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64 results on '"Manganelli, R."'

1. Author Correction: Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo’ (Nature, (2020), 584, 7821, (425-429), 10.1038/s41586-020-2488-1)

Author

Lavezzo, E., Franchin, E., Ciavarella, C., Cuomo-Dannenburg, G., Barzon, L., Del Vecchio, C., Rossi, L., Manganelli, R., Loregian, A., Navarin, N., Abate, D., Sciro, M., Merigliano, S., De Canale, E., Vanuzzo, M. C., Besutti, V., Saluzzo, F., Onelia, F., Pacenti, M., Parisi, S. G., Carretta, G., Donato, D., Flor, L., Cocchio, S., Masi, G., Sperduti, A., Cattarino, L., Salvador, R., Nicoletti, M., Caldart, F., Castelli, G., Nieddu, E., Labella, B., Fava, L., Drigo, M., Gaythorpe, K. A. M., Ainslie, K. E. C., Baguelin, M., Bhatt, S., Boonyasiri, A., Boyd, O., Coupland, H. L., Cucunuba, Z., Djafaara, B. A., van Elsland, S. L., Fitzjohn, R., Flaxman, S., Green, W. D., Hallett, T., Hamlet, A., Haw, D., Imai, N., Jeffrey, B., Knock, E., Laydon, D. J., Mellan, T., Mishra, S., Nedjati-Gilani, G., Nouvellet, P., Okell, L. C., Parag, K. V., Riley, S., Thompson, H. A., Unwin, H. J. T., Verity, R., Vollmer, M. A. C., Walker, P. G. T., Walters, C. E., Wang, H., Wang, Y., Watson, O. J., Whittaker, C., Whittles, L. K., Xi, X., Brazzale, A. R., Toppo, S., Trevisan, M., Baldo, V., Donnelly, C. A., Ferguson, N. M., Dorigatti, I., and Crisanti, A.

Published
2021

2. Trend in rifampicin-, multidrug- and extensively drug-resistant tuberculosis in Italy, 2009-2016

Author

Mustazzolu, A., Borroni, E., Cirillo, D. M., Giannoni, F., Iacobino, A., Fattorini, L., Ghisetti, V., Mondo, A., Avolio, M., Barbui, A., Lorenzetti, P., De Renzi, G., Chirillo, M. G., Molinari, G., Camaggi, A., Andreoni, S., Piana, F., Marchese, A., Gritti, P., Icardi, G., Varnier, O., Mazzola, E., Gesu, G., Cichero, P., Lombardi, A., Libanori, E., Viggiani, P., De Lorenzo, S., Pinsi, G., Marone, P., Monzillo, V., Barbarini, D., Farina, C., Arosio, M., Peracchi, M., Manganelli, R., Fabris, C., Di Santolo, M., Busetti, M., Scarparo, C., Sartor, A., Pedrotti, C., Caola, I., Frizzera, E., Dal Monte, P., Pietrosemoli, P., Pecorari, M., Fabio, A., La Regina, A., Matteucci, M., Piersimoni, C., Bartolesi, A., Mannino, R., Simonetti, T., Tortoli, E., Rindi, L., Mencacci, A., Cenci, E., Luciano, E., Mazzolla, R., Sanguigni, I., Parisi, G., Chiaradonna, P., Altieri, A. M., D'Arezzo, S., Mazzarelli, A., Di Caro, A., Bordi, E., Sali, M., Delogu, G., Sanguinetti, M., Russo, C., Coltella, L., Ciocco, A., Meledandri, M., Gambi, A., Tomei, G., Conte, M., Santoro, G., Del Giudice, A., Nuzzolese, N., Vitullo, E., Sinno, A., Buono, L., Costa, D., Grimaldi, A., Di Taranto, A., De Nittis, R., Palumbo, G., Dodaro, S., Giraldi, C., Cavalcanti, P., Nistico, S., Vinci, L., Di Naso, C., Bonura, C., Maida, C. M., Mammina, C., Podda, G. S., Caddeu, R., Mustazzolu A., Borroni E., Cirillo D.M., Giannoni F., Iacobino A., Fattorini L., Ghisetti V., Mondo A., Avolio M., Barbui A., Lorenzetti P., De Renzi G., Chirillo M.G., Molinari G., Camaggi A., Andreoni S., Piana F., Marchese A., Gritti P., Icardi G., Varnier O., Mazzola E., Gesu G., Cichero P., Lombardi A., Libanori E., Viggiani P., De Lorenzo S., Pinsi G., Marone P., Monzillo V., Barbarini D., Farina C., Arosio M., Peracchi M., Manganelli R., Fabris C., Di Santolo M., Busetti M., Scarparo C., Sartor A., Pedrotti C., Caola I., Frizzera E., Dal Monte P., Pietrosemoli P., Pecorari M., Fabio A., La Regina A., Matteucci M., Piersimoni C., Bartolesi A., Mannino R., Simonetti T., Tortoli E., Rindi L., Mencacci A., Cenci E., Luciano E., Mazzolla R., Sanguigni I., Parisi G., Chiaradonna P., Altieri A.M., D'Arezzo S., Mazzarelli A., Di Caro A., Bordi E., Sali M., Delogu G., Sanguinetti M., Russo C., Coltella L., Ciocco A., Meledandri M., Gambi A., Tomei G., Conte M., Santoro G., Del Giudice A., Nuzzolese N., Vitullo E., Sinno A., Buono L., Costa D., Grimaldi A., Di Taranto A., De Nittis R., Palumbo G., Dodaro S., Giraldi C., Cavalcanti P., Nistico S., Vinci L., Di Naso C., Bonura C., Maida C.M., Mammina C., Podda G.S., and Caddeu R.

