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We discuss the consequences of the quantum uncertainty on the spectrum of the electron emitted by the $\beta$-processes of a tritium atom bound to a graphene sheet. We analyze quantitatively the issue recently raised in [Cheipesh et al., Phys. Rev. D 104, 116004 (2021)], and discuss the relevant time scales and the degrees of freedom that can contribute to the intrinsic spread in the electron energy. We perform careful calculations of the potential between tritium and graphene with different coverages and geometries. With this at hand, we propose possible avenues to mitigate the effect of the quantum uncertainty., Comment: 14 pages, 5 figures

The PTOLEMY transverse drift filter is a new concept to enable precision analysis of the energy spectrum of electrons near the tritium beta-decay endpoint. This paper details the implementation and optimization methods for successful operation of the filter. We present the first demonstrator that produces the required magnetic field properties with an iron return-flux magnet. Two methods for the setting of filter electrode voltages are detailed. The challenges of low-energy electron transport in cases of low field are discussed, such as the growth of the cyclotron radius with decreasing magnetic field, which puts a ceiling on filter performance relative to fixed filter dimensions. Additionally, low pitch angle trajectories are dominated by motion parallel to the magnetic field lines and introduce non-adiabatic conditions and curvature drift. To minimize these effects and maximize electron acceptance into the filter, we present a three-potential-well design to simultaneously drain the parallel and transverse kinetic energies throughout the length of the filter. These optimizations are shown, in simulation, to achieve low-energy electron transport from a 1 T iron core (or 3 T superconducting) starting field with initial kinetic energy of 18.6 keV drained to, 29 pages, 25 figures

This study was aimed to analyze the commonalities and distinctions of voltage-gated sodium channels, Nav1.2, Nav1.6, in neurodevelopmental disorders. An observational study was performed including two patients with neurodevelopmental disorders. The demographic, electroclinical, genetic, and neuropsychological characteristics were analyzed and compared with each other and then with the subjects carrying the same genetic variants reported in the literature. The clinical features of one of them argued for autism spectrum disorder and developmental delay, the other for intellectual disability, diagnoses confirmed by the neuropsychological assessment. The first patient was a carrier of SCN2A (p.R379H) variant while the second was carrier of SCN8A (p.E936K) variant, both involving the pore loop of the two channels. The results of this study suggest that the neurodevelopmental disorders without overt epilepsy of both patients can be the consequences of loss of function of Nav1.2/Nav1.6 channels. Notably, the SCN2A variant, with an earlier expression timing in brain development, resulted in a more severe phenotype as autism spectrum disorder and developmental delay, while the SCN8A variant, with a later expression timing, resulted in a less severe phenotype as intellectual disability.

The integrated interpretation of different types of data, consisting of a detailed Digital Terrain Model, field structural and morphotectonic observations, high resolution seismic data, seismological and Synthetic Aperture Radar interferometry information (vertical and horizontal movements), associated with a review of the available literature, has allowed to analyze the shallow expression of the regional-scale Petilia-Sosti Shear Zone (PSSZ). It is one of the major NW-trending tectonic lineaments affecting the Calabrian Arc and is characterized by a present-day tectonic and gravity-driven deformation. This study investigated the portion of the PSSZ between the offshore Crotone Peninsula, located along the Ionian sea of Calabria, and the central part of the Sila Massif. A complex tectonic history is documented since middle Miocene onward for the PSSZ. It consists of an alternation of sinistral and dextral transpressional and transtensional tectonic phases correlated with the geodynamic events occurred during the SE migration of the Calabrian Arc. The shallow expression of the investigated part of the PSSZ consists of a roughly 14 km wide, ca. 80 km long NW-trending tectonic zone including synthetic NW- to NNW-trending faults and N-NE antithetic minor structures. The main identified NW-trending faults, which show a development between 30 and 50 km, are the Sila and Lakes faults in the Sila Massif, and the Marcedusa-Steccato, Fosso Umbro and Tacina faults located in the SW part of the Crotone Basin and in its offshore area. Currently, the fault segments of the Sila Massif exhibit a prevailing normal kinematics with a left-lateral component, whereas a more complex geological framework occurs in the south-western part of the onshore-offshore Crotone Basin. The latter is dominated by gravity-driven movements, associated with the SE migration of the Crotone Megalandslide and with the regional uplift of Calabria, whereas normal kinematics with a small left-lateral component of movement, locally replaced by reverse/transpressional tectonics, was observed along the southern coast in the late Pleistocene deposits of the Le Castella marine terrace. The seismological data highlight that some strong earthquakes occurred in 1638, 1744 and 1832, with magnitude Mw between 5.7 and 6.8, might be associated with the Lakes, Fosso Umbro and Tacina faults respectively. In this frame, the PSSZ is proposed as a new potential NW-oriented active composite seismogenic source for the central-northern Calabria.

