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4 results on '"Maharshi Panchal"'

2. A functional genomics screen identifying blood cell development genes in Drosophila by undergraduates participating in a course-based research experience

Author

Ryan Chan, Joshua P Hedtke, Michael T Chang, Kristen M Omi, Namrata Kakade, William Y. Luo, Yurianna Hou, Gloria Chin Young, Sunjong Ji, Mai Abdusamad, Amy Ngo, Maggie M Yung, Carissa Chan, Sharon Lee, Mark R Murata, Ashwin Shinde, Jason P Xu, Angelica C Ayala, Emily Jin Kyung Kim, Elitzander Alegria‐Leal, Phuong Vo, Yuan Wan, Vivian K Chen, Raghav Goyal, Anabel Resendiz, Harin B Parikh, Jaime S Tan, Leah C Dorman, Annisa N Soeboer, Seethim Naicker, Pratyush Kandimalla, Petros S Dertsakyan, Faith A Hobby, Beatrice J Sun, Karen Hoi, Megha Pokhriyal, C Kimberly Tsui, Nguyen Khoi Le, Umar Chaudhary, Patrick Chin, Woo Kyeom Kim, Mengshi He, David A Sanville, Utpal Banerjee, Christine Sutanto, Tiffany Luu, Joshua Lin, Tony Yao, Josephine Liu, Janani Muthaiya, Ravinder Kaur, Steven V. Pham, Andrea Vega-Loza, Mia Lim, Nataliya S Balashova, Adam T Quaal, Hnin Hlaing, Patrick A. Truong, Bryan Stender, Harmanjit Bassi, Erwin Feng, Yuxuan Wang, Sarah Salarkia, Rina H Nguyen, Gloria Lam, Garuem Sin, Seong Ah Kim, Sindhuja Godavarthi, Jialing Li, Eileen Hu, Cindy La, Elaine Sang, Jun Ho Chung, Jinhua Shen, Celesti Hao, Josh Mytych, Elliott Wu, Jin Hee Kim, Duy Tran, Neel Chari, Andie O'Laughlin, Christopher J Smith, Mona Abutouk, Chak Lon Kuang, Pei-Hua Tsai, Alisa Sukhina, Li Li, Chongbin He, Daniel Wong, Jahzeel Paguntalan, Emily R Schoen, Edgar Corona, Vivian Yip, Trisha H Patel, Emily Kim, Ira E. Clark, Andrew Char, Guadalupe Ortega Almazan, Asmar Abdul Ghani, Nadiyah Priasti, Duy Q Ngo, Gabrielle Sibal, Sean P Bennion, Stephanie Pang, Vivien W. Ho, Rachel S Distler, Nateli Sama, Josef Madrigal, Maharshi Panchal, Zijie Cai, Ashley C. Hope, Miriam Beyder, Daphne Jin, Steven C Liu, John M. Olson, Janice Ly, Eric Wang, Irene Louie, Wilson Huang, Justin Rafael de la Fuente, Nathan Stutzman, Bilguudei Naranbaatar, Rose Graf, Jonelle Mungcal, Jason Capili, Ziqi Zhou, Kelly M Gu, Julie Ko, Jeffrey A Kho, Amber J Li, Daniel Tran, Cory J. Evans, Jocelyn Woo, Kristen Schnell, Praptee Chowdhury, Chi Ju Lee, Grace J. Lee, Tracy L. Johnson, Nadezhda Riabkova, David Lopatto, Amanda Phan, Mary C Onglatco, Stephanie Huang, Zhiqiao Dong, Sat Kartar Khalsa, Saurin Kadakia, Maique Vo, Jessica Ye, Eric Lin, Darron Miya, Julia A. Ainsworth, Nicholas James, Jonathan Chang, Chloe C Su, Jeffrey Lin, Leslie Jaworski, Jenna Kovsky, Alice Hsu, Michel Chen, Allysen B Ehresman, Ju-Yeon Lee, Talin Golnazarian, Dana Lee, Kai Y Alexander, Jill Zimmerman, Lauren Johnson, Bosco Q Giap, Jamlah