. L., Cossu, G., Morgante, F., Minafra, B., Zibetti, M., Coletti Moja, M., Turla, M., Fadda, L., and Defazio, G.

Subjects
Male, Registrie, 0301 basic medicine, Larynx, Pediatrics, adult focal dystonia, laryngeal dystonia, spread, Age Factors, Age of Onset, Aged, Aged, 80 and over, Disease Progression, Dystonia, Dystonic Disorders, Female, Humans, Italy, Laryngeal Diseases, Middle Aged, Registries, Sex Factors, 0302 clinical medicine, 80 and over, Age Factor, Laryngeal dystonia, Dystonic Disorder, Italian population, Settore MED/26 - NEUROLOGIA, medicine.anatomical_structure, Laryngeal Disease, Neurology, Body region, medicine.symptom, Human, medicine.medical_specialty, Blepharospasm, 03 medical and health sciences, otorhinolaryngologic diseases, medicine, In patient, Neurology (clinical), business.industry, medicine.disease, 030104 developmental biology, business, 030217 neurology & neurosurgery, Clinical progression
Abstract

BACKGROUND AND PURPOSE: Adult-onset laryngeal dystonia (LD) can be isolated or can be associated with dystonia in other body parts. Combined forms can be segmental at the onset or can result from dystonia spread to or from the larynx. The aim of this study was to identify the main clinical and demographic features of adult-onset idiopathic LD in an Italian population with special focus on dystonia spread. METHODS: Data were obtained from the Italian Dystonia Registry (IDR) produced by 37 Italian institutions. Clinical and demographic data of 71 patients with idiopathic adult-onset LD were extracted from a pool of 1131 subjects included in the IDR. RESULTS: Fifty of 71 patients presented a laryngeal focal onset; the remaining subjects had onset in other body regions and later laryngeal spread. The two groups did not show significant differences of demographic features. 32% of patients with laryngeal onset reported spread to contiguous body regions afterwards and in most cases (12 of 16 subjects) dystonia started to spread within 1 year from the onset. LD patients who remained focal and those who had dystonia spread did not show other differences. CONCLUSIONS: Data from IDR show that dystonic patients with focal laryngeal onset will present spread in almost one-third of cases. Spread from the larynx occurs early and is directed to contiguous body regions showing similarities with clinical progression of blepharospasm. This study gives a new accurate description of LD phenomenology that may contribute to improving the comprehension of dystonia pathophysiology.

Published
2018

43. Reachability Analysis of Planar Spacecraft Docking with Rotating Body in Close Proximity

Author

Costantinos Zagaris and Marcello Romano

Subjects
0209 industrial biotechnology, Computer science, Aerospace Engineering, 02 engineering and technology, Topology, law.invention, LTI system theory, 020901 industrial engineering & automation, Docking (dog), Planar, 0203 mechanical engineering, Reachability, law, Cartesian coordinate system, Electrical and Electronic Engineering, MATLAB, computer.programming_language, 020301 aerospace & aeronautics, Spacecraft, business.industry, Applied Mathematics, Optimal control, Space and Planetary Science, Control and Systems Engineering, business, computer
Published
2018

44. Laboratory experiments of resident space object capture by a spacecraft–manipulator system

Author

Jerry V. Drew, Josep Virgili-Llop, Richard Zappulla, and Marcello Romano

Subjects
Rest (physics), Guidance and control, Hardware-in-the-loop, Space robotics, 020301 aerospace & aeronautics, 0209 industrial biotechnology, Engineering, Spacecraft, Plane (geometry), business.industry, Base (geometry), Hardware-in-the-loop simulation, Aerospace Engineering, Control engineering, 02 engineering and technology, Object (computer science), Set (abstract data type), 020901 industrial engineering & automation, 0203 mechanical engineering, Control theory, business, Simulation
Abstract

A set of laboratory experiments are conducted to demonstrate the autonomous capture of a simulated resident space object by a simulated spacecraft equipped with a robotic manipulator. A planar air-bearing test bed provides a quasi-weightless and drag-free dynamic environment on a plane. To control the chaser's base, floating, flying, and rotation-flying control approaches are implemented and compared. A resolved-motion-rate controller is used to control the manipulator's joints. Using these control methods a floating object at rest is successfully captured. Furthermore, the capture of a floating and rotating object is demonstrated using a flying base control approach. The originality of these experiments comes from the remarkably high dynamic coupling of the spacecraft–manipulator system used. Emphasis is given to the guidance and control problems, with the relative navigation problem being left outside the scope of this effort.