Subjects
0301 basic medicine, Pulmonary and Respiratory Medicine, Extensively Drug-Resistant Tuberculosis, Antitubercular Agents, Emigrants and Immigrants, Humans, Italy, Mycobacterium tuberculosis, Rifampin, Tuberculosis, Multidrug-Resistant, 03 medical and health sciences, 0302 clinical medicine, polycyclic compounds, medicine, Tuberculosis, biology, business.industry, Extensively drug-resistant tuberculosis, Multidrug-Resistant, medicine.disease, biology.organism_classification, Virology, 030104 developmental biology, 030228 respiratory system, business, Rifampicin, medicine.drug
Abstract

In Italy, rifampicin-resistant and MDR-TB were high in foreign-born persons, but decreased from 2009 to 2016

Published
2018

3. Mycobacterium tuberculosis CTP synthetase and pantothenate kinase: two promising targets for the development of multitargeting drugs

Author

Chiarelli, LR, Esposito, M, Orena, BS, Mori, G, Buttari, N, Degiacomi, G, Gosetti, F, Manfredi, M, Ekins, S, Mikušová, K, Bellinzoni, M, Manganelli, R, Marengo, E, Ballell-Pages, L, Riccardi, G, Pasca,MR, Chiarelli, L, Esposito, M, Orena, B, Mori, G, Buttari, N, Degiacomi, G, Gosetti, F, Manfredi, M, Ekins, S, Mikušová, K, Bellinzoni, M, Manganelli, R, Marengo, E, Ballell-Pages, L, Riccardi, G, and Pasca, M

Subjects
CHIM/01 - CHIMICA ANALITICA, Mycobacterium tuberculosis, pantothenate kinase, SWATH-MS
Published
2016