Dalie, Jackson K Uriu, Amala John, Osvaldo Acosta, Tebogo Mokwena, Sanan Venkatesh, Brandon L. Tsai, Haris M Akram, Seo-Kyung Oh, Andrea T Fua, Mark A Douglass, Rebecca Yang, Jessica M. Lee, Derek Spitters, Carmen Javier, Alex W Chan, Richard Wong, Ivy H Fu, Connie Y Liu, Parich Tangmatitam, Sena Ji, Claire Park, Arash Ghaffari-Rafi, Vincent T Nguyen, Dorothy Yim, Kush V. Bhatt, Tonatiuh Montoya, Rayna Tian, Vivian Chiu, Malcolm Phung, Victoria Lee, Chinmay Bhoot, Purvi D Patel, Jensen Pak, Puja Yogi, Zhouyang Shen, Nhat-Thi Vo, Bama Charan Mondal, Davis W Popovich, Mane Williams, Oscar M A Del Rio, Alexander J Chassiakos, Ruth Ryu, Zijun Zhao, Renae L Cruz, Yishan Mai, Michael K Wang, Kenneth Chang Chien, Kayla Patel, Jun Wang, Courtney J Cruz, Nicholas J Gills, Alexis Baranoff, Dinali Wijiewarnasurya, Yancey Y Cashell, Iman Hamid, Ashley Hanson, Olivia L Lee, Jasmine Sjarif, Patrick W Chang, Jasmin Johal, Monica Ghaly, Momoko Ishii, Alexandra M Libro, Boyu Cao, Paras Shah, Jennifer Hsueh, Aaron W Bradshaw, Jagteshwar Singh Khatra, Tien M Phan-Everson, Jonathan Lai, David J. Lim, Na Eun Jeon, Caleb Kim, Hyun Wook Kim, Hannah Kim, Sean Full, Tierney G Brannigan, Inho Chang, Suhas P Dasari, Emily R Dennis, Ceejay Lee, Alexander Zai, Christine Zhang, Ayse Elif Kesaf, Ralph Albert, Rebecca M Barber, Shijia W Lu, Austin Ma, Spencer S Hu, Ipsita Dey, Hee Jong Kim, Nancy Ruano, Timothy C Voros, Sarah M. Kamel, Kimberly L Yan, Gah-Eun Jang, Dallas L Mould, Eduardo Hernandez, Sahra M Hosseinian, Iris Chen, Chon Ao, Cindy K Trac, Eric Y Du, Sam Law, Ysrael K Hernandez, Jeffrey S. Zhao, Angad Beniwal, Patricia Yeo, Vina Tran, James R. Lee, Manny Sosa, Zheying Chen, Alec Estrada, Cristian Sosa, Kevin Herrera, Mina Mohammadi, Rina Watanabe, Timothy Chai, Huy Nguyen, Dong Yeon Lee, Vishaal Yepuri, Melanie Huynh, Kyle Marik, Thao T T Nguyen, Xiao X Zhang, Jamie A Ngo, Anh Nguyen, Colton Bracken, Brandon Wei, Brian Aguirre, Sayonika Mohanta, Jeffrey C. Wang, Casey Shapiro, Sonia Gill, Fred Rong, Lauren Petersen, Pingdi Huang, Alexander Grunfeld, Sang Kuk Lee, An N Ha, Kevin Nishida, Shraddha Kumar, Terrence C Lee, Ariano Abbasi, Jenny Summapund, Karl Querubin, Siman Wei, Hanning Xing, Evan Yang, Liset Contreras, Sahar Yaftaly, Matthew Wilson, Ken Siangchin, Brian Kit, Mallory R Neebe, Irvin C Lien, Julia E Petersen, Jonathan Woo, Kaitlyn Honeychurch, Jesse Juarez, Stephen Chang, Raymond Zhou, Cristian Medina, Sean Louise G Laput, Jason T. Lee, Nguon L Tan, Sharon Choi, Natalia C Gutierrez, Zafar S Gill, Kenneth Kim, Jefferson M Dang, Tanveer Salim, Marc Levis-Fitzgerald, Dan Huynh, Joyce Wang, Marsha R Cheng, Lillian Xie, Hannah Markovic, Conny Tran, Mimi Chiang, Vivian Lam, Nick Waite, Ricardo Gray, and Jo M Huang