Mowat-Wilson syndrome is a genetic disorder associated with a variable phenotype including peculiar facial features associated with intellectual disability, epilepsy, language impairment, and multiple congenital anomalies caused by heterozygous mutation of the ZEB2 gene. The ZEB2 protein is a complex transcription factor that encompasses multiple functional domains that interact with the regulatory regions of target genes including those involved in brain development. Recently, it has been documented that ZEB2 regulates the differentiation of interneuron progenitors migrating from the medial ganglionic eminence to cortical layers by repression of the Nkx2-1 homeobox transcription factor. It has therefore been suggested that the deficit in ZEB2 may induce an imbalance of neuronal inhibition/excitation leading to epileptic seizures. Given the phenotypic variability of Mowat-Wilson syndrome, to date, a distinctive genotype-phenotype correlation has not been delineated. Here, we report a patient with a severe phenotype of Mowat-Wilson syndrome, associated with a novel heterozygous de novo frame-shift variant in the ZEB2 gene, as well as an additional novel heterozygous missense variant in the SCN1A gene, the mutation of which is known to affect NaV1.1-mediated sodium current in GABAergic interneurons. We hypothesize that the severe neurological phenotype of our patient may be influenced by the coexistence of both genetic mutations. [Published with video sequence].

The submerged sill in the Strait of Messina, which is located today at a minimum depth of 81 m below sea level (bsl), represents the only land connection between Sicily and mainland Italy (and thus Europe) during the last lowstand when the sea level locally stood at about 126 m bsl. Today, the sea crossing to Sicily, although it is less than 4 km at the narrowest point, faces hazardous sea conditions, made famous by the myth of Scylla and Charybdis. Through a multidisciplinary research project, we document the timing and mode of emergence of this land connection during the last 40 kyr. The integrated analysis takes into consideration morphobathymetric and lithological data, and relative sea-level change (both isostatic and tectonic), resulting in the hypothesis that a continental land bridge lasted for at least 500 years between 21.5 and 20 cal ka BP. The emergence may have occurred over an even longer time span if one allows for seafloor erosion by marine currents that have lowered the seabed since the Last Glacial Maximum (LGM). Modelling of palaeotidal velocities shows that sea crossings when sea level was lower than present would have faced even stronger and more hazardous sea currents than today, supporting the hypothesis that earliest human entry into Sicily most probably took place on foot during the period when the sill emerged as dry land. This hypothesis is compared with an analysis of Pleistocene vertebrate faunas in Sicily and mainland Italy, including a new radiocarbon date on bone collagen of an Equus hydruntinus specimen from Grotta di San Teodoro (23–21 cal ka BP), the dispersal abilities of the various animal species involved, particularly their swimming abilities, and the Palaeolithic archaeological record, all of which support the hypothesis of a relatively late land-based colonization of Sicily by Homo sapiens.

We present the analyses relative to the measurements of the Higgs couplings and properties, carried out in the context of the FCC-hh detector performance study group.