4. Tuberculosis in migrants from 106 countries to Italy, 2008-2014

Author

Lanfranco, Fattorini, Alessandro, Mustazzolu, Emanuele, Borroni, Giovanni, Piccaro, Federico, Giannoni, Daniela Maria Cirillo, the Italian Multicentre Study on Resistance to Antituberculosis drugs Group: Ghisetti, V, Mondo, A, Milano, R, Barbui, A, Lorenzetti, P, De Renzi, G, Chirillo, Mg, Molinari, G, Camaggi, A, Carità, Md, Gritti, P, Varnier, O, Senno, E, Mazzola, E, Gesu, G, Cichero, P, Lombardi, A, Libanori, E, De Lorenzo, S, Pinsi, G, Marone, P, Monzillo, V, Matteo, S, Farina, C, Arosio, M, Xxiii, G, Peracchi, M, Manganelli, R, Fabris, C, Scarparo, C, Pedrotti, C, Frizzera, E, Larcher, C, Monte, P, Lombardi, G, Fabio, A, Matteucci, M, Piersimoni, C, Simonetti, Mt, Tortoli, E, Rindi, Laura, Mazzolla, R, Luciano, E, Sanguigni, I, Chiaradonna, P, Tronci, M, Parisi, G, Natili, S, Bordi, E, De Mori, P, Sali, M, Delogu, G, Sanguinetti, M, Russo, C, Coltella, L, Meledandri, M, Ballardini, M, Tomei, G, Santoro, G, Conte, M, Nuzzolese, N, Colonna, C, Buono, L, Sinno, A, Vitullo, E, Costa, D, Grimaldi, A, Di Taranto, A, De Nittis, R, Dodaro, S, Cavalcanti, P, Giraldi, C, Nisticò, S, Di Naso, C, Caddeu, R., Lanfranco Fattorini, Alessandro Mustazzolu, Emanuele Borroni, Giovanni Piccaro, Federico Giannoni, Daniela Maria Cirillo, SMIRA laboratory network: [.., Dal Monte, P., Lombardi, G., and ]

Subjects
Pulmonary and Respiratory Medicine, Tuberculosis, Tuberculosi, Extensively Drug-Resistant Tuberculosis, Antitubercular Agents, Microbial Sensitivity Tests, Mycobacterium tuberculosi, World Health Organization, Russia, Mycobacterium tuberculosis, Antitubercular Agent, 03 medical and health sciences, 0302 clinical medicine, Environmental protection, Tuberculosis, Multidrug-Resistant, Humans, Medicine, 030212 general & internal medicine, Socioeconomics, Transients and Migrants, Geography, biology, Microbial Sensitivity Test, business.industry, Extensively drug-resistant tuberculosis, biology.organism_classification, medicine.disease, Europe, Italy, 030228 respiratory system, Multicenter study, Extensively Drug-Resistant Tuberculosi, Africa, business, Soviet union, Human
Abstract

In migrants coming to Italy from 106 countries, MDR-TB was high from the former Soviet Union and low from Africa http://ow.ly/WZDbo

Published
2016

6. Use of Quantiferon-TB in tube test in the diagnosis of non tuberculous mycobacteria lung disease

Author

Losi M, Fabio A, Dal Monte P, Peracchi M, Del Giovane P, Meacci M, Luppi F, Cerri S, Lombardi G, Fallico L, Apice MG, Spagnolo P, Rumpianesi F, Manganelli R, Fabbri LM, Richeldi L., Losi, M, Fabio, A, Dal Monte, P, Peracchi, M, Del Giovane, P, Meacci, M, Luppi, F, Cerri, S, Lombardi, G, Fallico, L, Apice, M, Spagnolo, P, Rumpianesi, F, Manganelli, R, Fabbri, L, and Richeldi, L

Subjects
Non tuberculous mycobacteria, Interferon-gamma based test
Published
2010

7. Effects of efficiency and length of acetate-free biofiltration session on post-dialysis solutes rebound

Author

GIANNATTASIO P, MINUTOLO, Roberto, BELLIZZI V, DI IORIO BR, SCIGLIANO R, ZAMBOLI, Pasquale, VENDITTI G, MANGANELLI R, DE SIMONE W, AUCELLA F, STALLONE C, SPIEZIA S, CONTE, Giuseppe, DE NICOLA, Luca, Giannattasio, P, Minutolo, Roberto, Bellizzi, V, DI IORIO, Br, Scigliano, R, Zamboli, Pasquale, Venditti, G, Manganelli, R, DE SIMONE, W, Aucella, F, Stallone, C, Spiezia, S, Conte, Giuseppe, and DE NICOLA, Luca

Published
2006

8. Effetto indipendente della durata della seduta dialitica in pazienti trattati con acetate-free biofiltration su rimozione intra-dialitica e 'rebound' post-dialitico dei principali soluti ritenuti nell’uremia