Published
2017

45. Fast and Near-Optimal Guidance for Docking to Uncontrolled Spacecraft

Author

Marco Ciarcià, Marcello Romano, Jacopo Ventura, Ulrich Walter, Naval Postgraduate School, and Mechanical and Aerospace Engineering (MAE)

Subjects
020301 aerospace & aeronautics, 0209 industrial biotechnology, Engineering, Optimization problem, Spacecraft, business.industry, Applied Mathematics, Aerospace Engineering, ComputerApplications_COMPUTERSINOTHERSYSTEMS, 02 engineering and technology, Trajectory optimization, Optimal control, System dynamics, Nonlinear programming, 020901 industrial engineering & automation, 0203 mechanical engineering, Space and Planetary Science, Control and Systems Engineering, Control theory, Circular orbit, Electrical and Electronic Engineering, Guidance system, business
Abstract

The article of record as published may be found at https://doi.org/10.2514/1.G001843 This paper proposes a guidance scheme for autonomous docking between a controlled spacecraft and an uncontrolled tumbling target in circular orbit. The onboard trajectory planning consists of a direct optimization method based on the inversion of the system dynamics. The trajectory components of the controlled spacecraft are imposed by using polynomial functions. Some of the polynomial coefficients are constrained to satisfy path constraints, whereas the remaining coefficients are varied parameters to be optimized. The optimal control problem is converted into a nonlinear programming problem by inverting the system dynamics. The proposed guidance scheme, based on the closed-loop implementation of this optimization problem, is applied to several scenarios. The resulting trajectories closely match the solutions of the correspondent optimal control problems. The guidance scheme is shown to perform precise maneuvers in most maneuvering situations, even in the presence of orbital perturbations. The sensitivity analysis to system uncertainties shows that the guidance is sensitive to noise on the target angular velocity, being the critical disturbance for this type of maneuvers.

Published
2017

46. Spread of segmental/multifocal idiopathic adult-onset dystonia to a third body site, data from the Italian dystonia registry

Author

Roberto Eleopra, Lucia Manzo, Alfredo Berardelli, Marcello Esposito, Laura Avanzino, Francesca Di Biasio, Luca Magistrelli, Carmen Terranova, Antonio Pisani, Anna Castagna, Alberto Albanese, Maurizio Zibetti, Salvatore Misceo, Marcello Romano, Paolo Girlanda, Marcello Mario Mascia, Roberto Ceravolo, Laura Bertolasi, Anna Rita Bentivoglio, Roberta Pellicciari, Maria Cotelli, Gabriella De Joanna, Cesa Scaglione, Giovanni Fabbrini, Maria Concetta Altavista, Tommaso Ercoli, Giovanni Defazio, Roberto Erro, Nicola Modugno, Giovanni Cossu, Daniela Cassano, Francesco Bono, Martina Petracca, Paolo Barone, Mario Coletti Moja, and Brigida Minafra

Subjects
Dystonia, Third body, Pediatrics, medicine.medical_specialty, Neurology, business.industry, medicine, Neurology (clinical), medicine.disease, business
Published
2021

47. Aerodynamic Three-Axis Attitude Stabilization of a Spacecraft by Center-of-Mass Shifting

Author

Simone Chesi, Marcello Romano, Qi Gong, Naval Postgraduate School, and Mechanical and Aerospace Engineering (MAE)

Subjects
Physics, 020301 aerospace & aeronautics, Spacecraft, business.industry, Applied Mathematics, Aerospace Engineering, 02 engineering and technology, Linear-quadratic regulator, Aerodynamics, 01 natural sciences, 0203 mechanical engineering, Center of pressure (terrestrial locomotion), Space and Planetary Science, Control and Systems Engineering, Control system, Physics::Space Physics, 0103 physical sciences, Astrophysics::Earth and Planetary Astrophysics, Center of mass, Electrical and Electronic Engineering, Aerospace engineering, business, Quaternion, Actuator, 010303 astronomy & astrophysics
Abstract

The article of record as published may be found at http://doi.org/10.2514/1.G002460 This paper proposes a spacecraft attitude control technique based on the use of center-of-mass shifting. In particular, the position vector of the spacecraft’s center of pressure with respect to the center of mass is modified by shifting masses, which results in a change of the aerodynamic torque vector within the plane perpendicular to the aerodynamic drag. This results in an underactuated control system. To achieve full three-axis stabilization, additional actuators (either a reaction wheel or a set of magnetic torquers) are considered. An adaptive nonlinear attitude regulation control law was designed in order to obtain an ideal control torque based on the Lyapunov method and its stability was proven by LaSalle’s invariance principle. The control torque was then allocated to steer three shifting masses and either a reaction wheel or three magnetic torquers. Numerical simulations are reported, confirming the analytic results. The proposed method decreases the residual oscillation error typically associated with magnetic controlled attitude in the presence of residual aerodynamic torque. Therefore, it might contribute to achieve higher pointing accuracy of small spacecraft in low Earth orbit.