Subjects
AcademicSubjects/SCI01140, Candidate gene, Cell type, Universities, AcademicSubjects/SCI00010, Computational biology, Biology, AcademicSubjects/SCI01180, 03 medical and health sciences, 0302 clinical medicine, blood, RNA interference, Genetics, Animals, Humans, Students, Molecular Biology, Gene, Genetics (clinical), Loss function, CURE, 030304 developmental biology, Investigation, education, 0303 health sciences, Blood Cells, Genomics, hematopoiesis, Undergraduate research, RNAi, AcademicSubjects/SCI00960, Drosophila, Functional genomics, 030217 neurology & neurosurgery, Function (biology)
Abstract

Undergraduate students participating in the UCLA Undergraduate Research Consortium for Functional Genomics (URCFG) have conducted a two-phased screen using RNA interference (RNAi) in combination with fluorescent reporter proteins to identify genes important for hematopoiesis in Drosophila. This screen disrupted the function of approximately 3500 genes and identified 137 candidate genes for which loss of function leads to observable changes in the hematopoietic development. Targeting RNAi to maturing, progenitor, and regulatory cell types identified key subsets that either limit or promote blood cell maturation. Bioinformatic analysis reveals gene enrichment in several previously uncharacterized areas, including RNA processing and export and vesicular trafficking. Lastly, the participation of students in this course-based undergraduate research experience (CURE) correlated with increased learning gains across several areas, as well as increased STEM retention, indicating that authentic, student-driven research in the form of a CURE represents an impactful and enriching pedagogical approach.

Published
2021
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3. Cyclooxygenase inhibition targets neurons to prevent early behavioural decline in Alzheimer's disease model mice

Author

Ginger L. Milne, Taline V. Khroyan, Marieke van der Hart, Katrin I. Andreasson, H. Craig Heller, Prachi Priyam, Amy B. Manning-Boğ, Damien Colas, Bayarsaikhan Chuluun, Irene Zagol-Ikapitte, Qian Wang, Nathaniel S. Woodling, Paras S. Minhas, Xibin Liang, Maharshi Panchal, Siddhita D. Mhatre, Novie Ko, Arash Rassoulpour, Olivier Boutaud, and Holden D. Brown

Subjects
0301 basic medicine, Male, Modern medicine, Kynurenine pathway, Hippocampus, Down-Regulation, Gene Expression, Ibuprofen, Pharmacology, 03 medical and health sciences, Mice, 0302 clinical medicine, Dopamine, Alzheimer Disease, medicine, Animals, Cyclooxygenase Inhibitors, Cognitive decline, Neurons, Memory Disorders, Neuronal Plasticity, biology, Behavior, Animal, organic chemicals, Electroencephalography, Recognition, Psychology, Original Articles, medicine.disease, Tryptophan Oxygenase, Rats, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, Synaptic plasticity, biology.protein, Neurology (clinical), Cyclooxygenase, Alzheimer's disease, Psychology, Neuroscience, 030217 neurology & neurosurgery, medicine.drug, Signal Transduction
Abstract