Author

GIANNATTASIO P, MINUTOLO, Roberto, SCIGLIANO R, BORRELLI S, BALDANZA D, TRUCILLO P, AVINO D, MANGANELLI R, DE SIMONE W, DI IORIO BR, BELLIZZI V, CONTE, Giuseppe, DE NICOLA, Luca, Sezione Campano-Siciliana della SIN, Giannattasio, P, Minutolo, Roberto, Scigliano, R, Borrelli, S, Baldanza, D, Trucillo, P, Avino, D, Manganelli, R, DE SIMONE, W, DI IORIO, Br, Bellizzi, V, Conte, Giuseppe, and DE NICOLA, Luca

Published
2003

10. Effetto indipendente della durata della seduta dialitica su rimozione intradialitica e rebound post-dialitico di potassio, fosforo, beta2microglobulina in pazienti trattati con acetate-biofiltration

Author

Giannattasio P, Bellizzi V, Manganelli R, Simeone P, Foglia B, Medugno M, Cioffi M, Di Iorio B, MINUTOLO, Roberto, CONTE, Giuseppe, De Simone W., DE NICOLA, Luca, Sezione Campana-Siciliana della SIN, Giannattasio, P, DE NICOLA, Luca, Bellizzi, V, Manganelli, R, Simeone, P, Foglia, B, Medugno, M, Cioffi, M, Di Iorio, B, Minutolo, Roberto, Conte, Giuseppe, and De Simone, W.

Published
2001

13. Recombinant Gram-positive bacteria as vehicles of vaccine antigens

Author

Medaglini D, Ricci S, Maggi T, Rush CM, Manganelli R, Oggioni MR, Pozzi G, Medaglini D, Ricci S, Maggi T, Rush CM, Manganelli R, Oggioni MR, and Pozzi G

Subjects
vaccine, food and beverages
Abstract

Gram-positive bacteria which are being developed as vaccine delivery systems include Lactococcus lactis, Lactobacillus spp., Streptococcus gordonii, nonpathogenic species of Staphylococcus, and Listeria. The use of these microorganisms relies on the fact that they are safe vehicles that can efficiently target vaccine antigens to the immune system. Two main approaches have been followed, according to the capacity of the bacterial vehicle to colonise the mucosal surfaces. Colonisers such as S. gordonii and some Lactobacilli can stimulate immune system by being transiently implanted among the normal flora of the host, while other lactobacilli, lactococci and staphylococci persist very shortly in the host and therefore their ability to generate an immune response must rely on high-level expression of the recombinant antigen. The immunogenicity of recombinant antigens by mucosal delivery has been demonstrated using colonising (S. gordonii) and noncolonising (Lc. lactis) bacterial vehicles. There is also great potential in the cellular responses induced by recombinant Listeria.

Published
1997

15. [Diagnostic pathway in a case with severe degree of hypertension]

Author

Manganelli R, Iannaccone S, Mario Iannaccone, De Simone E, Ferbo U, Nappi F, Avella F, and De Simone W

Subjects
Adult, Male, Glomerulosclerosis, Focal Segmental, Hypertension, Humans, Antiphospholipid Syndrome, Severity of Illness Index
Abstract

A 29- year-old male was admitted because of exertion dyspnea and intense headache. These symptoms were associated with severe hypertension, small multiple areas of cerebral ischemia, thrombocytopenia, prolonged aPTT and renal failure. The diagnostic tests performed during hospitalization resulted in a diagnosis of Primary Antiphospholipids Syndrome. The renal biopsy sample suggested histopathological features of uncommon simultaneous occurrence of antiphospholipids nephropathy and a "collapsing variant" of segmental focal glomerulosclerosis. It is fundamental to be aware that this syndrome is very likely to occur, and therefore to perform antiphospholipids antibodies assessment, since only an anticoagulant therapy proves effective; nevertheless, in view of the pathological renal findings, other therapies such as steroids might be added.

Published
2006

25. PEGylation of the antimicrobial peptide nisin A: problems and perspectives

Author

Guiotto A., Pozzobon M., Canevari M., Manganelli R., Scarin M, and Veronese F.M.