We propose to achieve the proof-of-principle of the PTOLEMY project to directly detect the Cosmic Neutrino Background (CNB). Each of the technological challenges described in [1,2] will be targeted and hopefully solved by the use of the latest experimental developments and profiting from the low background environment provided by the LNGS underground site. The first phase will focus on the graphene technology for a tritium target and the demonstration of TES microcalorimetry with an energy resolution of better than 0.05 eV for low energy electrons. These technologies will be evaluated using the PTOLEMY prototype, proposed for underground installation, using precision HV controls to step down the kinematic energy of endpoint electrons to match the calorimeter dynamic range and rate capabilities. The second phase will produce a novel implementation of the EM filter that is scalable to the full target size and which demonstrates intrinsic triggering capability for selecting endpoint electrons. Concurrent with the CNB program, we plan to exploit and develop the unique properties of graphene to implement an intermediate program for direct directional detection of MeV dark matter [3,4]. This program will evaluate the radio-purity and scalability of the graphene fabrication process with the goal of using recently identified ultra-high radio-purity CO2 sources. The direct detection of the CNB is a snapshot of early universe dynamics recorded by the thermal relic neutrino yield taken at a time that predates the epochs of Big Bang Nucleosynthesis, the Cosmic Microwave Background and the recession of galaxies (Hubble Expansion). Big Bang neutrinos are believed to have a central role in the evolution of the Universe and a direct measurement with PTOLEMY will unequivocally establish the extent to which these predictions match present-day neutrino densities.

The $\alpha+d\rightarrow\, ^6{\rm Li}+\gamma$ radiative capture is studied in order to predict the $^6$Li primordial abundance. Within a two-body framework, the $\alpha$ particle and the deuteron are considered the structureless constituents of $^6$Li. Five $\alpha+d$ potentials are used to solve the two-body problem: four of them are taken from the literature, only one having also a tensor component. A fifth model is here constructed in order to reproduce, besides the $^6$Li static properties as binding energy, magnetic dipole and electric quadrupole moments, also the $S$-state asymptotic normalization coefficient (ANC). The two-body bound and scattering problem is solved with different techniques, in order to minimize the numerical uncertainty of the present results. The long-wavelength approximation is used, and therefore only the electric dipole and quadrupole operators are retained. The astrophysical $S$-factor is found to be significantly sensitive to the ANC, but in all the cases in good agreement with the available experimental data. The theoretical uncertainty has been estimated of the order of few % when the potentials which reproduce the ANC are considered, but increases up to $\simeq 20$ % when all the five potential models are retained. The effect of this $S$-factor prediction on the $^6$Li primordial abundance is studied, using the public code PArthENoPE. For the five models considered here we find $^6{\rm Li}/$H$ = (0.9 - 1.8) \times 10^{-14}$, with the baryon density parameter in the 3-$\sigma$ range of Planck 2015 analysis, $\Omega_b h^2= 0.02226 \pm 0.00023$., Comment: 26 pages, 9 figures

We present a comprehensive review of keV-scale sterile neutrino Dark Matter, collecting views and insights from all disciplines involved - cosmology, astrophysics, nuclear, and particle physics - in each case viewed from both theoretical and experimental/observational perspectives. After reviewing the role of active neutrinos in particle physics, astrophysics, and cosmology, we focus on sterile neutrinos in the context of the Dark Matter puzzle. Here, we first review the physics motivation for sterile neutrino Dark Matter, based on challenges and tensions in purely cold Dark Matter scenarios. We then round out the discussion by critically summarizing all known constraints on sterile neutrino Dark Matter arising from astrophysical observations, laboratory experiments, and theoretical considerations. In this context, we provide a balanced discourse on the possibly positive signal from X-ray observations. Another focus of the paper concerns the construction of particle physics models, aiming to explain how sterile neutrinos of keV-scale masses could arise in concrete settings beyond the Standard Model of elementary particle physics. The paper ends with an extensive review of current and future astrophysical and laboratory searches, highlighting new ideas and their experimental challenges, as well as future perspectives for the discovery of sterile neutrinos.