Identifying preventive targets for Alzheimer's disease is a central challenge of modern medicine. Non-steroidal anti-inflammatory drugs, which inhibit the cyclooxygenase enzymes COX-1 and COX-2, reduce the risk of developing Alzheimer's disease in normal ageing populations. This preventive effect coincides with an extended preclinical phase that spans years to decades before onset of cognitive decline. In the brain, COX-2 is induced in neurons in response to excitatory synaptic activity and in glial cells in response to inflammation. To identify mechanisms underlying prevention of cognitive decline by anti-inflammatory drugs, we first identified an early object memory deficit in APPSwe-PS1ΔE9 mice that preceded previously identified spatial memory deficits in this model. We modelled prevention of this memory deficit with ibuprofen, and found that ibuprofen prevented memory impairment without producing any measurable changes in amyloid-β accumulation or glial inflammation. Instead, ibuprofen modulated hippocampal gene expression in pathways involved in neuronal plasticity and increased levels of norepinephrine and dopamine. The gene most highly downregulated by ibuprofen was neuronal tryptophan 2,3-dioxygenase (Tdo2), which encodes an enzyme that metabolizes tryptophan to kynurenine. TDO2 expression was increased by neuronal COX-2 activity, and overexpression of hippocampal TDO2 produced behavioural deficits. Moreover, pharmacological TDO2 inhibition prevented behavioural deficits in APPSwe-PS1ΔE9 mice. Taken together, these data demonstrate broad effects of cyclooxygenase inhibition on multiple neuronal pathways that counteract the neurotoxic effects of early accumulating amyloid-β oligomers.

Published
2015

4. Prostaglandin signaling suppresses beneficial microglial function in Alzheimer’s disease models

Author

Qian Wang, Katrin I. Andreasson, Xibin Liang, Siddhita D. Mhatre, Holden D. Brown, Jenny U. Johansson, Nathaniel S. Woodling, Maharshi Panchal, Angel Trueba-Saiz, and Taylor M. Loui

Subjects
Male, Chemokine, Prostaglandin E2 receptor, Presynaptic Terminals, Gene Expression, Inflammation, Mice, Transgenic, Plaque, Amyloid, Biology, Hippocampus, Dinoprostone, 03 medical and health sciences, 0302 clinical medicine, Immune system, Alzheimer Disease, medicine, Animals, Cells, Cultured, 030304 developmental biology, Spatial Memory, 0303 health sciences, Innate immune system, Amyloid beta-Peptides, Microglia, Chemotaxis, General Medicine, Receptors, Prostaglandin E, EP2 Subtype, medicine.disease, Peptide Fragments, Mice, Inbred C57BL, medicine.anatomical_structure, Immunology, biology.protein, Female, medicine.symptom, Alzheimer's disease, Signal transduction, Chemokines, Transcriptome, Neuroscience, 030217 neurology & neurosurgery, Research Article, Signal Transduction
Abstract

Microglia, the innate immune cells of the CNS, perform critical inflammatory and noninflammatory functions that maintain normal neural function. For example, microglia clear misfolded proteins, elaborate trophic factors, and regulate and terminate toxic inflammation. In Alzheimer's disease (AD), however, beneficial microglial functions become impaired, accelerating synaptic and neuronal loss. Better understanding of the molecular mechanisms that contribute to microglial dysfunction is an important objective for identifying potential strategies to delay progression to AD. The inflammatory cyclooxygenase/prostaglandin E2 (COX/PGE2) pathway has been implicated in preclinical AD development, both in human epidemiology studies and in transgenic rodent models of AD. Here, we evaluated murine models that recapitulate microglial responses to Aβ peptides and determined that microglia-specific deletion of the gene encoding the PGE2 receptor EP2 restores microglial chemotaxis and Aβ clearance, suppresses toxic inflammation, increases cytoprotective insulin-like growth factor 1 (IGF1) signaling, and prevents synaptic injury and memory deficits. Our findings indicate that EP2 signaling suppresses beneficial microglia functions that falter during AD development and suggest that inhibition of the COX/PGE2/EP2 immune pathway has potential as a strategy to restore healthy microglial function and prevent progression to AD.

Published
2014

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