Subjects
food and beverages
Abstract

Nisin is a natural antimicrobial peptide produced by Lactococcus lactis and widely employed as food preservative. Its low solubility in neutral aqueous solutions, its instability at physiological pH and its rapid breakdown by proteolytic enzymes has limited its use for processed foods (processed cheese, milk and derivatives, canned vegetables). The conjugation to poly(ethylene glycol) (PEG) could improve its solubility and protect it towards enzymes present in non optimally processed food. We report the synthesis of a PEG-nisin conjugate, and the microbiology assays against some bacterial cell lines.

Published
2003

28. A Tn916-like element integrated into the conjugative transposon Tn5253

Author

Manganelli R, Oggioni MR, Pozzi G, Manganelli R, Oggioni MR, and Pozzi G

Subjects
Tn5253, Streptococcus gordonii, biochemical phenomena, metabolism, and nutrition
Abstract

Tn5253 (formerly _O_(cat-teL)6001) is a conjugative transposon originally found into the chromosome of Streptococcus pneumoniae (6). It is 65.5 kb in size, and carries a cat and a tetM gene (7,8). Tn5253 can be transferred by conjugation to the chromosomes of different streptococcal species: S. pneumoniae, Streptococcus gordonii ( Streptococcus sanguis), Streptococcus pyogenes, Streptococcus agalactiae, and Enterococcus faecal is ( 3, 6). Both genes for drug resistance appeared to be within Lwo separate genetic elements integrated into Tn5253. The cat element was 7.7 kb in size and was flanked by direct repeats ( S. Priebe, unpublished results), whereas the tet element was highly homologous to the 16.4-kb streptococcal conjugative transposon Tn916 (2). Restriction mapping and Southern blot analysis showed that all 5 internal HincII fragments of Tn916 (5) were also p:;:-e::;ent in Tn5253 (Figure 1), and that their size and relative position were similar in the two conjugative transposons. DNA sequence homology was also detected between corresponding HincII fragments. It appeared as if one copy of Tn916, carrying thEi tetM gene was integrated into Tn5253.

Published
1992

29. Expression of M6 protein of Streptococcus pyogenes on the surface of Streptococcus gordonii Challis

Author

Oggioni MR, Manganelli R, Plevani P, Fischetti VA, Pozzi G, Oggioni MR, Manganelli R, Plevani P, Fischetti VA, and Pozzi G

Subjects
stomatognathic diseases, stomatognathic system, transposon, vaccine
Abstract

The M6 protein of Streptococcus pyogenes was expressed on the cell surface and secreted in Streptococcus gordonii Challis (formerly Streptococcus sanguis) after chromosomal integration of a promoterless M6 protein gene (emm-6.1). The ermC gene, conferring resistance to erythromycin, was cloned downstream of emm-6.1, within the same ClaI fragment. The initiation codon of emm-6.1 was 19 bp downstream of a ClaI site, so that ClaI cleavage would leave the gene promoterless. The ClaI fragment containing the promoterless emm-6.1 and ermC was ligated in vitro with a ClaI digest of S. gordonii chromosomal DNA. Random chromosomal integration of the heterologous DNA was obtained by using the ligation mixture to transform the naturally competent S. gordonii Challis. Twenty-eight percent of transformants selected for erythromycin resistance also expressed M6. Among the best M6 producers, 10 clones were selected for the stability of their phenotype. Nine of the 10 clones were shown to harbour one intact copy of the emm-6.1/ermC ClaI fragment integrated into the chromosome. These strains both expressed M6 protein on the surface and secreted different amounts of the molecule, since in each case the protein was produced after a transcriptional fusion of emm-6.1 with a different chromosomal promoter. A S. gordonii strain expressing large amounts of surface M6 protein, as judged by immunofluorescence and Western blot, was compared to the M- parental strain in a standard opsonophagocytosis assay. Of the isogenic pair, M6+ S. gordonii survived better in human blood and was phagocytosed at a slower rate.

Published
1992

44. Recombinant Gram-positive bacteria as vehicles of vaccine antigens

Author

Medaglini, Donata, Ricci, Susanna, Maggi, T., Rush, C. M., Manganelli, R., Oggioni, M. R., and Pozzi, Gianni

Subjects
vaccine vectors, mucosal vaccine delivery, Gram-positive bacteria, Gram-positive bacteria, mucosal vaccine delivery, vaccine vectors
Published
1997

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