The $��+d\rightarrow\, ^6{\rm Li}+��$ radiative capture is studied in order to predict the $^6$Li primordial abundance. Within a two-body framework, the $��$ particle and the deuteron are considered the structureless constituents of $^6$Li. Five $��+d$ potentials are used to solve the two-body problem: four of them are taken from the literature, only one having also a tensor component. A fifth model is here constructed in order to reproduce, besides the $^6$Li static properties as binding energy, magnetic dipole and electric quadrupole moments, also the $S$-state asymptotic normalization coefficient (ANC). The two-body bound and scattering problem is solved with different techniques, in order to minimize the numerical uncertainty of the present results. The long-wavelength approximation is used, and therefore only the electric dipole and quadrupole operators are retained. The astrophysical $S$-factor is found to be significantly sensitive to the ANC, but in all the cases in good agreement with the available experimental data. The theoretical uncertainty has been estimated of the order of few % when the potentials which reproduce the ANC are considered, but increases up to $\simeq 20$ % when all the five potential models are retained. The effect of this $S$-factor prediction on the $^6$Li primordial abundance is studied, using the public code PArthENoPE. For the five models considered here we find $^6{\rm Li}/$H$ = (0.9 - 1.8) \times 10^{-14}$, with the baryon density parameter in the 3-$��$ range of Planck 2015 analysis, $��_b h^2= 0.02226 \pm 0.00023$., 26 pages, 9 figures

The submerged Sill in the Messina Strait, which is located at a depth of -81 m m.s.l., represents the only possibile connection between Calabria and Sicily during the last lowstand, when the sea level was at about -126 m m.s.l. This multidisciplinary research aim at documenting times and modes the bridge between Calabria and Sicily was emerged, during the last 40 ka BP. The analysis carried out on morphobathymetric, lithological and relative sea level change (both isostatic and tectonic) data allow to hypothesize the continental bridge emerged at least between 21.5 ka and 20 ka cal BP. Moreover, considering erosion processes due to very strong marine currents, it could be emerged for a longer time span. This hypothesis is supported by anthropological and mammalofauna data, together with 14C dating on Equus hydruntinus from San Teodoro Cave. © 2012 Società Geologica Italiana, Roma.

We present a comprehensive review of keV-scale sterile neutrino Dark Matter, collecting views and insights from all disciplines involved - cosmology, astrophysics, nuclear, and particle physics - in each case viewed from both theoretical and experimental/observational perspectives. After reviewing the role of active neutrinos in particle physics, astrophysics, and cosmology, we focus on sterile neutrinos in the context of the Dark Matter puzzle. Here, we first review the physics motivation for sterile neutrino Dark Matter, based on challenges and tensions in purely cold Dark Matter scenarios. We then round out the discussion by critically summarizing all known constraints on sterile neutrino Dark Matter arising from astrophysical observations, laboratory experiments, and theoretical considerations. In this context, we provide a balanced discourse on the possibly positive signal from X-ray observations. Another focus of the paper concerns the construction of particle physics models, aiming to explain how sterile neutrinos of keV-scale masses could arise in concrete settings beyond the Standard Model of elementary particle physics. The paper ends with an extensive review of current and future astrophysical and laboratory searches, highlighting new ideas and their experimental challenges, as well as future perspectives for the discovery of sterile neutrinos.