Published
2017

48. Role of Ultrasonography in Acute Appendicitis of the Elderly. A Pictorial Essay

Author

Marco Tana, Marcello Romano, Cosima Schiavone, Claudio Tana, Mauro Silingardi, and Giovanni Iannetti

Subjects
03 medical and health sciences, medicine.medical_specialty, 0302 clinical medicine, business.industry, 030220 oncology & carcinogenesis, Acute appendicitis, medicine, 030211 gastroenterology & hepatology, Radiology, Nuclear Medicine and imaging, Radiology, Ultrasonography, business
Published
2017

49. Correction to: Demographic and clinical determinants of neck pain in idiopathic cervical dystonia

Author

Giovanni Cossu, Francesca Di Biasio, Marcello Esposito, Anna Castagna, Alberto Albanese, Antonio Pisani, Paolo Barone, Giovanni Defazio, Daniela Cassano, Nicola Modugno, Michele Tinazzi, Martina Petracca, Salvatore Misceo, Cesa Scaglione, Tommaso Ercoli, Roberto Erro, Luca Maderna, Roberta Pellicciari, Laura Bertolasi, Francesca Morgante, Marco Aguggia, Roberto Ceravolo, Francesco Bono, Maurizio Zibetti, Brigida Minafra, Marcello Romano, Gina Ferrazzano, Paolo Girlanda, Marcello Mario Mascia, Maria Cotelli, Roberto Eleopra, Mario Coletti Moja, Alfredo Berardelli, Maria Concetta Altavista, Giovanna Squintani, and Luca Magistrelli

Subjects
medicine.medical_specialty, Pediatrics, Neck pain, Neurology, business.industry, MEDLINE, medicine.disease, Psychiatry and Mental health, Medicine, Neurology (clinical), Cervical dystonia, medicine.symptom, business, Biological Psychiatry
Published
2020

50. Simultaneous Capture and Detumble of a Resident Space Object by a Free-Flying Spacecraft-Manipulator System

Author

Josep Virgili-Llop, Marcello Romano, Naval Postgraduate School (U.S.), and Mechanical and Aerospace Engineering (MAE)

Subjects
Angular momentum, sequential convex programming, convex optimization, Computer science, lcsh:Mechanical engineering and machinery, Active debris removal, Computational guidance and control, Convex optimization, Hardware-in-the-loop experiments, On-orbit servicing, Sequential convex programming, Spacecraft robotics, Constraint (computer-aided design), ComputerApplications_COMPUTERSINOTHERSYSTEMS, lcsh:QA75.5-76.95, Set (abstract data type), Computer Science::Robotics, spacecraft robotics, Position (vector), Control theory, Artificial Intelligence, lcsh:TJ1-1570, computational guidance and control, Original Research, Robotics and AI, Spacecraft, business.industry, GRASP, Computer Science Applications, on-orbit servicing, Terminal (electronics), lcsh:Electronic computers. Computer science, hardware-in-the-loop experiments, business, active debris removal
Abstract

The article of record as published may be found at https://doi.org/10.3389/frobt.2019.00014 A maneuver to capture and detumble an orbiting space object using a chaser spacecraft equipped with a robotic manipulator is presented. In the proposed maneuver, the capture and detumble objectives are integrated into a unified set of terminal constraints. Terminal constraints on the end-effector’s position and velocity ensure a successful capture, and a terminal constraint on the chaser’s momenta ensures a post-capture chaser-target system with zero angular momentum. The manipulator motion required to achieve a smooth, impact-free grasp is gradually stopped after capture, equalizing the momenta across all bodies, rigidly connecting the two vehicles, and completing the detumble of the newly formed chaser-target system without further actuation. To guide this maneuver, an optimization-based approach that enforces the capture and detumble terminal constraints, avoids collisions, and satisfies actuation limits is used. The solution to the guidance problem is obtained by solving a collection of convex programming problems, making the proposed guidance approach suitable for onboard implementation and real-time use. This simultaneous capture and detumble maneuver is evaluated through numerical simulations and hardware-in-the-loop experiments. Videos of the numerically simulated and experimentally demonstrated maneuvers are included as Supplementary Material.

Published
2019

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