The prolonged elevation of the intraocular pressure (IOP) is one of the main risk factor associated with Glaucoma. As a consequence, the current available pharmacological strategies for the treatment of this pathology (e. g. Prostaglandin F2alpha analogues, adrenergic beta blockers and carbonic anhydrase inhibitors) are essentially aimed to reduce IOP level. Unfortunately all these medical treatments are associated with relevant side effects or have significant percentage of non-responders, with the result that more than 50% of the patients failed to control the glaucoma progression. With the aim to develop novel lead compounds, without the important drawbacks of the existing drugs, we envisaged that the dual interaction with serotonin 2A (5-HT2A) and adrenergic alpha1 (α1) receptor could be a potential approach for ocular antihypertensive. This hypothesis is substantiate by the well-established effect of the two receptor systems on aqueous humour dynamic. In this work we briefly describe the discovery of the novel class of selective 5-HT2A receptor ligands (I) with balanced affinity for adrenergic α1 receptors. The general synthetic pathway used for the preparation of this class of compounds and the binding assay results of some representative products are showed. Moreover, we demonstrate the in vivo IOP reduction efficacy of one 3,4-dihydropyrazino[1,2-b]indazol-1(2H)-one derivative, by means of an ocular hypertensive rabbit model (carbomer model).

The OBS (acronym of Ocean Bottom Seismometer) is a system to monitor the submarine seismic activity. To properly work, an OBS system needs a suitable auto-levelling base to maintain a fixed (horizontal) position during the measurement phases. In this work a new auto-levelling base for submarine seismic sensors has been designed. During the redesign process a preliminary phase of analysis of the state of art has been made. Afterwards, the technological solutions chosen by different manufactures have been critically analysed, and a full description of their functionalities, working principles and system performances has been carried out. Later, some innovative concepts have been proposed. Among these ones, the most interesting are the auto-levelling bases with spherical joint, based on: air bearings, ball bearings and magnetic levitation systems. The concept scoring method has been used to identify. as best concept, the auto-levelling base with spherical joint and air bearings system. Successively, the chosen concept has been implemented: the technical working principles have been studied to choose the best solutions in terms of dimensions, shapes, materials of all base components. A full parametric CAD model of the auto-levelling base has been also created. The new designed base, by using a very innovative auto-levelling system, allows to obtain very good results as regards the accuracy of positioning, so ensuring a remarkable improvement of the performances of the ocean bottom seismometers.

A properly organized seismic network is a valuable tool formonitoring seismic zones and seismic risk assessment. This paper proposes a method for evaluating the performance in hypocenter location of a seismic network by numerical simulation (SNES, SeismicNetwork Evaluation through Simulation). The SNESmethod needs as input: the location of the stations that make the network and their noisiness, the velocity model used in the location routine and a law that allows to estimate the variance in the time residuals. This method gives, as function of magnitude, hypocentral depth and confidence level, the spatial distribution of: number of active stations in the location procedure and relative azimuthal gaps and confidence intervals in hypocentral parameters regarding both the geometry of the seismic network and the use of an inadequate velocity model. In recent years, the RSNC-INGV (Rete Sismica Nazionale Centralizzata dell’Istituto Nazionale di Geofisica e Vulcanologia, Italy) has been greatly increased. In fact, since 2009 it receive signals from 305 seismic stations with 258 wideband threecomponent sensors. Following the description of the SNES method and of the algorithms used, the results of its application to RSNC-INGV will be given. This application has allowed to indentify the noisiness of the RSNC-INGV and to evaluate the goodness of the velocity model used it the location routine. Furthermore, the SNES method has allowed to quantify the location performance of the RSNCINGV and to identify some seismogenic areas on the national territory that are currently not enough covered. The upgrading of the network in these areas could be optimized using the SNES technique.

The 3He(α,γ)7Be reaction presently represents the largest nuclear uncertainty in the predicted solar neutrino flux and has important implications on the big bang nucleosynthesis, i.e., the production of primordial 7Li. We present here the results of an experiment using the recoil separator ERNA (European Recoil separator for Nuclear Astrophysics) to detect directly the 7Be ejectiles. In addition, off-beam activation and coincidence γ-ray measurements were performed at selected energies. At energies above 1 MeV a large discrepancy compared to previous results is observed both in the absolute value and in the energy dependence of the cross section. Based on the available data and models, a robust estimate of the cross section at the astrophysical relevant energies is proposed.

A new method of searching for dark matter in the form of weakly interacting massive particles (WIMP) has been developed with the direct detection of the low energy nuclear recoils observed in a massive target (ultimately many tons) of ultra pure Liquid Argon at 87 K. A high selectivity for Argon recoils is achieved by the simultaneous observation of both the VUV scintillation luminescence and of the electron signal surviving columnar recombination, extracted through the liquid-gas boundary by an electric field. First physics results from this method are reported, based on a small 2.3 litre test chamber filled with natural Argon and an accumulated fiducial exposure of about 100 kg x day, supporting the future validity of this method with isotopically purified 40Ar and for a much larger unit presently under construction with correspondingly increased sensitivities., 26 pages, 8 figures, submitted to astroparticle physics

In third generation communication systems currently in standardization process, a number of multi-antenna schemes, derived from the well-known Bell Labs layered space-time (BLAST) approach, are being considered in order to improve performance in both communication reliability and system throughput. Among these schemes there is growing interest on schemes with feedback to aid the transmitter side (usually the Base Station) in adapting the transmission parameters, as modulation and coding rate and/or antenna/code power allocation, to the channel conditions. One of the proposed schemes is the Transmission Power Ratio Control (TPRC) for Multi-code Vertical-BLAST (with code domain serial interference cancellation, CD-SIC). The present work is motivated by observation that this scheme relies on negligibility of channel delay spread with respect to CDMA symbol length and ideal channel estimate both for data detection and feedback parameters estimation. Object of this paper is the qualitative and quantitative analysis of the effects of inter-symbol interference (ISI) and imperfect Channel State Information (CSI) on a receiving structure based on TPRC for CD-SIC. During the development of the present work, a generalized system model taking into account various channel impairments has been derived and reported.

This paper deals with the chronology and the possible correlations among levels of different excavated areas in the Pleistocene vertebrate-bearing deposits at the large San Teodoro Cave (North-Eastern Sicily). Two trenches have been excavated along the eastern side of the cave, located at a distance from the entrance, respectively, of 8m (a trench) and 28m (b trench) and at different depths. Lithological features, biometrical data from small mammals and ecological data from molluscs point to similar environmental conditions for the a trench deposits and those located along the eastern wall of the cave in the eastern part of the b trench. The same evidence, and the taphonomic features of large mammals, points to different environmental conditions and perhaps to different ages for the deposits located in the western part of the b trench. The survival of elephants in Sicily up to 32,000 years ago is a new significant result of the 230Th/234U dating carried out from a concretionary stratum from the b trench and represents the youngest elephant survival in the western Mediterranean islands.

IAHS-IAPSO-IASPEI Joint Assembly, Knowledge for the future, 22-26 July 2013, Gothenburg, Sweden, Within Europe, more than 380 Ocean Bottom Seismometers (OBS) are distributed across 10 instrument parks in 6 countries. At least 120 of these OBS are wideband or broadband, over 260 can be deployed for at least 6 months at a time and 140 for at least one year. New parks are planned in two other European countries, which should add over 70 OBSs to this “fleet”. However, these parks are under the control of individual countries or universities and hence to date this has made it difficult to organize large-scale experiments, especially for seismologists without marine experience. We report on a recent initiative to coordinate the use of these distributed instruments and their data products, to encourage large-scale experiments, possibly with onshore and offshore components, by seismologists who have not necessarily used OBSs before. The ongoing or planned developments include: Helping scientists with marine-specific formalities such as ship requests; clearer explanations of the noise floors of OBS instrumenta- tion; improved clarity of instrument pricing and availability; standardized data output formats and data validation; and archiving in established seismological data centers. These efforts should allow improved experiment design in scientifically interesting regions with an offshore component and an easier, clearer way to organize large-scale, multi-country experiments. We will present details of this initiative to help organize large-scale experiments, the particularities of OBS sensors and marine deployments, the available instrumentation and new developments